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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230206T080000
DTEND;TZID=Europe/Madrid:20230207T170000
DTSTAMP:20260403T211411
CREATED:20221202T105931Z
LAST-MODIFIED:20221202T105931Z
UID:102311-1675670400-1675789200@ibecbarcelona.eu
SUMMARY:Transdisciplinary Approaches for Neuroblastoma therapy symposium
DESCRIPTION:This networking event brings together experts from different fields but with the same objective- to join forces to fight NB and accelerate new treatments discovery. To this end\, the main aim of the networking event is to share knowledge on Neuroblastoma between physicians\, researchers\, and members of patient advocacy organizations\, and build up a research consortium to actively participate in the Europe’s Beating Cancer Plan. \nThe symposium will be held at the Sant Joan de Deu Hospital in the greater Barcelona area (Spain); it will be carried out in four sessions to discuss new advancements in Neuroblastoma characterization and modeling\, cutting-edge technologies\, and current strategies for Neurblastoma therapy. \nThe network event will serve to bring knowledge for all participants\, build up new research networks\, and disseminate the event conclusions to the general public\, thanks to the support of the Association of Families and Friends of Children with Neuroblastoma (NEN). \nThe symposium encourages the participation of Early Career Researchers and enables involvement in the network of usually underrepresented countries in Europe. \nProgramme and registration here.
URL:https://ibecbarcelona.eu/event/transdisciplinary-approaches-for-neuroblastoma-therapy-symposium/
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230217T100000
DTEND;TZID=Europe/Madrid:20230217T120000
DTSTAMP:20260403T211411
CREATED:20230202T144717Z
LAST-MODIFIED:20230202T144717Z
UID:103953-1676628000-1676635200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Presentation of the new Programme of ”la Caixa” Foundation on Innovation in Biomedicine and Health
DESCRIPTION:Alexandre Esteban\, Programme Manager at ”la Caixa” Foundation\nDuring the event\, all the details of the new Innovation programme will be presented\, with which the “la Caixa” Foundation reinforces its commitment to innovation and knowledge transfer in Spain and Portugal. \nThis new programme will fund breakthrough technologies with high market potential.
URL:https://ibecbarcelona.eu/event/ibec-seminar-presentation-of-the-new-programme-of-la-caixa-foundation-on-innovation-in-biomedicine-and-health/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230217T150000
DTEND;TZID=Europe/Madrid:20230217T170000
DTSTAMP:20260403T211411
CREATED:20230208T150410Z
LAST-MODIFIED:20230208T150410Z
UID:104133-1676646000-1676653200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Madhura Murar
DESCRIPTION:Peptide functionalized polymeric nanocarriers: Towards selective targeting of prostate cancer\n\n\n\n\nAuthor: Madhura Vijay Murar\, nanoscopy for nanomedicine\n\nThis thesis defence will take place at “Aula Magna” Faculty of Physics\,\n\nUniversity of Barcelona (Carrer de Martí i Franquès\, 1\, 11\, 08028 Barcelona) at 15:00 \n\nYou can join online to see the defense in the following link. \n\n\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-madhura-murar/
LOCATION:Aula Magna\, Faculty of Physics\, UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230228T103000
DTEND;TZID=Europe/Madrid:20230228T123000
DTSTAMP:20260403T211411
CREATED:20230223T124019Z
LAST-MODIFIED:20230223T124142Z
UID:104674-1677580200-1677587400@ibecbarcelona.eu
SUMMARY:NANO RARE DISEASES DAY (Event in Spanish)
DESCRIPTION:El Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapias. \nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \n\n\n\n\n\n\n\n\n\n\nRegistro aquí.
URL:https://ibecbarcelona.eu/event/nano-rare-diseases-day-event-in-spanish/
LOCATION:Hospital Sant Joan de Déu\, Pg. de Sant Joan de Déu\, 2\, Esplugues de Llobregat
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230303T100000
DTEND;TZID=Europe/Madrid:20230303T120000
DTSTAMP:20260403T211411
CREATED:20230222T091933Z
LAST-MODIFIED:20230227T120702Z
UID:104641-1677837600-1677844800@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills Session: Life at IBEC: Opportunities for PhD students
DESCRIPTION:Are you doing your PhD at IBEC? Do you know what you need to apply for the PhD Certificate of excellence or award? Do you know there are many different committees that you can join? Have you heard about the mentoring and training sessions that you can join? What about other mobility programmes? Would you like to participate in science education or outreach activities\, and you do not know who to talk to? Do you have any idea of how to proceed when you publish your first paper? \nAll these questions and many others will be answered in our next Complementary Skills session.  Come and learn with IBEC’s research management team and the IBEC PhD committee all the opportunities for PhDs that we offer at IBEC. \n  \nCarolina Mari and Arnau Fornell\, HR Department \nMaria Arista\, Communications Department \nCristina Arimany and Fidel Bellmunt\, Strategic Initiatives Department \nMiquel Bosch\, PhD Committee
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-session-life-at-ibec-opportunities-for-phd-students/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230307T173000
DTEND;TZID=Europe/Madrid:20230307T190000
DTSTAMP:20260403T211411
CREATED:20230124T141825Z
LAST-MODIFIED:20230223T124550Z
UID:103698-1678210200-1678215600@ibecbarcelona.eu
SUMMARY:Inauguració exposició laboratori de paisatges humans
DESCRIPTION:El Laboratorio de Paisatges Humans i la recerca artística\n\n\n\n\n\n“Laboratori de Paisatges Humans” és el resultat del procés creatiu portat a terme perla il·lustradora Roser Cussó durant la seva estada artística a l’Institut de Bioenginyeria de Catalunya (IBEC). \nLa imaginació i la ficció\, com a eines d’investigació\, ens ajuden a construir espais ficticis per dibuixar el que és invisible. Aquesta exposició mostra com la investigació artística troba nous punts de partida sobre els quals construir noves narratives. \nAquest projecte s’ha portat a terme amb una beca per a la recerca i la innovació en els àmbits de les arts visuals\, de l’arquitectura i el disseny\, de les arts escèniques\, de la música i del pensament\, atorgada de la Generalitat de Catalunya. \nAquesta exposició estarà oberta al públic fins al 28 de febrer. \n\n\n\n\nActe inaugural:\nDimecres 7 de març a les 17:30h · Parc Científic de Barcelona · Carrer Baldiri Reixac\, 4-8\nRegistre aquí.
