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TZID:Europe/Madrid
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DTSTART:20160327T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170606T150000
DTEND;TZID=Europe/Madrid:20170607T170000
DTSTAMP:20260404T003619
CREATED:20161223T091140Z
LAST-MODIFIED:20161223T091140Z
UID:95973-1496761200-1496854800@ibecbarcelona.eu
SUMMARY:IBEC's 10th Anniversary Symposium
DESCRIPTION:Bioengineering for future medicine\nThis year’s symposium is extra special\, as it marks ten years of research results since IBEC’s inception at the end of 2006. \nThroughout 2017 we’ll be celebrating our first decade of activity with various events\, among them this year’s symposium on Bioengineering for Future Medicine. \nThe IBEC annual symposium brings together high-profile international experts for an open forum for interdisciplinary discussions and networking. The whole scientific community is invited to participate. \nResearchers are welcome to present their projects in a poster format for the 10th Symposium. Some of these contributions will be selected\, by the scientific committee\, for an oral flash presentation. \nVisit the symposium website for more details and to register. \nImportant deadlines:\nAbstract submission Alumni: 23rd April 2017 (notification of acceptance: 28th April)\n Abstract submission IBEC members: 1st May 2017 (notification of acceptance: 19th May)\n Registration deadline: 24th May 2017
URL:https://ibecbarcelona.eu/event/10th-ibec-birthday-symposium-4/
LOCATION:AXA Auditorium\, L'illa Diagonal\, Av. Diagonal 547 \, Barcelona\, 08029
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170602T100000
DTEND;TZID=Europe/Madrid:20170602T110000
DTSTAMP:20260404T003619
CREATED:20170529T132500Z
LAST-MODIFIED:20170529T132500Z
UID:96069-1496397600-1496401200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Esteve Trias & Oscar Fariñas\, BTB
DESCRIPTION:Research challenges of the Barcelona Tissue Bank\n Esteve Trias\, Oscar Fariñas – Barcelona Tissue Bank (Banc de Sang I Teixits)\nThe Barcelona Tissue Bank (BTB) is a multi-tissue bank which belongs to the Banc de Sang i Teixits (BST)\, a public company of the Department of Health of the Generalitat de Catalunya\, whose mission is to ensure the supply and proper use of blood and Tissue in Catalonia.\nThe BTB controls the entire process of donation and transplantation globally\, from the process of detection and evaluation of the potential donor\, obtention or extraction\, processing of the different tissues\, storage and distribution until transplantation.\nIn the BTB we can distinguish five major banks: ocular\, cardiovascular\, skin\, musculoskeletal and reproductive.\nMusculoskeletal tissue bank represents 50% of the activity of BTB\, covering approximately 85% of transplanted tissue in the Spanish state. Different types of tissues are processed through a decontamination process to ensure maximum security. The purpose of the great variety of processed tissues is to meet the different needs of surgeons\, being the most common ligament reconstruction\, filling bone defects\, tumour surgery and meniscal transplantation.\nResearch\, development and innovation of new products and processes are constant priorities to provide the best solution for patients by setting up different lines of R & D in the short\, medium and long term.
URL:https://ibecbarcelona.eu/event/seminario-de-id-del-banc-de-sang-i-teixits-bst-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170602T100000
DTEND;TZID=Europe/Madrid:20170602T110000
DTSTAMP:20260404T003619
CREATED:20170529T132500Z
LAST-MODIFIED:20170529T132500Z
UID:96070-1496397600-1496401200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Esteve Trias & Oscar Fariñas\, BTB
DESCRIPTION:Research challenges of the Barcelona Tissue Bank\n Esteve Trias\, Oscar Fariñas – Barcelona Tissue Bank (Banc de Sang I Teixits)\nThe Barcelona Tissue Bank (BTB) is a multi-tissue bank which belongs to the Banc de Sang i Teixits (BST)\, a public company of the Department of Health of the Generalitat de Catalunya\, whose mission is to ensure the supply and proper use of blood and Tissue in Catalonia.\nThe BTB controls the entire process of donation and transplantation globally\, from the process of detection and evaluation of the potential donor\, obtention or extraction\, processing of the different tissues\, storage and distribution until transplantation.\nIn the BTB we can distinguish five major banks: ocular\, cardiovascular\, skin\, musculoskeletal and reproductive.\nMusculoskeletal tissue bank represents 50% of the activity of BTB\, covering approximately 85% of transplanted tissue in the Spanish state. Different types of tissues are processed through a decontamination process to ensure maximum security. The purpose of the great variety of processed tissues is to meet the different needs of surgeons\, being the most common ligament reconstruction\, filling bone defects\, tumour surgery and meniscal transplantation.\nResearch\, development and innovation of new products and processes are constant priorities to provide the best solution for patients by setting up different lines of R & D in the short\, medium and long term.
