BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute for Bioengineering of Catalonia
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20140101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20140330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20141026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20150329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20151025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20160327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20161030T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T150000
DTEND;TZID=UTC:20160122T160000
DTSTAMP:20260426T114000
CREATED:20160114T100133Z
LAST-MODIFIED:20160114T100133Z
UID:95887-1453474800-1453478400@ibecbarcelona.eu
SUMMARY:IBEC Seminar (Bellvitge): Martin Lohse\, University of Würzburg
DESCRIPTION:Optical studies of receptor activation and signaling\nProf. Dr. Martin Lohse\, Chairman of the Rudolf Virchow Center for Experimental Biomedicine\, University of Würzburg\, Germany\nCyclic nucleotides (cAMP and cGMP) belong to the most ubiquitous intracellular messengers\, are produced in response to multiple stimuli\, act on several intracellular targets\, and regulate a vast array of biological functions. \nHowever\, in spite of the fundamental importance of these signaling systems\, very little is known about the temporal and spatial patterns of their production and action. In fact\, space and time seem to play almost no role in current concepts of intracellular signaling. To gain an insight into these dimensions\, we develop methods to create images of these second messengers in intact cells\, and to resolve these intracellular signals in space and in time.
URL:https://ibecbarcelona.eu/event/ibec-seminar-bellvitge-martin-lohse-university-of-wurzburg-2/
LOCATION:Aulari Nou de Bellvitge\, Sala de Graus (room 001\, ground floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T120000
DTSTAMP:20260426T114000
CREATED:20160114T095549Z
LAST-MODIFIED:20160118T081141Z
UID:20901-1453456800-1453464000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Silvia Pittolo
DESCRIPTION:“Development of light-modulated allosteric ligands for remote\, non-invasive control of neuronal receptors”\nSilvia Pittolo\, Nanoprobes and Nanoswitches group\nSilvia will be defending her PhD thesis on Friday 22nd January at 10:00 in the Aulari Nou de Bellvitge\, room 402 (4th floor) at the Bellvitge Campus. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-silvia-pittolo/
LOCATION:Aulari Nou de Bellvitge\, room 402 (4th floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T120000
DTSTAMP:20260426T114000
CREATED:20160114T095549Z
LAST-MODIFIED:20160114T095549Z
UID:95886-1453456800-1453464000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Silvia Pittolo
DESCRIPTION:“Development of light-modulated allosteric ligands for remote\, non-invasive control of neuronal receptors”\nSilvia Pittolo\, Nanoprobes and Nanoswitches group\nSilvia will be defending her PhD thesis on Friday 22nd January at 10:00 in the Aulari Nou de Bellvitge\, room 402 (4th floor) at the Bellvitge Campus. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-silvia-pittolo-2/
LOCATION:Aulari Nou de Bellvitge\, room 402 (4th floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T110000
DTSTAMP:20260426T114000
CREATED:20151027T094305Z
LAST-MODIFIED:20151027T094305Z
UID:95875-1453456800-1453460400@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Ana María Solórzano and Joan Martí Muñoz
DESCRIPTION:Carbon Monoxide Poisoning: Societal Impact\, Physiological Mechanism and Associated Chemical Instrumentation\nAna María Solórzano\, Signal and information processing for sensing systems group\nThe hazardousness of carbon monoxide is based on the inability of humans to detect it. Carbon monoxide is not irritating and has no color\, odor or either taste. The exposure to this gas can starve critical body organs specially vital organs like brain and heart. \nThe study and analysis of CO poisoning is not new. Even though in the last decades the society has been raised awareness on CO hazard\, accidental deaths are still produced by exposure to this gas. \nThe health effects of the CO poisoning depend on its concentration and time exposure. Health problems are noticeable with concentrations since 0.01% (100ppm).; this is the reason that the medical Instrumentation is an essential tool for the detection of CO. There is a kind of instrumentation\, which detects CO in the bloodstream\, and in the atmosphere but the early detection of this compound still is a challenge. \nWe are exploring how multi gas sensor arrays can be an effective solution to detect CO faster than typical alarms. \n  \nCalcium releasing ormoglass coated PLA nanofibers: A new approach for bone regeneration\nJoan Martí Muñoz\, Biomaterials for regenerative therapies group\nBone fracture healing has become a serious problem in the last decades in part due to the increase in life expectancy (1). The use of strategies that help body to restore bone are needed to increase the quality life of people suffering this problem. Among this strategies\, the use of natural sources such as; bone\, growth factors and other biomolecules has become an efficient option\, but present some limitations like money cost\, amount limitation and storage\, extra surgeries\, rejection and possible disease transmission (1). \nThe use of synthetic materials can be an effective option. However they need to be tuned to include the proper bioactive signals. Hybrid materials are and interesting alternative. Their organic phase\, normally a biodegradable biopolymer\, holds the mechanical stress while their inorganic phase\, a glass or ceramic\, provides the needed bioactivity to recruit cells and produce bone. In many cases\, the masking of the bioactive inorganic phase embedded in the organic matrix and undesired phase-detachments must be solved to increase efectiveness (2). Another limitation is the poor vascularization that synthetic materials induce. \nPrevious studies in our group demonstrated that extracellular Ca2+ release can promote angiogenesis (3). Here we present two different strategies: the first one consisting in CaP Ti-doped degradable ormoglass nanoparticles embedded inside polylactic acid (PLA) electrospun bioresorbable nanofibers; the second one consisting in CaP Si-doped degradable ormoglass nanoparticles (2) covalently attached on the surface of PLA electrospun nanofibers. In both cases the Ca2+ release by the ormoglass nanoparticles may activate the proper cell responses while the polymer provides the needed support to hold the particles and allow tissue growth. In the second case the attempt is to solve nanoparticle masking and detachment. \n1 M. Navarro et al. J. R. Soc. Interface (2008) 5\, 1137-1158.\n2 N. Sachot et al. J. R. Soc. Interface (2013) 10\, 20130684.\n3 A. Aguirre et al. European Cells and Materials Vol. 24 2012 (pages 90-106). \n 
