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DTSTART;TZID=Europe/Madrid:20240314T090000
DTEND;TZID=Europe/Madrid:20240314T170000
DTSTAMP:20260403T235952
CREATED:20240312T151616Z
LAST-MODIFIED:20240313T155224Z
UID:115981-1710406800-1710435600@ibecbarcelona.eu
SUMMARY:ICMS-IBEC Symposium
DESCRIPTION:Dear all\, \n  \nIt is our pleasure to invite you to the ICMS-IBEC symposium on 14 March from 13.00 – 17.00 (Ceres 0.31\, coffee starts at 12.45). Colleagues from both IBEC and ICMS will pitch their research domains with the intent to get better acquainted with each other’s science. We have fostered a successful collaboration for more than 4 years and we hope that this event will stimulate additional bottom-up connections between researchers from both organizations. \nYou can find the full programme here. \nYou can join the symposium online (no need to register)\, by using this link. \n 
URL:https://ibecbarcelona.eu/event/breaking-boundaries-in-science-icms-annual-symposium-2024/
LOCATION:Online
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240322T120000
DTEND;TZID=Europe/Madrid:20240322T130000
DTSTAMP:20260403T235952
CREATED:20240319T141525Z
LAST-MODIFIED:20240319T141525Z
UID:116181-1711108800-1711112400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Engineering enzymes for biomedical and biotechnological applications\nEmilio Parisini\, Latvian Institute of Organic Synthesis (Riga\, Latvia)\, University of Bologna (Italy) \nEnzyme engineering has the potential to improve the activity\, the stability and the substrate recognition of enzymes. As such\, it paves the way for the design of novel enzymes with improved performances for a wide range of applications. This rational approach can accelerate the production and the use of biocatalysts in different biotechnological sectors\, thus in turn allowing the improvement of chemical processes through the application of green chemistry concepts.  In this talk\, two examples from our current research will be discussed: \nFructosyl Peptide Oxidases (FPOX) are deglycating enzymes that find application as key enzymatic components in diabetes monitoring devices. Indeed\, their use with blood samples can provide a measurement of the concentration of glycated hemoglobin and glycated albumin\, two well-known diabetes markers. However\, the FPOX currently employed in enzymatic assays cannot directly detect whole glycated proteins\, making it necessary to perform a preliminary proteolytic treatment of the target protein to generate small glycated peptides that can act as viable substrates for the enzyme. This is a costly and time consuming step. The rapidly growing demand for cheap\, efficient and rapid diabetes monitoring tests could be met by developing enzymatic assays for glycated hemoglobin and albumin that do not require a preliminary digestion of the proteins. In our lab\, we used an in silico protein engineering approach to enhance the overall thermal stability of the enzyme and widen it active site to improve its catalytic activity toward large substrates. \nThe fast and uncontrolled accumulation of plastic waste in the environment has long begun to impact on the natural ecosystems and to pose an existential threat to all forms of life on our planet. Advanced technical solutions to the plastic waste management problem are therefore in urgent demand. To this end\, enzymatic approaches to plastic degradation hold great promises as novel and more efficient enzymes are constantly being developed. Leaf-branch Compost Cutinase (LCC)\, a naturally occurring PETase\, has been reported to outperform all other known PET-degrading enzymes and to present a melting temperature (Tm) of 84.7°C. This enzyme has been noticeably engineered in 2020\, leading to the so-called ICCG variant (Tm = 94.0°C)\, the current gold standard. In our lab\, we engineered a LCC that features significantly enhanced PETase activity and thermal stability relative to the gold standard ICCG.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisini/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240405T100000
DTEND;TZID=Europe/Madrid:20240405T110000
DTSTAMP:20260403T235952
CREATED:20240307T114216Z
LAST-MODIFIED:20240326T130314Z
UID:115873-1712311200-1712314800@ibecbarcelona.eu
SUMMARY:PhD discussions: Gülsun Bagci and Joana Admella
DESCRIPTION:Cell-Derived Extracellular Matrices for 3D in vitro Tumor Models\nGülsun Bagci\, Biomaterials for Regenerative Therapies Group \nDecellularized Extracellular matrices are new scaffolds for bioengineering of 3D tumor-ECM in vitro models. The tunable composition\, properties\, and structure of Cell-derived Matrices (CDMs) make them versatile and easy to use by using desired cell types. Moreover\, deposition of ECM can be achieved by adding specific stimulants such as Macromolecular crowding (MMC) like Ficoll/dextran sulfate or treating with hypoxia/starvation. Our aim is to fabricate CDM by two strategies as 2D culture CDMs from human dermal fibroblasts (hDFs)  or 3D culture CDM from bone marrow human mesenchymal stem cells (BM-hMSCs)/Human Adipose-derived stem cells (hAMSCs) in the presence of MMC/Ascorbic acid/ TGFβ-1  on Poly Lactic acid (PLA) derived microparticles (MPs) to generate 3D and 2D culture CDMs\, which can be used as scaffold for reseeding cancer cells or used as bioinks to generate tumor models for cancer research and for testing anti-cancer drugs. \nIn this study\, we generated 2D culture CDM from hDFs and 3D culture CDMs of BM-hMSCs and hAMSCs. To prepare 2D CDMs\, hDF were treated with Ascorbic acid (AA) or Ficoll\, AA\, TGFβ-1 combination for 2-weeks to increase the deposition of CDM. To fabricate 3D culture CDM\, cells were cultured into PLA MPs. MPs were produced by jet break-up method\, and their size distribution was calculated by ImageJ whereas their porosity was imaged under SEM. Moreover\, MPs were functionalized with fibronectin to enhance the cell adhesion. hMSCs/hAMSCs were seeded on MPs in a spinner flask for 8 hours. Then\, cell-seeded MPs were cultured for 2 weeks to produce CDM. The cellular viability and cell seeding in the MPs were evaluated. The ECM production before and after decellularization was evaluated by BCA\, hydroxyproline\, SEM\, qRT-PCR\, and immunofluorescence. Values were normalized by the total DNA. Microtissues and cells on 2D culture were also decellularized with 50mM NH4OH\, 0.05% TritonX-100 solution and characterized. \nBased on our results\, for hDF cells; Ficoll\, TGFβ-1 and Ascorbic acid combination\, and also ascorbic acid alone treatments increased total protein and total collagen production. For BM-hMSCs\, total collagen and protein after 2-weeks incubation was increased significantly in the presence of Ascorbic acid condition on the fibronectin coated MPs. AA increased total protein and total collagen production for hAMSCs at 3D culture. \nCDMs are promising and tunable biomaterials to establish 3D in vitro tumor models for cancer research. This platform possess a powerful potential for testing anti-cancer drugs  for personalized medicine in the coming years. \n\nExploring the potential of Galleria mellonella for the study of bacterial infections\nJoana Admella\, Bacterial Infections: Antimicrobial Therapies Group \nBacterial infections are becoming more threatening every day. Pathogens such as Pseudomonas aeruginosa\, Staphylococcus aureus\, Mycobacterium abscessus\, or Burkholderia cenocepacia pose significant challenges due to antimicrobial resistance. Our group has extensive experience in studying pathogenic microorganisms\, with a focus on understanding bacterial virulence and biofilm formation. \nThe insect Galleria mellonella is an alternative animal model widely used for studying bacterial infections and evaluating the toxicity of various molecules and materials. It presents a wide range of advantages\, including low cost\, easy maintenance\, and lack of ethical constraints. Furthermore\, very precise doses can be injected\, facilitating the testing of diverse treatments like antibiotics\, nanomedicines\, or even bacteriophages. Notably\, their innate immune system closely resembles that of mammals\, encompassing both cellular and humoral defenses. These features make Galleria mellonella a very valuable model for investigating host-pathogen interactions\, infection dissemination\, and immune response. Here\, we present an overview of this animal model\, showing a variety of methodologies and applications that have enhanced our understanding of bacterial infections and expanded our knowledge of this insect.