URL:https://ibecbarcelona.eu/event/inauguracio-exposicio-laboratori-de-paisatges-humans/
LOCATION:Cluster II
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230310T090000
DTEND;TZID=Europe/Madrid:20230310T183000
DTSTAMP:20260403T211411
CREATED:20230223T124418Z
LAST-MODIFIED:20230223T124418Z
UID:104680-1678438800-1678473000@ibecbarcelona.eu
SUMMARY:2023 BIST Symposium on Microscopy\, Nanoscopy and Imaging Sciences
DESCRIPTION:The sixth edition of the BIST Symposium on Microscopy\, Nanoscopy and Imaging Sciences will take place on March 10\, 2023\, at Institute of Photonic Sciences (ICFO) \nThe event will include a series of talks and discussions featuring experts in various fields such as Optical Microscopy\, Electron Microscopy\, Scanning probe Microscopy\, Raman Imaging and Spectroscopy and Imaging Technology\, among others. \n  \nMore information here. \nRegister here. \n 
URL:https://ibecbarcelona.eu/event/2023-bist-symposium-on-microscopy-nanoscopy-and-imaging-sciences/
LOCATION:ICFO – Auditorium\, Mediterranean Technology Park\, Av. Carl Friedrich Gauss\, 3\,\, Castelldefels\, 08860
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230320T090000
DTEND;TZID=Europe/Madrid:20230321T130000
DTSTAMP:20260403T211411
CREATED:20230309T155242Z
LAST-MODIFIED:20230309T155242Z
UID:105696-1679302800-1679403600@ibecbarcelona.eu
SUMMARY:Barcelona Integrative Resonance Symposium
DESCRIPTION:Barcelona Integrative Resonance\nThe symposium aims to celebrate the strong magnetic resonance momentum in Barcelona and bring together the community working with this highly versatile technique in a plethora of different applications. Also\, it will represent the kick-off meeting upon the installation in Barcelona of three new magnetic resonance instruments: a GHz NMR\, a pulsed EPR-ENDOR\, and a MRI linked to hyperpolarization. \nThe NMR and EPR instruments will be part of the Scientific and Technological Centers of the University of Barcelona (CCiTUB). The Hyperpolarization-MRI instrument is part of the Institute for Bioengineering of Catalonia (IBEC) and is located next to the NMR instruments in the Barcelona Science Park. The 1 GHz NMR instrument is part of a Spanish Singular Scientific and Technological Infrastructure with nodes in Barcelona\, Bilbao and Madrid. \nThe new infrastructures witness the vitality of the magnetic resonance community. We want to emphasize by this joint celebration the importance of strengthening the connection between the diverse flavors of magnetic resonance\, as well as the different scientific fields and institutions. The list of speakers includes a nearly 50%-50% balance between consolidated scientific leaders and early career scientists that represent the bright future of magnetic resonance in Catalonia\, Spain and Europe.
URL:https://ibecbarcelona.eu/event/barcelona-integrative-resonance-symposium/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress,Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230331T100000
DTEND;TZID=Europe/Madrid:20230331T110000
DTSTAMP:20260403T211411
CREATED:20230322T104147Z
LAST-MODIFIED:20230322T111957Z
UID:106348-1680256800-1680260400@ibecbarcelona.eu
SUMMARY:PhD Discussions: José Muñoz-López
DESCRIPTION:Design and characterization of bifunctional hydrophilic Janus micelles\nJosé Muñoz-López\, Molecular Bionics Group \nJanus micelles are featured by their biphasic geometry of heterogeneous composition and distinctive properties in the core and corona. Such anisotropic design has attracted much attention from the scientific community due to the versatility of chemistries employed for generating Janus’ morphologies and their potential applications. In this work\, we present a novel ABC amphiphilic triblock copolymer system with the ability to form Janus micelles. The micelles are generated by solution-mediated self-assembly of the A and C hydrophilic\, and B hydrophobic blocks. Subsequently\, the hydrophilic blocks in the proposed triblock system will be functionalized with different and specific bioactive ligands to enable the constitution of multifunctional supramolecular scaffolds. The final aim of the project herein presented is to develop nanodrugs with well-defined dissimilar phenotypical domains\, in the same fashion as the asymmetric functionalisation of antibodies that already exist in nature\, to perform alike. To this end\, poly(ethylene glycol)-polylactide-poly(N-vinylpyrrolidone) PEG-PLA-PVP triblock copolymer was synthesised in two steps: first\, poly(ethylene glycol)-polylactide-2-bromo-2-methylpropanoate (PEG-PLA-Br) diblock macroinitiator was synthesized by the ring-opening polymerization of DL-lactide with commercial poly(ethylene glycol) and quenched with 2-bromo-isobutiryl-bromide. After that triblock copolymer was synthesized by the atom transfer radical polymerization (ATRP) of N-vinylpyrrolidone monomer (NVP) initiated by the PEG-PLA-Br diblock produced in the former synthetic step. The characterization of the produced diblock and triblock copolymers were carried out by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). Such techniques enabled us to verify the controlled radical polymerization of NVP and the complete conversion of PEG-PLA-Br diblock to the proposed PEG-PLA-PVP triblock. The morphologies adopted by PEG-PLA-Br and PEG-PLA-PVP in solution were investigated by transmission electron microscopy (TEM)\, confirming the formation of micelles for both block copolymers. TEM images showed differences in the negative stained micelles generated in the diblock and triblock copolymers systems. Such differences indicate the asymmetric distribution of both hydrophilic blocks\, PEG and PVP\, in the self-assembling of the PEG-PLA-PVP triblock system. Further structure characterizations will include atomic force microscopy (AFM)\, cryo-TEM\, electron energy loss spectroscopy (EELS)\, and ultimately the functionalization of both coronas with different targeting ligands. \n\n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-jose-munoz-lopez/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230413T150000
DTEND;TZID=Europe/Madrid:20230413T170000
DTSTAMP:20260403T211411
CREATED:20230328T155642Z
LAST-MODIFIED:20230328T155642Z
UID:106462-1681398000-1681405200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:Engineering the cancer: from biomaterials to on-chip solutions\nDavid Caballero; Research Institute on Biomaterials\, Biodegradables and Biomimetics\, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine\, University of Minho\, Portugal. \nCancer is a complex and multifaceted pathology\, which is influenced by numerous factors\, including the tumor microenvironment (TME). This environment is composed of various of components that interact in a tightly regulated manner\, affecting cancer cell behavior and response to treatment. Building realistic models of the TME is therefore essential for improving our knowledge of cancer pathophysiology and developing more effective therapies. In recent years\, there has been growing interest in using precisely-engineered biomaterials and microphysiological systems to create accurate 3D in vitro models of the TME. These models can provide a more physiologically-relevant habitat for studying fundamental aspects of cancer biology and for performing drug screening. Additionally\, when combined with organ-on-a-chip technology\, these models offer a high degree of biomimicry and control\, allowing for a precise recreation and better understanding of key biological functions of the native TME\, surpassing what traditional platforms can achieve. In this lecture\, I will present our latest works utilizing biomimetic materials and on-chip systems as powerful preclinical tools for engineering realistic in vitro models of the TME to study key aspects of tumorigenesis\, for drug screening/discovery purposes\, and for disease diagnosis applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-caballero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230421T093000
DTEND;TZID=Europe/Madrid:20230421T140000
DTSTAMP:20260403T211411
CREATED:20230309T170353Z
LAST-MODIFIED:20230309T170353Z
UID:105706-1682069400-1682085600@ibecbarcelona.eu
SUMMARY:Course · Inclusive Science; attention to diversity in science education projects
DESCRIPTION:This course aims to promote inclusive education in scientific education activities in non-formal settings\, guaranteeing access to scientific culture for all children and adolescents\, regardless of their learning needs. \nDuring the course\, general guidelines and guidelines will be presented to accompany students with visual disabilities\, as well as practical examples of STEAM activities. Accessibility and digital usability will also be addressed and tools will be offered to contribute to access to information for students with visual disabilities. \nThis course is organized by the Bioengineering Institute of Catalonia (IBEC) in collaboration with ONCE. \n  \nRegistration is required here.
