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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170329T120000
DTEND;TZID=Europe/Madrid:20170329T130000
DTSTAMP:20260405T211649
CREATED:20170308T135727Z
LAST-MODIFIED:20170308T135727Z
UID:96007-1490788800-1490792400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aranzazu Villasante
DESCRIPTION:Cancer Engineering: Strategies to Engineer Predictable Tumor Models\nDr. Aranzazu Villasante\, Department of Biomedical Engineering\, Columbia University\, New York\nAlthough many drugs show promise in monolayer or in animal models systems\, most fail to translate in humans and this is because they lack of ability to replicate the human microenvironment in patients. In response to these limitations\, I have generated a set of predictable tissue-engineered (TE) models of cancer by using different strategies. Today\, I am going to focus on some of these approaches to engineer pediatric tumors in vitro. Firstly\, I will show a TE model of Ewing’s sarcoma (ES) within its bone niche. This particular strategy is based on engineered human bone by introducing osteoclasts in co-culture with osteoblasts in the 3-dimensional bone niche. This model mimics bone remodeling and recapitulates some of the features observed in the osteolytic process in cancer and also\, the effects of the therapeutic reagent Zoledronic acid observed in patients. The second strategy consists in designing biomaterials with the same tumor composition to mimic the biological and mechanical properties of tumors from patients. I have developed 3D porous collagen 1-hyaluronic acid scaffolds (Col1-HA scaffolds) for studies of tumor derivedexosomes\, which are known to be initiators of pre-metastatic niche formation in certain sites. Interestingly\, I found high levels of a critical mediator of ES growth and metastasis (EZH2) in exosomes isolated from both patients and TE model of ES. Alternatively\, we cultured TE models based on Col1-HA scaffolds into a mechanical loading bioreactor for better mimicking biomechanical forces in ES. We found that biomechanical stimuli modulate osteolytic-related proteins (i.e. RUNX2) and sensitivity to anticancer drugs\, such as Sorafenib. I will also explain the use of perfusion bioreactors and cell sheet engineering to develop a novel model of Neuroblastoma (NB) to study the effect of consolidative drugs\, such as Isotretinoin\, on tumor vasculature and stem-like cells. Here\, I will show the existence of sub-populations of NB cells with different levels of stemness properties; these levels are related to the capacity of stem-like cells to transdifferentiate and also\, to chemoresistance and relapse. Finally\, the take-home message of my talk will be that TE models can bridge the gap between 2D in vitro cultures and in vivo animal models in a predictive\, inexpensive and low timeconsuming fashion for successfully understand cancer biology and improve cancer treatments.
URL:https://ibecbarcelona.eu/event/ibec-seminar-aranzazu-villasante-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170318T110000
DTEND;TZID=Europe/Madrid:20170318T170000
DTSTAMP:20260405T211649
CREATED:20170315T095240Z
LAST-MODIFIED:20170315T095240Z
UID:28168-1489834800-1489856400@ibecbarcelona.eu
SUMMARY:IV IBEC Calçotada
DESCRIPTION:IV IBEC Calçotada\nAt “Merendero Font de les Planes”\, a picnic area where you can arrive by public transport: FGC station “Les Planes” (aprox. 20min from Barcelona). \nOrganized by the IBEC PhD Committee.
URL:https://ibecbarcelona.eu/event/iv-ibec-calcotada/
LOCATION:Merendero Font de les Planes
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170318T110000
DTEND;TZID=Europe/Madrid:20170318T170000
DTSTAMP:20260405T211649
CREATED:20170315T095240Z
LAST-MODIFIED:20170315T095240Z
UID:96008-1489834800-1489856400@ibecbarcelona.eu
SUMMARY:IV IBEC Calçotada
DESCRIPTION:IV IBEC Calçotada\nAt “Merendero Font de les Planes”\, a picnic area where you can arrive by public transport: FGC station “Les Planes” (aprox. 20min from Barcelona). \nOrganized by the IBEC PhD Committee.
URL:https://ibecbarcelona.eu/event/iv-ibec-calcotada-2/
LOCATION:Merendero Font de les Planes
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170307T090000
DTEND;TZID=Europe/Madrid:20170308T170000
DTSTAMP:20260405T211649
CREATED:20170301T084527Z
LAST-MODIFIED:20170301T084527Z
UID:27938-1488877200-1488992400@ibecbarcelona.eu
SUMMARY:X Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica
DESCRIPTION:Los próximos días 7 y 8 de marzo\, se celebrará en Madrid\, la X Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica: Medicamentos Innovadores\, Nanomedicina\, Tecnología Sanitaria y Mercados Biotecnológicos. \nEn la Conferencia\, se van a abordar diferentes aspectos de la Innovación en el Sistema Nacional de Salud\, desde una perspectiva nacional e internacional de colaboración público-privada\, que permita a los pacientes el acceso a los nuevos fármacos\, incorporar la medicina personalizada y las nuevas tecnologías en el tratamiento de sus enfermedades\, y de este modo\, contribuir a la sostenibilidad del SNS. \nProgramme
URL:https://ibecbarcelona.eu/event/x-conferencia-anual-de-las-plataformas-tecnologicas-de-investigacion-biomedica/
LOCATION:Hotel Meliá Avenida de América\, C/Juan Ignacio Luca de Tena\, 36\, Madrid\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170307T090000
DTEND;TZID=Europe/Madrid:20170308T170000
DTSTAMP:20260405T211649
CREATED:20170301T084527Z
LAST-MODIFIED:20170301T084527Z
UID:96006-1488877200-1488992400@ibecbarcelona.eu
SUMMARY:X Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica
DESCRIPTION:Los próximos días 7 y 8 de marzo\, se celebrará en Madrid\, la X Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica: Medicamentos Innovadores\, Nanomedicina\, Tecnología Sanitaria y Mercados Biotecnológicos. \nEn la Conferencia\, se van a abordar diferentes aspectos de la Innovación en el Sistema Nacional de Salud\, desde una perspectiva nacional e internacional de colaboración público-privada\, que permita a los pacientes el acceso a los nuevos fármacos\, incorporar la medicina personalizada y las nuevas tecnologías en el tratamiento de sus enfermedades\, y de este modo\, contribuir a la sostenibilidad del SNS. \nProgramme
URL:https://ibecbarcelona.eu/event/x-conferencia-anual-de-las-plataformas-tecnologicas-de-investigacion-biomedica-2/
