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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161027T103000
DTEND;TZID=Europe/Madrid:20161028T153000
DTSTAMP:20260406T032553
CREATED:20161011T152811Z
LAST-MODIFIED:20161011T152811Z
UID:95923-1477564200-1477668600@ibecbarcelona.eu
SUMMARY:FRAILTY - A societal challenge in need of integrated solutions
DESCRIPTION:FRAILTY – A societal challenge in need of integrated solutions\nOctober 27th-28th\nWe are very pleased to welcome you to this Frailty Workshop\, mainly intended to deepen in this concept\, a state of high vulnerability to low-power stressors\, which place older people at high risk of becoming disabled. Frailty has risen in the last two decades as one of the most innovative concepts in the field of Health and Social Sciences for older adults. The old framework approaches disability by treating diseases. Overcoming it by acting on functional issues arises from the main idea of detecting and intervening in the earliest phases of the functional deterioration leading to disability and dependence. Frailty also demands the incorporation of an appropriate technology to provide clues to its detection and diagnosis and to an integrated\, continued and coordinated management. Frailty concept offers the best window of opportunity to significantly reduce the burden of disability in our aged societies. \nGoals: \n– Updates from key opinion leaders in the field\n– To introduce EIT and EIT Health to a broad audience in Spain\n– To present the FACET project: service and product to promote frailty care and prevention\n– Business opportunities related to frailty\n– To reach stakeholders and take action regarding frailty. \nMore information \n[br] \nUseful dates:\nWorkshop dates: October 27th-28th\, 2016
URL:https://ibecbarcelona.eu/event/frailty-a-societal-challenge-in-need-of-integrated-solutions-2/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161027T103000
DTEND;TZID=Europe/Madrid:20161028T153000
DTSTAMP:20260406T032553
CREATED:20161011T152811Z
LAST-MODIFIED:20161011T152811Z
UID:95932-1477564200-1477668600@ibecbarcelona.eu
SUMMARY:FRAILTY - A societal challenge in need of integrated solutions
DESCRIPTION:FRAILTY – A societal challenge in need of integrated solutions\nOctober 27th-28th\nWe are very pleased to welcome you to this Frailty Workshop\, mainly intended to deepen in this concept\, a state of high vulnerability to low-power stressors\, which place older people at high risk of becoming disabled. Frailty has risen in the last two decades as one of the most innovative concepts in the field of Health and Social Sciences for older adults. The old framework approaches disability by treating diseases. Overcoming it by acting on functional issues arises from the main idea of detecting and intervening in the earliest phases of the functional deterioration leading to disability and dependence. Frailty also demands the incorporation of an appropriate technology to provide clues to its detection and diagnosis and to an integrated\, continued and coordinated management. Frailty concept offers the best window of opportunity to significantly reduce the burden of disability in our aged societies. Goals: – Updates from key opinion leaders in the field – To introduce EIT and EIT Health to a broad audience in Spain – To present the FACET project: service and product to promote frailty care and prevention – Business opportunities related to frailty – To reach stakeholders and take action regarding frailty. More information [br] Useful dates: Workshop dates: October 27th-28th\, 2016
URL:https://ibecbarcelona.eu/event/frailty-a-societal-challenge-in-need-of-integrated-solutions-2-2/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161027T103000
DTEND;TZID=Europe/Madrid:20161028T153000
DTSTAMP:20260406T032553
CREATED:20161011T152811Z
LAST-MODIFIED:20161011T152811Z
UID:95933-1477564200-1477668600@ibecbarcelona.eu
SUMMARY:FRAILTY - A societal challenge in need of integrated solutions
DESCRIPTION:FRAILTY – A societal challenge in need of integrated solutions\nOctober 27th-28th\nWe are very pleased to welcome you to this Frailty Workshop\, mainly intended to deepen in this concept\, a state of high vulnerability to low-power stressors\, which place older people at high risk of becoming disabled. Frailty has risen in the last two decades as one of the most innovative concepts in the field of Health and Social Sciences for older adults. The old framework approaches disability by treating diseases. Overcoming it by acting on functional issues arises from the main idea of detecting and intervening in the earliest phases of the functional deterioration leading to disability and dependence. Frailty also demands the incorporation of an appropriate technology to provide clues to its detection and diagnosis and to an integrated\, continued and coordinated management. Frailty concept offers the best window of opportunity to significantly reduce the burden of disability in our aged societies. Goals: – Updates from key opinion leaders in the field – To introduce EIT and EIT Health to a broad audience in Spain – To present the FACET project: service and product to promote frailty care and prevention – Business opportunities related to frailty – To reach stakeholders and take action regarding frailty. More information [br] Useful dates: Workshop dates: October 27th-28th\, 2016
URL:https://ibecbarcelona.eu/event/frailty-a-societal-challenge-in-need-of-integrated-solutions-3/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161027T000000
DTEND;TZID=Europe/Madrid:20161027T130000
DTSTAMP:20260406T032553
CREATED:20161020T122619Z
LAST-MODIFIED:20161020T122619Z
UID:95934-1477526400-1477573200@ibecbarcelona.eu
SUMMARY:IBEC PhD Thesis Defence: Oiane Urra
DESCRIPTION:“Analysis of the Interlimb similarity of motor patterns for improving stroke assessment and neurorehabilitation”\nOiane Urra\, Biomedical signal processing and interpretation group\nOiane will be defending her PhD thesis on Thursday 27th at 12:00 at  Facultat d’Informàtica de Barcelona (Sala d’actes)\, Edifici B6 del Campus Nord\, Planta 0 (C/Jordi Girona\, 1-3\, 08034 Barcelona). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-oiane-urra-2/
LOCATION:Sala d’Actes de la Facultat d’Informàtica de Barcelona\, C/Jordi Girona\, 1-3\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161027T000000
DTEND;TZID=Europe/Madrid:20161027T130000
DTSTAMP:20260406T032553
CREATED:20161020T122619Z
LAST-MODIFIED:20161025T013530Z
UID:25210-1477526400-1477573200@ibecbarcelona.eu
SUMMARY:IBEC PhD Thesis Defence: Oiane Urra
DESCRIPTION:“Analysis of the Interlimb similarity of motor patterns for improving stroke assessment and neurorehabilitation”\nOiane Urra\, Biomedical signal processing and interpretation group\nOiane will be defending her PhD thesis on Thursday 27th at 12:00 at  Facultat d’Informàtica de Barcelona (Sala d’actes)\, Edifici B6 del Campus Nord\, Planta 0 (C/Jordi Girona\, 1-3\, 08034 Barcelona). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-oiane-urra/
LOCATION:Sala d’Actes de la Facultat d’Informàtica de Barcelona\, C/Jordi Girona\, 1-3\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161026T100000
DTEND;TZID=Europe/Madrid:20161026T120000
DTSTAMP:20260406T032553
CREATED:20161025T135759Z
LAST-MODIFIED:20170801T110635Z
UID:25278-1477476000-1477483200@ibecbarcelona.eu
SUMMARY:Good practices in a multi-disciplinary lab
