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DTSTART;TZID=Europe/Madrid:20230111T120000
DTEND;TZID=Europe/Madrid:20230111T130000
DTSTAMP:20260404T005804
CREATED:20230109T085957Z
LAST-MODIFIED:20230109T102957Z
UID:103479-1673438400-1673442000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Manuel Valero
DESCRIPTION:The role of inhibition in hippocampal coding\nManuel Valero\, PhD NYU Neuroscience Institute\, New York University (US) \nThe fundamental computation a single neuron performs is to integrate incoming excitatory and inhibitory inputs to decide whether to fire an action potential and feedback its activity into the network. Investigation of this synaptic computation requires access to the neuron subthreshold dynamics\, whose state-of-art methodologies have remained unaltered for decades and are unrealistic for cell assemblies and behaving animals.\nInstead of intracellular recording\, we propose a method to optogenetically probe the membrane polarization of the cells with short depolarizing pulses using chronically implanted µLED probes (4 shanks with 3 µLED/shank). Light-sensitive neurons responded to one or more µLEDs and the spike numbers were used as a proxy for estimating relative changes in the membrane potential dynamics. Strikingly\, induced spike responses gain sharply increased several-folds inside the preferred position (place fields) of the responsive cells. These results are compatible with a tuning curve model in the CA1 pyramidal cells where excitation and inhibition display a concerted and reciprocal relationship. When optogenetic stimulation was probed on non-place cells\, majority of the putative non-place cells showed place-related activity. Finally\, we optically probed neurons around sharp wave-ripples (SPW-Rs)\, hippocampal events considered a key mechanism for memory consolidation and action planning. In the short time window of SPW-R\, excitatory and inhibitory neurons increased in parallel. As expected\, optogenetic probing of the CA1 networks showed that\, in contrast to the large gain within place fields\, responsivity of pyramidal cells showed a robust decrease during SPW-Rs.\nWe have developed a method for studying the subthreshold dynamics of individual cells in chronic recordings using novel high-resolution optical stimulation as a proxy for membrane polarization. These experiments disclosed a reciprocal interaction between inhibition and excitation along the place fields of CA1 and demonstrated that the same exact perturbation can bring about opposite responses during exploration and transient SPW-Rs. \n\n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-manuel-valero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221221T113000
DTEND;TZID=Europe/Madrid:20221221T133000
DTSTAMP:20260404T005804
CREATED:20221214T140135Z
LAST-MODIFIED:20221214T140135Z
UID:102662-1671622200-1671629400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Xavier Rovira-Clavé
DESCRIPTION:Epitope barcoding and subcellular high-plex imaging reveal clonal tumor patch behaviors\nXavier Rovira-Clavé\, PhD \nIntratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response to treatment. Current technologies are still largely unsuitable to accurately track phenotypes and clonal evolution within tumors\, especially in response to genetic manipulations. In this seminar I will present our recent development of epitopes for imaging using combinatorial tagging (EpicTags)\, which we coupled to multiplexed ion beam imaging (EpicMIBI)\, for in situ tracking of barcodes within tissue microenvironments. Using EpicMIBI\, we dissected the spatial component of cell lineages and phenotypes in xenograft models of small-cell lung cancer. We observed emergent properties from mixed clones leading to the preferential expansion of clonal patches for both neuroendocrine and non-neuroendocrine cancer cell states in these models. In a tumor model harboring a fraction of PTEN-deficient cancer cells\, we observed a non-autonomous increase of clonal patch size in PTEN wild-type cancer cells. Thus\, EpicMIBI facilitates in situ interrogation of cell-intrinsic and cell-extrinsic processes involved in intratumoral heterogeneity and it is posed to help reveal principles and mechanisms of tissue developmental processes\, in both normal and malignant growth\, that will thus accelerate therapeutic discoveries. \n\nDr. Xavier Rovira-Clavé is an instructor in the laboratory of Professor Garry Nolan in the Department of Microbiology and Immunology at Stanford University\, where he develops and applies multiparameter technologies to study tissue biology in models of cancer and infectious diseases. In 2016\, he received his PhD in Immunology from the University of Barcelona under the supervision of Dr. Enric Espel and Dr. Manuel Reina. He also trained for a year in cancer biology studies as a visiting PhD student in the group of Dr. Gregory Emery at the University of Montreal. He has published 12 articles\, including some in leading journals such as Cancer Cell and Immunity. He holds 3 granted patents. He has received 5 competitive fellowships\, including the prestigious LLS Career Development Award and the EMBO postdoctoral fellowship. His areas of research include cancer\, the immune system\, and infectious diseases. His technical expertise includes highly multiplexed tissue imaging (spatial proteomics)\, single-cell assays\, molecular biology approaches\, cell culture\, in vitro co-culture systems\, engineered tumors\, murine models\, genome editing\, bioconjugation strategies\, assay automation\, and single-cell spatial data analysis. His recent research efforts have been focused in the development of imaging technologies to subcellularly locate structurally unmodified drugs at the nanometer scale\, track subclonal growth in situ\, and co-detect multiple biomolecular species (RNA\, DNA\, and protein) to enable new understanding of spatial structures at the molecular\, cellular and tissue levels with the long-term goal to improve disease management. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-xavier-rovira-clave/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221212T110000
DTEND;TZID=Europe/Madrid:20221212T130000
DTSTAMP:20260404T005804
CREATED:20221130T104006Z
LAST-MODIFIED:20221130T104100Z
UID:102248-1670842800-1670850000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Adrián López Canosa
DESCRIPTION:Microphysiological Systems for the Evaluation of Biomaterials in Regenerative Therapies\n\n\n\n\nAuthor: Adrián López Canosa\, Biomaterials for Regenerative Therapies\n\n\nThis thesis defence will take place at “Sala de Graus Eduard Fontseré” at 11:00h.\n\nInformation
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maximilian-loeck-2/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221202T100000
DTEND;TZID=Europe/Madrid:20221202T140000
DTSTAMP:20260404T005804
CREATED:20221124T124127Z
LAST-MODIFIED:20221124T124856Z
UID:102173-1669975200-1669989600@ibecbarcelona.eu
SUMMARY:Sostenibilidad en el PCB (spanish)
DESCRIPTION:En este seminario\, Glòria Pladellorens\, jefa de Calidad\, Seguridad y Medio Ambiente del PCB\, nos explicará todas las acciones que se están llevando a cabo desde PCB para avanzar hacia un parque científico más sostenible. \nEl comité de sostenibilidad ha invitado a Glòria a dar esta charla que será una muy buena oportunidad para resolver todas esas dudas que nos planteamos y compartir nuestras inquietudes e ideas para tener un entorno de trabajo más sostenible. \n  \nThis seminar will be in Spanish\, a translated report will be prepared and distributed among the non-Spanish speakers. \nAll members of research groups in the process of My green lab certification are strongly encouraged to attend.