LOCATION:Hotel Meliá Avenida de América\, C/Juan Ignacio Luca de Tena\, 36\, Madrid\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170306T120000
DTEND;TZID=Europe/Madrid:20170306T130000
DTSTAMP:20260405T211649
CREATED:20170222T083846Z
LAST-MODIFIED:20170303T081702Z
UID:27719-1488801600-1488805200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Cahen
DESCRIPTION:Electron Transport across Peptides and Proteins\nProf. David Cahen\, Weizmann Institute of Science\nElectron transport (ETp)\, i.e.\, electronic conduction across peptides and proteins in a solid state–like configuration is surprisingly efficient\, and comparable to\, or at times even more efficient than via completely conjugated molecules of comparable length. Working with modified proteins and with homopeptides we find both cofactors and secondary structure to matter for ETp efficiency. An open question is if contact to the external world is the dominant factor\, or intra-protein transport. This is important\, also for electron transfer\, ET: nature regulates ET via redox chemistry\, i.e.\, injection and extraction of electrons; this is where ET and ETp are related\, because the analog in the latter is the coupling to the electrodes. In ET control over the process is achieved at the free energy price of a redox event\, but no redox process is required for ETp. This allows studying ETp via non-redox proteins\, such as rhodopsins or albumins (“dopable” proteins)\, pointing to peptides as efficient transport media; studying transport via\, including coupling to them\, can help to learn about protein ETp.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-cahen/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170306T120000
DTEND;TZID=Europe/Madrid:20170306T130000
DTSTAMP:20260405T211649
CREATED:20170222T083846Z
LAST-MODIFIED:20170222T083846Z
UID:96001-1488801600-1488805200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Cahen
DESCRIPTION:Electron Transport across Peptides and Proteins\nProf. David Cahen\, Weizmann Institute of Science\nElectron transport (ETp)\, i.e.\, electronic conduction across peptides and proteins in a solid state–like configuration is surprisingly efficient\, and comparable to\, or at times even more efficient than via completely conjugated molecules of comparable length. Working with modified proteins and with homopeptides we find both cofactors and secondary structure to matter for ETp efficiency. An open question is if contact to the external world is the dominant factor\, or intra-protein transport. This is important\, also for electron transfer\, ET: nature regulates ET via redox chemistry\, i.e.\, injection and extraction of electrons; this is where ET and ETp are related\, because the analog in the latter is the coupling to the electrodes. In ET control over the process is achieved at the free energy price of a redox event\, but no redox process is required for ETp. This allows studying ETp via non-redox proteins\, such as rhodopsins or albumins (“dopable” proteins)\, pointing to peptides as efficient transport media; studying transport via\, including coupling to them\, can help to learn about protein ETp.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-cahen-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170306T120000
DTEND;TZID=Europe/Madrid:20170306T130000
DTSTAMP:20260405T211649
CREATED:20170222T083846Z
LAST-MODIFIED:20170222T083846Z
UID:96002-1488801600-1488805200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Cahen
DESCRIPTION:Electron Transport across Peptides and Proteins\nProf. David Cahen\, Weizmann Institute of Science\nElectron transport (ETp)\, i.e.\, electronic conduction across peptides and proteins in a solid state–like configuration is surprisingly efficient\, and comparable to\, or at times even more efficient than via completely conjugated molecules of comparable length. Working with modified proteins and with homopeptides we find both cofactors and secondary structure to matter for ETp efficiency. An open question is if contact to the external world is the dominant factor\, or intra-protein transport. This is important\, also for electron transfer\, ET: nature regulates ET via redox chemistry\, i.e.\, injection and extraction of electrons; this is where ET and ETp are related\, because the analog in the latter is the coupling to the electrodes. In ET control over the process is achieved at the free energy price of a redox event\, but no redox process is required for ETp. This allows studying ETp via non-redox proteins\, such as rhodopsins or albumins (“dopable” proteins)\, pointing to peptides as efficient transport media; studying transport via\, including coupling to them\, can help to learn about protein ETp.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-cahen-3/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170306T120000
DTEND;TZID=Europe/Madrid:20170306T130000
DTSTAMP:20260405T211649
CREATED:20170222T083846Z
LAST-MODIFIED:20170222T083846Z
UID:96003-1488801600-1488805200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Cahen
DESCRIPTION:Electron Transport across Peptides and Proteins\nProf. David Cahen\, Weizmann Institute of Science\nElectron transport (ETp)\, i.e.\, electronic conduction across peptides and proteins in a solid state–like configuration is surprisingly efficient\, and comparable to\, or at times even more efficient than via completely conjugated molecules of comparable length. Working with modified proteins and with homopeptides we find both cofactors and secondary structure to matter for ETp efficiency. An open question is if contact to the external world is the dominant factor\, or intra-protein transport. This is important\, also for electron transfer\, ET: nature regulates ET via redox chemistry\, i.e.\, injection and extraction of electrons; this is where ET and ETp are related\, because the analog in the latter is the coupling to the electrodes. In ET control over the process is achieved at the free energy price of a redox event\, but no redox process is required for ETp. This allows studying ETp via non-redox proteins\, such as rhodopsins or albumins (“dopable” proteins)\, pointing to peptides as efficient transport media; studying transport via\, including coupling to them\, can help to learn about protein ETp.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-cahen-4/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T170000
DTEND;TZID=Europe/Madrid:20170303T220000
