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DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T200619
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:96559-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T200619
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:96561-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T200619
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:69646-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191129T100000
DTEND;TZID=Europe/Madrid:20191129T120000
DTSTAMP:20260403T200619
CREATED:20191125T105531Z
LAST-MODIFIED:20191125T105531Z
UID:96558-1575021600-1575028800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Ferran Velasco and Fabio Riefolo
DESCRIPTION:Cellulose-based cryogels for long-term culture of pancreatic islets and skeletal muscle tissue\nFerran Velasco\, Biosensors for Bioengineering\nIslet encapsulation inside traditional hydrogels is one of the most common techniques to study insulin secretion for Diabetes Mellitus studies. However\, it’s proved that cells encapsulated in a depth of more than 100 microns die due the lack of nutrient diffusion. As pancreatic islets are spherical aggregations of around 100 microns in diameter\, this problem increases exponentially. To solve this problem\, in this project we propose the use of new Carboxymethyl cellulose – gelatin biocomposite in combination with cryogelation technique to engineer a new in vitro model to mimic the insulin-mediated skeletal muscle glucose metabolism.\nCarboxymethyl cellulose (CMC) is biocompatible\, but not mammalian cell-degradable and shows extraordinary elasticity features. Gelatin is able to provide the 3D microenvironment for the proliferation of different cell types and cell-interactive biological activity\, very desirable properties for muscle and pancreas tissue scaffold. Cryogelation technique consists in freezing a prepolymer solution at sub-zero temperatures\, so water-ice crystals are formed while the material crosslinks. When it’s defrosted\, these water-ice crystals lead to “empty” cavities that forms a macroporous and very interconnected scaffold that fits with our needs of morphology and nutrient diffusion. \nWe first optimize the protocol to achieve the desired morphology; for the pancreatic tissue we achieved a random porosity with high interconnected pores and for the skeletal muscle we fabricate it with an anisotropic structure. We characterize it by stiffness\, pore distribution\, SEM images and swelling to know its mechanical properties. Then we seed cells in the specific cryogel to characterize its biological behavior depending the cryogel approach used. \nOur results are promising for seeding both cell types\, as the morphology and pore distributions fits with our needs. These scaffolds show higher nutrient diffusion\, good material properties and a better manipulation compared to traditional hydrogels for these tissues. \nPhotocontrol of Muscarinic Receptors and Applications In Vivo\nFabio Riefolo\, Nanoprobes and Nanoswitches\nRemote control of physiological functions with light offers the promise of unveiling their complex spatiotemporal dynamics in vivo\, and enabling highly focalized therapeutic interventions with reduced systemic toxicity. Optogenetic methods have been implemented in the heart\, but the need of genetic manipulation jeopardizes clinical applicability. We present a method to modulate cardiac function with light through a photoswitchable compound and without genetic manipulation. A new light-regulated drug\, named PAI\, was designed and synthesized to be active on M2 muscarinic acetylcholine receptor (mAChR). PAI can be reversibly photoisomerized between cis and trans conformations under UV and visible light and is able to photocontrol the activation M2 mAChRs in vitro. \nWe show that PAI has different light-dependent cardiac effects in a mammalian animal model. Finally\, we demonstrate the reversible\, real-time photocontrol of cardiac function in translucent wildtype tadpoles: PAI induced bradycardia and this effect could be reversibly switched using UV and visible illumination. PAI can also effectively activate M2 receptors using two-photon excitation with near-infrared light\, which overcomes the scattering and low penetration of short-wavelength illumination. Such a new approach may enable enhanced spatial and temporal selectivity for cardiovascular drugs.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-ferran-velasco-and-fabio-riefolo-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T200619
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96554-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T200619
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96557-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T200619
CREATED:20191118T093609Z
LAST-MODIFIED:20191119T141506Z
UID:69274-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260403T200619
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96552-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T200619
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96547-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T200619
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96550-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T200619
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96551-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260403T200619
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T094956Z
UID:69228-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T200619
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T154047Z
UID:69125-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T200619
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96539-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:IBEC Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquium\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T200619
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96541-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260403T200619
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96538-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191114T183000
DTEND;TZID=Europe/Madrid:20191114T193000
DTSTAMP:20260403T200619
CREATED:20191107T155232Z
LAST-MODIFIED:20191107T155232Z
UID:96533-1573756200-1573759800@ibecbarcelona.eu
SUMMARY:Què són els òrgans en un xip?  I la Bioenginyeria?
