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DTSTART;TZID=Europe/Madrid:20220225T100000
DTEND;TZID=Europe/Madrid:20220225T170000
DTSTAMP:20220427T110714Z
CREATED:20220427T110714Z
LAST-MODIFIED:20220427T110714Z
UID:93905-1645783200-1645808400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Giulia Fornabaio and Shubham Tanwar
DESCRIPTION:Biomechanics of the progression of colorectal carcinomas\n\n\n\nGiulia Fornabaio\, Synthetic morphogenesis group \n\n\n\nAccording to the World Health Organization\, cancer is one of the main causes of death worldwide\, with colorectal carcinoma (CRC) being the second-leading cause of tumour related-death. The high rate of mortality of CRCs is principally attributed to the metastasis of neoplastic cells from the primary tumour to secondary organs such as the liver\, the lung and the peritoneum. These cells can disseminate either as single isolated cells or as collective clusters\, undergoing a series of molecular and cellular changes commonly known as Epithelial to Mesenchymal Transition (EMT). However\, in 2018\, Jaulin and her team described a novel modality of peritoneal metastatic spread characterized by the presence of large clusters of cancer cells\, which maintain their epithelial properties and display an outward apical polarity. These clusters of cells\, termed tumour spheres with inverted polarity (TSIPs)\, were found in peritoneal effusions of CRCs patients showing early KRAS mutation and hypermethylation of CpG Islands. \n\n\n\nTSIPs originate through a series of morphological changes: the first event is the sprouting of hypermethylated epithelia\, followed by their apical budding\, leading to the formation of rounded spherical clusters of cells called buds\, and the subsequent cleavage of the newly formed spheres. How cell and tissue mechanics drive this process is still unclear. To provide novel insights into this metastatic cascade\, our project aims at deciphering the biomechanical and cellular events regulating the formation of buds in colorectal cancer cell lines. Employing a combination between cellular biology techniques with biophysical methods\, we showed that this process is characterized by over-proliferation and local changes in cell adhesion\, coupled with the formation of cellular vortexes surrounding the buds. Our study demonstrates that buds development in colorectal carcinomas epithelia is governed by morphological transitions occurring entirely at multicellular level\, rather than by single cells aggregation or cell extrusion. \n\n\n\nImaging Functional Organic Bioelectronic Platforms at the Nanoscale\n\n\n\nShubham Tanwar\, Nanoscale Bioelectrical Characterization group \n\n\n\nIn recent years\, many organic bioelectronic platforms have emerged to bridge the signaling gap between biology and technology. Organic bioelectronic platforms based on transistor architecture\, commonly known as Electrolyte-Gated Transistors (EGTs)\, are an excellent tool to selectively sense\, record\, and monitor biological signals and states\, and convert them into measurable electrical signals.1 Biological events happening at the nanoscale are now routinely studied and characterized by a millimeter-sized transistor. However\, it is not well understood how these nanoscale events interact with the transistor’s nanoscale properties leading to a change in their macroscale response. This gap in understanding is purely due to the lack of techniques to image the electrical properties in a liquid environment. Towards this goal\, our group has adapted in-Liquid Scanning Dielectric Microscopy to unravel the inner working of EGTs at the nanoscale.2 Besides apparent topographical changes\, electrical properties\, like conductivity and interfacial capacitance\, and mechanical properties are mapped at the nanoscale in a working transistor in liquid. The vast information extracted has made it possible to correlate the nanoscale processes with the macroscale response\, offering improved understanding and the potential for substantial optimization of bioelectronic devices. \n\n\n\nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/phd-discussions-giulia-fornabaio-and-shubham-tanwar/
LOCATION:IBEC\, floor 11\, Tower i
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220225T100000
DTEND;TZID=Europe/Madrid:20220225T170000
DTSTAMP:20220218T094610Z
CREATED:20220218T094610Z
LAST-MODIFIED:20220218T094610Z
UID:90539-1645783200-1645808400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Giulia Fornabaio and Shubham Tanwar
DESCRIPTION:Biomechanics of the progression of colorectal carcinomas\nGiulia Fornabaio\, Synthetic morphogenesis group \nAccording to the World Health Organization\, cancer is one of the main causes of death worldwide\, with colorectal carcinoma (CRC) being the second-leading cause of tumour related-death. The high rate of mortality of CRCs is principally attributed to the metastasis of neoplastic cells from the primary tumour to secondary organs such as the liver\, the lung and the peritoneum. These cells can disseminate either as single isolated cells or as collective clusters\, undergoing a series of molecular and cellular changes commonly known as Epithelial to Mesenchymal Transition (EMT). However\, in 2018\, Jaulin and her team described a novel modality of peritoneal metastatic spread characterized by the presence of large clusters of cancer cells\, which maintain their epithelial properties and display an outward apical polarity. These clusters of cells\, termed tumour spheres with inverted polarity (TSIPs)\, were found in peritoneal effusions of CRCs patients showing early KRAS mutation and hypermethylation of CpG Islands. \nTSIPs originate through a series of morphological changes: the first event is the sprouting of hypermethylated epithelia\, followed by their apical budding\, leading to the formation of rounded spherical clusters of cells called buds\, and the subsequent cleavage of the newly formed spheres. How cell and tissue mechanics drive this process is still unclear. To provide novel insights into this metastatic cascade\, our project aims at deciphering the biomechanical and cellular events regulating the formation of buds in colorectal cancer cell lines. Employing a combination between cellular biology techniques with biophysical methods\, we showed that this process is characterized by over-proliferation and local changes in cell adhesion\, coupled with the formation of cellular vortexes surrounding the buds. Our study demonstrates that buds development in colorectal carcinomas epithelia is governed by morphological transitions occurring entirely at multicellular level\, rather than by single cells aggregation or cell extrusion. \nImaging Functional Organic Bioelectronic Platforms at the Nanoscale\nShubham Tanwar\, Nanoscale Bioelectrical Characterization group \nIn recent years\, many organic bioelectronic platforms have emerged to bridge the signaling gap between biology and technology. Organic bioelectronic platforms based on transistor architecture\, commonly known as Electrolyte-Gated Transistors (EGTs)\, are an excellent tool to selectively sense\, record\, and monitor biological signals and states\, and convert them into measurable electrical signals.1 Biological events happening at the nanoscale are now routinely studied and characterized by a millimeter-sized transistor. However\, it is not well understood how these nanoscale events interact with the transistor’s nanoscale properties leading to a change in their macroscale response. This gap in understanding is purely due to the lack of techniques to image the electrical properties in a liquid environment. Towards this goal\, our group has adapted in-Liquid Scanning Dielectric Microscopy to unravel the inner working of EGTs at the nanoscale.2 Besides apparent topographical changes\, electrical properties\, like conductivity and interfacial capacitance\, and mechanical properties are mapped at the nanoscale in a working transistor in liquid. The vast information extracted has made it possible to correlate the nanoscale processes with the macroscale response\, offering improved understanding and the potential for substantial optimization of bioelectronic devices. \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/phd-discussions-giulia-fornabaio-and-shubham-tanwar-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220225T100000
