BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Institute for Bioengineering of Catalonia X-ORIGINAL-URL:https://ibecbarcelona.eu X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:UTC BEGIN:STANDARD TZOFFSETFROM:+0000 TZOFFSETTO:+0000 TZNAME:UTC DTSTART:20140101T000000 END:STANDARD END:VTIMEZONE BEGIN:VTIMEZONE TZID:Europe/Madrid BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20140330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20141026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20150329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20151025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20160327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20161030T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=UTC:20151127T100000 DTEND;TZID=UTC:20151127T110000 DTSTAMP:20260426T132616 CREATED:20151027T093619Z LAST-MODIFIED:20151027T093619Z UID:95874-1448618400-1448622000@ibecbarcelona.eu SUMMARY:PhD Discussions Session: Maria Chiara Biagi and Roger Oria DESCRIPTION:Nanoscale dielectric characterization of single bacterial cells at microwave frequency\nMaria Chiara Biagi\, Nanoscale Bioelectrical Characterization group\nInformation on the microwave electromagnetic properties of cell suspensions and tissues has already led to important application in therapeutic and diagnostic. In recent years\, a new microscopy technique has appeared\, able to resolve the electromagnetic response at GHz even further down\, at nanoscale spatial resolution: Scanning Microwave Microscope (SMM). Its application to single cells would possibly allow not just to scale down the existing medical and biological techniques\, but would also give rise to a new class of label-free imaging methods based on dielectric contrast. Yet\, the quantification of the intrinsic dielectric properties (i.e. complex permittivity) of non-planar irregular shaped objects like single cells from the standard SMM images remains a challenge\, because the experimental signal is greatly affected by the huge presence of non-local contributions. \nWe developed a methodology to quantify and remove them\, which consequently enables to obtain images related only to the intrinsic dielectric response of the sample. These images are then suitable for a quantitative analysis and\, in combination with 3D finite element numerical calculations\, a map of the complex permittivity of the cell can be obtained.\nWe have applied this procedure to a single bacterial cell (E. coli) and quantified for the first time its complex permittivity at ~19 GHz\, in dry and humid conditions. \n  \nInterplay between integrin expression\, clustering\, and substrate rigidity in cell mechanical response\nRoger Oria\, Cellular and respiratory biomechanics group\nEssential cell functions such as proliferation\, differentiation\, or migration are determined by the rigidity and composition of the extracellular matrix (ECM). Understanding this interaction requires a precise control of ECM mechanical properties and molecular distribution of cell-ECM ligands\, as well as the ability to measure the mechanical forces transmitted at the cell-ECM interface. To address this issue\, we have developed an approach based on polyacrylamide substrates of tunable rigidity decorated with nanometric regular hexagonal patterns of RGD ligands\, which serve as binding sites for single integrins. By using this system\, we have systematically analysed cell response in terms of force transmission\, rearward flow and integrin recruitment after varying (i) gel rigidity\, (ii) spacing and spatial distribution between RGD ligands\, and (iii) integrin expression levels. Our results show that cell response and force generation are critically dependent on all factors. We also demonstrate the counter-intuitive fact that at specific ECM rigidities cells increase force transmission as the spacing between integrins increases from 50 to 100 nm. Our findings indicate that mechanical homeostasis can be tuned by cells using strategies based on integrin expression\, clustering of ECM ligands\, or ECM rigidity\, and that an in-depth understanding of cell mechanical responses requires the consideration of all those factors. \n  URL:https://ibecbarcelona.eu/event/phd-discussions-session-maria-chiara-and-roger-oria-2/ CATEGORIES:PhD Discussions Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151123T150000 DTEND;TZID=UTC:20151123T170000 DTSTAMP:20260426T132616 CREATED:20151119T115401Z LAST-MODIFIED:20151119T115612Z UID:19829-1448290800-1448298000@ibecbarcelona.eu SUMMARY:PhD Thesis defence: Lorena De Oñate DESCRIPTION:“Research on cardiac differentiation from human pluripotent stem cells: how to get beating cells in a dish”\nLorena De Oñate\, Pluripotent Stem Cells and Activation of Endogenous Tissue Programs for Organ Regeneration group\nLorena will be defending her PhD thesis on Monday 23rd November at 15:00 in the Ramón y Cajal Room at the Parc de Recerca Biomèdica (PRBB). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lorena-de-onate/ LOCATION:Sala Ramón y Cajal\, Parc de Recerca Biomèdica (PRBB)\, Barcelona\, Spain CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151123T150000 DTEND;TZID=UTC:20151123T170000 DTSTAMP:20260426T132616 CREATED:20151119T115401Z LAST-MODIFIED:20151119T115401Z UID:95881-1448290800-1448298000@ibecbarcelona.eu SUMMARY:PhD Thesis defence: Lorena De Oñate DESCRIPTION:“Research on cardiac differentiation from human pluripotent stem cells: how to get beating cells in a dish”\nLorena De Oñate\, Pluripotent Stem Cells and Activation of Endogenous Tissue Programs for Organ Regeneration group\nLorena will be defending her PhD thesis on Monday 23rd November at 15:00 in the Ramón y Cajal Room at the Parc de Recerca Biomèdica (PRBB). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lorena-de-onate-2/ LOCATION:Sala Ramón y Cajal\, Parc de Recerca Biomèdica (PRBB)\, Barcelona\, Spain CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151119T120000 DTEND;TZID=UTC:20151119T130000 DTSTAMP:20260426T132616 CREATED:20151109T154810Z LAST-MODIFIED:20151109T154810Z UID:95878-1447934400-1447938000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Luis de Lecea DESCRIPTION:Optogenetic control of arousal\nLuis de Lecea\, Department of Psychiatry and Behavioral Sciences\, Stanford University School of Medicine\nChanges in arousal states are at the core of most neuropsychiatric disorders. Several groups of monoaminergic neurons have long been known to facilitate arousal state transitions. Here we will review the role of hypocretin/orexin neurons in the dynamics of sleep-to-wake transitions. I will also show data demonstrating that dopaminergic neurons of the ventral tegmental area (VTA) directly and causally control the generation and maintenance of electrocortical and behavioral arousal. Combining chemogenetic and optogenetic tools with polysomnographic recordings in mice\, we show that activity in VTA-dopaminergic neurons is necessary for arousal\, and that their chemogenetic inhibition suppresses wakefulness to promote both non-rapid eye movement (NREM) and REM sleep. Moreover\, chemogenetic inhibition of VTA-dopaminergic neurons suppresses wakefulness even in the face of highly salient stimuli related to reproduction\, feeding and predation. Nevertheless\, prior to inducing sleep\, chemogenetic inhibition of VTA-dopaminergic neurons promotes goal-directed and sleep-related nest building behavior. Optogenetic stimulation\, in contrast\, initiates and maintains long-term wakefulness and suppresses sleep and sleep-related nesting behavior. We further show that the nucleus accumbens (NAc) circuit\, and not the medial prefrontal cortex (mPFC)\, mediates most of VTA-dopaminergic effects on arousal. After collecting data from multiple brain structures involved in arousal states\, we propose a computational model that assigns probabilities to optogenetically-induced arousal state transitions in individual brain structures. We identify feedback\, redundancy\, and gating hierarchy as three fundamental aspects of this model. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into arousal state dynamics as well as arousal-related disorders. URL:https://ibecbarcelona.eu/event/ibec-seminar-luis-de-lecea-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151119T120000 DTEND;TZID=UTC:20151119T130000 DTSTAMP:20260426T132616 CREATED:20151109T154810Z LAST-MODIFIED:20151113T074152Z UID:19587-1447934400-1447938000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Luis de Lecea DESCRIPTION:Optogenetic control of arousal\nLuis de Lecea\, Department of Psychiatry and Behavioral Sciences\, Stanford University School of Medicine\nChanges in arousal states are at the core of most neuropsychiatric disorders. Several groups of monoaminergic neurons have long been known to facilitate arousal state transitions. Here we will review the role of hypocretin/orexin neurons in the dynamics of sleep-to-wake transitions. I will also show data demonstrating that dopaminergic neurons of the ventral tegmental area (VTA) directly and causally control the generation and maintenance of electrocortical and behavioral arousal. Combining chemogenetic and optogenetic tools with polysomnographic recordings in mice\, we show that activity in VTA-dopaminergic neurons is necessary for arousal\, and that their chemogenetic inhibition suppresses wakefulness to promote both non-rapid eye movement (NREM) and REM sleep. Moreover\, chemogenetic inhibition of VTA-dopaminergic neurons suppresses wakefulness even in the face of highly salient stimuli related to reproduction\, feeding and predation. Nevertheless\, prior to inducing sleep\, chemogenetic inhibition of VTA-dopaminergic neurons promotes goal-directed and sleep-related nest building behavior. Optogenetic stimulation\, in contrast\, initiates and maintains long-term wakefulness and suppresses sleep and sleep-related nesting behavior. We further show that the nucleus accumbens (NAc) circuit\, and not the medial prefrontal cortex (mPFC)\, mediates most of VTA-dopaminergic effects on arousal. After collecting data from multiple brain structures involved in arousal states\, we propose a computational model that assigns probabilities to optogenetically-induced arousal state transitions in individual brain structures. We identify feedback\, redundancy\, and gating hierarchy as three fundamental aspects of this model. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into arousal state dynamics as well as arousal-related disorders. URL:https://ibecbarcelona.eu/event/ibec-seminar-luis-de-lecea/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151118T171500 DTEND;TZID=UTC:20151118T203000 DTSTAMP:20260426T132616 CREATED:20151110T131625Z LAST-MODIFIED:20151110T131625Z UID:95879-1447866900-1447878600@ibecbarcelona.eu SUMMARY:Setmana de la Ciència 2015 DESCRIPTION:Setmana de la Ciència 2015\nParc Científic de Barcelona\, Sala Dolors Aleu\nEl dimecres 18 de novembre a la tarda\, en el context de la celebració de la SETMANA DE LA CIÈNCIA\, volem que ens acompanyis en una jornada científica singular. \nPodràs visitar els laboratoris per conèixer la recerca més puntera en bioenginyeria\, i sota el títol “Fem visibles les forces cel·lulars”\, el Professor Xavier Trepat explicarà com i perquè estudien les forces que fan les cèl·lules. \nA més a més\, per celebrar que aquest any és l’Any Internacional de la llum\, finalitzarem la visita amb un brindis i un petit concert amb inspiració científica.