DESCRIPTION:Good practices in a multi-disciplinary lab\nThe objective of this workshop is to acquire the good practices necessary in a multidisciplinary laboratory to ensure the highest quality of the results. \nIf you are a Master Student\, Undergraduate Student or you are in your first year of PhD and you want to learn how to work in a multidisciplinary laboratory you need to attend this workshop. \nThe training method will be to follow the process of performing an experiment\, from previous planning until the moment of leaving the benchtop. For this purpose\, we will take into account relevant aspects such as correct use of routine equipment\, dealing with the waste\, keeping a clean and tidy space\, or health and safety. \n\nContents of the course: \n• Introduction\n• Plan and perform an experiment\n• Practical part \nMethodology:\nSessions will be organized in two parts: \n• In the first part\, the trainer will guide us in the use of good practices from the moment a researcher arrives to the benchtop and starts working until the end of the experiment. \n• In the second part\, the trainer will ask you to deal with different daily lab situations in a simulated bench. This part will be highly interactive\, including games and debate discussions. \nNumber of participants: 25.\nLanguage of the course: English \nTrainers:\nIBEC’s Health and Safety Committee members:\nDavid Izquierdo\nAriadna Pérez\nSoledad Pérez\nIsabel Oliveira\nRaquel Guillén \nIf you’d like to attend\, please send an email to hr@ibecbarcelona.eu before 18:00h on October 25th\, including any questions you’d like to discuss. \nAfter receiving all the applications\, our HR Unit will contact you to confirm your acceptance.
URL:https://ibecbarcelona.eu/event/good-practices-in-a-multi-disciplinary-lab/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161026T100000
DTEND;TZID=Europe/Madrid:20161026T120000
DTSTAMP:20260406T032553
CREATED:20161025T135759Z
LAST-MODIFIED:20161025T135759Z
UID:95936-1477476000-1477483200@ibecbarcelona.eu
SUMMARY:Good practices in a multi-disciplinary lab
DESCRIPTION:Good practices in a multi-disciplinary lab\nThe objective of this workshop is to acquire the good practices necessary in a multidisciplinary laboratory to ensure the highest quality of the results. \nIf you are a Master Student\, Undergraduate Student or you are in your first year of PhD and you want to learn how to work in a multidisciplinary laboratory you need to attend this workshop. \nThe training method will be to follow the process of performing an experiment\, from previous planning until the moment of leaving the benchtop. For this purpose\, we will take into account relevant aspects such as correct use of routine equipment\, dealing with the waste\, keeping a clean and tidy space\, or health and safety. \n\nContents of the course: \n• Introduction\n• Plan and perform an experiment\n• Practical part \nMethodology:\nSessions will be organized in two parts: \n• In the first part\, the trainer will guide us in the use of good practices from the moment a researcher arrives to the benchtop and starts working until the end of the experiment. \n• In the second part\, the trainer will ask you to deal with different daily lab situations in a simulated bench. This part will be highly interactive\, including games and debate discussions. \nNumber of participants: 25.\nLanguage of the course: English \nTrainers:\nIBEC’s Health and Safety Committee members:\nDavid Izquierdo\nAriadna Pérez\nSoledad Pérez\nIsabel Oliveira\nRaquel Guillén \nIf you’d like to attend\, please send an email to hr@ibecbarcelona.eu before 18:00h on October 25th\, including any questions you’d like to discuss. \nAfter receiving all the applications\, our HR Unit will contact you to confirm your acceptance.
URL:https://ibecbarcelona.eu/event/good-practices-in-a-multi-disciplinary-lab-2/
CATEGORIES:Professional and Personal Development
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161013T150000
DTEND;TZID=Europe/Madrid:20161013T160000
DTSTAMP:20260406T032553
CREATED:20161006T150918Z
LAST-MODIFIED:20161010T161431Z
UID:24823-1476370800-1476374400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Targeting fibroblast durotaxis as anti-fibrotic therapy
DESCRIPTION:Targeting fibroblast durotaxis as anti-fibrotic therapy\nDr. David Lagares\, Harvard Medical School\nDysregulated wound repair process in response to chronic tissue injury can lead to the development of tissue fibrosis in most organs. Fibrosis is characterized by accumulation of collagens and other matrix proteins that result in the distortion of tissue architecture\, and ultimately organ failure\, in variety of human diseases including idiopathic pulmonary fibrosis (IPF). Tissue stiffening\, traditionally thought to simply be a consequence of lung fibrosis\, has been recently shown to be a contributing factor to its pathogenesis by inducing fibroblasts differentiation into activated myofibroblasts\, the principal effector cells responsible matrix deposition. \nThe cellular and molecular mechanisms through which increased tissue rigidity drives disease progression remain to be fully elucidated. Using atomic force microscopy (AFM) to mechanically characterize the “topography”\, i.e. the spatial distribution\, of alterations in matrix stiffness produced in mouse models of lung fibrosis\, we consistently found that stiffness\, rather than being uniformly elevated in lung fibrotic tissues from animals models\, rises and falls in spatial gradients between “peaks” and “valleys.” We hypothesize that the stiffness “peaks” represent areas in which the fibrotic process was initiated\, or “nucleated”. Once fibrosis is nucleated\, the stiffness gradients leading to these fibrotic peaks are amplified by fibroblast “durotaxis\,” – the directed migration of cells from regions of lower to higher stiffness\, which occurs in the absence of chemoattractant gradients. Using hydrogels that recapitulate the stiffness gradients observed in animal fibrosis models\, we demonstrated durotaxis of lung fibroblasts in time-lapse microscopy studies. In human studies with lung tissues from IPF patients\, AFM revealed similar stiffness topography as we observed in mouse models\, i.e. the presence of focal peaks surrounded by stiffness gradients. Of note\, we have also found that primary lung fibroblasts from IPF patients exhibit greater durotactic responses to stiffness gradients than do control lung fibroblasts. In efforts to identify the molecular pathways involved in cell durotaxis\, we have found that the increased durotaxis of IPF fibroblasts may be attributable\, at least in part\, to increased acetylation of their microtubules. Acetylation of α-tubulin is dependent on α-tubulin acetyltransferase (αTAT1) activity\, which is upregulated in fibrotic fibroblasts compared with controls. siRNA-mediated αTAT1 downregulation in these fibrotic fibroblasts reduced their pro-durotactic phenotype without affecting fibroblast chemotaxis.  In vivo\, αTAT-1-deficient mice were protected from bleomycin-induced lung fibrosis\, as assessed qualitatively by histology and quantitatively by hydroxyproline levels. Together\, we identified a novel mechanism through which gradients of matrix stiffness produced in the injured lung drives the progression of lung fibrosis\, by recruiting additional fibroblasts to sites of injury and incipient fibrosis through durotaxis. We consequently hypothesize that inhibition of fibroblast durotaxis has the potential to be an entirely new therapeutic strategy for IPF and other fibrotic diseases.