DESCRIPTION:Per al desenvolupament de nous fàrmacs\, la indústria depèn en gran manera de l’estudi amb models animals i amb cultius cel·lulars en 2D. Descobreix com la recerca innovadora en el desenvolupament d’òrgans en un xip pot contribuir a disminuir l’ús d’animals de laboratori i a millorar els estudis desenvolupant models en 3D. \nAmb la campanya de captació de fons del projecte Faster Future de l’IBEC\, i gràcies a persones com tu\, hem fet possible un dispositiu de múscul en un xip que permetrà provar fàrmacs al laboratori de forma fiable i econòmica. \nVine i descobreix en quina fase es troba el projecte i\, com gràcies a les aportacions econòmiques d’empreses i particulars\, hem pogut avançar una mica més cap a la medicina del futur. \nT’esperem a l’IBEC on podràs veure de primera mà aquest dispositiu i visitaràs el laboratori on s’ha desenvolupat la major part d’aquest projecte. \nApunta’t aquí
URL:https://ibecbarcelona.eu/event/que-son-els-organs-en-un-xip-i-la-bioenginyeria-2/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191114T183000
DTEND;TZID=Europe/Madrid:20191114T193000
DTSTAMP:20260403T200619
CREATED:20191107T155216Z
LAST-MODIFIED:20191107T155401Z
UID:69094-1573756200-1573759800@ibecbarcelona.eu
SUMMARY:Què són els òrgans en un xip?  I la Bioenginyeria?
DESCRIPTION:Per al desenvolupament de nous fàrmacs\, la indústria depèn en gran manera de l’estudi amb models animals i amb cultius cel·lulars en 2D. Descobreix com la recerca innovadora en el desenvolupament d’òrgans en un xip pot contribuir a disminuir l’ús d’animals de laboratori i a millorar els estudis desenvolupant models en 3D. \nAmb la campanya de captació de fons del projecte Faster Future de l’IBEC\, i gràcies a persones com tu\, hem fet possible un dispositiu de múscul en un xip que permetrà provar fàrmacs al laboratori de forma fiable i econòmica. \nVine i descobreix en quina fase es troba el projecte i\, com gràcies a les aportacions econòmiques d’empreses i particulars\, hem pogut avançar una mica més cap a la medicina del futur. \nT’esperem a l’IBEC on podràs veure de primera mà aquest dispositiu i visitaràs el laboratori on s’ha desenvolupat la major part d’aquest projecte. \nApunta’t aquí
URL:https://ibecbarcelona.eu/event/que-son-els-organs-en-un-xip-i-la-bioenginyeria/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191114T183000
DTEND;TZID=Europe/Madrid:20191114T193000
DTSTAMP:20260403T200619
CREATED:20191107T155216Z
LAST-MODIFIED:20191107T155216Z
UID:96535-1573756200-1573759800@ibecbarcelona.eu
SUMMARY:Què són els òrgans en un xip?  I la Bioenginyeria?
