BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Institute for Bioengineering of Catalonia X-ORIGINAL-URL:https://ibecbarcelona.eu X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Madrid BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20140330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20141026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20150329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20151025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20160327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20161030T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150917T100000 DTEND;TZID=Europe/Madrid:20150917T110000 DTSTAMP:20260426T174500 CREATED:20150803T122810Z LAST-MODIFIED:20150803T122810Z UID:18430-1442484000-1442487600@ibecbarcelona.eu SUMMARY:IBEC Seminar: Richard Reilly DESCRIPTION:All a question of Timing: Sensory processing in Dystonia and Parkinson’s Disease\nProfessor Richard Reilly\, Trinity Centre for Bioengineering · Trinity College Dublin\nThere are many challenges in the diagnosis and management of neurological disorders. Neural Engineering can help address some of these by the development of novel engineering\, computational and experimental methods to help understand the pathogenesis of neurological disorders. This talk will detail results from recent neural engineering studies into understanding cervical dystonia and Parkinson’s disease. \nWhile the pathogenesis of cervical dystonia remains unknown\, recent animal and clinical experimental studies have indicated its probable mechanisms. Human movement involves a complex series of coordinated musculoskeletal but also neural processes. A breakdown in any of these processes can result in irregular movement. The temporal discrimination threshold is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. Studies in our group and that of others have shown that abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid inhibition\, resulting from\, in turn\, from as yet undetermined\, genetic mutations. Such disinhibition is a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus\, b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective gamma-aminobutyric acid activity both within the superior colliculus and from the substantia nigra pars reticulata. This talk will review some our recent experiments addressing this hypothesis. \nSensory and perceptual disturbances are common in Parkinson’s disease. Subtle deficits of the sensory system\, often not detected by routine examination\, occur in people with Parkinson’s disease. From simple anosmia and impaired kinesthetic perception\, to more complex visual hallucinations and spatiotemporal perceptual abnormalities\, altered sensory processing is found across multiple modalities. Of note\, integration of multiple environmental sensory inputs is crucial for a refined but complex goal-directed motor output (e.g. locomotion through a crowded environment). There is increasing evidence that these sensory deficits contribute to the pathophysiology of some of the abnormal motor features of Parkinson’s disease. This talk will review some of our recent experiments to probe multisensory deficits in Parkinson’s disease and introduce one intervention developed around sensory and cognitive processing. URL:https://ibecbarcelona.eu/event/ibec-seminar-richard-reilly/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150724T100000 DTEND;TZID=Europe/Madrid:20150724T110000 DTSTAMP:20260426T174500 CREATED:20150720T092247Z LAST-MODIFIED:20150720T102616Z UID:18148-1437732000-1437735600@ibecbarcelona.eu SUMMARY:IBEC Seminar: Dr. François St. Pierre DESCRIPTION:Imaging electrical activity in vivo with ultrafast protein sensors \nDr. François St. Pierre\, Department of Neuroscience\, Baylor College of Medicine / \nDepartment of Electrical and Computer Engineering\, Rice University\nImaging of rapid brain electrical activity has been on the wish list of neurobiologists for many years and has received renewed attention with the launch of the BRAIN initiative by the White House in the U.S.A. In particular\, neuroscientists have long sought voltage sensors based on proteins to reveal brain activity in genetically defined neuronal circuits. I will present novel protein voltage sensors that leverage optimized parts and creative new designs to report neural activity with unprecedented temporal resolution in vitro\, in brain slices and in vivo. Importantly\, these synthetic sensors report neural activity at the millisecond timescale over which key information processing functions are thought to take place. I will show how these new optical tools enable us to follow neural information processing in the fly visual system with subcellular resolution. I will also present our recent success at monitoring spontaneous electrical activity in stem cell-derived cardiomyocytes. URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-francois-st-pierre/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150724T100000 DTEND;TZID=Europe/Madrid:20150724T110000 DTSTAMP:20260426T174500 CREATED:20150720T092247Z LAST-MODIFIED:20150720T092247Z UID:95864-1437732000-1437735600@ibecbarcelona.eu SUMMARY:IBEC Seminar: Dr. François St. Pierre DESCRIPTION:Imaging electrical activity in vivo with ultrafast protein sensors \nDr. François St. Pierre\, Department of Neuroscience\, Baylor College of Medicine / \nDepartment of Electrical and Computer Engineering\, Rice University\nImaging of rapid brain electrical activity has been on the wish list of neurobiologists for many years and has received renewed attention with the launch of the BRAIN initiative by the White House in the U.S.A. In particular\, neuroscientists have long sought voltage sensors based on proteins to reveal brain activity in genetically defined neuronal circuits. I will present novel protein voltage sensors that leverage optimized parts and creative new designs to report neural activity with unprecedented temporal resolution in vitro\, in brain slices and in vivo. Importantly\, these synthetic sensors report neural activity at the millisecond timescale over which key information processing functions are thought to take place. I will show how these new optical tools enable us to follow neural information processing in the fly visual system with subcellular resolution. I will also present our recent success at monitoring spontaneous electrical activity in stem cell-derived cardiomyocytes. URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-francois-st-pierre-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150721T110000 DTEND;TZID=Europe/Madrid:20150721T130000 DTSTAMP:20260426T174500 CREATED:20150714T085454Z LAST-MODIFIED:20150714T085454Z UID:95863-1437476400-1437483600@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Erola Pairo DESCRIPTION:“Detection of transcription factor binding sites by multivariate signal processing”\n \nErola Pairo\, Signal and information processing for sensing systems group\nErola will be defending her PhD thesis on Tuesday 21st July at 11:00 in the Eduard Fontsere room at the Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-erola-pairo-2/ LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028 CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150721T110000 DTEND;TZID=Europe/Madrid:20150721T130000 DTSTAMP:20260426T174500 CREATED:20150714T085454Z LAST-MODIFIED:20150714T085823Z UID:18116-1437476400-1437483600@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Erola Pairo DESCRIPTION:“Detection of transcription factor binding sites by multivariate signal processing”\n \nErola Pairo\, Signal and information processing for sensing systems group\nErola will be defending her PhD thesis on Tuesday 21st July at 11:00 in the Eduard Fontsere room at the Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-erola-pairo/ LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028 CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150717T150000 DTEND;TZID=Europe/Madrid:20150717T170000 DTSTAMP:20260426T174500 CREATED:20150713T053848Z LAST-MODIFIED:20150713T053848Z UID:95861-1437145200-1437152400@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Carlos Ruiz DESCRIPTION:“A computational study of intervertebral disc degeneration in relation to changes in regional tissue composition and disc nutrition”\n \nCarlos Ruiz Wills\, Biomechanics & Mechanobiology group\nCarles will be defending his PhD thesis on Friday 17th July at 15:00 in the Aula Capella\, Facultad de Ingeniería Industrial (ETSEIB)\, Av. Diagonal 647. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-carlos-ruiz-2/ LOCATION:Aula Capella\, Facultad de Ingeniería Industrial (ETSEIB)\, Av. Diagonal 647\, Barcelona\, Spain CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150717T150000 DTEND;TZID=Europe/Madrid:20150717T170000 DTSTAMP:20260426T174500 CREATED:20150713T053848Z LAST-MODIFIED:20150714T085909Z UID:18094-1437145200-1437152400@ibecbarcelona.eu SUMMARY:PhD Thesis Defense: Carlos Ruiz DESCRIPTION:“A computational study of intervertebral disc degeneration in relation to changes in regional tissue composition and disc nutrition”\n \nCarlos Ruiz Wills\, Biomechanics & Mechanobiology group\nCarles will be defending his PhD thesis on Friday 17th July at 15:00 in the Aula Capella\, Facultad de Ingeniería Industrial (ETSEIB)\, Av. Diagonal 647. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu URL:https://ibecbarcelona.eu/event/phd-thesis-defense-carlos-ruiz/ LOCATION:Aula Capella\, Facultad de Ingeniería Industrial (ETSEIB)\, Av. Diagonal 647\, Barcelona\, Spain CATEGORIES:PhD Thesis Defence END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150710T100000 DTEND;TZID=Europe/Madrid:20150710T110000 DTSTAMP:20260426T174500 CREATED:20150527T073448Z LAST-MODIFIED:20150527T073448Z UID:16868-1436522400-1436526000@ibecbarcelona.eu SUMMARY:PhD Discussions Session: Verónica Hortigüela & Anna Crespo DESCRIPTION:Developing a platform for receptor clustering studies\nVerónica Hortigüela\, Biomimetic systems for cell engineering group\nReceptors are signaling units that usually require interactions and associations with other molecules in complexes to trigger a signaling pathway. This process is known as receptor clustering and comes typically along with a simultaneous ligand clustering underneath the cell membrane. We have developed a strategy to precisely control the ligand distribution on a substrate at the nanoscale to study in detail receptor clustering processes. Herein we present a tunable platform based on self-assembled di-block copolymers that tend to segregate into nanostructures. Di-block copolymers are confined to a thin film providing a template for ligand patterning. \n  \nRibonucleotide Reductase anaerobic enzymes are essential for biofilm formation of Pseudomonas aeruginosa\nAnna Crespo\, Bacterial infections: antimicrobial therapies group\nMost chronic infections in humans are caused by communities of microorganisms living in organized structures\, known as biofilms. Biofilm-related infections\, such as pneumonia (in patients suffering for cystic fibrosis or chronic obstructive pulmonary disease –COPD-) and catheter-associated infections\, affect millions of people in the developed world. \nCell clusters in biofilms are characterized by presenting\, in its extracellular polymeric matrix\, gradients of oxygen\, nutrients and metabolic waste products. The so-formed chemical heterogeneity (e.g.\, the presence of anoxic areas) leads to the appearance of different metabolic activities. \nPseudomonas aeruginosa has been used as a model bacterium for biofilm research; it causes biofilm-related chronic infections and presents high metabolic versatility\, together with an extreme antibiotic resistance. \nIn this work we have studied P. aeruginosa\, focusing in an essential enzyme for its growth\, Ribonucleotide Reductase (RNR). Ribonucleotide Reductases catalyse the reduction of ribonucleotides (NTPs) to deoxyribonucleotides (dNTPs)\, thereby providing the building blocks for DNA synthesis. There are three different RNR classes\, named class I\, class II and class III\, which are\, respectively\, oxygen-dependent\, oxygen-independent and oxygen-sensitive. The last two ones\, essential for anaerobic growth in Pseudomonas aeruginosa\, have been proved to be necessary for biofilm formation\, and therefore putative targets for new therapies against P. aeruginosa chronic infections. URL:https://ibecbarcelona.eu/event/phd-discussions-session-veronica-hortiguela-anna-crespo/ CATEGORIES:PhD Discussions Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150710T100000 DTEND;TZID=Europe/Madrid:20150710T110000 DTSTAMP:20260426T174500 CREATED:20150527T073448Z LAST-MODIFIED:20150527T073448Z UID:95855-1436522400-1436526000@ibecbarcelona.eu SUMMARY:PhD Discussions Session: Verónica Hortigüela & Anna Crespo DESCRIPTION:Developing a platform for receptor clustering studies\nVerónica Hortigüela\, Biomimetic systems for cell engineering group\nReceptors are signaling units that usually require interactions and associations with other molecules in complexes to trigger a signaling pathway. This process is known as receptor clustering and comes typically along with a simultaneous ligand clustering underneath the cell membrane. We have developed a strategy to precisely control the ligand distribution on a substrate at the nanoscale to study in detail receptor clustering processes. Herein we present a tunable platform based on self-assembled di-block copolymers that tend to segregate into nanostructures. Di-block copolymers are confined to a thin film providing a template for ligand patterning. \n  \nRibonucleotide Reductase anaerobic enzymes are essential for biofilm formation of Pseudomonas aeruginosa\nAnna Crespo\, Bacterial infections: antimicrobial therapies group\nMost chronic infections in humans are caused by communities of microorganisms living in organized structures\, known as biofilms. Biofilm-related infections\, such as pneumonia (in patients suffering for cystic fibrosis or chronic obstructive pulmonary disease –COPD-) and catheter-associated infections\, affect millions of people in the developed world. \nCell clusters in biofilms are characterized by presenting\, in its extracellular polymeric matrix\, gradients of oxygen\, nutrients and metabolic waste products. The so-formed chemical heterogeneity (e.g.\, the presence of anoxic areas) leads to the appearance of different metabolic activities. \nPseudomonas aeruginosa has been used as a model bacterium for biofilm research; it causes biofilm-related chronic infections and presents high metabolic versatility\, together with an extreme antibiotic resistance. \nIn this work we have studied P. aeruginosa\, focusing in an essential enzyme for its growth\, Ribonucleotide Reductase (RNR). Ribonucleotide Reductases catalyse the reduction of ribonucleotides (NTPs) to deoxyribonucleotides (dNTPs)\, thereby providing the building blocks for DNA synthesis. There are three different RNR classes\, named class I\, class II and class III\, which are\, respectively\, oxygen-dependent\, oxygen-independent and oxygen-sensitive. The last two ones\, essential for anaerobic growth in Pseudomonas aeruginosa\, have been proved to be necessary for biofilm formation\, and therefore putative targets for new therapies against P. aeruginosa chronic infections. URL:https://ibecbarcelona.eu/event/phd-discussions-session-veronica-hortiguela-anna-crespo-2/ CATEGORIES:PhD Discussions Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150706T150000 DTEND;TZID=Europe/Madrid:20150706T160000 DTSTAMP:20260426T174500 CREATED:20150701T122222Z LAST-MODIFIED:20150701T122253Z UID:17897-1436194800-1436198400@ibecbarcelona.eu SUMMARY:IBEC Seminar: Prof. Saman K. Halgamuge DESCRIPTION:Big Data Analytics