URL:https://ibecbarcelona.eu/event/ibec-seminar-targeting-fibroblast-durotaxis-as-anti-fibrotic-therapy/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161013T150000
DTEND;TZID=Europe/Madrid:20161013T160000
DTSTAMP:20260406T032553
CREATED:20161006T150918Z
LAST-MODIFIED:20161006T150918Z
UID:95920-1476370800-1476374400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Targeting fibroblast durotaxis as anti-fibrotic therapy
DESCRIPTION:Targeting fibroblast durotaxis as anti-fibrotic therapy\nDr. David Lagares\, Harvard Medical School\nDysregulated wound repair process in response to chronic tissue injury can lead to the development of tissue fibrosis in most organs. Fibrosis is characterized by accumulation of collagens and other matrix proteins that result in the distortion of tissue architecture\, and ultimately organ failure\, in variety of human diseases including idiopathic pulmonary fibrosis (IPF). Tissue stiffening\, traditionally thought to simply be a consequence of lung fibrosis\, has been recently shown to be a contributing factor to its pathogenesis by inducing fibroblasts differentiation into activated myofibroblasts\, the principal effector cells responsible matrix deposition. \nThe cellular and molecular mechanisms through which increased tissue rigidity drives disease progression remain to be fully elucidated. Using atomic force microscopy (AFM) to mechanically characterize the “topography”\, i.e. the spatial distribution\, of alterations in matrix stiffness produced in mouse models of lung fibrosis\, we consistently found that stiffness\, rather than being uniformly elevated in lung fibrotic tissues from animals models\, rises and falls in spatial gradients between “peaks” and “valleys.” We hypothesize that the stiffness “peaks” represent areas in which the fibrotic process was initiated\, or “nucleated”. Once fibrosis is nucleated\, the stiffness gradients leading to these fibrotic peaks are amplified by fibroblast “durotaxis\,” – the directed migration of cells from regions of lower to higher stiffness\, which occurs in the absence of chemoattractant gradients. Using hydrogels that recapitulate the stiffness gradients observed in animal fibrosis models\, we demonstrated durotaxis of lung fibroblasts in time-lapse microscopy studies. In human studies with lung tissues from IPF patients\, AFM revealed similar stiffness topography as we observed in mouse models\, i.e. the presence of focal peaks surrounded by stiffness gradients. Of note\, we have also found that primary lung fibroblasts from IPF patients exhibit greater durotactic responses to stiffness gradients than do control lung fibroblasts. In efforts to identify the molecular pathways involved in cell durotaxis\, we have found that the increased durotaxis of IPF fibroblasts may be attributable\, at least in part\, to increased acetylation of their microtubules. Acetylation of α-tubulin is dependent on α-tubulin acetyltransferase (αTAT1) activity\, which is upregulated in fibrotic fibroblasts compared with controls. siRNA-mediated αTAT1 downregulation in these fibrotic fibroblasts reduced their pro-durotactic phenotype without affecting fibroblast chemotaxis.  In vivo\, αTAT-1-deficient mice were protected from bleomycin-induced lung fibrosis\, as assessed qualitatively by histology and quantitatively by hydroxyproline levels. Together\, we identified a novel mechanism through which gradients of matrix stiffness produced in the injured lung drives the progression of lung fibrosis\, by recruiting additional fibroblasts to sites of injury and incipient fibrosis through durotaxis. We consequently hypothesize that inhibition of fibroblast durotaxis has the potential to be an entirely new therapeutic strategy for IPF and other fibrotic diseases.
URL:https://ibecbarcelona.eu/event/ibec-seminar-targeting-fibroblast-durotaxis-as-anti-fibrotic-therapy-2/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161013T100000
DTEND;TZID=Europe/Madrid:20161013T110000
DTSTAMP:20260406T032553
CREATED:20161007T133132Z
LAST-MODIFIED:20161007T133132Z
UID:95921-1476352800-1476356400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Scaling up in Systems Biology: from a minimal cell to microbiomes
DESCRIPTION:Scaling up in Systems Biology: from a minimal cell to microbiomes\nMaria Lluch Senar\, Design of Biological Systems grup\, Centre for Genomic Regulation (CRG)\nUltra-sequencing technologies have allowed the massive identification of human-associated microbiomes. Genome annotations of microbiomes consider conserved ORFs or those encoding for proteins larger than 100aa. However\, growing evidence highlight the existence of a hidden universe of small genes (smORFs) encoding for small peptides (SEPs; <100aa)\, many of them secreted\, being involved in infection and quorum sensing. Also\, in eukaryotes\, small antimicrobial peptides (AMPs) are secreted in response to infection. The interplay between these secreted SEPs is essential to control the different human microbiomes to ensure coexistence rather than weakening the host against opportunistic infections. Thus\, determining the smORFome of bacterial-host ecosystems and studying its role in homeostasis are essential. In this seminar\, I will explain how by using different system biology approaches we discovered this layer of small peptides in Mycoplasma pneumoniae and our future plans to study their role in human microbiomes focusing in female reproductive tract.
