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DTSTART;TZID=Europe/Madrid:20260513T110000
DTEND;TZID=Europe/Madrid:20260513T120000
DTSTAMP:20260422T230610
CREATED:20260408T090658Z
LAST-MODIFIED:20260408T090658Z
UID:133154-1778670000-1778673600@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Assoc. Prof. Laura Alvarez
DESCRIPTION:Bioinspired soft-matter systems: engineering life-like behaviors\nAssoc. Prof. Laura Alvarez\, Associate Professor at the University of Bordeaux and leads the Soft BioColloids group at the Centre de Recherche Paul Pascal (CRPP\, CNRS) \nCells\, even in their simplest forms\, exhibit adaptive motion and task execution\, capabilities underpinned by their complex and hierarchized architecture\, and their ability to dissipate energy. Replicating such intricate behavior at the microscale offers a pathway to uncover the fundamental physical and material ingredients required for biological complexity\, while also inspiring the design of next-generation synthetic cells [1\,2]. Here\, I will demonstrate that using soft and adaptive compartments is the key to a new generation of biomimetic out-of-equilibrium systems. I will show our recent results on the fabrication of motile giant unilamellar vesicles (GUVs) driven out-of-equilibrium under external actuation. In contrast to the traditional active colloids [3\,4]\, active GUVs present an excellent cell-model system\, thanks to their membrane properties and their ability to enclose nano and micro-objects. We report on their run-and-tumble dynamics\, reminiscent of bacteria dynamic patterns\, mainly due to the intrinsic lipid membrane properties [5] We further investigate controlled deformations and division-like events under electric-fields and light as energy input. We show that these two external fields provide a programmable handle to steer out-of-equilibrium behaviors in these synthetic cells\, enabling membrane mechanics and shape transformations that mimic key features of cell division and protrusion formation. \n  \n[1] G.Volpe\, N. A. M. Araújo\, M. Guix\, M. Miodownik\, N.Martin\, L. Alvarez\, et.al.\, Animated Matter Roadmap (2025) \n[2] V. Willems\, P. Moreno\, J. Fojo\, L. Rodriguez-Arco\, L.Alvarez. Life-like processes in synthetic protocells under external fields. Newton (2026) \n[3] Alvarez\, L.\, Fernandez-Rodriguez\, M.A.\, Alegria\, A. et al. Reconfigurable artificial microswimmers with internal feedback. Nat. Commun. (2021) \n[4] van Kesteren\, S.\, Alvarez\, L Arrese-Igor\, S.\, Alegría\, A.\, Isa\, L\, Self-propelling colloidal finite state machines. PNAS (2024) \n[5] V. Willems\, A. Baron\, D. A. Matoz-Fernandez\, G. Wolfisberg\, E. Dufresne\, J. C. Baret\, and L. Alvarez. Soft Matter (2025). \n  \nDr. Laura Alvarez is an Associate Professor at the University of Bordeaux and leads the Soft BioColloids group at the Centre de Recherche Paul Pascal (CRPP\, CNRS). She completed a joint PhD between the University of Bordeaux and KU Leuven on the dynamics of colloidal liquid crystals\, followed by postdoctoral research at ETH Zurich on responsive\, light-controlled active colloidal assemblies. Her research lies at the interface of soft matter\, active matter\, and synthetic cells. She develops out-of-equilibrium bioinspired microsystems using colloids\, giant lipid vesicles\, microfluidics\, and optical or electrical actuation to study active transport\, membrane shape transformations\, and collective dynamics in minimal cell-like systems. Her work aims to understand and harness non-equilibrium processes to engineer functional\, cell-mimetic microdevices. Dr. Alvarez has also served as an ESA consultant in Soft Matter and Biophysics and is currently involved in microgravity experiments on giant lipid vesicles in collaboration with DLR through the MAPHEUS campaigns. She is an active member of the association Femmes & Sciences in France\, promoting the visibility of women in STEM and outreach in physics\, chemistry\, and space science
URL:https://ibecbarcelona.eu/event/ibec-seminar-assoc-prof-laura-alvarez/
LOCATION:Room 1\, Tower R
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260513T140000
DTEND;TZID=Europe/Madrid:20260513T150000
DTSTAMP:20260422T230610
CREATED:20260320T101141Z
LAST-MODIFIED:20260320T101141Z
UID:132912-1778680800-1778684400@ibecbarcelona.eu
SUMMARY:Ibec Seminar:  Dr Pascale Quilichini
DESCRIPTION:Neuronal infra-slow rhythm in the thalamic nucleus reuniens orchestrate hippocampo-prefrontal information flow during sleep\nDr Pascale Quilichini\, Institut de Neurosciences des Systèmes\, INSERM\, Aix-Marseille University \nThe consolidation of episodic memory during sleep relies on coordinated interactions between the hippocampus (HPC) and the prefrontal cortex (PFC)\, although these regions lack direct reciprocal connections. The thalamic nucleus reuniens (NR)\, which is bidirectionally connected to both structures\, is therefore a strong candidate for mediating this dialogue. Using simultaneous silicon-probes recordings from the HPC\, NR\, and PFC in freely sleeping rats\, we identified a previously undescribed infra-slow rhythm (ISR) in NR neuronal activity predominantly during non-rapid eye movement (NREM) sleep.\nHPC and PFC neurons were differentially entrained to distinct phases of this rhythm. Consistently\, hippocampal sharp-wave ripples (SWRs) and prefrontal spindles occurred also preferentially during slightly different ISR phases. Coupled SWR–spindle events peaked at the onset of the ON phase.\nFurthermore\, this coupling was stronger during NREM epochs dominated by ISR compared to those without ISR\, and\, most importantly\, was significantly enhanced during ISR-dominated NREM sleep following spatial learning.\nTogether\, these findings reveal a novel infra-slow population dynamic in the NR that may temporally coordinate hippocampo–prefrontal interactions during sleep\, positioning this nucleus as a key hub in this network supporting memory consolidation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-pascale-quilichini/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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