BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute for Bioengineering of Catalonia
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20140101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20160203T110000
DTEND;TZID=UTC:20160203T130000
DTSTAMP:20260424T150053
CREATED:20160126T113706Z
LAST-MODIFIED:20160126T113706Z
UID:95892-1454497200-1454504400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Isil Tekeli
DESCRIPTION:“Bioengineering approach to study the role of cell migration during zebrafish heart regeneration”\nIsil Tekeli\, Control of Stem Cell Potency group\nIsil will be defending her PhD thesis on Wednesday 3rd February at 11:00 in the Sala de Graus Aulari of the Physics Faculty of the UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-isil-tekeli-2/
LOCATION:Sala de Graus Aulari\, Physics Faculty\, UB\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160202T110000
DTEND;TZID=UTC:20160202T133000
DTSTAMP:20260424T150053
CREATED:20160118T141019Z
LAST-MODIFIED:20170801T130631Z
UID:21039-1454410800-1454419800@ibecbarcelona.eu
SUMMARY:Nano World Cancer Day
DESCRIPTION:Bienvenido al NANO WORLD CANCER DAY 2016!\nEl próximo 2 de febrero se celebrará la tercera edición del NANO WORLD CANCER DAY (NWCD)\, un evento de alcance mundial organizado en el marco del Día Mundial del Cáncer.\nSu principal objetivo es dar a conocer las últimas innovaciones en materia de nanomedicina contra el cáncer\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \nDurante el NANO WORLD CANCER DAY 2016 se organizarán eventos simultáneos en diferentes países de toda Europa\, con la presencia de la prensa. Este año los países participantes en el acontecimiento internacional serán: Alemania\, Austria\, Francia\, Grecia\, Irlanda\, Italia\, Países Bajos\, Portugal\, España\, Suiza\, Turquía y Reino Unido. \nDurante este día\, expertos en Nanomedicina de cada país\, y desde los diferentes campos (investigadores\, médicos\, oncólogos\, emprendedores\, etc.) expondrán los últimos adelantos y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer. \nNANO WORLD CANCER DAY es un evento que se inició en 2013 y está organizado a nivel europeo por ETP Nanomedicine (European Technology Platform)\, en el marco del proyecto europeo ENATRANS (Enabling Nanomodicine Translation)\, y de manera local por los diferentes componentes de la plataforma en cada país\, en España\, NanomedSpain. \nPROGRAMA: \n\n11:00 Josep Samitier (Coordinador de NanomedSpain. Director de el Instituto de Bioingeniería de Catalunya (IBEC))\n11:15 Pendiente confirmar\n11:30 Mª Jesús Vicent (Investigadora principal en Centro de Investigación Príncipe Felipe (CIPF))\n11:45 Mª Luisa Villahermosa (Directora de I+D en GENOMICA)\n12:00 Aleix Prat (Jefe de Oncología Médica del Hospital Clínic\n Investigador principal en Vall d’Hebron Institute of Oncology (VHIO))\n12:15 Tiempo de debate y preguntas\n\nLUGAR:\nAula Magna\nUniversitat de Barcelona\nC. Casanova 143 · 08036 Barcelona \nEnlace para registrarse:\nhttps://ibecbarcelona.eu/events/nanoworldcancerday
URL:https://ibecbarcelona.eu/event/nano-world-cancer-day/
LOCATION:Paranimf de la Facultat de Medicina\, Universitat de Barcelona\, C. Casanova 143 · 08036 Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160202T110000
DTEND;TZID=UTC:20160202T133000
DTSTAMP:20260424T150053
CREATED:20160118T141019Z
LAST-MODIFIED:20160118T141019Z
UID:95888-1454410800-1454419800@ibecbarcelona.eu
SUMMARY:Nano World Cancer Day
DESCRIPTION:Bienvenido al NANO WORLD CANCER DAY 2016!\nEl próximo 2 de febrero se celebrará la tercera edición del NANO WORLD CANCER DAY (NWCD)\, un evento de alcance mundial organizado en el marco del Día Mundial del Cáncer.\nSu principal objetivo es dar a conocer las últimas innovaciones en materia de nanomedicina contra el cáncer\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \nDurante el NANO WORLD CANCER DAY 2016 se organizarán eventos simultáneos en diferentes países de toda Europa\, con la presencia de la prensa. Este año los países participantes en el acontecimiento internacional serán: Alemania\, Austria\, Francia\, Grecia\, Irlanda\, Italia\, Países Bajos\, Portugal\, España\, Suiza\, Turquía y Reino Unido. \nDurante este día\, expertos en Nanomedicina de cada país\, y desde los diferentes campos (investigadores\, médicos\, oncólogos\, emprendedores\, etc.) expondrán los últimos adelantos y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer. \nNANO WORLD CANCER DAY es un evento que se inició en 2013 y está organizado a nivel europeo por ETP Nanomedicine (European Technology Platform)\, en el marco del proyecto europeo ENATRANS (Enabling Nanomodicine Translation)\, y de manera local por los diferentes componentes de la plataforma en cada país\, en España\, NanomedSpain. \nPROGRAMA: \n\n11:00 Josep Samitier (Coordinador de NanomedSpain. Director de el Instituto de Bioingeniería de Catalunya (IBEC))\n11:15 Pendiente confirmar\n11:30 Mª Jesús Vicent (Investigadora principal en Centro de Investigación Príncipe Felipe (CIPF))\n11:45 Mª Luisa Villahermosa (Directora de I+D en GENOMICA)\n12:00 Aleix Prat (Jefe de Oncología Médica del Hospital Clínic\n Investigador principal en Vall d’Hebron Institute of Oncology (VHIO))\n12:15 Tiempo de debate y preguntas\n\nLUGAR:\nAula Magna\nUniversitat de Barcelona\nC. Casanova 143 · 08036 Barcelona \nEnlace para registrarse:\nhttp://ibecbarcelona.eu/events/nanoworldcancerday
URL:https://ibecbarcelona.eu/event/nano-world-cancer-day-2/
LOCATION:Paranimf de la Facultat de Medicina\, Universitat de Barcelona\, C. Casanova 143 · 08036 Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160129T120000
DTEND;TZID=UTC:20160129T140000
DTSTAMP:20260424T150053
CREATED:20160128T073632Z
LAST-MODIFIED:20160128T073632Z
UID:95893-1454068800-1454076000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ariadna Bartra
DESCRIPTION:“Detecció d’estats inadequats per la conducció de un vehicle a partir de la degradació del control dinàmic”\nAriadna Bartra\, Signal and Information Group for Sensing Systems group\nAriadna will be defending her PhD thesis on Friday 29th January at 12:00 in room A44M of the Faculty of Physics at the UB. \nEverybody is welcome to attend. \n—\nIf you would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ariadna-bartra-2/