DTEND;TZID=Europe/Madrid:20220225T170000
DTSTAMP:20220218T094610Z
CREATED:20220218T094610Z
LAST-MODIFIED:20220218T094610Z
UID:96527-1645783200-1645808400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Giulia Fornabaio and Shubham Tanwar
DESCRIPTION:Biomechanics of the progression of colorectal carcinomas\nGiulia Fornabaio\, Synthetic morphogenesis group \nAccording to the World Health Organization\, cancer is one of the main causes of death worldwide\, with colorectal carcinoma (CRC) being the second-leading cause of tumour related-death. The high rate of mortality of CRCs is principally attributed to the metastasis of neoplastic cells from the primary tumour to secondary organs such as the liver\, the lung and the peritoneum. These cells can disseminate either as single isolated cells or as collective clusters\, undergoing a series of molecular and cellular changes commonly known as Epithelial to Mesenchymal Transition (EMT). However\, in 2018\, Jaulin and her team described a novel modality of peritoneal metastatic spread characterized by the presence of large clusters of cancer cells\, which maintain their epithelial properties and display an outward apical polarity. These clusters of cells\, termed tumour spheres with inverted polarity (TSIPs)\, were found in peritoneal effusions of CRCs patients showing early KRAS mutation and hypermethylation of CpG Islands. \nTSIPs originate through a series of morphological changes: the first event is the sprouting of hypermethylated epithelia\, followed by their apical budding\, leading to the formation of rounded spherical clusters of cells called buds\, and the subsequent cleavage of the newly formed spheres. How cell and tissue mechanics drive this process is still unclear. To provide novel insights into this metastatic cascade\, our project aims at deciphering the biomechanical and cellular events regulating the formation of buds in colorectal cancer cell lines. Employing a combination between cellular biology techniques with biophysical methods\, we showed that this process is characterized by over-proliferation and local changes in cell adhesion\, coupled with the formation of cellular vortexes surrounding the buds. Our study demonstrates that buds development in colorectal carcinomas epithelia is governed by morphological transitions occurring entirely at multicellular level\, rather than by single cells aggregation or cell extrusion. \nImaging Functional Organic Bioelectronic Platforms at the Nanoscale\nShubham Tanwar\, Nanoscale Bioelectrical Characterization group \nIn recent years\, many organic bioelectronic platforms have emerged to bridge the signaling gap between biology and technology. Organic bioelectronic platforms based on transistor architecture\, commonly known as Electrolyte-Gated Transistors (EGTs)\, are an excellent tool to selectively sense\, record\, and monitor biological signals and states\, and convert them into measurable electrical signals.1 Biological events happening at the nanoscale are now routinely studied and characterized by a millimeter-sized transistor. However\, it is not well understood how these nanoscale events interact with the transistor’s nanoscale properties leading to a change in their macroscale response. This gap in understanding is purely due to the lack of techniques to image the electrical properties in a liquid environment. Towards this goal\, our group has adapted in-Liquid Scanning Dielectric Microscopy to unravel the inner working of EGTs at the nanoscale.2 Besides apparent topographical changes\, electrical properties\, like conductivity and interfacial capacitance\, and mechanical properties are mapped at the nanoscale in a working transistor in liquid. The vast information extracted has made it possible to correlate the nanoscale processes with the macroscale response\, offering improved understanding and the potential for substantial optimization of bioelectronic devices. \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/phd-discussions-giulia-fornabaio-and-shubham-tanwar-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220204T100000
DTEND;TZID=Europe/Madrid:20220204T130000
DTSTAMP:20220427T085707Z
CREATED:20220427T085707Z
LAST-MODIFIED:20220427T085707Z
UID:93900-1643968800-1643979600@ibecbarcelona.eu
SUMMARY:Nanodía mundial contra el cáncer – 2022
DESCRIPTION:El Nanodía Mundial Contra el Cáncer es un evento organizado en el marco del Día Mundial contra el Cáncer donde se darán a conocer las últimas innovaciones en materia de NANOMEDICINA contra el CÁNCER\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \n\n\n\nUn año más\, expertos en NANOMEDICINA de diferentes campos -investigadores\, empresarios\, médicos oncólogos\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la NANOMEDICINA significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer y como podemos contribuir en la misión Europea contra el cáncer. \n\n\n\nIniciado bajo el nombre de NANO WORLD CANCER DAY\, NANOMED Spain organiza la edición de este año de manera virtual con la colaboración del VHIR (Vall d’Hebron Instituto de Investigación) y el VHIO (Vall d’Hebron Instituto de Oncología).  \n\n\n\nMás información y registro aquí.
URL:https://ibecbarcelona.eu/event/nanodia-mundial-contra-el-cancer-2022/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220204T100000
DTEND;TZID=Europe/Madrid:20220204T130000
DTSTAMP:20220427T085707Z
CREATED:20220427T085707Z
LAST-MODIFIED:20220427T085707Z
UID:93901-1643968800-1643979600@ibecbarcelona.eu
SUMMARY:Nanodía mundial contra el cáncer – 2022
DESCRIPTION:El Nanodía Mundial Contra el Cáncer es un evento organizado en el marco del Día Mundial contra el Cáncer donde se darán a conocer las últimas innovaciones en materia de NANOMEDICINA contra el CÁNCER\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \n\n\n\nUn año más\, expertos en NANOMEDICINA de diferentes campos -investigadores\, empresarios\, médicos oncólogos\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la NANOMEDICINA significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer y como podemos contribuir en la misión Europea contra el cáncer. \n\n\n\nIniciado bajo el nombre de NANO WORLD CANCER DAY\, NANOMED Spain organiza la edición de este año de manera virtual con la colaboración del VHIR (Vall d’Hebron Instituto de Investigación) y el VHIO (Vall d’Hebron Instituto de Oncología).  \n\n\n\nMás información y registro aquí.