DTSTAMP:20260405T211649
CREATED:20170224T093010Z
LAST-MODIFIED:20170224T093010Z
UID:96004-1488560400-1488578400@ibecbarcelona.eu
SUMMARY:IBEC Lab Tour
DESCRIPTION:Do you ever wonder what kind of research other groups do at IBEC?\nIBEC’s PhD student committee is very pleased to invite you to the IBEC Lab Tour. \nIt’s an opportunity to visit other groups’ laboratories at IBEC and find out what they’re doing. All  are welcome regardless of position (undergraduate student\, master student\, PhD student\, postdoc\, technician\, etc.) \nAfter the tour\, there will be a pica-pica and more time for networking\, and then a visit to Bowling Pedralbes for some bowling\, beers and lots of fun. \nIf you want to join this activity\, please register in the Doodle at http://doodle.com/poll/35yikkawr332atik before Monday 27th of February.\n  \nMeet at the Helix Building Reception at 17h00
URL:https://ibecbarcelona.eu/event/ibec-lab-tour-2/
LOCATION:IBEC\, Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T170000
DTEND;TZID=Europe/Madrid:20170303T220000
DTSTAMP:20260405T211649
CREATED:20170224T093010Z
LAST-MODIFIED:20170224T093123Z
UID:27775-1488560400-1488578400@ibecbarcelona.eu
SUMMARY:IBEC Lab Tour
DESCRIPTION:Do you ever wonder what kind of research other groups do at IBEC?\nIBEC’s PhD student committee is very pleased to invite you to the IBEC Lab Tour. \nIt’s an opportunity to visit other groups’ laboratories at IBEC and find out what they’re doing. All  are welcome regardless of position (undergraduate student\, master student\, PhD student\, postdoc\, technician\, etc.) \nAfter the tour\, there will be a pica-pica and more time for networking\, and then a visit to Bowling Pedralbes for some bowling\, beers and lots of fun. \nIf you want to join this activity\, please register in the Doodle at http://doodle.com/poll/35yikkawr332atik before Monday 27th of February.\n  \nMeet at the Helix Building Reception at 17h00
URL:https://ibecbarcelona.eu/event/ibec-lab-tour/
LOCATION:IBEC\, Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T100000
DTEND;TZID=Europe/Madrid:20170303T110000
DTSTAMP:20260405T211649
CREATED:20170213T103423Z
LAST-MODIFIED:20170215T152756Z
UID:27594-1488535200-1488538800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Virumbrales
DESCRIPTION:“Development of microfluidic tools to reproduce and characterize the tumor microenvironment”\nMaria Virumbrales\, University of Zaragoza\nCompelling evidence over the years has demonstrated that the tumor microenvironment (TME) shapes tumor initiation\, development and response to therapy. This results in a high heterogeneity within the same cancer type\, and hinders the process of finding effective treatments.[1\,2] \nIn this context\, microfluidics has proven a worthy sum of techniques to create comprehensive and personalized cancer in vitro 3D models reproducing the TME in a more relevant fashion than traditional in vitro setups. \nMicrofluidics also permits a high degree of control over the setup\, combining different cell types in an orderly manner\, as well as different physical and biochemical cues. [3] Furthermore\, microfluidics facilitates optical inspection and diminishes sample sizes and reagent volumes needed for each experiment. Microfluidic devices are also compatible with high-throughput approaches\, which make them an interesting option for drug testing\, research and development.[4] \nHence\, we developed two microfluidic tumor models\, which we used to model and characterize different aspects of the TME. TME was characterized in terms of hypoxia\, proliferation rates\, reactive oxygen species concentration\, apoptosis rate and glucose uptake.[5] Moreover\, the influence of tumor cells on an endothelium was investigated. Furthermore\, we carried out pharmacodynamic and drug efficiency studies in these newly-established models. Thereafter\, we developed a simple enzymatic protocol to extract cells seeded in 3D from the microfluidic devices. Cells could be sorted by flow cytometry according to the expression of specific surface markers or by using different fluorescent stains. RNA was extracted for downstream quantification and gene profiling was carried out for the mentioned aspects of the tumor microenvironment. \nAll in all\, we developed two easy-to-use microfluidic models for personalized medicine capable of comprehensive reproduction of the TME\, which allows characterization of tumor signatures by means of microscopy and traditional benchtop methods. \n\nBalkwill FR\, Capasso M\, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125: 5591-5596.\nKlemm F\, Joyce JA (2015) Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol 25: 198-213.\nSackmann EK\, Fulton AL\, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507: 181-189.\nDu G\, Fang Q\, den Toonder JMJ (2016) Microfluidics for cell-based high throughput screening platforms—A review. Analytica Chimica Acta 903: 36-50.\nAyuso JM\, Virumbrales-Munoz M\, Lacueva A\, Lanuza PM\, Checa-Chavarria E\, et al. (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep 6: 36086.\n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-virumbrales/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T100000
DTEND;TZID=Europe/Madrid:20170303T110000
DTSTAMP:20260405T211649
CREATED:20170213T103423Z
LAST-MODIFIED:20170213T103423Z
UID:95997-1488535200-1488538800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Virumbrales
DESCRIPTION:“Development of microfluidic tools to reproduce and characterize the tumor microenvironment”\nMaria Virumbrales\, University of Zaragoza\nCompelling evidence over the years has demonstrated that the tumor microenvironment (TME) shapes tumor initiation\, development and response to therapy. This results in a high heterogeneity within the same cancer type\, and hinders the process of finding effective treatments.[1\,2] \nIn this context\, microfluidics has proven a worthy sum of techniques to create comprehensive and personalized cancer in vitro 3D models reproducing the TME in a more relevant fashion than traditional in vitro setups. \nMicrofluidics also permits a high degree of control over the setup\, combining different cell types in an orderly manner\, as well as different physical and biochemical cues. [3] Furthermore\, microfluidics facilitates optical inspection and diminishes sample sizes and reagent volumes needed for each experiment. Microfluidic devices are also compatible with high-throughput approaches\, which make them an interesting option for drug testing\, research and development.