in Metagenomics\nSaman K. Halgamuge\, Melbourne School of Engineering\, University of Melbourne\, Australia\nIn collaboration with researchers in Academia Sinica and Metabolomics Australia/Department of Botany at Melbourne\, we have been working in two areas of Bioinformatics: Metabolomics focusing on microbes and Metagenomics focusing on plants. Profiling large sets of data resulted from technological advances in whole genome sequencing and MALDI Imaging type technologies that can reveal vital information about the environment and plants\, which is our major or primary source of food on Earth. Recently we have demonstrated considerable success in using unsupervised clustering techniques to analyse genetic and metabolomic data. This includes analysis of viral quasi species\, metabolomics and microbial metagenomes. \nSome microbes in the environment appear to look very similar and found “living together” in communities in non-separable ways\, making them harder to culture in a lab. To make matters worst\, considering our belief\, if it is correct at all\, that we know only about up to 2% of the microbes around us. When we know only so little about the data labels\, in this case\, about the identity of the species. It is even more challenging to recognise patterns associated with the genomes of the quasispecies (a set of genetically related but non-identical viral mutant types\, which can also be referred to as strains\,) that are able to co-exist within the host. Uncovering information about quasi-species populations of microbes significantly benefits the study of disease progression\, antiviral drug design\, vaccine design and viral pathogenesis. We present a new analysis pipeline called ViQuaS for viral quasispecies spectrum reconstruction using short next-generation sequencing reads. ViQuaS is based on a novel reference-assisted de novo assembly algorithm for constructing local haplotypes. URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-saman-k-halgamuge/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150706T150000 DTEND;TZID=Europe/Madrid:20150706T160000 DTSTAMP:20260426T174500 CREATED:20150701T122222Z LAST-MODIFIED:20150701T122222Z UID:95860-1436194800-1436198400@ibecbarcelona.eu SUMMARY:IBEC Seminar: Prof. Saman K. Halgamuge DESCRIPTION:Big Data Analytics in Metagenomics\nSaman K. Halgamuge\, Melbourne School of Engineering\, University of Melbourne\, Australia\nIn collaboration with researchers in Academia Sinica and Metabolomics Australia/Department of Botany at Melbourne\, we have been working in two areas of Bioinformatics: Metabolomics focusing on microbes and Metagenomics focusing on plants. Profiling large sets of data resulted from technological advances in whole genome sequencing and MALDI Imaging type technologies that can reveal vital information about the environment and plants\, which is our major or primary source of food on Earth. Recently we have demonstrated considerable success in using unsupervised clustering techniques to analyse genetic and metabolomic data. This includes analysis of viral quasi species\, metabolomics and microbial metagenomes. \nSome microbes in the environment appear to look very similar and found “living together” in communities in non-separable ways\, making them harder to culture in a lab. To make matters worst\, considering our belief\, if it is correct at all\, that we know only about up to 2% of the microbes around us. When we know only so little about the data labels\, in this case\, about the identity of the species. It is even more challenging to recognise patterns associated with the genomes of the quasispecies (a set of genetically related but non-identical viral mutant types\, which can also be referred to as strains\,) that are able to co-exist within the host. Uncovering information about quasi-species populations of microbes significantly benefits the study of disease progression\, antiviral drug design\, vaccine design and viral pathogenesis. We present a new analysis pipeline called ViQuaS for viral quasispecies spectrum reconstruction using short next-generation sequencing reads. ViQuaS is based on a novel reference-assisted de novo assembly algorithm for constructing local haplotypes. URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-saman-k-halgamuge-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150626T100000 DTEND;TZID=Europe/Madrid:20150626T110000 DTSTAMP:20260426T174500 CREATED:20150527T073121Z LAST-MODIFIED:20150527T073212Z UID:16867-1435312800-1435316400@ibecbarcelona.eu SUMMARY:Phd Discussions Complementary Skills Session: Elisabeth Pain\, Science Careers DESCRIPTION:Planning for an Academic Career: A postdoc and beyond\n \nElisabeth Pain\, Contributing Editor for Science Careers\, Europe\nAcademic careers have become very competitive these days\, and the career decisions you make as a Ph.D. student or postdoc may greatly influence your chances of success later on. Choosing well your first postdoc is particularly important\, as you must ensure that you will be developing your skills while starting to make a name for yourself. When you should you start looking for a postdoc? What aspects should you consider? Where is the best place for you? In this session we will explore how to plan ahead and secure a successful postdoc\, and how to prepare for the next steps on the career ladder. \n  \nAfter obtaining an engineering diploma in biotechnology from her native France\, Elisabeth went to the United Kingdom to pursue her Ph.D. in immunology at the University of Bristol. Finding her calling in science journalism\, she went on to obtain a postgraduate diploma in journalism studies from Cardiff University\, with a bursary from the Association of British Science Writers. Since 2002\, Elisabeth has been working for Science Careers\, the online jobs and career guidance magazine of the journal Science – first in Cambridge as U.K. Editor and\, starting in 2004\, in Barcelona as Contributing Editor for Europe. Elisabeth has extensive experience covering a broad range of topics relevant to young scientists\, going from job and funding opportunities in academia to alternative careers and work-life balance. Elisabeth also regularly contributes Spanish and French news stories for Science and its policy blog Science Insider. URL:https://ibecbarcelona.eu/event/phd-discussions-complementary-skills-session-elisabeth-pain-science-careers/ CATEGORIES:PhD Discussions Complementary Skills Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150626T100000 DTEND;TZID=Europe/Madrid:20150626T110000 DTSTAMP:20260426T174500 CREATED:20150527T073121Z LAST-MODIFIED:20150527T073121Z UID:95854-1435312800-1435316400@ibecbarcelona.eu SUMMARY:Phd Discussions Complementary Skills Session: Elisabeth Pain\, Science Careers DESCRIPTION:Planning for an Academic Career: A postdoc and beyond\n \nElisabeth Pain\, Contributing Editor for Science Careers\, Europe\nAcademic careers have become very competitive these days\, and the career decisions you make as a Ph.D. student or postdoc may greatly influence your chances of success later on. Choosing well your first postdoc is particularly important\, as you must ensure that you will be developing your skills while starting to make a name for yourself. When you should you start looking for a postdoc? What aspects should you consider? Where is the best place for you? In this session we will explore how to plan ahead and secure a successful postdoc\, and how to prepare for the next steps on the career ladder. \n  \nAfter obtaining an engineering diploma in biotechnology from her native France\, Elisabeth went to the United Kingdom to pursue her Ph.D. in immunology at the University of Bristol. Finding her calling in science journalism\, she went on to obtain a postgraduate diploma in journalism studies from Cardiff University\, with a bursary from the Association of British Science Writers. Since 