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DTSTART;TZID=Europe/Madrid:20210218T104000
DTEND;TZID=Europe/Madrid:20210218T140000
DTSTAMP:20260406T021809
CREATED:20210218T075645Z
LAST-MODIFIED:20210218T075756Z
UID:81854-1613644800-1613656800@ibecbarcelona.eu
SUMMARY:Crafting a Winning ERC Proposal
DESCRIPTION:Do not miss the workshop “Crafting a Winning ERC Proposal”\, with the participation of ERC Grantee and Panel Member Samuel Sánchez from IBEC\, as well as other grantees and ERC Officers. \n \nThis is an event organised by “Academia Joven de España”. \nConnection link here
URL:https://ibecbarcelona.eu/event/crafting-a-winning-erc-proposal/
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210212
DTEND;VALUE=DATE:20210213
DTSTAMP:20260406T021809
CREATED:20210222T131156Z
LAST-MODIFIED:20210222T131156Z
UID:81963-1613088000-1613174399@ibecbarcelona.eu
SUMMARY:100tífiques
DESCRIPTION:On the occasion of the International Day of Woman and Girls in Science researchers from IBEC went to different catalan schools to give a presentation of women in science to encourage all kids to study STEAM digrees. \nFurthermore\, as IBEC has a partnership with the elementary school “Escola Gayarre” within the frame of the “Magnet Projects” some of our researchers visited their classrooms and also gave an oran exposition of women in science.
URL:https://ibecbarcelona.eu/event/100tifiques/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210205T100000
DTEND;TZID=Europe/Madrid:20210205T120000
DTSTAMP:20260406T021809
CREATED:20210107T101425Z
LAST-MODIFIED:20210203T120455Z
UID:80728-1612519200-1612526400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Jordi Alcaraz
DESCRIPTION:Improving lung cancer management by reengineering tumor-associated fibroblasts\nJordi Alcaraz\, UB facultat de Medicina & IBEC Associated Researcher \nLung cancer is the leading cause of cancer death due in part to subtoptimal patient responses to current therapies\, which have been largely designed to targeting cancer cell abnormalities. However\, there is a paradigm shift in cancer research that considers tumors as abnormal organs\, thereby acknowledging the key contribution to tumor progression provided by fibroblasts and other non-cancerous stromal cells that shape the tumor mechanical and biochemical ecosystem. \nOur group pioneered the study of tumor-associated fibroblasts (TAFs) in lung cancer in Spain in collaboration with oncologists at the Hospital Clínic. I will provide an overview of our efforts in unveiling how TAFs contribute to tumor progression in major lung cancer subtypes and in identifying how can we target such contributions with new therapeutic strategies\, including the development of novel preclinical models. Moreover\, I will describe our efforts to define novel TAF-related prognostic and/or diagnostic biomarkers. Part of this work is carried out in collaboration with pharmaceutical companies. I will also briefly summarize ongoing collaborations with IBEC groups in these topics. \nThis seminar will take place online at the GoToMeeting platform \nKnow more about Jordi Alcaraz’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-jordi-alcaraz/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210204T110000
DTEND;TZID=Europe/Madrid:20210204T140000
DTSTAMP:20260406T021809
CREATED:20210203T122428Z
LAST-MODIFIED:20210203T122448Z
UID:81343-1612436400-1612447200@ibecbarcelona.eu
SUMMARY:Nanodía Mundial Contra el Cáncer
DESCRIPTION:El Nanodía Mundial Contra el Cáncer es un evento organizado en el marco del Día Mundial contra el Cáncer donde se darán a conocer las últimas innovaciones en materia de NANOMEDICINA contra el CÁNCER\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \nUn año más\, expertos en NANOMEDICINA de diferentes campos -investigadores\, empresarios\, médicos oncólogos\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la NANOMEDICINA significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer y como podemos contribuir en la misión Europea contra el cáncer. \nIniciado bajo el nombre de NANO WORLD CANCER DAY\, NANOMED Spain organiza la sexta edición\, este año de manera virtual con la colaboración del Institut Germans Trias i Pujol (IGTP). \nInscripciones: http://nanomedspain.net/jornada_ndcc/
URL:https://ibecbarcelona.eu/event/nanodia-mundial-contra-el-cancer/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210129T100000
DTEND;TZID=Europe/Madrid:20210129T120000
DTSTAMP:20260406T021809
CREATED:20210107T102348Z
LAST-MODIFIED:20210125T074321Z
UID:80732-1611914400-1611921600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Gerard Rubí and Ignasi Ferrer
DESCRIPTION:Development of an in vitro three-dimensional colorectal tumor model for drug screening\nGerard Rubí\, Biomaterials for Regenerative Therapies \nThe majority of morphogenetic and pathological processes are driven by cells responding to the surrounding matrix cues\, including matrix composition\, architecture\, and mechanical properties. Despite the increased evidence of extracellular matrix (ECM) properties\, in vitro substitutes still fail to effectively mimic the native microenvironment. In this study\, we aim to develop and characterize cell-derived extracellular matrices (CDMs) obtained through a protein deposition from human mesenchymal stem cells cultured in sacrificial 3D scaffold templates of poly-lactic acid (PLA) microcarriers. Obtained decellularized CDMs closely mimic biochemical\, physical\, and mechanical properties of native tissues’ ECM. The produced novel CDMs\, are currently tested as a 3D cell culture platform for disease modelling. This is achieved through CDMs repopulation with colorectal cancer cells and cancer associated fibroblasts (CAFs). The new 3D CDMs-cancer platform will provide an in vitro tumor model to study the cells-ECM interactions and potential therapeutic targets\, to finally serve as a drug-screening platform for personalized medicine. \nNovel m-Health and multimodal physiological biomarkers for non-invasive monitoring and home healthcare of Obstructive Sleep Apnea and COPD patients with comorbidities\nIgnasi Ferrer\, Biomedical Signal Processing and Interpretation \nObstructive sleep apnea (OSA) is a sleep disorder in which repetitive upper airway obstructive events occur during sleep. These events can induce hypoxia\, which is a risk factor for multiple cardiovascular and cerebrovascular diseases. OSA is also known to be position-dependent in some patients\, which is referred to as positional OSA (pOSA). The gold-standard technique for diagnosing OSA is nocturnal polysomnography (PSG)\, which consists in recording multiple physiological signals while the patient is asleep in a hospital sleep lab. However\, PSG has some important limitations\, such as the high cost of the diagnostic test; the diagnosis is usually performed with a one-night sleep assessment\, which does not account for the variability of sleep performance in the patient; and the sleep quality varies from that at home\, because the patient has to sleep in a different bed connected to a lot of electrodes and wires. \nIn this study we aim to study how smartphones could be used to diagnose and monitor sleep apnea at home. Since smartphones are worldwide available devices\, with a lot of embedded sensors\, they appear as a feasible mHealth tools that could help overcome these limitations. \nThe PhD discussions session will be held ONLINE at the GoToMeeting platform
