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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260513T140000
DTEND;TZID=Europe/Madrid:20260513T150000
DTSTAMP:20260610T014717
CREATED:20260320T101141Z
LAST-MODIFIED:20260320T101141Z
UID:132912-1778680800-1778684400@ibecbarcelona.eu
SUMMARY:Ibec Seminar:  Dr Pascale Quilichini
DESCRIPTION:Neuronal infra-slow rhythm in the thalamic nucleus reuniens orchestrate hippocampo-prefrontal information flow during sleep\nDr Pascale Quilichini\, Institut de Neurosciences des Systèmes\, INSERM\, Aix-Marseille University \nThe consolidation of episodic memory during sleep relies on coordinated interactions between the hippocampus (HPC) and the prefrontal cortex (PFC)\, although these regions lack direct reciprocal connections. The thalamic nucleus reuniens (NR)\, which is bidirectionally connected to both structures\, is therefore a strong candidate for mediating this dialogue. Using simultaneous silicon-probes recordings from the HPC\, NR\, and PFC in freely sleeping rats\, we identified a previously undescribed infra-slow rhythm (ISR) in NR neuronal activity predominantly during non-rapid eye movement (NREM) sleep.\nHPC and PFC neurons were differentially entrained to distinct phases of this rhythm. Consistently\, hippocampal sharp-wave ripples (SWRs) and prefrontal spindles occurred also preferentially during slightly different ISR phases. Coupled SWR–spindle events peaked at the onset of the ON phase.\nFurthermore\, this coupling was stronger during NREM epochs dominated by ISR compared to those without ISR\, and\, most importantly\, was significantly enhanced during ISR-dominated NREM sleep following spatial learning.\nTogether\, these findings reveal a novel infra-slow population dynamic in the NR that may temporally coordinate hippocampo–prefrontal interactions during sleep\, positioning this nucleus as a key hub in this network supporting memory consolidation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-pascale-quilichini/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260513T153000
DTEND;TZID=Europe/Madrid:20260513T173000
DTSTAMP:20260610T014717
CREATED:20260507T094614Z
LAST-MODIFIED:20260507T094614Z
UID:133571-1778686200-1778693400@ibecbarcelona.eu
SUMMARY:Diàlegs Oberts. Un programa de co-creació entre artistes i personal investigador de l'IBEC
DESCRIPTION:El proper 13 de maig a les 15:30 h s’inaugurarà al PCB (C/ Baldiri Reixac\, 4-12 i 15 – 08028 Barcelona) l’exposició Diàlegs Oberts: Processos Compartits entre Art i Ciència. La mostra presenta les obres creades col·lectivament entre artistes i investigadorxs de l’IBEC\, mostrant el procés creatiu compartit i les preguntes i intuïcions que han sorgit al llarg de la seva col·laboració. L’exposició convida el públic a endinsar-se en aquest espai de trobada interdisciplinari\, on l’art i la ciència dialoguen per generar noves maneres de percebre\, interpretar i compartir coneixement. \nPrograma \n\n\n\nRegistre \n15:00 h – 15:30 h\n\n\nBenvinguda \n15:30 h\n\n\nShowcase Creatiu dels tàndems\n16:00 h\n\n\nVisita exposició\n15:00 h – 17:30 h\n\n\n\nPer registrar-se click aquí
URL:https://ibecbarcelona.eu/event/dialegs-oberts-un-programa-de-co-creacio-entre-artistes-i-personal-investigador-de-libec/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260515T100000
DTEND;TZID=Europe/Madrid:20260515T110000
DTSTAMP:20260610T014717
CREATED:20260512T075315Z
LAST-MODIFIED:20260512T075315Z
UID:133577-1778839200-1778842800@ibecbarcelona.eu
SUMMARY:PhD Discussion: Aina Albajar and Ainhoa Gonzalez
DESCRIPTION:Studying the mechanical regulation of nucleocytoplasmic transport using Single Molecule Tracking\n\nAina Albajar-Sigalé\, Cellular and Molecular Mechanobiology Group \nCellular function relies on the precise regulation of macromolecular transport between the cytoplasm and the nucleus\, a process governed by Nuclear Pore Complexes (NPCs). While traditional understanding held that transport through NPCs was mainly dictated by the physicochemical properties of the transported molecules\, recent research has revealed an additional layer of regulation driven by mechanical forces. Whether applied directly or transmitted through the cytoskeleton\, mechanical signals have the capacity to deform the nucleus and\, consequently\, alter the conformation of NPCs\, increasing their diameter. This changes nucleocytoplasmic transport rates and impacts the localisation of a variety of signalling molecules. However\, the cellular components responsible for force transmission to NPCs as well as the spatial distribution of this effect throughout the nuclear envelope\, remain poorly understood. Here\, we aim to answer these questions by investigating whether isolated nuclei\, a minimal system depleted of all the cell’s cytoplasmic machinery\, still exhibit mechanosensitive nucleocytoplasmic transport. To do so\, we apply mechanical force by confining isolated nuclei to a certain micrometre height and\, simultaneously\, measure nucleocytoplasmic transport rates by tracking individual dextran molecules translocating through NPCs. Our results show that molecules translocate faster in confined nuclei\, suggesting that unspecific force application to a passive nuclear envelope is enough to induce conformational changes in NPCs and alter transport dynamics. \n  \n\nLaser-Induced Vapor Nanobubbles Trigger Immunogenic Cell Death Prophylactic Immunity in Bladder Cancer Models\n\nAinhoa G. Caelles\, Smart Nano-Bio-Devices Group \nBladder cancer (BC) is the 10th most common malignancy worldwide\, and despite treatments such as intravesical chemotherapy and Bacille Calmette-Guérin (BCG) immunotherapy\, high relapse rates persist\, especially in non-muscular invasive BC (NMIBC). Photothermal therapy (PTT) emerges as a promising non-invasive approach inducing tumor ablation while promoting immunogenic cell death (ICD). This project studies iron oxide nanoparticles (IONPs) as photosensitizers for laser-induced vapor nanobubbles (VNBs) in MB49 cells and its potential to induce cell death and prevent tumor relapse in subcutaneous/orthotopic murine models.
