BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T120000
DTEND;TZID=Europe/Madrid:20230428T133000
DTSTAMP:20260403T213252
CREATED:20230309T155632Z
LAST-MODIFIED:20230426T104601Z
UID:105698-1682683200-1682688600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Charles Baroud
DESCRIPTION:Modeling immune-cancer interactions using a microfluidic 3D culture approach\nCharles Baroud\, Professor at Ecole Polytechnique\, France\nLab head at Institut Pasteur\, Paris\, France \nCancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach\, which has shown some remarkable successes\, leverages the patient’s own immune cells to locate and attack the tumor cells. However the method suffers from large heterogeneities in outcomes between different patients\, in part due to the the number\, phenotype\, and distribution of cytotoxic T cells (CTLs) around the tumor cells. For this reason decoding the collective behavior of CTLs\, as they recognize and attack cancer cells\, is a major challenge that requires advanced in vitro models. This seminar will present a microfluidic platform that enables quantitative measurements of the spatiotemporal dynamics of individual CTLs as they migrate in three-dimensional (3D) environments and attack cancer spheroids. The method provides access to the trajectories of thousands of cells around hundreds of spheroids\, which in turn enables probabilistic modeling of the trajectories. Analysis of the migration and killing events allows us to dissect the different phases of interactions and to identify limiting steps for different conditions. The talk will present the microfluidics and then shift focus to different biological models\, with implications for both fundamental biology and for personalized medicine. \n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-charles-baroud/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T100000
DTEND;TZID=Europe/Madrid:20230428T110000
DTSTAMP:20260403T213252
CREATED:20230420T113916Z
LAST-MODIFIED:20250306T162535Z
UID:107325-1682676000-1682679600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Ainoa Tejedera and Zarina Nauryzgaliyeva
DESCRIPTION:Mimicking Sarcolemmal Damage In vitro: A 3D Skeletal Muscle Model for Drug Testing in Duchenne Muscular Dystrophy\nAinoa Tejedera Villafranca\, Biosensors for bioengineering group \nDuchenne muscular dystrophy (DMD) is the most prevalent neuromuscular disease diagnosed in childhood. It is a progressive and wasting disease\, characterized by a degeneration of skeletal and cardiac muscles caused by the lack of dystrophin protein. The absence of this structural protein leads to the fragility of the sarcolemma\, and muscle fibers are damaged during their contraction. To date\, there is no cure available for patients\, even though there are several molecules in drug development. However\, due to the well-known limitations of preclinical research\, the success rate of drugs remains low. In this work\, intending to accelerate drug discovery for DMD\, we developed a patient-derived functional 3D model of DMD. By using a 3D-printed casting mold\, we encapsulated muscle progenitor cells in a fibrin-composite matrix. This platform incorporates two flexible T-shaped pillars that serve as anchoring points and provide continuous tension to the tissue\, thus allowing the orientation of the muscle fibers. The skeletal muscle tissues expressed mature myogenic markers and showed functional phenotypes as they responded to electrical pulse stimulation (EPS) by contracting. We observed that DMD muscle tissues\, after continuous contractile regimes\, reproduced the loss of myotube integrity that is observed in dystrophinopathies due to the sarcolemmal instability. DMD but not healthy tissues showed functional phenotypes caused by the induced sarcolemmal damage\, such as tetanic fatigue. Finally\, the applicability of this DMD model in evaluating therapeutic compounds was explored. Specifically\, we investigate the effect of utrophin up-regulators on functional outcomes of the model\, thus identifying potential candidates for the treatment of DMD. Taking all these considerations together\, our results show that bioengineered 3D skeletal muscle technology has great potential to be especially valuable in the context of current and future discovery and development of drugs to treat DMD and other neuromuscular disorders. \n\nDissecting early nephron patterning and segmentation in kidney organoids derived from hPSCs\nZarina Nauryzgaliyeva \, Pluripotency for organ regeneration Group \nThe formation and maturation of organs during development is a complex\, yet beautifully orchestrated process. Embryonic cells have a unique capacity to self-organize within the forming tissue\, where morphogenetic movements have been shown to facilitate tissue organization and subsequent organ formation. In kidney organogenesis\, the mature organ arises from crucial reciprocal interactions between the ureteric bud (UB) and metanephric mesenchyme (MM)\, which give rise to the collecting duct and nephron\, respectively. The development of mature nephrons during kidney organogenesis is a dynamic process so far studied taking advantage of in vivo models. Accumalative findings in mice have shown that the MM undergoes mesenchymal to epithelial transition (MET)\, giving rise to epithelial renal vesicles (RVs) that further undergo structural changes and shift towards comma shaped and s-shaped bodies (CSBs/SSBs)\, which eventually develop into nephron like structures. Those studies have helped identify Wnt/b-catenin and Notch signalling pathways as key players in nephron patterning and segmentation (proximal\, medial\, distal segments).\nAt the same time\, tissue morphogenesis is largely a biomechanical process\, resulting from constant movements of cells\, changes in forms of developing segments and forces generated therein. The biomechanical dynamics occurring during RV emergence and further nephron patterning are yet to be explored in the human context in real time. If these biomechanical processes are interconnected with mechanical signals remains an open question in the field. The answer to these questions may have an important impact for understanding nephron formation\, and conversely\, disease-related phenotypes due to mutations in genes orchestrating RV patterning and segmentation as occurs in congenital defects of the kidney and the urinary tract (CAKUT disease).\nHere\, we aim to use human pluripotent stem cell (hPSCs) derived kidney organoids to gain fundamental understanding of early nephron patterning and segmentation by mapping force transmission between cells and their extracellular matrix (ECM) and evaluating their co-evolution during renal fate specification and differentiation.