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-gerard-rubi-and-ignasi-ferrer/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210115T110000
DTEND;TZID=Europe/Madrid:20210115T130000
DTSTAMP:20260406T021809
CREATED:20210111T111039Z
LAST-MODIFIED:20210113T080556Z
UID:80775-1610708400-1610715600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Maria Blancas Muñoz
DESCRIPTION:Knowing what you know. A pedagogical model based on learners’ metacognitive abilities\nMaria Blancas Muñoz\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) \nThis thesis defense will be held online next 15th January at 11\, via “zoom”\, using this link.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-maria-blancas-munoz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210115T100000
DTEND;TZID=Europe/Madrid:20210115T120000
DTSTAMP:20260406T021809
CREATED:20201116T152332Z
LAST-MODIFIED:20210108T115741Z
UID:79746-1610704800-1610712000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Silvia Muro
DESCRIPTION:Targeted drug delivery: fundamental aspects and translational applications\n \nSilvia Muro\, IBEC \nThe design of strategies to enable efficient and safe delivery of therapeutic agents to areas of the body requiring intervention is an active research field. Therapeutic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the administration site into a subjacent or far-away tissue. Once within the tissue or body compartment of interest\, most targets for therapeutic intervention relate to particular sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, requiring strategies to achieve the final destination of interest. Using polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and/or into compartments of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and transport by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). \nIn this presentation\, I will focus on reviewing some of our most recent efforts in this field. The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems. \nThis seminar will take place online at the GoToMeeting platform \nKnow more about Silvia Muro’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-silvia-muro/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201221T110000
DTEND;TZID=Europe/Madrid:20201221T130000
DTSTAMP:20260406T021809
CREATED:20201214T081415Z
LAST-MODIFIED:20201214T081428Z
UID:80334-1608548400-1608555600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Laia Lidón Gil
DESCRIPTION:Regulación de la expresión de PrPC como elemento clave en las modificaciones de tau en la enfermedad de Alzheimer\nLaia Lidón\, Molecular and Cellular Neurobiotechnology \nLa enfermedad de Alzheimer (EA) es la causa más común de demencia y tiene una elevada prevalencia a nivel mundial. Se caracteriza por un deterioro cognitivo progresivo y muestra como principales rasgos neuropatológicos la presencia de placas seniles enriquecidas en βamiloide y ovillos neurofibrilares intracelulares constituidos por la proteína tau hiperfosforilada. Una precisa regulación de la fosforilación de tau es esencial para que la proteína ejerza sus funciones normales\, ya que su hiperfosforilación interrumpe procesos neuronales básicos como el transporte axonal. \nPor otro lado\, la proteína priónica celular (PrPC) es una glicoproteína de unión a membrana que en humanos se expresa mayoritariamente en el sistema nervioso central a partir de un único gen\, PRNP. Sus funciones fisiológicas abarcan un conjunto de propiedades neuroprotectoras como la regulación de la homeostasis del calcio\, la actividad anti-apoptótica y la capacidad antioxidante. \nEn los últimos años\, el interés por la PrPC y su implicación en diversas enfermedades neurodegenerativas ha ido en aumento a medida que se han ido conociendo los múltiples rasgos comunes a nivel molecular y/o neuropatológico entre PrPC y dichas enfermedades. Por\nejemplo\, se ha descrito que PrPC interacciona directamente con las proteínas tau\, Aβ y αsinucleína participando así en diversos procesos patológicos y vías de señalización. Es por ello que PrPC ha sido asociada con la EA y otras taupatías o la enfermedad de Parkinson. \nEn este sentido\, se ha descrito que el aumento de expresión de PrPC provoca una reducción de los niveles de tau y una menor susceptibilidad a la fosforilación en modelos experimentales de EA. Además\, ha sido demostrado que durante el curso de la EA se producen cambios de expresión en el perfil de PrPC habiendo un incremento notable en estadios iniciales de la enfermedad\, mientras que en estadios avanzados la expresión de PrPC disminuye coincidiendo con el incremento de depósitos de ptau. Este hecho\, sugiere que PrPC podría estar ejerciendo un rol neuroprotector en las fases iniciales de la enfermedad y\, en cambio\, la reducción de su expresión en fases avanzadas contribuiría a la neurodegeneración y a la progresión de la patología. \nA pesar de ello\, se desconoce cuáles son los desencadenantes de los cambios de expresión de PRNP en la enfermedad y\, por este motivo\, uno de los objetivos principales de la presente tesis ha sido analizar dichos factores. Hemos estudiado diversos estímulos asociados a la EA que pueden estar implicados en la regulación transcripcional de PRNP en etapas iniciales de la enfermedad y nuestros resultados indican que el incremento celular de los niveles de tau promueve la activación del promotor de PRNP. Además\, hemos descrito que la vía de señalización JNK-c-jun-AP1 es la principalmente implicada en la activación del promotor de PRNP por tau. \nPor otro lado\, diversos estudios sugieren que PrPC participa en la diferenciación neuronal de progenitores neuronales\, un proceso altamente influenciado por la actividad de la glucógeno sintasa quinasa-3beta (GSK3β)\, siendo esta inhibida por PrPC . Múltiples trabajos han descrito un desequilibrio en la expresión de las diferentes isoformas de tau (tau3R y tau4R) derivadas del splicing diferencial que sufre el gen de tau\, MAPT\, en enfermedades que cursan acúmulo de tau\, como la EA. En dichas enfermedades también se han encontrado niveles alterados de diversas quinasas\, y entre ellas se encuentra la GSK3β\, que además de incidir sobre la hiperfosforilación de tau\, está directamente implicada en el splicing alternativo de MAPT. Por ello\, otro de los propósitos del presente estudio ha sido analizar la intervención de PrPC \, no solo en la fosforilación de tau y en el mantenimiento de sus niveles de expresión\, sino también\nen la generación de las diferentes isoformas tau3R y tau4R. Mediante el uso de animales transgénicos\, muestras humanas de pacientes con EA y modelos experimentales de estudio de la PrPC \, nuestros resultados corroboran la implicación de PrPC en el splicing alternativo del exón 10 de tau a través de su papel inhibidor de la actividad GSK3β. \n\nThis thesis defense will be held online next 21st December at 11\, in order to be able to attend the defense\, you have to write an email to: doctorat.biologia@ub.edu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-laia-lidon-gil/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201215T120000
DTEND;TZID=Europe/Madrid:20201215T140000
DTSTAMP:20260406T021809