2002\, Elisabeth has been working for Science Careers\, the online jobs and career guidance magazine of the journal Science – first in Cambridge as U.K. Editor and\, starting in 2004\, in Barcelona as Contributing Editor for Europe. Elisabeth has extensive experience covering a broad range of topics relevant to young scientists\, going from job and funding opportunities in academia to alternative careers and work-life balance. Elisabeth also regularly contributes Spanish and French news stories for Science and its policy blog Science Insider. URL:https://ibecbarcelona.eu/event/phd-discussions-complementary-skills-session-elisabeth-pain-science-careers-2/ CATEGORIES:PhD Discussions Complementary Skills Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150626T090000 DTEND;TZID=Europe/Madrid:20150626T133000 DTSTAMP:20260426T174500 CREATED:20150608T064139Z LAST-MODIFIED:20150608T070433Z UID:16918-1435309200-1435325400@ibecbarcelona.eu SUMMARY:Kids' Day DESCRIPTION:  \nOn Friday\, 26th June IBEC\, in collaboration with IRB\, will celebrate its first edition of Kids’ Day\, when staff and researchers from the two institutes are invited to bring their children for a morning of science activities. \nKids’ Day is an opportunity for IBEC members to show their children their workplace\, and gives them the chance to be a ‘little scientist’ for a day. \nWho can participate?
\nTo make sure that we have a manageable and safe number of kids in the lab\, we have limited the number of participants to 60. Registration is on a first-come-first-served basis and priority will be given to the children of IBEC scientists and staff\, and then extended to nieces and nephews until all spaces are filled. \nThe activities will be targeted to children between 3 and 12 years old\, with the kids sorted into activity groups based on their ages. It’s recommended that kids be at least in P3 to assure that they will enjoy the whole event. \nAll 3-year-old kids need to be accompanied by a parent or a guardian. The other small children (4-5 years) can be accompanied by a parent only if they consider it necessary. Due to space restrictions\, parents of older children do not need to be present during the activities. Volunteers will look after the kids at all times. (If you are interested in volunteering for this\, please let us know at ibecevents@ibecbarcelona.eu) \nhttps://ibecbarcelona.eu/events/Kidsday \n  URL:https://ibecbarcelona.eu/event/16918/ LOCATION:IBEC\, Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain CATEGORIES:Social / Internal / PhD Committee END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150626T090000 DTEND;TZID=Europe/Madrid:20150626T133000 DTSTAMP:20260426T174500 CREATED:20150608T064139Z LAST-MODIFIED:20150608T064139Z UID:95857-1435309200-1435325400@ibecbarcelona.eu SUMMARY:Kids' Day DESCRIPTION:  \nOn Friday\, 26th June IBEC\, in collaboration with IRB\, will celebrate its first edition of Kids’ Day\, when staff and researchers from the two institutes are invited to bring their children for a morning of science activities. \nKids’ Day is an opportunity for IBEC members to show their children their workplace\, and gives them the chance to be a ‘little scientist’ for a day. \nWho can participate?
\nTo make sure that we have a manageable and safe number of kids in the lab\, we have limited the number of participants to 60. Registration is on a first-come-first-served basis and priority will be given to the children of IBEC scientists and staff\, and then extended to nieces and nephews until all spaces are filled. \nThe activities will be targeted to children between 3 and 12 years old\, with the kids sorted into activity groups based on their ages. It’s recommended that kids be at least in P3 to assure that they will enjoy the whole event. \nAll 3-year-old kids need to be accompanied by a parent or a guardian. The other small children (4-5 years) can be accompanied by a parent only if they consider it necessary. Due to space restrictions\, parents of older children do not need to be present during the activities. Volunteers will look after the kids at all times. (If you are interested in volunteering for this\, please let us know at ibecevents@ibecbarcelona.eu) \nhttp://ibecbarcelona.eu/events/Kidsday \n  URL:https://ibecbarcelona.eu/event/16918-2/ LOCATION:IBEC\, Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain CATEGORIES:Social / Internal / PhD Committee END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150619T100000 DTEND;TZID=Europe/Madrid:20150619T110000 DTSTAMP:20260426T174500 CREATED:20150410T120745Z LAST-MODIFIED:20150616T113709Z UID:15930-1434708000-1434711600@ibecbarcelona.eu SUMMARY:IBEC Seminar: Matteo Palma DESCRIPTION:Bio-inspired self-assembly for single-molecule investigations \n \nMatteo Palma\, Queen Mary University of London\nOne of the ultimate goals in nanotechnology is the ability to produce efficient devices based on individual molecules and nanostructures. Despite the many potential benefits envisioned for single-molecule technology (in electronics and biotechnology) the strategies employed to date suffer from various limitations. Principal among these limitations is the poor control over the molecular assembly of nanostructures and individual molecules with respect to one another\, as well as their position on devices with respect to other material components. \nI will first discuss techniques based on the combined use of lithographic nanopatterning and bio-molecular self-assembly to control the immobilization of biomolecules in arrayed nanodomains. I will show how this allows us to produce highly ordered\, self-assembled arrangements of nano-objects\, ranging from proteins to DNA nanostructures\, and bio-inorganic assemblies\, for a variety of (nanoscale) investigations. \nI will show how by specific design of the biomolecular nanoarrays\, it is possible to simultaneously monitor hundreds of protein/DNA binding events at the single-molecule level. Moreover I will discuss the use of our nanopatterned biomimetic surfaces to probe the importance of transmembrane proteins (integrins) clustering and geometric arrangement of binding sites\, in the formation of cell focal adhesions \nI will then highlight the broader utility of such nanopatterned surfaces for the self-organization (on surfaces) of bio-inorganic assemblies as well as DNA nanostructures and carbon nanotubes. In particular\, I will discuss how the combination of high resolution patterning with end-functional chemistry enables the assembly of 1D functional nanostructures in an orderly fashion. \nFinally\, building on our novel bottom-up assembly strategy for the formation of (chemically and geometrically) versatile carbon nanotube (CNTs) junctions\, I will present a universal approach for the generation of multifunctional nanomaterials that employ molecular building blocks assembled between DNA wrapped CNT electrodes. We will demonstrate single-molecule control in the formation of nanohybrids via the in-solution assembly of classes of molecular materials (organic\, and inorganic which display promising attributes) to DNA wrapped CNTs. We believe this may be a viable avenue towards the integration of these materials in complex and functional nano-architectures. \nOur findings are of general interest for the controlled assembly of a broad range of functional molecules and nanostructures\, towards the fabrication of solution-processable nanoscale devices. Moreover\, we believe that the knowledge developed makes a significant contribution towards the facile fabrication of nanohybrid materials for single-molecule investigations. Future technologies will require devices of this type in a variety of key areas\, including biodiagnostics\, ultra-high speed computation\, bioelectronics\, and for renewable energy applications. URL:https://ibecbarcelona.eu/event/ibec-seminar-matteo-palma/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150619T100000 