URL:https://ibecbarcelona.eu/event/course-%c2%b7-inclusive-science-attention-to-diversity-in-science-education-projects/
LOCATION:Centro de Recursos Educativos ONCE Barcelona\, Gran Vía de les Corts Catalanes\, 394\, Barcelona.
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230426T110000
DTEND;TZID=Europe/Madrid:20230426T110000
DTSTAMP:20260403T211411
CREATED:20230412T131424Z
LAST-MODIFIED:20230412T131618Z
UID:107088-1682506800-1682506800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Ubaka Ogbogu
DESCRIPTION:Foregrounding justice\, equity and inclusion as determinants of access to precision medicine: an ethical case study of patient-derived tissue organoids.\nDr. Ubaka Ogbogu\, Professor and the Associate Dean Research in the Faculty of Law from the University of Alberta\, Canada.  \nUbaka Ogbogu is a Professor and the Associate Dean Research in the Faculty of Law. He is also the Chair of the University of Alberta Research Ethics Board 2 and the Katz Research Fellow in Health Law and Science Policy. Dr. Ogbogu is a recipient of the Confederation of Alberta Faculty Associations Distinguished Academic Early Career Award. He holds a doctorate in law from the University of Toronto\, a Master of Laws degree from the University of Alberta and undergraduate degrees in law from the University of Benin\, Nigeria and the Nigerian Law School. \nOgbogu’s scholarly work is focused broadly on the ethical\, legal and societal implications of novel and emerging biotechnologies and associated research. His publications have explored a diverse range of issues in this field\, including the ethical and legal issues associated with stem cell research\, gene and engineered cell therapies\, biobanks\, germline gene editing. In his talk\, Prof. Obgobu will reflect about these issues and also discuss how foregrounding justice\, equity and inclusion are elements that impact on access to precise medicine. \nHe has been invited to IBEC by Nuria Montserrat. \n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ubaka-ogbogu/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T100000
DTEND;TZID=Europe/Madrid:20230428T110000
DTSTAMP:20260403T211411
CREATED:20230420T113916Z
LAST-MODIFIED:20250306T162535Z
UID:107325-1682676000-1682679600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Ainoa Tejedera and Zarina Nauryzgaliyeva
DESCRIPTION:Mimicking Sarcolemmal Damage In vitro: A 3D Skeletal Muscle Model for Drug Testing in Duchenne Muscular Dystrophy\nAinoa Tejedera Villafranca\, Biosensors for bioengineering group \nDuchenne muscular dystrophy (DMD) is the most prevalent neuromuscular disease diagnosed in childhood. It is a progressive and wasting disease\, characterized by a degeneration of skeletal and cardiac muscles caused by the lack of dystrophin protein. The absence of this structural protein leads to the fragility of the sarcolemma\, and muscle fibers are damaged during their contraction. To date\, there is no cure available for patients\, even though there are several molecules in drug development. However\, due to the well-known limitations of preclinical research\, the success rate of drugs remains low. In this work\, intending to accelerate drug discovery for DMD\, we developed a patient-derived functional 3D model of DMD. By using a 3D-printed casting mold\, we encapsulated muscle progenitor cells in a fibrin-composite matrix. This platform incorporates two flexible T-shaped pillars that serve as anchoring points and provide continuous tension to the tissue\, thus allowing the orientation of the muscle fibers. The skeletal muscle tissues expressed mature myogenic markers and showed functional phenotypes as they responded to electrical pulse stimulation (EPS) by contracting. We observed that DMD muscle tissues\, after continuous contractile regimes\, reproduced the loss of myotube integrity that is observed in dystrophinopathies due to the sarcolemmal instability. DMD but not healthy tissues showed functional phenotypes caused by the induced sarcolemmal damage\, such as tetanic fatigue. Finally\, the applicability of this DMD model in evaluating therapeutic compounds was explored. Specifically\, we investigate the effect of utrophin up-regulators on functional outcomes of the model\, thus identifying potential candidates for the treatment of DMD. Taking all these considerations together\, our results show that bioengineered 3D skeletal muscle technology has great potential to be especially valuable in the context of current and future discovery and development of drugs to treat DMD and other neuromuscular disorders. \n\nDissecting early nephron patterning and segmentation in kidney organoids derived from hPSCs\nZarina Nauryzgaliyeva \, Pluripotency for organ regeneration Group \nThe formation and maturation of organs during development is a complex\, yet beautifully orchestrated process. Embryonic cells have a unique capacity to self-organize within the forming tissue\, where morphogenetic movements have been shown to facilitate tissue organization and subsequent organ formation. In kidney organogenesis\, the mature organ arises from crucial reciprocal interactions between the ureteric bud (UB) and metanephric mesenchyme (MM)\, which give rise to the collecting duct and nephron\, respectively. The development of mature nephrons during kidney organogenesis is a dynamic process so far studied taking advantage of in vivo models. Accumalative findings in mice have shown that the MM undergoes mesenchymal to epithelial transition (MET)\, giving rise to epithelial renal vesicles (RVs) that further undergo structural changes and shift towards comma shaped and s-shaped bodies (CSBs/SSBs)\, which eventually develop into nephron like structures. Those studies have helped identify Wnt/b-catenin and Notch signalling pathways as key players in nephron patterning and segmentation (proximal\, medial\, distal segments).\nAt the same time\, tissue morphogenesis is largely a biomechanical process\, resulting from constant movements of cells\, changes in forms of developing segments and forces generated therein. The biomechanical dynamics occurring during RV emergence and further nephron patterning are yet to be explored in the human context in real time. If these biomechanical processes are interconnected with mechanical signals remains an open question in the field. The answer to these questions may have an important impact for understanding nephron formation\, and conversely\, disease-related phenotypes due to mutations in genes orchestrating RV patterning and segmentation as occurs in congenital defects of the kidney and the urinary tract (CAKUT disease).\nHere\, we aim to use human pluripotent stem cell (hPSCs) derived kidney organoids to gain fundamental understanding of early nephron patterning and segmentation by mapping force transmission between cells and their extracellular matrix (ECM) and evaluating their co-evolution during renal fate specification and differentiation.