URL:https://ibecbarcelona.eu/event/nanodia-mundial-contra-el-cancer-2022/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220204T100000
DTEND;TZID=Europe/Madrid:20220204T130000
DTSTAMP:20220427T085709Z
CREATED:20220427T085707Z
LAST-MODIFIED:20220427T085709Z
UID:93899-1643968800-1643979600@ibecbarcelona.eu
SUMMARY:Nanodía mundial contra el cáncer – 2022
DESCRIPTION:El Nanodía Mundial Contra el Cáncer es un evento organizado en el marco del Día Mundial contra el Cáncer donde se darán a conocer las últimas innovaciones en materia de NANOMEDICINA contra el CÁNCER\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \n\n\n\nUn año más\, expertos en NANOMEDICINA de diferentes campos -investigadores\, empresarios\, médicos oncólogos\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la NANOMEDICINA significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer y como podemos contribuir en la misión Europea contra el cáncer. \n\n\n\nIniciado bajo el nombre de NANO WORLD CANCER DAY\, NANOMED Spain organiza la edición de este año de manera virtual con la colaboración del VHIR (Vall d’Hebron Instituto de Investigación) y el VHIO (Vall d’Hebron Instituto de Oncología).  \n\n\n\nMás información y registro aquí.
URL:https://ibecbarcelona.eu/event/nanodia-mundial-contra-el-cancer-2022/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220201T100000
DTEND;TZID=Europe/Madrid:20220201T120000
DTSTAMP:20220427T085101Z
CREATED:20220427T085100Z
LAST-MODIFIED:20220427T085101Z
UID:93896-1643709600-1643716800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Lucía Selfa Aspiroz
DESCRIPTION:Engineering human pluripotent stem cells to understand kidney development and disease\n\n\n\nLucía Selfa Aspiroz\, Pluripotency for organ regeneration group \n\n\n\nThis thesis defence will start at 10AM. If you wisth to attend to this PhD thesis defence\, you can join here via zoom.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lucia-selfa-aspiroz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220201T100000
DTEND;TZID=Europe/Madrid:20220201T120000
DTSTAMP:20220427T085100Z
CREATED:20220427T085100Z
LAST-MODIFIED:20220427T085100Z
UID:93897-1643709600-1643716800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Lucía Selfa Aspiroz
DESCRIPTION:Engineering human pluripotent stem cells to understand kidney development and disease\n\n\n\nLucía Selfa Aspiroz\, Pluripotency for organ regeneration group \n\n\n\nThis thesis defence will start at 10AM. If you wisth to attend to this PhD thesis defence\, you can join here via zoom.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lucia-selfa-aspiroz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220201T100000
DTEND;TZID=Europe/Madrid:20220201T120000
DTSTAMP:20220427T085100Z
CREATED:20220427T085100Z
LAST-MODIFIED:20220427T085100Z
UID:93898-1643709600-1643716800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Lucía Selfa Aspiroz
DESCRIPTION:Engineering human pluripotent stem cells to understand kidney development and disease\n\n\n\nLucía Selfa Aspiroz\, Pluripotency for organ regeneration group \n\n\n\nThis thesis defence will start at 10AM. If you wisth to attend to this PhD thesis defence\, you can join here via zoom.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lucia-selfa-aspiroz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220128T110000
DTEND;TZID=Europe/Madrid:20220128T130000
DTSTAMP:20220427T084624Z
CREATED:20220427T084623Z
LAST-MODIFIED:20220427T084624Z
UID:93893-1643367600-1643374800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Andrea García Lizarribar
DESCRIPTION:Development of tunable bioinks to fabricate 3D-printed in vitro models: a special focus on skeletal muscle models with potential applications in metabolic alteration studies\n\n\n\nAndrea García Lizarribar\, Nanobioengineering group \n\n\n\nThis thesis defence will be held online using the Teams App\, you can find the link here. You can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-andrea-garcia-lizarribar/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220128T110000
DTEND;TZID=Europe/Madrid:20220128T130000
DTSTAMP:20220427T084623Z
CREATED:20220427T084623Z
LAST-MODIFIED:20220427T084623Z
UID:93894-1643367600-1643374800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Andrea García Lizarribar
DESCRIPTION:Development of tunable bioinks to fabricate 3D-printed in vitro models: a special focus on skeletal muscle models with potential applications in metabolic alteration studies\n\n\n\nAndrea García Lizarribar\, Nanobioengineering group \n\n\n\nThis thesis defence will be held online using the Teams App\, you can find the link here. You can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-andrea-garcia-lizarribar/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220128T110000
DTEND;TZID=Europe/Madrid:20220128T130000
DTSTAMP:20220427T084623Z
CREATED:20220427T084623Z
LAST-MODIFIED:20220427T084623Z
UID:93895-1643367600-1643374800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Andrea García Lizarribar
DESCRIPTION:Development of tunable bioinks to fabricate 3D-printed in vitro models: a special focus on skeletal muscle models with potential applications in metabolic alteration studies\n\n\n\nAndrea García Lizarribar\, Nanobioengineering group \n\n\n\nThis thesis defence will be held online using the Teams App\, you can find the link here. You can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-andrea-garcia-lizarribar/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220127T110000
DTEND;TZID=Europe/Madrid:20220127T140000
DTSTAMP:20220114T095412Z
CREATED:20220114T093409Z
LAST-MODIFIED:20220114T095412Z
UID:89936-1643281200-1643292000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ariadna Marín Llauradó
DESCRIPTION:Mechanical stress in curved epithelia of designed size and shape\nAriadna Marín Llauradó\, Integrative cell and tissue dynamics group \nThe function of organs such as lungs\, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. How epithelial geometry emerges from mechanical stresses remains poorly understood. To address this question systematically\, here we engineered curved epithelial monolayers of controlled size and shape and mapped their state of stress. We designed pressurized epithelia with spherical\, rectangular and ellipsoidal cross-sections. We developed a computational approach to map the stress tensor these epithelia from the measured pressure and geometry\, without assumptions of material properties.  In epithelia with spherical cross-section spanning more than one order of magnitude in radius\, we show that stress increases with areal strain in a size-independent manner. In epithelia with rectangular and ellipsoidal cross-section we found pronounced stress anisotropies consistent with asymmetric distribution tractions measured at the cell-substrate contact line. Cells tended to align with the direction of maximum principal stress\, but this alignment was non-universal and increased with monolayer anisotropy. Our study establishes how the size and shape of an epithelium depends on luminal pressure and mechanical stress. \nThis thesis defence will take place at Auditori Antoni Caparrós\, located at the Parc Científic de Barcelona\, Tower D with limited capacity\, seats will be assigned on a first come first served basis. The defence will start at 11 AM.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ariadna-marin-llaurado/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220127T110000