DTEND;TZID=Europe/Madrid:20150619T110000 DTSTAMP:20260426T174500 CREATED:20150410T120745Z LAST-MODIFIED:20150410T120745Z UID:95844-1434708000-1434711600@ibecbarcelona.eu SUMMARY:IBEC Seminar: Matteo Palma DESCRIPTION:Bio-inspired self-assembly for single-molecule investigations \n \nMatteo Palma\, Queen Mary University of London\nOne of the ultimate goals in nanotechnology is the ability to produce efficient devices based on individual molecules and nanostructures. Despite the many potential benefits envisioned for single-molecule technology (in electronics and biotechnology) the strategies employed to date suffer from various limitations. Principal among these limitations is the poor control over the molecular assembly of nanostructures and individual molecules with respect to one another\, as well as their position on devices with respect to other material components. \nI will first discuss techniques based on the combined use of lithographic nanopatterning and bio-molecular self-assembly to control the immobilization of biomolecules in arrayed nanodomains. I will show how this allows us to produce highly ordered\, self-assembled arrangements of nano-objects\, ranging from proteins to DNA nanostructures\, and bio-inorganic assemblies\, for a variety of (nanoscale) investigations. \nI will show how by specific design of the biomolecular nanoarrays\, it is possible to simultaneously monitor hundreds of protein/DNA binding events at the single-molecule level. Moreover I will discuss the use of our nanopatterned biomimetic surfaces to probe the importance of transmembrane proteins (integrins) clustering and geometric arrangement of binding sites\, in the formation of cell focal adhesions \nI will then highlight the broader utility of such nanopatterned surfaces for the self-organization (on surfaces) of bio-inorganic assemblies as well as DNA nanostructures and carbon nanotubes. In particular\, I will discuss how the combination of high resolution patterning with end-functional chemistry enables the assembly of 1D functional nanostructures in an orderly fashion. \nFinally\, building on our novel bottom-up assembly strategy for the formation of (chemically and geometrically) versatile carbon nanotube (CNTs) junctions\, I will present a universal approach for the generation of multifunctional nanomaterials that employ molecular building blocks assembled between DNA wrapped CNT electrodes. We will demonstrate single-molecule control in the formation of nanohybrids via the in-solution assembly of classes of molecular materials (organic\, and inorganic which display promising attributes) to DNA wrapped CNTs. We believe this may be a viable avenue towards the integration of these materials in complex and functional nano-architectures. \nOur findings are of general interest for the controlled assembly of a broad range of functional molecules and nanostructures\, towards the fabrication of solution-processable nanoscale devices. Moreover\, we believe that the knowledge developed makes a significant contribution towards the facile fabrication of nanohybrid materials for single-molecule investigations. Future technologies will require devices of this type in a variety of key areas\, including biodiagnostics\, ultra-high speed computation\, bioelectronics\, and for renewable energy applications. URL:https://ibecbarcelona.eu/event/ibec-seminar-matteo-palma-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150616T160000 DTEND;TZID=Europe/Madrid:20150616T170000 DTSTAMP:20260426T174500 CREATED:20150604T150254Z LAST-MODIFIED:20150604T150254Z UID:95856-1434470400-1434474000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Javier G. Fernández DESCRIPTION:Bioinspired materials\n \nJavier G. Fernández\, Assistant Professor and Founder Academic Member · Singapore University of Technology and Design\nNature is abundant with materials that possess extraordinary mechanical characteristics. New techniques in biochemistry and advances in microelectronic engineering are boosting our knowledge of biological materials\, and providing tools to fabricate at the scale at which these materials are made in nature. This investigation of the structural organization of these materials leads to understanding of the principles of natural materials design that are beginning to be harnessed to fabricate biologically-inspired composites for materials engineering with tunable properties that mimic living materials\, which might provide useful for environmental challenges\, as well as medical applications. URL:https://ibecbarcelona.eu/event/ibec-seminar-javier-g-fernandez-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150616T160000 DTEND;TZID=Europe/Madrid:20150616T170000 DTSTAMP:20260426T174500 CREATED:20150604T150254Z LAST-MODIFIED:20150604T150254Z UID:16893-1434470400-1434474000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Javier G. Fernández DESCRIPTION:Bioinspired materials\n \nJavier G. Fernández\, Assistant Professor and Founder Academic Member · Singapore University of Technology and Design\nNature is abundant with materials that possess extraordinary mechanical characteristics. New techniques in biochemistry and advances in microelectronic engineering are boosting our knowledge of biological materials\, and providing tools to fabricate at the scale at which these materials are made in nature. This investigation of the structural organization of these materials leads to understanding of the principles of natural materials design that are beginning to be harnessed to fabricate biologically-inspired composites for materials engineering with tunable properties that mimic living materials\, which might provide useful for environmental challenges\, as well as medical applications. URL:https://ibecbarcelona.eu/event/ibec-seminar-javier-g-fernandez/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150612T100000 DTEND;TZID=Europe/Madrid:20150612T110000 DTSTAMP:20260426T174500 CREATED:20150311T075156Z LAST-MODIFIED:20150608T143446Z UID:15401-1434103200-1434106800@ibecbarcelona.eu SUMMARY:IBEC Seminar: Alexandra P. Marques DESCRIPTION:Driving skin wound healing: stem cells and extracellular matrix role\n \nAlexandra P. Marques\, 3B’s Research Group\, University of Minho\, Portugal\nWound care products have evolved into skin tissue engineered substitutes\, which despite the longest history of application and the highest record of marketing\, proved to represent replacement strategies instead of promoting tissue regeneration. \nCurrent research indicates that the interactions between resident progenitor cells and their niche dictate the triggering of skin regeneration pathway. In alignment\, mesenchymal stem cells (MSCs)-based therapies\, have been proposed to enhance cutaneous wound healing.  The rationale lies on transplanted cells ability to interact/respond to the wound microenvironment\, which is advantageous when compared to the exogenous administration of healing factors. However\, the involved mechanisms are still elusive and poor outcomes were achieved in terms of attainment of functional skin tissue due to low cell survival rates\, and poor engraftment or cell fusion upon transplantation.  