URL:https://ibecbarcelona.eu/event/sostenibilidad-en-el-pcb-spanish/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221125T100000
DTEND;TZID=Europe/Madrid:20221125T120000
DTSTAMP:20260404T005804
CREATED:20221116T090407Z
LAST-MODIFIED:20221116T090407Z
UID:101122-1669370400-1669377600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Maria Gallo and Nimesh Chahare
DESCRIPTION:Generation Of Reporter Human Pluripotent Stem Cell Lines To Study Cardiac Development And Disease\nMaria Gallo\, Pluripotency for organ regeneration Group \nThe development and the use of human pluripotent stem cells (hPSCs) represent an effective tool to recapitulate characteristics related to tissue differentiation\, morphogenesis and conversely\, human diseases. Through their inherent capacity to differentiate towards the three germ layers and their easy manipulation\, it has been possible to generate three dimensional (3D) self-organized organ-like structures\, the so-called organoids. In this context\, the advent of CRISPR-Cas9 technology has now allow to incorporate permanent or transient changes in the genome of living organisms and cells. Our laboratory has developed a cellular platform\, named iCRISPR2 (iC2)\, that allows to perform highly efficient genome editing in hPSCs through the insertion of an inducible Cas9 under the endogenous TET/ON promoter. This platform allowed us the generation of reporter\, knock-out and knock-in hPSCs lines. By exploiting the generation of cardiac reporter cell lines it has been possible to define new approaches for the generation of self-assembled cardiac-like organoids. Cardioids have been characterized at conventional molecular biology techniques\, confocal microscopy and functional analysis. Moreover\, taking advantages of specific cell culture conditions emulating early stages of diabetic cardiomyopathy it has been possible to establish a platform for the interrogation of transcriptional and functional changes during diabetic disease. \n\nMechanics of epithelial layers subjected to controlled pressure\nNimesh Chahare\, Integrative cell and tissue dynamics Group \nEpithelial sheets form specialized 3D structures suited to their physiological roles\, such as branched alveoli in the lungs\, tubes in the kidney\, and villi in the intestine. To generate and maintain these structures\, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses\, viscoelasticity\, and luminal pressure remains poorly understood. To address this question\, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup\, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure\, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach\, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However\, under sudden pressure reductions\, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-maria-gallo-and-nimesh-chahare/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221121T183000
DTEND;TZID=Europe/Madrid:20221121T193000
DTSTAMP:20260404T005804
CREATED:20221117T152328Z
LAST-MODIFIED:20221117T152546Z
UID:101231-1669055400-1669059000@ibecbarcelona.eu
SUMMARY:L’estat de la Ciència a Catalunya
DESCRIPTION:La investigació científica i tecnològica ha estat una de les claus del progrés de la societat de forma exponencial en els darrers anys. Aquesta investigació\, però\, només es pot portar a terme quan es té un ecosistema ric que permet als investigadors començar la seva tasca i desenvolupar-se. Quina és la situació actual a Catalunya? Quin és el marc català i quina és la perspectiva de futur? En parlem en aquesta sessió.\nA càrrec de Josep Samitier Martí\, director de l’Institut de Bioenginyeria de Catalunya (IBEC) i president de l’Associació Catalana d’Entitats de Recerca (ACER)\nPresenta l’acte: Aleix Ràmia\, ponent de la Secció. \n 
URL:https://ibecbarcelona.eu/event/101231/
LOCATION:Ateneu Barcelonès\, Canuda 6\, Barcelona\, 08002
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221118T090000
DTEND;TZID=Europe/Madrid:20221118T163000
DTSTAMP:20260404T005804
CREATED:20221028T104336Z
LAST-MODIFIED:20221028T104336Z
UID:99987-1668762000-1668789000@ibecbarcelona.eu
SUMMARY:Phys2BioMed Symposium
DESCRIPTION:Phys2BioMed Symposium\nPresent and future of mechanics of cells and tissues in health and disease\nThe mechanical properties of biological samples may provide insights into many physiological and pathological processes. Examples are the mechanical properties of cancer cells or changes of mechanical properties during cell invasion. Defining standardized procedures for nanomechanical measurements and providing\, in the longer-term\, a data bank of mechanical fingerprints of diseases\, can lead to the development of effective early-diagnostic tools. \nPhys2BioMed is an ITN (Innovative Training Network) that has the purpose of providing scientific and technological outcomes on biomechanics and mechanical determinants of diseases. The key advantage is merging diverse competences at the European level\, from different fields like nanoscience and nanotechnology\, physics\, biology\, and medicine. Thanks to the participation of hospitals and companies\, ESRs (Early Stage Researchers) are exposed also to the non-academic sector. \nThe scientific community is invited to participate in person or online in this symposium. \nCheck for the programme and register here.
URL:https://ibecbarcelona.eu/event/phys2biomed-symposium/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221111T100000
DTEND;TZID=Europe/Madrid:20221111T120000
DTSTAMP:20260404T005804
CREATED:20221104T105722Z
LAST-MODIFIED:20221104T105722Z
UID:100305-1668160800-1668168000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Astrid Viciano
DESCRIPTION:Is the price of pharmaceutical drugs justified?\nAstrid Viciano\, IBEC \n10 euros\, 1000 euros\, or rather 1 million? Many new medicines that have recently reached the market are prohibitively expensive. But are these prices justified? Science reporter Astrid Viciano has investigated the high prices of innovative therapies. For these investigations\, she received a number of European journalism stipends. \nViciano will explain how the pharmaceutical industry calculates prices for new drugs\, and who currently determines the costs for new medications in different healthcare systems. Looking into different\, concrete examples such as the drug Zolgensma for the treatment of spinal muscular atrophy\, she will point out how drugs are currently developed and approved\, and how medications for orphan diseases are developed. Moreover\, looking into historic examples such as insulin\, she will look into why access to potentially life-saving drugs is still not guaranteed in all regions of the world\, an urgent problem the Covid-19 pandemic has highlighted in the past two years. \n\nDr. Astrid Viciano has been working as a science journalist for German national media such as Süddeutsche Zeitung\, Die Zeit\, Spiegel\, and GEO for more than 20 years. \nShe has worked in a variety of European cross-border teams\, focusing on in-depth investigative science reporting.  From 2012 to 2016\, she worked as a freelance reporter from Paris\, and from 2009 and 2011 in Los Angeles. She has published articles in German\, English\, Dutch and Spanish. Viciano has won several national and international journalism awards\, grants\, and fellowships. \nAstrid Viciano is a medical doctor with a doctorate in immunology and virology and also has an M.A. in Specialized Journalism (USC Annenberg ’11). Currently she is „journalist-in-residence“ at IBEC. She holds the Spanish and German nationalities.