URL:https://ibecbarcelona.eu/event/seminario-de-id-del-banc-de-sang-i-teixits-bst-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170602T100000
DTEND;TZID=Europe/Madrid:20170602T110000
DTSTAMP:20260404T003619
CREATED:20170529T132500Z
LAST-MODIFIED:20170530T125041Z
UID:29677-1496397600-1496401200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Esteve Trias & Oscar Fariñas\, BTB
DESCRIPTION:Research challenges of the Barcelona Tissue Bank\n Esteve Trias\, Oscar Fariñas – Barcelona Tissue Bank (Banc de Sang I Teixits)\nThe Barcelona Tissue Bank (BTB) is a multi-tissue bank which belongs to the Banc de Sang i Teixits (BST)\, a public company of the Department of Health of the Generalitat de Catalunya\, whose mission is to ensure the supply and proper use of blood and Tissue in Catalonia.\nThe BTB controls the entire process of donation and transplantation globally\, from the process of detection and evaluation of the potential donor\, obtention or extraction\, processing of the different tissues\, storage and distribution until transplantation.\nIn the BTB we can distinguish five major banks: ocular\, cardiovascular\, skin\, musculoskeletal and reproductive.\nMusculoskeletal tissue bank represents 50% of the activity of BTB\, covering approximately 85% of transplanted tissue in the Spanish state. Different types of tissues are processed through a decontamination process to ensure maximum security. The purpose of the great variety of processed tissues is to meet the different needs of surgeons\, being the most common ligament reconstruction\, filling bone defects\, tumour surgery and meniscal transplantation.\nResearch\, development and innovation of new products and processes are constant priorities to provide the best solution for patients by setting up different lines of R & D in the short\, medium and long term.
URL:https://ibecbarcelona.eu/event/seminario-de-id-del-banc-de-sang-i-teixits-bst/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170602T100000
DTEND;TZID=Europe/Madrid:20170602T110000
DTSTAMP:20260404T003619
CREATED:20170529T132500Z
LAST-MODIFIED:20170529T132500Z
UID:96068-1496397600-1496401200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Esteve Trias & Oscar Fariñas\, BTB
DESCRIPTION:Research challenges of the Barcelona Tissue Bank\n Esteve Trias\, Oscar Fariñas – Barcelona Tissue Bank (Banc de Sang I Teixits)\nThe Barcelona Tissue Bank (BTB) is a multi-tissue bank which belongs to the Banc de Sang i Teixits (BST)\, a public company of the Department of Health of the Generalitat de Catalunya\, whose mission is to ensure the supply and proper use of blood and Tissue in Catalonia.\nThe BTB controls the entire process of donation and transplantation globally\, from the process of detection and evaluation of the potential donor\, obtention or extraction\, processing of the different tissues\, storage and distribution until transplantation.\nIn the BTB we can distinguish five major banks: ocular\, cardiovascular\, skin\, musculoskeletal and reproductive.\nMusculoskeletal tissue bank represents 50% of the activity of BTB\, covering approximately 85% of transplanted tissue in the Spanish state. Different types of tissues are processed through a decontamination process to ensure maximum security. The purpose of the great variety of processed tissues is to meet the different needs of surgeons\, being the most common ligament reconstruction\, filling bone defects\, tumour surgery and meniscal transplantation.\nResearch\, development and innovation of new products and processes are constant priorities to provide the best solution for patients by setting up different lines of R & D in the short\, medium and long term.
URL:https://ibecbarcelona.eu/event/seminario-de-id-del-banc-de-sang-i-teixits-bst-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170527T000000
DTEND;TZID=Europe/Madrid:20170528T235959
DTSTAMP:20260404T003619
CREATED:20170525T082047Z
LAST-MODIFIED:20170525T082047Z
UID:96064-1495843200-1496015999@ibecbarcelona.eu
SUMMARY:11a FESTA DE LA CIÈNCIA
DESCRIPTION:Part of the Festival Barcelona Ciència \nSaturday 27th-Sunday 28th May\, Parc de la Ciutadella\n27/05 – 17:20h\nBIOROBOTS HÍBRIDS: LA FUSIÓ DE TECNOLOGIA I LA VIDA\nMicroxerrada\, a partir de 16 anys\nA càrrec de Rafael Mestre\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 12:40h\nCREANT NANOPARTÍCULES PER A LA REGENERACIÓ DE TEIXITS\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Martín\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 13:10h\nCOM ES CREEN LES XARXES DE VASOS SANGUINIS I CAPIL·LARS?\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Malandrino\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 14:40h\nBIOSENSORS PORTÀTILS A LA CARTA\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Agostino Romero\, Institut de Bioenginyeria de Catalunya (IBEC) \nhttp://lameva.barcelona.cat/barcelonaciencia/en/
URL:https://ibecbarcelona.eu/event/11a-festa-de-la-ciencia-4/
LOCATION:Parc de la Ciutadella
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20170527
DTEND;VALUE=DATE:20170529
DTSTAMP:20260404T003619
CREATED:20170525T082047Z
LAST-MODIFIED:20170525T082348Z
UID:29647-1495843200-1496015999@ibecbarcelona.eu
SUMMARY:11a FESTA DE LA CIÈNCIA