DESCRIPTION:Per al desenvolupament de nous fàrmacs\, la indústria depèn en gran manera de l’estudi amb models animals i amb cultius cel·lulars en 2D. Descobreix com la recerca innovadora en el desenvolupament d’òrgans en un xip pot contribuir a disminuir l’ús d’animals de laboratori i a millorar els estudis desenvolupant models en 3D. \nAmb la campanya de captació de fons del projecte Faster Future de l’IBEC\, i gràcies a persones com tu\, hem fet possible un dispositiu de múscul en un xip que permetrà provar fàrmacs al laboratori de forma fiable i econòmica. \nVine i descobreix en quina fase es troba el projecte i\, com gràcies a les aportacions econòmiques d’empreses i particulars\, hem pogut avançar una mica més cap a la medicina del futur. \nT’esperem a l’IBEC on podràs veure de primera mà aquest dispositiu i visitaràs el laboratori on s’ha desenvolupat la major part d’aquest projecte. \nApunta’t aquí
URL:https://ibecbarcelona.eu/event/que-son-els-organs-en-un-xip-i-la-bioenginyeria-3/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191114T183000
DTEND;TZID=Europe/Madrid:20191114T193000
DTSTAMP:20260403T200619
CREATED:20191107T155216Z
LAST-MODIFIED:20191107T155216Z
UID:96536-1573756200-1573759800@ibecbarcelona.eu
SUMMARY:Què són els òrgans en un xip?  I la Bioenginyeria?
DESCRIPTION:Per al desenvolupament de nous fàrmacs\, la indústria depèn en gran manera de l’estudi amb models animals i amb cultius cel·lulars en 2D. Descobreix com la recerca innovadora en el desenvolupament d’òrgans en un xip pot contribuir a disminuir l’ús d’animals de laboratori i a millorar els estudis desenvolupant models en 3D. \nAmb la campanya de captació de fons del projecte Faster Future de l’IBEC\, i gràcies a persones com tu\, hem fet possible un dispositiu de múscul en un xip que permetrà provar fàrmacs al laboratori de forma fiable i econòmica. \nVine i descobreix en quina fase es troba el projecte i\, com gràcies a les aportacions econòmiques d’empreses i particulars\, hem pogut avançar una mica més cap a la medicina del futur. \nT’esperem a l’IBEC on podràs veure de primera mà aquest dispositiu i visitaràs el laboratori on s’ha desenvolupat la major part d’aquest projecte. \nApunta’t aquí
URL:https://ibecbarcelona.eu/event/que-son-els-organs-en-un-xip-i-la-bioenginyeria-4/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191109T090000
DTEND;TZID=Europe/Madrid:20191109T183000
DTSTAMP:20260403T200619
CREATED:20191112T162733Z
LAST-MODIFIED:20191112T162733Z
UID:96543-1573290000-1573324200@ibecbarcelona.eu
SUMMARY:2nd EIT Health Innovation Day
DESCRIPTION:EIT Health Innovation Day\nInnovation Days promote health innovation among university students through one-to-two-day programmes held at academic institutions around Europe. Students receive an introduction to practical health innovation tools and work in multidisciplinary teams to tackle real life health challenges posed by EIT Health projects\, local organisations and private corporations. Successful teams will receive resources to develop their ideas\, and students from the regions EIT Health serves will be encouraged to get involved with our network. \nAbout this activity \nInnovation Days are accessible to all undergraduate and postgraduate students with an interest in healthcare innovation. Between 28 October-10 November 2019\, partners from six EIT Health Co-Location Centres and 13 RIS Hubs will host their own i-Days at 32 locations around Europe. \nThese events include inspirational speakers and coaches who will introduce students to practical tools in innovation\, design thinking and pitching ideas. Challenges sourced from EIT Health projects\, local CLCs\, and other relevant organisations\, will be presented to students along with some introductory information. Students form multidisciplinary teams and spend the day guided by facilitators and expert citizens in striving to create solutions to these real life healthcare challenges. Teams pitch their ideas and are judged by a panel of experts\, who use standardised scoring criteria to award prizes to the best teams. Winning i-Day teams will then be invited to a Winners Event\, where they meet peers from all participating i-Day universities. At this event\, students will be given support and resources to further develop their ideas\, and they will also receive more training in innovation methodology. The i-Days are conceived as a first step for students on the health innovation pathway. They encourage hundreds of students across European CLCs to join the EIT Health network. \nRegistration can be made individually or in teams. Teams should be built of multidisciplinary members\, that is to say of members from different faculties and academic programs or areas of research. \nRegistrations will be open until November 1th. \nFor any doubts or further info\, please contact: idaybarcelona@ub.edu