URL:https://ibecbarcelona.eu/event/phd-discussions-gulsun-bagci-and-joana-admella/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240412T100000
DTEND;TZID=Europe/Madrid:20240412T110000
DTSTAMP:20260403T235952
CREATED:20240229T104756Z
LAST-MODIFIED:20240229T104756Z
UID:115723-1712916000-1712919600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Kevin Braeckmans
DESCRIPTION:Delivering effector molecules in cells in vitro and ex vivo by photoporation.\nKevin Braeckmans\, Biophotonics Research Group\, Lab. General Biochemistry and Physical Pharmacy\, Ghent University\, Belgium \nDelivery of bioactive compounds\, such as proteins and nucleic acids\, into cells in vitro or ex vivo is a generic requirement for many applications in the life sciences\, such as for the engineering of therapeutic cells. Physical delivery methods are attractive in this context as they are well-controlled\, and can accommodate a broad variety of effector molecules and cell types. Photoporation is such a recently developed physical delivery technology which combines laser stimulation with photothermal nanoparticles. Localized thermal effects upon laser irradiation can create pores in the cell membrane\, allowing the influx of external molecules in cells. Importantly\, photoporation is very gentle to cells\, resulting in excellent cell viability and preservation of a cell’s phenotype and functionality. In this presentation I will give an overview of the most notable work that we performed on photoporation as a next-generation transfection technology in the past decade. \n\nKevin Braeckmans first studied physics before doing his doctoral studies in pharmaceutical sciences at Ghent University in Belgium. From early on he was passionate about developing biophotonics technologies for drug delivery and diagnostics. In 2008 he was appointed professor at Ghent University as the group leader of the Bio-Photonics Research Group. In 2015 he received a prestigious ERC Consolidator Grant and became full professor in 2018. His research presently focuses on studying biological barriers to nanomedicines by advanced microscopy techniques\, and combining light with nanoparticles to enable light-triggered drug delivery and related therapeutic applications. He is a co-author of >250 publications\, Clarivate Highly Cited Author in 2022 and 2023\, and co-inventor of 17 patent applications. Presently he is a co-founder and CSO/CTO of the spin-off company Trince.
URL:https://ibecbarcelona.eu/event/ibec-seminar-kevin-braeckmans/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240412T150000
DTEND;TZID=Europe/Madrid:20240412T170000
DTSTAMP:20260403T235952
CREATED:20240212T115203Z
LAST-MODIFIED:20240212T115203Z
UID:115460-1712934000-1712941200@ibecbarcelona.eu
SUMMARY:BMBC meeting
DESCRIPTION:Please mark your calendars! The next BMBC meeting will be held on Friday 12th of April 2024\, from 3-6pm at PRBB\, Marie Curie Room. \n  \nFor this edition we will have an external speaker\, Michael Healy from Queensland University\, Australia. Michael is a postdoc in the group of Brett Collins\, and he has recently published the structure of the whole Commander complex\, involved in endosomal recycling to the plasma membrane (Healy et al.\, Cell\, 2023). We’re sure his talk will be highly interesting for the whole community and we strongly count on your participation. \nWe further thank Albert Pol who invited Michael and Oriol Gallego who is hosting him at PRBB for the help in coordinating Michael’s talk with our BMBC event. \n\n \nHere is a preliminary program \n\n15h – 15h45 Michael Healy (Brett Collins group\, Queensland University) \nUnravelling the Molecular Architecture of the Commander Complex.  \n15h45 – 16h15 Jessica Angulo-Capel (Felix Campelo lab\, ICFO) \nSpatiotemporal Dynamics of Protein Export at the Golgi Apparatus Resolved by Single Particle Tracking \n16h15-16h45     —–    Coffee Break    —— \n16h45-17h15 Albert Herms (Albert Pol group\, IDIBAPS-UB) \nEpithelioids: Self-sustaining 3D epithelial cultures to study long-term cellular processes \n17h15-17h45 Laura Ferigle (Raúl Estévez group\, IDIBELL-UB) \nInsights into MLC pathophysiology by biochemical and structural studies \n  \nMore details will follow soon. Feel free to visit our website and advertise it to your colleague\, they can read the program there and subscribe to the googlegroup. \nBMBC | bmbc (felixcampelo.wixsite.com) \n \n \nLooking forward to see many of you there!
URL:https://ibecbarcelona.eu/event/bmbc-meeting/
LOCATION:PRBB (Parc de Recerca Biomèdica de Barcelona)\, Marie Curie Room (PRBB inner square)
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240415T180000
DTEND;TZID=Europe/Madrid:20240415T190000
DTSTAMP:20260403T235952
CREATED:20240404T084618Z
LAST-MODIFIED:20240408T155030Z
UID:116553-1713204000-1713207600@ibecbarcelona.eu
SUMMARY:La ricerca Italiana a Barcellona
DESCRIPTION:“La ricerca italiana a Barcellona – Nuovi metodi per comprendere le malattie neurodegenerative.” \nThe Consulate General of Italy will present Dr. Benedetta Bolognesi with the “Cavaliere dell’ordine della Stella” medal in recognition of her career. \nIn addition\, Dr Benedetta Bolognesi\, Group Leader of Protein Phase Transitions in Health and Disease\n\, Prof. Josep Samitier\, Director of IBEC and Prof. Giuseppe Battaglia\, group leader of Molecular Bionics group will discuss Italian research: new methods to fight neurodegenerative diseases. \nThis event will be mainly in Italian. \nInformation here.
URL:https://ibecbarcelona.eu/event/la-ricerca-italiana-a-barcellona/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240419T163000
DTEND;TZID=Europe/Madrid:20240419T183000
DTSTAMP:20260403T235952
CREATED:20240409T161611Z
LAST-MODIFIED:20240409T161611Z
UID:116842-1713544200-1713551400@ibecbarcelona.eu
SUMMARY:HeLa et al.
DESCRIPTION:HeLa et al.\n\n\n\n\nA video essay by TESS MARSCHNER\n\n\n\n\nBarcelona\, 2024\, 12:00 min (ENG) Technical Support: Julio César Palacio\n\n\n\n\nInaugural event: \nFriday\, April 19th at 4:30PM\nParc Científic de Barcelona · Carrer Baldiri Reixac\, 4-8\, Dolors Aleu room \n\n\n\n\n“HeLa et al.” is the result of the creative process carried out by visual artist Tess Marschner during her artistic residency at the Institute of Bioengineering of Catalonia (IBEC). \nIn her predominantly videographic and research-based works\, she delves into the impact of scientific and theoretical knowledge on social dynamics. Her exploration focuses on feminist subjects\, non-human entities and animal actors. \nThe video essay titled “HeLa et al.” serves as a contemplation on female and reproductive (parts of) bodies within techno-sciences: Henrietta Lacks’ immortal cell line\, the cloned sheep Dolly\, wombs\, eggs and mice show up both as technical components of the scientific realm as well as entities that challenge the notion of the human\, raising ethical considerations. \n“HeLa et al.” was developed during her Artistic Residency at IBEC 2023/24. \n\n\n\n\nEVENT AGENDA: 4:30PM-6:30PM\n\n\n\n\nWelcome by Teresa Sanchis · Head of Strategy at IBEC.\nIntroduction by Tess Marschner\, Artist in Residence at IBEC.\nVideo Screening.\nPanel discussion & Q&A.\nVideo Screening.\nToast and final words by Josep Samitier\, Director of IBEC.\n\nRegister here.