\nhPSCs are guided towards the renal fate on compliant PDMS hydrogels with controlled rigidities (mimicking embryonic microenvironment) in a 2D culture system. PDMS hydrogels between 3 kPa (soft) and 18 kPa (rigid) are generated by adapting the compositional ratio of PDMS components and are further functionalized and decorated with fibronectin. Using this system\, we have started to spatiotemporally characterise early steps of nephrogenesis by immunofluorescence and confocal analysis\, time-lapse imaging\, and traction force microscopy (TFM). These analyses are nowadays conducted during RV emergence prior proximal-distal RV polarization and formation of the nephron-like segments.\nThe current techniques will permit quantitative and qualitative observations of multicellular behaviours at key stages of 2D renal differentiation. Furthermore\, this system will allow us to spatiotemporally map cell-cell and cell-ECM forces and evaluate their evolution throughout renal fate specification with the final aim to decouple mechano-related processes sustaining nephron formation from classical biochemical signalling. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am. \n  \nWith the support of Joan Oró grant to hire research staff in training (FI 2025)\, 2023 FI-2 00386\, funded by Generalitat de Catalunya and by the European Social Fund Plus. \n \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-ainoa-tejedera-and-zarina-nauryzgaliyeva/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230426T110000
DTEND;TZID=Europe/Madrid:20230426T110000
DTSTAMP:20260403T213252
CREATED:20230412T131424Z
LAST-MODIFIED:20230412T131618Z
UID:107088-1682506800-1682506800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Ubaka Ogbogu
DESCRIPTION:Foregrounding justice\, equity and inclusion as determinants of access to precision medicine: an ethical case study of patient-derived tissue organoids.\nDr. Ubaka Ogbogu\, Professor and the Associate Dean Research in the Faculty of Law from the University of Alberta\, Canada.  \nUbaka Ogbogu is a Professor and the Associate Dean Research in the Faculty of Law. He is also the Chair of the University of Alberta Research Ethics Board 2 and the Katz Research Fellow in Health Law and Science Policy. Dr. Ogbogu is a recipient of the Confederation of Alberta Faculty Associations Distinguished Academic Early Career Award. He holds a doctorate in law from the University of Toronto\, a Master of Laws degree from the University of Alberta and undergraduate degrees in law from the University of Benin\, Nigeria and the Nigerian Law School. \nOgbogu’s scholarly work is focused broadly on the ethical\, legal and societal implications of novel and emerging biotechnologies and associated research. His publications have explored a diverse range of issues in this field\, including the ethical and legal issues associated with stem cell research\, gene and engineered cell therapies\, biobanks\, germline gene editing. In his talk\, Prof. Obgobu will reflect about these issues and also discuss how foregrounding justice\, equity and inclusion are elements that impact on access to precise medicine. \nHe has been invited to IBEC by Nuria Montserrat. \n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ubaka-ogbogu/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230421T093000
DTEND;TZID=Europe/Madrid:20230421T140000
DTSTAMP:20260403T213252
CREATED:20230309T170353Z
LAST-MODIFIED:20230309T170353Z
UID:105706-1682069400-1682085600@ibecbarcelona.eu
SUMMARY:Course · Inclusive Science; attention to diversity in science education projects
DESCRIPTION:This course aims to promote inclusive education in scientific education activities in non-formal settings\, guaranteeing access to scientific culture for all children and adolescents\, regardless of their learning needs. \nDuring the course\, general guidelines and guidelines will be presented to accompany students with visual disabilities\, as well as practical examples of STEAM activities. Accessibility and digital usability will also be addressed and tools will be offered to contribute to access to information for students with visual disabilities. \nThis course is organized by the Bioengineering Institute of Catalonia (IBEC) in collaboration with ONCE. \n  \nRegistration is required here.
URL:https://ibecbarcelona.eu/event/course-%c2%b7-inclusive-science-attention-to-diversity-in-science-education-projects/
LOCATION:Centro de Recursos Educativos ONCE Barcelona\, Gran Vía de les Corts Catalanes\, 394\, Barcelona.
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230413T150000
DTEND;TZID=Europe/Madrid:20230413T170000
DTSTAMP:20260403T213252
CREATED:20230328T155642Z
LAST-MODIFIED:20230328T155642Z
UID:106462-1681398000-1681405200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:Engineering the cancer: from biomaterials to on-chip solutions\nDavid Caballero; Research Institute on Biomaterials\, Biodegradables and Biomimetics\, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine\, University of Minho\, Portugal. \nCancer is a complex and multifaceted pathology\, which is influenced by numerous factors\, including the tumor microenvironment (TME). This environment is composed of various of components that interact in a tightly regulated manner\, affecting cancer cell behavior and response to treatment. Building realistic models of the TME is therefore essential for improving our knowledge of cancer pathophysiology and developing more effective therapies. In recent years\, there has been growing interest in using precisely-engineered biomaterials and microphysiological systems to create accurate 3D in vitro models of the TME. These models can provide a more physiologically-relevant habitat for studying fundamental aspects of cancer biology and for performing drug screening. Additionally\, when combined with organ-on-a-chip technology\, these models offer a high degree of biomimicry and control\, allowing for a precise recreation and better understanding of key biological functions of the native TME\, surpassing what traditional platforms can achieve. In this lecture\, I will present our latest works utilizing biomimetic materials and on-chip systems as powerful preclinical tools for engineering realistic in vitro models of the TME to study key aspects of tumorigenesis\, for drug screening/discovery purposes\, and for disease diagnosis applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-caballero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230331T100000
DTEND;TZID=Europe/Madrid:20230331T110000
DTSTAMP:20260403T213252
CREATED:20230322T104147Z
LAST-MODIFIED:20230322T111957Z
UID:106348-1680256800-1680260400@ibecbarcelona.eu
SUMMARY:PhD Discussions: José Muñoz-López