CREATED:20201203T074210Z
LAST-MODIFIED:20201214T113928Z
UID:80200-1608033600-1608040800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Sock Ching Low
DESCRIPTION:Giving Centre Stage to Top-Down Inhibitory Mechanisms for Selective Attention\nSock Ching Low\, SPECS (Synthetic\, Perceptive\, Emotive and Cognitive Systems) \nSelective attention determines the sensory signals that are processed at higher levels at the expense of others and is biased by higher-order brain regions which anticipate task-relevant stimuli and increase neural sensitivity to them in the sensory cortex. Often\, this is thought to occur through excitation of selected neurons\, but some studies have suggested that it is not the full description of the process. Increasingly\, evidence has pointed to an alternative\, top-down inhibitory biasing mechanism. Here\, we investigated such an inhibitory model of attention. We first showed how sensitivity to stimulus features known to be task-irrelevant are reduced through top-down suppression. Secondly\, we demonstrated a biologically grounded spiking model’s ability to modulate information processing and benchmarked it to physiology. Lastly\, we explored the interaction between the excitatory and inhibitory models of top-down attention in a foraging agent. Our results support the inhibitory model of top-down attention as a biological attentional mechanism and show how it fits into the current zeitgeist of top-down attentional mechanisms. \nThis thesis defense will be held online using “Zoom” using this link.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-sock-ching-low/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201211T140000
DTEND;TZID=Europe/Madrid:20201211T170000
DTSTAMP:20260406T021809
CREATED:20201209T121743Z
LAST-MODIFIED:20201210T124757Z
UID:80270-1607695200-1607706000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Elena Lantero
DESCRIPTION:Targeting strategies against Plasmodium and practical applications: blocking parasite development with heparin derivatives and identifying new aptamers for diagnosis\nElena Lantero\, Nanomalaria Group\nThis thesis defense will take place ONLINE on the 11th December at 14.00 using the “BB Collaborate” streaming platform.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-elena-lantero/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201211T100000
DTEND;TZID=Europe/Madrid:20201211T120000
DTSTAMP:20260406T021809
CREATED:20201116T151624Z
LAST-MODIFIED:20201130T163347Z
UID:79742-1607680800-1607688000@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Nimesh Ramesh and Sock Ching Low
DESCRIPTION:Microfluidic device for engineering 3D epithelial monolayers with controlled pressure\nNimesh Ramesh\, Integrative Cell and Tissue Dynamics \nThe remarkable feature of the epithelial sheets is to form specialized 3D structures suited to their physiological roles\, such as highly branched structures in the lungs\, drastic shape changes during embryonic development\, or self-organizing organoids. These tissues are distinctive not just in the forms cells assume\, but also in function. To achieve this\, tissues and the cells in them exhibit coordinated behavior across the spatial and temporal scale. In a sense\, 3D epithelia resemble an active material that adapts and changes in response to its biophysical-chemical stimuli like gene expression\, morphogen gradients\, and lumen pressure. A rheological study of the epithelia would provide unique insight on two fronts. First\, to understand the fundamental physical rules of the biology\, and second for inspiration of new engineering tools and design principles. \nOur study focuses on the tissue response to physical forces\, specifically pressure\, tension\, and curvature. We have fabricated a microfluidic setup to subject epithelial tissues to lumen pressure at different spatial and temporal scales. The epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying controlled pressure\, the monolayer delaminates into a spherical cap (dome). Laplace law for spherical shells allows us to compute tension in the 3D structure with applied pressure and the radius of the dome. \nThis microfluidic device helps us to characterize the 3D epithelial shape along with the mapping of physical forces. Here\, we demonstrate that the device can subject MDCK epithelial cells to a range of lumen pressure at different rates. Drastic reduction in pressure results in tissue collapsing into wrinkles; showing buckling tendency of the tissue under compression. We think that our device enables studying geometrical and biophysical constraints of tissues and unravel emergent phenomena in tissues. \n\nSaccade rate is associated with number of items in working memory\nSock Shing Low\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) \nWorking memory has been shown to rely on theta oscillations for item representations\, and the successful recall of items depends greatly on theta’s phase during both encoding and recall. At the same time\, it has been observed that saccadic eye movements during visual exploration trigger theta phase-resets\, raising the question of whether the neuronal substrates of mnemonic processing rely on motor-evoked responses. To quantify the relationship between saccadic eye movements and working memory load\, we tested human participants performing an n-back Sternberg auditory task in combination with a colour-based catch detection task. We observed a task-specific interference in performance and an increase in saccade rate when both tasks were carried out simultaneously. Saccade rate also increased concurrently with working memory load in the Sternberg task’s pre-response stage\, reflecting its hypothesised role in memory recall. Our results suggest an interplay between saccades and hippocampal theta during retrieval of items in working memory. \nThe PhD discussions session will be held ONLINE at the GoToMeeting platform
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-nimesh-ramesh-and-sock-ching-low/
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201210T153000
DTEND;TZID=Europe/Madrid:20201210T170000
DTSTAMP:20260406T021809
CREATED:20201209T122744Z
LAST-MODIFIED:20201210T124825Z
UID:80273-1607614200-1607619600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Anna Vila Giraut