\nAquesta activitat és gratuïta\, està dirigida a majos de 16 anys i les places són limitades\, per tant cal INSCRIURE’S URL:https://ibecbarcelona.eu/event/setmana-de-la-ciencia-2015-2/ LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain CATEGORIES:Outreach / Fair / Festival END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151118T171500 DTEND;TZID=UTC:20151118T203000 DTSTAMP:20260426T132616 CREATED:20151110T131625Z LAST-MODIFIED:20170801T131002Z UID:19592-1447866900-1447878600@ibecbarcelona.eu SUMMARY:Setmana de la Ciència 2015 DESCRIPTION:Setmana de la Ciència 2015\nParc Científic de Barcelona\, Sala Dolors Aleu\nEl dimecres 18 de novembre a la tarda\, en el context de la celebració de la SETMANA DE LA CIÈNCIA\, volem que ens acompanyis en una jornada científica singular. \nPodràs visitar els laboratoris per conèixer la recerca més puntera en bioenginyeria\, i sota el títol “Fem visibles les forces cel·lulars”\, el Professor Xavier Trepat explicarà com i perquè estudien les forces que fan les cèl·lules. \nA més a més\, per celebrar que aquest any és l’Any Internacional de la llum\, finalitzarem la visita amb un brindis i un petit concert amb inspiració científica.\nAquesta activitat és gratuïta\, està dirigida a majos de 16 anys i les places són limitades\, per tant cal INSCRIURE’S URL:https://ibecbarcelona.eu/event/setmana-de-la-ciencia-2015/ LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain CATEGORIES:Outreach / Fair / Festival END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151111T110000 DTEND;TZID=UTC:20151111T130000 DTSTAMP:20260426T132616 CREATED:20151021T082429Z LAST-MODIFIED:20151021T082429Z UID:19399-1447239600-1447246800@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Rosa Letizia Zaffino DESCRIPTION:“Development of a nano-sensor for the direct electrical free-label detection of DNA’s hybridisation and single nucleotide polymorphism”\nRosa Letizia Zaffino\, Nanobioengineering group\nRosa will be defending her PhD thesis on Wednesday 11th November at 11:00 in the Sala de Grados (A01S)\, Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-rosa-letizia-zaffino/ LOCATION:Sala de Grados (A01S)\, Faculty of Physics\, UB\, Barcelona CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151111T110000 DTEND;TZID=UTC:20151111T130000 DTSTAMP:20260426T132616 CREATED:20151021T082429Z LAST-MODIFIED:20151021T082429Z UID:95873-1447239600-1447246800@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Rosa Letizia Zaffino DESCRIPTION:“Development of a nano-sensor for the direct electrical free-label detection of DNA’s hybridisation and single nucleotide polymorphism”\nRosa Letizia Zaffino\, Nanobioengineering group\nRosa will be defending her PhD thesis on Wednesday 11th November at 11:00 in the Sala de Grados (A01S)\, Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-rosa-letizia-zaffino-2/ LOCATION:Sala de Grados (A01S)\, Faculty of Physics\, UB\, Barcelona CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151027T113000 DTEND;TZID=UTC:20151027T133000 DTSTAMP:20260426T132616 CREATED:20151021T064210Z LAST-MODIFIED:20151021T064210Z UID:19388-1445945400-1445952600@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Andrés Arcentales Viteri DESCRIPTION:“Análisis de la interacción cardíaca y respiratoria en pacientes con cardiomiopatía y pacientes en proceso de extubación”\nAndrés Arcentales Viteri\, Biomedical Signal Processing and Interpretation group\nAndrés will be defending his PhD thesis on Tuesday 27th October at 11:30 in the Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-andres-arcentales-viteri/ LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028 CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151027T113000 DTEND;TZID=UTC:20151027T133000 DTSTAMP:20260426T132616 CREATED:20151021T064210Z LAST-MODIFIED:20151021T064210Z UID:95872-1445945400-1445952600@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Andrés Arcentales Viteri DESCRIPTION:“Análisis de la interacción cardíaca y respiratoria en pacientes con cardiomiopatía y pacientes en proceso de extubación”\nAndrés Arcentales Viteri\, Biomedical Signal Processing and Interpretation group\nAndrés will be defending his PhD thesis on Tuesday 27th October at 11:30 in the Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-andres-arcentales-viteri-2/ LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028 CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20151023T100000 DTEND;TZID=Europe/Madrid:20151023T110000 DTSTAMP:20260426T132616 CREATED:20150803T123423Z LAST-MODIFIED:20150803T123423Z UID:18434-1445594400-1445598000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Miquel Bosch Pita DESCRIPTION:The molecular mechanisms of memory persistence: imaging how single synapses learn in real time\nMiquel Bosch Pita\, Nanoprobes and nanoswitches group\, IBEC\nMemories are stored in our brain through the ability of synaptic connections to modify their structure and function in a long-lasting way. However\, nobody has ever observed how these changes occur in a single synapse in real time.