Extracellular matrix (ECM)-mimicking is currently seen as the “Holy Grail” of Tissue Engineering in the sense that by recreating natural tissues microenvironments researchers will be able to increase the residence time and consequently the action of the transplanted cells and thus uncover “therapeutic niches”. \nUnder this context we have been exploring two perspectives; one takes advantage of the tunable ECM-like properties along with the 3D support that hydrogels can provide\, and the second benefits from an intact native ECM offered by cell sheet engineering technology. Hydrogels features such as high hygroscopic nature\, tunable elasticity and facilitated mass transportation\, render such materials attractive for the development of skin ECM-analogues. Although succeeding in improved cell engraftment\, hydrogels fail to provide biological instructive cues as well as cell adhesion sites\, only overcome by cell adhesive peptides bonding to polymers backbone. We developed a new method of processing gellan gum-based materials\, having as start material gellan gum-based hydrogels\, to obtain structures that exhibit features of both sponges and hydrogels depicting intrinsic cell-adhesive properties. By creating constructs comprising adipose tissue cells and artificial and natural ECM we were able to demonstrated that skin healing is dependent on tissue engineered constructs self cell-cell and cell-ECM interactions\, as well as on constructs cell-cell interactions and paracrine signaling with resident cells. In particular\, our results suggest that cell-ECM and cell-cell interactions have a dramatic effect over re-epithelialisation. In opposition\, neo-vascularisation did not seem to be dependent on the nature of the cell-ECM interactions\, but was significantly improved with the incorporation of microvascular endothelial cells. \nUltimately the generation of knowledge on how to direct skin regeneration lead the creation of “off-the-shelf” 3D stem cell-based engineered products inspired by the role of wound healing microenvironments. URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandra-p-marques/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150612T100000 DTEND;TZID=Europe/Madrid:20150612T110000 DTSTAMP:20260426T174500 CREATED:20150311T075156Z LAST-MODIFIED:20150311T075156Z UID:95840-1434103200-1434106800@ibecbarcelona.eu SUMMARY:IBEC Seminar: Alexandra P. Marques DESCRIPTION:Driving skin wound healing: stem cells and extracellular matrix role\n \nAlexandra P. Marques\, 3B’s Research Group\, University of Minho\, Portugal\nWound care products have evolved into skin tissue engineered substitutes\, which despite the longest history of application and the highest record of marketing\, proved to represent replacement strategies instead of promoting tissue regeneration. \nCurrent research indicates that the interactions between resident progenitor cells and their niche dictate the triggering of skin regeneration pathway. In alignment\, mesenchymal stem cells (MSCs)-based therapies\, have been proposed to enhance cutaneous wound healing.  The rationale lies on transplanted cells ability to interact/respond to the wound microenvironment\, which is advantageous when compared to the exogenous administration of healing factors. However\, the involved mechanisms are still elusive and poor outcomes were achieved in terms of attainment of functional skin tissue due to low cell survival rates\, and poor engraftment or cell fusion upon transplantation.  Extracellular matrix (ECM)-mimicking is currently seen as the “Holy Grail” of Tissue Engineering in the sense that by recreating natural tissues microenvironments researchers will be able to increase the residence time and consequently the action of the transplanted cells and thus uncover “therapeutic niches”. \nUnder this context we have been exploring two perspectives; one takes advantage of the tunable ECM-like properties along with the 3D support that hydrogels can provide\, and the second benefits from an intact native ECM offered by cell sheet engineering technology. Hydrogels features such as high hygroscopic nature\, tunable elasticity and facilitated mass transportation\, render such materials attractive for the development of skin ECM-analogues. Although succeeding in improved cell engraftment\, hydrogels fail to provide biological instructive cues as well as cell adhesion sites\, only overcome by cell adhesive peptides bonding to polymers backbone. We developed a new method of processing gellan gum-based materials\, having as start material gellan gum-based hydrogels\, to obtain structures that exhibit features of both sponges and hydrogels depicting intrinsic cell-adhesive properties. By creating constructs comprising adipose tissue cells and artificial and natural ECM we were able to demonstrated that skin healing is dependent on tissue engineered constructs self cell-cell and cell-ECM interactions\, as well as on constructs cell-cell interactions and paracrine signaling with resident cells. In particular\, our results suggest that cell-ECM and cell-cell interactions have a dramatic effect over re-epithelialisation. In opposition\, neo-vascularisation did not seem to be dependent on the nature of the cell-ECM interactions\, but was significantly improved with the incorporation of microvascular endothelial cells. \nUltimately the generation of knowledge on how to direct skin regeneration lead the creation of “off-the-shelf” 3D stem cell-based engineered products inspired by the role of wound healing microenvironments. URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandra-p-marques-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150529T100000 DTEND;TZID=Europe/Madrid:20150529T110000 DTSTAMP:20260426T174500 CREATED:20150527T072015Z LAST-MODIFIED:20150527T072015Z UID:16865-1432893600-1432897200@ibecbarcelona.eu SUMMARY:PhD Discussions Sessions: Lorena de Oñate & Anita Kosmalska DESCRIPTION:Research on cardiac differentiation from pluripotent stem cells: how to get beating cells in a dish\nLorena de Oñate\, Pluripotent stem cells and activation of endogenous tissue programs for organ regeneration group\nProbably\, the gain in organ complexity and cell function has led to a decrease in healing capacities in the adult mammalian heart. In an effort to generate new venues for the generation of functional cardiac cells we have explored the possibility to manipulate cell fate and plasticity making use of different cellular systems. First\, taking advantage of pluripotent stem cells we have defined chemically based protocols in order to generate cardiac cells from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSC). Second\, by a cell conversion approach\, we have been able to produce cardiomyocyte-like cells from human fibroblasts by overexpression of specific lineage transcription factors. In parallel\, to overcome several drawbacks related to both processes (i.e: purity of final cell populations)\, we have efficiently developed a reporter cell line for the cardiac gene alpha Myosin Heavy Chain (MYH6) by both TALEN and CRISPR/CAS9 genome editing approaches that will help us to define accurate protocols for cardiac differentiation\, and more importantly\, to underscore the molecular and cellular events driving human cardiomyocyte differentiation. \n  \nPhysical principles of membrane remodelling during cell mechanoadaptation\nAnita Kosmalska\, Cellular and respiratory biomechanic group\nBiological processes in any physiological environment involve changes in cell shape\, which must be accommodated by their physical envelope – the bilayer membrane. However\, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive\, local\, almost instantaneous\, prior to any active remodelling\, and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed\, cells reabsorb the invaginations through an active process with duration of the order of minutes. URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-lorena-de-onate-anita-kosmalska/ CATEGORIES:PhD Discussions Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150529T100000 DTEND;TZID=Europe/Madrid:20150529T110000 DTSTAMP:20260426T174500 CREATED:20150527T072015Z LAST-MODIFIED:20150527T072015Z UID:95853-1432893600-1432897200@ibecbarcelona.eu SUMMARY:PhD Discussions Sessions: Lorena de Oñate & Anita Kosmalska DESCRIPTION:Research on cardiac differentiation from pluripotent stem cells: how to get beating cells in a dish\nLorena de Oñate\, Pluripotent stem cells and activation of endogenous tissue programs for organ regeneration group\nProbably\, the gain in organ complexity