URL:https://ibecbarcelona.eu/event/hela-et-al/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240424T090000
DTEND;TZID=Europe/Madrid:20240426T150000
DTSTAMP:20260403T235952
CREATED:20240116T095022Z
LAST-MODIFIED:20240116T095022Z
UID:114152-1713949200-1714143600@ibecbarcelona.eu
SUMMARY:3rd edition EMBL-IBEC Conference ENGINEERING MULTICELLULAR SYSTEMS
DESCRIPTION:3rd edition EMBL – IBEC Conference\n\n\n\n\nENGINEERING MULTICELLULAR SYSTEMS\n\n\n\n\nEMBL and IBEC aim to contribute to the discussion on challenges and opportunities in the expanding field of engineered multicellular systems. \nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos. \nThis biennial series will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \n#EMBL_IBECConf \nEMBL-IBEC Conference – ENGINEERING MULTICELLULAR SYSTEMS (ibecbarcelona.eu)
URL:https://ibecbarcelona.eu/event/3rd-edition-embl-ibec-conference-engineering-multicellular-systems/
LOCATION:Barcelona Biomedical Research Park (PRBB)\, Dr. Aiguader 88 \, Barcelona\, 08003
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240503T100000
DTEND;TZID=Europe/Madrid:20240503T110000
DTSTAMP:20260403T235952
CREATED:20240429T130247Z
LAST-MODIFIED:20240430T135545Z
UID:117333-1714730400-1714734000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ovijit Chaudhuri
DESCRIPTION:Cell migration and morphogenesis in viscoelastic matrices\nOvijit Chaudhuri\, University of Standford \nThe extracellular matrix (ECM) is a complex assembly of structural proteins that provides physical support and biochemical signaling to cells in tissues. Over the last two decades\, studies have revealed the important role that ECM elasticity plays in regulating a variety of biological processes in cells\, including stem cell differentiation and cancer progression. However\, tissues and ECM are often viscoelastic\, displaying stress relaxation over time in response to a deformation\, and viscoplastic\, exhibiting irreversible deformations in response to mechanical stress.  In this talk\, I will discuss our recent findings on how matrix viscoelasticity regulates various biological processes\, including collective invasion by cancer cells\, morphogenesis of pluripotent stem cells\, and monocyte migration.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ovijit-chaudhuri/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240507T124500
DTEND;TZID=Europe/Madrid:20240507T133000
DTSTAMP:20260403T235952
CREATED:20240409T125915Z
LAST-MODIFIED:20240415T140034Z
UID:116840-1715085900-1715088600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurora Hernandez-Machado
DESCRIPTION:Biomicrofluidic analysis of hematological diseases by means of mathematical biomechanical models and statistical analysis: Cells and hydrogels in microchannels and microrheometers\nAurora Hernandez-Machado\, Departament de Fisica de la Materia Condensada\, Universitat de Barcelona \nWe have developed microfluidic devices for precise characterization of hematological diseases. By means of one drop of blood and mathematical models based on biomechanics\, we analyze the properties of cells and microrheological properties such as the viscosity of blood. We will present a microrheometer to determine in a fast\, chip and sensitive way the viscosity of a drop of blood. Experimental results of malaria infected red blood cells in microchannels with endothelial slits and hydrogels with organ-on-a-chip will be discussed. Sprouting is a fundamental cellular behavior that plays an essential role in vascular development and angiogenesis. Due to its relevance to many aspects of human health\, the ability to accurately reproduce cell sprouting is of broad and multidisciplinary interest. We will present microfluidic experiments and compare with theoretical models in which endothelial cells chemotactically migrate into a fibrin-based porous hydrogel which mimics the extracellular matrix. By means of statistical analysis we improve the diagnosis of the hematological diseases. We predict if a sample of blood corresponds to healthy blood or to blood with a hematological disease. We have obtained different performance for the different methods\, some of them with very good results and an accuracy of 94%.
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurora-hernandez-machado/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240508T103000
DTEND;TZID=Europe/Madrid:20240508T130000
DTSTAMP:20260403T235952
CREATED:20240411T100514Z
LAST-MODIFIED:20240411T100738Z
UID:116912-1715164200-1715173200@ibecbarcelona.eu
SUMMARY:Research4talent
DESCRIPTION:On Wednesday 8th May 2024 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n\n\n\n\nThe event offers you the opportunity to engage with our researchers and inquire about their day-to-day work in the lab\, career trajectories\, work-life balance\, mobility\, etc. \nIn 2023\, IBEC signed more than 130 internship agreements for undergraduate and master’s students with a wide range of national and international universities. \nIf you are interested in IBEC’s tenth edition of reSEARCH4TALENT\, please register. \n  \n\n\n\n\n\n\n\n\nPROGRAMME · 8th May 2024 \n\n\n\n\n\n\n\n10:45\nWelcome\n\n\n11:00\nDeputy talent and training director talk. Elisabeth Engel\, “What is IBEC?”\n\n\n11:20\nHuman Resources presentation\n\n\n11:30\nPhD Committee presentation\n\n\n\n-Coffee break-\n\n\n11:45\nCareers Fair*: a chance for participants to mingle and chat with our researchers.\n\n\n13:00\nLabs visits\n\n\n\n\n\n\n\n* To know in advance in which of our research lines you are interested in the Careers Fair\, you can find the full research groups here. \nRegister here.
URL:https://ibecbarcelona.eu/event/research4talent-6/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240509T120000
DTEND;TZID=Europe/Madrid:20240509T130000
DTSTAMP:20260403T235952
CREATED:20240426T080635Z
LAST-MODIFIED:20240429T132435Z
UID:117301-1715256000-1715259600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolò Accanto
DESCRIPTION:2P-BRAINSCOPY: pushing the boundaries of two-photon microscopy to study large neuronal networks in behaving mice.\nNicolò Accanto\, Inserm researcher at the in Insitut de la Vision (IDV)\, in the group of Valentina Emiliani\, Paris  \nIn the past 15 years\, the synergy of two-photon (2P) microscopy and optogenetics has transformed neuroscience\, enabling high-resolution imaging and precise photostimulation of neuronal activity. Today\, understanding how neuronal networks in the brain interact to generate perception\, memory and behaviour\, or in other words\, deciphering the neuronal code\, requires to push the limits of 2P microscopy. \nThis involves studying the brain of freely moving animals engaged in natural tasks and accessing thousands of neurons on a very fast (100 ms) timescale\, across large (> 5 mm) brain regions\, while keeping individual neuron (5 µm) spatial resolutions. \n  \nIn this presentation I will outline our recent endeavours towards these goals. I will first show how 2P holographic photostimulation based on spatial light modulators is capable to precisely target individual neurons within a large volume [1]. I will then describe how we can use minimally invasive GRIN lenses to access deeper brain regions [2]\, below the scattering limit. Finally\, I will detail our most advanced technique: a novel fiber-based miniaturized microscope to image and photostimulate neuronal activity in freely moving mice [3\,4]. In the last part of the talk\, I will present future directions for further developments and applications in neuroscience. \n  \nReferences \n[1] Accanto\, N. et al. Multiplexed temporally focused light shaping for high-resolution multi-cell targeting. Optica 5\, 1478 (2018). \n[2] Accanto\, N. et al. Multiplexed temporally focused light shaping through a gradient index lens for precise in-depth optogenetic photostimulation. Sci. Rep. 9\, 7603 (2019). \n[3] Accanto\, N. et al. A flexible two-photon fiberscope for fast activity imaging and precise optogenetic photostimulation of neurons in freely moving mice. Neuron 111\, 176-189.e6 (2023). \n[4] Lorca-Cámara\, Antonio\, Blot\, Francois & Accanto\, N. Recent advances in light patterned optogenetic photostimulation in freely moving mice. Neurophotonics In press\, 11\, S11508 (2024).