DTEND;TZID=Europe/Madrid:20220127T140000
DTSTAMP:20220114T095350Z
CREATED:20220114T093409Z
LAST-MODIFIED:20220114T095350Z
UID:89934-1643281200-1643292000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ariadna Marín Llauradó
DESCRIPTION:Mechanical stress in curved epithelia of designed size and shape\nAriadna Marín Llauradó\, Integrative cell and tissue dynamics group \nThe function of organs such as lungs\, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. How epithelial geometry emerges from mechanical stresses remains poorly understood. To address this question systematically\, here we engineered curved epithelial monolayers of controlled size and shape and mapped their state of stress. We designed pressurized epithelia with spherical\, rectangular and ellipsoidal cross-sections. We developed a computational approach to map the stress tensor these epithelia from the measured pressure and geometry\, without assumptions of material properties.  In epithelia with spherical cross-section spanning more than one order of magnitude in radius\, we show that stress increases with areal strain in a size-independent manner. In epithelia with rectangular and ellipsoidal cross-section we found pronounced stress anisotropies consistent with asymmetric distribution tractions measured at the cell-substrate contact line. Cells tended to align with the direction of maximum principal stress\, but this alignment was non-universal and increased with monolayer anisotropy. Our study establishes how the size and shape of an epithelium depends on luminal pressure and mechanical stress. \nThis thesis defence will take place at Auditori Antoni Caparrós\, located at the Parc Científic de Barcelona\, Tower D with limited capacity\, seats will be assigned on a first come first served basis. The defence will start at 11 AM.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ariadna-marin-llaurado/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220127T110000
DTEND;TZID=Europe/Madrid:20220127T140000
DTSTAMP:20220114T095438Z
CREATED:20220114T093409Z
LAST-MODIFIED:20220114T095438Z
UID:89937-1643281200-1643292000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ariadna Marín Llauradó
DESCRIPTION:Mechanical stress in curved epithelia of designed size and shape\nAriadna Marín Llauradó\, Integrative cell and tissue dynamics group \nThe function of organs such as lungs\, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. How epithelial geometry emerges from mechanical stresses remains poorly understood. To address this question systematically\, here we engineered curved epithelial monolayers of controlled size and shape and mapped their state of stress. We designed pressurized epithelia with spherical\, rectangular and ellipsoidal cross-sections. We developed a computational approach to map the stress tensor these epithelia from the measured pressure and geometry\, without assumptions of material properties.  In epithelia with spherical cross-section spanning more than one order of magnitude in radius\, we show that stress increases with areal strain in a size-independent manner. In epithelia with rectangular and ellipsoidal cross-section we found pronounced stress anisotropies consistent with asymmetric distribution tractions measured at the cell-substrate contact line. Cells tended to align with the direction of maximum principal stress\, but this alignment was non-universal and increased with monolayer anisotropy. Our study establishes how the size and shape of an epithelium depends on luminal pressure and mechanical stress. \nThis thesis defence will take place at Auditori Antoni Caparrós\, located at the Parc Científic de Barcelona\, Tower D with limited capacity\, seats will be assigned on a first come first served basis. The defence will start at 11 AM.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ariadna-marin-llaurado/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220122T040000
DTEND;TZID=Europe/Madrid:20220122T173000
DTSTAMP:20220427T084206Z
CREATED:20220427T084206Z
LAST-MODIFIED:20220427T084206Z
UID:93891-1642824000-1642872600@ibecbarcelona.eu
SUMMARY:Núria Montserrat at "TEDxBarcelona - 8+3 charlas para vivir una vida saludable"
DESCRIPTION:Evento anual TEDxBarcelona 2022\, una jornada única donde personas extraordinarias presentarán sus ideas para vivir una vida en salud. \n\n\n\nEl evento anual consta de diferentes conferencias divididas en dos sesiones durante toda la jornada\, entre ellas\, los asistentes podrán disfrutar de una feria donde algunas empresas de Barcelona presentarán sus productos innovadores.1ª Ponencia: 16:00h – 17:30h \n\n\n\nJosé Cruset (Director de TEDxBarcelona)Chris Anderson (Curator at TED)Nuria Montserrat (ICREA Research Professor)Violeta Moizé (Profesora asociada de la UB en nutrición)Anneke Stolk (Cofundadora de Instagreen)Carlos Gonzalez y Neus Carol Gres (Proyecto AFIN)Feria y vídeos TED: 17:30h – 18:30h \n\n\n\nDan Buettner (How To Live To Be 100+)Jaime Oliver (Teach Every Child About Food)Tim Urban (Inside the mind of master procrastinator)2ª Ponencia: 18:30h – 20:00h \n\n\n\nChris Anderson (Curator at TED)Carol Blázquez (Directora de innovación y sostenibilidad en ECOALF)Lucía Hernández (Consultora para la ONU)Carlos Alcoba (Presidente de SostreCivic)María Hernández-Alcalá (CEO de Futurlife21) \n\n\n\nEntradas aquí
URL:https://ibecbarcelona.eu/event/nuria-montserrat-at-tedxbarcelona-83-charlas-para-vivir-una-vida-saludable/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220122T040000
DTEND;TZID=Europe/Madrid:20220122T173000
DTSTAMP:20220427T084207Z
CREATED:20220427T084206Z
LAST-MODIFIED:20220427T084207Z
UID:93890-1642824000-1642872600@ibecbarcelona.eu
SUMMARY:Núria Montserrat at "TEDxBarcelona - 8+3 charlas para vivir una vida saludable"
DESCRIPTION:Evento anual TEDxBarcelona 2022\, una jornada única donde personas extraordinarias presentarán sus ideas para vivir una vida en salud. \n\n\n\nEl evento anual consta de diferentes conferencias divididas en dos sesiones durante toda la jornada\, entre ellas\, los asistentes podrán disfrutar de una feria donde algunas empresas de Barcelona presentarán sus productos innovadores.1ª Ponencia: 16:00h – 17:30h \n\n\n\nJosé Cruset (Director de TEDxBarcelona)Chris Anderson (Curator at TED)Nuria Montserrat (ICREA Research Professor)Violeta Moizé (Profesora asociada de la UB en nutrición)Anneke Stolk (Cofundadora de Instagreen)Carlos Gonzalez y Neus Carol Gres (Proyecto AFIN)Feria y vídeos TED: 17:30h – 18:30h \n\n\n\nDan Buettner (How To Live To Be 100+)Jaime Oliver (Teach Every Child About Food)Tim Urban (Inside the mind of master procrastinator)2ª Ponencia: 18:30h – 20:00h \n\n\n\nChris Anderson (Curator at TED)Carol Blázquez (Directora de innovación y sostenibilidad en ECOALF)Lucía Hernández (Consultora para la ONU)Carlos Alcoba (Presidente de SostreCivic)María Hernández-Alcalá (CEO de Futurlife21) \n\n\n\nEntradas aquí
URL:https://ibecbarcelona.eu/event/nuria-montserrat-at-tedxbarcelona-83-charlas-para-vivir-una-vida-saludable/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220122T040000
DTEND;TZID=Europe/Madrid:20220122T173000