LOCATION:Room A44M\, Physics Faculty\, UB\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160129T120000
DTEND;TZID=UTC:20160129T140000
DTSTAMP:20260424T150053
CREATED:20160128T073632Z
LAST-MODIFIED:20160128T075852Z
UID:21213-1454068800-1454076000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ariadna Bartra
DESCRIPTION:“Detecció d’estats inadequats per la conducció de un vehicle a partir de la degradació del control dinàmic”\nAriadna Bartra\, Signal and Information Group for Sensing Systems group\nAriadna will be defending her PhD thesis on Friday 29th January at 12:00 in room A44M of the Faculty of Physics at the UB. \nEverybody is welcome to attend. \n—\nIf you would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ariadna-bartra/
LOCATION:Room A44M\, Physics Faculty\, UB\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160128T113000
DTEND;TZID=UTC:20160128T123000
DTSTAMP:20260424T150053
CREATED:20160119T140215Z
LAST-MODIFIED:20160119T140215Z
UID:95889-1453980600-1453984200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josep Roca
DESCRIPTION:From Systems Understanding to Personalized Medicine: Lessons and Recommendations based on a multi-disciplinary and translational analysis of COPD \nDr.  Josep Roca\, UB / IDIBAPS / Hospital Clinic\nSystems medicine\, using and adapting methods and approaches as developed within systems biology\, promises to be central in ongoing efforts of realizing and implementing personalized medicine in clinical practice and research. Here we review and critically assess opportunities and challenges using our work on COPD as a case study. We find that there are significant biomedical challenges in how to unravel complex multi-factorial components in disease initiation and progression producing different clinical phenotypes. Yet\, while such a system understanding of COPD is necessary\, there are other auxiliary challenges that need to be addressed in concert with a systems analysis of COPD. These include information and communication technologies (ICT) related issues such as data harmonization\, systematic handling of knowledge\, computational modeling\, and importantly their translation and support of clinical practice. For example\, clinical decision support systems need a seamless integration with new models and knowledge as systems analysis of COPD continues to develop. Our experience with clinical implementation of COPD highlights the need for a change of management including design of appropriate business models\, and adoption of ICT providing and supporting organizational interoperability among professional teams across healthcare tiers\, working around the patient. In conclusion\, in our hands the scope and efforts of systems medicine need to concurrently consider these aspects clinical implementation this driving the selection of most relevant issues and method in a systems analysis of disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josep-roca-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160128T113000
DTEND;TZID=UTC:20160128T123000
DTSTAMP:20260424T150053
CREATED:20160119T140215Z
LAST-MODIFIED:20160119T140338Z
UID:21059-1453980600-1453984200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josep Roca
DESCRIPTION:From Systems Understanding to Personalized Medicine: Lessons and Recommendations based on a multi-disciplinary and translational analysis of COPD \nDr.  Josep Roca\, UB / IDIBAPS / Hospital Clinic\nSystems medicine\, using and adapting methods and approaches as developed within systems biology\, promises to be central in ongoing efforts of realizing and implementing personalized medicine in clinical practice and research. Here we review and critically assess opportunities and challenges using our work on COPD as a case study. We find that there are significant biomedical challenges in how to unravel complex multi-factorial components in disease initiation and progression producing different clinical phenotypes. Yet\, while such a system understanding of COPD is necessary\, there are other auxiliary challenges that need to be addressed in concert with a systems analysis of COPD. These include information and communication technologies (ICT) related issues such as data harmonization\, systematic handling of knowledge\, computational modeling\, and importantly their translation and support of clinical practice. For example\, clinical decision support systems need a seamless integration with new models and knowledge as systems analysis of COPD continues to develop. Our experience with clinical implementation of COPD highlights the need for a change of management including design of appropriate business models\, and adoption of ICT providing and supporting organizational interoperability among professional teams across healthcare tiers\, working around the patient. In conclusion\, in our hands the scope and efforts of systems medicine need to concurrently consider these aspects clinical implementation this driving the selection of most relevant issues and method in a systems analysis of disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josep-roca/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160126T100000
DTEND;TZID=UTC:20160126T230000
DTSTAMP:20260424T150053
CREATED:20160120T140644Z
LAST-MODIFIED:20160120T140644Z
UID:95890-1453802400-1453849200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Michael Schmuker