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolo-accanto/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240514T150000
DTEND;TZID=Europe/Madrid:20240514T170000
DTSTAMP:20260403T235952
CREATED:20240509T120306Z
LAST-MODIFIED:20240509T120306Z
UID:117486-1715698800-1715706000@ibecbarcelona.eu
SUMMARY:Seminar “The Canadian health research following COVID-19 pandemic – artificial intelligence (AI)\, generative systems\, quantum computing and beyond"
DESCRIPTION:We are glad to invite you to this seminar organized by IBEC where Marek W. Radomski\, Vice-Dean Research College of Medicine\, University of Saskatchewan\, Saskatoon\, Canada will talk about the Canadian health research following COVID-19 pandemic\, the next Tuesday 14th of May at 15h at the Faculty of Medicine Clinic (UB). \nMarek W. Radomski\,\nVice-Dean of Investigation College of Medicine\, University of Saskatchwan\, Saskatoon\, Canada and President of The Association of Faculties of Medicine of Canada\, Vice-Deans Research Committee.   \nHe has developed his research career in Poland\, the United Kingdom and Ireland (both in a pharmaceutical company and at Trinity College in Dublin)\, at the University of Houston and in Canada (in two universities) \nThe Canadian health research following COVID-19 pandemic – artificial intelligence (AI)\, generative systems\, quantum computing and beyond. \nThe COVID-19 pandemic claimed millions of lives worldwide and greatly disrupted societal fabric across the globe. \nDespite amazing achievements of vaccine research and development many areas of health research have been adversely affected by limitations caused by pandemic. \nHowever\, AI\, generative systems and quantum computing are examples of a postpandemic research acceleration with substantial health research and service potentials. \nThe presentation will focus on these challenges and opportunities through the lens of the College of Medicine University of Saskatchewan and of the Association of Faculties of Medicine of Canada. \n  \n\n\n\n  \n\n\n\n\n14/05/2024 · 15h\n\n\n\nAula Manuel Corachan  (5th floor) · UB Faculty of Medicine Clinic (Carrer de Casanova\, 143\, Eixample\, 08036 Barcelona)\n\n\n\nIBEC\n\n\n\nNo registration needed
URL:https://ibecbarcelona.eu/event/seminar-the-canadian-health-research-following-covid-19-pandemic-artificial-intelligence-ai-generative-systems-quantum-computing-and-beyond/
LOCATION:Aula Manuel Corachan  (5th floor) · UB Faculty of Medicine Clinic (Carrer de Casanova\, 143\, Eixample\, 08036 Barcelona)
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240517T100000
DTEND;TZID=Europe/Madrid:20240517T110000
DTSTAMP:20260403T235952
CREATED:20240408T072307Z
LAST-MODIFIED:20240410T115407Z
UID:116794-1715940000-1715943600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Erika Ferrari
DESCRIPTION:Beating Organs-on-Chip: leveraging on motion to mimic human organ physiological/diseased states in vitro\nErika Ferrari\, Commercial Science Leader\, BiomimX Srl \nBeating Organs-on-Chip are in vitro miniaturized models developed within the uBeat® platform\, which integrates microfluidics\, 3D human cell culture and controlled mechanical stimulation to recapitulate\,\nwith unprecedented precision and predictability\, clinically relevant models reflective of human pathophysiology and complex diseases. Every tissue in the body is subject motion and this motion can be mimicked within the uBeat® platformplatforms\, which provides 3D microtissues with controlled mechanical stimulation (e.g.\, stretching or compression) resulting in more reliable\, responsive\, and predictive in vitro model models to investigate new therapies. BiomimX lead model is uHeart Visone\, Tox Sciences\, 2023; +4 additional cardiac publications )\, a functional beating heart on a chip for cardiotoxicity and safety testing. uHeart was recently qualified with 12 drugs as a predictor of functional cardiotoxicity\, showing 83.3% sensitivity\, 100% specificity\, a nd 91.6% accuracy. BiomimX pipeline consists of predictive physiological and pathological models\, engineered solely through mechanical stimulation\, without the need for introducing exogenous compounds (e.g.\, cytokines) into the cell culture chamber. uKnee the first in vitro model of human osteoarthritis; Occhetta\, Nature Biomed Eng\, 2019 ) has successfully supported a recent IND application. Other key models include uScar cardiac fibrosis; Visone\, Adv Healthcare Mat\, 202 2023)\, uGut a barrier model of the intestinal epithelium & endothelium; Ballerini\, Nature Biomed Eng\, under review )\, uLung and uLiver Heart a multiorgan platform used to study the off-target cardiotoxicity of liver-metabolized drugs; Ferrari\, Adv Mat Tech\, 2023 ).
URL:https://ibecbarcelona.eu/event/ibec-seminar-erika-ferrari/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240520T090000
DTEND;TZID=Europe/Madrid:20240520T140000
DTSTAMP:20260403T235952
CREATED:20240510T113302Z
LAST-MODIFIED:20240510T114103Z
UID:117526-1716195600-1716213600@ibecbarcelona.eu
SUMMARY:IBEC – KAIST Symposium
DESCRIPTION:Delegations of the Institute for Bioengineering of Catalonia (IBEC\, Spain) and Korean Advanced Institute of Science and Technology (KAIST\, Korea) will introduce some of their exciting research at the IBEC – KAIST Mini Symposium with presenters from the field of materials science\, polymer chemistry\, tissue engineering\, self-assembly\, chemical biology and synthetic biology. \nDate: May 20th 2024 \nVenue: Sala Baoba\, Tower I\, Floor 11\, Baldiri I Reixac 4 – 12\, Barcelona. \nSchedule: \n9:30 César Rodriguez-Emmenegger\, IBEC\nWelcome \n9:50 Hee-Seung Lee\, KAIST \n10:10 Javier Ramon-Azcon\, IBEC\nOrgans-on-chip with integrated optical sensors: advanced models for evaluation of potential therapies \n10:30Myungeun Seo\, KAIST\nPolymerization/depolymerization-induced self-assembly/disassembly \n10:50 César Rodriguez-Emmenegger\, IBEC\nUsing Nature’s engineering principles to design biointerfaces and synthetic cells \n11:10  Break \n11:30 Sang Woo Han\, KAIST\nPlasmonic hybrid nanoarchitectures for boosting light-to-chemical energy conversion \n11:50 Nina Kostina\, IBEC\nHow spontaneous curvature induces the morphogenesis of dendrimersome vesicles? \n12:10 Dong Ki Yoon\, KAIST\nEvaporation-induced self-assembly of biopolymers and its application \n12:30 Mohit Kumar\, IBEC / UB\nActive Vesicles: Nanocontainers for temporally regulated cargo delivery \n12:50 Byeong-Su Kim\, Yonsei University\nRecent advances in the design and biological applications of functional polyethers \n13:10 Ramona Santini\, IBEC\nDiscotic amphiphile supramolecular polymers for drug release and cell activation with light \n13:30 Adriano Caliari\, Jonas Quandt\, Jenny Englert\, IBEC/DWI\nFlash talks \n14:00 César Rodriguez-Emmenegger\, IBEC\nClosing remarks
URL:https://ibecbarcelona.eu/event/117526/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240521T080000
DTEND;TZID=Europe/Madrid:20240522T170000
DTSTAMP:20260403T235952
CREATED:20240314T164406Z
LAST-MODIFIED:20240314T164638Z
UID:116006-1716278400-1716397200@ibecbarcelona.eu
SUMMARY:THE BARCELONA BLOOD-BRAIN-BARRIER (B4) SYMPOSIUM
DESCRIPTION:To fulfil the promise of applying bioengineering to improve the lives of patients\, we need to adopt a holistic approach encompassing understanding of biological/pathological mechanisms\, development of engineered systems\, and consideration of clinical needs. Hence\, the B4 symposium\, by bringing together experts studying the BBB from a biological\, engineering and medical perspective\, will greatly aid IBEC in its goal of developing bioengineering solutions to deliver therapies against brain disorders. \nBarcelona is home to numerous research groups pushing forward the knowledge frontier of the blood-brain barrier (BBB) and its role in brain disorders. To foment interaction across this community\, we are organizing the Barcelona Blood-Brain-Barrier (B4) symposium to bring the BBB-community of Barcelona together to discuss advances in the field. The event will focus on the mechanisms underlying BBB physiology (e.g.\, brain endothelial specialization\, neurovascular coupling\, molecular transport)\, its role in brain disorders (neurodegeneration\, infectious diseases\, cancer)\, and nano/bioengineering strategies to deliver therapies across the BBB. \nThe first edition of this symposium will take place on May 21st-22nd\, 2024. As our inaugural keynote speaker\, we have the honour to welcome Prof. Martin Lauritzen (Copenhagen University). Prof. Lauritzen has been instrumental in our understanding of regulation of cerebral blood-flow by the neurovascular unit\, nanoparticle transport dynamics across the BBB\, and in developing in vivo imaging systems to study the brain vasculature. \n\n\n\nCheck que program and register here.