[4] \nHence\, we developed two microfluidic tumor models\, which we used to model and characterize different aspects of the TME. TME was characterized in terms of hypoxia\, proliferation rates\, reactive oxygen species concentration\, apoptosis rate and glucose uptake.[5] Moreover\, the influence of tumor cells on an endothelium was investigated. Furthermore\, we carried out pharmacodynamic and drug efficiency studies in these newly-established models. Thereafter\, we developed a simple enzymatic protocol to extract cells seeded in 3D from the microfluidic devices. Cells could be sorted by flow cytometry according to the expression of specific surface markers or by using different fluorescent stains. RNA was extracted for downstream quantification and gene profiling was carried out for the mentioned aspects of the tumor microenvironment. \nAll in all\, we developed two easy-to-use microfluidic models for personalized medicine capable of comprehensive reproduction of the TME\, which allows characterization of tumor signatures by means of microscopy and traditional benchtop methods. \n\nBalkwill FR\, Capasso M\, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125: 5591-5596.\nKlemm F\, Joyce JA (2015) Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol 25: 198-213.\nSackmann EK\, Fulton AL\, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507: 181-189.\nDu G\, Fang Q\, den Toonder JMJ (2016) Microfluidics for cell-based high throughput screening platforms—A review. Analytica Chimica Acta 903: 36-50.\nAyuso JM\, Virumbrales-Munoz M\, Lacueva A\, Lanuza PM\, Checa-Chavarria E\, et al. (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep 6: 36086.\n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-virumbrales-4/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T100000
DTEND;TZID=Europe/Madrid:20170303T110000
DTSTAMP:20260405T211649
CREATED:20170213T103423Z
LAST-MODIFIED:20170213T103423Z
UID:95991-1488535200-1488538800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Virumbrales
DESCRIPTION:“Development of microfluidic tools to reproduce and characterize the tumor microenvironment”\nMaria Virumbrales\, University of Zaragoza\nCompelling evidence over the years has demonstrated that the tumor microenvironment (TME) shapes tumor initiation\, development and response to therapy. This results in a high heterogeneity within the same cancer type\, and hinders the process of finding effective treatments.[1\,2] \nIn this context\, microfluidics has proven a worthy sum of techniques to create comprehensive and personalized cancer in vitro 3D models reproducing the TME in a more relevant fashion than traditional in vitro setups. \nMicrofluidics also permits a high degree of control over the setup\, combining different cell types in an orderly manner\, as well as different physical and biochemical cues. [3] Furthermore\, microfluidics facilitates optical inspection and diminishes sample sizes and reagent volumes needed for each experiment. Microfluidic devices are also compatible with high-throughput approaches\, which make them an interesting option for drug testing\, research and development.[4] \nHence\, we developed two microfluidic tumor models\, which we used to model and characterize different aspects of the TME. TME was characterized in terms of hypoxia\, proliferation rates\, reactive oxygen species concentration\, apoptosis rate and glucose uptake.[5] Moreover\, the influence of tumor cells on an endothelium was investigated. Furthermore\, we carried out pharmacodynamic and drug efficiency studies in these newly-established models. Thereafter\, we developed a simple enzymatic protocol to extract cells seeded in 3D from the microfluidic devices. Cells could be sorted by flow cytometry according to the expression of specific surface markers or by using different fluorescent stains. RNA was extracted for downstream quantification and gene profiling was carried out for the mentioned aspects of the tumor microenvironment. \nAll in all\, we developed two easy-to-use microfluidic models for personalized medicine capable of comprehensive reproduction of the TME\, which allows characterization of tumor signatures by means of microscopy and traditional benchtop methods. \n\nBalkwill FR\, Capasso M\, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125: 5591-5596.\nKlemm F\, Joyce JA (2015) Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol 25: 198-213.\nSackmann EK\, Fulton AL\, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507: 181-189.\nDu G\, Fang Q\, den Toonder JMJ (2016) Microfluidics for cell-based high throughput screening platforms—A review. Analytica Chimica Acta 903: 36-50.\nAyuso JM\, Virumbrales-Munoz M\, Lacueva A\, Lanuza PM\, Checa-Chavarria E\, et al. (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep 6: 36086.\n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-virumbrales-3/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T100000
DTEND;TZID=Europe/Madrid:20170303T110000
DTSTAMP:20260405T211649
CREATED:20170213T103423Z
LAST-MODIFIED:20170213T103423Z
UID:95988-1488535200-1488538800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Virumbrales
DESCRIPTION:“Development of microfluidic tools to reproduce and characterize the tumor microenvironment”\nMaria Virumbrales\, University of Zaragoza\nCompelling evidence over the years has demonstrated that the tumor microenvironment (TME) shapes tumor initiation\, development and response to therapy. This results in a high heterogeneity within the same cancer type\, and hinders the process of finding effective treatments.[1\,2] \nIn this context\, microfluidics has proven a worthy sum of techniques to create comprehensive and personalized cancer in vitro 3D models reproducing the TME in a more relevant fashion than traditional in vitro setups. \nMicrofluidics also permits a high degree of control over the setup\, combining different cell types in an orderly manner\, as well as different physical and biochemical cues. [3] Furthermore\, microfluidics facilitates optical inspection and diminishes sample sizes and reagent volumes needed for each experiment. Microfluidic devices are also compatible with high-throughput approaches\, which make them an interesting option for drug testing\, research and development.