DESCRIPTION:Neural computation in odour space\nDr. Michael Schmuker\, School of Engineering and Informatics\, University of Sussex\, UK\nOur sense of smell enables us to explore the world of chemical information. Yet\, our knowledge on the structure of chemical stimulus space still lacks far behind other modalities like vision or hearing. This lack of knowledge currently presents a major roadblock for understanding how the brain efficiently encodes chemical information. Moreover\, a better understanding of odour space\, and how it is processed in the brain\, may also enable bio-inspired design of efficient technical solutions for chemical sensing. \nIn this presentation\, I will give an overview on our research on how the olfactory systems of insects and vertebrates encode and transform chemical information on its way from the primary sensors to higher brain areas. These investigations inspired us to implement the key concepts of olfactory processing on a neuromorphic hardware system that uses spiking neuronal networks to perform pattern recognition in high-dimensional feature spaces. I will also present our recent findings on how to extract information about source distance from the fine-structure of gas plumes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-michael-schmuker-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160126T100000
DTEND;TZID=UTC:20160126T230000
DTSTAMP:20260424T150053
CREATED:20160120T140644Z
LAST-MODIFIED:20160120T140644Z
UID:21092-1453802400-1453849200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Michael Schmuker
DESCRIPTION:Neural computation in odour space\nDr. Michael Schmuker\, School of Engineering and Informatics\, University of Sussex\, UK\nOur sense of smell enables us to explore the world of chemical information. Yet\, our knowledge on the structure of chemical stimulus space still lacks far behind other modalities like vision or hearing. This lack of knowledge currently presents a major roadblock for understanding how the brain efficiently encodes chemical information. Moreover\, a better understanding of odour space\, and how it is processed in the brain\, may also enable bio-inspired design of efficient technical solutions for chemical sensing. \nIn this presentation\, I will give an overview on our research on how the olfactory systems of insects and vertebrates encode and transform chemical information on its way from the primary sensors to higher brain areas. These investigations inspired us to implement the key concepts of olfactory processing on a neuromorphic hardware system that uses spiking neuronal networks to perform pattern recognition in high-dimensional feature spaces. I will also present our recent findings on how to extract information about source distance from the fine-structure of gas plumes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-michael-schmuker/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160126T100000
DTEND;TZID=UTC:20160126T120000
DTSTAMP:20260424T150053
CREATED:20160126T113155Z
LAST-MODIFIED:20160126T113155Z
UID:21145-1453802400-1453809600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xavier Puñet
DESCRIPTION:“Design and Fabrication of Functionalized High Porous Poly(lactic acid)-based Scaffolds for Tissue Engineering”\nXavier Puñet\, Biomaterials for Regenerative Therapies group\nXavier will be defending his PhD thesis on Tuesday 26th January at 10:00 in the Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028\, Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xavier-punet/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160126T100000
DTEND;TZID=UTC:20160126T120000
DTSTAMP:20260424T150053
CREATED:20160126T113155Z
LAST-MODIFIED:20160126T113155Z
UID:95891-1453802400-1453809600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xavier Puñet
DESCRIPTION:“Design and Fabrication of Functionalized High Porous Poly(lactic acid)-based Scaffolds for Tissue Engineering”\nXavier Puñet\, Biomaterials for Regenerative Therapies group\nXavier will be defending his PhD thesis on Tuesday 26th January at 10:00 in the Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028\, Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xavier-punet-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T150000
DTEND;TZID=UTC:20160122T160000
DTSTAMP:20260424T150053
CREATED:20160114T100133Z
LAST-MODIFIED:20160118T093027Z
UID:20905-1453474800-1453478400@ibecbarcelona.eu
SUMMARY:IBEC Seminar (Bellvitge): Martin Lohse\, University of Würzburg
DESCRIPTION:Optical studies of receptor activation and signaling\nProf. Dr. Martin Lohse\, Chairman of the Rudolf Virchow Center for Experimental Biomedicine\, University of Würzburg\, Germany\nCyclic nucleotides (cAMP and cGMP) belong to the most ubiquitous intracellular messengers\, are produced in response to multiple stimuli\, act on several intracellular targets\, and regulate a vast array of biological functions. \nHowever\, in spite of the fundamental importance of these signaling systems\, very little is known about the temporal and spatial patterns of their production and action. In fact\, space and time seem to play almost no role in current concepts of intracellular signaling. To gain an insight into these dimensions\, we develop methods to create images of these second messengers in intact cells\, and to resolve these intracellular signals in space and in time.
URL:https://ibecbarcelona.eu/event/ibec-seminar-bellvitge-martin-lohse-university-of-wurzburg/
LOCATION:Aulari Nou de Bellvitge\, Sala de Graus (room 001\, ground floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T150000
DTEND;TZID=UTC:20160122T160000
DTSTAMP:20260424T150053
CREATED:20160114T100133Z
LAST-MODIFIED:20160114T100133Z
UID:95887-1453474800-1453478400@ibecbarcelona.eu
SUMMARY:IBEC Seminar (Bellvitge): Martin Lohse\, University of Würzburg
DESCRIPTION:Optical studies of receptor activation and signaling\nProf. Dr. Martin Lohse\, Chairman of the Rudolf Virchow Center for Experimental Biomedicine\, University of Würzburg\, Germany\nCyclic nucleotides (cAMP and cGMP) belong to the most ubiquitous intracellular messengers\, are produced in response to multiple stimuli\, act on several intracellular targets\, and regulate a vast array of biological functions. \nHowever\, in spite of the fundamental importance of these signaling systems\, very little is known about the temporal and spatial patterns of their production and action. In fact\, space and time seem to play almost no role in current concepts of intracellular signaling. To gain an insight into these dimensions\, we develop methods to create images of these second messengers in intact cells\, and to resolve these intracellular signals in space and in time.