URL:https://ibecbarcelona.eu/event/phd-discussion-aina-albajar-and-ainhoa-gonzalez/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260529T100000
DTEND;TZID=Europe/Madrid:20260529T110000
DTSTAMP:20260610T014717
CREATED:20260507T093943Z
LAST-MODIFIED:20260527T134235Z
UID:133565-1780048800-1780052400@ibecbarcelona.eu
SUMMARY:Ibec Seminar: Giorgio Volpe
DESCRIPTION:Steering Self-organization in Active Colloids and Droplets through Confinement\nConfinement\, whether externally imposed or generated by the system itself\, plays a central role in shaping the dynamics and self-organization of active matter. In natural systems\, such as microbial communities and social insects\, self-reinforced confinement is exploited to create functional structures and accomplish complex collective tasks. In contrast\, the potential of such mechanisms in synthetic active systems remains largely unexplored. In this talk\, I will present our recent work demonstrating how confinement can be harnessed as a generic design principle to program collective behaviour in active matter and non-equilibrium systems with applications in micro-robotics\, 4D printing\, and organic electronics.\n\nGiorgio Volpe is Professor of Soft Matter and group leader of the Soft Active Matter laboratory in the Department of Chemistry\, University College London. He obtained his PhD in Photonics at ICFO – The Institute of Photonic Sciences in Barcelona (Spain) in 2012. His current research focuses on studying the emergence of non-equilibrium phenomena in both biological and synthetic soft matter for applications in materials science and healthcare. To date\, he has published more than 50 peer-reviewed research articles and reviews in high-impact journals for the fields of active matter\, soft matter and photonics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-giorgio-volpe/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260605T100000
DTEND;TZID=Europe/Madrid:20260605T110000
DTSTAMP:20260610T014717
CREATED:20260529T062937Z
LAST-MODIFIED:20260602T100143Z
UID:133839-1780653600-1780657200@ibecbarcelona.eu
SUMMARY:PhD Discussion. Margherita Gallano and Carles Prado Morales
DESCRIPTION:Nuclear Envelope Remodelling under Mechanical Perturbation\nMargherita Gallano\, predoctoral researcher in the Cellular and Molecular Mechanobiology Group \nCells experience mechanical loads during many fundamental processes\, including growth\, differentiation\, and migration. These forces are transmitted to the nucleus and can influence gene expression\, ultimately modulating cell behaviour and determining cell fate. The Nuclear Envelope (NE) plays a critical role in this process\, as it has been shown to sense cell size variations and activate mechanosensitive signalling pathways. Yet\, the phenomenology of NE responses to mechanical stimuli remains largely unexplored. In this project\, we aim to characterize the dynamic response of the NE under both stretch and compression\, and to unravel the associated mechanosensing mechanisms. To do so\, we employ a custom-made microfluidic device to apply controlled stretch to HeLa cells nuclei and a nanoindenter to subject cells to compressive loads. Using single cells and isolated nuclei as model systems\, we aim to distinguish active from passive processes of NE remodelling. Our results demonstrate that isolated nuclei undergo NE remodelling upon strain application\, characterised by flattening of nuclear envelope wrinkles and increase in nuclear volume. In indentation experiments on intact HeLa cells\, we observe rapid NE wrinkling upon release of the compressive load\, followed by a gradual restoration of the original nuclear morphology. \n  \nTopical enzyme-powered nano-mRNA vaccines\nCarles Prado\, Smart Nano-Bio-Devices group \nThe skin constitutes the body’s primary defensive barrier\, a function attributed to its complex and highly dense architecture. Beyond its protective role\, the skin also represents a promising route for drug delivery and vaccination. Current vaccination strategies primarily rely on injectable administration\, which targets tissues with relatively low densities of antigen-presenting cells (APCs). This approach can result in limited efficiency\, reduced patient compliance\, increased infection risk\, and higher healthcare costs. In contrast\, skin contains a dense network of resident APCs\, making it an attractive target for immunization. However\, most topical delivery approaches require physical disruption of the stratum corneum (SC) to overcome the barrier\, causing adverse effects and local tissue damage. To address these limitations\, we have developed a novel needle-free delivery platform based on enzymatically powered nanomotors capable of actively and non-disruptively penetrating the skin barrier. Through self-propulsion and local modulation of the lipid organization of the SC\, these nanomotors enhance transport into the viable epidermis and dermis. Our goal is to employ this technology to topically deliver mRNA to epidermal Langerhans cells and dermal dendritic cells and to evaluate its performance in a human relevant model.