\nI will explain how we used a new combination of optical technologies to reveal the molecular remodeling that takes place inside a synapse during the creation of a memory. We used two-photon microscopy to stimulate individual synapses and to visualize protein trafficking in real time. We identified a unique protein that is rapidly and persistently captured in potentiated synapses\, forming a new macromolecule that could serve as a memory tag. We developed a novel photo-marking technique that allowed us to localize the same synapses under both two-photon and electron microscopies. This way we observed how different synaptic structures evolve asynchronously in three temporal phases during synaptic potentiation. URL:https://ibecbarcelona.eu/event/ibec-seminar-miquel-bosch-pita/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20151023T100000 DTEND;TZID=Europe/Madrid:20151023T110000 DTSTAMP:20260426T132616 CREATED:20150803T123423Z LAST-MODIFIED:20150803T123423Z UID:95866-1445594400-1445598000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Miquel Bosch Pita DESCRIPTION:The molecular mechanisms of memory persistence: imaging how single synapses learn in real time\nMiquel Bosch Pita\, Nanoprobes and nanoswitches group\, IBEC\nMemories are stored in our brain through the ability of synaptic connections to modify their structure and function in a long-lasting way. However\, nobody has ever observed how these changes occur in a single synapse in real time.\nI will explain how we used a new combination of optical technologies to reveal the molecular remodeling that takes place inside a synapse during the creation of a memory. We used two-photon microscopy to stimulate individual synapses and to visualize protein trafficking in real time. We identified a unique protein that is rapidly and persistently captured in potentiated synapses\, forming a new macromolecule that could serve as a memory tag. We developed a novel photo-marking technique that allowed us to localize the same synapses under both two-photon and electron microscopies. This way we observed how different synaptic structures evolve asynchronously in three temporal phases during synaptic potentiation. URL:https://ibecbarcelona.eu/event/ibec-seminar-miquel-bosch-pita-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151022T110000 DTEND;TZID=UTC:20151022T120000 DTSTAMP:20260426T132616 CREATED:20151013T090618Z LAST-MODIFIED:20170801T131050Z UID:19216-1445511600-1445515200@ibecbarcelona.eu SUMMARY:Nanomalaria joint unit seminar: Konstantinos Mitsakakis\, University of Freiburg DESCRIPTION:LabDisk\, a multi-purpose\, multi-target diagnostic platform for patient management and surveillance at the point-of-care\nDr. Konstantinos Mitsakakis\, Hahn-Schickard & IMTEK\, Department of Microsystems Engineering\, University of Freiburg\, Germany\nThe LabDisk is a CD-shaped microfluidic platform with all reagents integrated for on-site sample-to-answer diagnosis of single or multiple infectious diseases stemming from parasites\, bacteria\, viruses\, or co-infections of theirs. Through “composite” diagnosis\, by combining molecular diagnostics and protein biomarker detection\, the LabDisk offers increased reliability in pathogen species identification. Its modular nature enables the creation of a “disc library” for different sample matrices\, and the rapid adaptation to end-users’ requests (endemic needs\, sudden epidemics outbreaks). \nThe presentation will consist of two sections: (1) description of the LabDisk and its operating principle (modularity\, multiplexity\, fully integrated sample preparation); and (2) an overview of the current infectious disease-related applications\, in particular: neonatal sepsis\, respiratory tract infections\, antibiotic resistance\, febrile tropical infections (malaria\, dengue\, pneumonia\, typhoid)\, mosquito/vector control. \nDr. Mitsakakis has been invited by Xavier Fernàndez Busquets\, Head of Nanomalaria Joint Unit URL:https://ibecbarcelona.eu/event/ibec-external-seminar-konstantinos-mitsakakis-university-of-freiburg/ LOCATION:Aula 6\, Faculty of Medicine\, Carrer de Casanova\, 143\, Barcelona CATEGORIES:Joint seminar / workshop / symposium END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151022T110000 DTEND;TZID=UTC:20151022T120000 DTSTAMP:20260426T132616 CREATED:20151013T090618Z LAST-MODIFIED:20151013T090618Z UID:95870-1445511600-1445515200@ibecbarcelona.eu SUMMARY:Nanomalaria joint unit seminar: Konstantinos Mitsakakis\, University of Freiburg DESCRIPTION:LabDisk\, a multi-purpose\, multi-target diagnostic platform for patient management and surveillance at the point-of-care\nDr. Konstantinos Mitsakakis\, Hahn-Schickard & IMTEK\, Department of Microsystems Engineering\, University of Freiburg\, Germany\nThe LabDisk is a CD-shaped microfluidic platform with all reagents integrated for on-site sample-to-answer diagnosis of single or multiple infectious diseases stemming from parasites\, bacteria\, viruses\, or co-infections of theirs. Through “composite” diagnosis\, by combining molecular diagnostics and protein biomarker detection\, the LabDisk offers increased reliability in pathogen species identification. Its modular nature enables the creation of a “disc library” for different sample matrices\, and the rapid adaptation to end-users’ requests (endemic needs\, sudden epidemics outbreaks). \nThe presentation will consist of two sections: (1) description of the LabDisk and its operating principle (modularity\, multiplexity\, fully integrated sample preparation); and (2) an overview of the current infectious disease-related applications\, in particular: neonatal sepsis\, respiratory tract infections\, antibiotic resistance\, febrile tropical infections (malaria\, dengue\, pneumonia\, typhoid)\, mosquito/vector control. \nDr. Mitsakakis has been invited by Xavier Fernàndez Busquets\, Head of Nanomalaria Joint Unit URL:https://ibecbarcelona.eu/event/ibec-external-seminar-konstantinos-mitsakakis-university-of-freiburg-2/ LOCATION:Aula 6\, Faculty of Medicine\, Carrer de Casanova\, 143\, Barcelona CATEGORIES:Joint seminar / workshop / symposium END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151021T113000 DTEND;TZID=UTC:20151021T133000 DTSTAMP:20260426T132616 CREATED:20151015T111927Z