DESCRIPTION:Part of the Festival Barcelona Ciència \nSaturday 27th-Sunday 28th May\, Parc de la Ciutadella\n27/05 – 17:20h\nBIOROBOTS HÍBRIDS: LA FUSIÓ DE TECNOLOGIA I LA VIDA\nMicroxerrada\, a partir de 16 anys\nA càrrec de Rafael Mestre\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 12:40h\nCREANT NANOPARTÍCULES PER A LA REGENERACIÓ DE TEIXITS\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Martín\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 13:10h\nCOM ES CREEN LES XARXES DE VASOS SANGUINIS I CAPIL·LARS?\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Malandrino\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 14:40h\nBIOSENSORS PORTÀTILS A LA CARTA\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Agostino Romero\, Institut de Bioenginyeria de Catalunya (IBEC) \nhttp://lameva.barcelona.cat/barcelonaciencia/en/
URL:https://ibecbarcelona.eu/event/11a-festa-de-la-ciencia/
LOCATION:Parc de la Ciutadella
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20170527
DTEND;VALUE=DATE:20170529
DTSTAMP:20260404T003619
CREATED:20170525T082047Z
LAST-MODIFIED:20170525T082047Z
UID:96062-1495843200-1496015999@ibecbarcelona.eu
SUMMARY:11a FESTA DE LA CIÈNCIA
DESCRIPTION:Part of the Festival Barcelona Ciència \nSaturday 27th-Sunday 28th May\, Parc de la Ciutadella\n27/05 – 17:20h\nBIOROBOTS HÍBRIDS: LA FUSIÓ DE TECNOLOGIA I LA VIDA\nMicroxerrada\, a partir de 16 anys\nA càrrec de Rafael Mestre\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 12:40h\nCREANT NANOPARTÍCULES PER A LA REGENERACIÓ DE TEIXITS\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Martín\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 13:10h\nCOM ES CREEN LES XARXES DE VASOS SANGUINIS I CAPIL·LARS?\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Malandrino\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 14:40h\nBIOSENSORS PORTÀTILS A LA CARTA\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Agostino Romero\, Institut de Bioenginyeria de Catalunya (IBEC) \nhttp://lameva.barcelona.cat/barcelonaciencia/en/
URL:https://ibecbarcelona.eu/event/11a-festa-de-la-ciencia-2/
LOCATION:Parc de la Ciutadella
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170527T000000
DTEND;TZID=Europe/Madrid:20170528T235959
DTSTAMP:20260404T003619
CREATED:20170525T082047Z
LAST-MODIFIED:20170525T082047Z
UID:96063-1495843200-1496015999@ibecbarcelona.eu
SUMMARY:11a FESTA DE LA CIÈNCIA
DESCRIPTION:Part of the Festival Barcelona Ciència \nSaturday 27th-Sunday 28th May\, Parc de la Ciutadella\n27/05 – 17:20h\nBIOROBOTS HÍBRIDS: LA FUSIÓ DE TECNOLOGIA I LA VIDA\nMicroxerrada\, a partir de 16 anys\nA càrrec de Rafael Mestre\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 12:40h\nCREANT NANOPARTÍCULES PER A LA REGENERACIÓ DE TEIXITS\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Martín\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 13:10h\nCOM ES CREEN LES XARXES DE VASOS SANGUINIS I CAPIL·LARS?\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Andrea Malandrino\, Institut de Bioenginyeria de Catalunya (IBEC) \n28/05 – 14:40h\nBIOSENSORS PORTÀTILS A LA CARTA\nMicroxerrada\, a partir de 16 anys\nA càrrec d’Agostino Romero\, Institut de Bioenginyeria de Catalunya (IBEC) \nhttp://lameva.barcelona.cat/barcelonaciencia/en/
URL:https://ibecbarcelona.eu/event/11a-festa-de-la-ciencia-3/
LOCATION:Parc de la Ciutadella
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170526T100000
DTEND;TZID=Europe/Madrid:20170526T110000
DTSTAMP:20260404T003619
CREATED:20170425T130338Z
LAST-MODIFIED:20170425T130338Z
UID:96053-1495792800-1495796400@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Carlos Pérez and Víctor González
DESCRIPTION:Active wetting of epithelial tissues\nCarlos Pérez\, Integrative cell and tissue dynamics group\nKey biological processes such as cancer and development are characterized by drastic transitions in tissue morphology. These rearrangements have been classically studied as a wetting problem. According to this theory\, wettability of a substrate by an epithelium is determined by the competition between cell-cell and cell-substrate adhesion energies. In contrast\, we found that\, far from a passive process\, tissue dewetting is an active process driven by tissue internal forces. Experimentally\, we reproduced epithelial dewetting by promoting a progressive formation of intercellular junctions in a monolayer of epithelial cells. Interestingly\, the formation of intercellular junctions produces an increase in cell contractility\, with the subsequent increase in traction and intercellular stress. At a certain time\, tissue tension overcomes cell-substrate maximum adhesion and the monolayer spontaneously dewets the substrate. We developed an active polar fluid model\, finding both theoretically and experimentally that critical contractility to promote wetting-dewetting transition depends on cell-substrate adhesion and\, unexpectedly\, on tissue size. As a whole\, this work generalizes wetting theory to living tissues\, unveiling unprecedented properties due to their unique active nature. \n  \nBinding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links\nVíctor González\, Cellular and molecular mechanobiology group\nFundamental processes in cell adhesion\, motility\, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers\, regulating cell migration. However\, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1–fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion\, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together\, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin–ECM links\, which may be harnessed by cells to control adhesion and migration.