URL:https://ibecbarcelona.eu/event/phd-discussion-session-ana-maria-solorzano-and-joan-marti-munoz-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T100000
DTEND;TZID=UTC:20160122T110000
DTSTAMP:20260426T114000
CREATED:20151027T094305Z
LAST-MODIFIED:20160118T081841Z
UID:19437-1453456800-1453460400@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Ana María Solórzano and Joan Martí Muñoz
DESCRIPTION:Carbon Monoxide Poisoning: Societal Impact\, Physiological Mechanism and Associated Chemical Instrumentation\nAna María Solórzano\, Signal and information processing for sensing systems group\nThe hazardousness of carbon monoxide is based on the inability of humans to detect it. Carbon monoxide is not irritating and has no color\, odor or either taste. The exposure to this gas can starve critical body organs specially vital organs like brain and heart. \nThe study and analysis of CO poisoning is not new. Even though in the last decades the society has been raised awareness on CO hazard\, accidental deaths are still produced by exposure to this gas. \nThe health effects of the CO poisoning depend on its concentration and time exposure. Health problems are noticeable with concentrations since 0.01% (100ppm).; this is the reason that the medical Instrumentation is an essential tool for the detection of CO. There is a kind of instrumentation\, which detects CO in the bloodstream\, and in the atmosphere but the early detection of this compound still is a challenge. \nWe are exploring how multi gas sensor arrays can be an effective solution to detect CO faster than typical alarms. \n  \nCalcium releasing ormoglass coated PLA nanofibers: A new approach for bone regeneration\nJoan Martí Muñoz\, Biomaterials for regenerative therapies group\nBone fracture healing has become a serious problem in the last decades in part due to the increase in life expectancy (1). The use of strategies that help body to restore bone are needed to increase the quality life of people suffering this problem. Among this strategies\, the use of natural sources such as; bone\, growth factors and other biomolecules has become an efficient option\, but present some limitations like money cost\, amount limitation and storage\, extra surgeries\, rejection and possible disease transmission (1). \nThe use of synthetic materials can be an effective option. However they need to be tuned to include the proper bioactive signals. Hybrid materials are and interesting alternative. Their organic phase\, normally a biodegradable biopolymer\, holds the mechanical stress while their inorganic phase\, a glass or ceramic\, provides the needed bioactivity to recruit cells and produce bone. In many cases\, the masking of the bioactive inorganic phase embedded in the organic matrix and undesired phase-detachments must be solved to increase efectiveness (2). Another limitation is the poor vascularization that synthetic materials induce. \nPrevious studies in our group demonstrated that extracellular Ca2+ release can promote angiogenesis (3). Here we present two different strategies: the first one consisting in CaP Ti-doped degradable ormoglass nanoparticles embedded inside polylactic acid (PLA) electrospun bioresorbable nanofibers; the second one consisting in CaP Si-doped degradable ormoglass nanoparticles (2) covalently attached on the surface of PLA electrospun nanofibers. In both cases the Ca2+ release by the ormoglass nanoparticles may activate the proper cell responses while the polymer provides the needed support to hold the particles and allow tissue growth. In the second case the attempt is to solve nanoparticle masking and detachment. \n1 M. Navarro et al. J. R. Soc. Interface (2008) 5\, 1137-1158.\n2 N. Sachot et al. J. R. Soc. Interface (2013) 10\, 20130684.\n3 A. Aguirre et al. European Cells and Materials Vol. 24 2012 (pages 90-106). \n 
URL:https://ibecbarcelona.eu/event/phd-discussion-session-ana-maria-solorzano-and-joan-marti-munoz/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151218T110000
DTEND;TZID=UTC:20151218T130000
DTSTAMP:20260426T114000
CREATED:20151126T134551Z
LAST-MODIFIED:20151126T134551Z
UID:95883-1450436400-1450443600@ibecbarcelona.eu
SUMMARY:PhD Defence: Aitor Sánchez
DESCRIPTION:“Biomimetic hydrogels for in situ bone tissue engineering. Nature-inspired crosslinking methods as a tool to tune scaffold physical properties”\nAitor Sánchez\, Biomaterials for Regenerative Therapies group\nAitor will be defending his PhD thesis on Friday 18th December at 11:00 in the Sala d’Actes\, Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-defence-aitor-sanchez-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151218T110000
DTEND;TZID=UTC:20151218T130000
DTSTAMP:20260426T114000
CREATED:20151126T134551Z
LAST-MODIFIED:20151126T134551Z
UID:19884-1450436400-1450443600@ibecbarcelona.eu
SUMMARY:PhD Defence: Aitor Sánchez
DESCRIPTION:“Biomimetic hydrogels for in situ bone tissue engineering. Nature-inspired crosslinking methods as a tool to tune scaffold physical properties”\nAitor Sánchez\, Biomaterials for Regenerative Therapies group\nAitor will be defending his PhD thesis on Friday 18th December at 11:00 in the Sala d’Actes\, Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-defence-aitor-sanchez/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151217T190000
DTEND;TZID=UTC:20151217T190000
DTSTAMP:20260426T114000
CREATED:20151130T155937Z
LAST-MODIFIED:20151209T073011Z
UID:19901-1450378800-1450378800@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2015
DESCRIPTION:We’re delighted to invite all IBECers to the biggest\, best IBEC Christmas Party Ever! \nThis year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. If you take part\, you’ll be in with a chance of winning a fabulous prize provided by our sponsors\, such as a food hamper\, a digital camera\, a tablet\, or a weekend break. If you’d like to suggest your favourite charity to be a beneficiary of this fundraising\, fill in the form in i-Box in the intranet (deadline 9th December)). \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises to be a fabulous way to kick-start the festive season!\n\nRegistration here.