DTSTAMP:20220427T084206Z
CREATED:20220427T084206Z
LAST-MODIFIED:20220427T084206Z
UID:93892-1642824000-1642872600@ibecbarcelona.eu
SUMMARY:Núria Montserrat at "TEDxBarcelona - 8+3 charlas para vivir una vida saludable"
DESCRIPTION:Evento anual TEDxBarcelona 2022\, una jornada única donde personas extraordinarias presentarán sus ideas para vivir una vida en salud. \n\n\n\nEl evento anual consta de diferentes conferencias divididas en dos sesiones durante toda la jornada\, entre ellas\, los asistentes podrán disfrutar de una feria donde algunas empresas de Barcelona presentarán sus productos innovadores.1ª Ponencia: 16:00h – 17:30h \n\n\n\nJosé Cruset (Director de TEDxBarcelona)Chris Anderson (Curator at TED)Nuria Montserrat (ICREA Research Professor)Violeta Moizé (Profesora asociada de la UB en nutrición)Anneke Stolk (Cofundadora de Instagreen)Carlos Gonzalez y Neus Carol Gres (Proyecto AFIN)Feria y vídeos TED: 17:30h – 18:30h \n\n\n\nDan Buettner (How To Live To Be 100+)Jaime Oliver (Teach Every Child About Food)Tim Urban (Inside the mind of master procrastinator)2ª Ponencia: 18:30h – 20:00h \n\n\n\nChris Anderson (Curator at TED)Carol Blázquez (Directora de innovación y sostenibilidad en ECOALF)Lucía Hernández (Consultora para la ONU)Carlos Alcoba (Presidente de SostreCivic)María Hernández-Alcalá (CEO de Futurlife21) \n\n\n\nEntradas aquí
URL:https://ibecbarcelona.eu/event/nuria-montserrat-at-tedxbarcelona-83-charlas-para-vivir-una-vida-saludable/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220121T100000
DTEND;TZID=Europe/Madrid:20220121T120000
DTSTAMP:20220111T080313Z
CREATED:20210901T151240Z
LAST-MODIFIED:20220111T080313Z
UID:86926-1642759200-1642766400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Carlos Aleman
DESCRIPTION:Smart and multifunctional artificial materials for bioengineering\nCarlos Aleman\, Universitat Politècnica de Catalunta (UPC) \nThe research of the ” Innovation\, Modeling & Engineering in Materials” group in the field of multifunctional materials. Three\, different examples of multifunctional systems will be presented: 1) Magnetic electroconductive and self-healing PEDOT:alginate hydrogels for sensing\, drug-delivery and energy storage; 2) Self-standing PLA/PEDOT films as artificial muscles\, controlled lactate release and selective ion transport; and 3) Permanently polarized hydroxyapatite a biocatalyst for carbon and nitrogen fixation. \nCarlos Alemán graduated in Chemistry from the University of Barcelona (Spain). He received his Ph.D. from the Polytechnic University of Catalonia (UPC) in 1994\, where he was promoted to the position of Full Professor of Physical Chemistry. He was postdoctoral researcher at the ETH in Zürich (Switzerland) and visiting professor at the Università di Napoli Federico II (Italy)\, University of Twente (Holland) and Universidade Federal do Rio Grande do Sul (Brazil). Since 2003 he is the leader of the ‘‘Innovation\, Modeling & Engineering in Materials’’ (IMEM) group. His main research interests focus on conducting polymers and biopolymers with biomedical and technological (energy) applications. \nThis seminar will take place online\, using the go to meeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-carlos-aleman/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220121T100000
DTEND;TZID=Europe/Madrid:20220121T120000
DTSTAMP:20220111T080516Z
CREATED:20210901T151240Z
LAST-MODIFIED:20220111T080516Z
UID:86928-1642759200-1642766400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Carlos Alemán
DESCRIPTION:Smart and multifunctional artificial materials for bioengineering\nCarlos Alemán\, Universitat Politècnica de Catalunta (UPC) \nThe research of the ” Innovation\, Modeling & Engineering in Materials” group in the field of multifunctional materials. Three\, different examples of multifunctional systems will be presented: 1) Magnetic electroconductive and self-healing PEDOT:alginate hydrogels for sensing\, drug-delivery and energy storage; 2) Self-standing PLA/PEDOT films as artificial muscles\, controlled lactate release and selective ion transport; and 3) Permanently polarized hydroxyapatite a biocatalyst for carbon and nitrogen fixation. \nCarlos Alemán graduated in Chemistry from the University of Barcelona (Spain). He received his Ph.D. from the Polytechnic University of Catalonia (UPC) in 1994\, where he was promoted to the position of Full Professor of Physical Chemistry. He was postdoctoral researcher at the ETH in Zürich (Switzerland) and visiting professor at the Università di Napoli Federico II (Italy)\, University of Twente (Holland) and Universidade Federal do Rio Grande do Sul (Brazil). Since 2003 he is the leader of the ‘‘Innovation\, Modeling & Engineering in Materials’’ (IMEM) group. His main research interests focus on conducting polymers and biopolymers with biomedical and technological (energy) applications. \nThis seminar will take place online\, using the go to meeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-carlos-aleman/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220121T100000
DTEND;TZID=Europe/Madrid:20220121T120000
DTSTAMP:20220111T080559Z
CREATED:20210901T151240Z
LAST-MODIFIED:20220111T080559Z
UID:86929-1642759200-1642766400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Carlos Alemán
DESCRIPTION:Smart and multifunctional artificial materials for bioengineering\nCarlos Alemán\, Universitat Politècnica de Catalunta (UPC) \nThe research of the ” Innovation\, Modeling & Engineering in Materials” group in the field of multifunctional materials. Three\, different examples of multifunctional systems will be presented: 1) Magnetic electroconductive and self-healing PEDOT:alginate hydrogels for sensing\, drug-delivery and energy storage; 2) Self-standing PLA/PEDOT films as artificial muscles\, controlled lactate release and selective ion transport; and 3) Permanently polarized hydroxyapatite a biocatalyst for carbon and nitrogen fixation. \nCarlos Alemán graduated in Chemistry from the University of Barcelona (Spain). He received his Ph.D. from the Polytechnic University of Catalonia (UPC) in 1994\, where he was promoted to the position of Full Professor of Physical Chemistry. He was postdoctoral researcher at the ETH in Zürich (Switzerland) and visiting professor at the Università di Napoli Federico II (Italy)\, University of Twente (Holland) and Universidade Federal do Rio Grande do Sul (Brazil). Since 2003 he is the leader of the ‘‘Innovation\, Modeling & Engineering in Materials’’ (IMEM) group. His main research interests focus on conducting polymers and biopolymers with biomedical and technological (energy) applications. \nThis seminar will take place online\, using the go to meeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-carlos-aleman/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220112T113000
DTEND;TZID=Europe/Madrid:20220112T133000
DTSTAMP:20220104T125256Z
CREATED:20220104T125256Z
LAST-MODIFIED:20220104T125256Z
UID:89873-1641987000-1641994200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana López Mengual