DESCRIPTION:Design and characterization of bifunctional hydrophilic Janus micelles\nJosé Muñoz-López\, Molecular Bionics Group \nJanus micelles are featured by their biphasic geometry of heterogeneous composition and distinctive properties in the core and corona. Such anisotropic design has attracted much attention from the scientific community due to the versatility of chemistries employed for generating Janus’ morphologies and their potential applications. In this work\, we present a novel ABC amphiphilic triblock copolymer system with the ability to form Janus micelles. The micelles are generated by solution-mediated self-assembly of the A and C hydrophilic\, and B hydrophobic blocks. Subsequently\, the hydrophilic blocks in the proposed triblock system will be functionalized with different and specific bioactive ligands to enable the constitution of multifunctional supramolecular scaffolds. The final aim of the project herein presented is to develop nanodrugs with well-defined dissimilar phenotypical domains\, in the same fashion as the asymmetric functionalisation of antibodies that already exist in nature\, to perform alike. To this end\, poly(ethylene glycol)-polylactide-poly(N-vinylpyrrolidone) PEG-PLA-PVP triblock copolymer was synthesised in two steps: first\, poly(ethylene glycol)-polylactide-2-bromo-2-methylpropanoate (PEG-PLA-Br) diblock macroinitiator was synthesized by the ring-opening polymerization of DL-lactide with commercial poly(ethylene glycol) and quenched with 2-bromo-isobutiryl-bromide. After that triblock copolymer was synthesized by the atom transfer radical polymerization (ATRP) of N-vinylpyrrolidone monomer (NVP) initiated by the PEG-PLA-Br diblock produced in the former synthetic step. The characterization of the produced diblock and triblock copolymers were carried out by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). Such techniques enabled us to verify the controlled radical polymerization of NVP and the complete conversion of PEG-PLA-Br diblock to the proposed PEG-PLA-PVP triblock. The morphologies adopted by PEG-PLA-Br and PEG-PLA-PVP in solution were investigated by transmission electron microscopy (TEM)\, confirming the formation of micelles for both block copolymers. TEM images showed differences in the negative stained micelles generated in the diblock and triblock copolymers systems. Such differences indicate the asymmetric distribution of both hydrophilic blocks\, PEG and PVP\, in the self-assembling of the PEG-PLA-PVP triblock system. Further structure characterizations will include atomic force microscopy (AFM)\, cryo-TEM\, electron energy loss spectroscopy (EELS)\, and ultimately the functionalization of both coronas with different targeting ligands. \n\n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-jose-munoz-lopez/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230320T090000
DTEND;TZID=Europe/Madrid:20230321T130000
DTSTAMP:20260403T213252
CREATED:20230309T155242Z
LAST-MODIFIED:20230309T155242Z
UID:105696-1679302800-1679403600@ibecbarcelona.eu
SUMMARY:Barcelona Integrative Resonance Symposium
DESCRIPTION:Barcelona Integrative Resonance\nThe symposium aims to celebrate the strong magnetic resonance momentum in Barcelona and bring together the community working with this highly versatile technique in a plethora of different applications. Also\, it will represent the kick-off meeting upon the installation in Barcelona of three new magnetic resonance instruments: a GHz NMR\, a pulsed EPR-ENDOR\, and a MRI linked to hyperpolarization. \nThe NMR and EPR instruments will be part of the Scientific and Technological Centers of the University of Barcelona (CCiTUB). The Hyperpolarization-MRI instrument is part of the Institute for Bioengineering of Catalonia (IBEC) and is located next to the NMR instruments in the Barcelona Science Park. The 1 GHz NMR instrument is part of a Spanish Singular Scientific and Technological Infrastructure with nodes in Barcelona\, Bilbao and Madrid. \nThe new infrastructures witness the vitality of the magnetic resonance community. We want to emphasize by this joint celebration the importance of strengthening the connection between the diverse flavors of magnetic resonance\, as well as the different scientific fields and institutions. The list of speakers includes a nearly 50%-50% balance between consolidated scientific leaders and early career scientists that represent the bright future of magnetic resonance in Catalonia\, Spain and Europe.
URL:https://ibecbarcelona.eu/event/barcelona-integrative-resonance-symposium/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress,Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230310T090000
DTEND;TZID=Europe/Madrid:20230310T183000
DTSTAMP:20260403T213252
CREATED:20230223T124418Z
LAST-MODIFIED:20230223T124418Z
UID:104680-1678438800-1678473000@ibecbarcelona.eu
SUMMARY:2023 BIST Symposium on Microscopy\, Nanoscopy and Imaging Sciences
DESCRIPTION:The sixth edition of the BIST Symposium on Microscopy\, Nanoscopy and Imaging Sciences will take place on March 10\, 2023\, at Institute of Photonic Sciences (ICFO) \nThe event will include a series of talks and discussions featuring experts in various fields such as Optical Microscopy\, Electron Microscopy\, Scanning probe Microscopy\, Raman Imaging and Spectroscopy and Imaging Technology\, among others. \n  \nMore information here. \nRegister here. \n 
URL:https://ibecbarcelona.eu/event/2023-bist-symposium-on-microscopy-nanoscopy-and-imaging-sciences/
LOCATION:ICFO – Auditorium\, Mediterranean Technology Park\, Av. Carl Friedrich Gauss\, 3\,\, Castelldefels\, 08860
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230307T173000
DTEND;TZID=Europe/Madrid:20230307T190000
DTSTAMP:20260403T213252
CREATED:20230124T141825Z
LAST-MODIFIED:20230223T124550Z
UID:103698-1678210200-1678215600@ibecbarcelona.eu
SUMMARY:Inauguració exposició laboratori de paisatges humans
DESCRIPTION:El Laboratorio de Paisatges Humans i la recerca artística\n\n\n\n\n\n“Laboratori de Paisatges Humans” és el resultat del procés creatiu portat a terme perla il·lustradora Roser Cussó durant la seva estada artística a l’Institut de Bioenginyeria de Catalunya (IBEC). \nLa imaginació i la ficció\, com a eines d’investigació\, ens ajuden a construir espais ficticis per dibuixar el que és invisible. Aquesta exposició mostra com la investigació artística troba nous punts de partida sobre els quals construir noves narratives. \nAquest projecte s’ha portat a terme amb una beca per a la recerca i la innovació en els àmbits de les arts visuals\, de l’arquitectura i el disseny\, de les arts escèniques\, de la música i del pensament\, atorgada de la Generalitat de Catalunya. \nAquesta exposició estarà oberta al públic fins al 28 de febrer. \n\n\n\n\nActe inaugural:\nDimecres 7 de març a les 17:30h · Parc Científic de Barcelona · Carrer Baldiri Reixac\, 4-8\nRegistre aquí.