DESCRIPTION:Hydrogel co-networks of gelatin methacryloyl and poly(ethylene glycol)diacrylate sustain 3D functional in vitro models of intestinal mucosa\nAnna Vila Giraut\, Biomimetic systems for cell engineering Group\nConventional in vitro cell culture models do not possess the complexity that the native tissues offer. Because of this\, the functional properties of the tissues are not properly mimicked\, which causes poorly predictive capabilities. Engineered tissues\, which combine biofabrication and tissue engineering techniques\, try to overcome this gap by providing the cells with an environment similar to the native tissue\, recapitulating (I) the physicochemical and mechanical properties of the cellular matrix\, (II) the multicellular complexity of the different tissue compartments\, and (III) the 3D structures of the tissues. These new engineered models are key factors to improve the platforms for basic research studies\, testing new drugs or modelling diseases. Among all the engineered tissues\, the intestinal mucosa is not well represented. The intestinal mucosa is formed by the epithelium\, which is a multicellular monolayer laying on top of the lamina propria\, a connective tissue containing several cell types (mesenchymal cells\, immune cells). The gold standard intestinal models are based on epithelial cell lines derived from colon cancer cells grown on the hard porous membranes of the Transwell® inserts. The lack of the intestinal stromal compartment and the growth on a hard surface give high transepithelial electrical resistance and low apparent permeability. Therefore\, the development of better in vitro platforms\, which integrates both compartments and provides epithelium-lamina propria cell interactions\, is highly desirable. \nIn this work\, we describe an easy and cost-effective method to engineer a 3D intestinal mucosa model that combines both the epithelium and the lamina propria compartments. To build the 3D scaffolds we chose hydrogels as materials to mimic the physicochemical and mechanical properties of intestinal tissue. Thus\, hydrogel conetworks of gelatin methacryolyl (GelMA)\, a natural polymer\, and poly(ethylene glycol) diacrylate (PEGDA)\, a synthetic polymer\, are photopolymerized. On one hand\, GelMA provides biodegradation and cell adhesion sequences but it lacks long-term mechanical stability. On the other hand\, PEGDA\, is non-biodegradable and does not present cell adhesion motifs. Nevertheless\, it has good mechanical properties. By this technique\, the lamina propria compartment of the intestinal mucosa can be reproduced in vitro. To do that\, GelMA and PEGDA polymers are laden with mesenchymal cells (fibroblasts or myofibroblasts) and/or immune cells (macrophages). We demonstrated that GelMA – PEGDA hydrogel co-networks support the growth of these cells and epithelial monolayers on top of the scaffolds. Embedding fibroblasts or myofibroblasts on the hydrogel conetworks enhance the formation and the maturity of the Caco-2 epithelial monolayers\, providing barrier properties similar to in vivo. The presence of the stromal cells also enhances the recovery of the epithelial integrity when the epithelium is temporally damaged. Finally\, an immunocompetent model is obtained by the encapsulation of macrophages in the constructs. The presence of macrophages does not influence the formation of the epithelium. However\, when the epithelial monolayer is disrupted\, the presence of mesenchymal and immune cells in the stromal compartment increases cytokine secretion in a synergistic manner. Our model can successfully mimic the interactions between stromal and epithelial compartments found in vivo intestinal tissue\, offering a potential platform to be used to study absorption and toxicity of drugs\, as well as cell behaviour under physiological and pathological conditions. \nLocation: The defense will be online. People are invited to attend upon receiving a link that you have to request to vd.fisica.recerca@ub.edu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-anna-vila-giraut/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T110000
DTEND;TZID=Europe/Madrid:20201204T130000
DTSTAMP:20260406T021809
CREATED:20201202T085923Z
LAST-MODIFIED:20201202T092538Z
UID:80148-1607079600-1607086800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Javier Rodriguez Benítez
DESCRIPTION:Characterization and interpretation of cardiovascular and cardiorespiratory dynamics in cardiomyopathy patients\nJavier Rodriguez Benítez\, member of Biomedical Signal Processing and Interpretation (BIOSPIN) Group  \nFriday 4th December 2020\, at 11.00 am \nThis defense will be transmitted online at Google meet\, using this link \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-javier-rodriguez-benitez/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T110000
DTEND;TZID=Europe/Madrid:20201204T130000
DTSTAMP:20260406T021809
CREATED:20201201T133153Z
LAST-MODIFIED:20201202T090027Z
UID:80134-1607079600-1607086800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Arnau Biosca
DESCRIPTION:Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale\nArnau Biosca\, Nanomalaria Group \nThis thesis defense will take place ONLINE on the 4th December at 11.00 using the “BB Collaborate” streaming platform.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-arnau-biosca/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T100000
DTEND;TZID=Europe/Madrid:20201204T120000
DTSTAMP:20260406T021809
CREATED:20201116T153209Z
LAST-MODIFIED:20201127T110248Z
UID:79750-1607076000-1607083200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Paul Verschure
DESCRIPTION:The volitional brain in action: counterfactual error and the virtualization of memory\n \nVolitional motor control can be seen as the result of a gradual replacement of feedback by feedforward control. We have addressed this question from the perspective of an integrated architecture called the Distributed Adaptive Control (DAC) theory of mind and brain. DAC proposes that the brain is a multi-layer control system which optimizes the how of action by considering why (motivation)\, what (objects)\, where (space)\, when (time) and who (agents) or the H5W problem. We have shown that for DAC to realize optimal solutions in foraging problems\, its decision-making renders policies that simultaneously optimize perceptual evidence\, memory bias\, goals\, and utility. This raises the question of what the principles are that underlie the processing and adaptation of these factors. In this presentation\, I will focus on a link between volition\, policy adaptation and perceptual learning we have recently advanced. The dominant model of anticipatory motor control relies on the notion of an inverse model that by learning from encountered errors acquires corrective responses that supersede feedback control. However\, these models are predicated on a Markovian world assumption and thus by necessity face problems in handling exceptions\, such as observed in probe trials\, where fast feedback control is required. We solve this challenge by proposing that adaptive motor control can also be obtained by relying on a cascade of purely sensory predictions that drive feedback control via counterfactual errors or Hierarchical Sensory Predictive Control. Using robot experiments\, we have demonstrated the robustness of this solution. I will present further supporting evidence for the relevance of counterfactual error in the physiology of motor learning\, the neurophysiology of human memory as obtained with intracranial recordings and in the rehabilitation of stroke patients.  