URL:https://ibecbarcelona.eu/event/2nd-eit-health-innovation-day-2/
LOCATION:Start UB
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191109T090000
DTEND;TZID=Europe/Madrid:20191109T183000
DTSTAMP:20260403T200619
CREATED:20191112T162733Z
LAST-MODIFIED:20191112T162733Z
UID:96544-1573290000-1573324200@ibecbarcelona.eu
SUMMARY:2nd EIT Health Innovation Day
DESCRIPTION:EIT Health Innovation Day\nInnovation Days promote health innovation among university students through one-to-two-day programmes held at academic institutions around Europe. Students receive an introduction to practical health innovation tools and work in multidisciplinary teams to tackle real life health challenges posed by EIT Health projects\, local organisations and private corporations. Successful teams will receive resources to develop their ideas\, and students from the regions EIT Health serves will be encouraged to get involved with our network. \nAbout this activity \nInnovation Days are accessible to all undergraduate and postgraduate students with an interest in healthcare innovation. Between 28 October-10 November 2019\, partners from six EIT Health Co-Location Centres and 13 RIS Hubs will host their own i-Days at 32 locations around Europe. \nThese events include inspirational speakers and coaches who will introduce students to practical tools in innovation\, design thinking and pitching ideas. Challenges sourced from EIT Health projects\, local CLCs\, and other relevant organisations\, will be presented to students along with some introductory information. Students form multidisciplinary teams and spend the day guided by facilitators and expert citizens in striving to create solutions to these real life healthcare challenges. Teams pitch their ideas and are judged by a panel of experts\, who use standardised scoring criteria to award prizes to the best teams. Winning i-Day teams will then be invited to a Winners Event\, where they meet peers from all participating i-Day universities. At this event\, students will be given support and resources to further develop their ideas\, and they will also receive more training in innovation methodology. The i-Days are conceived as a first step for students on the health innovation pathway. They encourage hundreds of students across European CLCs to join the EIT Health network. \nRegistration can be made individually or in teams. Teams should be built of multidisciplinary members\, that is to say of members from different faculties and academic programs or areas of research. \nRegistrations will be open until November 1th. \nFor any doubts or further info\, please contact: idaybarcelona@ub.edu
URL:https://ibecbarcelona.eu/event/2nd-eit-health-innovation-day-3/
LOCATION:Start UB
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191109T090000
DTEND;TZID=Europe/Madrid:20191109T183000
DTSTAMP:20260403T200619
CREATED:20191112T162733Z
LAST-MODIFIED:20191112T162733Z
UID:96546-1573290000-1573324200@ibecbarcelona.eu
SUMMARY:2nd EIT Health Innovation Day
DESCRIPTION:EIT Health Innovation Day\nInnovation Days promote health innovation among university students through one-to-two-day programmes held at academic institutions around Europe. Students receive an introduction to practical health innovation tools and work in multidisciplinary teams to tackle real life health challenges posed by EIT Health projects\, local organisations and private corporations. Successful teams will receive resources to develop their ideas\, and students from the regions EIT Health serves will be encouraged to get involved with our network. \nAbout this activity \nInnovation Days are accessible to all undergraduate and postgraduate students with an interest in healthcare innovation. Between 28 October-10 November 2019\, partners from six EIT Health Co-Location Centres and 13 RIS Hubs will host their own i-Days at 32 locations around Europe. \nThese events include inspirational speakers and coaches who will introduce students to practical tools in innovation\, design thinking and pitching ideas. Challenges sourced from EIT Health projects\, local CLCs\, and other relevant organisations\, will be presented