URL:https://ibecbarcelona.eu/event/inauguracio-exposicio-laboratori-de-paisatges-humans/
LOCATION:Cluster II
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230303T100000
DTEND;TZID=Europe/Madrid:20230303T120000
DTSTAMP:20260403T213252
CREATED:20230222T091933Z
LAST-MODIFIED:20230227T120702Z
UID:104641-1677837600-1677844800@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills Session: Life at IBEC: Opportunities for PhD students
DESCRIPTION:Are you doing your PhD at IBEC? Do you know what you need to apply for the PhD Certificate of excellence or award? Do you know there are many different committees that you can join? Have you heard about the mentoring and training sessions that you can join? What about other mobility programmes? Would you like to participate in science education or outreach activities\, and you do not know who to talk to? Do you have any idea of how to proceed when you publish your first paper? \nAll these questions and many others will be answered in our next Complementary Skills session.  Come and learn with IBEC’s research management team and the IBEC PhD committee all the opportunities for PhDs that we offer at IBEC. \n  \nCarolina Mari and Arnau Fornell\, HR Department \nMaria Arista\, Communications Department \nCristina Arimany and Fidel Bellmunt\, Strategic Initiatives Department \nMiquel Bosch\, PhD Committee
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-session-life-at-ibec-opportunities-for-phd-students/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230228T103000
DTEND;TZID=Europe/Madrid:20230228T123000
DTSTAMP:20260403T213252
CREATED:20230223T124019Z
LAST-MODIFIED:20230223T124142Z
UID:104674-1677580200-1677587400@ibecbarcelona.eu
SUMMARY:NANO RARE DISEASES DAY (Event in Spanish)
DESCRIPTION:El Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapias. \nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \n\n\n\n\n\n\n\n\n\n\nRegistro aquí.
URL:https://ibecbarcelona.eu/event/nano-rare-diseases-day-event-in-spanish/
LOCATION:Hospital Sant Joan de Déu\, Pg. de Sant Joan de Déu\, 2\, Esplugues de Llobregat
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230217T150000
DTEND;TZID=Europe/Madrid:20230217T170000
DTSTAMP:20260403T213252
CREATED:20230208T150410Z
LAST-MODIFIED:20230208T150410Z
UID:104133-1676646000-1676653200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Madhura Murar
DESCRIPTION:Peptide functionalized polymeric nanocarriers: Towards selective targeting of prostate cancer\n\n\n\n\nAuthor: Madhura Vijay Murar\, nanoscopy for nanomedicine\n\nThis thesis defence will take place at “Aula Magna” Faculty of Physics\,\n\nUniversity of Barcelona (Carrer de Martí i Franquès\, 1\, 11\, 08028 Barcelona) at 15:00 \n\nYou can join online to see the defense in the following link. \n\n\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-madhura-murar/
LOCATION:Aula Magna\, Faculty of Physics\, UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230217T100000
DTEND;TZID=Europe/Madrid:20230217T120000
DTSTAMP:20260403T213252
CREATED:20230202T144717Z
LAST-MODIFIED:20230202T144717Z
UID:103953-1676628000-1676635200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Presentation of the new Programme of ”la Caixa” Foundation on Innovation in Biomedicine and Health
DESCRIPTION:Alexandre Esteban\, Programme Manager at ”la Caixa” Foundation\nDuring the event\, all the details of the new Innovation programme will be presented\, with which the “la Caixa” Foundation reinforces its commitment to innovation and knowledge transfer in Spain and Portugal. \nThis new programme will fund breakthrough technologies with high market potential.
URL:https://ibecbarcelona.eu/event/ibec-seminar-presentation-of-the-new-programme-of-la-caixa-foundation-on-innovation-in-biomedicine-and-health/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230206T080000
DTEND;TZID=Europe/Madrid:20230207T170000
DTSTAMP:20260403T213252
CREATED:20221202T105931Z
LAST-MODIFIED:20221202T105931Z
UID:102311-1675670400-1675789200@ibecbarcelona.eu
SUMMARY:Transdisciplinary Approaches for Neuroblastoma therapy symposium
DESCRIPTION:This networking event brings together experts from different fields but with the same objective- to join forces to fight NB and accelerate new treatments discovery. To this end\, the main aim of the networking event is to share knowledge on Neuroblastoma between physicians\, researchers\, and members of patient advocacy organizations\, and build up a research consortium to actively participate in the Europe’s Beating Cancer Plan. \nThe symposium will be held at the Sant Joan de Deu Hospital in the greater Barcelona area (Spain); it will be carried out in four sessions to discuss new advancements in Neuroblastoma characterization and modeling\, cutting-edge technologies\, and current strategies for Neurblastoma therapy. \nThe network event will serve to bring knowledge for all participants\, build up new research networks\, and disseminate the event conclusions to the general public\, thanks to the support of the Association of Families and Friends of Children with Neuroblastoma (NEN). \nThe symposium encourages the participation of Early Career Researchers and enables involvement in the network of usually underrepresented countries in Europe. \nProgramme and registration here.