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2015/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151217T190000
DTEND;TZID=UTC:20151217T190000
DTSTAMP:20260426T114000
CREATED:20151130T155937Z
LAST-MODIFIED:20151130T155937Z
UID:95884-1450378800-1450378800@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2015
DESCRIPTION:We’re delighted to invite all IBECers to the biggest\, best IBEC Christmas Party Ever! \nThis year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. If you take part\, you’ll be in with a chance of winning a fabulous prize provided by our sponsors\, such as a food hamper\, a digital camera\, a tablet\, or a weekend break. If you’d like to suggest your favourite charity to be a beneficiary of this fundraising\, fill in the form in i-Box in the intranet (deadline 9th December)). \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises to be a fabulous way to kick-start the festive season!\n\nRegistration here.
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2015-2/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151211T120000
DTEND;TZID=UTC:20151211T130000
DTSTAMP:20260426T114000
CREATED:20151029T093053Z
LAST-MODIFIED:20151029T093053Z
UID:19457-1449835200-1449838800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Roberto de la Rica
DESCRIPTION:Bioplasmonics in nanofabrication\, biosensing and nanomedicine\nRoberto de la Rica\, University of Strathclyde\nIn this talk I will show several bio-enabled and bio-inspired approaches for growing and assembling plasmonic nanoparticles and their applications in biosensing and nanomedicine. I will explain how to use enzyme nanoreactors to guide the growth of plasmonic nanoparticles with different morphologies\, an approach that can be used to design ultrasensitive biosensors and new nanolithography tools. [1-4] \nI will also show a method for assembling nanoparticle superstructures with crystallographically aligned building blocks5 that possess improved plasmonic properties derived from their 3D organization. When assembled on magnetic supports these plasmonic superstructures can be used for as multifunctional intracellular sensors as well as for heat generation in thermal therapy. \n[1] Nat. Mater. 11\, 604 (2012);[2] Nat. Nanotechnol. 7\, 821\, 2012; [3] Nat. Protocol. 8\, 1759 (2013); [4] Adv. Funct. Mater. 24\, 3692 (2104); [5] JACS 133\, 2875 (2011)
URL:https://ibecbarcelona.eu/event/ibec-seminar-roberto-de-la-rica/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151211T120000
DTEND;TZID=UTC:20151211T130000
DTSTAMP:20260426T114000
CREATED:20151029T093053Z
LAST-MODIFIED:20151029T093053Z
UID:95876-1449835200-1449838800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Roberto de la Rica
DESCRIPTION:Bioplasmonics in nanofabrication\, biosensing and nanomedicine\nRoberto de la Rica\, University of Strathclyde\nIn this talk I will show several bio-enabled and bio-inspired approaches for growing and assembling plasmonic nanoparticles and their applications in biosensing and nanomedicine. I will explain how to use enzyme nanoreactors to guide the growth of plasmonic nanoparticles with different morphologies\, an approach that can be used to design ultrasensitive biosensors and new nanolithography tools. [1-4] \nI will also show a method for assembling nanoparticle superstructures with crystallographically aligned building blocks5 that possess improved plasmonic properties derived from their 3D organization. When assembled on magnetic supports these plasmonic superstructures can be used for as multifunctional intracellular sensors as well as for heat generation in thermal therapy. \n[1] Nat. Mater. 11\, 604 (2012);[2] Nat. Nanotechnol. 7\, 821\, 2012; [3] Nat. Protocol. 8\, 1759 (2013); [4] Adv. Funct. Mater. 24\, 3692 (2104); [5] JACS 133\, 2875 (2011)
URL:https://ibecbarcelona.eu/event/ibec-seminar-roberto-de-la-rica-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151209T110000
DTEND;TZID=UTC:20151209T130000
DTSTAMP:20260426T114000
CREATED:20151117T133654Z
LAST-MODIFIED:20151117T133811Z
UID:19772-1449658800-1449666000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Ernest Moles
DESCRIPTION:“Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy”\nErnest Moles\, Nanomalaria joint unit\nErnest will be defending his PhD thesis on Wednesday 9th December at 11:00 in the Aula Magna of the Faculty of Pharmacy\, University of Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ernest-moles/
LOCATION:Aula Magna\, Faculty of Pharmacy\, Av. Joan XXIII s/n\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151209T110000
DTEND;TZID=UTC:20151209T130000
DTSTAMP:20260426T114000
CREATED:20151117T133654Z
LAST-MODIFIED:20151117T133654Z
UID:95880-1449658800-1449666000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Ernest Moles
DESCRIPTION:“Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy”\nErnest Moles\, Nanomalaria joint unit\nErnest will be defending his PhD thesis on Wednesday 9th December at 11:00 in the Aula Magna of the Faculty of Pharmacy\, University of Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ernest-moles-2/
LOCATION:Aula Magna\, Faculty of Pharmacy\, Av. Joan XXIII s/n\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151203T100000
DTEND;TZID=UTC:20151203T230000
DTSTAMP:20260426T114000
CREATED:20151126T075237Z
LAST-MODIFIED:20151126T075237Z
UID:95882-1449136800-1449183600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alexandre Perera
DESCRIPTION:Data evaluation in Metabolomics\, preprocessing\, analysis and biological enrichment\nAlexandre Perera\, B2SLab Bioinformatics and Biomedical Signals Laboratory\, UPC\nThis talk will depict the last efforts by the B2Slab on the processing of LC/MS metabolomics data. First\, we describe a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which intensity drift effects are modelled through Common Principal Components Analysis and removed from original data. Secondly\, we propose a new processing workflow based on peak aggregation techniques. We show that the predictive power of the data is improved when the peak aggregation techniques are used regardless of the prediction technique used. We also describe a new computational tool to perform end-to-end analysis (MAIT) coded under the R environment. MAIT package is highly modular and programmable which allow the users to perform their personalised LC/MS data analysis workflows. MAIT is able to take the raw output files from an LC/MS instrument as an input and\, by applying a set of functions\, provide a metabolite identification table as a result. Finally\, we introduce FELLA\, a set of algorithms for biological interpretation of metabolomic data in light of existing knowledge extracted from annotation databases\, extending the concept of pathway enrichment into metabolomics. FELLA is based on diffusion process on a graph representation of a knowledge base\, while statistically testing solutions against analytical null diffusion distributions. Results are provided comparing the tools with sate of the art methods on different network types.\n\n[1] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. Peak Aggregation as an Innovative Strategy for Improving the Predictive Power of LC-MS Metabolomic Profiles. Analytical Chemistry 86 (5)\, 2320–5 (2014).\n[2] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit). Bioinformatics 30(13):1937-9 (2014).\n[3] Fernández-Albert F.\, Llorach R.\, Garcia-Aloy M\, Ziyatdinov A\, Andrés-Lacueva C.\, Perera-Lluna A. Intensity drift removal in LC/MS metabolomics by Common Variance Compensation. Bioinformatics 30(20)\, 2898-2905 (2014)\n[4] Domingo-Almenara\, X.\, Perera\, A.\, Ramírez\, N.\, Cañellas\, N.\, Correig\, X.\, & Brezmes\, J. (2015). Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. Journal of Chromatography A\, 1409\, 226-233\n[5] Ziyatdinov\, A.; Marco\, S.; Chaudry\, A.; Persaud\, K.; Caminal\, P.; Perera\, A. Drift compensation of gas sensor array data by common principal component analysis. Sensors and Actuators B: Chemical 146\, 460-5 (2010).