\nhPSCs are guided towards the renal fate on compliant PDMS hydrogels with controlled rigidities (mimicking embryonic microenvironment) in a 2D culture system. PDMS hydrogels between 3 kPa (soft) and 18 kPa (rigid) are generated by adapting the compositional ratio of PDMS components and are further functionalized and decorated with fibronectin. Using this system\, we have started to spatiotemporally characterise early steps of nephrogenesis by immunofluorescence and confocal analysis\, time-lapse imaging\, and traction force microscopy (TFM). These analyses are nowadays conducted during RV emergence prior proximal-distal RV polarization and formation of the nephron-like segments.\nThe current techniques will permit quantitative and qualitative observations of multicellular behaviours at key stages of 2D renal differentiation. Furthermore\, this system will allow us to spatiotemporally map cell-cell and cell-ECM forces and evaluate their evolution throughout renal fate specification with the final aim to decouple mechano-related processes sustaining nephron formation from classical biochemical signalling. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am. \n  \nWith the support of Joan Oró grant to hire research staff in training (FI 2025)\, 2023 FI-2 00386\, funded by Generalitat de Catalunya and by the European Social Fund Plus. \n \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-ainoa-tejedera-and-zarina-nauryzgaliyeva/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T120000
DTEND;TZID=Europe/Madrid:20230428T133000
DTSTAMP:20260403T211411
CREATED:20230309T155632Z
LAST-MODIFIED:20230426T104601Z
UID:105698-1682683200-1682688600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Charles Baroud
DESCRIPTION:Modeling immune-cancer interactions using a microfluidic 3D culture approach\nCharles Baroud\, Professor at Ecole Polytechnique\, France\nLab head at Institut Pasteur\, Paris\, France \nCancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach\, which has shown some remarkable successes\, leverages the patient’s own immune cells to locate and attack the tumor cells. However the method suffers from large heterogeneities in outcomes between different patients\, in part due to the the number\, phenotype\, and distribution of cytotoxic T cells (CTLs) around the tumor cells. For this reason decoding the collective behavior of CTLs\, as they recognize and attack cancer cells\, is a major challenge that requires advanced in vitro models. This seminar will present a microfluidic platform that enables quantitative measurements of the spatiotemporal dynamics of individual CTLs as they migrate in three-dimensional (3D) environments and attack cancer spheroids. The method provides access to the trajectories of thousands of cells around hundreds of spheroids\, which in turn enables probabilistic modeling of the trajectories. Analysis of the migration and killing events allows us to dissect the different phases of interactions and to identify limiting steps for different conditions. The talk will present the microfluidics and then shift focus to different biological models\, with implications for both fundamental biology and for personalized medicine. \n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-charles-baroud/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230505T090000
DTEND;TZID=Europe/Madrid:20230505T183000
DTSTAMP:20260403T211411
CREATED:20230324T111823Z
LAST-MODIFIED:20230324T111823Z
UID:106492-1683277200-1683311400@ibecbarcelona.eu
SUMMARY:Before mechanobiology had a name
DESCRIPTION:A celebration of three decades of cell biophysics research in Barcelona\n\n\n\n\n\nThe Barcelona area is currently recognized as an important hub for the scientific field of mechanobiology\, and of cell biophysics in general. This achievement is due to the work over decades of local scientists. Among them\, Prof. Daniel Navajas stands out as a pioneer in the field\, before it was even called mechanobiology. His work led to important scientific achievements in cell mechanics. Perhaps even more importantly\, his dedicated mentorship produced a new generation of scientists who have established their own labs and are currently expanding mechanobiology in new directions. \nOn the occasion of Prof. Navajas’s retirement\, we take the opportunity to celebrate Mechanobiology and cell biophysics\, with a symposium combining talks from former trainees and invited speakers. \nThe symposium will honor an exciting trajectory along three decades\, but will be focused on current\, ongoing research. As such\, it will be of interest to anyone interested in mechanobiology\, with or without a relationship to the work of Prof. Navajas.  \nRegistration here.
URL:https://ibecbarcelona.eu/event/before-mechanobiology-had-a-name/
LOCATION:Paranimf Facultat de Medicina i Ciències de la Salut C. Casanovas\, 143 Barcelona
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230506T103000
DTEND;TZID=Europe/Madrid:20230506T123000
DTSTAMP:20260403T211411
CREATED:20230427T140736Z
LAST-MODIFIED:20230427T140736Z
UID:107578-1683369000-1683376200@ibecbarcelona.eu
SUMMARY:Workshop on scientific illustration
DESCRIPTION:On May 6th\, Roser Cussó\, the artist in residence at IBEC\, will be offering a scientific illustration workshop designed for participants of all ages (starting from 7 years old). \nThis is an open session available to everyone\, where you will have the chance to explore the creative process that Roser followed during her project “Laboratori de Paisatges Humans”. \nDuring this workshop\, you will learn how to take an artistic approach to scientific concepts\, as well as discover various techniques and materials that can help you create your own scientific illustrations. \nAs there are limited spots available\, make sure to sign up for this unique session on Saturday\, May 6th from 10:30 am to 12:30 pm at the Baobab meeting room (Torre I\, planta 11\, PCB). \nFeel free to come with your family and friends! \nREGISTER \nLABORATORI D’IL·LUSTRACIÓ CIENTÍFICA  \nEl pròxim 6 de maig\, Roser Cussó\, l’artista en residència a l’IBEC\, ens oferirà un taller d’il·lustració científica adaptat per a totes les edats (a partir de 7 anys). \nEs tracta d’una sessió oberta a tothom a on tindràs l’oportunitat d’aprendre el procés creatiu que va seguir Roser durant el seu projecte “Laboratori de Paisatges Humans”. \nAquest taller et permetrà posar una mirada artística a conceptes científics\, aprendre diferents tècniques de representació i treballar amb diversos materials que et serviran per crear la teva pròpia obra. \nAmb places limitades\, no et perdis l’oportunitat d’inscriure’t en aquesta sessió única el dissabte 6 de maig d’10:30 a 12:30 h a la sala Baobab (Torre I\, planta 11\, PCB)  \nVine amb familiars i amics! T’esperem!