[4] \nHence\, we developed two microfluidic tumor models\, which we used to model and characterize different aspects of the TME. TME was characterized in terms of hypoxia\, proliferation rates\, reactive oxygen species concentration\, apoptosis rate and glucose uptake.[5] Moreover\, the influence of tumor cells on an endothelium was investigated. Furthermore\, we carried out pharmacodynamic and drug efficiency studies in these newly-established models. Thereafter\, we developed a simple enzymatic protocol to extract cells seeded in 3D from the microfluidic devices. Cells could be sorted by flow cytometry according to the expression of specific surface markers or by using different fluorescent stains. RNA was extracted for downstream quantification and gene profiling was carried out for the mentioned aspects of the tumor microenvironment. \nAll in all\, we developed two easy-to-use microfluidic models for personalized medicine capable of comprehensive reproduction of the TME\, which allows characterization of tumor signatures by means of microscopy and traditional benchtop methods. \n\nBalkwill FR\, Capasso M\, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125: 5591-5596.\nKlemm F\, Joyce JA (2015) Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol 25: 198-213.\nSackmann EK\, Fulton AL\, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507: 181-189.\nDu G\, Fang Q\, den Toonder JMJ (2016) Microfluidics for cell-based high throughput screening platforms—A review. Analytica Chimica Acta 903: 36-50.\nAyuso JM\, Virumbrales-Munoz M\, Lacueva A\, Lanuza PM\, Checa-Chavarria E\, et al. (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep 6: 36086.\n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-virumbrales-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170228T100000
DTEND;TZID=Europe/Madrid:20170228T111500
DTSTAMP:20260405T211649
CREATED:20161212T091120Z
LAST-MODIFIED:20161212T091120Z
UID:95968-1488276000-1488280500@ibecbarcelona.eu
SUMMARY:Matins de recerca: Elisabeth Engel
DESCRIPTION:Matins de recerca\nA series of morning talks about current research\, held at CosmoCaixa and given by researchers from the institutions and universities. \nScience and technology are presented with the aim of encouraging young people into the world of scientific discovery in an accessible\, engaging format. \n— \nLa regeneració d’òrgans com a paradigma de la medicina del futur \nEn el passat\, la idea d’un home biònic ha estat només cosa de la ficció. Però actualment no sembla tan increïble que la tecnologia pugui igualar les capacitats del cos humà. Els investigadors de l’IBEC s’estan enfrontant a un ampli ventall de reptes en enginyeria de teixits. \n  \nDr. Elisabeth Engel \, Head of IBEC’s Biomaterials for Regenerative Therapies group\n \nMore details here.
URL:https://ibecbarcelona.eu/event/matins-de-recerca-elisabeth-engel-3/
LOCATION:CosmoCaixa Barcelona\, Carrer d'Isaac Newton\, 08022 Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170228T100000
DTEND;TZID=Europe/Madrid:20170228T111500
DTSTAMP:20260405T211649
CREATED:20161212T091120Z
LAST-MODIFIED:20161212T091120Z
UID:95969-1488276000-1488280500@ibecbarcelona.eu
SUMMARY:Matins de recerca: Elisabeth Engel
DESCRIPTION:Matins de recerca\nA series of morning talks about current research\, held at CosmoCaixa and given by researchers from the institutions and universities. \nScience and technology are presented with the aim of encouraging young people into the world of scientific discovery in an accessible\, engaging format. \n— \nLa regeneració d’òrgans com a paradigma de la medicina del futur \nEn el passat\, la idea d’un home biònic ha estat només cosa de la ficció. Però actualment no sembla tan increïble que la tecnologia pugui igualar les capacitats del cos humà. Els investigadors de l’IBEC s’estan enfrontant a un ampli ventall de reptes en enginyeria de teixits. \n  \nDr. Elisabeth Engel \, Head of IBEC’s Biomaterials for Regenerative Therapies group\n \nMore details here.
URL:https://ibecbarcelona.eu/event/matins-de-recerca-elisabeth-engel-4/
LOCATION:CosmoCaixa Barcelona\, Carrer d'Isaac Newton\, 08022 Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170228T100000
DTEND;TZID=Europe/Madrid:20170228T111500
DTSTAMP:20260405T211649
CREATED:20161212T091120Z
LAST-MODIFIED:20170801T105316Z
UID:26402-1488276000-1488280500@ibecbarcelona.eu
SUMMARY:Matins de recerca: Elisabeth Engel
DESCRIPTION:Matins de recerca\nA series of morning talks about current research\, held at CosmoCaixa and given by researchers from the institutions and universities. \nScience and technology are presented with the aim of encouraging young people into the world of scientific discovery in an accessible\, engaging format. \n— \nLa regeneració d’òrgans com a paradigma de la medicina del futur \nEn el passat\, la idea d’un home biònic ha estat només cosa de la ficció. Però actualment no sembla tan increïble que la tecnologia pugui igualar les capacitats del cos humà. Els investigadors de l’IBEC s’estan enfrontant a un ampli ventall de reptes en enginyeria de teixits. \n  \nDr. Elisabeth Engel \, Head of IBEC’s Biomaterials for Regenerative Therapies group\n \nMore details here.
URL:https://ibecbarcelona.eu/event/matins-de-recerca-elisabeth-engel/
LOCATION:CosmoCaixa Barcelona\, Carrer d'Isaac Newton\, 08022 Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170228T100000
DTEND;TZID=Europe/Madrid:20170228T111500
DTSTAMP:20260405T211649
CREATED:20161212T091120Z
LAST-MODIFIED:20161212T091120Z
UID:95962-1488276000-1488280500@ibecbarcelona.eu
SUMMARY:Matins de recerca: Elisabeth Engel
DESCRIPTION:Matins de recerca\nA series of morning talks about current research\, held at CosmoCaixa and given by researchers from the institutions and universities. \nScience and technology are presented with the aim of encouraging young people into the world of scientific discovery in an accessible\, engaging format. \n— \nLa regeneració d’òrgans com a paradigma de la medicina del futur \nEn el passat\, la idea d’un home biònic ha estat només cosa de la ficció. Però actualment no sembla tan increïble que la tecnologia pugui igualar les capacitats del cos humà. Els investigadors de l’IBEC s’estan enfrontant a un ampli ventall de reptes en enginyeria de teixits. \n  \nDr. Elisabeth Engel \, Head of IBEC’s Biomaterials for Regenerative Therapies group\n \nMore details here.