URL:https://ibecbarcelona.eu/event/ibec-seminar-scaling-up-in-systems-biology-from-a-minimal-cell-to-microbiomes-2/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161013T100000
DTEND;TZID=Europe/Madrid:20161013T110000
DTSTAMP:20260406T032553
CREATED:20161007T133132Z
LAST-MODIFIED:20161010T161238Z
UID:24827-1476352800-1476356400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Scaling up in Systems Biology: from a minimal cell to microbiomes
DESCRIPTION:Scaling up in Systems Biology: from a minimal cell to microbiomes\nMaria Lluch Senar\, Design of Biological Systems grup\, Centre for Genomic Regulation (CRG)\nUltra-sequencing technologies have allowed the massive identification of human-associated microbiomes. Genome annotations of microbiomes consider conserved ORFs or those encoding for proteins larger than 100aa. However\, growing evidence highlight the existence of a hidden universe of small genes (smORFs) encoding for small peptides (SEPs; <100aa)\, many of them secreted\, being involved in infection and quorum sensing. Also\, in eukaryotes\, small antimicrobial peptides (AMPs) are secreted in response to infection. The interplay between these secreted SEPs is essential to control the different human microbiomes to ensure coexistence rather than weakening the host against opportunistic infections. Thus\, determining the smORFome of bacterial-host ecosystems and studying its role in homeostasis are essential. In this seminar\, I will explain how by using different system biology approaches we discovered this layer of small peptides in Mycoplasma pneumoniae and our future plans to study their role in human microbiomes focusing in female reproductive tract.
URL:https://ibecbarcelona.eu/event/ibec-seminar-scaling-up-in-systems-biology-from-a-minimal-cell-to-microbiomes/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161011T190000
DTEND;TZID=Europe/Madrid:20161011T200000
DTSTAMP:20260406T032553
CREATED:20161010T084327Z
LAST-MODIFIED:20170801T130439Z
UID:24874-1476212400-1476216000@ibecbarcelona.eu
SUMMARY:Conferència: La regeneració d'òrgans com a paradigma de la medicina del futur
DESCRIPTION:Conferència: La regeneració d’òrgans com a paradigma de la medicina del futur\nDra. Elisabeth Engel\, cap del Grup de Biomaterials per a Teràpies Regeneratives de l’IBEC i professora agregada de la UPC\nCaixaForum Girona. Dimarts 11 d’octubre del 2016 a les 19 h \nEn el passat\, la idea d’un home biònic ha estat només cosa de la ficció: Frankenstein n’és l’exemple. Però\, avui dia\, no sembla tan increïble que la tecnologia pugui igualar\, o fins i tot sobrepassar\, les capacitats del cos humà. Els investigadors de l’IBEC s’estan enfrontant a un ampli ventall de desafiaments en enginyeria de teixits. Alguns dels nostres científics s’especialitzen en teixit ossi\, vascular i neuronal i altres busquen regenerar òrgans sencers com el cor. L’enginyeria de teixits podria proporcionar un mitjà per substituir parts del cos danyades o malaltes utilitzant les cèl·lules del pacient mateix\, per evitar així les llargues llistes d’espera i el risc de rebuig que tenen actualment els trasplantaments. \nMés informació i registre
URL:https://ibecbarcelona.eu/event/conferencia-la-regeneracio-dorgans-com-a-paradigma-de-la-medicina-del-futur/
LOCATION:CaixaForum Girona
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161011T190000
DTEND;TZID=Europe/Madrid:20161011T200000
DTSTAMP:20260406T032553
CREATED:20161010T084327Z
LAST-MODIFIED:20161010T084327Z
UID:95922-1476212400-1476216000@ibecbarcelona.eu
SUMMARY:Conferència: La regeneració d'òrgans com a paradigma de la medicina del futur
DESCRIPTION:Conferència: La regeneració d’òrgans com a paradigma de la medicina del futur\nDra. Elisabeth Engel\, cap del Grup de Biomaterials per a Teràpies Regeneratives de l’IBEC i professora agregada de la UPC\nCaixaForum Girona. Dimarts 11 d’octubre del 2016 a les 19 h \nEn el passat\, la idea d’un home biònic ha estat només cosa de la ficció: Frankenstein n’és l’exemple. Però\, avui dia\, no sembla tan increïble que la tecnologia pugui igualar\, o fins i tot sobrepassar\, les capacitats del cos humà. Els investigadors de l’IBEC s’estan enfrontant a un ampli ventall de desafiaments en enginyeria de teixits. Alguns dels nostres científics s’especialitzen en teixit ossi\, vascular i neuronal i altres busquen regenerar òrgans sencers com el cor. L’enginyeria de teixits podria proporcionar un mitjà per substituir parts del cos danyades o malaltes utilitzant les cèl·lules del pacient mateix\, per evitar així les llargues llistes d’espera i el risc de rebuig que tenen actualment els trasplantaments. \nMés informació i registre
URL:https://ibecbarcelona.eu/event/conferencia-la-regeneracio-dorgans-com-a-paradigma-de-la-medicina-del-futur-2/
LOCATION:CaixaForum Girona
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161010T150000
DTEND;TZID=Europe/Madrid:20161010T160000
DTSTAMP:20260406T032553
CREATED:20160928T191705Z
LAST-MODIFIED:20160930T122011Z
UID:24759-1476111600-1476115200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Publishing in the Nature journals
DESCRIPTION:IBEC Seminar: Publishing in the Nature journals\nDr. Alexia-Ileana Zaromytidou (Chief Editor\, Nature Cell Biology)\nAlexia-Ileana Zaromytidou\, Chief Editor of Nature Cell Biology will provide an editor’s perspective on the editorial and publishing process in the Nature journals.\nShe received her PhD from the London Research Institute of Cancer Research UK in London\, UK (now the Francis Crick Institute) in January 2007. Her doctoral work with Richard Treisman centered on the molecular interactions between actin-regulated transcription factors and their coactivators in the context of MAPK and Rho signaling responses. She pursued her postdoctoral research in the lab of Joan Massagué at Memorial Sloan-Kettering Cancer Center in New York\, where she studied how different phosphorylation inputs affect TGFβ/BMP pathway activity to achieve distinct biological outcomes. In September 2010 she joined the editorial team of Nature Cell Biology as the editor responsible for the areas of cancer biology\, mechanobiology\, cell adhesion\, migration and the cytoskeleton\, and became Chief editor of the journal in November 2015.