URL:https://ibecbarcelona.eu/event/workshop-on-scientific-illustration/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230518T103000
DTEND;TZID=Europe/Madrid:20230518T130000
DTSTAMP:20260403T211411
CREATED:20230427T083055Z
LAST-MODIFIED:20230427T083055Z
UID:107566-1684405800-1684414800@ibecbarcelona.eu
SUMMARY:Research 4 Talent
DESCRIPTION:This event is open to all undergraduate and master students interested in a research career. \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2022 IBEC signed more than 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s ninth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research-4-talent/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230526T110000
DTEND;TZID=Europe/Madrid:20230526T130000
DTSTAMP:20260403T211411
CREATED:20230315T112426Z
LAST-MODIFIED:20230315T113622Z
UID:105907-1685098800-1685106000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Raphael Voituriez
DESCRIPTION:Cellular footprints : examples of emergent memory effects in cell migration.\nRaphael Voituriez\, Laboratoire Jean Perrin / Laboratoire de Physique Théorique de la Matière Condensée CNRS / Sorbonne Université\n \nLiving cells actively migrate in their environment to perform key biological functions—from unicellular organisms looking for food to single cells such as fibroblasts\, leukocytes or cancer cells that can shape\, patrol or invade tissues. Cell migration results from complex intracellular processes that enable cell self-propulsion\, and has been shown to also integrate various chemical or physical extracellular signals. While it is established that cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix\, the impact of such self-induced environmental perturbations on cell trajectories at various scales remains broadly unexplored. I will discuss examples where such interactions with the environment can have deep consequences on the large scale cell dynamics\, and show that they can effectively endow cells with a memory of their past trajectory.
URL:https://ibecbarcelona.eu/event/ibec-seminar-raphael-voituriez/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230529T123000
DTEND;TZID=Europe/Madrid:20230529T140000
DTSTAMP:20260403T211411
CREATED:20230515T084601Z
LAST-MODIFIED:20230518T115408Z
UID:107973-1685363400-1685368800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anthony J. Ryan OBE
DESCRIPTION:Making Science Work for Refugees and Refugees Work for Science\nProf Anthony J. Ryan\, OBE\, University of Sheffield\, UK \nAt Zaatari refugee camp\, 80\,000 people face daily struggles that many of us cannot imagine are squeezed into six square kilometres. With highly qualified jobs at home\, they are forcibly unemployed at the camp but embody values that are often forgotten by those of us in more privileged parts of the world: an adaptable approach to solving problems\, an aversion to waste\, a sense of community. Our research on hydroponics is focussed on the production of high-value crops close to market (urban farming) with a low carbon and water footprint using polyurethane foam as synthetic soil. I will show how a design of experiments approach can predict the productivity of crops from the reagents used in polyurethane synthesis through the properties of the foam.\nWe connected our work on synthetic soils with a waste disposal problem posed by UNHCR – the UN’s refugee agency. Where they saw dirty unused mattresses\, we saw an alternative growth substrate. In doing so we developed small-scale hydroponics at the household and community scale. We responded to the frequent cry of the Syrian refugees – that they miss the colour green – not only did we find a technical fix\, but also an impact on well-being. This benefits our work in Sheffield\, we now have an urban farm built using the low-cost technology developed in Zaatari with farmers from Syria. \n\nProfessor Tony Ryan OBE is The Professor of Physical Chemistry at the University of Sheffield and the founding Director of the Grantham Centre for Sustainable Futures.\nTony’s research interests include sustainable synthesis\, structure\, processing\, and applications of polymers using advanced analytical and measurement techniques. Recent research projects included renewable sources for polyurethane synthesis\, organic photovoltaics\, maximising the properties of polymers and biopolymers through flow-induced crystallisation\, formulation of home and personal care products and polymer foams for high-intensity urban agriculture. He has co-authored more than 300 papers and patents and 2 books\, “Polymer Processing and Structure Development” and “The Solar Revolution: One Planet\, 10 Billion People\, One Solution.”\nMore recently\, Tony has been focussing on the global challenge of the food\, water\, and energy nexus; feeding a growing world population. Tony is very active in translational research\, disseminating evidence-based science to both experts and non-experts and has been a regular contributor to TV\, Radio\, National Press and learned societies from The Royal Society of Chemistry to Chatham House\, The Royal Institute of International Affairs. He presented evidence at the UNFCCC COP21 in Paris in 2015 and returned to COP22 in Marrakech in 2016. Tony delivered the televised Royal Institution Christmas Lectures in 2002 and was awarded an OBE in 2006 for ‘Services to Science’.\nTony holds a BSc and PhD from the University of Manchester and a DSc from UMIST. He held a NATO Research Fellowship at the University of Minnesota\, was a Lecturer\, Senior Lecturer and Reader in Materials Science at The University of Manchester and was seconded to the Synchrotron Radiation Source at Daresbury. In 1997 he moved to Sheffield and served as Head of Chemistry before becoming the Pro Vice Chancellor for the Faculty of Science in 2008\, a role which he fulfilled until 2016.
URL:https://ibecbarcelona.eu/event/ibec-seminar-anthony-j-ryan/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230530T100000
DTEND;TZID=Europe/Madrid:20230530T180000
DTSTAMP:20260403T211411
CREATED:20230503T091502Z
LAST-MODIFIED:20230503T091502Z
UID:107643-1685440800-1685469600@ibecbarcelona.eu
SUMMARY:Innovación multidisciplinar en medicina personalizada (Spanish)
DESCRIPTION:30 DE MAYO DE 2023 · INSTITUTO DE SALUD CARLOS III \n\n\n\n\nLa jornada «Innovación multidisciplinar en medicina personalizada» es un evento organizado en el marco del Plan Complementario de Biotecnología aplicada a la Salud. Durante el evento se presentarán las principales líneas de trabajo del Plan\, que abarcan temas que van desde el uso y gestión de bases de datos en medicina de precisión hasta el desarrollo de nanofármacos\, así como técnicas y procesos para terapias avanzadas y dirigidas.   \nEl objetivo de la jornada es fortalecer y estimular colaboraciones entre los diferentes actores del ecosistema de investigación traslacional en salud.  \nLa jornada también servirá para crear sinergias con los diferentes programas y plataformas financiadas por el ISCIIII. 