URL:https://ibecbarcelona.eu/event/the-barcelona-blood-brain-barrier-b4-symposium/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240524T100000
DTEND;TZID=Europe/Madrid:20240524T110000
DTSTAMP:20260403T235952
CREATED:20240507T151701Z
LAST-MODIFIED:20240513T084437Z
UID:117479-1716544800-1716548400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Sergi Garcia-Manyes
DESCRIPTION:Single molecule insights into cellular mechanotransduction\nSergi Garcia-Manyes\, Single Molecule Mechanobiology laboratory\, The Francis Crick Institute and King’s College London \n  \nCellular mechanostransduction relies on the conversion of mechanical cues into chemical signals\, which propagate from the focal adhesion hub through the cytoskeleton to ultimately reach the nucleus through the Nuclear Pore Complex (NPC)\, and switch on specific force-dependent transcriptional programmes. However\, how cellular mechanotransduction is regulated by the nanomechanical properties of the underpinning force-bearing proteins remains largely unknown. Here we first used a newly developed single-molecule magnetic tweezers combined with UV-light to demonstrate that oxidation of a previously cryptic methionine in the talin mechanosensor impairs vinculin binding. When translating the single-molecule findings into the cellular context\, we found a loss in talin/vinculin co-localisation at focal adhesions of NIH3T3 mouse fibroblasts when exposed to µM concentrations of H2O2 and a decrease in the nuclear localisation of the YAP transcription factor (TF). In this vein\, how the nuclear shuttling of mechanosensitive TFs is regulated by their mechanical properties remains also unclear.  By using a combination of single-molecule mechanics and single-cell optogenetics\, we discovered that proteins with locally soft regions in the vicinity of the nuclear-localization sequence exhibit higher nuclear-import rates. Inspired by these findings\, we designed a short and easy-to-express unstructured peptide tag that accelerates the nuclear-import rate of stiff protein cargos. Altogether\, our cross-scale experiments provide a single molecule perspective onto cellular mechanotransduction. \n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-sergi-garcia-manyes/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240531T093000
DTEND;TZID=Europe/Madrid:20240531T123000
DTSTAMP:20260403T235952
CREATED:20240418T152608Z
LAST-MODIFIED:20240507T142311Z
UID:117195-1717147800-1717158600@ibecbarcelona.eu
SUMMARY:MSCA Doctoral Networks: convocatoria 2024
DESCRIPTION:Event in Spanish \nEl objetivo de las Doctoral Networks es implementar programas de doctorado mediante asociaciones de organizaciones de diferentes sectores de Europa y más allá para formar doctorandos y doctorandas altamente cualificados\, estimular su creatividad\, mejorar sus capacidades de innovación y potenciar su empleabilidad a largo plazo. Gracias al componente de movilidad (internacional\, interdisciplinar e intersectorial) y al enfoque orientado a la innovación\, se proporcionan perspectivas profesionales optimizadas en los sectores académico y no académico. \nLa convocatoria de Redes de Doctorado 2024 tendrá un presupuesto de 608\,6 M€ y abrirá el 29 de mayo de 2024 (fecha límite: 27 de noviembre de 2024). \nEstá previsto que se puedan agendar reuniones con el NCP para resolver dudas concretas entre las 14 y las 16h (a confirmar). \n  \nAgenda preliminar \n09.30 h   Bienvenida. \n09.40 h  La convocatoria MSCA-DN 2024 y novedades. Puntos importantes por la preparación de propuestas. Xavier Ronald Eekhout\, NCP MSCA\, FECYT. \n11.30 h    Pausa de café. \n11.50 h    Caso de éxito. Prof Gabriel Gomila\, IBEC Group Leader \n12.20 h    Experiencia en la gestión de una MSCA-DN. Rosa Miralles\, IBEC Projects Office. \nInscripciones aquí. \n  \nAyuda GPE2022-001085 financiada por MCIN/AEI/ 10.13039/501100011033 \n 
URL:https://ibecbarcelona.eu/event/msca-doctoral-networks-convocatoria-2024/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240531T100000
DTEND;TZID=Europe/Madrid:20240531T120000
DTSTAMP:20260403T235952
CREATED:20240517T085223Z
LAST-MODIFIED:20240517T085303Z
UID:117772-1717149600-1717156800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Wenting Zhao
DESCRIPTION:Engineering the Nanoscale Membrane Topography in Cells\nWenting Zhao\, School of Chemistry\, Chemical Engineering and Biotechnology\, Nanyang Technological University\, Singapore and Institute for Digital Molecular Analytics and Science (IDMxS)\, Singapore  \nAbstract. \nCell membranes serve as a central platform to host a variety of proteins essential for cellular activities such as cell signaling\, morphogenesis\, and membrane trafficking. At the same time\, the membranes also undergo drastic morphological changes in a number of essential processes\, such as endocytosis\, intracellular trafficking\, and cytokinesis\, etc. An intriguing yet challenging question to answer is whether and how the shapes of the membrane impact the dynamics of membrane proteins or the periphery proteins interacting with the membrane. However\, membrane shape changes often happen at sub-micro to the nanoscale\, which is approaching the limit of conventional microscopy imaging resolution and difficult to examine quantitatively. In this work\, we will introduce our efforts in employing vertically aligned nanostructures to generate defined membrane topography in live cells and in vitro. We will discuss our findings on the membrane curvature-guided accumulation of membrane proteins\, including oncogenic Ras proteins and viral proteins\, as well as the membrane-associated protein condensation. In addition to plasma membrane\, we also explore the nanoscale topography guidance on nuclear membrane and its implication in differentiating malignant cancer cells. We envision more new insights would be revealed by bridging advanced nanotechnology to nanoscale dynamics at cell surfaces. \n\nShort Bio \nDr. Wenting Zhao is currently an assistant professor in the School of Chemistry\, Chemical Engineering\, and Biotechnology at Nanyang Technological University\, Singapore. She received her Ph.D. degree in Bioengineering at the Hong Kong University of Science and Technology\, and completed her postdoc training at Stanford University. Her research group aims to reveal the nanoscale interplay between membrane morphology and protein assembly using advance nanofabrication and nanomaterials. Specific focuses of her studies are on the nanoscale topography-guided protein clustering and complex assembly\, and their impacts on disease progression\, such as cancer progression\, viral replication\, and immune activation. \nGroup website: www.wtzhaolab.com.