URL:https://ibecbarcelona.eu/event/24759/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161010T150000
DTEND;TZID=Europe/Madrid:20161010T160000
DTSTAMP:20260406T032553
CREATED:20160928T191705Z
LAST-MODIFIED:20160928T191705Z
UID:95918-1476111600-1476115200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Publishing in the Nature journals
DESCRIPTION:IBEC Seminar: Publishing in the Nature journals\nDr. Alexia-Ileana Zaromytidou (Chief Editor\, Nature Cell Biology)\nAlexia-Ileana Zaromytidou\, Chief Editor of Nature Cell Biology will provide an editor’s perspective on the editorial and publishing process in the Nature journals.\nShe received her PhD from the London Research Institute of Cancer Research UK in London\, UK (now the Francis Crick Institute) in January 2007. Her doctoral work with Richard Treisman centered on the molecular interactions between actin-regulated transcription factors and their coactivators in the context of MAPK and Rho signaling responses. She pursued her postdoctoral research in the lab of Joan Massagué at Memorial Sloan-Kettering Cancer Center in New York\, where she studied how different phosphorylation inputs affect TGFβ/BMP pathway activity to achieve distinct biological outcomes. In September 2010 she joined the editorial team of Nature Cell Biology as the editor responsible for the areas of cancer biology\, mechanobiology\, cell adhesion\, migration and the cytoskeleton\, and became Chief editor of the journal in November 2015.
URL:https://ibecbarcelona.eu/event/24759-2/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161010T091500
DTEND;TZID=Europe/Madrid:20161010T120000
DTSTAMP:20260406T032553
CREATED:20160930T122006Z
LAST-MODIFIED:20161025T014501Z
UID:24783-1476090900-1476100800@ibecbarcelona.eu
SUMMARY:Complementary Skills Session: Career progression in science: options beyond the bench
DESCRIPTION:Complementary Skills Session: Career progression in science: options beyond the bench\nTogether with the Barcelona Science Park (PCB) and the Institute for Research in Biomedicine (IRB)\, we have organized a Round table on “Career progression in science – options beyond the bench”\, in order to give our PhD students and postdocs the opportunity to discover new and exciting career options from the experience of successful professionals. \nYou can have a look at the programme and speakers \nComplementary Skills Sessions are open to all staff and researchers at all career stages.
URL:https://ibecbarcelona.eu/event/complementary-skills-session-on-10th-october-career-progression-in-science-options-beyond-the-bench/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161010T091500
DTEND;TZID=Europe/Madrid:20161010T120000
DTSTAMP:20260406T032553
CREATED:20160930T122006Z
LAST-MODIFIED:20160930T122006Z
UID:95919-1476090900-1476100800@ibecbarcelona.eu
SUMMARY:Complementary Skills Session: Career progression in science: options beyond the bench
DESCRIPTION:Complementary Skills Session: Career progression in science: options beyond the bench\nTogether with the Barcelona Science Park (PCB) and the Institute for Research in Biomedicine (IRB)\, we have organized a Round table on “Career progression in science – options beyond the bench”\, in order to give our PhD students and postdocs the opportunity to discover new and exciting career options from the experience of successful professionals. \nYou can have a look at the programme and speakers \nComplementary Skills Sessions are open to all staff and researchers at all career stages.
URL:https://ibecbarcelona.eu/event/complementary-skills-session-on-10th-october-career-progression-in-science-options-beyond-the-bench-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161006T080000
DTEND;TZID=Europe/Madrid:20161007T170000
DTSTAMP:20260406T032553
CREATED:20160713T190628Z
LAST-MODIFIED:20160713T190628Z
UID:95917-1475740800-1475859600@ibecbarcelona.eu
SUMMARY:Mechanobiology Across Networks
DESCRIPTION:Mechanobiology Across Networks\nJoint Meeting of the Spanish Network of Excellence in Mechanobiology and the European Innovative Training Network BIOPOL \nBy factoring the role not only of biochemical but also of mechanical signals\, the emerging discipline of Mechanobiology is reshaping our understanding of molecules\, cells\, and tissues. This meeting brings together two networks dedicated to this blooming topic: the Spanish Network of Excellence in Mechanobiology\, and the European Training Network BIOPOL. The meeting will feature talks and poster presentations from both senior and junior members of both networks\, and will address fundamental and applied questions in mechanobiology from the perspectives of physics\, biology\, and engineering. The meeting is also open for attendance to anyone interested in the topic.\n \nImportant deadlines:\nAbstract submission: 21st June\nNotification of acceptance: 6th July – 21st July\nRegistration deadline: 16th September \nFor more details and to register\, visit http://ibecbarcelona.eu/events/Mechanobiology_across_networks \n 
URL:https://ibecbarcelona.eu/event/mechanobiology-across-networks-2/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161006T080000
DTEND;TZID=Europe/Madrid:20161007T170000
DTSTAMP:20260406T032553
CREATED:20160713T190628Z
LAST-MODIFIED:20170801T110723Z
UID:23984-1475740800-1475859600@ibecbarcelona.eu
SUMMARY:Mechanobiology Across Networks
DESCRIPTION:Mechanobiology Across Networks\nJoint Meeting of the Spanish Network of Excellence in Mechanobiology and the European Innovative Training Network BIOPOL \nBy factoring the role not only of biochemical but also of mechanical signals\, the emerging discipline of Mechanobiology is reshaping our understanding of molecules\, cells\, and tissues. This meeting brings together two networks dedicated to this blooming topic: the Spanish Network of Excellence in Mechanobiology\, and the European Training Network BIOPOL. The meeting will feature talks and poster presentations from both senior and junior members of both networks\, and will address fundamental and applied questions in mechanobiology from the perspectives of physics\, biology\, and engineering. The meeting is also open for attendance to anyone interested in the topic.\n \nImportant deadlines:\nAbstract submission: 21st June\nNotification of acceptance: 6th July – 21st July\nRegistration deadline: 16th September \nFor more details and to register\, visit https://ibecbarcelona.eu/events/Mechanobiology_across_networks \n 
URL:https://ibecbarcelona.eu/event/mechanobiology-across-networks/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160715T110000
DTEND;TZID=Europe/Madrid:20160715T130000
DTSTAMP:20260406T032553
CREATED:20160711T161150Z
LAST-MODIFIED:20160711T161150Z
UID:23969-1468580400-1468587600@ibecbarcelona.eu
SUMMARY:IBEC PhD Thesis Defence: Manuel Lozano
DESCRIPTION:“Multichannel analysis of normal and continuous adventitious respiratory sounds for the assessment of pulmonary function in respiratory diseases”\nManuel Lozano\, Biomedical Signal Processing and Interpretation group\nManuel will be defending his PhD thesis on Friday 15th July at 11:00 at the Facultat de Matemàtiques i Estadística (Sala d’Actes) of the UPC (c. Pau Gargallo\, 5 08028 Barcelona). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-manuel-lozano/
LOCATION:Sala d’Actes de la Facultat de Matemàtiques i Estadística\, c. Pau Gargallo 5\, 08028 Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160715T110000
DTEND;TZID=Europe/Madrid:20160715T130000
DTSTAMP:20260406T032553
CREATED:20160711T161150Z
LAST-MODIFIED:20160711T161150Z
UID:95916-1468580400-1468587600@ibecbarcelona.eu
SUMMARY:IBEC PhD Thesis Defence: Manuel Lozano