URL:https://ibecbarcelona.eu/event/ibec-seminar-bellvitge-martin-lohse-university-of-wurzburg-2/
LOCATION:Aulari Nou de Bellvitge\, Sala de Graus (room 001\, ground floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T120000
DTSTAMP:20260424T150053
CREATED:20160114T095549Z
LAST-MODIFIED:20160118T081141Z
UID:20901-1453456800-1453464000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Silvia Pittolo
DESCRIPTION:“Development of light-modulated allosteric ligands for remote\, non-invasive control of neuronal receptors”\nSilvia Pittolo\, Nanoprobes and Nanoswitches group\nSilvia will be defending her PhD thesis on Friday 22nd January at 10:00 in the Aulari Nou de Bellvitge\, room 402 (4th floor) at the Bellvitge Campus. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-silvia-pittolo/
LOCATION:Aulari Nou de Bellvitge\, room 402 (4th floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T120000
DTSTAMP:20260424T150053
CREATED:20160114T095549Z
LAST-MODIFIED:20160114T095549Z
UID:95886-1453456800-1453464000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Silvia Pittolo
DESCRIPTION:“Development of light-modulated allosteric ligands for remote\, non-invasive control of neuronal receptors”\nSilvia Pittolo\, Nanoprobes and Nanoswitches group\nSilvia will be defending her PhD thesis on Friday 22nd January at 10:00 in the Aulari Nou de Bellvitge\, room 402 (4th floor) at the Bellvitge Campus. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-silvia-pittolo-2/
LOCATION:Aulari Nou de Bellvitge\, room 402 (4th floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T110000
DTSTAMP:20260424T150053
CREATED:20151027T094305Z
LAST-MODIFIED:20151027T094305Z
UID:95875-1453456800-1453460400@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Ana María Solórzano and Joan Martí Muñoz
DESCRIPTION:Carbon Monoxide Poisoning: Societal Impact\, Physiological Mechanism and Associated Chemical Instrumentation\nAna María Solórzano\, Signal and information processing for sensing systems group\nThe hazardousness of carbon monoxide is based on the inability of humans to detect it. Carbon monoxide is not irritating and has no color\, odor or either taste. The exposure to this gas can starve critical body organs specially vital organs like brain and heart. \nThe study and analysis of CO poisoning is not new. Even though in the last decades the society has been raised awareness on CO hazard\, accidental deaths are still produced by exposure to this gas. \nThe health effects of the CO poisoning depend on its concentration and time exposure. Health problems are noticeable with concentrations since 0.01% (100ppm).; this is the reason that the medical Instrumentation is an essential tool for the detection of CO. There is a kind of instrumentation\, which detects CO in the bloodstream\, and in the atmosphere but the early detection of this compound still is a challenge. \nWe are exploring how multi gas sensor arrays can be an effective solution to detect CO faster than typical alarms. \n  \nCalcium releasing ormoglass coated PLA nanofibers: A new approach for bone regeneration\nJoan Martí Muñoz\, Biomaterials for regenerative therapies group\nBone fracture healing has become a serious problem in the last decades in part due to the increase in life expectancy (1). The use of strategies that help body to restore bone are needed to increase the quality life of people suffering this problem. Among this strategies\, the use of natural sources such as; bone\, growth factors and other biomolecules has become an efficient option\, but present some limitations like money cost\, amount limitation and storage\, extra surgeries\, rejection and possible disease transmission (1). \nThe use of synthetic materials can be an effective option. However they need to be tuned to include the proper bioactive signals. Hybrid materials are and interesting alternative. Their organic phase\, normally a biodegradable biopolymer\, holds the mechanical stress while their inorganic phase\, a glass or ceramic\, provides the needed bioactivity to recruit cells and produce bone. In many cases\, the masking of the bioactive inorganic phase embedded in the organic matrix and undesired phase-detachments must be solved to increase efectiveness (2). Another limitation is the poor vascularization that synthetic materials induce. \nPrevious studies in our group demonstrated that extracellular Ca2+ release can promote angiogenesis (3). Here we present two different strategies: the first one consisting in CaP Ti-doped degradable ormoglass nanoparticles embedded inside polylactic acid (PLA) electrospun bioresorbable nanofibers; the second one consisting in CaP Si-doped degradable ormoglass nanoparticles (2) covalently attached on the surface of PLA electrospun nanofibers. In both cases the Ca2+ release by the ormoglass nanoparticles may activate the proper cell responses while the polymer provides the needed support to hold the particles and allow tissue growth. In the second case the attempt is to solve nanoparticle masking and detachment. \n1 M. Navarro et al. J. R. Soc. Interface (2008) 5\, 1137-1158.\n2 N. Sachot et al. J. R. Soc. Interface (2013) 10\, 20130684.\n3 A. Aguirre et al. European Cells and Materials Vol. 24 2012 (pages 90-106). \n 
URL:https://ibecbarcelona.eu/event/phd-discussion-session-ana-maria-solorzano-and-joan-marti-munoz-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T110000
DTSTAMP:20260424T150053
CREATED:20151027T094305Z
LAST-MODIFIED:20160118T081841Z
UID:19437-1453456800-1453460400@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Ana María Solórzano and Joan Martí Muñoz