URL:https://ibecbarcelona.eu/event/ibec-seminar-astrid-viciano/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221109T160000
DTEND;TZID=Europe/Madrid:20221109T180000
DTSTAMP:20260404T005804
CREATED:20221028T104835Z
LAST-MODIFIED:20221028T104906Z
UID:100158-1668009600-1668016800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Takashi Hiiragi
DESCRIPTION:Multicellular coordination in context\nTakashi Hiiragi\, Hubrecht Institute\, The Netherlands \nA defining feature of living systems is the capacity to break symmetry and generate well-defined forms and patterns through self-organisation. Our group aims to understand the design principle of multicellular living systems using early mouse embryos as a model system. We developed an experimental framework that integrates biology\, physics and mathematics\, to understand how molecular\, cellular and physical signals are dynamically coupled across the scales for self-organisation. I will discuss our ongoing work investigating the coordination of developmental programmes in space and time. \n\nTakashi Hiiragi is group leader at the Hubrecht Institute.  The Hiiragi group aims to understand what defines multi-cellular living systems. In particular\, the group studies the design principle of tissue self-organization\, using early mammalian embryos as a model system. To this end\, they developed an experimental framework that integrates biology\, physics and mathematics. Their recent studies led to a model in which feedback between cell fate\, polarity\, and cell and tissue mechanics underlies multi-cellular self-organization. The group adopts a wide variety of experimental strategies including embryology\, genetics\, advanced microscopy\, biophysics\, engineering and theoretical modelling\, in order to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-takashi-hiiragi/
LOCATION:Sala Baobab\, Tower I - 11th floor
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221102T153000
DTEND;TZID=Europe/Madrid:20221102T173000
DTSTAMP:20260404T005804
CREATED:20221025T111442Z
LAST-MODIFIED:20221031T092456Z
UID:100038-1667403000-1667410200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Felipe Galvez-Cancino (canceled)
DESCRIPTION:
URL:https://ibecbarcelona.eu/event/ibec-seminar-felipe-galvez-cancino/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221028T100000
DTEND;TZID=Europe/Madrid:20221028T120000
DTSTAMP:20260404T005804
CREATED:20221004T082238Z
LAST-MODIFIED:20221004T082238Z
UID:99604-1666951200-1666958400@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills Session: Astrid Viciano
DESCRIPTION:Science Journalism\nAstrid Viciano\, IBEC \nWe are continuously exposed to all sorts of information on science and health\, with a sharp increase during the past years of the Covid-19 pandemic. Therefore\, the role of science writers in communicating science to the general public is becoming increasingly important. With scientific knowledge expanding at a tremendous pace\, writers who are able to understand scientific studies and scientists’ claims  and translate their work for the general public are in high demand. \nHow do science journalists choose the topics they write about? How to they select the experts to speak with? And what career paths can lead into science journalism? Looking at concrete examples from the German and European media landscape\, the underlying rules of science journalism will be explained. \n\nDr. Astrid Viciano has been working as a science journalistfor German national media such as Süddeutsche Zeitung\, Die Zeit\, Spiegel\, and GEO for more than 20 years. \nShe has been working in a variety of European cross-border teams\, focusing on in-depth investigative science reporting.  From 2012 until 2016\, she worked as a freelance reporter from Paris\, from 2009 and 2011 she worked from Los Angeles. She has published articles in German\, English\, Dutch and Spanish. Viciano has won several national and international journalism awards\, grants\, and fellowships. \nAstrid Viciano is a medical doctor (doctorate: immunology and virology)\, and also holds a M.A. in Specialized Journalism (USC Annenberg ’11). Currently she is „journalist-in-residence“ at IBEC. She is Spanish and German.
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-session-astrid-viciano/
LOCATION:IBEC\, floor 11\, tower i
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221019T090000
DTEND;TZID=Europe/Madrid:20221019T090000
DTSTAMP:20260404T005804
CREATED:20220711T101638Z
LAST-MODIFIED:20220927T124827Z
UID:92711-1666170000-1666170000@ibecbarcelona.eu
SUMMARY:15th IBEC Symposium: Bioengineering for Active Aging
DESCRIPTION:The 15th IBEC annual Symposium will be celebrated on cite at Hotel Alimara. We hope to meet you all there as this is a great opportunity to bring everyone from IBEC community together. \n\n\n\nThe 15th IBEC annual Symposium brings together high-profile international experts for an open forum for interdisciplinary discussions and networking. This year the symposium is dedicated to Bioengineering for Active Ageing\, one of IBEC’s three major application areas. \n\n\n\nScientific community is invited to participate. Attendees from IBEC and abroad are welcome to present their research or projects in poster format. Moreover\, some of these contributions will be selected by the scientific committee for an oral flash presentation. \n\n\n\nAlso\, it is important that you submit your abstract and register at the same time. \n\n\n\n\n\n\n\nIMPORTANT DEADLINES 2022: \n\n\n\nAbstract submission:  31st July \n\n\n\nNotification of acceptance: 19th September \n\n\n\nRegistration deadline: 10th October \n\n\n\n\n\n\n\nWe invite you to register and\, if you wish\, to submit an abstract athttps://events.ibecbarcelona.eu/ibec-symposium-2022/
URL:https://ibecbarcelona.eu/event/15th-ibec-symposium/
LOCATION:Hotel Alimara\, Carrer de Berruguete\, 126\, Barcelona\, 08035
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
ATTACH;FMTTYPE=image/jpeg:https://ibecbarcelona.eu/wp-content/uploads/2022/07/SYM2022_bannerhome.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221014T100000
DTEND;TZID=Europe/Madrid:20221014T120000
DTSTAMP:20260404T005804
CREATED:20220513T064645Z
LAST-MODIFIED:20220513T064645Z
UID:96616-1665741600-1665748800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Conrado Aparicio
DESCRIPTION:
URL:https://ibecbarcelona.eu/event/ibec-seminar-conrado-aparicio-2-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221014T100000
DTEND;TZID=Europe/Madrid:20221014T120000
DTSTAMP:20260404T005804
CREATED:20220513T064645Z
LAST-MODIFIED:20220513T064645Z
UID:96618-1665741600-1665748800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Conrado Aparicio
DESCRIPTION:
URL:https://ibecbarcelona.eu/event/ibec-seminar-conrado-aparicio-2-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221014T100000
DTEND;TZID=Europe/Madrid:20221014T120000
DTSTAMP:20260404T005804
CREATED:20220513T064645Z
LAST-MODIFIED:20221004T083638Z
UID:96615-1665741600-1665748800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Conrado Aparicio