DESCRIPTION:“Multichannel analysis of normal and continuous adventitious respiratory sounds for the assessment of pulmonary function in respiratory diseases”\nManuel Lozano\, Biomedical Signal Processing and Interpretation group\nManuel will be defending his PhD thesis on Friday 15th July at 11:00 at the Facultat de Matemàtiques i Estadística (Sala d’Actes) of the UPC (c. Pau Gargallo\, 5 08028 Barcelona). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-manuel-lozano-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtiques i Estadística\, c. Pau Gargallo 5\, 08028 Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260406T032553
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:22777-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-shulamit-levenberg/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260406T032553
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:95913-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-shulamit-levenberg-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160708T100000
DTEND;TZID=Europe/Madrid:20160708T110000
DTSTAMP:20260406T032553
CREATED:20160705T171136Z
LAST-MODIFIED:20160705T171136Z
UID:23873-1467972000-1467975600@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Pilar Rodríguez and Montserrat López
DESCRIPTION:Long-ranged force patterns and waves during the formation and maintenance of repulsive epithelial barriers\nPilar Rodríguez Franco\, Integrative cell and tissue dynamics group\nFor an organism to develop and maintain homeostasis\, cell types with distinct functions must often be separated by physical boundaries. A prevalent mechanism for the formation and maintenance of such boundaries is the repulsive interaction between Eph receptor tyrosine kinases and their ligands Ephrins. Upon contact\, cells expressing Eph and Ephrin trigger diverse local mechanisms that prevent intercellular adhesion\, including receptor endocytosis\, extracellular cadherin cleavage\, and local contractility. Here we show that\, besides these local subcellular mechanisms\, Eph/Ephrin boundary formation involves cooperative physical forces generated by cells located many rows behind the boundary. Contact between two epithelial monolayers\, one expressing Eph and one expressing Ephrin\, results in the buildup of two supracellular acto-myosin cables that line epithelial edges at both sides of the boundary. Besides these cables\, both monolayers exhibit long-lived periodic patterns of traction forces that expand several cell rows and tend to pull the monolayer away from the boundary\, thereby contributing to sustain tissue segregation. The formation of these patterns is paralleled by the generation of soliton-like deformation waves that propagate away from the boundary. Finally\, we show that periodic traction patterns and mechanical waves are observed not only during Eph/Ephrin repulsion but also during formation of diverse types of barriers. Our findings thus unveil a global physical mechanism that sustains tissue separation. \n  \nNanoscale Conductance mapping of redox proteins\nMontserrat López Martínez\, Nanoprobes and nanoswitches group\nElectron Transfer (ET) plays essential roles in crucial biological processes such as cell respiration and photosynthesis. It takes place between redox proteins and in protein complexes that display an outstanding efficiency and environmental adaptability. Although the fundamental aspects of ET processes are well understood\, more experimental methods are needed to determine electronic pathways in these redox protein structures. Understanding how ET works is important not only for fundamental reasons\, but also for the potential technological applications of these redox-active nanoscale systems.\nElectrochemical Scanning Tunneling Microscopy (ECSTM) is an excellent tool to study redox molecules including proteins. It offers single molecule resolution and allows working in nearly physiological conditions\, with full electrochemical control. Beyond imaging\, ECSTM allows performing current-voltage and current-distance tunneling spectroscopy. We adapted the current-voltage spectroscopy mode of ECSTM to obtain simultaneous topographic and differential conductance images under potentiostatic control. After validation of the method we applied it to the study of the redox protein Azurin immobilized on to a Au  surface\, a model system to study biological ET processes.
URL:https://ibecbarcelona.eu/event/phd-discussion-session-pilar-rodriguez-and-montserrat-lopez/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20160708T100000
DTEND;TZID=Europe/Madrid:20160708T110000
DTSTAMP:20260406T032553
CREATED:20160705T171136Z
LAST-MODIFIED:20160705T171136Z
UID:95915-1467972000-1467975600@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Pilar Rodríguez and Montserrat López
DESCRIPTION:Long-ranged force patterns and waves during the formation and maintenance of repulsive epithelial barriers\nPilar Rodríguez Franco\, Integrative cell and tissue dynamics group\nFor an organism to develop and maintain homeostasis\, cell types with distinct functions must often be separated by physical boundaries. A prevalent mechanism for the formation and maintenance of such boundaries is the repulsive interaction between Eph receptor tyrosine kinases and their ligands Ephrins. Upon contact\, cells expressing Eph and Ephrin trigger diverse local mechanisms that prevent intercellular adhesion\, including receptor endocytosis\, extracellular cadherin cleavage\, and local contractility. Here we show that\, besides these local subcellular mechanisms\, Eph/Ephrin boundary formation involves cooperative physical forces generated by cells located many rows behind the boundary. Contact between two epithelial monolayers\, one expressing Eph and one expressing Ephrin\, results in the buildup of two supracellular acto-myosin cables that line epithelial edges at both sides of the boundary. Besides these cables\, both monolayers exhibit long-lived periodic patterns of traction forces that expand several cell rows and tend to pull the monolayer away from the boundary\, thereby contributing to sustain tissue segregation. The formation of these patterns is paralleled by the generation of soliton-like deformation waves that propagate away from the boundary. Finally\, we show that periodic traction patterns and mechanical waves are observed not only during Eph/Ephrin repulsion but also during formation of diverse types of barriers. Our findings thus unveil a global physical mechanism that sustains tissue separation. \n  \nNanoscale Conductance mapping of redox proteins\nMontserrat López Martínez\, Nanoprobes and nanoswitches group\nElectron Transfer (ET) plays essential roles in crucial biological processes such as cell respiration and photosynthesis. It takes place between redox proteins and in protein complexes that display an outstanding efficiency and environmental adaptability. Although the fundamental aspects of ET processes are well understood\, more experimental methods are needed to determine electronic pathways in these redox protein structures. Understanding how ET works is important not only for fundamental reasons\, but also for the potential technological applications of these redox-active nanoscale systems.\nElectrochemical Scanning Tunneling Microscopy (ECSTM) is an excellent tool to study redox molecules including proteins. It offers single molecule resolution and allows working in nearly physiological conditions\, with full electrochemical control. Beyond imaging\, ECSTM allows performing current-voltage and current-distance tunneling spectroscopy. We adapted the current-voltage spectroscopy mode of ECSTM to obtain simultaneous topographic and differential conductance images under potentiostatic control. After validation of the method we applied it to the study of the redox protein Azurin immobilized on to a Au  surface\, a model system to study biological ET processes.