DESCRIPTION:Carbon Monoxide Poisoning: Societal Impact\, Physiological Mechanism and Associated Chemical Instrumentation\nAna María Solórzano\, Signal and information processing for sensing systems group\nThe hazardousness of carbon monoxide is based on the inability of humans to detect it. Carbon monoxide is not irritating and has no color\, odor or either taste. The exposure to this gas can starve critical body organs specially vital organs like brain and heart. \nThe study and analysis of CO poisoning is not new. Even though in the last decades the society has been raised awareness on CO hazard\, accidental deaths are still produced by exposure to this gas. \nThe health effects of the CO poisoning depend on its concentration and time exposure. Health problems are noticeable with concentrations since 0.01% (100ppm).; this is the reason that the medical Instrumentation is an essential tool for the detection of CO. There is a kind of instrumentation\, which detects CO in the bloodstream\, and in the atmosphere but the early detection of this compound still is a challenge. \nWe are exploring how multi gas sensor arrays can be an effective solution to detect CO faster than typical alarms. \n  \nCalcium releasing ormoglass coated PLA nanofibers: A new approach for bone regeneration\nJoan Martí Muñoz\, Biomaterials for regenerative therapies group\nBone fracture healing has become a serious problem in the last decades in part due to the increase in life expectancy (1). The use of strategies that help body to restore bone are needed to increase the quality life of people suffering this problem. Among this strategies\, the use of natural sources such as; bone\, growth factors and other biomolecules has become an efficient option\, but present some limitations like money cost\, amount limitation and storage\, extra surgeries\, rejection and possible disease transmission (1). \nThe use of synthetic materials can be an effective option. However they need to be tuned to include the proper bioactive signals. Hybrid materials are and interesting alternative. Their organic phase\, normally a biodegradable biopolymer\, holds the mechanical stress while their inorganic phase\, a glass or ceramic\, provides the needed bioactivity to recruit cells and produce bone. In many cases\, the masking of the bioactive inorganic phase embedded in the organic matrix and undesired phase-detachments must be solved to increase efectiveness (2). Another limitation is the poor vascularization that synthetic materials induce. \nPrevious studies in our group demonstrated that extracellular Ca2+ release can promote angiogenesis (3). Here we present two different strategies: the first one consisting in CaP Ti-doped degradable ormoglass nanoparticles embedded inside polylactic acid (PLA) electrospun bioresorbable nanofibers; the second one consisting in CaP Si-doped degradable ormoglass nanoparticles (2) covalently attached on the surface of PLA electrospun nanofibers. In both cases the Ca2+ release by the ormoglass nanoparticles may activate the proper cell responses while the polymer provides the needed support to hold the particles and allow tissue growth. In the second case the attempt is to solve nanoparticle masking and detachment. \n1 M. Navarro et al. J. R. Soc. Interface (2008) 5\, 1137-1158.\n2 N. Sachot et al. J. R. Soc. Interface (2013) 10\, 20130684.\n3 A. Aguirre et al. European Cells and Materials Vol. 24 2012 (pages 90-106). \n 
URL:https://ibecbarcelona.eu/event/phd-discussion-session-ana-maria-solorzano-and-joan-marti-munoz/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151218T110000
DTEND;TZID=UTC:20151218T130000
DTSTAMP:20260424T150053
CREATED:20151126T134551Z
LAST-MODIFIED:20151126T134551Z
UID:95883-1450436400-1450443600@ibecbarcelona.eu
SUMMARY:PhD Defence: Aitor Sánchez
DESCRIPTION:“Biomimetic hydrogels for in situ bone tissue engineering. Nature-inspired crosslinking methods as a tool to tune scaffold physical properties”\nAitor Sánchez\, Biomaterials for Regenerative Therapies group\nAitor will be defending his PhD thesis on Friday 18th December at 11:00 in the Sala d’Actes\, Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-defence-aitor-sanchez-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151218T110000
DTEND;TZID=UTC:20151218T130000
DTSTAMP:20260424T150053
CREATED:20151126T134551Z
LAST-MODIFIED:20151126T134551Z
UID:19884-1450436400-1450443600@ibecbarcelona.eu
SUMMARY:PhD Defence: Aitor Sánchez
DESCRIPTION:“Biomimetic hydrogels for in situ bone tissue engineering. Nature-inspired crosslinking methods as a tool to tune scaffold physical properties”\nAitor Sánchez\, Biomaterials for Regenerative Therapies group\nAitor will be defending his PhD thesis on Friday 18th December at 11:00 in the Sala d’Actes\, Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-defence-aitor-sanchez/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151217T190000
DTEND;TZID=UTC:20151217T190000
DTSTAMP:20260424T150053
CREATED:20151130T155937Z
LAST-MODIFIED:20151209T073011Z
UID:19901-1450378800-1450378800@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2015
DESCRIPTION:We’re delighted to invite all IBECers to the biggest\, best IBEC Christmas Party Ever! \nThis year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. If you take part\, you’ll be in with a chance of winning a fabulous prize provided by our sponsors\, such as a food hamper\, a digital camera\, a tablet\, or a weekend break. If you’d like to suggest your favourite charity to be a beneficiary of this fundraising\, fill in the form in i-Box in the intranet (deadline 9th December)). \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises to be a fabulous way to kick-start the festive season!\n\nRegistration here.
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2015/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151217T190000
DTEND;TZID=UTC:20151217T190000
DTSTAMP:20260424T150053
CREATED:20151130T155937Z
LAST-MODIFIED:20151130T155937Z
UID:95884-1450378800-1450378800@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2015
DESCRIPTION:We’re delighted to invite all IBECers to the biggest\, best IBEC Christmas Party Ever! \nThis year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. If you take part\, you’ll be in with a chance of winning a fabulous prize provided by our sponsors\, such as a food hamper\, a digital camera\, a tablet\, or a weekend break. If you’d like to suggest your favourite charity to be a beneficiary of this fundraising\, fill in the form in i-Box in the intranet (deadline 9th December)). \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises to be a fabulous way to kick-start the festive season!\n\nRegistration here.