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandre-perera-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151203T100000
DTEND;TZID=UTC:20151203T230000
DTSTAMP:20260426T114000
CREATED:20151126T075237Z
LAST-MODIFIED:20151126T075237Z
UID:19883-1449136800-1449183600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alexandre Perera
DESCRIPTION:Data evaluation in Metabolomics\, preprocessing\, analysis and biological enrichment\nAlexandre Perera\, B2SLab Bioinformatics and Biomedical Signals Laboratory\, UPC\nThis talk will depict the last efforts by the B2Slab on the processing of LC/MS metabolomics data. First\, we describe a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which intensity drift effects are modelled through Common Principal Components Analysis and removed from original data. Secondly\, we propose a new processing workflow based on peak aggregation techniques. We show that the predictive power of the data is improved when the peak aggregation techniques are used regardless of the prediction technique used. We also describe a new computational tool to perform end-to-end analysis (MAIT) coded under the R environment. MAIT package is highly modular and programmable which allow the users to perform their personalised LC/MS data analysis workflows. MAIT is able to take the raw output files from an LC/MS instrument as an input and\, by applying a set of functions\, provide a metabolite identification table as a result. Finally\, we introduce FELLA\, a set of algorithms for biological interpretation of metabolomic data in light of existing knowledge extracted from annotation databases\, extending the concept of pathway enrichment into metabolomics. FELLA is based on diffusion process on a graph representation of a knowledge base\, while statistically testing solutions against analytical null diffusion distributions. Results are provided comparing the tools with sate of the art methods on different network types.\n\n[1] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. Peak Aggregation as an Innovative Strategy for Improving the Predictive Power of LC-MS Metabolomic Profiles. Analytical Chemistry 86 (5)\, 2320–5 (2014).\n[2] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit). Bioinformatics 30(13):1937-9 (2014).\n[3] Fernández-Albert F.\, Llorach R.\, Garcia-Aloy M\, Ziyatdinov A\, Andrés-Lacueva C.\, Perera-Lluna A. Intensity drift removal in LC/MS metabolomics by Common Variance Compensation. Bioinformatics 30(20)\, 2898-2905 (2014)\n[4] Domingo-Almenara\, X.\, Perera\, A.\, Ramírez\, N.\, Cañellas\, N.\, Correig\, X.\, & Brezmes\, J. (2015). Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. Journal of Chromatography A\, 1409\, 226-233\n[5] Ziyatdinov\, A.; Marco\, S.; Chaudry\, A.; Persaud\, K.; Caminal\, P.; Perera\, A. Drift compensation of gas sensor array data by common principal component analysis. Sensors and Actuators B: Chemical 146\, 460-5 (2010).