URL:https://ibecbarcelona.eu/event/transdisciplinary-approaches-for-neuroblastoma-therapy-symposium/
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230203T100000
DTEND;TZID=Europe/Madrid:20230203T130000
DTSTAMP:20260403T213252
CREATED:20230126T085229Z
LAST-MODIFIED:20230126T085229Z
UID:103689-1675418400-1675429200@ibecbarcelona.eu
SUMMARY:PhD Discussions: Gerardo Ceada Torres
DESCRIPTION:Role of Eph/Ephrin in the Compartmentalization of the Intestinal Stem Cell Niche\nGerardo Ceada Torres\, Integrative cell and tissue dynamics Group \nThe intestinal epithelium is a monolayer of cells that covers the inner surface of the gut. It protects against pathogens\, absorbs nutrients\, and secretes hormones and other molecules. This monolayer is folded into finger-like protrusions composed of differentiated cells\, called villi\, and invaginations\, called crypts\, where stem cells reside. Essential features of the intestinal epithelium such as folding of the crypt\, spatial distribution of different cell types\, and cellular movements from crypt to villus-like domains can be recapitulated in vitro in intestinal organoids. Direct force measurements in mouse intestinal organoids grown on soft hydrogels show that tightly regulated cell-ECM and cell-cell forces compartmentalizes the tissue into crypts- and villus-like domains. A dynamic mechanical boundary composed of basally constricted cells is established between the stem cell niche and differentiated cells of the villus-like region. The Eph/Ephrin signaling pathway has been proposed as a key regulator of compartmentalization and cell positioning in the intestinal epithelium. Whether and how Eph/Ephrin signaling governs the mechanical phenotype observed at the crypt-villus boundary remains\, however\, an open question. We are currently addressing this question by genetically perturbing Eph/Ephrin signaling in intestinal organoids. Preliminary data show that EphB2/3 KO organoids display defects in cell positioning\, reduced basal constriction at the crypt-villus boundary and aberrant size of the proliferative and differentiated compartments. \n\n  \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-gerardo-ceada-torres/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230124T110000
DTEND;TZID=Europe/Madrid:20230124T130000
DTSTAMP:20260403T213252
CREATED:20230102T141828Z
LAST-MODIFIED:20230102T141828Z
UID:103359-1674558000-1674565200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xavier Arqué
DESCRIPTION:Unraveling the Fundamental Aspects of Enzyme-powered Micromotors\n\n\n\n\nAuthor: Xavier Arqué\, Smart Nano-Bio-Devices Lab\n\nThis thesis defence will take place at “Aula Magna” Building A\, Faculty of Pharmacy\,\nUniversity of Barcelona (Campus Diagonal\, Av. de Joan XXIII\, 27-31\, 08028 Barcelona) at 11:00\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xavier-arque/
LOCATION:Aula Magna\, Faculty of Pharmacy\, Av. Joan XXIII s/n\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230120T100000
DTEND;TZID=Europe/Madrid:20230120T120000
DTSTAMP:20260403T213252
CREATED:20230109T095712Z
LAST-MODIFIED:20230109T095712Z
UID:103484-1674208800-1674216000@ibecbarcelona.eu
SUMMARY:IBEC Seminar (online): Sam Hall
DESCRIPTION:Presentation of Open Research Europe publishing plataform\nSam Hall\, from Open Research Euorpe \nOpen Research Europe is the European Commission’s open access publishing platform for research stemming from Horizon 2020 and Horizon Europe funding. In this webinar Senior Content Acquisition Editor Sam Hall will show how the platform enables the rapid dissemination of results and facilitates open and constructive research discussion\, and maximizes the discoverability and credit for researchers and their work. Sam will also explain the funder-pays model which means that all publication fees are met by the European Commission at no cost to the researcher or the project. \n\nSam Hall is a Senior Content Acquisition Editor for F1000\, commissioning articles and Collections for Open Research Europe. Launched in March 2021\, Open Research Europe is an open access publishing Platform for research stemming from Horizon 2020\, Horizon Europe and/or Euratom funding across all subject areas. Within this broad remit\, Sam focusses on the research area of Engineering and Technology\, and most recently the Data Note article type. Sam has almost 10 years of experience working in publishing\, and in this time has worked in contrasting companies and settings. This has included society publishers\, start-ups\, and international governmental organizations. \nLink Teams here
URL:https://ibecbarcelona.eu/event/ibec-seminar-online-sam-hall/
LOCATION:Online
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230119T093000
DTEND;TZID=Europe/Madrid:20230119T113000
DTSTAMP:20260403T213252
CREATED:20230112T111707Z
LAST-MODIFIED:20230112T111707Z
UID:103539-1674120600-1674127800@ibecbarcelona.eu
SUMMARY:IRB Research Node/IBEC Joint Seminar: Nunilo Cremades
DESCRIPTION:Date: Thursday 19 January 2023\, 9:30h\nPlace: Felix Serratosa Hall\, PCB \nSpeaker: Nunilo Cremades\, PhD – Associate Professor at Dept. Biochemistry and Molecular and Cellular Biology and Group Leader at Institute for Biocomputation and Physics of Complex Systems (BIFI)\, University of Zaragoza\, Spain \nTitle:  Liquid-liquid phase separation and co-aggregation of neurodegenerative disease-related alpha-synuclein and Tau proteins \nHost: Xavier Salvatella (IRB) & Benedetta Bolognesi (IBEC) \nAbstract: \nSpatial segregation in the cell can be achieved through the formation of protein-rich liquid-like dense bodies\, termed biomolecular condensates or liquid droplets\, through a process known as liquid-liquid phase separation (LLPS). Emerging evidence supports the hypothesis that aberrant protein-driven LLPS and the transition of the liquid droplets to solid-like structures might be a relevant cellular pathway leading to the formation of amyloid\, toxic aggregates that are often a hallmark of relevant neurodegenerative diseases. A number of experimental studies have highlighted the flexible\, typically disordered and ‘multivalent’ nature of the constituent proteins in these liquid-like condensates\, although less is known about the particular molecular determinants governing the growth and maturation of these condensates into more solid-like states. While the LLPS process of Tau\, the protein that is generally associated with Alzheimer´s disease\, has been recently clarified\, that of alpha-synuclein (αS)\, the protein linked to Parkinson´s disease\, remains obscure. In this talk\, I will show our recent findings that demonstrate that αS actively phase-separates into liquid condensates by electrostatic complex coacervation with positively charged polypeptides such as Tau. By combining a set of advanced biophysical techniques\, we have been able to characterize αS/Tau LLPS and identified key factors leading to the co-aggregation of both proteins inside the coacervates. The mechanism of co-aggregation between αS and Tau that we have identified could be the basis for the in vivo formation of αS/Tau hetero-aggregates observed in the brains of patients suffering from synucleinopathies.