URL:https://ibecbarcelona.eu/event/phd-discussions-session-carlos-perez-and-victor-gonzalez-3/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170526T100000
DTEND;TZID=Europe/Madrid:20170526T110000
DTSTAMP:20260404T003619
CREATED:20170425T130338Z
LAST-MODIFIED:20170425T130338Z
UID:96054-1495792800-1495796400@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Carlos Pérez and Víctor González
DESCRIPTION:Active wetting of epithelial tissues\nCarlos Pérez\, Integrative cell and tissue dynamics group\nKey biological processes such as cancer and development are characterized by drastic transitions in tissue morphology. These rearrangements have been classically studied as a wetting problem. According to this theory\, wettability of a substrate by an epithelium is determined by the competition between cell-cell and cell-substrate adhesion energies. In contrast\, we found that\, far from a passive process\, tissue dewetting is an active process driven by tissue internal forces. Experimentally\, we reproduced epithelial dewetting by promoting a progressive formation of intercellular junctions in a monolayer of epithelial cells. Interestingly\, the formation of intercellular junctions produces an increase in cell contractility\, with the subsequent increase in traction and intercellular stress. At a certain time\, tissue tension overcomes cell-substrate maximum adhesion and the monolayer spontaneously dewets the substrate. We developed an active polar fluid model\, finding both theoretically and experimentally that critical contractility to promote wetting-dewetting transition depends on cell-substrate adhesion and\, unexpectedly\, on tissue size. As a whole\, this work generalizes wetting theory to living tissues\, unveiling unprecedented properties due to their unique active nature. \n  \nBinding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links\nVíctor González\, Cellular and molecular mechanobiology group\nFundamental processes in cell adhesion\, motility\, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers\, regulating cell migration. However\, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1–fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion\, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together\, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin–ECM links\, which may be harnessed by cells to control adhesion and migration.
URL:https://ibecbarcelona.eu/event/phd-discussions-session-carlos-perez-and-victor-gonzalez-4/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170526T100000
DTEND;TZID=Europe/Madrid:20170526T110000
DTSTAMP:20260404T003619
CREATED:20170425T130338Z
LAST-MODIFIED:20170516T123707Z
UID:28882-1495792800-1495796400@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Carlos Pérez and Víctor González
DESCRIPTION:Active wetting of epithelial tissues\nCarlos Pérez\, Integrative cell and tissue dynamics group\nKey biological processes such as cancer and development are characterized by drastic transitions in tissue morphology. These rearrangements have been classically studied as a wetting problem. According to this theory\, wettability of a substrate by an epithelium is determined by the competition between cell-cell and cell-substrate adhesion energies. In contrast\, we found that\, far from a passive process\, tissue dewetting is an active process driven by tissue internal forces. Experimentally\, we reproduced epithelial dewetting by promoting a progressive formation of intercellular junctions in a monolayer of epithelial cells. Interestingly\, the formation of intercellular junctions produces an increase in cell contractility\, with the subsequent increase in traction and intercellular stress. At a certain time\, tissue tension overcomes cell-substrate maximum adhesion and the monolayer spontaneously dewets the substrate. We developed an active polar fluid model\, finding both theoretically and experimentally that critical contractility to promote wetting-dewetting transition depends on cell-substrate adhesion and\, unexpectedly\, on tissue size. As a whole\, this work generalizes wetting theory to living tissues\, unveiling unprecedented properties due to their unique active nature. \n  \nBinding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links\nVíctor González\, Cellular and molecular mechanobiology group\nFundamental processes in cell adhesion\, motility\, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers\, regulating cell migration. However\, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1–fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion\, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together\, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin–ECM links\, which may be harnessed by cells to control adhesion and migration.