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandre-perera/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T120000
DTEND;TZID=UTC:20151127T130000
DTSTAMP:20260426T114000
CREATED:20151106T080207Z
LAST-MODIFIED:20151123T092950Z
UID:19561-1448625600-1448629200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Chia-Fu Chou
DESCRIPTION:Low-copy number biomolecular analysis with dielectrophoretic enrichment /trapping via molecular dam and plasmonic electrode nanogaps\nChia-Fu Chou\, Senior Research Fellow/Professor\, Institute of Physics\, Academia Sinica\, Taiwan\nNanoscale structures\, such as electrode nanogap and nanofluidic confinement\, given its simplicity in geometry\, nevertheless offer unique platforms for the study of molecular and cellular biophysics\, with the potential for bioanalytical applications [1-5]. For low-copy number molecule detection\, we developed two versatile analysis platforms for the manipulation and sensing of biomolecules. In the first scenario\, sub-30 nm insulating nanoconstriction operating under the balance of negative dielectrophoresis (DEP)\, electrophoresis\, and electroosmosis\, serves as molecular dam\, enables protein enrichment of 105-fold in 20 seconds [6]\, which can then be coupled with graphene-modified electrode for sensitive electrochemical detection of proteins and peptides [7\, 8]. In the second scenario\, an array of Ti/Au electrode nanogaps with sub-10 nm gap size function as templates for AC DEP-based molecular trapping\, plasmonic hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements\, and fluorescence imaging. During molecular trapping\, recorded Raman spectra\, conductance measurements across the nanogaps and fluorescence imaging show unambiguously the presence and characteristics of the trapped molecules\, demonstrated with R-phycoerythrin [9] and Alzheimer’s disease associated biomarkers A-beta 40 and 42 peptides. Our platforms open up simple ways for multifunctional low-concentration heterogeneous sample analysis.\n[1] L.J. Guo\, X. Cheng\, C.F. Chou\, Nano Lett. 4\, 69 (2004).\n[2] J. Gu\, R. Gupta\, C.F. Chou\, Q. Wei\, F. Zenhausern\, Lab Chip 7\, 1198 (2007).\n[3] J.W. Yeh\, A. Taloni\, Y.L. Chen\, C.F. Chou\, Nano Lett. 12\, 1597 (2012). [Research Highlights\, Nature 482\, 442 (2012)].\n[4] J.P. Shen and C.F. Chou\, Biomicrofluidics 8\, 041103 (2014).\n[5] K.K. Sriram\, J.W. Yeh\, Y.L. Lin\, Y.R. Chang\, C.F. Chou\, Nucleic Acids Res. 42\, e85 (2014).\n[6] K.T. Liao\, C.F. Chou\, J. Am. Chem. Soc. 134\, 8742 (2012). [JACS Spotlights: JACS 134\, 10307 (2012)]\n[7] B. Sanghavi\, W. Varhue\, J. Chávez\, C.F. Chou\, N. S. Swami\, Anal. Chem. 86\, 4120 (2014\,).\n[8] B.J. Sanghavi\, W. Varhue\, A. Rohani\, K.T. Liao\, L. Bazydlo\, C.F. Chou\, N. S. Swami\, Lab Chip 2015\, DOI: 10.1039/c5lc00840a.\n[9] L. Lesser-Rojas\, P. Ebbinghaus\, G. Vasan\, M.L. Chu\, A. Erbe\, C.F. Chou\, Nano Lett. 14\, 2242 (2014).
URL:https://ibecbarcelona.eu/event/ibec-seminar-chia-fu-chou/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T120000
DTEND;TZID=UTC:20151127T130000
DTSTAMP:20260426T114000
CREATED:20151106T080207Z
LAST-MODIFIED:20151106T080207Z
UID:95877-1448625600-1448629200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Chia-Fu Chou
DESCRIPTION:Low-copy number biomolecular analysis with dielectrophoretic enrichment /trapping via molecular dam and plasmonic electrode nanogaps\nChia-Fu Chou\, Senior Research Fellow/Professor\, Institute of Physics\, Academia Sinica\, Taiwan\nNanoscale structures\, such as electrode nanogap and nanofluidic confinement\, given its simplicity in geometry\, nevertheless offer unique platforms for the study of molecular and cellular biophysics\, with the potential for bioanalytical applications [1-5]. For low-copy number molecule detection\, we developed two versatile analysis platforms for the manipulation and sensing of biomolecules. In the first scenario\, sub-30 nm insulating nanoconstriction operating under the balance of negative dielectrophoresis (DEP)\, electrophoresis\, and electroosmosis\, serves as molecular dam\, enables protein enrichment of 105-fold in 20 seconds [6]\, which can then be coupled with graphene-modified electrode for sensitive electrochemical detection of proteins and peptides [7\, 8]. In the second scenario\, an array of Ti/Au electrode nanogaps with sub-10 nm gap size function as templates for AC DEP-based molecular trapping\, plasmonic hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements\, and fluorescence imaging. During molecular trapping\, recorded Raman spectra\, conductance measurements across the nanogaps and fluorescence imaging show unambiguously the presence and characteristics of the trapped molecules\, demonstrated with R-phycoerythrin [9] and Alzheimer’s disease associated biomarkers A-beta 40 and 42 peptides. Our platforms open up simple ways for multifunctional low-concentration heterogeneous sample analysis.\n[1] L.J. Guo\, X. Cheng\, C.F. Chou\, Nano Lett. 4\, 69 (2004).\n[2] J. Gu\, R. Gupta\, C.F. Chou\, Q. Wei\, F. Zenhausern\, Lab Chip 7\, 1198 (2007).\n[3] J.W. Yeh\, A. Taloni\, Y.L. Chen\, C.F. Chou\, Nano Lett. 12\, 1597 (2012). [Research Highlights\, Nature 482\, 442 (2012)].\n[4] J.P. Shen and C.F. Chou\, Biomicrofluidics 8\, 041103 (2014).\n[5] K.K. Sriram\, J.W. Yeh\, Y.L. Lin\, Y.R. Chang\, C.F. Chou\, Nucleic Acids Res. 42\, e85 (2014).\n[6] K.T. Liao\, C.F. Chou\, J. Am. Chem. Soc. 134\, 8742 (2012). [JACS Spotlights: JACS 134\, 10307 (2012)]\n[7] B. Sanghavi\, W. Varhue\, J. Chávez\, C.F. Chou\, N. S. Swami\, Anal. Chem. 86\, 4120 (2014\,).\n[8] B.J. Sanghavi\, W. Varhue\, A. Rohani\, K.T. Liao\, L. Bazydlo\, C.F. Chou\, N. S. Swami\, Lab Chip 2015\, DOI: 10.1039/c5lc00840a.\n[9] L. Lesser-Rojas\, P. Ebbinghaus\, G. Vasan\, M.L. Chu\, A. Erbe\, C.F. Chou\, Nano Lett. 14\, 2242 (2014).