URL:https://ibecbarcelona.eu/event/innovacion-multidisciplinar-en-medicina-personalizada-spanish/
LOCATION:Instituto de Salud Carlos III Salón de Actos Ernest Lluch\, pabellón 13 Campus de Chamartin Calle Monforte de Lemos\, 5 Madrid
CATEGORIES:External symposium / conference / congress,IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230606T093000
DTEND;TZID=Europe/Madrid:20230606T110000
DTSTAMP:20260403T211411
CREATED:20230503T152810Z
LAST-MODIFIED:20230503T152810Z
UID:107647-1686043800-1686049200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Danny Hatters
DESCRIPTION:Protein interactions gone awry in neurodegenerative disease\nDanny Hatters\, Department of Biochemistry and Pharmacology | Faculty of Medicine\, Dentistry and Health Sciences\nThe University of Melbourne\,  Australia\n \nThe Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine principles governing how proteins inappropriately aggregate and new approaches with chemical reagents to monitor cysteine reactivity to probe changes in proteome foldedness and conformation. I will discuss recent findings from our laboratory that provide insight to the consequences of protein aggregation by globular proteins\, and how we can model the types of protein-protein interactions that are involved. I will also discuss how we can monitor changes in protein structure and function in response to stresses and stimuli\, and under conditions of disease in Huntington Disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-danny-hatters/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230606T150000
DTEND;TZID=Europe/Madrid:20230606T180000
DTSTAMP:20260403T211411
CREATED:20230523T080627Z
LAST-MODIFIED:20230523T080627Z
UID:108201-1686063600-1686074400@ibecbarcelona.eu
SUMMARY:Greening the lab: celebrating ibec's sustainable practices
DESCRIPTION:On 6th of June we will celebrate that we are the first research center in Spain to certify its laboratories as sustainable by My Green Labs. \nSince the publication of the IBEC Strategy to promote sustainability in research in 2021\, IBEC has been working to make the work in the labs and in the institute more sustainable. \nAll this work has been recently recognized by becoming the first research center in Spain to certify its laboratories as sustainable by My Green Labs. \nThe next 6th of June at 3pm\, we will celebrate this success and share our experience and best practices.  \nCome and join us at the PCB!
URL:https://ibecbarcelona.eu/event/greening-the-lab-celebrating-ibecs-sustainable-practices/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230607T090000
DTEND;TZID=Europe/Madrid:20230609T150000
DTSTAMP:20260403T211411
CREATED:20230427T075924Z
LAST-MODIFIED:20230427T075924Z
UID:107560-1686128400-1686322800@ibecbarcelona.eu
SUMMARY:Advanced Functional Polymers for Medicine 2023​ conference
DESCRIPTION:The purpose of the AFPM conference series is to strengthen the interactions within the community of chemists\, material engineers\, physicists\, biologists and clinicians in the development of Advanced Functional Polymers for Medicine. \nThe current status\, challenges and requirements for future developments of polymers for medicine are presented by leading experts. The conference provides an outstanding opportunity to help young scientists in their career development and offers them an interdisciplinary discussion forum within an exclusive circle. \nInformation\, programme\, and registration fee here.
URL:https://ibecbarcelona.eu/event/advanced-functional-polymers-for-medicine-2023-conference/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230609T100000
DTEND;TZID=Europe/Madrid:20230609T110000
DTSTAMP:20260403T211411
CREATED:20230529T161933Z
LAST-MODIFIED:20230529T161933Z
UID:108343-1686304800-1686308400@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills: From Lab to Clinic
DESCRIPTION:From Lab to Clinic: An Overview of IBEC’s Clinical Mentoring Programme\nDo you know what IBEC’s Clinical Mentoring Programme is about? Have you considered participating in it?\nIn this Complementary Skills session\, Anna Gassol and Georgina Sorrosal from Col·legi official de Metges (COMB) together with Cristina Arimany from the Strategic Initiatives department at IBEC will explain the basis of the program. Meritxell Serra Casablancas (Smart Nano-Bio-Devices Group) and Luisa Camerin (Nanoprobes and Nanoswitches Group) will share their experience as the first mentees participating in the programme.\nThis will also be a great opportunity to learn how the programme can help in the clinical translation of the work done at IBEC and answer any questions you may have about it.
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-from-lab-to-clinic/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230612T120000
DTEND;TZID=Europe/Madrid:20230612T130000
DTSTAMP:20260403T211411
CREATED:20230607T125347Z
LAST-MODIFIED:20230607T125558Z
UID:108508-1686571200-1686574800@ibecbarcelona.eu
SUMMARY:BIST Open Seminar: Roberta Croce
DESCRIPTION:Natural Strategies for Solar Light Harvesting\nProfessor of Biophysics\, Photosynthesis and Energy at Department of Physics of the Vrije Universiteit in Amsterdam. \nIn this presentation I will introduce the fundamental processes of light harvesting in photosynthetic organisms and discuss their remarkable abilities to adapt and acclimate to diverse light conditions. Photosynthetic organisms have evolved sophisticated strategies to capture and utilize solar energy efficiently\, allowing them to thrive in various environments. This presentation will delve into the mechanisms by which these organisms optimize their light-harvesting capabilities\, including pigment choice\, photoprotection\, and dynamic responses to changes in light quality and quantity.\nThe presentation will discuss key aspects of light harvesting\, such as the spectral tuning of pigments to match available light wavelengths and the regulation of energy flow to prevent damage caused by excess light. Additionally\, the remarkable acclimation abilities of photosynthetic organisms to gradual changes in light intensity will be explored\, highlighting their capacity to fine-tune their photosynthetic machinery for optimal performance under varying light conditions.\nBy examining the natural strategies employed by photosynthetic organisms\, this presentation aims to provide insights into the principles of solar light harvesting. Understanding these natural strategies offers valuable lessons for optimizing light-harvesting systems and harnessing solar energy in a sustainable and efficient manner. \n\nRoberta Croce studied chemistry at the University of Padova and completed her Ph.D. in Plant Biology/Biophysics at the University of Milano in 1998. After two postdoc periods in Germany (MPI Mulheim a.d. Rurh) and Italy (University of Verona)\, she got a permanent position at the Institute of Biophysics of the CNR. In 2006 she moved to the University of Groningen where she became associate professor in 2008. Since 2011 she is Professor of Biophysics\, Photosynthesis and Energy at Department of Physics of the Vrije Universiteit in Amsterdam. Her research focuses on the molecular mechanisms of photosynthesis\, using an integrated approach including molecular biology\, biochemistry and ultrafast spectroscopy. She published more than 180 scientific articles on the topic of photosynthesis. She is an elected member of the Royal Netherlands Academy of Arts and Sciences (KNAW) and the Royal Holland Society of Science and Humanity (KHMW). She is also a member of the Board of Reviewing Editors of Science and the Plant Cell\, and the recipient of several personal research grants. In 2022 she was elected president of the International Society of Photosynthesis.