URL:https://ibecbarcelona.eu/event/irb-research-node-ibec-joint-seminar-nunilo-cremades/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230118T120000
DTEND;TZID=Europe/Madrid:20230118T140000
DTSTAMP:20260403T213252
CREATED:20230112T111150Z
LAST-MODIFIED:20230112T111309Z
UID:103534-1674043200-1674050400@ibecbarcelona.eu
SUMMARY:IRB Research Node/IBEC Joint Seminar:  Jolanda van Leeuwen
DESCRIPTION:Date: Wednesday 18 January 2023\, 12:00h\nPlace: Audiorium Room\, PCB \nSpeaker: Jolanda van Leeuwen\, University of Lausanne\, Lausanne\, Switzerland \nTitle:  Systematic analysis of genetic suppression interactions \nHost: Patrick Aloy (IRB) & Benedetta Bolognesi (IBEC) \nAbstract: \nRecent genome sequencing efforts have identified people that are healthy despite carrying mutations that have been directly associated with severe early-onset Mendelian diseases. These resilient individuals may carry secondary mutations elsewhere in the genome that can compensate for the deleterious effect of the disease-associated mutation\, a phenomenon referred to as genetic suppression. Identification of the protective mutations could highlight strategies for therapeutic intervention\, but we currently lack the expertise to identify the suppressor mutations among the millions of variants scattered across the genomes of resilient individuals. \nI will discuss how we use systematic genetic suppression interaction screens in the budding yeast and cultured human cells to dissect gene function and pathway connectivity\, and to define conserved properties of genetic suppression that we can use to predict suppression interactions between genomic variants across species.
URL:https://ibecbarcelona.eu/event/irb-research-node-ibec-joint-seminar-systematic-analysis-of-genetic-suppression-interactions/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230112T150000
DTEND;TZID=Europe/Madrid:20230112T170000
DTSTAMP:20260403T213252
CREATED:20230109T120957Z
LAST-MODIFIED:20230109T120957Z
UID:103511-1673535600-1673542800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Granero Moya
DESCRIPTION:STUDY OF THE EFFECTS OF MECHANICAL FORCE ON NUCLEO-CYTOPLASMIC TRANSPORT\n\n\n\n\nAuthor: Ignasi Granero Moya\, Cellular and molecular mechanobiology\n\n\nThis thesis defence will take place at “Facultat de Medicina de la UB (Hospital Clínc)” at 15:00. Room to be determined.\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ignasi-granero-moya/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230111T120000
DTEND;TZID=Europe/Madrid:20230111T130000
DTSTAMP:20260403T213252
CREATED:20230109T085957Z
LAST-MODIFIED:20230109T102957Z
UID:103479-1673438400-1673442000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Manuel Valero
DESCRIPTION:The role of inhibition in hippocampal coding\nManuel Valero\, PhD NYU Neuroscience Institute\, New York University (US) \nThe fundamental computation a single neuron performs is to integrate incoming excitatory and inhibitory inputs to decide whether to fire an action potential and feedback its activity into the network. Investigation of this synaptic computation requires access to the neuron subthreshold dynamics\, whose state-of-art methodologies have remained unaltered for decades and are unrealistic for cell assemblies and behaving animals.\nInstead of intracellular recording\, we propose a method to optogenetically probe the membrane polarization of the cells with short depolarizing pulses using chronically implanted µLED probes (4 shanks with 3 µLED/shank). Light-sensitive neurons responded to one or more µLEDs and the spike numbers were used as a proxy for estimating relative changes in the membrane potential dynamics. Strikingly\, induced spike responses gain sharply increased several-folds inside the preferred position (place fields) of the responsive cells. These results are compatible with a tuning curve model in the CA1 pyramidal cells where excitation and inhibition display a concerted and reciprocal relationship. When optogenetic stimulation was probed on non-place cells\, majority of the putative non-place cells showed place-related activity. Finally\, we optically probed neurons around sharp wave-ripples (SPW-Rs)\, hippocampal events considered a key mechanism for memory consolidation and action planning. In the short time window of SPW-R\, excitatory and inhibitory neurons increased in parallel. As expected\, optogenetic probing of the CA1 networks showed that\, in contrast to the large gain within place fields\, responsivity of pyramidal cells showed a robust decrease during SPW-Rs.\nWe have developed a method for studying the subthreshold dynamics of individual cells in chronic recordings using novel high-resolution optical stimulation as a proxy for membrane polarization. These experiments disclosed a reciprocal interaction between inhibition and excitation along the place fields of CA1 and demonstrated that the same exact perturbation can bring about opposite responses during exploration and transient SPW-Rs. \n\n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-manuel-valero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221221T113000
DTEND;TZID=Europe/Madrid:20221221T133000
DTSTAMP:20260403T213252
CREATED:20221214T140135Z
LAST-MODIFIED:20221214T140135Z
UID:102662-1671622200-1671629400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Xavier Rovira-Clavé
DESCRIPTION:Epitope barcoding and subcellular high-plex imaging reveal clonal tumor patch behaviors\nXavier Rovira-Clavé\, PhD \nIntratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response to treatment. Current technologies are still largely unsuitable to accurately track phenotypes and clonal evolution within tumors\, especially in response to genetic manipulations. In this seminar I will present our recent development of epitopes for imaging using combinatorial tagging (EpicTags)\, which we coupled to multiplexed ion beam imaging (EpicMIBI)\, for in situ tracking of barcodes within tissue microenvironments. Using EpicMIBI\, we dissected the spatial component of cell lineages and phenotypes in xenograft models of small-cell lung cancer. We observed emergent properties from mixed clones leading to the preferential expansion of clonal patches for both neuroendocrine and non-neuroendocrine cancer cell states in these models. In a tumor model harboring a fraction of PTEN-deficient cancer cells\, we observed a non-autonomous increase of clonal patch size in PTEN wild-type cancer cells. Thus\, EpicMIBI facilitates in situ interrogation of cell-intrinsic and cell-extrinsic processes involved in intratumoral heterogeneity and it is posed to help reveal principles and mechanisms of tissue developmental