URL:https://ibecbarcelona.eu/event/ibec-seminar-chia-fu-chou-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T100000
DTEND;TZID=UTC:20151127T110000
DTSTAMP:20260426T114000
CREATED:20151027T093619Z
LAST-MODIFIED:20151119T152104Z
UID:19436-1448618400-1448622000@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Maria Chiara Biagi and Roger Oria
DESCRIPTION:Nanoscale dielectric characterization of single bacterial cells at microwave frequency\nMaria Chiara Biagi\, Nanoscale Bioelectrical Characterization group\nInformation on the microwave electromagnetic properties of cell suspensions and tissues has already led to important application in therapeutic and diagnostic. In recent years\, a new microscopy technique has appeared\, able to resolve the electromagnetic response at GHz even further down\, at nanoscale spatial resolution: Scanning Microwave Microscope (SMM). Its application to single cells would possibly allow not just to scale down the existing medical and biological techniques\, but would also give rise to a new class of label-free imaging methods based on dielectric contrast. Yet\, the quantification of the intrinsic dielectric properties (i.e. complex permittivity) of non-planar irregular shaped objects like single cells from the standard SMM images remains a challenge\, because the experimental signal is greatly affected by the huge presence of non-local contributions. \nWe developed a methodology to quantify and remove them\, which consequently enables to obtain images related only to the intrinsic dielectric response of the sample. These images are then suitable for a quantitative analysis and\, in combination with 3D finite element numerical calculations\, a map of the complex permittivity of the cell can be obtained.\nWe have applied this procedure to a single bacterial cell (E. coli) and quantified for the first time its complex permittivity at ~19 GHz\, in dry and humid conditions. \n  \nInterplay between integrin expression\, clustering\, and substrate rigidity in cell mechanical response\nRoger Oria\, Cellular and respiratory biomechanics group\nEssential cell functions such as proliferation\, differentiation\, or migration are determined by the rigidity and composition of the extracellular matrix (ECM). Understanding this interaction requires a precise control of ECM mechanical properties and molecular distribution of cell-ECM ligands\, as well as the ability to measure the mechanical forces transmitted at the cell-ECM interface. To address this issue\, we have developed an approach based on polyacrylamide substrates of tunable rigidity decorated with nanometric regular hexagonal patterns of RGD ligands\, which serve as binding sites for single integrins. By using this system\, we have systematically analysed cell response in terms of force transmission\, rearward flow and integrin recruitment after varying (i) gel rigidity\, (ii) spacing and spatial distribution between RGD ligands\, and (iii) integrin expression levels. Our results show that cell response and force generation are critically dependent on all factors. We also demonstrate the counter-intuitive fact that at specific ECM rigidities cells increase force transmission as the spacing between integrins increases from 50 to 100 nm. Our findings indicate that mechanical homeostasis can be tuned by cells using strategies based on integrin expression\, clustering of ECM ligands\, or ECM rigidity\, and that an in-depth understanding of cell mechanical responses requires the consideration of all those factors. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-session-maria-chiara-and-roger-oria/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T100000
DTEND;TZID=UTC:20151127T110000
DTSTAMP:20260426T114000
CREATED:20151027T093619Z
LAST-MODIFIED:20151027T093619Z
UID:95874-1448618400-1448622000@ibecbarcelona.eu
SUMMARY:PhD Discussions Session: Maria Chiara Biagi and Roger Oria
DESCRIPTION:Nanoscale dielectric characterization of single bacterial cells at microwave frequency\nMaria Chiara Biagi\, Nanoscale Bioelectrical Characterization group\nInformation on the microwave electromagnetic properties of cell suspensions and tissues has already led to important application in therapeutic and diagnostic. In recent years\, a new microscopy technique has appeared\, able to resolve the electromagnetic response at GHz even further down\, at nanoscale spatial resolution: Scanning Microwave Microscope (SMM). Its application to single cells would possibly allow not just to scale down the existing medical and biological techniques\, but would also give rise to a new class of label-free imaging methods based on dielectric contrast. Yet\, the quantification of the intrinsic dielectric properties (i.e. complex permittivity) of non-planar irregular shaped objects like single cells from the standard SMM images remains a challenge\, because the experimental signal is greatly affected by the huge presence of non-local contributions. \nWe developed a methodology to quantify and remove them\, which consequently enables to obtain images related only to the intrinsic dielectric response of the sample. These images are then suitable for a quantitative analysis and\, in combination with 3D finite element numerical calculations\, a map of the complex permittivity of the cell can be obtained.\nWe have applied this procedure to a single bacterial cell (E. coli) and quantified for the first time its complex permittivity at ~19 GHz\, in dry and humid conditions. \n  \nInterplay between integrin expression\, clustering\, and substrate rigidity in cell mechanical response\nRoger Oria\, Cellular and respiratory biomechanics group\nEssential cell functions such as proliferation\, differentiation\, or migration are determined by the rigidity and composition of the extracellular matrix (ECM). Understanding this interaction requires a precise control of ECM mechanical properties and molecular distribution of cell-ECM ligands\, as well as the ability to measure the mechanical forces transmitted at the cell-ECM interface. To address this issue\, we have developed an approach based on polyacrylamide substrates of tunable rigidity decorated with nanometric regular hexagonal patterns of RGD ligands\, which serve as binding sites for single integrins. By using this system\, we have systematically analysed cell response in terms of force transmission\, rearward flow and integrin recruitment after varying (i) gel rigidity\, (ii) spacing and spatial distribution between RGD ligands\, and (iii) integrin expression levels. Our results show that cell response and force generation are critically dependent on all factors. We also demonstrate the counter-intuitive fact that at specific ECM rigidities cells increase force transmission as the spacing between integrins increases from 50 to 100 nm. Our findings indicate that mechanical homeostasis can be tuned by cells using strategies based on integrin expression\, clustering of ECM ligands\, or ECM rigidity\, and that an in-depth understanding of cell mechanical responses requires the consideration of all those factors. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-session-maria-chiara-and-roger-oria-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151123T150000