LAST-MODIFIED:20151015T111927Z UID:95871-1445427000-1445434200@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Ana Guaman DESCRIPTION:“Multivariate Signal Processing for Quantitative and Qualitative analysis of Ion Mobility Spectrometry applied to Biomedical and Food Applications”\n \nAna Guaman\, Signal and information processing for sensing systems group\nAna will be defending her PhD thesis on Wednesday 21st October at 11:30 in the Sala de grados\, Facultad de Física\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-ana-guaman-2/ LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028 CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151021T113000 DTEND;TZID=UTC:20151021T133000 DTSTAMP:20260426T132616 CREATED:20151015T111927Z LAST-MODIFIED:20151015T111927Z UID:19304-1445427000-1445434200@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Ana Guaman DESCRIPTION:“Multivariate Signal Processing for Quantitative and Qualitative analysis of Ion Mobility Spectrometry applied to Biomedical and Food Applications”\n \nAna Guaman\, Signal and information processing for sensing systems group\nAna will be defending her PhD thesis on Wednesday 21st October at 11:30 in the Sala de grados\, Facultad de Física\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-ana-guaman/ LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028 CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151019T100000 DTEND;TZID=UTC:20151019T120000 DTSTAMP:20260426T132616 CREATED:20151006T054804Z LAST-MODIFIED:20151006T054804Z UID:19129-1445248800-1445256000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Cell Imaging Day - Molecular Probes DESCRIPTION:Cell Imaging Day – Molecular Probes\nClara Streiff\, Senior Technical Specialist · Molecular Probes – ThermoFisher Scientific\nSeminar:\n• Marcaje de estructuras celulares en células vivas (Bacmam Cellight)\n• Proliferación celular (Click-iT® EdU)\n• Estrés oxidativo (CellROX®)\n• Fagocitosis (PHrodo)\n• Apoptosis (Cellevent Caspase 3 and 7)\n• Mejorando la señal fluorescente en células vivas y fijadas (ReadyProbes reactivos “ready to use”)\n• Ventajas de la citometría por focalización acústica (Attune®NxT acoustic focusing cytometer) \nAl final del seminario podrás pasar tus muestras en el microscopio EVOS® FL AUTO y prueba nuestros reactivos ReadyProbes de Molecular Probes sin compromiso\, reactivos para imaging que permiten marcar tus células sin necesidad de hacer calculos\, diluciones ni pipetear. URL:https://ibecbarcelona.eu/event/ibec-seminar-cell-imaging-day-molecular-probes/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=UTC:20151019T100000 DTEND;TZID=UTC:20151019T120000 DTSTAMP:20260426T132616 CREATED:20151006T054804Z LAST-MODIFIED:20151006T054804Z UID:95869-1445248800-1445256000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Cell Imaging Day - Molecular Probes DESCRIPTION:Cell Imaging Day – Molecular Probes\nClara Streiff\, Senior Technical Specialist · Molecular Probes – ThermoFisher Scientific\nSeminar:\n• Marcaje de estructuras celulares en células vivas (Bacmam Cellight)\n• Proliferación celular (Click-iT® EdU)\n• Estrés oxidativo (CellROX®)\n• Fagocitosis (PHrodo)\n• Apoptosis (Cellevent Caspase 3 and 7)\n• Mejorando la señal fluorescente en células vivas y fijadas (ReadyProbes reactivos “ready to use”)\n• Ventajas de la citometría por focalización acústica (Attune®NxT acoustic focusing cytometer) \nAl final del seminario podrás pasar tus muestras en el microscopio EVOS® FL AUTO y prueba nuestros reactivos ReadyProbes de Molecular Probes sin compromiso\, reactivos para imaging que permiten marcar tus células sin necesidad de hacer calculos\, diluciones ni pipetear. URL:https://ibecbarcelona.eu/event/ibec-seminar-cell-imaging-day-molecular-probes-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20151016T100000 DTEND;TZID=Europe/Madrid:20151016T110000 DTSTAMP:20260426T132616 CREATED:20150713T060412Z LAST-MODIFIED:20150713T060412Z UID:18096-1444989600-1444993200@ibecbarcelona.eu SUMMARY:IBEC Seminar: Lorenzo Albertazzi DESCRIPTION:Nanoscopy for Nanomedicine: looking at nanomaterials in action one molecule at a time\nLorenzo Albertazzi\, IBEC\nThe use of nanomaterials for biomedical purposes such as drug or gene delivery is one of the key applications of nanotechnology. In this framework a variety of materials have been fabricated\, evaluated in cells and in vivo and\, in some cases\, successfully translated into clinical applications. A crucial factor limiting the design of effective nanocarriers is the lack of knowledge about materials-cell interactions that severely limit the rational design of nanosized devices.\nHere I’ll show how advanced optical microscopy techniques can shine a light on nanomaterials behavior in the biological environment\, helping us to understand structure-activity relationships and to design improved and more effective therapeutic devices. In particular I’ll discuss the ability of super resolution microscopy to image with nanometric resolution nanomaterials interactions with target cells. The potential and the applications of the technique will be discussed\, with particular emphasis on the study of self-assembled bio-inspired materials. URL:https://ibecbarcelona.eu/event/ibec-seminar-lorenzo-albertazzi/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20151016T100000 DTEND;TZID=Europe/Madrid:20151016T110000 DTSTAMP:20260426T132616 CREATED:20150713T060412Z LAST-MODIFIED:20150713T060412Z UID:95862-1444989600-1444993200@ibecbarcelona.eu SUMMARY:IBEC Seminar: Lorenzo Albertazzi DESCRIPTION:Nanoscopy for Nanomedicine: looking at nanomaterials in action one molecule at a time\nLorenzo Albertazzi\, IBEC\nThe use of nanomaterials for biomedical purposes such as drug or gene delivery is one of the key applications of nanotechnology. In this framework a variety of materials have been fabricated\, evaluated in cells and in vivo and\, in some cases\, successfully translated into clinical applications. A crucial factor limiting the design of effective nanocarriers is the lack of knowledge about materials-cell interactions that severely limit the rational design of nanosized devices.