URL:https://ibecbarcelona.eu/event/phd-discussions-session-carlos-perez-and-victor-gonzalez/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170526T100000
DTEND;TZID=Europe/Madrid:20170526T110000
DTSTAMP:20260404T003619
CREATED:20170425T130338Z
LAST-MODIFIED:20170425T130338Z
UID:96048-1495792800-1495796400@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Carlos Pérez and Víctor González
DESCRIPTION:Active wetting of epithelial tissues\nCarlos Pérez\, Integrative cell and tissue dynamics group\nKey biological processes such as cancer and development are characterized by drastic transitions in tissue morphology. These rearrangements have been classically studied as a wetting problem. According to this theory\, wettability of a substrate by an epithelium is determined by the competition between cell-cell and cell-substrate adhesion energies. In contrast\, we found that\, far from a passive process\, tissue dewetting is an active process driven by tissue internal forces. Experimentally\, we reproduced epithelial dewetting by promoting a progressive formation of intercellular junctions in a monolayer of epithelial cells. Interestingly\, the formation of intercellular junctions produces an increase in cell contractility\, with the subsequent increase in traction and intercellular stress. At a certain time\, tissue tension overcomes cell-substrate maximum adhesion and the monolayer spontaneously dewets the substrate. We developed an active polar fluid model\, finding both theoretically and experimentally that critical contractility to promote wetting-dewetting transition depends on cell-substrate adhesion and\, unexpectedly\, on tissue size. As a whole\, this work generalizes wetting theory to living tissues\, unveiling unprecedented properties due to their unique active nature. \n  \nBinding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links\nVíctor González\, Cellular and molecular mechanobiology group\nFundamental processes in cell adhesion\, motility\, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers\, regulating cell migration. However\, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1–fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion\, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together\, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin–ECM links\, which may be harnessed by cells to control adhesion and migration.
URL:https://ibecbarcelona.eu/event/phd-discussions-session-carlos-perez-and-victor-gonzalez-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170524T100000
DTEND;TZID=Europe/Madrid:20170524T130000
DTSTAMP:20260404T003619
CREATED:20170324T101319Z
LAST-MODIFIED:20170324T101319Z
UID:96024-1495620000-1495630800@ibecbarcelona.eu
SUMMARY:Good practices in a multidisciplinary lab
DESCRIPTION:Training activity in Scientific tools & techniques. \nThe objective of this workshop is to acquire the good practices necessary in a multidisciplinary laboratory to ensure the highest quality of the results. \nDates:  \nThe workshop will be offered twice a year. \n\n24th May\, from 10 to 13pm\nOctober\n\nTarget group:  \nVocational training Students\, Undergraduate students\, Master students and PhDs in their first year. \nProvider: Internal Trainer\, IBEC Risk PRevention representatives.
URL:https://ibecbarcelona.eu/event/good-practices-in-a-multidisciplinary-lab-2/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170524T100000
DTEND;TZID=Europe/Madrid:20170524T130000
DTSTAMP:20260404T003619
CREATED:20170324T101319Z
LAST-MODIFIED:20170425T130432Z
UID:28665-1495620000-1495630800@ibecbarcelona.eu
SUMMARY:Good practices in a multidisciplinary lab
DESCRIPTION:Training activity in Scientific tools & techniques. \nThe objective of this workshop is to acquire the good practices necessary in a multidisciplinary laboratory to ensure the highest quality of the results. \nDates:  \nThe workshop will be offered twice a year. \n\n24th May\, from 10 to 13pm\nOctober\n\nTarget group:  \nVocational training Students\, Undergraduate students\, Master students and PhDs in their first year. \nProvider: Internal Trainer\, IBEC Risk PRevention representatives.
URL:https://ibecbarcelona.eu/event/good-practices-in-a-multidisciplinary-lab/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170523T110000
DTEND;TZID=Europe/Madrid:20170523T130000
DTSTAMP:20260404T003619
CREATED:20170324T102450Z
LAST-MODIFIED:20170324T102450Z
UID:28661-1495537200-1495544400@ibecbarcelona.eu
SUMMARY:Technology Transfer
DESCRIPTION:Training activity in Innovation skills. \nThe objective of the session will be to understand what the effective technology transfer is\, and what opportunities and constrains brings to a researcher. \nDates:   \n23rd May 2017\, from 11 to 13H. In person class sessions: 2 hours \n Target group:   \nAll IBEC members
URL:https://ibecbarcelona.eu/event/technology-transfer/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170523T110000
DTEND;TZID=Europe/Madrid:20170523T130000
DTSTAMP:20260404T003619
CREATED:20170324T102450Z
LAST-MODIFIED:20170324T102450Z
UID:96023-1495537200-1495544400@ibecbarcelona.eu
SUMMARY:Technology Transfer
DESCRIPTION:Training activity in Innovation skills. \nThe objective of the session will be to understand what the effective technology transfer is\, and what opportunities and constrains brings to a researcher. \nDates:   \n23rd May 2017\, from 11 to 13H. In person class sessions: 2 hours \n Target group:   \nAll IBEC members
URL:https://ibecbarcelona.eu/event/technology-transfer-2/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170519T100000
DTEND;TZID=Europe/Madrid:20170519T110000
DTSTAMP:20260404T003619
CREATED:20170425T125954Z
LAST-MODIFIED:20170425T125954Z
UID:96045-1495188000-1495191600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Verena Ruprecht
DESCRIPTION:Tuning cell and tissue dynamics by the biomechanical microenvironment\nDr. Verena Ruprecht\, Cell & Developmental Biology program\, CRG\, Barcelona (Spain)\nResearch in our lab is focused on the control of cell and tissue dynamics in 3D environments. We study how single cells process multifactorial mechanochemical information from their surrounding and generate adaptive output dynamics such as shape change\, cell polarization and migration that collectively impact on tissue development and morphogenesis. We use Zebrafish embryos and primary embryonic progenitor stem cells as a model system to study molecular and cellular mechanisms driving complex three-dimensional tissue rearrangements and patterning in the embryo. Our lab follows a highly interdisciplinary approach combining molecular and cell biological tools with quantitative imaging approaches and advanced fluorescence microscopy. We implement a dual experiment strategy of in vivo experiments and minimalistic in vitro culture assays that allow for reconstituting the complexity of tissue morphogenesis in simplified environments.\nIn this talk I will specifically focus on how the  3D cellular microenvironment modulates cytoskeletal dynamics and motile cell behaviour and how a combination of physics and biology can help to elucidate generic patterns in cell motility.