In conclusion Paul will comment on the challenges involved in bringing science to society. \n\nPaul Verschure is Catalan Institute of Advanced Studies (ICREA) Research Professor\, Director of the Synthetic Perceptive\, Emotive and Cognitive Systems Laboratory at the Institute for Bioengineering of Catalunya and the Barcelona Institute of Science and Technology. Paul has received his MA and Ph.D. in Psychology\, and has worked in Neuroscience\, Cognitive Science\, Robotics and Artificial Intelligence and his scientific aim is to develop a unified theory of mind and brain\, to validate it using synthetic methods and to apply it to quality of life enhancing technologies. To achieve the latter goal\, Paul is founder/CEO of Eodyne Systems S.L. (Eodyne.com)\, which is commercializing novel science grounded neurorehabilitation\, education and cultural heritage technologies. Paul is founder/Chairman of the Future Memory Foundation (futurememoryfoundation.org) which aims at supporting the development of new tools and paradigms for the conservation\, presentation\, and education of the history of Nazi crimes. Paul is founder/Chairman of the Convergent Science Network Foundation which hosts the annual Living Machines conference for which Paul also hosts the Convergent Science Network podcast. Paul chairs the annual Barcelona Cognition\, Brain and Technology summer school. Paul manages a multidisciplinary team of about 30 researchers with whom he has published over 400 articles in leading journals and conferences in a range of disciplines and has completed 15 Ironman races. \nThis seminar will take place online at the GoToMeeting platform \nKnow more about Paul Verschure’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-paul-verschure/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201125T000000
DTEND;TZID=Europe/Madrid:20201125T140000
DTSTAMP:20260406T021809
CREATED:20201120T124114Z
LAST-MODIFIED:20201120T124114Z
UID:79834-1606262400-1606312800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Jesús Ordoño
DESCRIPTION:Lactate: unraveling the regenerative potential for cardiac tissue engineering\nJesús Ordoño\, Biometerials for regenerative therapies grouop \nThis thesis defense will take place on the 25th November at 12.00 at Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)\, Campus Diagonal Sud. It is possible to attend to this defense but it will also be transmitted online at Google meet (meet.google.com/ufd-vtgp-gmd). \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-jesus-ordono/
LOCATION:Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)\, Carrer de Pau Gargallo\, Barcelona\, 08028\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201124T090000
DTEND;TZID=Europe/Madrid:20201125T182000
DTSTAMP:20260406T021809
CREATED:20200921T110920Z
LAST-MODIFIED:20201102T104539Z
UID:77355-1606208400-1606328400@ibecbarcelona.eu
SUMMARY:Bioengineering and MedTtech against cancer
DESCRIPTION:Bioengineering & MedTtech against cancer\n \n\n  \nTo meet the challenges in healthcare of the 21st century\, it is important to combined bioengineering and MedTech to develop biological system analyze and treatment to treat specifically cancer cells and protect the rest of the patient’s body by limiting side effects. To accomplish this\, we need to promote an innovation model where scientists\, engineers and doctors works together. \nIt’s in this optic that the digital oncology short course will take place the 24th and 25th of November 2020. This short course is part of ToHealth program\, an EIT Health activity. The course is organized by Medicen Paris and the Institute for Bioengineering of Catalonia (IBEC)\, with the collaboration of Biocat\, “la Caixa” Foundation and Meditecnologia\, under the framework of B·Debate. \nA 2 days workshop reviewing different bioengineering and medtech technologies (liquid biopsies\, targeted drug delivery\, tumor on chip\, mechanobiology and Car-T therapies…) which can significantly contribute to meet the challenges that the increasing prevalence of cancer poses on society and healthcare systems and what would be the difficulties that must be solved before these technologies are a reality in daily clinical practice. And also\, a transversal session to discuss barriers and opportunities for the translation of these technologies to the clinical practice. \n\nLocation: Online Event \n\nWe invite you to register at https://event.meetmaps.com/bioengineeringandmedtech/en/landing \n 
URL:https://ibecbarcelona.eu/event/bioengineering-and-medttech-against-cancer/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201113T100000
DTEND;TZID=Europe/Madrid:20201113T120000
DTSTAMP:20260406T021809
CREATED:20201030T121221Z
LAST-MODIFIED:20201110T121400Z
UID:78766-1605261600-1605268800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Xavier Trepat
DESCRIPTION:Mechanobiology of intestinal organoids\n \nXavier Trepat\, IBEC \nIntestinal organoids capture essential features of the intestinal epithelium such as folding of the crypt\, spatial compartmentalization of different cell types\, and cellular movements from crypt to villus-like domains. Each of these processes and their coordination in time and space requires patterned physical forces that are currently unknown. In this study\, we map the three-dimensional cell-ECM and cell-cell forces in mouse intestinal organoids grown on soft hydrogels. We show that these organoids exhibit a non-monotonic stress distribution that defines mechanical and functional compartments. The stem cell compartment pushes the ECM and folds through apical constriction\, whereas the transit amplifying zone pulls the ECM and elongates through basal constriction. Tension measurements establish that the transit amplifying zone isolates mechanically the stem cell compartment and the villus-like domain. A 3D vertex model shows that the shape and force distribution of the crypt can be largely explained by cell surface tensions following the measured apical and basal actomyosin density. Finally\, we show that cells are pulled out of the crypt along a gradient of increasing tension\, rather than pushed by a compressive stress downstream of mitotic pressure as previously assumed. Our study unveils how patterned forces enable folding and collective migration in the intestinal crypt. \nThis seminar will take place online at the Microsoft Teams Platform \nKnow more about Xavier Trepat’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-xavier-trepat/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201109T150000
DTEND;TZID=Europe/Madrid:20201109T170000
DTSTAMP:20260406T021809
CREATED:20201104T112844Z
LAST-MODIFIED:20201104T112844Z
UID:78888-1604934000-1604941200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Dolores Blanco
DESCRIPTION:Noninvasive multimodal analysis of thoracic bioimpedance and myographic signals for the assessment of chronic obstructive pulmonary disease\nDolores Blanco\, Biomedical Signal Processing and Interpretation \nChronic respiratory diseases cause morbidity and premature mortality in adult population. In particular\, chronic obstructive pulmonary disease (COPD) represents a socioeconomic burden worldwide. COPD is usually evaluated by a spirometry test to quantify the airflow limitation. Classical spirometry requires the patients to move to the medical centers making difficult the continuous monitoring. Alternatively\, other noninvasive methods have been studied to monitor respiration because of their capability to provide valuable respiratory-related information. These techniques would lighten the intrusiveness of the measurements and ease the ambulatory monitoring of respiration. However\, the applicability of these methods into the clinics is still limited because of the lack of evidence in these applications. \nThe objective of this thesis is to propose and evaluate novel noninvasive methods to monitor respiration and assess obstructive diseases. We proposed a setup and a protocol to evaluate the applicability of thoracic bioimpedance and