DESCRIPTION:Peptides and bioinstructive polymers on surfaces for prevention of oral infections\nConrado Aparicio\, Faculty of Odontology\, UIC Barcelona and Associated Researcher – IBEC \nOral infections are the most prevalent infectious diseases worldwide. We have explored bioinspired modification of surfaces of restorative/regenerative materials and implants as well as dental tissues to address oral infections by harnessing the biomolecular toolbox –oligopeptides\, proteins\, recombinamers\, … and thus\, mitigating the worldwide threat of antimicrobial resistance. \nOne of our strategies aimed at exploiting secondary structure and self-assembly of anti-biofilm peptides and recombinamers to increase anti-biofilm potency vs relevant oral biofilms and to form highly hydrophobic interfaces to obtain dual-action surfaces to address infection in dental peri-tisular and peri-implant sites. \nAlternatively\, we have found inspiration in the natural junction at the tooth-oral mucosa interface. Teeth\, long-lasting percutaneous organs\, feature soft tissue attachment through adhesive structures\, hemidesmosomes\, in the junctional epithelium basement membrane adjacent to teeth. This soft tissue attachment prevents bacterial infection of the tooth despite the rich – and harsh – microbial composition of the oral cavity. Consequently\, we have tapped basement membrane peptides known to engage specific integrins as well as synthesized new bioinstructive photocurable resins that stimulate formation of hemidesmosomes on synthetic and natural surfaces. \nWe recently have also combined those strategies with immunomodulatory regulation to reduce inflammation triggered by pathogenic biofilms causing oral infections. \n\nDr. Conrado Aparicio is Professor at the Department of Odontology of UIC Barcelona – Universitat International de Catalunya\, Spain. He is associated researcher at IBEC-Institute for BioEngineering of Catalonia and elected fellow of the AIMBE-American Institute for Medical and Biological Engineering. \nDr. Aparicio is a materials scientist and engineer by training. After starting his academic career at the Technical University of Catalonia (UPC) he moved to the University of Minnesota (UMN) where he spent 12+ years in the Department of Restorative Sciences\, and was the Deputy Director of the MDRCBB-Minnesota Dental Research Center for Biomaterials and Biomechanics. Last year Professor Aparicio returned to his hometown\, Barcelona\, as FBA-BIST-UIC fellow. \nFor two decades he has carried out multidisciplinary research on bioinspired biomaterials and interfaces for directing biological responses to repair/regenerate bone and oral mucosa as well as to prevent bacterial infections for dental applications. Using inspiration from nature’s molecules and structures\, his team designs and develops bioactive surfaces using supramolecular assembly and enabling spatial-temporal control of bioactive responses. \nHe has published 130+ research papers and has lectured around the World on bioactivation of synthetic biomaterials for reparative and regenerative dentistry and medicine. He is co-inventor of multiple patents\, one of them licensed and marketed by a dental implant company. He has been awarded multiple national and international research projects from US and EC agencies\, foundations and corporations\, in interdisciplinary collaborations between academic and corporate engineers\, biologists\, and clinicians.
URL:https://ibecbarcelona.eu/event/ibec-seminar-conrado-aparicio-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221010T100000
DTEND;TZID=Europe/Madrid:20221010T100000
DTSTAMP:20260404T005804
CREATED:20220922T094736Z
LAST-MODIFIED:20220922T101148Z
UID:99385-1665396000-1665396000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Enrico Almici
DESCRIPTION:Investigating pathological extracellular matrix architecture\nAuthor: ENRICO ALMICI\, Nanobioengineering \nThis thesis defence will take place at “Sala de Graus Eduard Fontseré. Facultat de Física” at 10:00h. \n\nPresident: Dr. Sergio Cerutt \nSecretària: Dra. Elena Martinez Fraiz \nVocal: Dr. Eugenio Martinelli \n  \nSuplents: \nDra. Noemi Reguart Aransay \nDra. Valeria Chiono \n  \nDirectors: \nDr. JOAN MONTERO BORONAT \nDr. JOSEP SAMITIER MARTI \nDr. JORDI ALCARAZ CASADEMUNT \n  \nTutor: Dr. JOSEP SAMITIER MARTI
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-enrico-almici/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221005T100000
DTEND;TZID=Europe/Madrid:20221005T120000
DTSTAMP:20260404T005804
CREATED:20220919T080717Z
LAST-MODIFIED:20220927T081412Z
UID:99361-1664964000-1664971200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Odde
DESCRIPTION:Differential migration mechanics and immune response of glioblastoma subtypes\nDavid Odde\, Dept. of Biomedical Eng.\, U. Minnesota \nGlioblastoma remains a deadly cancer driven by invasion of tumor cells into the brain. Transcriptomic analyses have revealed distinct molecular subtypes\, but mechanistic and targetable differences that explain clinical differences are not clear. Using a state-of-the-art immunocompetent mouse model for glioblastoma – where tumors are induced by injection of plasmids containing human glioblastoma subtype-defining genetic drivers in a wild-type background – we found that\, as predicted by the motor-clutch model for cell migration (Klank et al.\, Cell Rep\, 2017)\, mesenchymal glioma cells are more spread\, generate larger traction forces\, and migrate faster in brain tissue compared to proneural cells. Despite their fast migration and comparable proliferation rate in vitro\, mice with mesenchymal tumors live longer than mice with proneural tumors\, which was correlated with an immune response in the mesenchymal mice that included T cell-mediated killing of cancer cells\, similar to human tumors. Thus\, mesenchymal tumors have aggressive migration\, but are relatively immunologically ‘hot’ which suppresses net proliferation\, features which are captured by our Brownian Dynamics tumor simulator (Klank et al.\, Conv Sci Phys Oncol\, 2018). These two features counteract each other and may explain the lack of a strong survival difference between subtypes clinically\, while also opening up new opportunities for subtype-specific therapies. \n  \n\nDavid Odde is the Medtronic Professor of Engineering in Medicine at the University of Minnesota. Trained as a chemical engineer at the University of Minnesota and Rutgers University\, Odde joined the newly created Department of Biomedical Engineering at the University of Minnesota in 1999 where he is a professor and Associate Director for Strategic Research Initiatives in the Institute for Engineering in Medicine. In his research\, Odde’s group builds computer models of cellular and molecular self-assembly and force-generation-dissipation dynamics\, and tests the models experimentally using digital microscopic imaging of living cells ex vivo and in engineered microenvironments. His group seeks to bring an engineering approach that uses physics-based modeling and analysis to understand\, predict\, and control disease outcomes (oddelab.umn.edu). Dr. Odde is an elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, the Biomedical Engineering Society (BMES)\, the International Academy of Medical and Biological Engineering (IAMBE)\, and the American Association for the Advancement of Science (AAAS) and is the Director of the Physical Sciences in Oncology Center at the University of Minnesota (psoc.umn.edu)\, which is focused on modeling the mechanics of cancer cell migration in biologically relevant contexts.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-odde/
LOCATION:Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220930T100000
DTEND;TZID=Europe/Madrid:20220930T120000
DTSTAMP:20260404T005804
CREATED:20220927T125737Z
LAST-MODIFIED:20220927T125737Z
UID:99444-1664532000-1664539200@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills Session: M.ª Ángeles García Asensio.