to students along with some introductory information. Students form multidisciplinary teams and spend the day guided by facilitators and expert citizens in striving to create solutions to these real life healthcare challenges. Teams pitch their ideas and are judged by a panel of experts\, who use standardised scoring criteria to award prizes to the best teams. Winning i-Day teams will then be invited to a Winners Event\, where they meet peers from all participating i-Day universities. At this event\, students will be given support and resources to further develop their ideas\, and they will also receive more training in innovation methodology. The i-Days are conceived as a first step for students on the health innovation pathway. They encourage hundreds of students across European CLCs to join the EIT Health network. \nRegistration can be made individually or in teams. Teams should be built of multidisciplinary members\, that is to say of members from different faculties and academic programs or areas of research. \nRegistrations will be open until November 1th. \nFor any doubts or further info\, please contact: idaybarcelona@ub.edu
URL:https://ibecbarcelona.eu/event/2nd-eit-health-innovation-day-4/
LOCATION:Start UB
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191109T090000
DTEND;TZID=Europe/Madrid:20191109T183000
DTSTAMP:20260403T200619
CREATED:20191112T162733Z
LAST-MODIFIED:20191112T162742Z
UID:69141-1573290000-1573324200@ibecbarcelona.eu
SUMMARY:2nd EIT Health Innovation Day
DESCRIPTION:EIT Health Innovation Day\nInnovation Days promote health innovation among university students through one-to-two-day programmes held at academic institutions around Europe. Students receive an introduction to practical health innovation tools and work in multidisciplinary teams to tackle real life health challenges posed by EIT Health projects\, local organisations and private corporations. Successful teams will receive resources to develop their ideas\, and students from the regions EIT Health serves will be encouraged to get involved with our network. \nAbout this activity \nInnovation Days are accessible to all undergraduate and postgraduate students with an interest in healthcare innovation. Between 28 October-10 November 2019\, partners from six EIT Health Co-Location Centres and 13 RIS Hubs will host their own i-Days at 32 locations around Europe. \nThese events include inspirational speakers and coaches who will introduce students to practical tools in innovation\, design thinking and pitching ideas. Challenges sourced from EIT Health projects\, local CLCs\, and other relevant organisations\, will be presented to students along with some introductory information. Students form multidisciplinary teams and spend the day guided by facilitators and expert citizens in striving to create solutions to these real life healthcare challenges. Teams pitch their ideas and are judged by a panel of experts\, who use standardised scoring criteria to award prizes to the best teams. Winning i-Day teams will then be invited to a Winners Event\, where they meet peers from all participating i-Day universities. At this event\, students will be given support and resources to further develop their ideas\, and they will also receive more training in innovation methodology. The i-Days are conceived as a first step for students on the health innovation pathway. They encourage hundreds of students across European CLCs to join the EIT Health network. \nRegistration can be made individually or in teams. Teams should be built of multidisciplinary members\, that is to say of members from different faculties and academic programs or areas of research. \nRegistrations will be open until November 1th. \nFor any doubts or further info\, please contact: idaybarcelona@ub.edu
URL:https://ibecbarcelona.eu/event/2nd-eit-health-innovation-day/
LOCATION:Start UB
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191108T173000
DTEND;TZID=Europe/Madrid:20191108T193000
DTSTAMP:20260403T200619
CREATED:20191107T154535Z
LAST-MODIFIED:20191107T154535Z
UID:96530-1573234200-1573241400@ibecbarcelona.eu
SUMMARY:Bojos i boges per la Bioenginyeria: Els joves presenten les seves idees