URL:https://ibecbarcelona.eu/event/matins-de-recerca-elisabeth-engel-2/
LOCATION:CosmoCaixa Barcelona\, Carrer d'Isaac Newton\, 08022 Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170227T093000
DTEND;TZID=Europe/Madrid:20170302T163000
DTSTAMP:20260405T211649
CREATED:20170214T121749Z
LAST-MODIFIED:20170801T105201Z
UID:27632-1488187800-1488472200@ibecbarcelona.eu
SUMMARY:YoMo:
The Youth Mobile Festival
DESCRIPTION:IBEC at the Mobile World Congress\nIBEC will take part in the Youth Mobile Festival (YOMO) of the Mobile World Congress\, the world’s largest gathering for the mobile industry\, at the end of February with an interactive stand about bioengineering for cardiac regeneration. \nWith the aid of a 3D pen\, attendees will be able to replicate one of the techniques that are used for research in this area. The activity will reflect on the advantages and disadvantages of these types of therapies\, and visitors will also have the opportunity to examine some tissue samples made with IBEC’s 3D bioprinter using a microscope. \nYOMO\, with 1200 hours of live theatre shows\, interactive workshops\, and dozens of hands-on activities\, is expected to attract up to 20\,000 10-16 year olds from across Catalonia and Spain.
URL:https://ibecbarcelona.eu/event/yomo%e2%80%a8the-youth-mobile-festival/
LOCATION:Fira de Barcelona\, Montjuïc Hall 1\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170227T093000
DTEND;TZID=Europe/Madrid:20170302T163000
DTSTAMP:20260405T211649
CREATED:20170214T121749Z
LAST-MODIFIED:20170214T121749Z
UID:95994-1488187800-1488472200@ibecbarcelona.eu
SUMMARY:YoMo:
The Youth Mobile Festival
DESCRIPTION:IBEC at the Mobile World Congress\nIBEC will take part in the Youth Mobile Festival (YOMO) of the Mobile World Congress\, the world’s largest gathering for the mobile industry\, at the end of February with an interactive stand about bioengineering for cardiac regeneration. \nWith the aid of a 3D pen\, attendees will be able to replicate one of the techniques that are used for research in this area. The activity will reflect on the advantages and disadvantages of these types of therapies\, and visitors will also have the opportunity to examine some tissue samples made with IBEC’s 3D bioprinter using a microscope. \nYOMO\, with 1200 hours of live theatre shows\, interactive workshops\, and dozens of hands-on activities\, is expected to attract up to 20\,000 10-16 year olds from across Catalonia and Spain.
URL:https://ibecbarcelona.eu/event/yomo-the-youth-mobile-festival/
LOCATION:Fira de Barcelona\, Montjuïc Hall 1\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170227T093000
DTEND;TZID=Europe/Madrid:20170302T163000
DTSTAMP:20260405T211649
CREATED:20170214T121749Z
LAST-MODIFIED:20170214T121749Z
UID:95995-1488187800-1488472200@ibecbarcelona.eu
SUMMARY:YoMo:
The Youth Mobile Festival
DESCRIPTION:IBEC at the Mobile World Congress\nIBEC will take part in the Youth Mobile Festival (YOMO) of the Mobile World Congress\, the world’s largest gathering for the mobile industry\, at the end of February with an interactive stand about bioengineering for cardiac regeneration. \nWith the aid of a 3D pen\, attendees will be able to replicate one of the techniques that are used for research in this area. The activity will reflect on the advantages and disadvantages of these types of therapies\, and visitors will also have the opportunity to examine some tissue samples made with IBEC’s 3D bioprinter using a microscope. \nYOMO\, with 1200 hours of live theatre shows\, interactive workshops\, and dozens of hands-on activities\, is expected to attract up to 20\,000 10-16 year olds from across Catalonia and Spain.
URL:https://ibecbarcelona.eu/event/yomo-the-youth-mobile-festival-2/
LOCATION:Fira de Barcelona\, Montjuïc Hall 1\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170227T093000
DTEND;TZID=Europe/Madrid:20170302T163000
DTSTAMP:20260405T211649
CREATED:20170214T121749Z
LAST-MODIFIED:20170214T121749Z
UID:95996-1488187800-1488472200@ibecbarcelona.eu
SUMMARY:YoMo:
The Youth Mobile Festival
DESCRIPTION:IBEC at the Mobile World Congress\nIBEC will take part in the Youth Mobile Festival (YOMO) of the Mobile World Congress\, the world’s largest gathering for the mobile industry\, at the end of February with an interactive stand about bioengineering for cardiac regeneration. \nWith the aid of a 3D pen\, attendees will be able to replicate one of the techniques that are used for research in this area. The activity will reflect on the advantages and disadvantages of these types of therapies\, and visitors will also have the opportunity to examine some tissue samples made with IBEC’s 3D bioprinter using a microscope. \nYOMO\, with 1200 hours of live theatre shows\, interactive workshops\, and dozens of hands-on activities\, is expected to attract up to 20\,000 10-16 year olds from across Catalonia and Spain.