URL:https://ibecbarcelona.eu/event/ibec-seminar-verena-ruprecht-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170519T100000
DTEND;TZID=Europe/Madrid:20170519T110000
DTSTAMP:20260404T003619
CREATED:20170425T125954Z
LAST-MODIFIED:20170425T125954Z
UID:96046-1495188000-1495191600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Verena Ruprecht
DESCRIPTION:Tuning cell and tissue dynamics by the biomechanical microenvironment\nDr. Verena Ruprecht\, Cell & Developmental Biology program\, CRG\, Barcelona (Spain)\nResearch in our lab is focused on the control of cell and tissue dynamics in 3D environments. We study how single cells process multifactorial mechanochemical information from their surrounding and generate adaptive output dynamics such as shape change\, cell polarization and migration that collectively impact on tissue development and morphogenesis. We use Zebrafish embryos and primary embryonic progenitor stem cells as a model system to study molecular and cellular mechanisms driving complex three-dimensional tissue rearrangements and patterning in the embryo. Our lab follows a highly interdisciplinary approach combining molecular and cell biological tools with quantitative imaging approaches and advanced fluorescence microscopy. We implement a dual experiment strategy of in vivo experiments and minimalistic in vitro culture assays that allow for reconstituting the complexity of tissue morphogenesis in simplified environments.\nIn this talk I will specifically focus on how the  3D cellular microenvironment modulates cytoskeletal dynamics and motile cell behaviour and how a combination of physics and biology can help to elucidate generic patterns in cell motility.
URL:https://ibecbarcelona.eu/event/ibec-seminar-verena-ruprecht-3/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170519T100000
DTEND;TZID=Europe/Madrid:20170519T110000
DTSTAMP:20260404T003619
CREATED:20170425T125954Z
LAST-MODIFIED:20170425T125954Z
UID:28878-1495188000-1495191600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Verena Ruprecht
DESCRIPTION:Tuning cell and tissue dynamics by the biomechanical microenvironment\nDr. Verena Ruprecht\, Cell & Developmental Biology program\, CRG\, Barcelona (Spain)\nResearch in our lab is focused on the control of cell and tissue dynamics in 3D environments. We study how single cells process multifactorial mechanochemical information from their surrounding and generate adaptive output dynamics such as shape change\, cell polarization and migration that collectively impact on tissue development and morphogenesis. We use Zebrafish embryos and primary embryonic progenitor stem cells as a model system to study molecular and cellular mechanisms driving complex three-dimensional tissue rearrangements and patterning in the embryo. Our lab follows a highly interdisciplinary approach combining molecular and cell biological tools with quantitative imaging approaches and advanced fluorescence microscopy. We implement a dual experiment strategy of in vivo experiments and minimalistic in vitro culture assays that allow for reconstituting the complexity of tissue morphogenesis in simplified environments.\nIn this talk I will specifically focus on how the  3D cellular microenvironment modulates cytoskeletal dynamics and motile cell behaviour and how a combination of physics and biology can help to elucidate generic patterns in cell motility.
URL:https://ibecbarcelona.eu/event/ibec-seminar-verena-ruprecht/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170519T100000
DTEND;TZID=Europe/Madrid:20170519T110000
DTSTAMP:20260404T003619
CREATED:20170425T125954Z
LAST-MODIFIED:20170425T125954Z
UID:96047-1495188000-1495191600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Verena Ruprecht
DESCRIPTION:Tuning cell and tissue dynamics by the biomechanical microenvironment\nDr. Verena Ruprecht\, Cell & Developmental Biology program\, CRG\, Barcelona (Spain)\nResearch in our lab is focused on the control of cell and tissue dynamics in 3D environments. We study how single cells process multifactorial mechanochemical information from their surrounding and generate adaptive output dynamics such as shape change\, cell polarization and migration that collectively impact on tissue development and morphogenesis. We use Zebrafish embryos and primary embryonic progenitor stem cells as a model system to study molecular and cellular mechanisms driving complex three-dimensional tissue rearrangements and patterning in the embryo. Our lab follows a highly interdisciplinary approach combining molecular and cell biological tools with quantitative imaging approaches and advanced fluorescence microscopy. We implement a dual experiment strategy of in vivo experiments and minimalistic in vitro culture assays that allow for reconstituting the complexity of tissue morphogenesis in simplified environments.\nIn this talk I will specifically focus on how the  3D cellular microenvironment modulates cytoskeletal dynamics and motile cell behaviour and how a combination of physics and biology can help to elucidate generic patterns in cell motility.
