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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191114T183000
DTEND;TZID=Europe/Madrid:20191114T193000
DTSTAMP:20260403T211212
CREATED:20191107T155216Z
LAST-MODIFIED:20191107T155401Z
UID:69094-1573756200-1573759800@ibecbarcelona.eu
SUMMARY:Què són els òrgans en un xip?  I la Bioenginyeria?
DESCRIPTION:Per al desenvolupament de nous fàrmacs\, la indústria depèn en gran manera de l’estudi amb models animals i amb cultius cel·lulars en 2D. Descobreix com la recerca innovadora en el desenvolupament d’òrgans en un xip pot contribuir a disminuir l’ús d’animals de laboratori i a millorar els estudis desenvolupant models en 3D. \nAmb la campanya de captació de fons del projecte Faster Future de l’IBEC\, i gràcies a persones com tu\, hem fet possible un dispositiu de múscul en un xip que permetrà provar fàrmacs al laboratori de forma fiable i econòmica. \nVine i descobreix en quina fase es troba el projecte i\, com gràcies a les aportacions econòmiques d’empreses i particulars\, hem pogut avançar una mica més cap a la medicina del futur. \nT’esperem a l’IBEC on podràs veure de primera mà aquest dispositiu i visitaràs el laboratori on s’ha desenvolupat la major part d’aquest projecte. \nApunta’t aquí
URL:https://ibecbarcelona.eu/event/que-son-els-organs-en-un-xip-i-la-bioenginyeria/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191114T183000
DTEND;TZID=Europe/Madrid:20191114T193000
DTSTAMP:20260403T211212
CREATED:20191107T155232Z
LAST-MODIFIED:20191107T155232Z
UID:96533-1573756200-1573759800@ibecbarcelona.eu
SUMMARY:Què són els òrgans en un xip?  I la Bioenginyeria?
DESCRIPTION:Per al desenvolupament de nous fàrmacs\, la indústria depèn en gran manera de l’estudi amb models animals i amb cultius cel·lulars en 2D. Descobreix com la recerca innovadora en el desenvolupament d’òrgans en un xip pot contribuir a disminuir l’ús d’animals de laboratori i a millorar els estudis desenvolupant models en 3D. \nAmb la campanya de captació de fons del projecte Faster Future de l’IBEC\, i gràcies a persones com tu\, hem fet possible un dispositiu de múscul en un xip que permetrà provar fàrmacs al laboratori de forma fiable i econòmica. \nVine i descobreix en quina fase es troba el projecte i\, com gràcies a les aportacions econòmiques d’empreses i particulars\, hem pogut avançar una mica més cap a la medicina del futur. \nT’esperem a l’IBEC on podràs veure de primera mà aquest dispositiu i visitaràs el laboratori on s’ha desenvolupat la major part d’aquest projecte. \nApunta’t aquí
URL:https://ibecbarcelona.eu/event/que-son-els-organs-en-un-xip-i-la-bioenginyeria-2/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T211212
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T154047Z
UID:69125-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T211212
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96538-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T211212
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96539-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:IBEC Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquium\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T211212
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96541-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T211212
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T094956Z
UID:69228-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T211212
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96547-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T211212
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96550-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T211212
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96551-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T211212
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96552-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T211212
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96554-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T211212
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96557-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T211212
CREATED:20191118T093609Z
LAST-MODIFIED:20191119T141506Z
UID:69274-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T211212
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:96558-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T211212
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:96559-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T211212
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:96561-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T211212
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:69646-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260403T211212
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121521Z
UID:96563-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli-2/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260403T211212
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121521Z
UID:96565-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli-3/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260403T211212