URL:https://ibecbarcelona.eu/event/bist-open-seminar-roberta-croce/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230619T123000
DTEND;TZID=Europe/Madrid:20230619T133000
DTSTAMP:20260403T211411
CREATED:20230502T111657Z
LAST-MODIFIED:20230607T134735Z
UID:107616-1687177800-1687181400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Amnon Buxboim
DESCRIPTION:How does ageing-related stiffening of brain tissue microenvironments affect the regenerative capacity of cns progenitor cells\nProfessor of biology and bioengineering\, the Hebrew University of Jerusalem\, Israel. \nAgeing-related stiffening of neuronal microenvironments in the brain generates potent signals that attenuate the regenerative capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate. We find that ageing drives substantial remolding of the nuclear lamina in OPCs\, in which A-type lamin levels increase and B-type lamin expression decreases. Owing to the ubiquitous role of lamins in anchoring mostly heterochromatic sections at the nuclear envelope known as lamina associated domains (LAD’s)\, we hypothesized that ageing effects are mediated via altered genomic organization and regulation. In this study\, we isolate OPCs from neonate and aged rats and study the effects of ageing-related tissue stiffening by designing and optimizing hydrogel-based matrices that mimic the extracellular elasticity and adhesion signals of neonate and aged microenvironments. Indeed\, the differences in cellular morphologies and lamina compositions between neonate and aged cells are recapitulated by matrix elasticity. To characterize differences in the structural organization of the nuclear lamina\, we combine high-resolution optical and electron microscopies and perform micropipette aspiration based rheology to define the viscoelastic properties of OPC nuclei within intact cells. LAD mapping is performed using optimized CUT&RUN assays that target endogenous lamin-B1\, thus avoiding the effects of ectopic expression of nuclear envelope proteins\, which is a prerequisite by standard methodologies. Downstream effects on transcriptional regulation are studied via single-cell RNA sequencing (scRNA-seq)\, thus providing insight into cell-to-cell variations. In summary\, our work-in-progress highlights the mechanobiological component of ageing on progenitor cells of the CNS that can stimulate potential therapeutic strategies. \n\nDr. Amnon Buxboim is a professor of biology and bioengineering\, the Hebrew University of Jerusalem\, Israel. Trained as a biophysicist\, he opened the Buxboim Lab for Mechanobiology in 2013. Dr. Buxboim research aims at understanding how physical and mechanical inputs combine with parallel signaling pathways to direct cell-fate decision-making processes. The Buxboim Lab studies oocyte maturation\, preimplantation embryo development\, stromal bone marrow immunomodulation\, and CNS stem/progenitor cell ageing. Dr. Buxboim also studies mechanisms of nuclear mechanotransduction\, as mediated via nuclear lamins and associated nuclear envelope proteins. The Buxboim Lab combines established assays\, advanced computational tools\, newly designed device-based technologies\, and integrates single-cell level genomics with micro-rheological measurements. Based on his research findings\, Dr. Buxboim develops assisted reproductive technologies to advance and improve medical care.
URL:https://ibecbarcelona.eu/event/ibec-seminar-amnon-buxboim/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230620T113000
DTEND;TZID=Europe/Madrid:20230620T133000
DTSTAMP:20260403T211411
CREATED:20230502T111443Z
LAST-MODIFIED:20230607T134316Z
UID:107614-1687260600-1687267800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Magali Suzanne
DESCRIPTION:Mechanical impact of cell delamination on tissue dynamics\, in developmental and tumoral contexts\nCentre de Biologie Intégrative\, CNRS/UMR 5088\, Université Toulouse III\, Toulouse\, France \nHow mechanical forces drive morphogenesis is a fundamental question in the field of biomechanics. Combining imaging\, genetics\, biophysical and modeling approaches\, we found that apoptotic cells\, far from being eliminated passively\, exert a force before dying and thus actively participate in tissue remodeling. This transient force\, generated in the depth of the epithelium\, constitute a mechanical signal involved in tissue folding. Comparing apoptotic cell dynamics to cells undergoing EMT\, we found that a very similar apico-basal force is generated at the onset of EMT.\nWe further deciphered how these forces are transmitted at the tissue scale through the characterization of a specific mechanical state favoring directional force transmission and developed a new method that offers the opportunity to extract automatically\, in strongly deformed epithelia\, a precise characterization of the spatial organization of a given cytoskeletal network combined to morphological quantifications in highly remodeled 3D epithelial tissues.\nIn parallel\, we turned to cancer mechanics\, focusing particularly in tumor progression. Cancer is a largely widespread pathology that corresponds to an overproliferation of cells that could finally invade others tissues. Tumors develop through three increasingly aggressive steps: (1) hyperplasia\, which corresponds to cells overproliferation; (2) dysplasia\, during which cells can acquire a more mesenchymal phenotype\, and finally (3) metastasis. Tumor development can be influenced by mutations but also by external factors\, such as extracellular matrix rigidity. However\, a comprehensive understanding of the intrinsic factors driving tumor evolution is still lacking. Our recent unpublished work identifies unexpected factors that could influence tumor development\, and more specifically the hyperplasia/dysplasia transition\, a critical step in tumor aggressiveness. This work highlights puzzling differences between developmental and tumoral mechanics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-magali-suzanne/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230620T150000
DTEND;TZID=Europe/Madrid:20230620T170000
DTSTAMP:20260403T211411
CREATED:20230619T071822Z
LAST-MODIFIED:20230619T071946Z
UID:108633-1687273200-1687280400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Nimesh Ramesh Chahare
DESCRIPTION:Mechanics of Epithelial tissue subjected to controlled pressure\n\n\n\n\nAuthor: Nimesh Ramesh Chahare\, Integrative Cell and Tissue Dynamics group\n\n\n\nBiography: \nNimesh Ramesh Chahare earned his bachelor’s degree in Mechanical Engineering from the National Institute of Technology\, Nagpur in 2014. He further pursued a master’s degree at the Indian Institute of Science\, Bengaluru\, completing it in 2016. In 2017\, he began his doctoral work in Barcelona\, under the guidance of Prof. Marino Arroyo at Universitat Politècnica de Catalunya\, and Prof. Xavier Trepat at the Institute of Bioengineering of Catalonia. Currently\, he is a PhD candidate in applied mathematics\, specializing in the study of the mechanics of epithelial tissue under controlled pressure. \nAbstract: \nEpithelial sheets form specialized 3D structures suited to their physiological roles\, such as branched alveoli in the lungs\, tubes in the kidney\, and villi in the intestine. To generate and maintain these structures\, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses\, viscoelasticity\, and luminal pressure remains poorly understood. To address this question\, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup\, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure\, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach\, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However\, under sudden pressure reductions\, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events. \n  \n\n\nReading date: 20/06/2023\nReading time: 15:00 \nReading place: Facultat de Matemàtiques i Estadística-Sala d’Actes FME\, Edifici U\, Campus Sud\nThesis director: ARROYO BALAGUER\, MARINO and TREPAT GUIXER\, XAVIER\nCommittee:\nPRESIDENT: TRIVEDI\, VIKAS\nSECRETARI: MUÑOZ ROMERO\, JOSE JAVIER\nVOCAL: SUZANNE\, MAGALI \n\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-nimesh-ramesh-chahare/