URL:https://ibecbarcelona.eu/event/ibec-seminar-verena-ruprecht-4/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170518T190000
DTEND;TZID=Europe/Madrid:20170518T233000
DTSTAMP:20260404T003619
CREATED:20170425T133608Z
LAST-MODIFIED:20170425T133608Z
UID:96056-1495134000-1495150200@ibecbarcelona.eu
SUMMARY:PhD Committee: Laser Tag
DESCRIPTION:Change your labcoat for a laser gun and fight with your team for victory!\nPlay-Point (Comte Borrell 88)\nThe meeting time will be 7.00pm. It’s only 2€ for IBEC members and 10€ for non-IBEC (give the money to PhD committee before May 15th).\nAfterwards\, around 9pm\, we will go for some tapas and drinks (place to be decided by the winning team). \nTo register please fill the Doodle. Write your email with the number of people you will come (e.g. David + 1\, ddd@ibecbarcelona.eu).
URL:https://ibecbarcelona.eu/event/phd-committee-laser-tag-2/
LOCATION:Play-Point\, Comte Borrell 88\, Barcelona\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170518T190000
DTEND;TZID=Europe/Madrid:20170518T233000
DTSTAMP:20260404T003619
CREATED:20170425T133608Z
LAST-MODIFIED:20170425T133608Z
UID:96057-1495134000-1495150200@ibecbarcelona.eu
SUMMARY:PhD Committee: Laser Tag
DESCRIPTION:Change your labcoat for a laser gun and fight with your team for victory!\nPlay-Point (Comte Borrell 88)\nThe meeting time will be 7.00pm. It’s only 2€ for IBEC members and 10€ for non-IBEC (give the money to PhD committee before May 15th).\nAfterwards\, around 9pm\, we will go for some tapas and drinks (place to be decided by the winning team). \nTo register please fill the Doodle. Write your email with the number of people you will come (e.g. David + 1\, ddd@ibecbarcelona.eu).
URL:https://ibecbarcelona.eu/event/phd-committee-laser-tag-3/
LOCATION:Play-Point\, Comte Borrell 88\, Barcelona\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170518T190000
DTEND;TZID=Europe/Madrid:20170518T233000
DTSTAMP:20260404T003619
CREATED:20170425T133608Z
LAST-MODIFIED:20170425T133608Z
UID:96058-1495134000-1495150200@ibecbarcelona.eu
SUMMARY:PhD Committee: Laser Tag
DESCRIPTION:Change your labcoat for a laser gun and fight with your team for victory!\nPlay-Point (Comte Borrell 88)\nThe meeting time will be 7.00pm. It’s only 2€ for IBEC members and 10€ for non-IBEC (give the money to PhD committee before May 15th).\nAfterwards\, around 9pm\, we will go for some tapas and drinks (place to be decided by the winning team). \nTo register please fill the Doodle. Write your email with the number of people you will come (e.g. David + 1\, ddd@ibecbarcelona.eu).
URL:https://ibecbarcelona.eu/event/phd-committee-laser-tag-4/
LOCATION:Play-Point\, Comte Borrell 88\, Barcelona\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170518T190000
DTEND;TZID=Europe/Madrid:20170518T233000
DTSTAMP:20260404T003619
CREATED:20170425T133608Z
LAST-MODIFIED:20170425T133608Z
UID:28903-1495134000-1495150200@ibecbarcelona.eu
SUMMARY:PhD Committee: Laser Tag
DESCRIPTION:Change your labcoat for a laser gun and fight with your team for victory!\nPlay-Point (Comte Borrell 88)\nThe meeting time will be 7.00pm. It’s only 2€ for IBEC members and 10€ for non-IBEC (give the money to PhD committee before May 15th).\nAfterwards\, around 9pm\, we will go for some tapas and drinks (place to be decided by the winning team). \nTo register please fill the Doodle. Write your email with the number of people you will come (e.g. David + 1\, ddd@ibecbarcelona.eu).