\nHere I’ll show how advanced optical microscopy techniques can shine a light on nanomaterials behavior in the biological environment\, helping us to understand structure-activity relationships and to design improved and more effective therapeutic devices. In particular I’ll discuss the ability of super resolution microscopy to image with nanometric resolution nanomaterials interactions with target cells. The potential and the applications of the technique will be discussed\, with particular emphasis on the study of self-assembled bio-inspired materials. URL:https://ibecbarcelona.eu/event/ibec-seminar-lorenzo-albertazzi-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20151001T090000 DTEND;TZID=Europe/Madrid:20151002T123000 DTSTAMP:20260426T132616 CREATED:20150901T133610Z LAST-MODIFIED:20170801T131104Z UID:18643-1443690000-1443789000@ibecbarcelona.eu SUMMARY:B·Debate: Future Tools for Biomedical Research: in vitro\, in silico and in vivo disease modeling DESCRIPTION:The increasing costs of biomedical research and drug discovery and the continually rising numbers of compound failures provoke an urgent need for novel tools for basic research and preclinical testing of drugs. \nThe cross-breeding of nanotechnologies\, life and computational sciences is harnessing enabling technologies for drug discovery\, development\, toxicity testing and disease modeling. These advances can move in vitro cell and tissue cultures beyond the current state-of-the-art\, which poorly reflect patient physiology\, and create “in vivo human-like” platforms that allow cheaper and efficient drug and toxicity assays. \nAt the same time\, important efforts are being made to create improved animal and computational models to better mimic human physiology in health and disease. \nUnder this framework\, the B·Debate “Future Tools for Biomedical Research: In Vitro\, In Silico and In Vivo Disease Modeling”\, coorganized by B·Debate and  IBEC\, is an opportunity to debate with experts and professionals of the field to review experiences and best practices and to identify and address barriers in the development and adoption of advanced methods for disease modeling\, with a potential to revolutionize preclinical research in particular\, and the validation and commercialization of new therapies and diagnostics at large. \nVisit the website for more details. URL:https://ibecbarcelona.eu/event/b%c2%b7debate-future-tools-for-biomedical-research-in-vitro-in-silico-and-in-vivo-disease-modeling/ LOCATION:CosmoCaixa Barcelona\, Carrer d'Isaac Newton\, 08022 Barcelona\, Spain CATEGORIES:IBEC Symposium / Conference / Congress / Workshop END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20151001T090000 DTEND;TZID=Europe/Madrid:20151002T123000 DTSTAMP:20260426T132616 CREATED:20150901T133610Z LAST-MODIFIED:20150901T133610Z UID:95867-1443690000-1443789000@ibecbarcelona.eu SUMMARY:B·Debate: Future Tools for Biomedical Research: in vitro\, in silico and in vivo disease modeling DESCRIPTION:The increasing costs of biomedical research and drug discovery and the continually rising numbers of compound failures provoke an urgent need for novel tools for basic research and preclinical testing of drugs. \nThe cross-breeding of nanotechnologies\, life and computational sciences is harnessing enabling technologies for drug discovery\, development\, toxicity testing and disease modeling. These advances can move in vitro cell and tissue cultures beyond the current state-of-the-art\, which poorly reflect patient physiology\, and create “in vivo human-like” platforms that allow cheaper and efficient drug and toxicity assays. \nAt the same time\, important efforts are being made to create improved animal and computational models to better mimic human physiology in health and disease. \nUnder this framework\, the B·Debate “Future Tools for Biomedical Research: In Vitro\, In Silico and In Vivo Disease Modeling”\, coorganized by B·Debate and  IBEC\, is an opportunity to debate with experts and professionals of the field to review experiences and best practices and to identify and address barriers in the development and adoption of advanced methods for disease modeling\, with a potential to revolutionize preclinical research in particular\, and the validation and commercialization of new therapies and diagnostics at large. \nVisit the website for more details. URL:https://ibecbarcelona.eu/event/b%c2%b7debate-future-tools-for-biomedical-research-in-vitro-in-silico-and-in-vivo-disease-modeling-2/ LOCATION:CosmoCaixa Barcelona\, Carrer d'Isaac Newton\, 08022 Barcelona\, Spain CATEGORIES:IBEC Symposium / Conference / Congress / Workshop END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150930T080000 DTEND;TZID=Europe/Madrid:20150930T180000 DTSTAMP:20260426T132616 CREATED:20150629T071347Z LAST-MODIFIED:20150803T123238Z UID:17665-1443600000-1443636000@ibecbarcelona.eu SUMMARY:8th IBEC Symposium DESCRIPTION:8th IBEC Symposium: Bioengineering for Regenerative Therapies\nWednesday 30th September 2015\nPlease save the date for the 8th IBEC Symposium on Bioengineering for Regenerative Therapies\, which will take place on Wednesday 30th September 2015. \nThis year\, the IBEC Symposium will focus on one of our three areas of applications for bioengineering\, Regenerative Therapies\, and will bring together high-profile international experts in our fields of expertise. It provides an open forum for interdisciplinary discussions and networking\, benefitting young researchers and established scientists alike. \nConfirmed speakers this year include:\nGiorgio Scita\, Associate Professor of General Pathology at the Department of Health Sciences\, University of Milan.