processes\, in both normal and malignant growth\, that will thus accelerate therapeutic discoveries. \n\nDr. Xavier Rovira-Clavé is an instructor in the laboratory of Professor Garry Nolan in the Department of Microbiology and Immunology at Stanford University\, where he develops and applies multiparameter technologies to study tissue biology in models of cancer and infectious diseases. In 2016\, he received his PhD in Immunology from the University of Barcelona under the supervision of Dr. Enric Espel and Dr. Manuel Reina. He also trained for a year in cancer biology studies as a visiting PhD student in the group of Dr. Gregory Emery at the University of Montreal. He has published 12 articles\, including some in leading journals such as Cancer Cell and Immunity. He holds 3 granted patents. He has received 5 competitive fellowships\, including the prestigious LLS Career Development Award and the EMBO postdoctoral fellowship. His areas of research include cancer\, the immune system\, and infectious diseases. His technical expertise includes highly multiplexed tissue imaging (spatial proteomics)\, single-cell assays\, molecular biology approaches\, cell culture\, in vitro co-culture systems\, engineered tumors\, murine models\, genome editing\, bioconjugation strategies\, assay automation\, and single-cell spatial data analysis. His recent research efforts have been focused in the development of imaging technologies to subcellularly locate structurally unmodified drugs at the nanometer scale\, track subclonal growth in situ\, and co-detect multiple biomolecular species (RNA\, DNA\, and protein) to enable new understanding of spatial structures at the molecular\, cellular and tissue levels with the long-term goal to improve disease management. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-xavier-rovira-clave/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221212T110000
DTEND;TZID=Europe/Madrid:20221212T130000
DTSTAMP:20260403T213253
CREATED:20221130T104006Z
LAST-MODIFIED:20221130T104100Z
UID:102248-1670842800-1670850000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Adrián López Canosa
DESCRIPTION:Microphysiological Systems for the Evaluation of Biomaterials in Regenerative Therapies\n\n\n\n\nAuthor: Adrián López Canosa\, Biomaterials for Regenerative Therapies\n\n\nThis thesis defence will take place at “Sala de Graus Eduard Fontseré” at 11:00h.\n\nInformation
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maximilian-loeck-2/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221202T100000
DTEND;TZID=Europe/Madrid:20221202T140000
DTSTAMP:20260403T213253
CREATED:20221124T124127Z
LAST-MODIFIED:20221124T124856Z
UID:102173-1669975200-1669989600@ibecbarcelona.eu
SUMMARY:Sostenibilidad en el PCB (spanish)
DESCRIPTION:En este seminario\, Glòria Pladellorens\, jefa de Calidad\, Seguridad y Medio Ambiente del PCB\, nos explicará todas las acciones que se están llevando a cabo desde PCB para avanzar hacia un parque científico más sostenible. \nEl comité de sostenibilidad ha invitado a Glòria a dar esta charla que será una muy buena oportunidad para resolver todas esas dudas que nos planteamos y compartir nuestras inquietudes e ideas para tener un entorno de trabajo más sostenible. \n  \nThis seminar will be in Spanish\, a translated report will be prepared and distributed among the non-Spanish speakers. \nAll members of research groups in the process of My green lab certification are strongly encouraged to attend.
URL:https://ibecbarcelona.eu/event/sostenibilidad-en-el-pcb-spanish/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221125T100000
DTEND;TZID=Europe/Madrid:20221125T120000
DTSTAMP:20260403T213253
CREATED:20221116T090407Z
LAST-MODIFIED:20221116T090407Z
UID:101122-1669370400-1669377600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Maria Gallo and Nimesh Chahare
DESCRIPTION:Generation Of Reporter Human Pluripotent Stem Cell Lines To Study Cardiac Development And Disease\nMaria Gallo\, Pluripotency for organ regeneration Group \nThe development and the use of human pluripotent stem cells (hPSCs) represent an effective tool to recapitulate characteristics related to tissue differentiation\, morphogenesis and conversely\, human diseases. Through their inherent capacity to differentiate towards the three germ layers and their easy manipulation\, it has been possible to generate three dimensional (3D) self-organized organ-like structures\, the so-called organoids. In this context\, the advent of CRISPR-Cas9 technology has now allow to incorporate permanent or transient changes in the genome of living organisms and cells. Our laboratory has developed a cellular platform\, named iCRISPR2 (iC2)\, that allows to perform highly efficient genome editing in hPSCs through the insertion of an inducible Cas9 under the endogenous TET/ON promoter. This platform allowed us the generation of reporter\, knock-out and knock-in hPSCs lines. By exploiting the generation of cardiac reporter cell lines it has been possible to define new approaches for the generation of self-assembled cardiac-like organoids. Cardioids have been characterized at conventional molecular biology techniques\, confocal microscopy and functional analysis. Moreover\, taking advantages of specific cell culture conditions emulating early stages of diabetic cardiomyopathy it has been possible to establish a platform for the interrogation of transcriptional and functional changes during diabetic disease. \n\nMechanics of epithelial layers subjected to controlled pressure\nNimesh Chahare\, Integrative cell and tissue dynamics Group \nEpithelial sheets form specialized 3D structures suited to their physiological roles\, such as branched alveoli in the lungs\, tubes in the kidney\, and villi in the intestine. To generate and maintain these structures\, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses\, viscoelasticity\, and luminal pressure remains poorly understood. To address this question\, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup\, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure\, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach\, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However\, under sudden pressure reductions\, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-maria-gallo-and-nimesh-chahare/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221121T183000
DTEND;TZID=Europe/Madrid:20221121T193000
DTSTAMP:20260403T213253
CREATED:20221117T152328Z
LAST-MODIFIED:20221117T152546Z
UID:101231-1669055400-1669059000@ibecbarcelona.eu
SUMMARY:L’estat de la Ciència a Catalunya
DESCRIPTION:La investigació científica i tecnològica ha estat una de les claus del progrés de la societat de forma exponencial en els darrers anys. Aquesta investigació\, però\, només es pot portar a terme quan es té un ecosistema ric que permet als investigadors començar la seva tasca i desenvolupar-se. Quina és la situació actual a Catalunya? Quin és el marc català i quina és la perspectiva de futur? En parlem en aquesta sessió.\nA càrrec de Josep Samitier Martí\, director de l’Institut de Bioenginyeria de Catalunya (IBEC) i president de l’Associació Catalana d’Entitats de Recerca (ACER)\nPresenta l’acte: Aleix Ràmia\, ponent de la Secció. \n 
URL:https://ibecbarcelona.eu/event/101231/
LOCATION:Ateneu Barcelonès\, Canuda 6\, Barcelona\, 08002
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221118T090000
DTEND;TZID=Europe/Madrid:20221118T163000
DTSTAMP:20260403T213253
CREATED:20221028T104336Z
LAST-MODIFIED:20221028T104336Z
UID:99987-1668762000-1668789000@ibecbarcelona.eu
SUMMARY:Phys2BioMed Symposium
DESCRIPTION:Phys2BioMed Symposium\nPresent and future of mechanics of cells and tissues in health and disease\nThe mechanical properties of biological samples may provide insights into many physiological and pathological processes. Examples are the mechanical properties of cancer cells or changes of mechanical properties during cell invasion. Defining standardized procedures for nanomechanical measurements and providing\, in the longer-term\, a data bank of mechanical fingerprints of diseases\, can lead to the development of effective early-diagnostic tools. \nPhys2BioMed is an ITN (Innovative Training Network) that has the purpose of providing scientific and technological outcomes on biomechanics and mechanical determinants of diseases. The key advantage is merging diverse competences at the European level\, from different fields like nanoscience and nanotechnology\, physics\, biology\, and medicine. Thanks to the participation of hospitals and companies\, ESRs (Early Stage Researchers) are exposed also to the non-academic sector. \nThe scientific community is invited to participate in person or online in this symposium. \nCheck for the programme and register here.
URL:https://ibecbarcelona.eu/event/phys2biomed-symposium/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221111T100000
DTEND;TZID=Europe/Madrid:20221111T120000
DTSTAMP:20260403T213253
CREATED:20221104T105722Z
LAST-MODIFIED:20221104T105722Z
UID:100305-1668160800-1668168000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Astrid Viciano
DESCRIPTION:Is the price of pharmaceutical drugs justified?\nAstrid Viciano\, IBEC \n10 euros\, 1000 euros\, or rather 1 million? Many new medicines that have recently reached the market are prohibitively expensive. But are these prices justified? Science reporter Astrid Viciano has investigated the high prices of innovative therapies. For these investigations\, she received a number of European journalism stipends. \nViciano will explain how the pharmaceutical industry calculates prices for new drugs\, and who currently determines the costs for new medications in different healthcare systems. Looking into different\, concrete examples such as the drug Zolgensma for the treatment of spinal muscular atrophy\, she will point out how drugs are currently developed and approved\, and how medications for orphan diseases are developed. Moreover\, looking into historic examples such as insulin\, she will look into why access to potentially life-saving drugs is still not guaranteed in all regions of the world\, an urgent problem the Covid-19 pandemic has highlighted in the past two years. \n\nDr. Astrid Viciano has been working as a science journalist for German national media such as Süddeutsche Zeitung\, Die Zeit\, Spiegel\, and GEO for more than 20 years. \nShe has worked in a variety of European cross-border teams\, focusing on in-depth investigative science reporting.  From 2012 to 2016\, she worked as a freelance reporter from Paris\, and from 2009 and 2011 in Los Angeles. She has published articles in German\, English\, Dutch and Spanish. Viciano has won several national and international journalism awards\, grants\, and fellowships. \nAstrid Viciano is a medical doctor with a doctorate in immunology and virology and also has an M.A. in Specialized Journalism (USC Annenberg ’11). Currently she is „journalist-in-residence“ at IBEC. She holds the Spanish and German nationalities.
URL:https://ibecbarcelona.eu/event/ibec-seminar-astrid-viciano/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221109T160000
DTEND;TZID=Europe/Madrid:20221109T180000
DTSTAMP:20260403T213253
CREATED:20221028T104835Z
LAST-MODIFIED:20221028T104906Z
UID:100158-1668009600-1668016800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Takashi Hiiragi
DESCRIPTION:Multicellular coordination in context\nTakashi Hiiragi\, Hubrecht Institute\, The Netherlands \nA defining feature of living systems is the capacity to break symmetry and generate well-defined forms and patterns through self-organisation. Our group aims to understand the design principle of multicellular living systems using early mouse embryos as a model system. We developed an experimental framework that integrates biology\, physics and mathematics\, to understand how molecular\, cellular and physical signals are dynamically coupled across the scales for self-organisation. I will discuss our ongoing work investigating the coordination of developmental programmes in space and time. \n\nTakashi Hiiragi is group leader at the Hubrecht Institute.  The Hiiragi group aims to understand what defines multi-cellular living systems. In particular\, the group studies the design principle of tissue self-organization\, using early mammalian embryos as a model system. To this end\, they developed an experimental framework that integrates biology\, physics and mathematics. Their recent studies led to a model in which feedback between cell fate\, polarity\, and cell and tissue mechanics underlies multi-cellular self-organization. The group adopts a wide variety of experimental strategies including embryology\, genetics\, advanced microscopy\, biophysics\, engineering and theoretical modelling\, in order to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-takashi-hiiragi/
LOCATION:Sala Baobab\, Tower I - 11th floor
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221102T153000
DTEND;TZID=Europe/Madrid:20221102T173000
DTSTAMP:20260403T213253
CREATED:20221025T111442Z
LAST-MODIFIED:20221031T092456Z
UID:100038-1667403000-1667410200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Felipe Galvez-Cancino (canceled)
DESCRIPTION:
URL:https://ibecbarcelona.eu/event/ibec-seminar-felipe-galvez-cancino/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
END:VCALENDAR