URL:https://ibecbarcelona.eu/event/phd-discussion-session-pilar-rodriguez-and-montserrat-lopez-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160629T080000
DTEND;TZID=UTC:20160629T170000
DTSTAMP:20260406T032553
CREATED:20160307T101152Z
LAST-MODIFIED:20160503T105243Z
UID:21815-1467187200-1467219600@ibecbarcelona.eu
SUMMARY:9th IBEC Symposium
DESCRIPTION:9th IBEC Symposium: Bioengineering for Active Ageing\nWednesday 29th June 2016\nPlease save the date for the 9th IBEC Symposium on Bioengineering for Active Ageing\, which will take place on Wednesday 29th June 2016. \nThis year\, the IBEC Symposium will focus on one of our three areas of applications for bioengineering\, Active Ageing\, and will bring together high-profile international experts in our fields of expertise. It provides an open forum for interdisciplinary discussions and networking\, benefitting young researchers and established scientists alike. \nMore information at www.ibecbarcelona.eu/events/Symposium2016. \n[br] \nUseful dates:\nDeadline for abstracts: 23rd May 2016\nRegistration deadline: 19th June 2016
URL:https://ibecbarcelona.eu/event/save-the-date-9th-ibec-symposium/
LOCATION:AXA Auditorium\, L'illa Diagonal\, Av. Diagonal 547 \, Barcelona\, 08029
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160629T080000
DTEND;TZID=UTC:20160629T170000
DTSTAMP:20260406T032553
CREATED:20160307T101152Z
LAST-MODIFIED:20160307T101152Z
UID:95899-1467187200-1467219600@ibecbarcelona.eu
SUMMARY:9th IBEC Symposium
DESCRIPTION:9th IBEC Symposium: Bioengineering for Active Ageing\nWednesday 29th June 2016\nPlease save the date for the 9th IBEC Symposium on Bioengineering for Active Ageing\, which will take place on Wednesday 29th June 2016. \nThis year\, the IBEC Symposium will focus on one of our three areas of applications for bioengineering\, Active Ageing\, and will bring together high-profile international experts in our fields of expertise. It provides an open forum for interdisciplinary discussions and networking\, benefitting young researchers and established scientists alike. \nMore information at www.ibecbarcelona.eu/events/Symposium2016. \n[br] \nUseful dates:\nDeadline for abstracts: 23rd May 2016\nRegistration deadline: 19th June 2016
URL:https://ibecbarcelona.eu/event/save-the-date-9th-ibec-symposium-2/
LOCATION:AXA Auditorium\, L'illa Diagonal\, Av. Diagonal 547 \, Barcelona\, 08029
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160527T100000
DTEND;TZID=UTC:20160527T110000
DTSTAMP:20260406T032553
CREATED:20160415T062711Z
LAST-MODIFIED:20160520T055544Z
UID:22419-1464343200-1464346800@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Elisabet Martí and Maria Valls
DESCRIPTION:Amphoteric polyamidoamines as innovative tools to selectively direct antimalarial drug towards Plasmodium-infected red blood cells\nElisabet Martí\, Nanomalaria joint group\nMalaria\, caused by the protist Plasmodium spp.\, in 2015 alone claimed the lives of more than 400\,000 people\, mainly young African children\, and it had been responsible for 214 million new cases. Despite a significant decrease in the number of malaria-related deaths\, there is still a need for new therapeutic strategies such as finding new antimalarial drugs or substantially improving old ones\, by decreasing side effects and avoiding resistance appearance. The development of highly specific and efficient targeted nanocarriers can be the engine of this change\, which however needs to be done at an affordable cost for malaria endemic countries. \nFour different polyamidoamine (PAA) polymers are being studied in our group with the aim of developing a targeted nanovector capable of reaching in the mid term the preclinical pipeline. \nThe PAA AGMA1 had shown in previous studies antimalarial activity per se at non-toxic concentrations\, as well as certain specificity for pRBCs vs. RBCs. We are trying to elucidate the corresponding mechanisms by characterizing the interaction between AGMA1 and pRBCs. Experiments such as targeting and growth inhibition assays in vitro\, antimalarial activity in vivo and determination of encapsulation capacity are being currently performedwith AGMA1and with three other PAAs: ISA23\, ISA1 and ARGO7. Preliminary results suggest the capacity of AGMA1 to activate the immune system\, indicating that PAAs could be eventually used as an agent with double activity as a drug nanocarrier and as a prophylactic agent. \n  \nDevelopment of a Biomimetic Bioreactor for Cardiac Tissue Engineering Applications\nMaria Valls\, Biomimetic systems for cell engineering group\nIschemic heart disease is a major cause of human death worldwide owing to the heart’s minimal ability to repair following injury. Therefore\, shedding light on heart regeneration and its possible application in medicine is of paramount interest for the scientific community. In this sense\, cardiac tissue engineering aims at obtaining cardiac patches for regenerative medicine purposes. In addition\, these patches could serve as valuable in vitro models to study heart development and regeneration\, heart diseases or as drug screening platforms. \nA prerequisite for obtaining faithful cardiac patches is to mimic the native cardiac environment. Although major advances have been done\, the generation of mature tissue constructs from human induced pluripotent stem (hiPS) cells is still a challenge. To address this\, we have developed a parallelized perfusion bioreactor system and characterized a collagen-based 3D scaffold. Also\, we have designed a perfusion chamber including graphite electrodes to electrically stimulate cells during culture. With this setup\, we have obtained contractile cardiac tissue constructs from primary cultures of neonatal rat heart ventricles that show an enhanced response when cultured under electrical stimulation. \nWe are currently culturing cardiac progenitors derived from hiPS cells\, to produce useful human cardiac tissue surrogates to study cardiovascular tissue maturation as well as for drug/toxicity testing.