URL:https://ibecbarcelona.eu/event/phd-discussion-margherita-gallano-and-carles-prado-morales/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260612T100000
DTEND;TZID=Europe/Madrid:20260612T110000
DTSTAMP:20260610T014717
CREATED:20260529T063846Z
LAST-MODIFIED:20260529T063846Z
UID:133843-1781258400-1781262000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Santiago A. Rodríguez-Seguí
DESCRIPTION:Epigenomic Control of Pancreatic β-Cell Development and Fate: Toward Engineering a Vascularized Organoid-on-Chip Platform\nSantiago A. Rodríguez-Seguí1\,2 \n1 Instituto de Fisiología\, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET)\, Universidad de Buenos Aires\, Facultad de Ciencias Exactas y Naturales\, Buenos Aires\, Argentina. \n2 Departamento de Fisiología\, Biología Molecular y Celular\, Universidad de Buenos Aires\, Facultad de Ciencias Exactas y Naturales\, Ciudad Universitaria\, Buenos Aires\, Argentina. \nThe human genome encodes the instructions for the vast cellular differentiation required for embryonic development and adult homeostasis. Some developmental programs are reactivated during regeneration upon tissue damage. Decoding this regulatory logic demands integrated approaches: the development of suitable human tissue models\, genomic characterization of transcriptional and epigenetic programs\, and experimental validation. State-of-the-art bioengineering technologies — including microfluidic and biomaterial platforms that recapitulate tissue microenvironments — are enabling insights into human biology that would otherwise be difficult to achieve. \nDiabetes is associated with malfunction of pancreatic β-cells. Our work\, based on pioneering ChIP-seq and scRNA-seq studies in human and mouse pancreatic samples — adult islets\, embryonic pancreas\, and iPSC-derived progenitors — has identified regulatory mechanisms controlling β-cell development and fate. We mapped the enhancer landscape of human islets\, uncovered enhancer mutations causing pancreatic agenesis\, and demonstrated that TEAD and YAP regulate key enhancers during pancreatic development. More recently\, we showed that glucocorticoid receptor activation modulates early differentiation in pancreatic progenitors\, and that HNF1B mutations disrupt this process in iPSC-derived models. From the regenerative angle\, we reported that the peptide INGAP-PP signals to multiple islet cell types\, including β-cells and endothelial cells\, suggesting that its effects depend on multicellular crosstalk poorly captured by conventional culture. \nBuilding on this foundation\, we are now developing a vascularized pancreatic endocrine organoid-on-chip platform that recapitulates the β-cell vascular niche. This platform\, developed in collaboration with the University of Barcelona and IBEC\, integrates human β-cells\, endothelial cells\, and stromal cells in a perfusable microfluidic device. It will enable epigenomic dissection of how vascular niche signals modulate the enhancer landscape underlying β-cell fate in a controlled human microenvironment. Our long-term vision is to translate this mechanistic understanding into precision medicine approaches for diabetes. \nSantiago Rodríguez Seguí is a Principal Investigator at the Institute for Physiology\, Molecular Biology\, and Neurosciences (IFIBYNE)\, affiliated with the National Scientific and Technical Research Council of Argentina (CONICET) and the University of Buenos Aires. He holds a degree in Bioengineering from the University of Entre Ríos\, Argentina\, and a PhD in Biomedicine from the University of Barcelona\, Spain. \nHis research focuses on pancreatic beta cell development and regeneration. He has authored more than 20 publications\, with significant contributions to the field published in high-impact journals such as Nature Genetics\, Nature Cell Biology\, and Development. His work has been recognized with awards from the National Academy of Medicine of Argentina and the Honorable Senate of the Argentine Nation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-santiago-a-rodriguez-segui/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260612T111500
DTEND;TZID=Europe/Madrid:20260612T121500
DTSTAMP:20260610T014717
CREATED:20260609T065838Z
LAST-MODIFIED:20260609T065838Z
UID:134002-1781262900-1781266500@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Dr. Le Cam