DTEND;TZID=UTC:20151123T170000
DTSTAMP:20260426T114000
CREATED:20151119T115401Z
LAST-MODIFIED:20151119T115612Z
UID:19829-1448290800-1448298000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Lorena De Oñate
DESCRIPTION:“Research on cardiac differentiation from human pluripotent stem cells: how to get beating cells in a dish”\nLorena De Oñate\, Pluripotent Stem Cells and Activation of Endogenous Tissue Programs for Organ Regeneration group\nLorena will be defending her PhD thesis on Monday 23rd November at 15:00 in the Ramón y Cajal Room at the Parc de Recerca Biomèdica (PRBB).  \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lorena-de-onate/
LOCATION:Sala Ramón y Cajal\, Parc de Recerca Biomèdica (PRBB)\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151123T150000
DTEND;TZID=UTC:20151123T170000
DTSTAMP:20260426T114000
CREATED:20151119T115401Z
LAST-MODIFIED:20151119T115401Z
UID:95881-1448290800-1448298000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Lorena De Oñate
DESCRIPTION:“Research on cardiac differentiation from human pluripotent stem cells: how to get beating cells in a dish”\nLorena De Oñate\, Pluripotent Stem Cells and Activation of Endogenous Tissue Programs for Organ Regeneration group\nLorena will be defending her PhD thesis on Monday 23rd November at 15:00 in the Ramón y Cajal Room at the Parc de Recerca Biomèdica (PRBB).  \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lorena-de-onate-2/
LOCATION:Sala Ramón y Cajal\, Parc de Recerca Biomèdica (PRBB)\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151119T120000
DTEND;TZID=UTC:20151119T130000
DTSTAMP:20260426T114000
CREATED:20151109T154810Z
LAST-MODIFIED:20151113T074152Z
UID:19587-1447934400-1447938000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Luis de Lecea
DESCRIPTION:Optogenetic control of arousal\nLuis de Lecea\, Department of Psychiatry and Behavioral Sciences\, Stanford University School of Medicine\nChanges in arousal states are at the core of most neuropsychiatric disorders. Several groups of monoaminergic neurons have long been known to facilitate arousal state transitions. Here we will review the role of hypocretin/orexin neurons in the dynamics of sleep-to-wake transitions. I will also show data demonstrating that dopaminergic neurons of the ventral tegmental area (VTA) directly and causally control the generation and maintenance of electrocortical and behavioral arousal. Combining chemogenetic and optogenetic tools with polysomnographic recordings in mice\, we show that activity in VTA-dopaminergic neurons is necessary for arousal\, and that their chemogenetic inhibition suppresses wakefulness to promote both non-rapid eye movement (NREM) and REM sleep. Moreover\, chemogenetic inhibition of VTA-dopaminergic neurons suppresses wakefulness even in the face of highly salient stimuli related to reproduction\, feeding and predation. Nevertheless\, prior to inducing sleep\, chemogenetic inhibition of VTA-dopaminergic neurons promotes goal-directed and sleep-related nest building behavior. Optogenetic stimulation\, in contrast\, initiates and maintains long-term wakefulness and suppresses sleep and sleep-related nesting behavior. We further show that the nucleus accumbens (NAc) circuit\, and not the medial prefrontal cortex (mPFC)\, mediates most of VTA-dopaminergic effects on arousal. After collecting data from multiple brain structures involved in arousal states\, we propose a computational model that assigns probabilities to optogenetically-induced arousal state transitions in individual brain structures. We identify feedback\, redundancy\, and gating hierarchy as three fundamental aspects of this model. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into arousal state dynamics as well as arousal-related disorders.
URL:https://ibecbarcelona.eu/event/ibec-seminar-luis-de-lecea/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151119T120000
DTEND;TZID=UTC:20151119T130000
DTSTAMP:20260426T114000
CREATED:20151109T154810Z
LAST-MODIFIED:20151109T154810Z
UID:95878-1447934400-1447938000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Luis de Lecea
DESCRIPTION:Optogenetic control of arousal\nLuis de Lecea\, Department of Psychiatry and Behavioral Sciences\, Stanford University School of Medicine\nChanges in arousal states are at the core of most neuropsychiatric disorders. Several groups of monoaminergic neurons have long been known to facilitate arousal state transitions. Here we will review the role of hypocretin/orexin neurons in the dynamics of sleep-to-wake transitions. I will also show data demonstrating that dopaminergic neurons of the ventral tegmental area (VTA) directly and causally control the generation and maintenance of electrocortical and behavioral arousal. Combining chemogenetic and optogenetic tools with polysomnographic recordings in mice\, we show that activity in VTA-dopaminergic neurons is necessary for arousal\, and that their chemogenetic inhibition suppresses wakefulness to promote both non-rapid eye movement (NREM) and REM sleep. Moreover\, chemogenetic inhibition of VTA-dopaminergic neurons suppresses wakefulness even in the face of highly salient stimuli related to reproduction\, feeding and predation. Nevertheless\, prior to inducing sleep\, chemogenetic inhibition of VTA-dopaminergic neurons promotes goal-directed and sleep-related nest building behavior. Optogenetic stimulation\, in contrast\, initiates and maintains long-term wakefulness and suppresses sleep and sleep-related nesting behavior. We further show that the nucleus accumbens (NAc) circuit\, and not the medial prefrontal cortex (mPFC)\, mediates most of VTA-dopaminergic effects on arousal. After collecting data from multiple brain structures involved in arousal states\, we propose a computational model that assigns probabilities to optogenetically-induced arousal state transitions in individual brain structures. We identify feedback\, redundancy\, and gating hierarchy as three fundamental aspects of this model. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into arousal state dynamics as well as arousal-related disorders.