DESCRIPTION:Factores físicos y moleculares implicados en la migración celular y en el desarrollo de la corteza cerebral.\nAna López Mengual\, Molecular and cellular neurobiotechnology group \nAbstract \nCell migration acquires special relevance during embryonic development and tissue regeneration. During the development of the adult individual\, cells multiply\, differentiate and mature\, having to move to their destination regions through migration. Once the adult individual has formed\, these tissues can suffer damage\, leading to an altered state. In this process of tissue regeneration\, they try to set tissue homeostasis\, cell migration is essential. This thesis analyses the mechanical factors involved in cell migration in brain development and neural regeneration\, as a fundamental tool to understand these processes. OECs migrate greater distances over CXCL12 functionalized PLA 80/20 nanofibers\, thus responding to the chemotactic gradient. Measurements made with by means of BIO-AFM of the mouse embryonic brain reveals differences between the pallium and the subpallium. These differences determine the differential migration rates when transplanting explants of various origins outside their usual site and analysing the migration of Cajal-Retzius cells. In addition\, Cajal-Retzius cells respond by calcium entry to the inhibition of mechanosensitive cation channels\, changing their migration rate. So\, we conclude that physical factors are a key factor involved in the migration and disposition of Cajal-Retzius cells. \n  \n\n  \n  \nThe public event will take place in the Sala de Graus of the Faculty of Biology of the UB on January 12 at 11:30. If you prefer to attend to this defence virtually\, contact with Ana López (alopezm@ibecbarcelona.eu) and she will send you the link of the defence and the instructions. \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-lopez-mengual/
LOCATION:Sala Graus\, Faculty of Biology\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220112T113000
DTEND;TZID=Europe/Madrid:20220112T133000
DTSTAMP:20220104T132247Z
CREATED:20220104T125256Z
LAST-MODIFIED:20220104T132247Z
UID:89869-1641987000-1641994200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana López Mengual
DESCRIPTION:Factores físicos y moleculares implicados en la migración celular y en el desarrollo de la corteza cerebral.\nAna López Mengual\, Molecular and cellular neurobiotechnology group \nAbstract \nCell migration acquires special relevance during embryonic development and tissue regeneration. During the development of the adult individual\, cells multiply\, differentiate and mature\, having to move to their destination regions through migration. Once the adult individual has formed\, these tissues can suffer damage\, leading to an altered state. In this process of tissue regeneration\, they try to set tissue homeostasis\, cell migration is essential. This thesis analyses the mechanical factors involved in cell migration in brain development and neural regeneration\, as a fundamental tool to understand these processes. OECs migrate greater distances over CXCL12 functionalized PLA 80/20 nanofibers\, thus responding to the chemotactic gradient. Measurements made with by means of BIO-AFM of the mouse embryonic brain reveals differences between the pallium and the subpallium. These differences determine the differential migration rates when transplanting explants of various origins outside their usual site and analysing the migration of Cajal-Retzius cells. In addition\, Cajal-Retzius cells respond by calcium entry to the inhibition of mechanosensitive cation channels\, changing their migration rate. So\, we conclude that physical factors are a key factor involved in the migration and disposition of Cajal-Retzius cells. \n  \n\n  \n  \nThe public event will take place at the Sala de Graus at the Faculty of Biology (University of Barcelona) on January 12th at 11:30. If you prefer to attend to this defence virtually\, contact with Ana López (alopezm@ibecbarcelona.eu). \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-lopez-mengual/
LOCATION:Sala Graus\, Faculty of Biology\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220112T113000
DTEND;TZID=Europe/Madrid:20220112T133000
DTSTAMP:20220104T125256Z
CREATED:20220104T125256Z
LAST-MODIFIED:20220104T125256Z
UID:89872-1641987000-1641994200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana López Mengual
DESCRIPTION:Factores físicos y moleculares implicados en la migración celular y en el desarrollo de la corteza cerebral.\nAna López Mengual\, Molecular and cellular neurobiotechnology group \nAbstract \nCell migration acquires special relevance during embryonic development and tissue regeneration. During the development of the adult individual\, cells multiply\, differentiate and mature\, having to move to their destination regions through migration. Once the adult individual has formed\, these tissues can suffer damage\, leading to an altered state. In this process of tissue regeneration\, they try to set tissue homeostasis\, cell migration is essential. This thesis analyses the mechanical factors involved in cell migration in brain development and neural regeneration\, as a fundamental tool to understand these processes. OECs migrate greater distances over CXCL12 functionalized PLA 80/20 nanofibers\, thus responding to the chemotactic gradient. Measurements made with by means of BIO-AFM of the mouse embryonic brain reveals differences between the pallium and the subpallium. These differences determine the differential migration rates when transplanting explants of various origins outside their usual site and analysing the migration of Cajal-Retzius cells. In addition\, Cajal-Retzius cells respond by calcium entry to the inhibition of mechanosensitive cation channels\, changing their migration rate. So\, we conclude that physical factors are a key factor involved in the migration and disposition of Cajal-Retzius cells. \n  \n\n  \n  \nThe public event will take place in the Sala de Graus of the Faculty of Biology of the UB on January 12 at 11:30. If you prefer to attend to this defence virtually\, contact with Ana López (alopezm@ibecbarcelona.eu) and she will send you the link of the defence and the instructions. \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-lopez-mengual/
LOCATION:Sala Graus\, Faculty of Biology\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211217T100000
DTEND;TZID=Europe/Madrid:20211217T120000
DTSTAMP:20211209T122951Z
CREATED:20210909T094506Z
LAST-MODIFIED:20211209T122951Z
UID:87091-1639735200-1639742400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Enrico Almici and Albert Manzano