URL:https://ibecbarcelona.eu/event/phd-committee-laser-tag/
LOCATION:Play-Point\, Comte Borrell 88\, Barcelona\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170518T080000
DTEND;TZID=Europe/Madrid:20170518T170000
DTSTAMP:20260404T003619
CREATED:20170324T091531Z
LAST-MODIFIED:20170324T091531Z
UID:96019-1495094400-1495126800@ibecbarcelona.eu
SUMMARY:Mentoring skills for Senior Scientists
DESCRIPTION:Training activity in Leadership&management skills. \nThe aim of the two workshops is to prepare Senior Scientists for their roles of Mentor in the IBEC mentoring programme. They will learn key skills to encourage and support the learning of their mentees and consider how to manage the different stages in the process. They will also identify what their personal developmental objectives are in their own career paths. \nDates:  \n18th and 24th May\, from 9.30 -1:30pm\nIn person class sessions = 8 hours in two half days + Pre-reading material \nTarget group: \nGroup Leaders participating in the IBEC’s Mentoring Programme. \nProvider: Louise Schubert. \n 
URL:https://ibecbarcelona.eu/event/mentoring-skills-for-senior-scientists-2/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170518T080000
DTEND;TZID=Europe/Madrid:20170518T170000
DTSTAMP:20260404T003619
CREATED:20170324T091531Z
LAST-MODIFIED:20170324T102524Z
UID:28642-1495094400-1495126800@ibecbarcelona.eu
SUMMARY:Mentoring skills for Senior Scientists
DESCRIPTION:Training activity in Leadership&management skills. \nThe aim of the two workshops is to prepare Senior Scientists for their roles of Mentor in the IBEC mentoring programme. They will learn key skills to encourage and support the learning of their mentees and consider how to manage the different stages in the process. They will also identify what their personal developmental objectives are in their own career paths. \nDates:  \n18th and 24th May\, from 9.30 -1:30pm\nIn person class sessions = 8 hours in two half days + Pre-reading material \nTarget group: \nGroup Leaders participating in the IBEC’s Mentoring Programme. \nProvider: Louise Schubert. \n 
URL:https://ibecbarcelona.eu/event/mentoring-skills-for-senior-scientists/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170512T110000
DTEND;TZID=Europe/Madrid:20170512T140000
DTSTAMP:20260404T003619
CREATED:20170224T122921Z
LAST-MODIFIED:20170801T105113Z
UID:27780-1494586800-1494597600@ibecbarcelona.eu
SUMMARY:reSearch4Talent 2017
DESCRIPTION:reSearch4Talent 2017\nOn Friday 12th May 2017 we’ll open our doors again to undergraduate and masters students interested in a research career. \nThis will be the third edition of reSearch4Talent. \n\nPROGRAMME:\n11:00 Welcome\n11:15 Director’s talk\, “What is IBEC?” and overview of research groups\n11:50 HR Speech\n12:00 Careers Fair: a chance for participants to mingle and chat with our researchers\n13:00 – 14:00 Lab visits \n\nVENUE:\nInstitute for Bioengineering of Catalonia (IBEC)\nDolors Aleu Room\nParc Científic de Barcelona (PCB)\nC. Baldiri Reixac\, 4-8\, Barcelona \nMore details here.
URL:https://ibecbarcelona.eu/event/research4talent-2017/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170512T110000
DTEND;TZID=Europe/Madrid:20170512T140000
DTSTAMP:20260404T003619
CREATED:20170224T122921Z
LAST-MODIFIED:20170224T122921Z
UID:96005-1494586800-1494597600@ibecbarcelona.eu
SUMMARY:reSearch4Talent 2017
DESCRIPTION:reSearch4Talent 2017\nOn Friday 12th May 2017 we’ll open our doors again to undergraduate and masters students interested in a research career. \nThis will be the third edition of reSearch4Talent. \n\nPROGRAMME:\n11:00 Welcome\n11:15 Director’s talk\, “What is IBEC?” and overview of research groups\n11:50 HR Speech\n12:00 Careers Fair: a chance for participants to mingle and chat with our researchers\n13:00 – 14:00 Lab visits \n\nVENUE:\nInstitute for Bioengineering of Catalonia (IBEC)\nDolors Aleu Room\nParc Científic de Barcelona (PCB)\nC. Baldiri Reixac\, 4-8\, Barcelona \nMore details here.
URL:https://ibecbarcelona.eu/event/research4talent-2017-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170512T110000
DTEND;TZID=Europe/Madrid:20170512T140000
DTSTAMP:20260404T003619
CREATED:20170224T122921Z
LAST-MODIFIED:20170224T122921Z
UID:96012-1494586800-1494597600@ibecbarcelona.eu
SUMMARY:reSearch4Talent 2017
DESCRIPTION:reSearch4Talent 2017\nOn Friday 12th May 2017 we’ll open our doors again to undergraduate and masters students interested in a research career. \nThis will be the third edition of reSearch4Talent. \n\nPROGRAMME:\n11:00 Welcome\n11:15 Director’s talk\, “What is IBEC?” and overview of research groups\n11:50 HR Speech\n12:00 Careers Fair: a chance for participants to mingle and chat with our researchers\n13:00 – 14:00 Lab visits \n\nVENUE:\nInstitute for Bioengineering of Catalonia (IBEC)\nDolors Aleu Room\nParc Científic de Barcelona (PCB)\nC. Baldiri Reixac\, 4-8\, Barcelona \nMore details here.
URL:https://ibecbarcelona.eu/event/research4talent-2017-3/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
END:VCALENDAR