URL:https://ibecbarcelona.eu/event/ibec-seminar-luis-de-lecea-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151118T171500
DTEND;TZID=UTC:20151118T203000
DTSTAMP:20260426T114000
CREATED:20151110T131625Z
LAST-MODIFIED:20151110T131625Z
UID:95879-1447866900-1447878600@ibecbarcelona.eu
SUMMARY:Setmana de la Ciència 2015
DESCRIPTION:Setmana de la Ciència 2015\nParc Científic de Barcelona\, Sala Dolors Aleu\nEl dimecres 18 de novembre a la tarda\, en el context de la celebració de la SETMANA DE LA CIÈNCIA\, volem que ens acompanyis en una jornada científica singular. \nPodràs visitar els laboratoris per conèixer la recerca més puntera en bioenginyeria\, i sota el títol “Fem visibles les forces cel·lulars”\, el Professor Xavier Trepat explicarà com i perquè estudien les forces que fan les cèl·lules. \nA més a més\, per celebrar que aquest any és l’Any Internacional de la llum\, finalitzarem la visita amb un brindis i un petit concert amb inspiració científica.\nAquesta activitat és gratuïta\, està dirigida a majos de 16 anys i les places són limitades\, per tant cal INSCRIURE’S
URL:https://ibecbarcelona.eu/event/setmana-de-la-ciencia-2015-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151118T171500
DTEND;TZID=UTC:20151118T203000
DTSTAMP:20260426T114000
CREATED:20151110T131625Z
LAST-MODIFIED:20170801T131002Z
UID:19592-1447866900-1447878600@ibecbarcelona.eu
SUMMARY:Setmana de la Ciència 2015
DESCRIPTION:Setmana de la Ciència 2015\nParc Científic de Barcelona\, Sala Dolors Aleu\nEl dimecres 18 de novembre a la tarda\, en el context de la celebració de la SETMANA DE LA CIÈNCIA\, volem que ens acompanyis en una jornada científica singular. \nPodràs visitar els laboratoris per conèixer la recerca més puntera en bioenginyeria\, i sota el títol “Fem visibles les forces cel·lulars”\, el Professor Xavier Trepat explicarà com i perquè estudien les forces que fan les cèl·lules. \nA més a més\, per celebrar que aquest any és l’Any Internacional de la llum\, finalitzarem la visita amb un brindis i un petit concert amb inspiració científica.\nAquesta activitat és gratuïta\, està dirigida a majos de 16 anys i les places són limitades\, per tant cal INSCRIURE’S
URL:https://ibecbarcelona.eu/event/setmana-de-la-ciencia-2015/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151111T110000
DTEND;TZID=UTC:20151111T130000
DTSTAMP:20260426T114000
CREATED:20151021T082429Z
LAST-MODIFIED:20151021T082429Z
UID:19399-1447239600-1447246800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense:  Rosa Letizia Zaffino
DESCRIPTION:“Development of a nano-sensor for the direct electrical free-label detection of DNA’s hybridisation and single nucleotide polymorphism”\nRosa Letizia Zaffino\, Nanobioengineering group\nRosa will be defending her PhD thesis on Wednesday 11th November at 11:00 in the Sala de Grados (A01S)\, Faculty of Physics.  \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-rosa-letizia-zaffino/
LOCATION:Sala de Grados (A01S)\, Faculty of Physics\, UB\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151111T110000
DTEND;TZID=UTC:20151111T130000
DTSTAMP:20260426T114000
CREATED:20151021T082429Z
LAST-MODIFIED:20151021T082429Z
UID:95873-1447239600-1447246800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense:  Rosa Letizia Zaffino
DESCRIPTION:“Development of a nano-sensor for the direct electrical free-label detection of DNA’s hybridisation and single nucleotide polymorphism”\nRosa Letizia Zaffino\, Nanobioengineering group\nRosa will be defending her PhD thesis on Wednesday 11th November at 11:00 in the Sala de Grados (A01S)\, Faculty of Physics.  \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-rosa-letizia-zaffino-2/
LOCATION:Sala de Grados (A01S)\, Faculty of Physics\, UB\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151027T113000
DTEND;TZID=UTC:20151027T133000
DTSTAMP:20260426T114000
CREATED:20151021T064210Z
LAST-MODIFIED:20151021T064210Z
UID:19388-1445945400-1445952600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Andrés Arcentales Viteri
DESCRIPTION:“Análisis de la interacción cardíaca y respiratoria en pacientes con cardiomiopatía y pacientes en proceso de extubación”\nAndrés Arcentales Viteri\, Biomedical Signal Processing and Interpretation group\nAndrés will be defending his PhD thesis on Tuesday 27th October at 11:30 in the Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona.  \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-andres-arcentales-viteri/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151027T113000
DTEND;TZID=UTC:20151027T133000
DTSTAMP:20260426T114000
CREATED:20151021T064210Z
LAST-MODIFIED:20151021T064210Z
UID:95872-1445945400-1445952600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Andrés Arcentales Viteri
DESCRIPTION:“Análisis de la interacción cardíaca y respiratoria en pacientes con cardiomiopatía y pacientes en proceso de extubación”\nAndrés Arcentales Viteri\, Biomedical Signal Processing and Interpretation group\nAndrés will be defending his PhD thesis on Tuesday 27th October at 11:30 in the Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, 08028 Barcelona.  \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-andres-arcentales-viteri-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20151023T100000
DTEND;TZID=Europe/Madrid:20151023T110000
DTSTAMP:20260426T114000
CREATED:20150803T123423Z
LAST-MODIFIED:20150803T123423Z
UID:95866-1445594400-1445598000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Miquel Bosch Pita
DESCRIPTION:The molecular mechanisms of memory persistence: imaging how single synapses learn in real time\nMiquel Bosch Pita\, Nanoprobes and nanoswitches group\, IBEC\nMemories are stored in our brain through the ability of synaptic connections to modify their structure and function in a long-lasting way. However\, nobody has ever observed how these changes occur in a single synapse in real time.\nI will explain how we used a new combination of optical technologies to reveal the molecular remodeling that takes place inside a synapse during the creation of a memory. We used two-photon microscopy to stimulate individual synapses and to visualize protein trafficking in real time. We identified a unique protein that is rapidly and persistently captured in potentiated synapses\, forming a new macromolecule that could serve as a memory tag. We developed a novel photo-marking technique that allowed us to localize the same synapses under both two-photon and electron microscopies. This way we observed how different synaptic structures evolve asynchronously in three temporal phases during synaptic potentiation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-miquel-bosch-pita-2/
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR