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DTSTART;TZID=Europe/Madrid:20261102T113000
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DTSTAMP:20260925T073511Z
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SUMMARY:Ibec Seminar. Hironobu Fujiwara
DESCRIPTION:Multiscale dynamics and mechanics of the basement membrane in epithelial morphogenesis\nHironobu Fujiwara\, RIKEN Center for Biosystems Dynamics Research (BDR)\, Kobe\, Japan \nThe basement membrane (BM) is a highly organized extracellular matrix that underlies or surrounds most tissues\, providing mechanical and biochemical cues. How the BM dynamically remodels during tissue morphogenesis remains poorly understood. By developing fluorescent ECM reporter mouse models and applying quantitative 4D imaging to developing skin\, we investigate how BM molecular turnover\, tissue mechanics\, and epithelial growth are coordinated during hair follicle morphogenesis. Our recent work reveals spatially patterned BM remodeling\, in which local incorporation and removal of matrix molecules are coupled to tissue deformation and mechanical forces. By combining live imaging\, perturbation experiments\, and computational modelling\, we are beginning to uncover how molecular turnover enables the BM network to expand\, reorganize\, and adapt its mechanical state as tissues change shape. These studies suggest that the BM functions as a dynamic material rather than a static scaffold\, providing principles that may ultimately inform the design of adaptive extracellular matrices. \n  \nHironobu Fujiwara received his PhD in extracellular matrix biology from Osaka University and completed postdoctoral training with Dr. Kiyotoshi Sekiguchi. In 2007\, he joined Dr. Fiona Watt’s laboratory in Cambridge\, where he discovered that the basement membrane surrounding hair follicle stem cells functions as a specialized muscle cell niche. In 2012\, he established his laboratory at the RIKEN Center for Developmental Biology (CDB)\, now the RIKEN Center for Biosystems Dynamics Research (BDR). His research focuses on how extracellular matrix (ECM) dynamics regulate tissue morphogenesis and regeneration. His group develops fluorescent ECM reporter mouse models and quantitative 4D imaging approaches to visualise cell–ECM interactions in living mammalian tissues. By integrating multiscale imaging\, transcriptomics\, biophysics\, and modelling\, his laboratory aims to uncover principles of morphogenesis and explore how multicellular systems can be controlled through matrix design. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-hironobu-fujiwara/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20261120T120000
DTEND;TZID=Europe/Madrid:20261120T130000
DTSTAMP:20260922T104004Z
CREATED:20260922T104004Z
LAST-MODIFIED:20260922T104004Z
UID:136182-1795176000-1795179600@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Sara Mederos
DESCRIPTION:Brainwide circuits for adaptive decisions in response to threat\nSara Mederos\, neuroscientist and Ramón y Cajal group leader of NeuCompLab at the Hospital del Mar Research Institute  \nTo understand adaptive behavior\, we must understand how decisions are computed and updated through experience. For example\, when facing a potential threat\, animals may initially rely on  instinctive responses\, such as escape\, yet with experience they can suppress these reactions as the environment is reinterpreted. In this talk\, I will show how these transformations arise from  interactions between cortical and subcortical circuits that dynamically reshape decision  variables in aversive contexts. \nUsing an ethologically grounded paradigm in which mice escape from an overhead looming  stimulus that mimics an aerial predator\, I will show that repeated exposure leads to suppression of this instinctive response. We find that higher visual areas instruct this learning through projections to the inhibitory ventrolateral geniculate nucleus (vLGN). Neural population recordings reveal that specific vLGN neurons increase their activity across learning and are necessary for the expression of escape suppression\, indicating that cortical inputs instruct learning\, while plasticity within vLGN implements the learned behavioral change. \nI will then extend this framework to show how vLGN integrates inputs from retrosplenial cortex and hypothalamic circuits to regulate decisions between safety and exploration. These pathways carry distinct signals related to prior experience and internal state\, and their coordinated activity shapes when animals decide to leave safety. ogether\, these results reveal circuit mechanisms through which experience reshapes decision-making in aversive environments.\nFinally\, I will present ongoing work showing how acute stress induces persistent changes in hippocampal dynamics\, linking experience-dependent updating of threat with longer-lasting circuit adaptations that may be relevant for anxiety and PTSD. \n\nSara Mederos is a neuroscientist and Ramón y Cajal group leader of NeuCompLab at the Hospital del Mar Research Institute in Barcelona (neucomplab.com). She trained in \nBiochemistry and Neuroscience and completed her PhD in Perea’s lab at the Instituto Cajal (CSIC)\, where she studied communication between neurons and astrocytes\, contributing to \ndemonstrate that these cells actively participate in synaptic plasticity\, learning\, and goaldirected behaviour (Glia\, 2019; Nature Neuroscience\, 2021). During this period she also developed short research stays at the Buzsáki Lab (NYU) and the Ponomarenko Lab (HHU Düsseldorf). She subsequently developed her postdoctoral research in Hofer’s lab at the \nSainsbury Wellcome Centre\, University College London\, and later as an independent PI supported by a Wellcome Trust Early Career Award\, where she dissected the neuronal circuits and mechanisms underlying how experience and learning can modify instinctive responses such as fear (Science\, 2025). Her laboratory studies how the brain integrates information about the environment\, prior experience\, and internal states to make flexible decisions. Her research integrates advanced neuroscience techniques\, including in vivo electrophysiology in freely moving mice\, optogenetics\, in vitro electrophysiology\, and serial-section two-photon imaging\, to dissect the neural circuits underlying flexible decision-making. This work has provided new insights into how cortical and subcortical circuits interact to support learned safety and adaptive behaviour. Her research is supported by competitive international funding from the European Research Council\, the Wellcome Trust\, the AEI\, the BBRF\, and the BBVA Foundation. Among other recognitions\, she has received the FENS EJN Young Investigator Prize\, the Janett Rosenberg Trubatch Career Development Award\, and the L’Oréal-UNESCO For Women in Science Spain Award\, and was selected as a finalist for the Eppendorf & Science Prize for Neurobiology
URL:https://ibecbarcelona.eu/event/ibec-seminar-sara-mederos/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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