DESCRIPTION:Investigating Pathological Extracellular Matrix Architecture\nThe composition and architecture of the extracellular matrix (ECM)\, and their dynamic alterations\, play an important regulatory role on numerous cellular processes. Furthermore\, structural and biochemical properties of the ECM are central in regulating cell behavior via mechanical\, chemical and topological cues detected by receptors in the cell membrane which induce cytoskeleton rearrangement and/or cell nucleus gene expression. Indeed\, distinct ECM architectures are encountered in the native stroma\, which depend on tissue type\, function and composition. For instance\, ECM anisotropy and stiffness are associated with altered ECM degradation and remodeling in cancer. In turn\, this architecture favors tumor progression and invasion. Moreover\, numerous diseases are associated with mutations in genes encoding ECM components\, leading to deficient mechanical properties and altered ECM structure. Thus\, there is an increasing interest to exploit and consolidate this knowledge to improve patients’ treatment and care. In my work I focused on Collagen-VI related muscular dystrophies and Non-small cell lung cancer\, to investigate in vitro and in patient tissues ECM-related biomarkers to be implemented in clinical setting. I employed automatic image segmentation to quantify fibrillar characteristics and investigate the association with the clinicopathological information from patients. Ultimately this analysis along with the tools presented is promising for addressing the need of novel descriptors\, to stratify patients and evaluate their response to experimental treatments. \nEnrico Almici\, Nanobioengineering \nPersonalizing pediatric leukemia treatment using cell-based functional assays and microfluidics\nCancer personalized medicine improves treatment by testing different drugs in samples from every individual patient to select the best option in every case\, maximizing efficacy and reducing side effects. Pediatric B-cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) has an acceptable cure rate\, however\, almost 10% of the cases are refractory to standard-of-care treatments\, showing an urgent need for new therapeutic options. Here\, we use Dynamic BH3 Profiling (DBP)\, a new assay that uses synthetic peptides mimicking the pro-apoptotic effect of the BH3 family of proteins\, to predict treatment efficacy and anti-apoptotic adaptations conferring treatment resistance. Applying DBP in two BCP-ALL cell lines we identified new treatment options including both targeted agents and chemotherapies. We were also able to describe the mechanistic response of these cells after treatment\, which acquired resistance using anti-apoptotic proteins that were later overcome using specific inhibitors called BH3 mimetics. Importantly\, this resistance mechanism was also seen in patient-derived xenografts opening the use of these new combinations with BH3 mimetics in BCP-ALL patients. In the second part of the presentation\, we developed a new version of the DBP protocol. Actual cytometry-based DBP requires a large number of viable cells which are easily obtained in liquid tumors but not in solid tumor biopsies\, limiting the number of treatments that can be explored. To solve this problem\, we developed a microfluidic-based DBP that drastically reduces cell requirement to perform the assay and helps to automatize the process to be implemented as a routinely clinical technique. We validated this microfluidic-based DBP using two gastrointestinal stromal tumor (GIST) cell lines obtaining similar results between the new protocol and the cytometry-based DBP. Finally\, we used a primary GIST sample to identify a treatment combination that induced apoptosis to these patient cells\, which proves that the microfluidic-based DBP can help to personalize solid cancers treatment. \nAlbert Manzano\, Nanobioengineering \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/phd-discussions-enrico-almici-and-giulia-fornabaio/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211217T100000
DTEND;TZID=Europe/Madrid:20211217T120000
DTSTAMP:20211209T123134Z
CREATED:20210909T094506Z
LAST-MODIFIED:20211209T123134Z
UID:87093-1639735200-1639742400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Enrico Almici and Albert Manzano
DESCRIPTION:Investigating Pathological Extracellular Matrix Architecture\nThe composition and architecture of the extracellular matrix (ECM)\, and their dynamic alterations\, play an important regulatory role on numerous cellular processes. Furthermore\, structural and biochemical properties of the ECM are central in regulating cell behavior via mechanical\, chemical and topological cues detected by receptors in the cell membrane which induce cytoskeleton rearrangement and/or cell nucleus gene expression. Indeed\, distinct ECM architectures are encountered in the native stroma\, which depend on tissue type\, function and composition. For instance\, ECM anisotropy and stiffness are associated with altered ECM degradation and remodeling in cancer. In turn\, this architecture favors tumor progression and invasion. Moreover\, numerous diseases are associated with mutations in genes encoding ECM components\, leading to deficient mechanical properties and altered ECM structure. Thus\, there is an increasing interest to exploit and consolidate this knowledge to improve patients’ treatment and care. In my work I focused on Collagen-VI related muscular dystrophies and Non-small cell lung cancer\, to investigate in vitro and in patient tissues ECM-related biomarkers to be implemented in clinical setting. I employed automatic image segmentation to quantify fibrillar characteristics and investigate the association with the clinicopathological information from patients. Ultimately this analysis along with the tools presented is promising for addressing the need of novel descriptors\, to stratify patients and evaluate their response to experimental treatments. \nEnrico Almici\, Nanobioengineering \nPersonalizing pediatric leukemia treatment using cell-based functional assays and microfluidics\nCancer personalized medicine improves treatment by testing different drugs in samples from every individual patient to select the best option in every case\, maximizing efficacy and reducing side effects. Pediatric B-cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) has an acceptable cure rate\, however\, almost 10% of the cases are refractory to standard-of-care treatments\, showing an urgent need for new therapeutic options. Here\, we use Dynamic BH3 Profiling (DBP)\, a new assay that uses synthetic peptides mimicking the pro-apoptotic effect of the BH3 family of proteins\, to predict treatment efficacy and anti-apoptotic adaptations conferring treatment resistance. Applying DBP in two BCP-ALL cell lines we identified new treatment options including both targeted agents and chemotherapies. We were also able to describe the mechanistic response of these cells after treatment\, which acquired resistance using anti-apoptotic proteins that were later overcome using specific inhibitors called BH3 mimetics. Importantly\, this resistance mechanism was also seen in patient-derived xenografts opening the use of these new combinations with BH3 mimetics in BCP-ALL patients. In the second part of the presentation\, we developed a new version of the DBP protocol. Actual cytometry-based DBP requires a large number of viable cells which are easily obtained in liquid tumors but not in solid tumor biopsies\, limiting the number of treatments that can be explored. To solve this problem\, we developed a microfluidic-based DBP that drastically reduces cell requirement to perform the assay and helps to automatize the process to be implemented as a routinely clinical technique. We validated this microfluidic-based DBP using two gastrointestinal stromal tumor (GIST) cell lines obtaining similar results between the new protocol and the cytometry-based DBP. Finally\, we used a primary GIST sample to identify a treatment combination that induced apoptosis to these patient cells\, which proves that the microfluidic-based DBP can help to personalize solid cancers treatment. \nAlbert Manzano\, Nanobioengineering \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/phd-discussions-enrico-almici-and-giulia-fornabaio/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211217T100000