DESCRIPTION:Vine i descobreix amb els ulls d’un estudiant de batxillerat la recerca en bioenginyeria! \nEn l’últim any\, 24 joves han participat en un programa d’immersió científica molt especial: Bojos i Boges per la Bioenginyeria. En aquesta sessió de cloenda\, els estudiants presentaran les seves pròpies idees sobre com resoldre problemes reals de salut. \nEts professor i vols saber com és un programa de formació en recerca per a estudiants de secundària? Ets un estudiant de secundària i estàs pensant a participar en una de les pròximes edicions? Tens curiositat per saber com afrontaran la recerca les noves generacions i com la bioenginyeria hi jugarà un paper fonamental? Si la resposta a alguna d’aquestes preguntes és sí\, no t’ho pots perdre! \nInscriu-te aquí
URL:https://ibecbarcelona.eu/event/bojos-i-boges-per-la-bioenginyeria-els-joves-presenten-les-seves-idees-3/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191108T173000
DTEND;TZID=Europe/Madrid:20191108T193000
DTSTAMP:20260403T200619
CREATED:20191107T154535Z
LAST-MODIFIED:20191107T154535Z
UID:96532-1573234200-1573241400@ibecbarcelona.eu
SUMMARY:Bojos i boges per la Bioenginyeria: Els joves presenten les seves idees
DESCRIPTION:Vine i descobreix amb els ulls d’un estudiant de batxillerat la recerca en bioenginyeria! \nEn l’últim any\, 24 joves han participat en un programa d’immersió científica molt especial: Bojos i Boges per la Bioenginyeria. En aquesta sessió de cloenda\, els estudiants presentaran les seves pròpies idees sobre com resoldre problemes reals de salut. \nEts professor i vols saber com és un programa de formació en recerca per a estudiants de secundària? Ets un estudiant de secundària i estàs pensant a participar en una de les pròximes edicions? Tens curiositat per saber com afrontaran la recerca les noves generacions i com la bioenginyeria hi jugarà un paper fonamental? Si la resposta a alguna d’aquestes preguntes és sí\, no t’ho pots perdre! \nInscriu-te aquí
URL:https://ibecbarcelona.eu/event/bojos-i-boges-per-la-bioenginyeria-els-joves-presenten-les-seves-idees-4/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191108T173000
DTEND;TZID=Europe/Madrid:20191108T193000
DTSTAMP:20260403T200620
CREATED:20191107T154535Z
LAST-MODIFIED:20191111T142140Z
UID:69088-1573234200-1573241400@ibecbarcelona.eu
SUMMARY:Bojos i boges per la Bioenginyeria: Els joves presenten les seves idees
DESCRIPTION:Vine i descobreix amb els ulls d’un estudiant de batxillerat la recerca en bioenginyeria! \nEn l’últim any\, 24 joves han participat en un programa d’immersió científica molt especial: Bojos i Boges per la Bioenginyeria. En aquesta sessió de cloenda\, els estudiants presentaran les seves pròpies idees sobre com resoldre problemes reals de salut. \nEts professor i vols saber com és un programa de formació en recerca per a estudiants de secundària? Ets un estudiant de secundària i estàs pensant a participar en una de les pròximes edicions? Tens curiositat per saber com afrontaran la recerca les noves generacions i com la bioenginyeria hi jugarà un paper fonamental? Si la resposta a alguna d’aquestes preguntes és sí\, no t’ho pots perdre! \nInscriu-te aquí
URL:https://ibecbarcelona.eu/event/bojos-i-boges-per-la-bioenginyeria-els-joves-presenten-les-seves-idees/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191108T173000
DTEND;TZID=Europe/Madrid:20191108T193000
DTSTAMP:20260403T200620
CREATED:20191107T154535Z
LAST-MODIFIED:20191107T154535Z
UID:96529-1573234200-1573241400@ibecbarcelona.eu
SUMMARY:Bojos i boges per la Bioenginyeria: Els joves presenten les seves idees
DESCRIPTION:Vine i descobreix amb els ulls d’un estudiant de batxillerat la recerca en bioenginyeria! \nEn l’últim any\, 24 joves han participat en un programa d’immersió científica molt especial: Bojos i Boges per la Bioenginyeria. En aquesta sessió de cloenda\, els estudiants presentaran les seves pròpies idees sobre com resoldre problemes reals de salut. \nEts professor i vols saber com és un programa de formació en recerca per a estudiants de secundària? Ets un estudiant de secundària i estàs pensant a participar en una de les pròximes edicions? Tens curiositat per saber com afrontaran la recerca les noves generacions i com la bioenginyeria hi jugarà un paper fonamental? Si la resposta a alguna d’aquestes preguntes és sí\, no t’ho pots perdre! \nInscriu-te aquí
URL:https://ibecbarcelona.eu/event/bojos-i-boges-per-la-bioenginyeria-els-joves-presenten-les-seves-idees-2/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260403T200620
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084555Z
UID:96526-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260403T200620
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084555Z
UID:96528-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
END:VCALENDAR