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121600Z
UID:69696-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260403T211212
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121521Z
UID:96564-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli-3/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191213T003000
DTEND;TZID=Europe/Madrid:20191213T140000
DTSTAMP:20260403T211212
CREATED:20191203T100159Z
LAST-MODIFIED:20191203T100159Z
UID:96569-1576197000-1576245600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Maria Arista
DESCRIPTION:Super-resolution microscopy as a powerful tool for understanding the formation and inhibition of influenza virus structures in mammalian cells\nMaria Arista\, Nanoscopy for Nanomedicine\nSuper-resolution microscopy is a mighty tool that has the ability to study fluorescence samples beyond the diffraction limit\, achieving a spatial resolution around 20 nm. The study of viruses can greatly benefit from super-resolution imaging\, mainly due to their small size\, between 50 and 200 nm. Here we show that\, thanks to this technique\, we are able to visualize and study two relevant viral structures: filaments of influenza virus using stochastic optical construction microscopy (STORM) and virus-like particles formed from influenza using DNAPAINT (Points accumulation for imaging in nanoscale topography) .\nInfluenza A virus is highly pleomorphic\, and virions can have either spherical or filamentous morphology. Influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long and thin filaments on the surface of infected cells\, led mainly by the matrix protein M1 and the membrane protein M2. These filaments are strongly related to the infectivity of influenza and cell-to-cell communication\, however\, due to the small size of these filaments (200 nm of width)\, they are hard to characterize in detail using immunofluorescence microscopy. \nHere\, we show with super-resolution microscopy that filament formation was inhibited by the treatment of cells with specific IgG2a and IgG1 antibodies but was not inhibited with the isotype control antibodies. Our results demonstrate that M2e-specific IgGs reduces the level influenza A virus replication in vitro and suggest that the inhibition of virus replication lead by M2especific antibodies is due to the fragmentation of filamentous virions and the loss of filament formation from the surfaces of infected cells.\nMoreover\, we study virus-like particles produced from influenza proteins transfected on mammalian cells. These structures mimic viruses but they lack viral genetic material\, for this reason they are great models to study influenza particles without risks. Influenza expresses 3 different proteins on the surface of the particle and the distribution and homogeneity between particles is not well understood. To study this distribution\, we are analyzing with DNA-PAINT the differential expression and distribution of these 3 proteins on the surface of the particles. Overall we show how super-resolution is suitable to study nanoscale viral structures and can provide new insights into anti-viral therapies. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-maria-arista-and-xarxa-quiroga-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191213T003000
DTEND;TZID=Europe/Madrid:20191213T140000
DTSTAMP:20260403T211212
CREATED:20191203T100159Z
LAST-MODIFIED:20191203T100159Z
UID:96571-1576197000-1576245600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Maria Arista
DESCRIPTION:Super-resolution microscopy as a powerful tool for understanding the formation and inhibition of influenza virus structures in mammalian cells\nMaria Arista\, Nanoscopy for Nanomedicine\nSuper-resolution microscopy is a mighty tool that has the ability to study fluorescence samples beyond the diffraction limit\, achieving a spatial resolution around 20 nm. The study of viruses can greatly benefit from super-resolution imaging\, mainly due to their small size\, between 50 and 200 nm. Here we show that\, thanks to this technique\, we are able to visualize and study two relevant viral structures: filaments of influenza virus using stochastic optical construction microscopy (STORM) and virus-like particles formed from influenza using DNAPAINT (Points accumulation for imaging in nanoscale topography) .\nInfluenza A virus is highly pleomorphic\, and virions can have either spherical or filamentous morphology. Influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long and thin filaments on the surface of infected cells\, led mainly by the matrix protein M1 and the membrane protein M2. These filaments are strongly related to the infectivity of influenza and cell-to-cell communication\, however\, due to the small size of these filaments (200 nm of width)\, they are hard to characterize in detail using immunofluorescence microscopy. \nHere\, we show with super-resolution microscopy that filament formation was inhibited by the treatment of cells with specific IgG2a and IgG1 antibodies but was not inhibited with the isotype control antibodies. Our results demonstrate that M2e-specific IgGs reduces the level influenza A virus replication in vitro and suggest that the inhibition of virus replication lead by M2especific antibodies is due to the fragmentation of filamentous virions and the loss of filament formation from the surfaces of infected cells.\nMoreover\, we study virus-like particles produced from influenza proteins transfected on mammalian cells. These structures mimic viruses but they lack viral genetic material\, for this reason they are great models to study influenza particles without risks. Influenza expresses 3 different proteins on the surface of the particle and the distribution and homogeneity between particles is not well understood. To study this distribution\, we are analyzing with DNA-PAINT the differential expression and distribution of these 3 proteins on the surface of the particles. Overall we show how super-resolution is suitable to study nanoscale viral structures and can provide new insights into anti-viral therapies. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-maria-arista-and-xarxa-quiroga-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191213T003000
DTEND;TZID=Europe/Madrid:20191213T140000
DTSTAMP:20260403T211212
CREATED:20191203T100159Z
LAST-MODIFIED:20191210T093127Z
UID:69736-1576197000-1576245600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Maria Arista
DESCRIPTION:Super-resolution microscopy for understanding the formation and inhibition of influenza virus structures\nMaria Arista\, Nanoscopy for Nanomedicine\nSuper-resolution microscopy is a mighty tool that has the ability to study fluorescence samples beyond the diffraction limit\, achieving a spatial resolution around 20 nm. The study of viruses can greatly benefit from super-resolution imaging\, mainly due to their small size\, between 50 and 200 nm. Here we show that\, thanks to this technique\, we are able to visualize and study two relevant viral structures: filaments of influenza virus using stochastic optical construction microscopy (STORM) and virus-like particles formed from influenza using DNAPAINT (Points accumulation for imaging in nanoscale topography) .\nInfluenza A virus is highly pleomorphic\, and virions can have either spherical or filamentous morphology. Influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long and thin filaments on the surface of infected cells\, led mainly by the matrix protein M1 and the membrane protein M2. These filaments are strongly related to the infectivity of influenza and cell-to-cell communication\, however\, due to the small size of these filaments (200 nm of width)\, they are hard to characterize in detail using immunofluorescence microscopy. \nHere\, we show with super-resolution microscopy that filament formation was inhibited by the treatment of cells with specific IgG2a and IgG1 antibodies but was not inhibited with the isotype control antibodies. Our results demonstrate that M2e-specific IgGs reduces the level influenza A virus replication in vitro and suggest that the inhibition of virus replication lead by M2especific antibodies is due to the fragmentation of filamentous virions and the loss of filament formation from the surfaces of infected cells.\nMoreover\, we study virus-like particles produced from influenza proteins transfected on mammalian cells. These structures mimic viruses but they lack viral genetic material\, for this reason they are great models to study influenza particles without risks. Influenza expresses 3 different proteins on the surface of the particle and the distribution and homogeneity between particles is not well understood. To study this distribution\, we are analyzing with DNA-PAINT the differential expression and distribution of these 3 proteins on the surface of the particles. Overall we show how super-resolution is suitable to study nanoscale viral structures and can provide new insights into anti-viral therapies. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-maria-arista-and-xarxa-quiroga/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191213T003000
DTEND;TZID=Europe/Madrid:20191213T140000
DTSTAMP:20260403T211212
CREATED:20191203T100159Z
LAST-MODIFIED:20191203T100159Z
UID:96567-1576197000-1576245600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Maria Arista
DESCRIPTION:Super-resolution microscopy for understanding the formation and inhibition of influenza virus structures\nMaria Arista\, Nanoscopy for Nanomedicine\nSuper-resolution microscopy is a mighty tool that has the ability to study fluorescence samples beyond the diffraction limit\, achieving a spatial resolution around 20 nm. The study of viruses can greatly benefit from super-resolution imaging\, mainly due to their small size\, between 50 and 200 nm. Here we show that\, thanks to this technique\, we are able to visualize and study two relevant viral structures: filaments of influenza virus using stochastic optical construction microscopy (STORM) and virus-like particles formed from influenza using DNAPAINT (Points accumulation for imaging in nanoscale topography) .\nInfluenza A virus is highly pleomorphic\, and virions can have either spherical or filamentous morphology. Influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long and thin filaments on the surface of infected cells\, led mainly by the matrix protein M1 and the membrane protein M2. These filaments are strongly related to the infectivity of influenza and cell-to-cell communication\, however\, due to the small size of these filaments (200 nm of width)\, they are hard to characterize in detail using immunofluorescence microscopy. \nHere\, we show with super-resolution microscopy that filament formation was inhibited by the treatment of cells with specific IgG2a and IgG1 antibodies but was not inhibited with the isotype control antibodies. Our results demonstrate that M2e-specific IgGs reduces the level influenza A virus replication in vitro and suggest that the inhibition of virus replication lead by M2especific antibodies is due to the fragmentation of filamentous virions and the loss of filament formation from the surfaces of infected cells.\nMoreover\, we study virus-like particles produced from influenza proteins transfected on mammalian cells. These structures mimic viruses but they lack viral genetic material\, for this reason they are great models to study influenza particles without risks. Influenza expresses 3 different proteins on the surface of the particle and the distribution and homogeneity between particles is not well understood. To study this distribution\, we are analyzing with DNA-PAINT the differential expression and distribution of these 3 proteins on the surface of the particles. Overall we show how super-resolution is suitable to study nanoscale viral structures and can provide new insights into anti-viral therapies. \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-maria-arista-and-xarxa-quiroga-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191219T180000
DTEND;TZID=Europe/Madrid:20191219T180000
DTSTAMP:20260403T211212
CREATED:20191212T160639Z
LAST-MODIFIED:20191212T160639Z
UID:96575-1576778400-1576778400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Celebration 2019
DESCRIPTION:We’re delighted to invite you once again to the best IBEC Christmas Party Ever!\n\nThursday 19th December · Fifteen Restaurant\, PCB\nAs usual\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season. We’re counting on you to make the party go with a swing! \n18:00 – 20:00 Team building activity\n20:00 – 21:30 Sale of raffle tickets\n20:00 – 22:00 Buffet dinner\n22:00 Raffle and party\n00:30 End\nPlease register before 16th December here
URL:https://ibecbarcelona.eu/event/ibec-christmas-celebration-2019-3/
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191219T180000
DTEND;TZID=Europe/Madrid:20191219T180000
DTSTAMP:20260403T211212
CREATED:20191212T160639Z
LAST-MODIFIED:20191212T160639Z
UID:96578-1576778400-1576778400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Celebration 2019
DESCRIPTION:We’re delighted to invite you once again to the best IBEC Christmas Party Ever!\n\nThursday 19th December · Fifteen Restaurant\, PCB\nAs usual\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season. We’re counting on you to make the party go with a swing! \n18:00 – 20:00 Team building activity\n20:00 – 21:30 Sale of raffle tickets\n20:00 – 22:00 Buffet dinner\n22:00 Raffle and party\n00:30 End\n\nPlease register before 16th December here
URL:https://ibecbarcelona.eu/event/ibec-christmas-celebration-2019-3/
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191219T180000
DTEND;TZID=Europe/Madrid:20191219T180000
DTSTAMP:20260403T211212
CREATED:20191212T160639Z
LAST-MODIFIED:20191212T161322Z
UID:69861-1576778400-1576778400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Celebration 2019
DESCRIPTION:We’re delighted to invite you once again to the best IBEC Christmas Party Ever!\n\nThursday 19th December · Fifteen Restaurant\, PCB\nAs usual\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season. We’re counting on you to make the party go with a swing! \n18:00 – 20:00 Team building activity\n20:00 – 21:30 Sale of raffle tickets\n20:00 – 22:00 Buffet dinner\n22:00 Raffle and party\n00:30 End\n\nPlease register before 16th December here
URL:https://ibecbarcelona.eu/event/ibec-christmas-celebration-2019/
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191219T180000
DTEND;TZID=Europe/Madrid:20191219T180000
DTSTAMP:20260403T211212
CREATED:20191212T160639Z
LAST-MODIFIED:20191212T160639Z
UID:96573-1576778400-1576778400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Celebration 2019
DESCRIPTION:We’re delighted to invite you once again to the best IBEC Christmas Party Ever!\n\nThursday 19th December · Fifteen Restaurant\, PCB\nAs usual\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season. We’re counting on you to make the party go with a swing! \n18:00 – 20:00 Team building activity\n20:00 – 21:30 Sale of raffle tickets\n20:00 – 22:00 Buffet dinner\n22:00 Raffle and party\n00:30 End\n\nPlease register before 16th December here
URL:https://ibecbarcelona.eu/event/ibec-christmas-celebration-2019-2/
CATEGORIES:Other
END:VEVENT
END:VCALENDAR