URL:https://ibecbarcelona.eu/event/yomo-the-youth-mobile-festival-3/
LOCATION:Fira de Barcelona\, Montjuïc Hall 1\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170224T090000
DTEND;TZID=Europe/Madrid:20170224T180000
DTSTAMP:20260405T211649
CREATED:20170214T155207Z
LAST-MODIFIED:20170801T110449Z
UID:27662-1487926800-1487959200@ibecbarcelona.eu
SUMMARY:Bioengineering Workshop - ASBTEC & IBEC
DESCRIPTION:Després de l’èxit del Workshop de Biologia Sintètica que vam organitzar des de l’ASBTEC ara fa un any\, tenim l’honor de presentar-vos un nou Workshop sobre Bioenginyeria\, organitzat conjuntament amb l’Institut de Bioenginyeria de Catalunya (IBEC). Aquest camp de les biociències s’ha posat tant de moda per la incorporació sistemàtica de noves tecnologies (especialment les d’escales microscòpiques) a la biologia clàssica per tal de tirar endavant nous projectes i possibilitats. \n\nEl dia 24 de Febrer us tenim preparat una jornada completa de presentació de la Bioenginyeria. Amb un programa completíssim i variat (ja el podeu consultar al cartell oficial)\, centrarem el Workshop en tres grans blocs: \n\nPresentació de les principals branques de la Bioenginyeria. Pentintarem\, entre d’altres\, els biomaterials\, la manipulació cel·lular\, la nanotecnologia\, així com els principals projectes catalans i europeus. Quatre investigadors pioners en els seus camps ens mostraran els grans potencials d’aquestes branques.\nIntroducció a les principals tècniques que han fet avançar la bioenginyeria: Impresora 3D\, Organ-on-a-chip i CRISPR. Descobrirem aquestes tècniques les quals tots hem sentit a parlar i seran imprescindibles en un futur ben pròxim.\nTaula rodona i discussió informal amb joves bioenginyers i bioenginyeres. Tindrem la oportunitat de sentir l’experiència i compartir un pica-pica amb diferents perfils de doctorands i doctors en bioenginyeria. Des de la microscopia o l’optogenètica\, fins la indústria mèdica\, passant per la reprogramació cel·lular.\n\nQualsevol estudiant o professional amb motivacions per la Bioenginyeria serà més que benvingut. Amb una rigurositat científica ben estricte\, aquest esdeveniment està pensat per tots els estrats de biociències (estudiants de Grau\, estudiants de Màster i professionals del sector) \nAquest Workshop serà íntegrament en anglès. \n\nLloc: Sala Dolors Aleu\, Institut de Bioenginyeria de Catalunya (IBEC)\nData: 24 de Febrer de 2017\nHorari: 09h – 18h\n\nPreu: 5€ socis d’ASBTEC o membres de l’IBEC. 20€ no socis.\n15€ inscripció + associar-se a l’ASBTEC\nRegister at http://asbtec.blogspot.com.es/
URL:https://ibecbarcelona.eu/event/bioengineering-workshop-asbtec-ibec/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170224T090000
DTEND;TZID=Europe/Madrid:20170224T180000
DTSTAMP:20260405T211649
CREATED:20170214T155207Z
LAST-MODIFIED:20170214T155207Z
UID:95998-1487926800-1487959200@ibecbarcelona.eu
SUMMARY:Bioengineering Workshop - ASBTEC & IBEC
DESCRIPTION:Després de l’èxit del Workshop de Biologia Sintètica que vam organitzar des de l’ASBTEC ara fa un any\, tenim l’honor de presentar-vos un nou Workshop sobre Bioenginyeria\, organitzat conjuntament amb l’Institut de Bioenginyeria de Catalunya (IBEC). Aquest camp de les biociències s’ha posat tant de moda per la incorporació sistemàtica de noves tecnologies (especialment les d’escales microscòpiques) a la biologia clàssica per tal de tirar endavant nous projectes i possibilitats. \n\nEl dia 24 de Febrer us tenim preparat una jornada completa de presentació de la Bioenginyeria. Amb un programa completíssim i variat (ja el podeu consultar al cartell oficial)\, centrarem el Workshop en tres grans blocs: \n\nPresentació de les principals branques de la Bioenginyeria. Pentintarem\, entre d’altres\, els biomaterials\, la manipulació cel·lular\, la nanotecnologia\, així com els principals projectes catalans i europeus. Quatre investigadors pioners en els seus camps ens mostraran els grans potencials d’aquestes branques.\nIntroducció a les principals tècniques que han fet avançar la bioenginyeria: Impresora 3D\, Organ-on-a-chip i CRISPR. Descobrirem aquestes tècniques les quals tots hem sentit a parlar i seran imprescindibles en un futur ben pròxim.\nTaula rodona i discussió informal amb joves bioenginyers i bioenginyeres. Tindrem la oportunitat de sentir l’experiència i compartir un pica-pica amb diferents perfils de doctorands i doctors en bioenginyeria. Des de la microscopia o l’optogenètica\, fins la indústria mèdica\, passant per la reprogramació cel·lular.\n\nQualsevol estudiant o professional amb motivacions per la Bioenginyeria serà més que benvingut. Amb una rigurositat científica ben estricte\, aquest esdeveniment està pensat per tots els estrats de biociències (estudiants de Grau\, estudiants de Màster i professionals del sector) \nAquest Workshop serà íntegrament en anglès. \n\nLloc: Sala Dolors Aleu\, Institut de Bioenginyeria de Catalunya (IBEC)\nData: 24 de Febrer de 2017\nHorari: 09h – 18h\n\nPreu: 5€ socis d’ASBTEC o membres de l’IBEC. 20€ no socis.\n15€ inscripció + associar-se a l’ASBTEC\nRegister at http://asbtec.blogspot.com.es/
URL:https://ibecbarcelona.eu/event/bioengineering-workshop-asbtec-ibec-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170224T090000
DTEND;TZID=Europe/Madrid:20170224T180000
DTSTAMP:20260405T211649
CREATED:20170214T155207Z
LAST-MODIFIED:20170214T155207Z
UID:95999-1487926800-1487959200@ibecbarcelona.eu