\nManuel Salmeron\, Chair of Biomedical Engineering\, University of Glasgow\nRon Mckay\, Director for Basic Sciences\, Lieber Institute for Brain Development\, Baltimore\nJosep Samitier\, IBEC \nEveryone is welcome to submit abstracts for the posters and flash presentations sessions by Thursday 16th July 2015. Please use this template. \nWe look forward to welcoming you to our symposium in September.\n  \nUseful dates:\nDeadline for abstracts: 16th July 2015\nNotification of acceptance: 8th September 2015\nhttps://ibecbarcelona.eu/events/Symposium2015 URL:https://ibecbarcelona.eu/event/8th-ibec-symposium/ LOCATION:AXA Auditorium\, L'illa Diagonal\, Av. Diagonal 547 \, Barcelona\, 08029 CATEGORIES:IBEC Symposium / Conference / Congress / Workshop END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150930T080000 DTEND;TZID=Europe/Madrid:20150930T180000 DTSTAMP:20260426T132616 CREATED:20150629T071347Z LAST-MODIFIED:20150629T071347Z UID:95858-1443600000-1443636000@ibecbarcelona.eu SUMMARY:8th IBEC Symposium DESCRIPTION:8th IBEC Symposium: Bioengineering for Regenerative Therapies\nWednesday 30th September 2015\nPlease save the date for the 8th IBEC Symposium on Bioengineering for Regenerative Therapies\, which will take place on Wednesday 30th September 2015. \nThis year\, the IBEC Symposium will focus on one of our three areas of applications for bioengineering\, Regenerative Therapies\, and will bring together high-profile international experts in our fields of expertise. It provides an open forum for interdisciplinary discussions and networking\, benefitting young researchers and established scientists alike. \nConfirmed speakers this year include:\nGiorgio Scita\, Associate Professor of General Pathology at the Department of Health Sciences\, University of Milan.\nManuel Salmeron\, Chair of Biomedical Engineering\, University of Glasgow\nRon Mckay\, Director for Basic Sciences\, Lieber Institute for Brain Development\, Baltimore\nJosep Samitier\, IBEC \nEveryone is welcome to submit abstracts for the posters and flash presentations sessions by Thursday 16th July 2015. Please use this template. \nWe look forward to welcoming you to our symposium in September.\n  \nUseful dates:\nDeadline for abstracts: 16th July 2015\nNotification of acceptance: 8th September 2015\nhttp://ibecbarcelona.eu/events/Symposium2015 URL:https://ibecbarcelona.eu/event/8th-ibec-symposium-2/ LOCATION:AXA Auditorium\, L'illa Diagonal\, Av. Diagonal 547 \, Barcelona\, 08029 CATEGORIES:IBEC Symposium / Conference / Congress / Workshop END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150922T000000 DTEND;TZID=Europe/Madrid:20150922T130000 DTSTAMP:20260426T132616 CREATED:20150918T102346Z LAST-MODIFIED:20150918T102346Z UID:18953-1442880000-1442926800@ibecbarcelona.eu SUMMARY:IBEC Seminar: Albert Folch DESCRIPTION:Print-and-Play Microfluidics\nAlbert Folch\, Associate Professor\, University of Washington\nBiologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore\, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography\, a form of 3D printing\, in order to make microfluidic technology readily available via the web to biomedical scientists. Our lab presently focuses on developing 3D-printable microdevices that facilitate the advancement of basic neuroscience and translational cancer applications. The lab’s long-term mission is to make microfluidic devices as easy to use as smartphones and make them easily available to clinicians in order to enable novel cancer diagnostics and therapies. URL:https://ibecbarcelona.eu/event/ibec-seminar-albert-folch/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150922T000000 DTEND;TZID=Europe/Madrid:20150922T130000 DTSTAMP:20260426T132616 CREATED:20150918T102346Z LAST-MODIFIED:20150918T102346Z UID:95868-1442880000-1442926800@ibecbarcelona.eu SUMMARY:IBEC Seminar: Albert Folch DESCRIPTION:Print-and-Play Microfluidics\nAlbert Folch\, Associate Professor\, University of Washington\nBiologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore\, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography\, a form of 3D printing\, in order to make microfluidic technology readily available via the web to biomedical scientists. Our lab presently focuses on developing 3D-printable microdevices that facilitate the advancement of basic neuroscience and translational cancer applications. The lab’s long-term mission is to make microfluidic devices as easy to use as smartphones and make them easily available to clinicians in order to enable novel cancer diagnostics and therapies. URL:https://ibecbarcelona.eu/event/ibec-seminar-albert-folch-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150918T100000 DTEND;TZID=Europe/Madrid:20150918T110000 DTSTAMP:20260426T132616 CREATED:20150629T072320Z LAST-MODIFIED:20150629T072320Z UID:17667-1442570400-1442574000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Marc Martí-Renom DESCRIPTION:Structure determination of genomes and genomic domains by satisfaction of spatial restraints\nMarc Martí-Renom\, ICREA Research Professor / CNAG / CRG\nThe genome three-dimensional (3D) organization plays important\, yet poorly understood roles in gene regulation. Chromosomes assume multiple distinct conformations in relation to the expression status of resident genes and undergo dramatic alterations in higher order structure through the cell cycle. Despite advances in microscopy\, a general technique to determine the 3D conformation of chromatin has been lacking. We developed a new method for the determination of the 3D conformation of chromatin domains in the interphase nucleus\, which combines 3C-based experiments with the computational Integrative Modeling Platform (IMP). The general approach of our method\, which has been applied to study the 3D conformation of the alpha-globin domain in the human genome [1]\, the Caulobacter crescentus whole genome [2]\, and the dynamic response of Topologically Associating Domains (TADs) to hormone treatment in breast cancer cell lines [3]\, opens the field for comprehensive studies of the 3D conformation of chromosomal domains and contributes to a more complete characterization of genome regulation.