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2015-2/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151211T120000
DTEND;TZID=UTC:20151211T130000
DTSTAMP:20260424T150053
CREATED:20151029T093053Z
LAST-MODIFIED:20151029T093053Z
UID:19457-1449835200-1449838800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Roberto de la Rica
DESCRIPTION:Bioplasmonics in nanofabrication\, biosensing and nanomedicine\nRoberto de la Rica\, University of Strathclyde\nIn this talk I will show several bio-enabled and bio-inspired approaches for growing and assembling plasmonic nanoparticles and their applications in biosensing and nanomedicine. I will explain how to use enzyme nanoreactors to guide the growth of plasmonic nanoparticles with different morphologies\, an approach that can be used to design ultrasensitive biosensors and new nanolithography tools. [1-4] \nI will also show a method for assembling nanoparticle superstructures with crystallographically aligned building blocks5 that possess improved plasmonic properties derived from their 3D organization. When assembled on magnetic supports these plasmonic superstructures can be used for as multifunctional intracellular sensors as well as for heat generation in thermal therapy. \n[1] Nat. Mater. 11\, 604 (2012);[2] Nat. Nanotechnol. 7\, 821\, 2012; [3] Nat. Protocol. 8\, 1759 (2013); [4] Adv. Funct. Mater. 24\, 3692 (2104); [5] JACS 133\, 2875 (2011)
URL:https://ibecbarcelona.eu/event/ibec-seminar-roberto-de-la-rica/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151211T120000
DTEND;TZID=UTC:20151211T130000
DTSTAMP:20260424T150053
CREATED:20151029T093053Z
LAST-MODIFIED:20151029T093053Z
UID:95876-1449835200-1449838800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Roberto de la Rica
DESCRIPTION:Bioplasmonics in nanofabrication\, biosensing and nanomedicine\nRoberto de la Rica\, University of Strathclyde\nIn this talk I will show several bio-enabled and bio-inspired approaches for growing and assembling plasmonic nanoparticles and their applications in biosensing and nanomedicine. I will explain how to use enzyme nanoreactors to guide the growth of plasmonic nanoparticles with different morphologies\, an approach that can be used to design ultrasensitive biosensors and new nanolithography tools. [1-4] \nI will also show a method for assembling nanoparticle superstructures with crystallographically aligned building blocks5 that possess improved plasmonic properties derived from their 3D organization. When assembled on magnetic supports these plasmonic superstructures can be used for as multifunctional intracellular sensors as well as for heat generation in thermal therapy. \n[1] Nat. Mater. 11\, 604 (2012);[2] Nat. Nanotechnol. 7\, 821\, 2012; [3] Nat. Protocol. 8\, 1759 (2013); [4] Adv. Funct. Mater. 24\, 3692 (2104); [5] JACS 133\, 2875 (2011)
URL:https://ibecbarcelona.eu/event/ibec-seminar-roberto-de-la-rica-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151209T110000
DTEND;TZID=UTC:20151209T130000
DTSTAMP:20260424T150053
CREATED:20151117T133654Z
LAST-MODIFIED:20151117T133811Z
UID:19772-1449658800-1449666000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Ernest Moles
DESCRIPTION:“Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy”\nErnest Moles\, Nanomalaria joint unit\nErnest will be defending his PhD thesis on Wednesday 9th December at 11:00 in the Aula Magna of the Faculty of Pharmacy\, University of Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ernest-moles/
LOCATION:Aula Magna\, Faculty of Pharmacy\, Av. Joan XXIII s/n\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151209T110000
DTEND;TZID=UTC:20151209T130000
DTSTAMP:20260424T150053
CREATED:20151117T133654Z
LAST-MODIFIED:20151117T133654Z
UID:95880-1449658800-1449666000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Ernest Moles
DESCRIPTION:“Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy”\nErnest Moles\, Nanomalaria joint unit\nErnest will be defending his PhD thesis on Wednesday 9th December at 11:00 in the Aula Magna of the Faculty of Pharmacy\, University of Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ernest-moles-2/
LOCATION:Aula Magna\, Faculty of Pharmacy\, Av. Joan XXIII s/n\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151203T100000
DTEND;TZID=UTC:20151203T230000
DTSTAMP:20260424T150053
CREATED:20151126T075237Z
LAST-MODIFIED:20151126T075237Z
UID:95882-1449136800-1449183600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alexandre Perera
DESCRIPTION:Data evaluation in Metabolomics\, preprocessing\, analysis and biological enrichment\nAlexandre Perera\, B2SLab Bioinformatics and Biomedical Signals Laboratory\, UPC\nThis talk will depict the last efforts by the B2Slab on the processing of LC/MS metabolomics data. First\, we describe a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which intensity drift effects are modelled through Common Principal Components Analysis and removed from original data. Secondly\, we propose a new processing workflow based on peak aggregation techniques. We show that the predictive power of the data is improved when the peak aggregation techniques are used regardless of the prediction technique used. We also describe a new computational tool to perform end-to-end analysis (MAIT) coded under the R environment. MAIT package is highly modular and programmable which allow the users to perform their personalised LC/MS data analysis workflows. MAIT is able to take the raw output files from an LC/MS instrument as an input and\, by applying a set of functions\, provide a metabolite identification table as a result. Finally\, we introduce FELLA\, a set of algorithms for biological interpretation of metabolomic data in light of existing knowledge extracted from annotation databases\, extending the concept of pathway enrichment into metabolomics. FELLA is based on diffusion process on a graph representation of a knowledge base\, while statistically testing solutions against analytical null diffusion distributions. Results are provided comparing the tools with sate of the art methods on different network types.\n\n[1] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. Peak Aggregation as an Innovative Strategy for Improving the Predictive Power of LC-MS Metabolomic Profiles. Analytical Chemistry 86 (5)\, 2320–5 (2014).\n[2] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit). Bioinformatics 30(13):1937-9 (2014).\n[3] Fernández-Albert F.\, Llorach R.\, Garcia-Aloy M\, Ziyatdinov A\, Andrés-Lacueva C.\, Perera-Lluna A. Intensity drift removal in LC/MS metabolomics by Common Variance Compensation. Bioinformatics 30(20)\, 2898-2905 (2014)\n[4] Domingo-Almenara\, X.\, Perera\, A.\, Ramírez\, N.\, Cañellas\, N.\, Correig\, X.\, & Brezmes\, J. (2015). Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. Journal of Chromatography A\, 1409\, 226-233\n[5] Ziyatdinov\, A.; Marco\, S.; Chaudry\, A.; Persaud\, K.; Caminal\, P.; Perera\, A. Drift compensation of gas sensor array data by common principal component analysis. Sensors and Actuators B: Chemical 146\, 460-5 (2010).
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandre-perera-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151203T100000
DTEND;TZID=UTC:20151203T230000
DTSTAMP:20260424T150053
CREATED:20151126T075237Z
LAST-MODIFIED:20151126T075237Z
UID:19883-1449136800-1449183600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alexandre Perera
DESCRIPTION:Data evaluation in Metabolomics\, preprocessing\, analysis and biological enrichment\nAlexandre Perera\, B2SLab Bioinformatics and Biomedical Signals Laboratory\, UPC\nThis talk will depict the last efforts by the B2Slab on the processing of LC/MS metabolomics data. First\, we describe a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which intensity drift effects are modelled through Common Principal Components Analysis and removed from original data. Secondly\, we propose a new processing workflow based on peak aggregation techniques. We show that the predictive power of the data is improved when the peak aggregation techniques are used regardless of the prediction technique used. We also describe a new computational tool to perform end-to-end analysis (MAIT) coded under the R environment. MAIT package is highly modular and programmable which allow the users to perform their personalised LC/MS data analysis workflows. MAIT is able to take the raw output files from an LC/MS instrument as an input and\, by applying a set of functions\, provide a metabolite identification table as a result. Finally\, we introduce FELLA\, a set of algorithms for biological interpretation of metabolomic data in light of existing knowledge extracted from annotation databases\, extending the concept of pathway enrichment into metabolomics. FELLA is based on diffusion process on a graph representation of a knowledge base\, while statistically testing solutions against analytical null diffusion distributions. Results are provided comparing the tools with sate of the art methods on different network types.\n\n[1] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. Peak Aggregation as an Innovative Strategy for Improving the Predictive Power of LC-MS Metabolomic Profiles. Analytical Chemistry 86 (5)\, 2320–5 (2014).\n[2] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit). Bioinformatics 30(13):1937-9 (2014).\n[3] Fernández-Albert F.\, Llorach R.\, Garcia-Aloy M\, Ziyatdinov A\, Andrés-Lacueva C.\, Perera-Lluna A. Intensity drift removal in LC/MS metabolomics by Common Variance Compensation. Bioinformatics 30(20)\, 2898-2905 (2014)\n[4] Domingo-Almenara\, X.\, Perera\, A.\, Ramírez\, N.\, Cañellas\, N.\, Correig\, X.\, & Brezmes\, J. (2015). Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. Journal of Chromatography A\, 1409\, 226-233\n[5] Ziyatdinov\, A.; Marco\, S.; Chaudry\, A.; Persaud\, K.; Caminal\, P.; Perera\, A. Drift compensation of gas sensor array data by common principal component analysis. Sensors and Actuators B: Chemical 146\, 460-5 (2010).
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandre-perera/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T120000
DTEND;TZID=UTC:20151127T130000
DTSTAMP:20260424T150053
CREATED:20151106T080207Z
LAST-MODIFIED:20151123T092950Z
UID:19561-1448625600-1448629200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Chia-Fu Chou
DESCRIPTION:Low-copy number biomolecular analysis with dielectrophoretic enrichment /trapping via molecular dam and plasmonic electrode nanogaps\nChia-Fu Chou\, Senior Research Fellow/Professor\, Institute of Physics\, Academia Sinica\, Taiwan\nNanoscale structures\, such as electrode nanogap and nanofluidic confinement\, given its simplicity in geometry\, nevertheless offer unique platforms for the study of molecular and cellular biophysics\, with the potential for bioanalytical applications [1-5]. For low-copy number molecule detection\, we developed two versatile analysis platforms for the manipulation and sensing of biomolecules. In the first scenario\, sub-30 nm insulating nanoconstriction operating under the balance of negative dielectrophoresis (DEP)\, electrophoresis\, and electroosmosis\, serves as molecular dam\, enables protein enrichment of 105-fold in 20 seconds [6]\, which can then be coupled with graphene-modified electrode for sensitive electrochemical detection of proteins and peptides [7\, 8]. In the second scenario\, an array of Ti/Au electrode nanogaps with sub-10 nm gap size function as templates for AC DEP-based molecular trapping\, plasmonic hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements\, and fluorescence imaging. During molecular trapping\, recorded Raman spectra\, conductance measurements across the nanogaps and fluorescence imaging show unambiguously the presence and characteristics of the trapped molecules\, demonstrated with R-phycoerythrin [9] and Alzheimer’s disease associated biomarkers A-beta 40 and 42 peptides. Our platforms open up simple ways for multifunctional low-concentration heterogeneous sample analysis.\n[1] L.J. Guo\, X. Cheng\, C.F. Chou\, Nano Lett. 4\, 69 (2004).\n[2] J. Gu\, R. Gupta\, C.F. Chou\, Q. Wei\, F. Zenhausern\, Lab Chip 7\, 1198 (2007).\n[3] J.W. Yeh\, A. Taloni\, Y.L. Chen\, C.F. Chou\, Nano Lett. 12\, 1597 (2012). [Research Highlights\, Nature 482\, 442 (2012)].\n[4] J.P. Shen and C.F. Chou\, Biomicrofluidics 8\, 041103 (2014).\n[5] K.K. Sriram\, J.W. Yeh\, Y.L. Lin\, Y.R. Chang\, C.F. Chou\, Nucleic Acids Res. 42\, e85 (2014).\n[6] K.T. Liao\, C.F. Chou\, J. Am. Chem. Soc. 134\, 8742 (2012). [JACS Spotlights: JACS 134\, 10307 (2012)]\n[7] B. Sanghavi\, W. Varhue\, J. Chávez\, C.F. Chou\, N. S. Swami\, Anal. Chem. 86\, 4120 (2014\,).\n[8] B.J. Sanghavi\, W. Varhue\, A. Rohani\, K.T. Liao\, L. Bazydlo\, C.F. Chou\, N. S. Swami\, Lab Chip 2015\, DOI: 10.1039/c5lc00840a.\n[9] L. Lesser-Rojas\, P. Ebbinghaus\, G. Vasan\, M.L. Chu\, A. Erbe\, C.F. Chou\, Nano Lett. 14\, 2242 (2014).
URL:https://ibecbarcelona.eu/event/ibec-seminar-chia-fu-chou/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T120000
DTEND;TZID=UTC:20151127T130000
DTSTAMP:20260424T150053
CREATED:20151106T080207Z
LAST-MODIFIED:20151106T080207Z
UID:95877-1448625600-1448629200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Chia-Fu Chou
DESCRIPTION:Low-copy number biomolecular analysis with dielectrophoretic enrichment /trapping via molecular dam and plasmonic electrode nanogaps\nChia-Fu Chou\, Senior Research Fellow/Professor\, Institute of Physics\, Academia Sinica\, Taiwan\nNanoscale structures\, such as electrode nanogap and nanofluidic confinement\, given its simplicity in geometry\, nevertheless offer unique platforms for the study of molecular and cellular biophysics\, with the potential for bioanalytical applications [1-5]. For low-copy number molecule detection\, we developed two versatile analysis platforms for the manipulation and sensing of biomolecules. In the first scenario\, sub-30 nm insulating nanoconstriction operating under the balance of negative dielectrophoresis (DEP)\, electrophoresis\, and electroosmosis\, serves as molecular dam\, enables protein enrichment of 105-fold in 20 seconds [6]\, which can then be coupled with graphene-modified electrode for sensitive electrochemical detection of proteins and peptides [7\, 8]. In the second scenario\, an array of Ti/Au electrode nanogaps with sub-10 nm gap size function as templates for AC DEP-based molecular trapping\, plasmonic hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements\, and fluorescence imaging. During molecular trapping\, recorded Raman spectra\, conductance measurements across the nanogaps and fluorescence imaging show unambiguously the presence and characteristics of the trapped molecules\, demonstrated with R-phycoerythrin [9] and Alzheimer’s disease associated biomarkers A-beta 40 and 42 peptides. Our platforms open up simple ways for multifunctional low-concentration heterogeneous sample analysis.\n[1] L.J. Guo\, X. Cheng\, C.F. Chou\, Nano Lett. 4\, 69 (2004).\n[2] J. Gu\, R. Gupta\, C.F. Chou\, Q. Wei\, F. Zenhausern\, Lab Chip 7\, 1198 (2007).\n[3] J.W. Yeh\, A. Taloni\, Y.L. Chen\, C.F. Chou\, Nano Lett. 12\, 1597 (2012). [Research Highlights\, Nature 482\, 442 (2012)].\n[4] J.P. Shen and C.F. Chou\, Biomicrofluidics 8\, 041103 (2014).\n[5] K.K. Sriram\, J.W. Yeh\, Y.L. Lin\, Y.R. Chang\, C.F. Chou\, Nucleic Acids Res. 42\, e85 (2014).\n[6] K.T. Liao\, C.F. Chou\, J. Am. Chem. Soc. 134\, 8742 (2012). [JACS Spotlights: JACS 134\, 10307 (2012)]\n[7] B. Sanghavi\, W. Varhue\, J. Chávez\, C.F. Chou\, N. S. Swami\, Anal. Chem. 86\, 4120 (2014\,).\n[8] B.J. Sanghavi\, W. Varhue\, A. Rohani\, K.T. Liao\, L. Bazydlo\, C.F. Chou\, N. S. Swami\, Lab Chip 2015\, DOI: 10.1039/c5lc00840a.\n[9] L. Lesser-Rojas\, P. Ebbinghaus\, G. Vasan\, M.L. Chu\, A. Erbe\, C.F. Chou\, Nano Lett. 14\, 2242 (2014).
URL:https://ibecbarcelona.eu/event/ibec-seminar-chia-fu-chou-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T100000
DTEND;TZID=UTC:20151127T110000
DTSTAMP:20260424T150053
CREATED:20151027T093619Z
LAST-MODIFIED:20151119T152104Z
UID:19436-1448618400-1448622000@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Maria Chiara Biagi and Roger Oria
DESCRIPTION:Nanoscale dielectric characterization of single bacterial cells at microwave frequency\nMaria Chiara Biagi\, Nanoscale Bioelectrical Characterization group\nInformation on the microwave electromagnetic properties of cell suspensions and tissues has already led to important application in therapeutic and diagnostic. In recent years\, a new microscopy technique has appeared\, able to resolve the electromagnetic response at GHz even further down\, at nanoscale spatial resolution: Scanning Microwave Microscope (SMM). Its application to single cells would possibly allow not just to scale down the existing medical and biological techniques\, but would also give rise to a new class of label-free imaging methods based on dielectric contrast. Yet\, the quantification of the intrinsic dielectric properties (i.e. complex permittivity) of non-planar irregular shaped objects like single cells from the standard SMM images remains a challenge\, because the experimental signal is greatly affected by the huge presence of non-local contributions. \nWe developed a methodology to quantify and remove them\, which consequently enables to obtain images related only to the intrinsic dielectric response of the sample. These images are then suitable for a quantitative analysis and\, in combination with 3D finite element numerical calculations\, a map of the complex permittivity of the cell can be obtained.\nWe have applied this procedure to a single bacterial cell (E. coli) and quantified for the first time its complex permittivity at ~19 GHz\, in dry and humid conditions. \n  \nInterplay between integrin expression\, clustering\, and substrate rigidity in cell mechanical response\nRoger Oria\, Cellular and respiratory biomechanics group\nEssential cell functions such as proliferation\, differentiation\, or migration are determined by the rigidity and composition of the extracellular matrix (ECM). Understanding this interaction requires a precise control of ECM mechanical properties and molecular distribution of cell-ECM ligands\, as well as the ability to measure the mechanical forces transmitted at the cell-ECM interface. To address this issue\, we have developed an approach based on polyacrylamide substrates of tunable rigidity decorated with nanometric regular hexagonal patterns of RGD ligands\, which serve as binding sites for single integrins. By using this system\, we have systematically analysed cell response in terms of force transmission\, rearward flow and integrin recruitment after varying (i) gel rigidity\, (ii) spacing and spatial distribution between RGD ligands\, and (iii) integrin expression levels. Our results show that cell response and force generation are critically dependent on all factors. We also demonstrate the counter-intuitive fact that at specific ECM rigidities cells increase force transmission as the spacing between integrins increases from 50 to 100 nm. Our findings indicate that mechanical homeostasis can be tuned by cells using strategies based on integrin expression\, clustering of ECM ligands\, or ECM rigidity\, and that an in-depth understanding of cell mechanical responses requires the consideration of all those factors. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-session-maria-chiara-and-roger-oria/
CATEGORIES:PhD Discussions Session
END:VEVENT
END:VCALENDAR