and cell function has led to a decrease in healing capacities in the adult mammalian heart. In an effort to generate new venues for the generation of functional cardiac cells we have explored the possibility to manipulate cell fate and plasticity making use of different cellular systems. First\, taking advantage of pluripotent stem cells we have defined chemically based protocols in order to generate cardiac cells from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSC). Second\, by a cell conversion approach\, we have been able to produce cardiomyocyte-like cells from human fibroblasts by overexpression of specific lineage transcription factors. In parallel\, to overcome several drawbacks related to both processes (i.e: purity of final cell populations)\, we have efficiently developed a reporter cell line for the cardiac gene alpha Myosin Heavy Chain (MYH6) by both TALEN and CRISPR/CAS9 genome editing approaches that will help us to define accurate protocols for cardiac differentiation\, and more importantly\, to underscore the molecular and cellular events driving human cardiomyocyte differentiation. \n  \nPhysical principles of membrane remodelling during cell mechanoadaptation\nAnita Kosmalska\, Cellular and respiratory biomechanic group\nBiological processes in any physiological environment involve changes in cell shape\, which must be accommodated by their physical envelope – the bilayer membrane. However\, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive\, local\, almost instantaneous\, prior to any active remodelling\, and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed\, cells reabsorb the invaginations through an active process with duration of the order of minutes. URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-lorena-de-onate-anita-kosmalska-2/ CATEGORIES:PhD Discussions Session END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150526T100000 DTEND;TZID=Europe/Madrid:20150526T160000 DTSTAMP:20260426T174500 CREATED:20150511T135716Z LAST-MODIFIED:20170801T130953Z UID:16484-1432634400-1432656000@ibecbarcelona.eu SUMMARY:Workshop: Financiación de KETs en Salud DESCRIPTION:  \n10:00h-10:30h Bienvenida\nJosep Samitier\, Coordinador científico de la Plataforma Española de Nanomedicina\nJosé Luis Fernández\, Presidente de Fenin Catalunya\nCarles Pizarro\, Vice-Presidente de la Plataforma Tecnológica Española de Fotónica \n10:30h-10:55h Estrategia industrial de Cataluña: programa de impulso del ámbito de las industrias de la salud y ciencias de la vida. (Montserrat Alavedra\, ACC1O) \n10:55h-11:20h Visión general de los instrumentos de CDTI (Cecilia Hernández\, CDTI) \n11:20h -11:35h Pausa Café \n11:35h-12:00h Recomendaciones útiles para el sector de salud y tecnologías sanitarias (Juan Luis Romera\, CDTI) \n12:00h-13:30h Mesa redonda- Instrumentos de financiación para empresas\nSME instrument (Miguel Roncales\, ALPHASIP; Javier Bezares\, BCB*)\n Financiación CDTI (Eduard Diviu\, Sagetis Biotech; Eli Diez\, Progenika)\n Compra Publica Innovadora (Gloria Palomar\, Directora de Gestió de la Fundació Parc Taulí)\n Financiación de Spin-offs y Start-ups (*) \n13:30h-14:00h Debate y clausura de la sesión \n14:00h-15:00h Almuerzo y Networking \n15:00h-16:00h Encuentros bilaterales con técnicos de CDTI y ACC1O (necesaria solicitud previa por email a mprades@ibecbarcelona.eu) \n  \nAsistencia gratuita. Enlace para registrarse:\nhttp://www.plataformatecnologiasanitaria.es/forosempresariales/ver/evento/216 \n  URL:https://ibecbarcelona.eu/event/workshop-financiacion-de-kets-en-salud/ LOCATION:Sala Polivalente\, PCB\, Baldiri Reixac 4-8\, 08028 Barcelona CATEGORIES:Other END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150526T100000 DTEND;TZID=Europe/Madrid:20150526T160000 DTSTAMP:20260426T174500 CREATED:20150511T135716Z LAST-MODIFIED:20150511T135716Z UID:95851-1432634400-1432656000@ibecbarcelona.eu SUMMARY:Workshop: Financiación de KETs en Salud DESCRIPTION:  \n10:00h-10:30h Bienvenida\nJosep Samitier\, Coordinador científico de la Plataforma Española de Nanomedicina\nJosé Luis Fernández\, Presidente de Fenin Catalunya\nCarles Pizarro\, Vice-Presidente de la Plataforma Tecnológica Española de Fotónica \n10:30h-10:55h Estrategia industrial de Cataluña: programa de impulso del ámbito de las industrias de la salud y ciencias de la vida. (Montserrat Alavedra\, ACC1O) \n10:55h-11:20h Visión general de los instrumentos de CDTI (Cecilia Hernández\, CDTI) \n11:20h -11:35h Pausa Café \n11:35h-12:00h Recomendaciones útiles para el sector de salud y tecnologías sanitarias (Juan Luis Romera\, CDTI) \n12:00h-13:30h Mesa redonda- Instrumentos de financiación para empresas\nSME instrument (Miguel Roncales\, ALPHASIP; Javier Bezares\, BCB*)\n Financiación CDTI (Eduard Diviu\, Sagetis Biotech; Eli Diez\, Progenika)\n Compra Publica Innovadora (Gloria Palomar\, Directora de Gestió de la Fundació Parc Taulí)\n Financiación de Spin-offs y Start-ups (*) \n13:30h-14:00h Debate y clausura de la sesión \n14:00h-15:00h Almuerzo y Networking \n15:00h-16:00h Encuentros bilaterales con técnicos de CDTI y ACC1O (necesaria solicitud previa por email a mprades@ibecbarcelona.eu) \n  \nAsistencia gratuita. Enlace para registrarse:\nhttp://www.plataformatecnologiasanitaria.es/forosempresariales/ver/evento/216 \n  URL:https://ibecbarcelona.eu/event/workshop-financiacion-de-kets-en-salud-2/ LOCATION:Sala Polivalente\, PCB\, Baldiri Reixac 4-8\, 08028 Barcelona CATEGORIES:Other END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150522T100000 DTEND;TZID=Europe/Madrid:20150522T110000 DTSTAMP:20260426T174500 CREATED:20150408T132341Z LAST-MODIFIED:20150408T132405Z UID:15816-1432288800-1432292400@ibecbarcelona.eu SUMMARY:IBEC Seminar: Thomas Graf DESCRIPTION:Mechanisms of transcription factor induced transdifferentiation and reprogramming to pluripotency\n \nThomas Graf\, Gene Regulation\, Stem Cells and Differentiation Programme\, CRG / Pompeu Fabra University\nWork by many laboratories has shown that even fully differentiated cells are remarkably plastic and can be reprogrammed into alternative fates. This discovery has revolutionized our understanding of how cell decide what to become and has major implications for the modeling and therapy of diseases that affect the production of differentiated cells. \nOur earlier work has shown that the myeloid transcription factor C/EBPa induces B cells to transdifferentiate into macrophages at high efficiencies. We have now found that the process forces the intersection of two enhancer pathways that become activated during normal hematopoietic differentiation. \nRecently we reported that the transient expression of C/EBPa in B cells\, followed by expression of the pluripotency factors Oct4\, Sox2\, Klf4 and c-Myc (OSKM)\, poises the cells for very rapid and highly efficient reprogramming into induced pluripotent stem cells. Our findings have removed a major obstacle in studying cell reprogramming and permitted us to investigate how C/EBPa leads to the almost immediate accessibility of pluripotency genes to binding by Oct4. Our new data provide unprecedented insights into the earliest events leading to activation of the pluripotency gene regulatory network\, resulting in somatic cell reprogramming. URL:https://ibecbarcelona.eu/event/ibec-seminar-thomas-graf/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150522T100000 DTEND;TZID=Europe/Madrid:20150522T110000 DTSTAMP:20260426T174500 CREATED:20150408T132341Z LAST-MODIFIED:20150408T132341Z UID:95842-1432288800-1432292400@ibecbarcelona.eu SUMMARY:IBEC Seminar: Thomas Graf DESCRIPTION:Mechanisms of transcription factor induced transdifferentiation and reprogramming to pluripotency\n \nThomas Graf\, Gene Regulation\, Stem Cells and Differentiation Programme\, CRG / Pompeu Fabra University\nWork by many laboratories has shown that even fully differentiated cells are remarkably plastic and can be reprogrammed into alternative fates. This discovery has revolutionized our understanding of how cell decide what to become and has major implications for the modeling and therapy of diseases that affect the production of differentiated cells. \nOur earlier work has shown that the myeloid transcription factor C/EBPa induces B cells to transdifferentiate into macrophages at high efficiencies. We have now found that the process forces the intersection of two enhancer pathways that become activated during normal hematopoietic differentiation. \nRecently we reported that the transient expression of C/EBPa in B cells\, followed by expression of the pluripotency factors Oct4\, Sox2\, Klf4 and c-Myc (OSKM)\, poises the cells for very rapid and highly efficient reprogramming into induced pluripotent stem cells. Our findings have removed a major obstacle in studying cell reprogramming and permitted us to investigate how C/EBPa leads to the almost immediate accessibility of pluripotency genes to binding by Oct4. Our new data provide unprecedented insights into the earliest events leading to activation of the pluripotency gene regulatory network\, resulting in somatic cell reprogramming. URL:https://ibecbarcelona.eu/event/ibec-seminar-thomas-graf-2/ CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150520T200000 DTEND;TZID=Europe/Madrid:20150520T220000 DTSTAMP:20260426T174500 CREATED:20150519T130950Z LAST-MODIFIED:20170801T130730Z UID:16645-1432152000-1432159200@ibecbarcelona.eu SUMMARY:Pint of Science: "The forces that drive cancer cells” and “Cell\, the force be with you” DESCRIPTION:Pint of Science\n \nCafé de les Delícies\, Rambla del Raval\n \n  \nGroup leader Xavier Trepat and postdoc Laura Casares are set to take part in a global science outreach event taking place simultaneously in 9 countries and 50 cities all over the world. \nThe Pint of Science festival on 18th-20th May aims to deliver interesting\, fun and relevant talks on the latest scientific research by the people who carry it out – in the pub! \nXavi and Laura will giving talks on “The forces that drive cancer cells” and “Cell\, the force be with you” on Wednesday 20th May from 20:00 at the Café de les Delícies on Rambla del Raval. Other scientists taking part in Barcelona pubs include researchers from the UB\, ICFO\, CRG and several other centres\, covering topics from “El nanomundo perdido” and “El aire de Barcelona” to “Is God playing dice?” at venues including the Michael Collins\, Garage Beer and the Black Lab. \nPint of Science\, which was established by a community of postgraduate and postdoctoral researchers at Imperial College in 2012\, takes place annually over three days simultaneously in pubs in the UK\, Ireland\, France\, Italy\, the US\, Australia\, Germany and Spain. \nIf you’d like more information\, visit http://pintofscience.es/eventos/barcelona/\, or please come along to support Xavi and Laura on the night! URL:https://ibecbarcelona.eu/event/pint-of-science-the-forces-that-drive-cancer-cells-and-cell-the-force-be-with-you/ LOCATION:Café de les Delícies\, Rambla del Raval 47\, Barcelona\, Spain CATEGORIES:Outreach / Fair / Festival END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150520T200000 DTEND;TZID=Europe/Madrid:20150520T220000 DTSTAMP:20260426T174500 CREATED:20150519T130950Z LAST-MODIFIED:20150519T130950Z UID:95852-1432152000-1432159200@ibecbarcelona.eu SUMMARY:Pint of Science: "The forces that drive cancer cells” and “Cell\, the force be with you” DESCRIPTION:Pint of Science\n \nCafé de les Delícies\, Rambla del Raval\n \n  \nGroup leader Xavier Trepat and postdoc Laura Casares are set to take part in a global science outreach event taking place simultaneously in 9 countries and 50 cities all over the world. \nThe Pint of Science festival on 18th-20th May aims to deliver interesting\, fun and relevant talks on the latest scientific research by the people who carry it out – in the pub! \nXavi and Laura will giving talks on “The forces that drive cancer cells” and “Cell\, the force be with you” on Wednesday 20th May from 20:00 at the Café de les Delícies on Rambla del Raval. Other scientists taking part in Barcelona pubs include researchers from the UB\, ICFO\, CRG and several other centres\, covering topics from “El nanomundo perdido” and “El aire de Barcelona” to “Is God playing dice?” at venues including the Michael Collins\, Garage Beer and the Black Lab. \nPint of Science\, which was established by a community of postgraduate and postdoctoral researchers at Imperial College in 2012\, takes place annually over three days simultaneously in pubs in the UK\, Ireland\, France\, Italy\, the US\, Australia\, Germany and Spain. \nIf you’d like more information\, visit http://pintofscience.es/eventos/barcelona/\, or please come along to support Xavi and Laura on the night! URL:https://ibecbarcelona.eu/event/pint-of-science-the-forces-that-drive-cancer-cells-and-cell-the-force-be-with-you-2/ LOCATION:Café de les Delícies\, Rambla del Raval 47\, Barcelona\, Spain CATEGORIES:Outreach / Fair / Festival END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20150518T090000 DTEND;TZID=Europe/Madrid:20150519T170000 DTSTAMP:20260426T174500 CREATED:20150428T065309Z LAST-MODIFIED:20150507T062030Z UID:16399-1431939600-1432054800@ibecbarcelona.eu SUMMARY:Symposium TAU-IBEC DESCRIPTION:Symposium TAU-IBEC: Nanobiotechnology and Nanomedicine: Moving forward the convergence between life sciences\, medicine and engineering at the nanoscale \n \nResearchers from IBEC and Tel Aviv University (TAU) will come together for a joint symposium supported by AGAUR. Group leaders from both sides will present their work\, and try to identify synergies and opportunities for collaboration. \nProgramme: \nMonday\, 18th May\n09:00 – 09:30 Registration\n09:30 – 09:40 Opening Ceremony – with Dr. Lluís Rovira (Director of CERCA Institution)\n09:40 – 10:10 Presentation of IBEC. Prof. Josep Samitier\n10:10 – 10:40 Presentation of TAU. Prof. Ehud Gazit\n10:40 – 11:00 Coffee break\n11:00 – 11:30 FTA & Harnessing nanomedicine for precision therapy. Prof. Dan Peer\n11:30 – 11:55 Nanomedicines for malaria. Dr. Xavier Fernández-Busquets\n11:55 – 12:20 Polymer therapeutics. Prof. Ronit Sachi-Fainaro\n12:20 – 12:45 Smart nano-bio-devices. Dr. Samuel Sánchez\n12:45 – 13:10 Panel discussion – synergies and possible collaboration\n13:10 – 14:30 Lunch and networking\n14:30 – 14:55 Optopharmacology. Prof. Pau Gorostiza\n14:55 – 15:20 Controlled drug delivery. Prof. Ehud Gazit\n15:20 – 15:45 NanoBiophysics. Dr. Lorenzo Albertazzi\n15:45 – 16:10 Nanoscale bioelectrical characterization. Dr. Gabriel Gomila\n16:10 – 17:00 Panel discussion – synergies and possible collaboration \nTuesday\, 19th May\n09:30 – 09:55 Drug-carrying phage nano medicines. Prof. Itai Benhar\n09:55 – 10:20 Nanobioengineering for advanced in vitro diagnostics Organ on a chip. Prof. Josep Samitier\n10:20 – 10:45 Biomimetic systems. Dr. Elena Martinez\n10:45 – 11:05 Panel discussion – synergies and possible collaboration\n11:15 – 11:35 Coffee Break \n11:35 – 12:00 Biomaterials for regenerative therapies. Dr. Elisabeth Engel\n12:00 – 12:25 Tissue engineering and regenerative medicine. Prof. Tal Dvir\n12:25 – 12:50 Pluripotent stem cells and activation of endogenous tissue programs for organ regeneration. Dr. Núria Montserrat\n12:50 – 13:10 Panel discussion – synergies and possible collaboration\n13:10 – 13:30 Closing ceremony and working plan\n13:30 Lunch (just for speakers) \nAll IBEC researchers are warmly invited to intend. Registrations must be received by 30th April at the following link. https://ibecbarcelona.eu/events/IBEC-TAU-Joint-Symposia \nWe look forward to seeing you there. URL:https://ibecbarcelona.eu/event/symposium-tau-ibec/ LOCATION:Sala Polivalente\, PCB\, Baldiri Reixac 4-8\, 08028 Barcelona CATEGORIES:IBEC Symposium / Conference / Congress / Workshop END:VEVENT END:VCALENDAR