surface myographic signals for respiration assessment in healthy subjects and COPD patients. We acquired bioimpedance\, airflow and surface myographic signals in ten healthy subjects and fifty COPD patients. The physiological data was measured during an inspiratory threshold loading protocol to evaluate the methods during restrictive conditions. The thesis consisted of three different studies published in high impact factor journals. The two first studies delved into the changes of thoracic bioimpedance during restrictive breathing and\, the third one focused on the combination of bioimpedance and myographic signals for the assessment of COPD. \nPrevious studies showed a linear relationship between thoracic bioimpedance and respiratory volume during normal breathing. Firstly\, we assessed this linear relationship in healthy subjects for the first time\, during a loading protocol. We found a strong correlation between the signals even during highest loads. Nevertheless\, bioimpedance measurement is the combination of the different impedances of body tissues\, organs and fluids and consequently\, not only volume contributes to its measurement. Accordingly\, our second study aimed to evaluate the relevance of volume and chest movement to bioimpedance measurement at different levels of inspiratory muscle activity. We characterized bioimpedance using chest movement and volume signals by linear models and neural networks for different muscle effort. The results agreed with our previous results\, indicating that respiratory volume was the main contribution to bioimpedance\, but chest movement contributed substantially and more notably at high muscle activity. Both studies provided better knowledge of thoracic bioimpedance measurements which reinforces its use for noninvasive respiratory monitoring. \nFinally\, we evaluated the combination of thoracic bioimpedance and surface myographic signals in the COPD population. We proposed two novel ratios derived from the bioimpedance amplitude and myographic activity. These ratios showed significant differences between the mild and severe COPD patients meaning that the severest patients had lower inspiratory ventilation contribution of the inspiratory muscles. Consequently\, we suggest these novel ratios to provide valuable information to noninvasively monitor and complement the classical assessment of COPD. \nThe multimodal approach proposed in this thesis supports the application of thoracic bioimpedance for respiratory monitoring during normal and restrictive breathing. Furthermore\, the combination of bioimpedance and myographic information exhibited differences between COPD severity. The proposed methods will provide additional information about COPD condition which will be easily tracked by a single wearable device. Consequently\, the results of this thesis open up the way for a high-quality noninvasive monitoring of chronic respiratory patients. \n\nThis thesis defense will take place on Monday\, 9th November\, at 15:00 hours. \nLocation: The defense will be online using Microsoft Teams. People are invited to attend upon receiving a link that you have to request to Dolores Blanco (dblanco@ibecbarcelona.eu) or Raimon Jané (rjane@ibecbarcelona.eu).
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-dolores-blanco/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20201031
DTEND;VALUE=DATE:20201108
DTSTAMP:20260406T021809
CREATED:20201015T093105Z
LAST-MODIFIED:20201015T093105Z
UID:78227-1604102400-1604793599@ibecbarcelona.eu
SUMMARY:3rd EIT Health Innovation Day
DESCRIPTION:EIT Health Innovation Day\n \nIBEC is participating\, once more\, in the organization of this year’s EIT Health Innovation Day that will be held on-line from 31st October to 7th November 2020 (Dedication per day: 30-45 min. aprox. (flexible schedule)). \nInnovation Days (i-Days) promote health innovation among university students through dozens of one-to-two-day programmes held at academic institutions around Europe. Students receive an introduction to practical health innovation tools and compete in multidisciplinary teams to tackle real-life health challenges posed by EIT Health projects\, local organisations and private corporations. \ni-Day Barcelona will invite inspirational speakers and experts within the field of health innovation. Participants will form multidisciplinary teams to develop real and viable innovations\, compete for i-Day prizes and learn practical skills in innovation. The team with the most sparkling solution will participate in the European Winners event. At the Winners event\, participants will meet fellow EIT Health Innovation Day winners from universities across Europe\, and will further develop their ideas with the support from experienced business developers. \n\nThe i-Day is open to undergraduate and postgraduate students. \nWe invite you to  register here. Registrations will be open until October 26th. \nThe best projects of the day will be candidates for 4 prizes. \nYou can also see the calendar of i-Day events.
URL:https://ibecbarcelona.eu/event/3rd-eit-health-innovation-day/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201027T091500
DTEND;TZID=Europe/Madrid:20201028T173000
DTSTAMP:20260406T021809
CREATED:20200729T101538Z
LAST-MODIFIED:20200922T073710Z
UID:76552-1603790100-1603906200@ibecbarcelona.eu
SUMMARY:13th IBEC Symposium - Bioengineering for Future and Precision Medicine
DESCRIPTION:Registration is now open for the 13th IBEC Symposium on Bioengineering for Future and Precision Medicine\n \nThe 13th IBEC Symposium will focus on one of our three main areas of application of research at IBEC: Future and Precision Medicine. Although we would have loved to meet everyone in person\, due to the COVID-19 outbreak and the uncertainty that we are living\, this edition of the IBEC Symposium will be celebrated online. We hope that this will bring IBEC other opportunities such as increasing the participation of people from other institutions and the visibility of the research being done at IBEC. So\, please help us spread the word! \nWe will use an online platform where all the talks will be streamed and posters will be available. To adapt to the online format\, the Symposium will be divided into two days. \nAll the scientific community is invited to participate. Attendees from IBEC and abroad are welcome to present their research in a poster format. Moreover\, some of these contributions will be selected by the scientific committee for an oral flash presentation. \nAdditionally\, attendees are invited to present their research in a short video (max 90-second long and horizontal) to be uploaded to the IBEC YouTube channel. The most popular video will win a prize. \n\nImportant deadlines:\nAbstract submission: 15/09/2020\nNotification of acceptance: 06/10/2020\nRegistration deadline: 26/10/2020 \n\nWe invite to register and\, if you wish\, to submit an abstract at\nhttp://events.ibecbarcelona.eu/symposium2020\n\nUseful information: \nPosters: Posters will be displayed in the online platform\, where attendees will be able to interact with the authors. Format as usual\, A0 using this template. \nFlash presentations: Will be recorded the week before the event by media professionals. \nVideo: Deadline to send a short video for the competition: 12th October 2020.