URL:https://ibecbarcelona.eu/event/phd-discussion-session-elisabet-marti-and-maria-valls/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160527T100000
DTEND;TZID=UTC:20160527T110000
DTSTAMP:20260406T032553
CREATED:20160415T062711Z
LAST-MODIFIED:20160415T062711Z
UID:95907-1464343200-1464346800@ibecbarcelona.eu
SUMMARY:PhD Discussion Session: Elisabet Martí and Maria Valls
DESCRIPTION:Amphoteric polyamidoamines as innovative tools to selectively direct antimalarial drug towards Plasmodium-infected red blood cells\nElisabet Martí\, Nanomalaria joint group\nMalaria\, caused by the protist Plasmodium spp.\, in 2015 alone claimed the lives of more than 400\,000 people\, mainly young African children\, and it had been responsible for 214 million new cases. Despite a significant decrease in the number of malaria-related deaths\, there is still a need for new therapeutic strategies such as finding new antimalarial drugs or substantially improving old ones\, by decreasing side effects and avoiding resistance appearance. The development of highly specific and efficient targeted nanocarriers can be the engine of this change\, which however needs to be done at an affordable cost for malaria endemic countries. \nFour different polyamidoamine (PAA) polymers are being studied in our group with the aim of developing a targeted nanovector capable of reaching in the mid term the preclinical pipeline. \nThe PAA AGMA1 had shown in previous studies antimalarial activity per se at non-toxic concentrations\, as well as certain specificity for pRBCs vs. RBCs. We are trying to elucidate the corresponding mechanisms by characterizing the interaction between AGMA1 and pRBCs. Experiments such as targeting and growth inhibition assays in vitro\, antimalarial activity in vivo and determination of encapsulation capacity are being currently performedwith AGMA1and with three other PAAs: ISA23\, ISA1 and ARGO7. Preliminary results suggest the capacity of AGMA1 to activate the immune system\, indicating that PAAs could be eventually used as an agent with double activity as a drug nanocarrier and as a prophylactic agent. \n  \nDevelopment of a Biomimetic Bioreactor for Cardiac Tissue Engineering Applications\nMaria Valls\, Biomimetic systems for cell engineering group\nIschemic heart disease is a major cause of human death worldwide owing to the heart’s minimal ability to repair following injury. Therefore\, shedding light on heart regeneration and its possible application in medicine is of paramount interest for the scientific community. In this sense\, cardiac tissue engineering aims at obtaining cardiac patches for regenerative medicine purposes. In addition\, these patches could serve as valuable in vitro models to study heart development and regeneration\, heart diseases or as drug screening platforms. \nA prerequisite for obtaining faithful cardiac patches is to mimic the native cardiac environment. Although major advances have been done\, the generation of mature tissue constructs from human induced pluripotent stem (hiPS) cells is still a challenge. To address this\, we have developed a parallelized perfusion bioreactor system and characterized a collagen-based 3D scaffold. Also\, we have designed a perfusion chamber including graphite electrodes to electrically stimulate cells during culture. With this setup\, we have obtained contractile cardiac tissue constructs from primary cultures of neonatal rat heart ventricles that show an enhanced response when cultured under electrical stimulation. \nWe are currently culturing cardiac progenitors derived from hiPS cells\, to produce useful human cardiac tissue surrogates to study cardiovascular tissue maturation as well as for drug/toxicity testing.
URL:https://ibecbarcelona.eu/event/phd-discussion-session-elisabet-marti-and-maria-valls-2/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160526T100000
DTEND;TZID=UTC:20160526T110000
DTSTAMP:20260406T032553
CREATED:20160520T054234Z
LAST-MODIFIED:20160520T054234Z
UID:22935-1464256800-1464260400@ibecbarcelona.eu
SUMMARY:IBEC seminar: Isaac Gállego
DESCRIPTION:DNA Nanotechnology: from its Applications to the Self-Assembly in Alternative Solvents\nIsaac Gállego\, Georgia Institute of Technology\, USA\nDNA nanotechnology is a relatively new field that utilizes the DNA’s programmability and self-assembly properties to build custom-designed shapes at the nanometer scale. A common implementation is the DNA origami method\, in which a M13 single stranded genome (scaffold) is folded by hundreds of complementary base-paired oligonucleotides (staples). DNA nanostructures have been successfully utilized to create two-dimensional and three-dimensional devices with applications in lithography\, photonics\, electronics\, and the fabrication of inorganic materials. Herein\, I will present to you my work on DNA nanotechnology\, which includes: i) the development of a biosensor to dsiplay the DNA repair activity hAGT—an enzyme target for the development of cancer therapeutics;1 ii) the transfer a pre-programmed nanosclae pattern of DNA onto gold surfaces\, a challenging process useful for the fabrication of functional materials; and iii) the first study of self-assembly of DNA nanostructures in a non-aqueous\, alternative solvent\, a deep eutectic solvent composed of glycerol and choline chloride in a 4:1 molar ratio (glycholine).2 Glycholine and its hydrated mixtures facilitate DNA folding by alleviating kinetic traps that are often encountered during the folding of DNA structures in aqueous solvent. \n1. Tintoré\, M.\, Gállego\, I.\, Manning\, B.\, Eritja\, R. & Fàbrega\, C. DNA Origami as a DNA Repair Nanosensor at the Single‐Molecule Level. Angew. Chem. Int. Ed. Engl. 52\, 7747–7750\n2. Gállego\, I.\, Grover\, M. A. & Hud\, N. V. Folding and Imaging of DNA Nanostructures in Anhydrous and Hydrated Deep-Eutectic Solvents. Angew. Chem. Int. Ed. Engl. 54\, 6765–6769 (2015).
URL:https://ibecbarcelona.eu/event/ibec-seminar-isaac-gallego/
CATEGORIES:IBEC Seminar
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