DTEND;TZID=Europe/Madrid:20211217T120000
DTSTAMP:20211209T123245Z
CREATED:20210909T094506Z
LAST-MODIFIED:20211209T123245Z
UID:87094-1639735200-1639742400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Enrico Almici and Albert Manzano
DESCRIPTION:Investigating Pathological Extracellular Matrix Architecture\nThe composition and architecture of the extracellular matrix (ECM)\, and their dynamic alterations\, play an important regulatory role on numerous cellular processes. Furthermore\, structural and biochemical properties of the ECM are central in regulating cell behavior via mechanical\, chemical and topological cues detected by receptors in the cell membrane which induce cytoskeleton rearrangement and/or cell nucleus gene expression. Indeed\, distinct ECM architectures are encountered in the native stroma\, which depend on tissue type\, function and composition. For instance\, ECM anisotropy and stiffness are associated with altered ECM degradation and remodeling in cancer. In turn\, this architecture favors tumor progression and invasion. Moreover\, numerous diseases are associated with mutations in genes encoding ECM components\, leading to deficient mechanical properties and altered ECM structure. Thus\, there is an increasing interest to exploit and consolidate this knowledge to improve patients’ treatment and care. In my work I focused on Collagen-VI related muscular dystrophies and Non-small cell lung cancer\, to investigate in vitro and in patient tissues ECM-related biomarkers to be implemented in clinical setting. I employed automatic image segmentation to quantify fibrillar characteristics and investigate the association with the clinicopathological information from patients. Ultimately this analysis along with the tools presented is promising for addressing the need of novel descriptors\, to stratify patients and evaluate their response to experimental treatments. \nEnrico Almici\, Nanobioengineering \nPersonalizing pediatric leukemia treatment using cell-based functional assays and microfluidics\nCancer personalized medicine improves treatment by testing different drugs in samples from every individual patient to select the best option in every case\, maximizing efficacy and reducing side effects. Pediatric B-cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) has an acceptable cure rate\, however\, almost 10% of the cases are refractory to standard-of-care treatments\, showing an urgent need for new therapeutic options. Here\, we use Dynamic BH3 Profiling (DBP)\, a new assay that uses synthetic peptides mimicking the pro-apoptotic effect of the BH3 family of proteins\, to predict treatment efficacy and anti-apoptotic adaptations conferring treatment resistance. Applying DBP in two BCP-ALL cell lines we identified new treatment options including both targeted agents and chemotherapies. We were also able to describe the mechanistic response of these cells after treatment\, which acquired resistance using anti-apoptotic proteins that were later overcome using specific inhibitors called BH3 mimetics. Importantly\, this resistance mechanism was also seen in patient-derived xenografts opening the use of these new combinations with BH3 mimetics in BCP-ALL patients. In the second part of the presentation\, we developed a new version of the DBP protocol. Actual cytometry-based DBP requires a large number of viable cells which are easily obtained in liquid tumors but not in solid tumor biopsies\, limiting the number of treatments that can be explored. To solve this problem\, we developed a microfluidic-based DBP that drastically reduces cell requirement to perform the assay and helps to automatize the process to be implemented as a routinely clinical technique. We validated this microfluidic-based DBP using two gastrointestinal stromal tumor (GIST) cell lines obtaining similar results between the new protocol and the cytometry-based DBP. Finally\, we used a primary GIST sample to identify a treatment combination that induced apoptosis to these patient cells\, which proves that the microfluidic-based DBP can help to personalize solid cancers treatment. \nAlbert Manzano\, Nanobioengineering \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/phd-discussions-enrico-almici-and-giulia-fornabaio/
CATEGORIES:PhD Discussions Session
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DTSTART;TZID=Europe/Madrid:20211210T100000
DTEND;TZID=Europe/Madrid:20211210T120000
DTSTAMP:20211129T105907Z
CREATED:20210901T150722Z
LAST-MODIFIED:20211129T105907Z
UID:86924-1639130400-1639137600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Irene Marco
DESCRIPTION:Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Molecular Imaging for Precision Medicine group at IBEC \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease. \nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time.  Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo. Also\, I will talk about the progress we have made at IBEC in the past couple of months and how we plan to implement HP MR to monitor metabolism in organs-in-chips. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Irene Marco’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-irene-marco/
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211210T100000
DTEND;TZID=Europe/Madrid:20211210T120000
DTSTAMP:20211129T105930Z
CREATED:20210901T150722Z
LAST-MODIFIED:20211129T105930Z
UID:86925-1639130400-1639137600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Irene Marco
DESCRIPTION:Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Molecular Imaging for Precision Medicine group at IBEC \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease. \nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time.  Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo. Also\, I will talk about the progress we have made at IBEC in the past couple of months and how we plan to implement HP MR to monitor metabolism in organs-in-chips. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Irene Marco’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-irene-marco/
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211210T100000
DTEND;TZID=Europe/Madrid:20211210T120000
DTSTAMP:20211129T105836Z
CREATED:20210901T150722Z
LAST-MODIFIED:20211129T105836Z
UID:86922-1639130400-1639137600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Irene Marco
DESCRIPTION:Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Molecular Imaging for Precision Medicine group at IBEC \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease. \nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time.  Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo. Also\, I will talk about the progress we have made at IBEC in the past couple of months and how we plan to implement HP MR to monitor metabolism in organs-in-chips. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Irene Marco’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-irene-marco/
CATEGORIES:IBEC Seminar
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