URL:https://ibecbarcelona.eu/event/13th-ibec-symposium-bioengineering-for-future-and-precision-medicine/
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201002T100000
DTEND;TZID=Europe/Madrid:20201002T120000
DTSTAMP:20260406T021809
CREATED:20200917T092229Z
LAST-MODIFIED:20200922T141340Z
UID:77332-1601632800-1601640000@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Complementary Skills Session: #LancetGate and its broader implications for the pandemic response and science dissemination 
DESCRIPTION:#LancetGate and its broader implications for the pandemic response and science dissemination\nCarlos Chaccour\, ISGlobal\, Hospital Clínic\, Universitat de Barcelona \nOn May 22\, 2020\, the Lancet published an influential report on the use of hydroxychloroquine in COVID conducted using a vast database owned by a company based in Chicago: Surgisphere. The world counted more than 300.000 deaths due to the Pandemic at that time. The paper had an immediate impact on more than 131 clinical trials with this molecule ongoing worldwide at the moment\, including the WHO-led SOLIDARITY trial which put its hydroxychloroquine arm on hold due to safety concerns. The main issue\, of course\, is that the data was fraudulent. Hydroxychloroquine would finally be discarded as a potential treatment after failing randomized clinical trials. But the broader impact of the surgisphere “database” exceeded hydroxychloroquine and shaped the pandemic response in several latinamerican countries. In this talk we will review the story of what is now known as the #LancetGate scandal. \n\nCarlos Chaccour a results-oriented global health researcher that finds joy in looking at challenges from different angles. He is interested in the whole spectrum of problem solving\, from discovery to scale-up and believes that open-minded multidisciplinary teams are key to innovation. Carlos thinks that scientists should be well versed on the complexities of policy\, funding and implementation if they are to come up with sustainable solutions. He currently focuses on malaria but enjoys the full spectrum of global health.
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-complementary-skills-session-lancetgate-and-its-broader-implications-for-the-pandemic-response-and-science-dissemination/
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200929T090000
DTEND;TZID=Europe/Madrid:20201001T174500
DTSTAMP:20260406T021809
CREATED:20200928T111739Z
LAST-MODIFIED:20200928T174115Z
UID:77582-1601370000-1601574300@ibecbarcelona.eu
SUMMARY:Imaginenano Online 2020
DESCRIPTION:Imaginenano2020 Online\n \nImaginenano2020 organisers have been closely monitoring global developments of the COVID-19 virus since the start of the year. The health and safety of our speakers\, exhibitors\, participants and staff being our number one priority\, we decided to postpone the in-person event to 2021 but organise a 3 days online event (Imaginenano2020 Online) merging 3 conferences (nanoSpain / 3PM / graphIn). \nThis international online conference will present the most recent advances in fundamental research & technology developments in Nanoscience and Nanotechnology (N&N). 40 high profile talks from worldwide most influential academia/industry experts in the N&N sector will present speeches in this international event on how advanced materials will change the future of technology and impact positively our daily life in sectors such as Energy\, Electronics or Biohealth. \nIBEC researchers Giuseppe Battaglia\, Josep Samitier and Javier Ramón Azcón and Teresa Sanchís from Strategic Initiatives will participate on Thursday\, October 01st. \n\nLocation: The event will take place via ZOOM. \nYou can find the program here. \nMore info here.
URL:https://ibecbarcelona.eu/event/imaginenano-online-2020/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200921T110000
DTEND;TZID=Europe/Madrid:20200921T130000
DTSTAMP:20260406T021809
CREATED:20200915T072231Z
LAST-MODIFIED:20200917T100832Z
UID:77259-1600686000-1600693200@ibecbarcelona.eu
SUMMARY:PhD Thesis defense: Martina Maier
DESCRIPTION:The principles of advanced virtual reality-based neurorehabilitation\nMartina Maier\, SPECS group \nHow the training in virtual reality and based on principles can support the recovery and diagnosis of disabilities after stroke. \n\nThis thesis defense will take place on Monday\, September 21st\, at 11:00 hours. \nLocation: The defense will be online. People are invited to attend upon receiving a link provided by UPF shortly before the defense.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-martina-maier/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200915T160000
DTEND;TZID=Europe/Madrid:20200915T180000
DTSTAMP:20260406T021809
CREATED:20200915T074014Z
LAST-MODIFIED:20200915T074137Z
UID:77260-1600185600-1600192800@ibecbarcelona.eu
SUMMARY:Cell Migration Virtual Seminars: Xavier Trepat
DESCRIPTION:Mechanobiology of epithelial folding and migration in intestinal organoids\nXavier Trepat\, Integrative cell and tissue dynamics group \nMore information here \nRegistration here
URL:https://ibecbarcelona.eu/event/cell-migration-virtual-seminars-xavier-trepat/
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200909T100000
DTEND;TZID=Europe/Madrid:20200909T230000
DTSTAMP:20260406T021809
CREATED:20200915T075316Z
LAST-MODIFIED:20200915T075343Z
UID:77263-1599645600-1599692400@ibecbarcelona.eu
SUMMARY:InsideScientific: Javier Burgués
DESCRIPTION:Decoding Turbulent Chemical Plumes with Improved Signal Processing and Machine Learning\nJavier Burgués\, Signal and information processing for sensing systems group \nMillions of years of evolution has aided animals and insects to develop the highly sensitive ability to track and navigate odor plumes over great distances.  This behavior is integral to their survival and propagation of the species; decades of research has gone into finding a way to replicate this inate behaviour in autonomous mobile robots.  And while it is accepted that animals are able to find hidden information from complex signals for odor navigation purposes\, the sub-Hz bandwidth of chemical sensors largely limits the efficacy of information retrieval.  Naturally\, this hinders the application of mobile robots for chemical source localization tasks. \nDuring this webinar sponsored by Aurora Scientific\, Dr. Burgués will discuss how he and his team are leveraging various signal processing and machine learning techniques in order to decode the fine-scale structure of turbulent chemical plumes using low-cost chemical sensors.  Specifically\, he will discuss three signal processing methods they developed to improve MOX sensor dynamics\, and share the experimental setups they used to test their theories. Finally\, he will share data from recent experiments and elaborate on the conclusions of their studies and how robotic plume tracking technology might apply to industrial and air quality monitoring\, research and more. \n\nYou can watch the seminar here
URL:https://ibecbarcelona.eu/event/insidescientific-javier-burgues/
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200716T110000
DTEND;TZID=Europe/Madrid:20200716T130000
DTSTAMP:20260406T021809
CREATED:20200706T063623Z
LAST-MODIFIED:20200707T090653Z
UID:75980-1594897200-1594904400@ibecbarcelona.eu
SUMMARY:PhD Thesis defense: Helena Lozano
DESCRIPTION:Electrical and topographical study of bacterial appendages at the nanoscale\nHelena Lozano\, Nanoscale bioelectrical characterization group \nSome bacteria can exchange electrons with non-soluble electron acceptors\, such as minerals. This phenomenon is called Extracellular Electron Transfer (EET) and it can be done through several mechanisms\, especially through conductive bacterial nanowires. \nThe main objective of this thesis is the investigation of the polarization properties of electrochemically active bacteria and their appendages. Specifically\, I have studied two types of bacteria\, Shewanella oneidensis MR-1 and cable bacteria. I have used the Electrostatic Force Microscopy (EFM)\, which measures the electrostatic force using a nanometric probe\, combined with finite element simulations to obtain the polarization properties. The electrostatic force depends mainly on the geometry and dielectric constant of the probe-sample system. \nFirst\, I have developed a way to obtain the dimensions of objects avoiding physical contact with the sample by measuring the electrostatic force. I have tested this technique on silver nanowires and bacterial flagella\, optimizing the EFM technique to nanowire-like biological samples at the nanoscale. Afterward\, I have studied S. oneidensis Outer Membrane Extensions (OMEs)\, responsible for the EET. I have obtained a low value of the dielectric constant (εOME=3.7±0.7). However\, considering that the conduction mechanism of such OMEs is through electron hopping\, where electrons are localized\, these results do not contradict the literature. \nI have also studied the cable bacteria\, especially the fibers that are along this filamentous bacterium. The dielectric constant of the fibers was εr=7±1. This result is not compatible with the conductivity reported in the literature. Therefore\, a core-shell model was proposed with a conductive core of h~10–20nm. \nSubsequently\, I have performed qualitative EFM measurements in liquid over living and rehydrated S. oneidensis bacteria. \nFinally\, I have performed macroscale measurements in living S. oneidensis using a microfluidic device that I designed\, fabricated and characterized at the Denmark Technical University (DTU)\, Copenhagen. It was used to perform two-electrode impedance measurements. \n\nIn order to attend to the defense\, you must send an email to the president of the Doctoral Commission of the Faculty of Physics (Dr. Eugeni Grauges Pous – vd.fisica.recerca@ub.edu) with a minimum notice of 48 hours and will be held via Microsoft Teams.
URL:https://ibecbarcelona.eu/event/75980/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200703T100000
DTEND;TZID=Europe/Madrid:20200703T120000
DTSTAMP:20260406T021809
CREATED:20200605T081640Z
LAST-MODIFIED:20200605T081640Z
UID:74896-1593770400-1593777600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Santiago Marco
DESCRIPTION:Signal and Data Processing Workflows for Untargeted Chemical Analysis: Sensor Array and Mass Spectrometry Analysis of Complex Gas Samples\nSantiago Marco \, IBEC \nIn diverse sectors such as health\, food\, environment\, complex natural gas samples are analysed. Those samples can contain hundreds or thousands of compounds. In many cases\, the question to be answered does not require full separation\, quantification\, and identification of all compounds. Instead detection of abnormal samples (normal/ faulty)\, assignation of classes to samples (e.g.healthy/disease)\, or evaluation of global quantitative indexes (e.g odour intensity) is required. \nThe analysis of gas phase samples can be carried out with high-end lab equipment based on Chromatography-Mass Spectrometry or lower cost systems based on chemical sensors. In all cases\, the resulting raw signals/data need substantial efforts to extract the hidden information. In health applications the problem of biomarker discovery becomes like finding a needle in a haystack. Intimate knowledge of the instrumental problems and the sampling conditions is key for the correct interpretation of the results. \nThese problems are often addressed by building mega-variate predictive models using tools from machine learning. However\, in small sample conditions the possibilities to obtain overoptimistic results abound due to the curse of dimensionality. Careful model validation and statement of model validity domains is needed. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Santiago Marco’s research here \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-santiago-marco/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200626T100000
DTEND;TZID=Europe/Madrid:20200626T120000
DTSTAMP:20260406T021809
CREATED:20200605T081203Z
LAST-MODIFIED:20200618T100739Z
UID:74893-1593165600-1593172800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Pere Roca-Cusachs
DESCRIPTION:Sensing the matrix: transducing mechanical signals from integrins to the nucleus\n \nPere Roca-Cusachs \, IBEC \nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\, are strongly determined by the properties of the extracellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. \nI will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to transcriptional regulation. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Pere Roca-Cusachs’ research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-pere-roca-cusachs/
LOCATION:IBEC
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200605T100000
DTEND;TZID=Europe/Madrid:20200605T120000
DTSTAMP:20260406T021809
CREATED:20200504T102718Z
LAST-MODIFIED:20200602T070514Z
UID:73835-1591351200-1591358400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Benedetta Bolognesi
DESCRIPTION:Deep mutagenesis to understand Protein Phase Transitions\n \nBenedetta Bolognesi \, IBEC \nSpecific insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. Whether the protein aggregates themselves or other forms of the proteins are toxic to cells is still unclear in many of these diseases. This lack of understanding of the causes of cellular toxicity is reflected in the general failure of multiple therapeutic approaches so far attempted. The causes of this rely mainly on the lack of systematic approaches able to estimate in parallel the effect of mutations on cell viability as well as on protein conformation. Our lab uses deep mutagenesis as a systematic and unbiased approach to identify and investigate the toxic species of proteins. \nIn this seminar I will explain how we used this approach to report on the toxicity of thousands of protein sequences and how\, more recently\, we adapted this method to track more specific biochemical processes\, such as amyloid nucleation. Overall\, the results I will discuss demonstrate that deep mutagenesis is a powerful approach to study intrinsically disordered proteins and also illustrate that it can be used to genetically validate assays as discovery platforms. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Benedetta Bolognesi’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-benedetta-bolognesi/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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