DESCRIPTION:The p53 pathway and metabolism: implications in normal tissue homeostasis\, aging and cancer progression\nDr. Le Cam \, Montpellier Cancer Research Institute (IRCM) \nMutation of the TP53 gene is the most frequent genetic alteration in human cancers. Tumor suppressive functions of p53 have been linked to its ability to control cell division\, cell death and cellular senescence. However growing evidence indicates that the metabolic functions of p53 play important roles in cancer progression. Our team has been studying the metabolic functions of the p53 pathway for many years and highlighted previously unknown functions of several key components of this molecular cascade in pyruvate\, amino-acid\, and nucleotide metabolism. Beyond cancer development\, I will illustrate how deregulation of these metabolic networks impacts on normal physiological responses in the liver\, contributes to cancer development and leads to inborn metabolic disorders. \nRelevant publications: \n1- Riscal R. et al (2016) Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53. Mol. Cell. Jun 16;62(6):890-902. \n2- Arena et al. Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 2018 \n3- Cissé et al. Targeting MDM2-dependent serine metabolism as a new therapeutic strategy for liposarcoma. Sci Trans Med 2020 \n4- Lacroix et al. The multifunctional protein E4F1 links p53 to lipid metabolism in adipocytes. Nat Comms 2021 \n5- Di Michele et al. E4F1 coordinates pyruvate metabolism and the activity of the Elongator Complex to ensure protein translation fidelity. Nat Comms 2025 \n  \nDr. Le Cam earned his Pharmacy thesis and his PhD in Science from Montpellier University (France) in 1999. From 1999 to 2004\, he spent four years as a postdoctoral fellow in Professor Sicinski’s laboratory at the Dana-Farber Cancer Institute in Boston (USA)\, where he studied cell cycle and mouse genetics. He then joined the French National Institute of Health and Medical Research (INSERM) as a researcher at the Institute of Molecular Genetics of Montpellier in Dr. Claude Sardet’s laboratory. In 2008\, he became a group leader at the Montpellier Cancer Research Institute (IRCM)\, where he was appointed deputy director in 2022. His team investigates the metabolic functions of p53\, the most frequently mutated tumor suppressor across many cancer types\, and how their deregulation impinges on metabolic disorders\, aging and cancer progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-le-cam/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260618T090000
DTEND;TZID=Europe/Madrid:20260618T150000
DTSTAMP:20260610T014717
CREATED:20260529T061827Z
LAST-MODIFIED:20260529T061827Z
UID:133833-1781773200-1781794800@ibecbarcelona.eu
SUMMARY:IBEC Day
DESCRIPTION:IBEC Day brings together the entire IBEC community for a day of exchange and connection\, designed to share\, connect and celebrate together. \nThis year’s edition is particularly meaningful\, as it forms part of the celebration of IBEC’s 20th anniversary\, marking an important milestone for the institute and offering an opportunity to look back\, recognise the journey so far\, and continue building the future in a shared way. \nThroughout the day\, we will present relevant updates and developments across the institution\, learn about ongoing initiatives\, and create spaces for conversation in an informal setting. \nIBEC Day aims to strengthen our sense of belonging\, foster dialogue\, and offer an opportunity to experience a day that helps us feel more connected as an institution.
URL:https://ibecbarcelona.eu/event/ibec-day/
LOCATION:Auditori Vèrtex – UPC
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260618T173000
DTEND;TZID=Europe/Madrid:20260618T210000
DTSTAMP:20260610T014717
CREATED:20260515T062616Z
LAST-MODIFIED:20260515T062730Z
UID:133600-1781803800-1781816400@ibecbarcelona.eu
SUMMARY:Alumni IBEC - 20 Years of Community
DESCRIPTION:On the occasion of the 20th anniversary of IBEC\, we are pleased to invite the entire Alumni community to a special event taking place on June 18th at 5:30 pm at the Auditori Antoni Caparrós (PCB).  \nThis gathering aims to reconnect all those who have been part of IBEC over the past 20 years\, share professional journeys\, exchange experiences and strengthen a diverse and active Alumni network with impact across many fields.  \nIt will be an afternoon to meet again\, enjoy meaningful networking\, discover new professional stories shaped by IBEC\, and collectively celebrate the path travelled and the talent that has grown within the institute.  \nThe event will conclude with a cocktail reception from 7:00 pm\, offering a relaxed environment to continue conversations and build connections. 
URL:https://ibecbarcelona.eu/event/alumni-ibec-20-years-of-community/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
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