URL:https://ibecbarcelona.eu/event/ibec-seminar-wenting-zhao/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240603T080000
DTEND;TZID=Europe/Madrid:20240605T170000
DTSTAMP:20260403T235952
CREATED:20240314T164809Z
LAST-MODIFIED:20240314T164809Z
UID:116012-1717401600-1717606800@ibecbarcelona.eu
SUMMARY:Nanomotors International Conference
DESCRIPTION:The Nanomotors International Conference: 20th Anniversary will be held June 2-5\, 2024 in Barcelona. This event will gather high-profile plenary and invited speakers and world-class researchers specializing in nanomotors to celebrate the 20th anniversary of the first publications in the field. \n\n\nFrom the early days of artificial catalytic nanomotors\, the expanding field of active matter has moved into new and exciting areas spanning physical length-scales\, academic disciplines\, and international boundaries. \n\n\nThis conference will feature invited talks\, breakout sessions\, and posters exploring leading-edge designs and applications of nanomotors. This year’s meeting will focus on biomedical applications and collective behaviour of self-propelled nanomotors\, from both experimental and theoretical perspectives. \n\n\nNanomotors International will foster collaborations; highlight the positive impact of these technologies on society; promote scientific advances and innovative applications; and explore current and future challenges to bringing these technologies to the clinic and to the market. \nCheck the program and register here.
URL:https://ibecbarcelona.eu/event/nanomotors-international-conference/
LOCATION:CosmoCaixa
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240605T160000
DTEND;TZID=Europe/Madrid:20240605T170000
DTSTAMP:20260403T235952
CREATED:20240522T090926Z
LAST-MODIFIED:20240527T134609Z
UID:117890-1717603200-1717606800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Irene Lázaro
DESCRIPTION:Enhanced regeneration through in vivo cell reprogramming: lessons from the first decade of research and a success story in the mouse heart\nIrene de Lázaro\, PhD1\,2\,3 \n1 Department of Biomedical Engineering\, NYU Tandon School of Engineering\, New York University \n2 Cardiovascular Research Center\, NYU School of Medicine and NYU Langone Health \n3 Harvard John A Paulson School of Engineering and Applied Sciences\, Harvard University \n  \nOur lab designs and deploys bioengineering strategies – including gene therapies and nanomedicines – to reprogram cell identity\, differentiation and/or cellular responses in living organisms with the ultimate goal of helping tissues regenerate better. In this seminar\, I will share the lessons learned after the first decade of in vivo cellular reprogramming research. Moreover\, I will present our most recent data that demonstrates that on and off expression of stemness-related transcription factors induces partial reprogramming of cardiac myocytes to a rejuvenated state. In an age-dependent mouse model of heart failure\, reprogramming the biological age of cardiac myocytes to a youthful state resulted in significant improvement of cardiac function. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-irene-lazaro/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240607T093000
DTEND;TZID=Europe/Madrid:20240607T133000
DTSTAMP:20260403T235952
CREATED:20240515T155124Z
LAST-MODIFIED:20240515T155124Z
UID:117700-1717752600-1717767000@ibecbarcelona.eu
SUMMARY:Encuentro De Las Plataformas Isciii De Apoyo A La I+D+I En Biomedicina Y Ciencias De La Salud
DESCRIPTION:El Instituto de Bioingeniería de Cataluña acoge la Jornada Informativa de las Plataformas ISCIII de Apoyo a la I+D+i en Biomedicina y Ciencias de la Salud\, organizada por la Plataforma ISCIII de Biomodelos y Biobancos (P_ISCIII_BB)\, la Plataforma ISCIII de Dinamización e Innovación de las Capacidades Industriales del SNS y su Transferencia Efectiva al Sector Productivo (ITEMAS)\, y la Plataforma ISCIII de Soporte para la Investigación Clínica (SCReN)\, en adelante denominadas “Plataformas ISCIII”\, junto con Nanomed Spain. \nLas Plataformas del Instituto de Salud Carlos III (ISCIII) de apoyo a la I+D+i en Biomedicina y Ciencias de la Salud constituyen un conjunto de infraestructuras y profesionales\, pertenecientes a diversas instituciones\, quienes ofrecen servicios transversales para respaldar el sistema de I+D+i. Su objetivo es facilitar la generación y transferencia de conocimiento de alta calidad dentro del Sistema Nacional de Salud. \nLa sesión incluirá ponencias que abordarán la misión y visión de las tres Plataformas ISCIII\, así como el papel de estas en el contexto internacional. Entre los temas a tratar en la Jornada Informativa se encuentran\, entre otros\, la convergencia de las tres plataformas bajo la coordinación del ISCIII\, la transferencia del conocimiento científico a la industria y la sociedad\, y el desarrollo de ensayos clínicos \n 
URL:https://ibecbarcelona.eu/event/encuentro-de-las-plataformas-isciii-de-apoyo-a-la-idi-en-biomedicina-y-ciencias-de-la-salud/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240612T100000
DTEND;TZID=Europe/Madrid:20240612T113000
DTSTAMP:20260403T235952
CREATED:20240422T080133Z
LAST-MODIFIED:20240513T092457Z
UID:117198-1718186400-1718191800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jan Lammerding
DESCRIPTION:Nuclear mechanobiology – from striated muscle disease to ultrarapid cellular mechanosensing\nJan Lammerding\, PhD\, Weill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering\, Cornell University\, Ithaca\, NY\, USA \nAbstract. The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is investigating how physical forces acting on the nucleus can challenge the integrity of the nucleus\, alter its structure\, and cause genomic\, transcriptomic\, and other functional changes. In this seminar\, I will discuss our findings that highlight the importance of the nuclear envelope proteins lamins A/C in mediating nuclear stability and mechanotransduction in mechanically stressed cells and tissues\, and how lamin mutations result in reduced nuclear stability and increased nuclear damage in striated muscle cells\, which may explain the muscle-specific defects in many diseases caused by lamin mutations (laminopathies). Our data demonstrate that reducing cytoskeletal forces on the fragile lamin A/C mutant nuclei by disrupting the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex is sufficient to reduce nuclear damage in striated muscle tissue and to improve cardiac function and survival in multiple mouse models of lamin A/C related striated muscle disease. Furthermore\, by combining cyclic strain application with precision nuclear run-on sequencing (PRO-seq)\, a novel transcriptome sequencing technique that\, unlike traditional RNA sequencing\, enriches for nascent RNA transcripts and simultaneously provides a base-pair resolution map of active RNA polymerases\, and Omni-ATAC\, an improved chromatin accessibility assay\, we recently established an experimental pipeline to detect rapid\, genome-wide changes in chromatin organization and transcription in response to cyclic mechanical strain. Our studies indicate that cyclic strain application results in the transcription of numerous mechanoresponsive genes within less than 2 minutes\, which is faster than the expected time for typical mechanoresponsive cytoplasmic signaling pathways to reach the nucleus\, and that the mechanoresponsive genes are already poised for gene transcription. These findings point to an exciting\, previously unrecognized role of the nucleus in regulating the activation of mechanoresponsive genes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jan-lammerding/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240619T093000
DTEND;TZID=Europe/Madrid:20240619T133000
DTSTAMP:20260403T235952
CREATED:20240610T071939Z
LAST-MODIFIED:20240610T071939Z
UID:118270-1718789400-1718803800@ibecbarcelona.eu
SUMMARY:Open Science (Spanish)
DESCRIPTION:CIENCIA ABIERTA Y PROPIEDAD INTELECTUAL \nOpen science and intellectual property (IP) regulation share the same fundamental objective of promoting innovation for social\, scientific and economic development. However\, there may be some tension due to the fact that IP rights can be used as a basis for controlling and managing the way in which protected subject matter can be accessed. The results of scientific research may result in scholarly articles or original databases that can be protected by copyright or inventions that can be protected by patents and other forms of intellectual property. Many open access initiatives\, repositories or collaborative projects operate on the basis of clear licensing of intellectual property. \nThis event will be held in Spanish \n\nLa ciencia abierta y la regulación de la propiedad intelectual e industrial (PI) comparten el mismo objetivo fundamental de promover la innovación para el desarrollo social\, científico y económico. Sin embargo\, puede existir cierta tensión debido al hecho de que los derechos de PI pueden utilizarse como base para controlar y gestionar la forma en que se puede acceder a la materia protegida. Los resultados de la investigación científica pueden dar lugar a artículos académicos o a bases de datos originales que pueden protegerse mediante derechos de autor o invenciones que pueden protegerse mediante patentes y otras formas de propiedad intelectual. Muchas iniciativas\, repositorios o proyectos de colaboración de acceso abierto funcionan sobre la base de una concesión clara de licencias de propiedad intelectual. \nEl Institut de Bioenginyeria de Catalunya junto con la Universitat de Barcelona y Nanomed Spain organiza esta Jornada para exponer y debatir las complementariedades o posibles conflictos entre los dos paradigmas en el marco español\, persiguiendo una comprensión clara de su uso y aplicación en el día a día de la práctica científica. \nRegistro aquí: Ciencia Abierta y Propiedad Intelectual – NANOMED Spain
URL:https://ibecbarcelona.eu/event/open-science-spanish/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240621T080000
DTEND;TZID=Europe/Madrid:20240621T150000
DTSTAMP:20260403T235952
CREATED:20240613T080342Z
LAST-MODIFIED:20240613T080342Z
UID:118537-1718956800-1718982000@ibecbarcelona.eu
SUMMARY:Second Hand Exchange Market
DESCRIPTION:To celebrate the World Environment Day (5 June) IBEC’s Sustainability Committee is organizing a second-hand exchange market!\nYou can bring those pieces of clothing and lab materials that are clean and in good shape\, but you don’t use anymore\, and take one for free! \nSAVE THE DATE:\n📅 21st of June\n📍 in front of the Cluster II reception\n⏰ 9:00 to 15:00 \nAt the end of the day\, we will donate all the clothing left to a charity. \n❗❗We only accept clean and good-condition clothes and lab material ❗❗
URL:https://ibecbarcelona.eu/event/second-hand-exchange-market/
LOCATION:Cluster II
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240625T140000
DTEND;TZID=Europe/Madrid:20240625T170000
DTSTAMP:20260403T235952
CREATED:20240610T071836Z
LAST-MODIFIED:20240610T071836Z
UID:118413-1719324000-1719334800@ibecbarcelona.eu
SUMMARY:Seminar SparkCyto TECAN
DESCRIPTION:Multimode User Day\nAgenda:\n1. Absorbance\, Fluorescence and Luminescence\nreading modes\n1. Incubation options: gas\, temperature\, shaking\, injectors\,…\n2. Brightfield Imaging\n3. Fluorescence Imaging\n4. Hands-on session: SparkCyto \n  \nWhere? Parc Científic de Barcelona\nc/Baldiri Reixach\, 10. Torre I\, Floor 11\, Sala Baobab (IBEC)\nWhen? 25th June 2024 (Tuesday)\, 14-17h\nOrganizer: Institute for Bioengineering of Catalonia – Tecan\nTecan speaker: Nicola Vettore (application specialist)\nRegistration: https://forms.office.com/e/6mMYTESqe6
URL:https://ibecbarcelona.eu/event/seminar-sparkcyto-tecan/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240626T170000
DTEND;TZID=Europe/Madrid:20240626T183000
DTSTAMP:20260403T235952
CREATED:20240619T073137Z
LAST-MODIFIED:20240619T073137Z
UID:118704-1719421200-1719426600@ibecbarcelona.eu
SUMMARY:IMAB closure project (Catalan)
DESCRIPTION:As part of IBEC’s science education initiatives\, this year we have been running the IMAB project\, which aims to bring the latest advances in bioengineering in organ and tissue regeneration to the over-65s. The aim of the project\, beyond being a dissemination activity\, has been to gather their impressions and transmit them to the scientific community. \nWe have been holding various sessions in civic centres\, adult education centres and university extension classes… And now it is time to fulfil the last objective of the project\, to share the opinions of the population gathered over the last few months: \nDate: Tuesday 26th June\nPlace: Espai BiblioLab – Sagrada Familia Library\nLocation:C/ de Provença\, 480\, L’Eixample\, 08025 Barcelona\nTime: from 5 to 6.30 p.m. \nThis event will be held in Catalan. \nThis event will be open to all members of the public and will serve to publicise the results and opinions obtained from the population. There will be a short introduction to the project\, followed by a talk on the latest advances in organ and tissue regeneration research that was given at the sessions\, and finally\, the conclusions will be presented. \nWe hope to see you there! \n\nEn el marc de les iniciatives d’educació científica organitzades per l’IBEC\, aquest any hem desplegat el projecte IMAB\, que mira d’apropar els últims avenços de la Bioenginyeria en la regeneració d’òrgans i teixits a la població més gran de 65 anys. L’objectiu del projecte\, més enllà de fer una activitat de divulgació\, ha estat recollir les seves impressions i transmetre-les a la comunitat científica. \nHem estat realitzant diverses sessions a centres cívics\, escoles d’adults i aules d’extensió universitària… I ara toca complir amb l’últim objectiu del projecte\, compartir les opinions de la població recollides aquests darrers mesos: \nData: dimecres 26 de juny\nLloc: Espai BiblioLab – Biblioteca Sagrada Familia\nUbicació: C/ de Provença\, 480\, L’Eixample\, 08025 Barcelona\nHorari: de 17 a 18.30h \nAquest esdeveniment estarà obert a tots els públics i servirà per donar a conèixer els resultats i les opinions obtingudes de la població. Farem una petita introducció del projecte\, seguidament la xerrada sobre els últims avenços de la recerca en la regeneració d’òrgans i texitis que es feia a les sessions; i per tancar\, s’exposaran les conclusions. \nEsperem veure-us allà!
URL:https://ibecbarcelona.eu/event/imab-closure-project-catalan/
LOCATION:C/ de Provença\, 480\, L’Eixample\, 08025 Barcelona
CATEGORIES:Outreach / Fair / Festival
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240628T093000
DTEND;TZID=Europe/Madrid:20240628T170000
DTSTAMP:20260403T235952
CREATED:20240604T113538Z
LAST-MODIFIED:20240604T113538Z
UID:118272-1719567000-1719594000@ibecbarcelona.eu
SUMMARY:GREEN LAB: REDUCING THE IMPACTS OF UNIVERSITY LABORATORIES IN THE ENVIRONMENT
DESCRIPTION:Laboratories consume three to five times more energy and resources than standard office spaces\, with significant environmental impacts from constant equipment operation and disposable plastic use. \nAgainst this background\, the project ‘Sustainable Laboratories’ (NACH-LABS)\, a joint effort of the Hamburg University of Applied Sciences\, the Technical University of Darmstadt\, and IUTA e.V.\, the European School of Sustainability Science and Research (ESSSR)\, the Inter-University Sustainable Development Research Programme and the UK Consortium for Sustainability Research (UK-CSR)\, are organising the international symposium Green Labs: Reducing the Impacts of University Laboratories on the Environment. \nDue to its focus on sustainability\, the event will be held online. Therefore\, the Sustainability Committee of IBEC\, in collaboration with PCB and Nanomed Spain\, believes that organizing a satellite event to collectively follow the main event would be a great opportunity to bring together our community\, facilitating networking and sharing local experiences. \nThis event will consist of two parts. In the first part\, the official conference will be streamed. The second part will be an opportunity for local networking and experience sharing of our journey towards more sustainable research. \nWe invite you to present a 5-minute short talk on your experiences in making your labs more sustainable. You can register and send your proposals. \nRegistration here: Green Lab: Reducing the impacts of University laboratories in the environment (ibecbarcelona.eu)
URL:https://ibecbarcelona.eu/event/green-lab-reducing-the-impacts-of-university-laboratories-in-the-environment/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240705T100000
DTEND;TZID=Europe/Madrid:20240705T120000
DTSTAMP:20260403T235952
CREATED:20240618T140841Z
LAST-MODIFIED:20240618T140841Z
UID:118701-1720173600-1720180800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Shahid Uddin
DESCRIPTION:Developability assessment of biologics and formulation of novel molecules\nShahid Uddin\, PhD\, MBA\, Senior Director of Drug Product\, Formulation & Stability within the CMC department at Immunocore\, UK \nIt’s vital to ensure appropriate assessment of molecules at the early research phase is carried out to risk mitigate movement into the development phase. This ensures the best risk of success with minimal usage of resources and finances. This presentation will highlight the procedures for assessing developability and also showcases the challenges associated with administering low-concentration biologics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-shahid-uddin/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240717T150000
DTEND;TZID=Europe/Madrid:20240717T150000
DTSTAMP:20260403T235952
CREATED:20240620T104046Z
LAST-MODIFIED:20240712T061459Z
UID:118724-1721228400-1721228400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Sabina Quader
DESCRIPTION:Nanomedicine to Tackle Unmet Medical Needs in CNS Disorders\nSabina Quader\, Innovation Center of NanoMedicine (iCONM)\, Kawasaki Institute of Industrial Promotion\, Kawasaki\, Kanagawa 210-0821 Japan \nThe brain is undoubtedly the body’s most essential and intricate organ\, and brain disorders are closely tied to this intricacy. Categorized as “CNS diseases\,” a wide range of brain-related conditions – including Alzheimer’s\, dementia\, Amyotrophic Lateral Sclerosis\, stroke\, brain tumors\, and more – present daunting challenges. Regrettably\, many of these diseases currently lack adequate treatment\, underscoring the urgent need for innovative and multidimensional efforts to combat these persistent problems. In this regard\, nanomedicine shows tremendous potential for diagnosing and treating many life-threatening diseases\, including cardiovascular and genetic disorders\, CNS diseases\, and cancers1. The field of nanomedicine is constantly revolutionizing healthcare with innovative approaches to tackling severe health issues. However\, it is also crucial to actively translate these novel approaches more effectively. In our laboratory at the Innovation Center of NanoMedicine (iCONM)\, we aim to effectively bridge innovation and translation. Our nanomedicine platform is based on polymeric micelles that are constructed from poly(ethylene glycol)-b-poly(amino acids) (PEG-PAA) copolymers and have already demonstrated significant promise through their clinical translation potential2. The PEG-PAA copolymers are highly biocompatible and have the unique ability to engineer versatile\, dynamic covalent chemistry-based approaches to link the cargo with the carriers; this feature ultimately improves spatiotemporal control over drug release kinetics\, which is one of the critical properties of drug-loaded nanocarriers\, along with size and surface properties. In this presentation\, optimal design features of nanomedicine will be discussed\, focusing on treating CNS diseases\, mainly brain cancers3\,4. An overview of our Japan-Spain international collaborative research focused on drug delivery to hypothalamic neurons for tackling obesity will also be presented5. \nReferences– \n\nQuader and K. Kataoka*\, Mol Ther\, 25 (2017) 1501.\nCabral\, K. Miyata\, K. Osada\, K. Kataoka*\, Chem. Rev.\, 118 (2018) 6844.\nKinoh\, S. Quader\, H. Shibasaki\, X. Liu\, A. Maity\, T. Yamasoba\, H. Cabral*\, K. Kataoka*\,ACS Nano\, 14 (2020) 10127.\nQuader*\, X. Liu\, K. Toh\, Y.-L. Su\, A. R. Maity\, A. Tao\, W. K. D. Paraiso\, Y. Mochida\, H. Kinoh\, H. Cabral\, K. Kataoka*\, Biomaterials\, 267 (2021)120463.\nJ Garcia-Chica\, WK D Paraiso\, S Zagmutt\, A Fosch\, A Reguera\, X Ariza\, S Alzina\, L Sanchez-Garcia\, S Fukushima\, K Toh\, N Casals\, D Serra\, L Herrero\, J Garcia\, K Kataoka\, X Ariza\, S Quader*\, R Rodriguez-Rodriguez*\, Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance\,  Sci. 11 (2023) 2336-2346\n\n\nDr. Quader did her Ph.D. in Synthetic Organic Chemistry from Griffith University\, Brisbane\, Australia 2007. Following her Ph.D.\, she started working as a Research Chemist at Research Directions Pty Ltd\, Brisbane\, Australia. In 2010\, she joined Professor Kazunori Kataoka’s world-renowned biomaterial research laboratory at the Materials Engineering Department of Tokyo University with a Japanese government -funded prestigious JSPS postdoctoral fellowship. After completing two years of JSPS fellowship\, she continued her work at the same laboratory for another two years as Project Researcher. Since 2015\, she has been an integral part of the Innovation Center of NanoMedicine (iCONM)\, Kawasaki\, Japan\, as a Senior Research Scientist and\, as of 2023\, as a Deputy Principal Research Scientist. Dr. Quader’s area of expertise lies in developing stimuli-sensitive nanomaterials tailored for targeted drug delivery to address challenging diseases. Dr. Quader is currently a principal investigator in multiple projects and overseeing international research activities at iCONM as Chief Coordinator of Global Partnership. One of her international collaborative research endeavors\, “COnCorD\,” was one of the three bilateral projects awarded by the Spanish State Agency for Research (AEI) and the Japanese Medical Research Agency (AMED) as a result of an invitation for joint project proposals from early-stage researchers in Japan and Spain in the “Nanomedicine” research area.
URL:https://ibecbarcelona.eu/event/ibec-seminar-sabina-quader/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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