\n[1] D. Baù et al. Nat Struct Mol Biol (2011) 18:107.\n[2] M.A. Umbarger\, et al. Molecular Cell (2011) 44:252\n[3] Le Dily\, et al. Genes & Dev (2014) 28:2151 URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-marti-renom/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150918T100000 DTEND;TZID=Europe/Madrid:20150918T110000 DTSTAMP:20260426T132616 CREATED:20150629T072320Z LAST-MODIFIED:20150629T072320Z UID:95859-1442570400-1442574000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Marc Martí-Renom DESCRIPTION:Structure determination of genomes and genomic domains by satisfaction of spatial restraints\nMarc Martí-Renom\, ICREA Research Professor / CNAG / CRG\nThe genome three-dimensional (3D) organization plays important\, yet poorly understood roles in gene regulation. Chromosomes assume multiple distinct conformations in relation to the expression status of resident genes and undergo dramatic alterations in higher order structure through the cell cycle. Despite advances in microscopy\, a general technique to determine the 3D conformation of chromatin has been lacking. We developed a new method for the determination of the 3D conformation of chromatin domains in the interphase nucleus\, which combines 3C-based experiments with the computational Integrative Modeling Platform (IMP). The general approach of our method\, which has been applied to study the 3D conformation of the alpha-globin domain in the human genome [1]\, the Caulobacter crescentus whole genome [2]\, and the dynamic response of Topologically Associating Domains (TADs) to hormone treatment in breast cancer cell lines [3]\, opens the field for comprehensive studies of the 3D conformation of chromosomal domains and contributes to a more complete characterization of genome regulation.\n[1] D. Baù et al. Nat Struct Mol Biol (2011) 18:107.\n[2] M.A. Umbarger\, et al. Molecular Cell (2011) 44:252\n[3] Le Dily\, et al. Genes & Dev (2014) 28:2151 URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-marti-renom-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150917T100000 DTEND;TZID=Europe/Madrid:20150917T110000 DTSTAMP:20260426T132616 CREATED:20150803T122810Z LAST-MODIFIED:20150803T122810Z UID:95865-1442484000-1442487600@ibecbarcelona.eu SUMMARY:IBEC Seminar: Richard Reilly DESCRIPTION:All a question of Timing: Sensory processing in Dystonia and Parkinson’s Disease\nProfessor Richard Reilly\, Trinity Centre for Bioengineering · Trinity College Dublin\nThere are many challenges in the diagnosis and management of neurological disorders. Neural Engineering can help address some of these by the development of novel engineering\, computational and experimental methods to help understand the pathogenesis of neurological disorders. This talk will detail results from recent neural engineering studies into understanding cervical dystonia and Parkinson’s disease. \nWhile the pathogenesis of cervical dystonia remains unknown\, recent animal and clinical experimental studies have indicated its probable mechanisms. Human movement involves a complex series of coordinated musculoskeletal but also neural processes. A breakdown in any of these processes can result in irregular movement. The temporal discrimination threshold is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. Studies in our group and that of others have shown that abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid inhibition\, resulting from\, in turn\, from as yet undetermined\, genetic mutations. Such disinhibition is a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus\, b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective gamma-aminobutyric acid activity both within the superior colliculus and from the substantia nigra pars reticulata. This talk will review some our recent experiments addressing this hypothesis. \nSensory and perceptual disturbances are common in Parkinson’s disease. Subtle deficits of the sensory system\, often not detected by routine examination\, occur in people with Parkinson’s disease. From simple anosmia and impaired kinesthetic perception\, to more complex visual hallucinations and spatiotemporal perceptual abnormalities\, altered sensory processing is found across multiple modalities. Of note\, integration of multiple environmental sensory inputs is crucial for a refined but complex goal-directed motor output (e.g. locomotion through a crowded environment). There is increasing evidence that these sensory deficits contribute to the pathophysiology of some of the abnormal motor features of Parkinson’s disease. This talk will review some of our recent experiments to probe multisensory deficits in Parkinson’s disease and introduce one intervention developed around sensory and cognitive processing. URL:https://ibecbarcelona.eu/event/ibec-seminar-richard-reilly-2/ CATEGORIES:IBEC Seminar END:VEVENT END:VCALENDAR