DESCRIPTION:Tips for a good scientific Communication\nM.ª Ángeles García Asensio\, Comunicació Audiovisual – Facultat d’Informació i Mitjans Audiovisuals (UB) \nGiving presentations is an important part of sharing your work and achieving recognition in the scientific communities. This workshop covers essential skills to convey your ideas and to communicate powerfully and effectively. We will learn how to engage audiencies facing two major facets to a presentation: the content and how you present it. With our tips for good scientific communication\, you will avoid the pitfalls that put audiences to sleep. \n\nMª Ángeles García Asensio holds a PhD in Linguistics (Spanish) from the University of Barcelona (Spain). She is an Associate Professor in the Department of Spanish Philology at the University of Barcelona and in the School of Media Studies. Her work is focused on Spanish for Specific Purposes (Professional Discourse)\, aiming to propose strategies to improve the effectiveness of written and digital texts and to design professional writing techniques for multimodal discourses. \nShe also combines the university tasks with knowledge transfer through the Bosch i Gimpera Foundation and StartUB\, the unit that coordinates\, promotes and develops entrepreneurship among the community of the University of Barcelona\, offering courses in persuasive oral communication techniques. \nAs a communication coach\, she collaborates with companies and associations. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-session-m-a-angeles-garcia-asensio/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220927T170000
DTEND;TZID=Europe/Madrid:20221001T093000
DTSTAMP:20260404T005804
CREATED:20220331T080224Z
LAST-MODIFIED:20220331T080224Z
UID:96577-1664298000-1664616600@ibecbarcelona.eu
SUMMARY:Mechanobiology of cancer summer school 2022
DESCRIPTION:The MECHANO·CONTROL consortium\, led by several research institutions across Europe\, is launching the second edition of the “Mechanobiology of Cancer” summer school\, which will take place between  September 27th –  October 1st at the Eco Resort in La Cerdanya. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nThe summer school aims to provide training on mechanobiology\, and specifically its application to cancer.\nThis school will include lectures as well as practical workshops in different techniques and disciplines\, ranging from modeling to biomechanics to cancer biology. \nThere will be scientific sessions in the morning\, mixing 6 keynote speakers with short talks selected from abstract submissions by junior scientists attending the school and a poster session. In the afternoon\, there will be 2-3-hour practical workshops\, given by scientists from the MECHANO·CONTROL consortium. The course will also include leisure activities. \nThe 6 confirmed speakers who will attend the summer school are: \n\nDagmar Iber (ETH Zurich)\nHans Van Oosterwyck (KU Leuven)\nClaudia Fischbach (Director of Cornell’s Physical Sciences Oncology)\nGiorgio Scita (IFOM – The Firc Institute Of Molecular Oncology)\nMadeleine J. Oudin (Tufts University)\nMaria Celeste Aragona (University of Copenhagen)\n\nAttendance to the Summer School is open to all students\, post-docs\, and professionals interested\, although priority will be given to junior scientists (up to the post-doctoral stage). \n\nApplication deadline:\n9th May 2022 \nAcceptance and registration:\n17th June 2022
URL:https://ibecbarcelona.eu/event/mechanobiology-of-cancer-summer-school-2022/
LOCATION:La Cerdanya Eco-Resort
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220927
DTEND;VALUE=DATE:20220928
DTSTAMP:20260404T005804
CREATED:20220331T080224Z
LAST-MODIFIED:20220927T125023Z
UID:96579-1664236800-1664323199@ibecbarcelona.eu
SUMMARY:Mechanobiology of cancer summer school 2022
DESCRIPTION:The MECHANO·CONTROL consortium\, led by several research institutions across Europe\, is launching the second edition of the “Mechanobiology of Cancer” summer school\, which will take place between  September 27th –  October 1st at the Eco Resort in La Cerdanya. \n\n\n\n\n\n\n\n\n\n\n\n\nThe summer school aims to provide training on mechanobiology\, and specifically its application to cancer.This school will include lectures as well as practical workshops in different techniques and disciplines\, ranging from modeling to biomechanics to cancer biology. \nThere will be scientific sessions in the morning\, mixing 6 keynote speakers with short talks selected from abstract submissions by junior scientists attending the school and a poster session. In the afternoon\, there will be 2-3-hour practical workshops\, given by scientists from the MECHANO·CONTROL consortium. The course will also include leisure activities. \nThe 6 confirmed speakers who will attend the summer school are: \n\nDagmar Iber (ETH Zurich)\nHans Van Oosterwyck (KU Leuven)\nClaudia Fischbach (Director of Cornell’s Physical Sciences Oncology)\nGiorgio Scita (IFOM – The Firc Institute Of Molecular Oncology)\nMadeleine J. Oudin (Tufts University)\nMaria Celeste Aragona (University of Copenhagen)\n\nAttendance to the Summer School is open to all students\, post-docs\, and professionals interested\, although priority will be given to junior scientists (up to the post-doctoral stage). \n\nApplication deadline:9th May 2022 \nAcceptance and registration:17th June 2022
URL:https://ibecbarcelona.eu/event/mechanobiology-of-cancer-summer-school-2022/
LOCATION:Spain
CATEGORIES:External symposium / conference / congress,Other
ATTACH;FMTTYPE=image/png:https://ibecbarcelona.eu/wp-content/uploads/2022/03/595ec8f2-8b49-4c97-9cc7-17e8b603cb60.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220916T120000
DTEND;TZID=Europe/Madrid:20220916T140000
DTSTAMP:20260404T005804
CREATED:20220909T111057Z
LAST-MODIFIED:20220914T075527Z
UID:99029-1663329600-1663336800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maximilian Loeck
DESCRIPTION:Comparative study of nanocarries targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes\n\n\n\nAuthor: Maximilian Loeck\, Targeted therapeutics and nanodevices \n\n\n\nThis thesis defence will take place at “Aula 14 (Dolors Aleu i Riera)\, Campus Clínic” at 12:30h. \nAddress: Facultad de Medicina\, Carrer de Casanova\, 143\, 08036 Barcelona
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maximilian-loeck/
LOCATION:Carrer de Casanova\, 143\, Campus Clínic\, Barcelona\, 08036
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220914T150000
DTEND;TZID=Europe/Madrid:20220914T170000
DTSTAMP:20260404T005804
CREATED:20220907T104718Z
LAST-MODIFIED:20220907T104744Z
UID:98985-1663167600-1663174800@ibecbarcelona.eu
SUMMARY:IBEC-IRB joint seminar
DESCRIPTION:Aberrant phase separation is a widespread killing mechanism of bioactive peptides in health and diseas\n\n\n\nSteven Boeynaems\, Assistant Professor at Baylor College of Medicine and Investigator at the Texas Children’s Hospital \n\n\n\nCationic repeat peptides are increasingly implicated in the pathophysiology of age-related neurodegenerative disease. These peptides are highly toxic in all tested disease models\, and seem to perturb an ever-expanding list of cellular pathways. This observation begs the question whether this target promiscuity is (1) relevant to disease and (2) how it is encoded in such simple sequences. A first clue came from the observation that these cationic repeat peptides have the tendency to drive protein condensation. Given their charge\, these peptides are exquisitely sensitive to the presence of nucleic acids. By studying their target space as a function of RNA concentration using mass spec\, we uncover a hidden hierarchy in their target preference that relates to subcellular differences in RNA abundance.  \n\n\n\nTo test whether these insights from disease translate to biology\, we used this framework to develop a machine learning algorithm that allowed us to predict protein behavior form sequence. Compellingly\, we uncover that bioactive peptides such as antimicrobial peptides produced by our own cells\, but also venom peptides derived from spiders\, scorpions and rattle snakes\, phenocopy the molecular behavior of these disease-related cationic peptides. In all\, we find that such peptides exert toxicity by upsetting the electrostatic balance of a cell\, hitting myriad pathways at once. We name this process polycation poisoning and find that it has independently evolved again and again across the entire tree of life as a killing strategy of bioactive peptides. Based on these findings we are now exploring toxin-antitoxin systems as innovative therapeutic strategies to protect neurons against cationic repeat peptide toxicity. \n\n\n\nHosts: Benedetta Bolognesi and Xavier Salvatella \n\n\n\nPlace: Felix Serratosa Hall\, PCB
URL:https://ibecbarcelona.eu/event/ibec-irb-joint-seminar/
LOCATION:Aula Félix Sarratosa\, PCB
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220909T100000
DTEND;TZID=Europe/Madrid:20220909T120000
DTSTAMP:20260404T005804
CREATED:20220829T080856Z
LAST-MODIFIED:20220829T081341Z
UID:98514-1662717600-1662724800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Myriam M. Chaumeil
DESCRIPTION:Imaging metabolism in neurological disorders\n\n\n\nAssociate Professor in Residence\, Departments of Physical Therapy and Rehabilitation Science & Radiology and Biomedical Imaging\, UCSFInvestigator\, Quantitative Bioscience Institutes (QBI)Lab website : Chaumeil Lab\, UCSF \n\n\n\nOur lab works on developing and biologically validating magnetic resonance (MR)-based metabolic imaging approaches using animal models of neurological diseases (such as genetically-engineered or toxin-induced). In this talk\, I will present how optimized acquisitions strategies\, based mostly on the hyperpolarized DNP-MR technology\, can be used for improved diagnosis and treatment monitoring of neurological diseases\, including multiple sclerosis\, chronic traumatic encephalopathy and Alzheimer’s disease. I will also show how we use metabolomics approaches to identify potential pathways modified in disease\, and normalized with treatment\, with an example focusing on interneuron transplantation as a treatment for epilepsy. \n\n\n\n\n\n\n\nDr. Chaumeil is an Associate Professor in Residence in the department of Physical Therapy & Rehabilitation Science and Radiology & Biomedical Imaging at UCSF\, a faculty member of three graduate programs (UCSF/UC Berkeley BioEngineering; UCSF Biomedical Science and UCSF Rehabilitation Science)\, and an investigator in the Quantitative Biosciences Institute. Her research focuses on developing new neuroimaging methods to improve the diagnosis and monitoring of neurological disorders\, such as Alzheimer’s disease\, Multiple Sclerosis or vascular dementia. She is a Junior Fellow of the International Society of Magnetic Resonance in Medicine\, and has been recently elected on the board of the ISMRM Hyperpolarized Study group. Dr. Chaumeil grew up in the south of France\, and received her engineer degree and her PhD degree in Paris\, before moving across the world to California to join UCSF. \n\n\n\n \n\n\n\nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/ibec-seminar-myriam-m-chaumeil/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220908T100000
DTEND;TZID=Europe/Madrid:20220908T130000
DTSTAMP:20260404T005804
CREATED:20220727T094315Z
LAST-MODIFIED:20220901T082701Z
UID:98246-1662631200-1662642000@ibecbarcelona.eu
SUMMARY:IBEC-IFIBYNE joint seminar
DESCRIPTION:10:00Institutional WelcomeJosep SamitierIBEC10:10Presentation by IFIBYNE directorAdali PecciIFIBYNE10:30Training-on-a-Chip: a multi-organ device to study the effect of muscle exercise on insulin secretion in vitroJavier RamónIBEC10:50Coffee Break11:20Genomic regulation in pancreatic beta cell development and regenerationSantiago RodríguezIFIBYNE11:40TBDRomén RodríguezIBEC12:00Closing\n\n\n\nThe seminar will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/ibec-ifibyne-joint-seminar/
LOCATION:Sala Baobab\, C/Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220722T080000
DTEND;TZID=Europe/Madrid:20220722T170000
DTSTAMP:20260404T005804
CREATED:20220722T093907Z
LAST-MODIFIED:20220722T094126Z
UID:97829-1658476800-1658509200@ibecbarcelona.eu
SUMMARY:2022 BIST Conference on Precision Medicine
DESCRIPTION:Precision Medicine: Putting discoveries to work\n\n\n\n\n\n\n\nThe Barcelona Institute of Science and Technology (BIST) is pleased to announce its 2022 BIST Conference to discuss the latest developments in an area of priority for BIST research\, this year focusing on Precision Medicine.The Conference will take place on November 10\, in the city of Barcelona. It will include keynote talks\, round-tables\, and selected flash-talks and posters on the topic of Precision Medicine. As in the past year\, the Conference will include satellite events.\n\n\n\nCall for abstractsThe main Conference session on November 10 will include selected 5-minute-long flash talks and a poster session on topics related to Precision Medicine. We invite you to submit your abstract though the form by September 10\, 2022.Instructions for abstract submission: \n\n\n\nPrepare your abstract in a word document to submit. The abstract should include: title\, authors with affiliations\, and a summary of maximum 250 words.During the abstract submission\, you will be asked to choose one of the following topics:DevicesGenetics and genomicsHigh-throughput technologiesModeling (e.g.: stem cells\, organoids\, systems biology)Non-invasive monitoring and imagingPrecision therapies (e.g.: CAR-T)Testing and biomarkers\n\n\n\nA public book of abstracts will be prepared for the Conference. \n\n\n\nYou can submit your abstract here. \n\n\n\nThere is no registration fee for this Conference. \n\n\n\nThe abstracts will be evaluated by the Conference Scientific Committee\, composed by Jorge Ferrer from CRG; Núria Montserrat and Irene Marco Rius from IBEC; Turgut Dururan from ICFO; José A. Garrido and Víctor Puntes from ICN2; and Patrick Aloy and Cayetano Gonzalez from IRB Barcelona.The 2022 BIST Conference\, and especially the Satellite Sessions\, are being prepared by the Organizing Committee\, formed by Gloria Lligadas from CRG; Anke Kleff from IBEC; Lydia Sanmartí from ICFO; Mónica H. Pérez-Temprano from ICIQ; Àlex Argemí from ICN2; and Zoila Babot\, Marta Llorens and Gabby Silberman from BIST.
URL:https://ibecbarcelona.eu/event/2022-bist-conference/
LOCATION:Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220715T100000
DTEND;TZID=Europe/Madrid:20220715T120000
DTSTAMP:20260404T005804
CREATED:20220503T132602Z
LAST-MODIFIED:20220503T132602Z
UID:91660-1657879200-1657886400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Marc Azagra and Inês Sousa
DESCRIPTION:Novel Nuclear Magnetic Resonance (NMR) applications in the clinical field\nMarc Azagra\, Molecular Imaging for Precision Medicine Group \nWhen nuclear magnetic resonance (NMR) was described more than half a century ago it appeared to be a curiosity of the quantum world. Since then NMR spectroscopy has become an essential tool not only for chemists\, but also for biochemists\, molecular biologists and even clinicians. Today we are going to explain what is Hyperpolarization NMR\, main differences with thermal NMR acquisitions and two of the projects I am involved with: a new NMR application in clinical diagnosis stage for Liver disease and the first experiment ever performed with High-throughput Hyperpolarized Magnetic Resonance Imaging experiment with a multiwell microfluidic chips using Chemical Shift Imaging (CSI) pulse sequence. \n\n\nVersatile gelatine-based biomaterials compatible with neuronal differentiation: Applications in different systems for brain modelling\nInês Sousa Pereira\, Nanobioengineering Group \nTissue engineering has been focused on recreating the tissue environment of many organs\, such as the brain\, for modelling and for therapeutic approaches during the last years. Recently\, 3D brain in vitro models have been explored as they resemble more accurately physiological conditions of this organ. However\, neuronal cultures are challenging due to the high sensitivity of these cells to changes in their surroundings. \nWe present a hydrogel composed of methacrylated gelatine (GeIMA)\, alginate (AlgMA) and hyaluronic acid (HA) for neural progenitor cell culture in this work. Our goal was to assess the compatibility of GelMA and AlgMA composites with neuronal culture as these two materials are common in tissue engineering applications. HA was added to better mimic the stiffness of the brain tissue. Neuroprogenitor mouse cell line C17.2 was embedded in the gelatine-based formulations and cultured as 3D scaffold in a drop shape or inserted in a microfluidic device. They were also used as bioinks for extrusion bioprinting. We performed the physical characterization of both formulations\, viability studies\, immunostainings to assess the differentiation process and calcium imaging to validate the activity of the cells. \nResults show that hydrogels with and without hyaluronic acid have good porosity\, allowing nutrient and oxygen diffusion. They also present low Young Modulus\, especially for hyaluronic acid formulation\, rendering values similar to the brain tissue.\, the viability of the cells as well as the cell differentiation and connectivity were high after 28 days in culture In the assays with the formulations as scaffolds. The activity of the cells was assessed at day 8 and increased by day 15 for both formulations\, showing that cells were differentiating\, and the neuronal network was maturating. In the bioprinting assays\, the formulations presented high cell viability up to 15 days after printing and day 15 immunostaining showed the expression of neuroprogenitor marker nestin and early neuron marker β-III tubulin. On 3D-brain on the chip assays\, the both formulations had high cell viability up until day 15 of culture\, increasing expression of β-III tubulin as well as cell activity. \nIn conclusion\, our formulations allow long-term cell culture\, including high expression of neuronal markers\, cell connectivity and activity and the presence of HA gave the hydrogel physical characteristics closer to brain tissue while permitting a high cell viability and allowing the differentiation of C17.2 cells. These biomaterials are also suitable as bioinks for extrusion in a bioprinter as proven by the good viability of the cells and the compatibility with the differentiation process. The formulations were also tested in a microfluidic system\, maintaining the viability\, differentiation\, and activity capacities of the cells. Overall\, these results make these hydrogels a promising scaffold for brain modelling\, applicable to 3D long-term culture and differentiation of cells\, such as iPSC-derived neurons. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220715T100000
DTEND;TZID=Europe/Madrid:20220715T120000
DTSTAMP:20260404T005804
CREATED:20220503T132602Z
LAST-MODIFIED:20220503T132602Z
UID:96603-1657879200-1657886400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Marc Azagra and Inês Sousa
DESCRIPTION:Novel Nuclear Magnetic Resonance (NMR) applications in the clinical field\nMarc Azagra\, Molecular Imaging for Precision Medicine Group \nWhen nuclear magnetic resonance (NMR) was described more than half a century ago it appeared to be a curiosity of the quantum world. Since then NMR spectroscopy has become an essential tool not only for chemists\, but also for biochemists\, molecular biologists and even clinicians. Today we are going to explain what is Hyperpolarization NMR\, main differences with thermal NMR acquisitions and two of the projects I am involved with: a new NMR application in clinical diagnosis stage for Liver disease and the first experiment ever performed with High-throughput Hyperpolarized Magnetic Resonance Imaging experiment with a multiwell microfluidic chips using Chemical Shift Imaging (CSI) pulse sequence. \n\n\nVersatile gelatine-based biomaterials compatible with neuronal differentiation: Applications in different systems for brain modelling\nInês Sousa Pereira\, Nanobioengineering Group \nTissue engineering has been focused on recreating the tissue environment of many organs\, such as the brain\, for modelling and for therapeutic approaches during the last years. Recently\, 3D brain in vitro models have been explored as they resemble more accurately physiological conditions of this organ. However\, neuronal cultures are challenging due to the high sensitivity of these cells to changes in their surroundings. \nWe present a hydrogel composed of methacrylated gelatine (GeIMA)\, alginate (AlgMA) and hyaluronic acid (HA) for neural progenitor cell culture in this work. Our goal was to assess the compatibility of GelMA and AlgMA composites with neuronal culture as these two materials are common in tissue engineering applications. HA was added to better mimic the stiffness of the brain tissue. Neuroprogenitor mouse cell line C17.2 was embedded in the gelatine-based formulations and cultured as 3D scaffold in a drop shape or inserted in a microfluidic device. They were also used as bioinks for extrusion bioprinting. We performed the physical characterization of both formulations\, viability studies\, immunostainings to assess the differentiation process and calcium imaging to validate the activity of the cells. \nResults show that hydrogels with and without hyaluronic acid have good porosity\, allowing nutrient and oxygen diffusion. They also present low Young Modulus\, especially for hyaluronic acid formulation\, rendering values similar to the brain tissue.\, the viability of the cells as well as the cell differentiation and connectivity were high after 28 days in culture In the assays with the formulations as scaffolds. The activity of the cells was assessed at day 8 and increased by day 15 for both formulations\, showing that cells were differentiating\, and the neuronal network was maturating. In the bioprinting assays\, the formulations presented high cell viability up to 15 days after printing and day 15 immunostaining showed the expression of neuroprogenitor marker nestin and early neuron marker β-III tubulin. On 3D-brain on the chip assays\, the both formulations had high cell viability up until day 15 of culture\, increasing expression of β-III tubulin as well as cell activity. \nIn conclusion\, our formulations allow long-term cell culture\, including high expression of neuronal markers\, cell connectivity and activity and the presence of HA gave the hydrogel physical characteristics closer to brain tissue while permitting a high cell viability and allowing the differentiation of C17.2 cells. These biomaterials are also suitable as bioinks for extrusion in a bioprinter as proven by the good viability of the cells and the compatibility with the differentiation process. The formulations were also tested in a microfluidic system\, maintaining the viability\, differentiation\, and activity capacities of the cells. Overall\, these results make these hydrogels a promising scaffold for brain modelling\, applicable to 3D long-term culture and differentiation of cells\, such as iPSC-derived neurons. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220701T090000
DTEND;TZID=Europe/Madrid:20220701T174500
DTSTAMP:20260404T005804
CREATED:20220623T112616Z
LAST-MODIFIED:20220623T112616Z
UID:96633-1656666000-1656697500@ibecbarcelona.eu
SUMMARY:THERACAT Conference
DESCRIPTION:Bio-orthogonal catalysis for cancer therapy (THERACAT)\n\n\nTHERACAT is a Marie Skłodowska-Curie European Training Network (MSCA-ITN-ETN) aiming to train a new generation of researchers on the innovative topic of bio-orthogonal catalysis for cancer therapy \nThe development of novel cancer therapies is a major challenge for academic research and pharmaceutical industries. Although the recent progress in traditional treatments such as surgery and chemotherapy improved the clinical outcome of cancer patients\, there is a strong need for new and effective approaches as well as for a new generation of young scientists trained to tackle these challenges from a multidisciplinary perspective. THERACAT establishes an international training programme focused on the development of catalysis-based approaches towards the cure of cancer. In this strategy nano- and micro-particles bearing a catalytic unit are delivered to the tumour site and subsequently non-active prodrugs are administered to the patient. The prodrugs are non-toxic and therefore generate limited side effects. Only at the tumour site the catalytic particles convert the prodrugs into active anticancer compounds that generate a local and strong effect\, as single catalytic species can uncage a large number of drugs. This approach presents several advantages on the classical drug delivery paradigm including limited side effects and prolonged efficacy. \nThe final aim of the THERACAT network is to consolidate Europe as the world leader in novel catalysis-based approach for cancer therapy. \n 
URL:https://ibecbarcelona.eu/event/theracat-conference/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T123000
DTEND;TZID=Europe/Madrid:20220627T133000
DTSTAMP:20260404T005804
CREATED:20220627T070730Z
LAST-MODIFIED:20220627T070730Z
UID:96639-1656333000-1656336600@ibecbarcelona.eu
SUMMARY:Last minute Seminar: Laura Suter-Dick
DESCRIPTION:Liver and Kidney: 3D-in vitro systems for disease modelling and biomarker discovery\nProf. Laura Suter-Dick\nFHNW University of Applied Sciences and Arts Northwestern Switzerland School of Life Sciences\, Institute for Chemistry and Bioanalytics a Basel.
URL:https://ibecbarcelona.eu/event/last-minute-seminar-laura-suter-dick/
LOCATION:Sala Baobab\, Tower I - 11th floor
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20220627T100000
DTEND;TZID=Europe/Madrid:20220627T140000
DTSTAMP:20260404T005804
CREATED:20220623T110756Z
LAST-MODIFIED:20220623T110756Z
UID:96636-1656324000-1656338400@ibecbarcelona.eu
SUMMARY:Biomedical signal interpretation and smartphone sensors for the assessment of trunk function and sleep disorders in patients with spinal cord injury
DESCRIPTION:Author: Yolanda del Castillo\nGroup: Biomedical Signal Processing and Interpretation\nDirectors: Raimon Jané \n  \nAbstract:\nSpinal cord injury (SCI) is one of the leading causes of disability worldwide. SCI causes motor and sensory impairment below the level of the injury\, but it is also associated with many other health complications. Two of these problems are trunk muscle impairment and sleep disorders. Impaired trunk function affects postural control and sitting balance\, which are critical for activities of daily living. Disturbed sleep causes fatigue and sleepiness and can lead to serious comorbidities\, impacting patient recovery and outcomes. However\, due to the multiple health problems secondary to SCI and the limitations in current diagnostic tools\, trunk function and sleep are rarely examined after SCI. The non-invasive acquisition and analysis of biomedical signals can help to overcome this issue\, providing quantitative measures to assess patient condition. Smartphones can facilitate this task\, thanks to their ubiquitous presence and powerful sensors.\n\n\nThe aim of this PhD thesis is to propose new smartphone-based tools and biomedical signal analysis techniques for the quantitative assessment of trunk function and sleep-disordered breathing (SDB) in patients with SCI.  This thesis is divided into two parts\, including four publications in high-impact journals. The first part addresses the characterization of trunk function in healthy subjects and patients with cervical (cSCI) and thoracic SCI (tSCI). The second part focuses on the development of a mobile health (mHealth) system based on smartphone audio signals for obstructive sleep apnea (OSA) diagnosis\, and the detection and monitoring of SDB in SCI patients.\n\nThe first part of the thesis introduces a novel methodology to quantitatively evaluate trunk function by combining electromyography (EMG) and smartphone accelerometry. In the first study\, we characterized the muscle activity and movement patterns of trunk flexion during reaching in healthy humans and investigated if trunk stability was affected by a startling acoustic stimulus (SAS). We found that SAS markedly reduced the response time (RespT) and EMG onset latencies of all muscles (the so-called StartReact effect)\, either prime movers or stabilizers. In the second study\, we evaluated trunk function and the effects of a SAS in patients with cSCI and tSCI. The results revealed deficits in postural control and compensatory strategies employed by SCI patients\, such as delayed responses and high lateral deviations\, with potential consequences for rehabilitation. This was the first study investigating the StartReact responses in trunk muscles in SCI. The SAS significantly shortened the RespT in tSCI\, but not in cSCI\, which suggests an increased cortical control in cSCI.\n\nIn the second part of the thesis\, we present mHealth tools for monitoring sleep disorders and investigate the sleep patterns of SCI patients. In the first article of this part\, we designed a smartphone system and novel algorithms based on acoustic analysis for OSA screening. This approach demonstrated good agreement with a commercial system for home OSA diagnosis\, correctly detecting and stratifying all the OSA patients. In the last article\, sleep studies were performed in SCI patients using the smartphone\, showing a very high prevalence of moderate-to-severe SDB in SCI patients. This study highlighted the problem of SDB in SCI and provided simple cost-effective tools to improve the detection and management of SDB in SCI patients.\nOverall\, this thesis supports the use of smartphones and biomedical signal analysis for the assessment of trunk function and SDB in SCI patients. These novel approaches provide quantitative and objective measures for the evaluation and follow-up of patients in a simple and non-invasive way. We also give insights into the underlying mechanisms of postural control\, respiratory function during sleep\, and the changes occurring after SCI. Consequently\, our results open the way for improving the management of health complications associated with SCI or other disabling conditions. \n\n\n\n\n\nThis thesis defence will take place at: Sala d’Actes de l’Escola d’Enginyeria Barcelona Est (EEBE)\, Edifici A\, planta 0\, Campus Diagonal-Besòs de la UPC\, Av. d’Eduard Maristany\, 16\, 08019 Barcelona. \nIf you wish to follow this defence online\, you can do it through this link: meet.google.com/roe-omfr-sse
URL:https://ibecbarcelona.eu/event/biomedical-signal-interpretation-and-smartphone-sensors-for-the-assessment-of-trunk-function-and-sleep-disorders-in-patients-with-spinal-cord-injury/
LOCATION:Sala d’Actes EEBE\, Edifici A\,\, Av. Eduard Maristany 16\, 08019 Barcelona
CATEGORIES:PhD Thesis Defence
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