LOCATION:acultat de Matemàtiques i Estadística-Sala d’Actes FME\, Edifici U\, Campus Sud
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230628T120000
DTEND;TZID=Europe/Madrid:20230628T130000
DTSTAMP:20260403T211411
CREATED:20230626T100738Z
LAST-MODIFIED:20230626T103836Z
UID:109214-1687953600-1687957200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Benjami Oller-Salvia
DESCRIPTION:Development of chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases\nDr. Benjami Oller-Salvia\, IQS \nIn our group we develop chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases. In the first part of the talk\, I will report our efforts toward developing strategies to construct conditionally-active biotherapeutics that target antigens considered undruggable. In the second part of the talk\, I will present our work on peptides for drug delivery across the blood brain barrier. There\, I will highlight the recent development of a new family of bicyclic brain shuttles and provide a hint toward new ways of exploring brain transport. .
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-benjami-oller-salvia/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230630T100000
DTEND;TZID=Europe/Madrid:20230630T110000
DTSTAMP:20260403T211411
CREATED:20230621T150854Z
LAST-MODIFIED:20230623T093647Z
UID:108921-1688119200-1688122800@ibecbarcelona.eu
SUMMARY:PhD Discussion: Isabela Fortunato y Marina Martinez
DESCRIPTION:Cell migration up and down fibronectin gradients\nIsabela Fortunato\, Integrative cell and tissue dynamics group \nThe ability of cells to perform directed migration is essential for biological processes\, such as tissue morphogenesis\, immune function\, and cancer invasion. Directed cell migration is often triggered by spatial gradients in the cellular environment (e.g.\, chemical gradients\, called chemotaxis\, substrate stiffness gradients\, called durotaxis\, or substrate-bound ligand gradients\, called haptotaxis). Haptotaxis has been described in vivo as an important phenomenon during physiological and pathological conditions. However\, the molecular and mechanical processes that drive this form of directed cell migration remain elusive. Moreover\, generating accurate and reliable gradients of immobilized protein in vitro has been challenging and makes it harder to study haptotaxis. Here\, we explore how cells sense and respond to gradients of immobilized proteins. We used a photopatterning technique to create well-controlled fibronectin gradients and we studied the migration of single mammary epithelial cells (MCF-10A). This approach allowed us to map cell migration velocity\, traction forces\, and actin cytoskeleton dynamics as a function of fibronectin density. We observed that cells respond to fibronectin gradients by an initial polarization towards higher protein density in the first hours of migration. Surprisingly\, after the initial polarization\, cells maintained their directionality even if they were submitted to a negative protein gradient. This suggests that cells adapt their polarity features to maintain the preexisting structures and organelles geometry towards low fibronectin regions until a limitation on creating new adhesions. In this work we find that one key adaptation mechanism is driven by the actin flows\, specifically the increase in actin polymerization velocity at the leading edge. Besides haptotaxis\, we foresee that these results will shed light on other forms of directed cell migration in which cells integrate several internal and external cues to orient themselves in physiological and pathological processes. \n\nLiving myocardial slices as a representative in vitro platform for translational cardiovascular disease\nMarina Martínez\, Biomaterials for Regenerative Therapies group \nCardiovascular diseases are the leading cause of global mortality\, accounting for nearly 45% of all deaths in Europe. Myocardial infarction (MI) is a prevalent condition\, where a region of the cardiac muscle undergoes ischemia and up to one billion cardiomyocytes die in just a few hours. The heart has a limited regenerative ability; consequently\, cardiomyocytes lost due to MI cannot be replaced. In this scenario\, researchers have investigated and developed alternative therapies to promote cardiac repair and regeneration. \nLactate\, an important metabolite during cardiogenesis and cardiac development\, has been recently described as a potential modulator of the phenotype of cardiac cells in vitro. These findings support a novel use of lactate for endogenous heart regeneration strategies. Nevertheless\, effectiveness of ongoing therapeutic approaches is dependent on the level of maturation of cardiac tissue. Hitherto\, the regenerative capabilities of lactate in mature cardiac tissue have not been described. In this work\, we used living myocardial slices (LMS) as a model of mature cardiac tissue. LMS are 300 μm-thick slices of living myocardium with conserved physiological structure and function. Human and rat adult LMS were treated with lactate to evaluate early cellular\, molecular\, and functionality changes related to myocardial reprogramming\, cardiac structural rearrangements\, and fibrosis. Moreover\, the effect of lactate was characterized in both healthy and injured adult myocardium. \nFunctionally\, (8 mM) lactate-treated healthy and pathological human LMS displayed an increase in contractility. Expression of fibrotic\, pluripotency transcription factors\, and cardiomyocyte markers were detected. Exposure of healthy rat LMS to higher concentrations of lactate (20 mM) did not affect LMS viability nor altered LMS contractile force\, while promoted LMS stiffening. In cryoinjured rat LMS\, lactate drastically increased contractility and altered tissue remodeling in the region bordering the injury. \nLMS provide a representative in vitro platform for translational cardiovascular research. By using LMS\, characterization of the effect of lactate in mature cardiac tissue has been achieved. Exogenous lactate enhanced cardiac function in both human and injured rat LMS. Upregulation of transcription factors and cardiomyocyte markers may suggest an effect on partial cardiomyocyte reprogramming that would counteract the effects of tissue stiffening. Altogether\, this study further supports the prospective use of lactate as a bioactive signal in new endogenous cardiac regeneration strategies. \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion-isabela-fortunato/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
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