SUMMARY:Bioengineering Workshop - ASBTEC & IBEC
DESCRIPTION:Després de l’èxit del Workshop de Biologia Sintètica que vam organitzar des de l’ASBTEC ara fa un any\, tenim l’honor de presentar-vos un nou Workshop sobre Bioenginyeria\, organitzat conjuntament amb l’Institut de Bioenginyeria de Catalunya (IBEC). Aquest camp de les biociències s’ha posat tant de moda per la incorporació sistemàtica de noves tecnologies (especialment les d’escales microscòpiques) a la biologia clàssica per tal de tirar endavant nous projectes i possibilitats. \n\nEl dia 24 de Febrer us tenim preparat una jornada completa de presentació de la Bioenginyeria. Amb un programa completíssim i variat (ja el podeu consultar al cartell oficial)\, centrarem el Workshop en tres grans blocs: \n\nPresentació de les principals branques de la Bioenginyeria. Pentintarem\, entre d’altres\, els biomaterials\, la manipulació cel·lular\, la nanotecnologia\, així com els principals projectes catalans i europeus. Quatre investigadors pioners en els seus camps ens mostraran els grans potencials d’aquestes branques.\nIntroducció a les principals tècniques que han fet avançar la bioenginyeria: Impresora 3D\, Organ-on-a-chip i CRISPR. Descobrirem aquestes tècniques les quals tots hem sentit a parlar i seran imprescindibles en un futur ben pròxim.\nTaula rodona i discussió informal amb joves bioenginyers i bioenginyeres. Tindrem la oportunitat de sentir l’experiència i compartir un pica-pica amb diferents perfils de doctorands i doctors en bioenginyeria. Des de la microscopia o l’optogenètica\, fins la indústria mèdica\, passant per la reprogramació cel·lular.\n\nQualsevol estudiant o professional amb motivacions per la Bioenginyeria serà més que benvingut. Amb una rigurositat científica ben estricte\, aquest esdeveniment està pensat per tots els estrats de biociències (estudiants de Grau\, estudiants de Màster i professionals del sector) \nAquest Workshop serà íntegrament en anglès. \n\nLloc: Sala Dolors Aleu\, Institut de Bioenginyeria de Catalunya (IBEC)\nData: 24 de Febrer de 2017\nHorari: 09h – 18h\n\nPreu: 5€ socis d’ASBTEC o membres de l’IBEC. 20€ no socis.\n15€ inscripció + associar-se a l’ASBTEC\nRegister at http://asbtec.blogspot.com.es/
URL:https://ibecbarcelona.eu/event/bioengineering-workshop-asbtec-ibec-3/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170224T090000
DTEND;TZID=Europe/Madrid:20170224T180000
DTSTAMP:20260405T211649
CREATED:20170214T155207Z
LAST-MODIFIED:20170214T155207Z
UID:96000-1487926800-1487959200@ibecbarcelona.eu
SUMMARY:Bioengineering Workshop - ASBTEC & IBEC
DESCRIPTION:Després de l’èxit del Workshop de Biologia Sintètica que vam organitzar des de l’ASBTEC ara fa un any\, tenim l’honor de presentar-vos un nou Workshop sobre Bioenginyeria\, organitzat conjuntament amb l’Institut de Bioenginyeria de Catalunya (IBEC). Aquest camp de les biociències s’ha posat tant de moda per la incorporació sistemàtica de noves tecnologies (especialment les d’escales microscòpiques) a la biologia clàssica per tal de tirar endavant nous projectes i possibilitats. \n\nEl dia 24 de Febrer us tenim preparat una jornada completa de presentació de la Bioenginyeria. Amb un programa completíssim i variat (ja el podeu consultar al cartell oficial)\, centrarem el Workshop en tres grans blocs: \n\nPresentació de les principals branques de la Bioenginyeria. Pentintarem\, entre d’altres\, els biomaterials\, la manipulació cel·lular\, la nanotecnologia\, així com els principals projectes catalans i europeus. Quatre investigadors pioners en els seus camps ens mostraran els grans potencials d’aquestes branques.\nIntroducció a les principals tècniques que han fet avançar la bioenginyeria: Impresora 3D\, Organ-on-a-chip i CRISPR. Descobrirem aquestes tècniques les quals tots hem sentit a parlar i seran imprescindibles en un futur ben pròxim.\nTaula rodona i discussió informal amb joves bioenginyers i bioenginyeres. Tindrem la oportunitat de sentir l’experiència i compartir un pica-pica amb diferents perfils de doctorands i doctors en bioenginyeria. Des de la microscopia o l’optogenètica\, fins la indústria mèdica\, passant per la reprogramació cel·lular.\n\nQualsevol estudiant o professional amb motivacions per la Bioenginyeria serà més que benvingut. Amb una rigurositat científica ben estricte\, aquest esdeveniment està pensat per tots els estrats de biociències (estudiants de Grau\, estudiants de Màster i professionals del sector) \nAquest Workshop serà íntegrament en anglès. \n\nLloc: Sala Dolors Aleu\, Institut de Bioenginyeria de Catalunya (IBEC)\nData: 24 de Febrer de 2017\nHorari: 09h – 18h\n\nPreu: 5€ socis d’ASBTEC o membres de l’IBEC. 20€ no socis.\n15€ inscripció + associar-se a l’ASBTEC\nRegister at http://asbtec.blogspot.com.es/
URL:https://ibecbarcelona.eu/event/bioengineering-workshop-asbtec-ibec-4/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260405T211649
CREATED:20170213T100423Z
LAST-MODIFIED:20170213T100423Z
UID:95987-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260405T211649
CREATED:20170213T100423Z
LAST-MODIFIED:20170213T100423Z
UID:95992-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente-3/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260405T211649
CREATED:20170213T100423Z
LAST-MODIFIED:20170213T100423Z
UID:95993-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente-4/
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR