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DTSTART;TZID=Europe/Madrid:20260126T160000
DTEND;TZID=Europe/Madrid:20260126T170000
DTSTAMP:20260404T001138
CREATED:20260108T111446Z
LAST-MODIFIED:20260108T111446Z
UID:131221-1769443200-1769446800@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Silke Henkes
DESCRIPTION:Mechanochemical feedback in model epithelial tissues\nSilke Henkes\, Leiden Institute of Physics\, Leiden University \nIn the development of animals\, tissues self-organise starting from a single cell into layers\, shapes and patterns. This active mechanical process operates beyond the theoretical framework of reaction-diffusion equations such as Turing patterns. At the same time\, combining active driving with careful mechanical design of a system is distinct route to pattern formation and artificial functionality. \nHere I will show how two types of active driving interacts with mechanics: First\, for polar active materials where cells crawl on a substrate\, even with only uncorrelated activity\, elasticity leads to\nthe emergence of mesoscopic space-time correlations. I will show how this explains the ‘fingering instability’ at the edge of MDCK epithelial cell sheets as long lived active correlations. If we add alignment to generate a flocking state\, and cell division and death\, we model corneal epithelial cells well. We are then able to simulate the whole curved corneal epithelium\, and show that an inflow of cells from the limbus generates a stable spiral flow pattern with a +1 topological defect at the centre. \nSecond\, mechanochemical stress feedback in cell-cell junctions arises from the catch bond dynamics of the actomyosin cortex. It allows a junction to generate a contractile force that can overcome external pulling and thus allow for an active rearrangement or T1. In vertex and continuum models\, for strong enough feedback this gives rise to convergence-extension flows where the flow is opposite the direction of mechanical polarisation\, effectively generating a negative viscosity state.
URL:https://ibecbarcelona.eu/event/ibec-seminar-silke-henkes/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260130T093000
DTEND;TZID=Europe/Madrid:20260130T103000
DTSTAMP:20260404T001138
CREATED:20251211T145452Z
LAST-MODIFIED:20251211T145452Z
UID:130855-1769765400-1769769000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Francisco Lorenzo-Martín
DESCRIPTION:Next-generation organoid models for colorectal cancer research\nFrancisco Lorenzo-Martín\, University of Salamanca \n\nThree-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of tumor structures. This has enabled better modelling of low-complexity cancer cell behaviors that occur over short periods of time. However\, the currently available organoid systems lack the requisite multi-cellular diversity\, tissue-level organization\, biological durability\, and experimental flexibility that are needed to capture complex oncological processes. Consequently\, the study of many multifactorial cancer mechanisms is still not possible in vitro and instead requires the extensive use of animal models\, which provide limited spatiotemporal resolution of cellular dynamics and come at a substantial ethical cost. To overcome these limitations\, we have implemented tissue engineering and microfabrication technologies to develop topobiologically complex ex vivo cancer avatars. Focusing on colorectal cancer\, we have generated miniature tissues consisting of long-lived gut-shaped colon epithelia (‘mini-colons’) that are able to undergo tumorigenesis in vitro and stably integrate cancer cells with their native tumor microenvironment. This system provides an unprecedented repertoire of experimental possibilities\, which we illustrate through diverse applications. Altogether\, these next-generation organoid models push the boundaries of ex vivo cancer research.
URL:https://ibecbarcelona.eu/event/ibec-seminar-francisco-lorenzo-martin/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260203T100000
DTEND;TZID=Europe/Madrid:20260203T150000
DTSTAMP:20260404T001138
CREATED:20260119T133250Z
LAST-MODIFIED:20260128T132855Z
UID:131528-1770112800-1770130800@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Prof. Pierangelo Gobbo
DESCRIPTION:A search for the right scientific question: can we fabricate cells and tissues from scratch?\nProf. Pierangelo Gobbo\, University of Trieste \nBottom-up synthetic biology is an emerging research field whose objectives is to design and fabricate existing biological systems from inanimate molecules\, materials\, and chemical reactions.[1] One of the key biological systems that bottom-up synthetic biology is trying to re-design and fabricate is the living cell. This research led to the concept of “protocell” and “prototissues”.[2] A protocell is a micro-compartmentalised system capable of imitating at least one of the key features of a living cell (e.g.\, enzyme catalysis\, communication based on diffusible chemical signals\, information storage etc.). A prototissue is instead a free-standing and covalently interconnected network of communicating protocell units that can display synergistic functions.[3\, 4] \nWhile thus far efforts have been placed in the development of methods to fabricate PCMs with complex 3D architectures and demonstrate their chemical communication properties\, in this contribution I will show how I used the knowledge acquired during my entire scientific journey to move beyond the state-of-the-art in bottom-up synthetic biology\, and develop the first prototissues capable of photo-mechano-chemical transduction.[5] These are prototissues capable of converting a light stimulus into complex mechanical movements that in turn can influence the biocatalysis hosted within the protocell units composing the material itself. In order to achieve this\, we have designed and assembled a covalent and thermoresponsive poly(N-isopropylacrylamide) (P(NIPAM)) polymer network directly inside the lumen of the protocells composing the PCM\, where we also placed poly(ethylene oxide) (PEG) stabilised gold nanoparticles (AuNPs)\, amyloglucosidase (AGx)\, and glucose oxidase (GOx). By exploiting the photo-thermal effect of AuNPs and the thermoresponsive properties of the PNIPAM network in a synergistic manner\, we were able to achieve reversible light-induced contractions of the PCM. Most importantly\, the contraction caused the material to become hydrophobic. This made the contracted protocell membranes impermeable to small hydrophilic substrate molecules for enzyme catalysis\, and effectively shut off the hosted enzyme cascade. \nThe fabrication of tissue-like materials with increasingly advanced biomimetic properties will not only help us to understand the physicochemical basis of the emerging behaviours of living tissues\, but will also find important applications in tissue engineering\, pharmacokinetics\, mechanobiology\, personalised therapy\, in the development of micro-bioreactors and soft robotics. \nPierangelo Gobbo received his BSc (2008) and MSc (2010) in Chemistry at the University of Padua (Italy) and his PhD in 2016 at the University of Western Ontario (Canada). In 2016 he joined the research group of Prof. Stephen Mann\, FRS at the University of Bristol (UK) as an NSERC of Canada Postdoctoral Fellow first\, and then as an EU Marie Curie Postdoctoral Fellow. In 2019 Pierangelo started his independent research career at the School of Chemistry of the University of Bristol under a Vice-Chancellor’s Fellowship (Assistant Professorship). In October 2021 Pierangelo moved to the Department of Chemical and Pharmaceutical Sciences of the University of Trieste (Italy) where he is pioneering the first strategies to use synthetic cells (or “protocells”) as foundational units to assemble free-standing tissue-like materials with complex 3D architectures and programmable bio-inspired emergent behaviours such as contractility\, phototropism\, and biochemical sensing. During his academic career Pierangelo was awarded numerous awards for excellence in research. The most recent are Italy’s Giacomo Ciamician Medal for Organic Chemistry (2021)\, UK’s EPSRC New Investigator Award (2020)\, and the Canada’s Governor General’s Gold Medal (2017). He is currently PI on an ERC Starting Grant 2021\, co-coordinator of an EIC Pathfinder Open 2022\, and the coordinator of other National research projects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-pierangelo-gobbo/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260203T123000
DTEND;TZID=Europe/Madrid:20260203T170000
DTSTAMP:20260404T001138
CREATED:20260114T142056Z
LAST-MODIFIED:20260119T141340Z
UID:131306-1770121800-1770138000@ibecbarcelona.eu
SUMMARY:Nano Cancer Day
DESCRIPTION:El Nanodía Mundial Contra el Cáncer es un evento organizado en el marco del Día Mundial contra el Cáncer donde se darán a conocer las últimas innovaciones en materia de NANOMEDICINA contra el CÁNCER\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o la radioterapia con nanopartículas. \nUn año más\, expertos en NANOMEDICINA de diferentes campos -investigadores\, empresarios\, médicos oncólogos\, pacientes\, etc.\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la NANOMEDICINA significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento del cáncer y como podemos contribuir en la misión Europea contra el cáncer. \nNANOMED Spain organiza la edición de este año con el Hospital del Mar Research Institute Barcelona \n  \n\n\n\n09:30\nBienvenida e Inauguración · \nJosep Samitier · Coordinador Científico de NANOMED Spain\nJoaquín Arribas · Director del Hospital del Mar Research Institute Barcelona (HMRIB)\n\n\n09:40\nNanomedicina y cáncer \nJosep Samitier · Coordinador Científico de NANOMED Spain\n\n\n10:00\nIniciativa en terapias avanzadas: Programa de Terapia Celular y sustancias de Origen Humano\nLuís Álvarez Vallina · Director del Programa de Terapia Celular y Sustancias de Origen Humano del Hospital del Mar Research Institute Barcelona (HMRIB) y director de Investigación del Banco de Sangre y Tejidos (BST)\n\n\n10:25\nTBC\n\n\n10:50\nCafé\n\n\n11:25\nPlataformas y Capacidades para la fabricación de Terapias avanzadas de uso clínico \nNúria Gavalda · Directora de Estrategia e Innovación del Banco de Sangre y Tejidos (BST)\n\n\n11:45\nTBC\nGiuseppe Battaglia · Institut de Bioenginyeria de Catalunya (IBEC)\n\n\n12:10\nApoyando la Investigación e Innovación en Cáncer\nSofía Cabezudo  · Gestora de Proyectos Asociación Española contra el Cáncer (AECC)\n\n\n12:30\nClausura\n\n\n\n  \nPara registrarse hacer click aquí.
URL:https://ibecbarcelona.eu/event/nano-cancer-day/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260216T113000
DTEND;TZID=Europe/Madrid:20260216T123000
DTSTAMP:20260404T001138
CREATED:20260128T102059Z
LAST-MODIFIED:20260128T102059Z
UID:131754-1771241400-1771245000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Monika E. Dolega
DESCRIPTION:Nucleolar mechano-adaptation and its role in epithelial homeostasis\nMonika E. Dolega\, Institute for Advanced Biosciences IAB\, INSERM U1209\, CNRS UMR5309\, University Grenoble-Alpes\, Grenoble\, France \n  \nEpithelial tissues experience constant mechanical stimuli tied to normal physiological functions\, but how they maintain homeostasis under such dynamic conditions remains unclear. Our previous RNAseq study on in-plane compressed epithelial monolayers revealed altered transcripts of ribosomal proteins essential for ribosome biogenesis in nucleoli—membrane-less\, sub-nuclear biocondensates that challenge classical mechanotransduction concepts. Although few studies confirm nucleolar sensitivity to external cues\, detailed mechanisms are lacking. Using advanced microscopy\, omics\, and biophysical approaches\, we uncover a new mechanism of nucleolar mechano-adaptation. Mechanical confinement over minutes reorganizes nucleolar structure and downregulates pre-rRNA transcription. Central to this process is the nucleolar protein Nucleolin\, which translocates to perform two roles: it leaves the rDNA promoter region to down-regulate ribosome biogenesis and participates in DNA repair at damage sites caused by compression. This study introduces the nucleolus as a mechano-sensitive organelle\, advancing mechanobiology and cancer research by revealing a new potential therapeutic target
URL:https://ibecbarcelona.eu/event/ibec-seminar-monika-e-dolega/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260217T090000
DTEND;TZID=Europe/Madrid:20260217T153000
DTSTAMP:20260404T001138
CREATED:20260122T111927Z
LAST-MODIFIED:20260122T111955Z
UID:131631-1771318800-1771342200@ibecbarcelona.eu
SUMMARY:Innovació científica i tecnològica en salut: transferència de resultats per a la medicina del futur
DESCRIPTION:i millorar la qualitat de vida de la ciutadana\, però sense transferència no hi ha impacte. Catalunya és un referent en recerca biomèdica i biotecnològica\, però el gran repte és transformar aquest coneixement en solucions reals que arribin a la clínica i al pacient. \nEn el marc de la Barcelona Health Innovation Week 2026\, des de l’Institut de Bioenginyeria de Catalunya (IBEC) organitzem aquesta jornada per demostrar que és possible connectar l’ecosistema de recerca amb el sistema de sanitari i empreses per impulsar la medicina personalitzada\, les teràpies avançades i les tecnologies que milloren el diagnòstic i el tractament. \nAquesta sessió posa el focus en la transferència tecnològica i en l’impacte real de la recerca. Presentarem els resultats del Pla Complementari de Biotecnologia aplicada a la salut a Catalunya\, un programa que ha fomentat la col·laboració entre centres de recerca i instituts sanitaris per desenvolupar solucions disruptives en salut. A més\, comptarem amb experts i expertes en transferència tecnològica\, inversió i gestió de la innovació que compartiran estratègies per accelerar la translació de coneixement cap al mercat i la clínica així com casos d’èxit que ja estan marcant el camí de la medicina del futur. \nSi vols conèixer de prop les claus de l’èxit en la translació de la medicina personalitzada\, connectar amb agents de l’ecosistema d’innovació i formar part de la conversa sobre el futur de la nostra salut\, no et perdis aquesta oportunitat única per entendre com la col·laboració i la inversió en innovació poden generar valor per a la societat. \nActivitat gratuïta. Registre obligatori aquí.
URL:https://ibecbarcelona.eu/event/innovacio-cientifica-i-tecnologica-en-salut-transferencia-de-resultats-per-a-la-medicina-del-futur/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External symposium / conference / congress,IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260227T090000
DTEND;TZID=Europe/Madrid:20260227T130000
DTSTAMP:20260404T001138
CREATED:20260128T091847Z
LAST-MODIFIED:20260204T141924Z
UID:131741-1772182800-1772197200@ibecbarcelona.eu
SUMMARY:Thematic Network. NET-CNS Workshop 3: Overcoming Therapeutic Barriers in CNS
DESCRIPTION:This third workshop will focus on overcoming therapeutic barriers in CNS disorders\, with particular emphasis on delivery strategies\, biological interfaces\, and translational challenges. \nSchedule \n09:00 – Registration\n09:20 – Welcome from Network Coordinator\n09:30 – IBEC speaker: Daniel Gonzalez-Carter\, Molecular Bionics group Group. “Exploiting the physiology of the BBB to target therapies to the brain.”Daniel Gonzalez-Carter\, IBEC Molecular Bionics Group\,\n10:00 – Invited speaker: Cristina Fornaguera\, NanoTherapies Lab\, Institut Químic de Sarrià (IQS)\, Universitat Ramon Llull (URL). “From Bench to Brain: Polymeric Nanoparticles for Controlled Brain Delivery”\n10:40 – Coffee Break and Networking\n11:10 – Invited speaker: Meritxell Teixidó\, Gate2Brain. “Gate2Brain blood-brain barrier shuttle peptides: From discovery to applications and going beyond small molecules”\n11:50 – Invited speaker: Eloi Montañez\, IDIBELL Department of Physiological Sciences .Faculty of Medicine and Health Sciences\, University of Barcelona. “Linking TDP-43 to Vascular Degeneration and Neuroinflammation”\n12:30 – IBEC speaker: Anna Lagunas\, IBEC Nanobioengineering Group\, “A BBB-on-a-chip (BBB-oC) with integrated micro-TEER to evaluate brain drug delivery”\n13:00 – End of the Workshop \nTo register\, click here.
URL:https://ibecbarcelona.eu/event/thematic-network-net-cns-workshop-3-overcoming-therapeutic-barriers-in-cns/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260305T100000
DTEND;TZID=Europe/Madrid:20260305T133000
DTSTAMP:20260404T001138
CREATED:20260122T112417Z
LAST-MODIFIED:20260122T112417Z
UID:131637-1772704800-1772717400@ibecbarcelona.eu
SUMMARY:Nano Rare Diseases Day
DESCRIPTION:El Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapias. \nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \n\n\n\n\n\n\nEs obligatorio registrarse aquí.
URL:https://ibecbarcelona.eu/event/nano-rare-diseases-day-3/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260311T080000
DTEND;TZID=Europe/Madrid:20260313T170000
DTSTAMP:20260404T001138
CREATED:20251022T124028Z
LAST-MODIFIED:20251022T124028Z
UID:129384-1773216000-1773421200@ibecbarcelona.eu
SUMMARY:4th edition EMBL-IBEC Conference Egineering Multicellular Systems
DESCRIPTION:EMBL and IBEC aim to contribute to the discussion on challenges and opportunities in the expanding field of engineered multicellular systems. \nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos. \nThis biennial series will focus on how engineering such systems is advancing our understanding of tissue and organ function\, with applications in disease modeling\, developmental biology\, and regenerative medicine. \nTo register click here
URL:https://ibecbarcelona.eu/event/4th-edition-embl-ibec-conference-egineering-multicellular-systems/
LOCATION:PRBB (Parc de Recerca Biomèdica de Barcelona)\, Ramon y Cajal Room
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260313T100000
DTEND;TZID=Europe/Madrid:20260313T110000
DTSTAMP:20260404T001138
CREATED:20260313T084522Z
LAST-MODIFIED:20260313T084522Z
UID:132678-1773396000-1773399600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Mykhailo Batiuk
DESCRIPTION:Glia\, Schizophrenia\, and Trauma at Cellular Resolution\n\nDr. Mykhailo Batiuk\,  École Polytechnique Fédérale de Lausanne.\n\nThe complexity of the brain in both health and pathology stems from its immense cellular heterogeneity. Consequently\, it is increasingly recognized that studying the brain at cellular resolution is essential for understanding its function. In this talk\, I will present my research focused on glial diversity and the molecular perturbations underlying psychiatric conditions\, investigated through the lens of single-cell genomics.\n\nFirst\, I will discuss the discovery of molecular and functional astrocyte heterogeneity. By leveraging single-cell RNA sequencing\, we revealed that astrocytes are not a uniform population but consist of distinct molecular subtypes with unique spatial locations and physiological properties. Second\, I will transition to human pathology\, where I utilized large-scale single-nucleus and spatial transcriptomics to map neuronal perturbations in schizophrenia. This work identified a “hotspot” of disturbance in the upper cortical layers\, providing a new map for understanding the cellular basis of the disorder. Finally\, I will present my current research on the epigenetic basis of traumatic memory. Together\, these insights provide a blueprint for my future research: identifying and validating novel genomic targets to alleviate the pathology of post-traumatic stress disorder (PTSD).
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-mykhailo-batiuk/
LOCATION:Baobab room\, Floor 11\, Tower 1
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260327T090000
DTEND;TZID=Europe/Madrid:20260327T133000
DTSTAMP:20260404T001138
CREATED:20260304T112012Z
LAST-MODIFIED:20260324T093807Z
UID:132411-1774602000-1774618200@ibecbarcelona.eu
SUMMARY:Thematic Network. NET-RARE Workshop 4: Bridging Rare Diseases Scientific Research and Clinical Needs
DESCRIPTION:This fourth workshop aims to bring together representatives from medical hospitals\, pharma and spin-off companies\, patient associations\, and research groups to create an interactive panel discussion on rare diseases from multiple perspectives. Following brief presentations introducing each participant’s research area and expertise\, a round-table discussion will take place after the coffee break to explore key challenges in communication and collaboration across disciplines. \nThe session will focus on how scientific research can more effectively address clinical needs\, and how clinicians can help guide and strengthen research directions. With contributions from patient associations and pharma/spin-off representatives\, the discussion will also highlight the development of effective therapies and the patient perspective\, emphasizing the importance of strong cross-sector collaboration in the rare disease landscape. \n  \nScheduled Program:  \n9.30-9.40: Welcome and short introduction of the workshop \n9.40-10.00: Invited speaker: Daniel Natera de Benito\, Neuromuscular Unit of Hospital Sant Joan de Déu (Barcelona) \n10.00-10.20: Invited speaker: Nora Ventosa\, Nora Ventosa\, Co-founder and CEO of DELBIOS Pharmaceuticals SL and Co-founder and President of Nanomol Technologies SL. \n10.20-10.40: Chiara Ninfali\, IBEC group “Biosensors for Bioengineering” \n10.40-11.00: Invited speaker: Maria Cols Roig\, from Pediatric Pulmonology Department and the Cystic Fibrosis Unit\, Sant Joan de Déu Hospital \n11.00-11.20: Invited speaker: Marisol Montolio dell’Olmo\, Scientific director of Duchenne Parent Project Spain Association \n11.20-12.00: Coffee Break and Networking \n12.00-13.00: Round Table \n13.00-13.10: Remarks and Closing \n  \nTo register click here
URL:https://ibecbarcelona.eu/event/thematic-network-net-rare-workshop-4-bridging-rare-diseases-scientific-research-and-clinical-needs/
LOCATION:Baobab room\, Floor 11\, Tower 1
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260408T150000
DTEND;TZID=Europe/Madrid:20260408T160000
DTSTAMP:20260404T001138
CREATED:20260331T123720Z
LAST-MODIFIED:20260331T123720Z
UID:133054-1775660400-1775664000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. M. Carolina Florian
DESCRIPTION:Targeting RhoA mechanoactivity rejuvenates aged hematopoietic stem cells  \nM. Carolina Florian\, Stem Cell Aging Group\, Regenerative Medicine Program\, The Bellvitge Institute for Biomedical Research (IDIBELL)\, L’Hospitalet de Llobregat\, Barcelona\, Spain. \nProgram for advancing the Clinical Translation of Regenerative Medicine of Catalonia\, P-CMR[C]\, Barcelona\, Spain\nThe Catalan Institution for Research and Advanced Studies (ICREA)\, Barcelona\, Spain\nMechanical alterations contribute to the decreased regenerative capacity of hematopoietic stem cells (HSCs) upon aging. RhoA is a key regulator of mechanosignaling\, but its role in mechanotransduction in stem cell aging remains unclear. Recently we have demonstrated that RhoA is activated by increasing nuclear envelope (NE) tension by cell confinement and by osmotic shock. Interestingly\, our data show that aged HSCs experience physiologically higher intrinsic NE tension and RhoA activation. We show that pharmacological inhibition of RhoA activity lowers NE tension in aged HSCs. Feature image analysis of HSC nuclei reveals that an aged dependent chromatin remodeling is responsible of higher NE tension levels upon aging. Moreover\, our data show that RhoA inhibition restores youthful levels of the heterochromatin marker H3K9me2 in aged HSCs and decreases chromatin accessibility and transcription at retrotransposons. Finally\, we demonstrated that RhoA inhibition in aged HSCs upregulates Klf4 expression and transcriptional activity\, improving aged HSC regenerative capacity and lympho-myeloid skewing in vivo. Together\, our data outline an intrinsic RhoA-dependent mechanosignaling axis in HSCs\, which can be pharmacologically targeted to restore aged stem cell function.
URL:https://ibecbarcelona.eu/event/ibec-seminar-m-carolina-florian/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260410T090000
DTEND;TZID=Europe/Madrid:20260410T160000
DTSTAMP:20260404T001138
CREATED:20260128T092058Z
LAST-MODIFIED:20260318T115649Z
UID:131745-1775811600-1775836800@ibecbarcelona.eu
SUMMARY:Thematic Network. NET-CNS Workshop 4: Innovations in CNS Modeling:Cutting-edge In Vitro Systems​
DESCRIPTION:Join us for the fourth NET-CNS Workshop on April 10th! \nThis fourth NET-CNS workshop will focus on innovative experimental platforms and technologies to model central nervous system (CNS) processes and diseases. Particular emphasis will be placed on advanced in vitro systems\, translational research tools\, and emerging technologies that enable more physiologically relevant models for studying CNS biology and developing therapeutic strategies. \nThe event will bring together experts from academia\, clinical research institutions\, and industry to discuss new approaches for understanding CNS function and pathology and for advancing biomedical innovation in neuroscience. \nSpeakers \n\nTeresa Botta Orfila – Head of the HCB-IDIBAPS Biobank (Barcelona). She leads initiatives in human biobanking\, biological sample management\, and translational infrastructures supporting biomedical research\, precision medicine\, and clinical studies.\nVíctor Borrell – Research Professor at the Instituto de Neurociencias (CSIC-UMH)\, Alicante. His research focuses on brain development and evolution\, particularly the cellular and molecular mechanisms that control neuronal migration\, cortical expansion\, and the formation of neural circuits.\nRosa Monge – Scientist at Beonchip (Zaragoza)\, a biotechnology company developing organ-on-chip technologies. Her work focuses on microphysiological systems and organ-on-chip platforms that enable the creation of advanced in vitro models for drug discovery and biomedical research.\nMaria Bernabeu – Group Leader at EMBL Barcelona. Her research integrates computational and experimental approaches to study tissue architecture and cellular organization\, using quantitative biology and advanced imaging to understand multicellular systems in health and disease.\nSandra Acosta – Professor at the University of Barcelona (UB) and researcher at Hospital Sant Joan de Déu and the Pasqual Maragall Foundation. Her research focuses on neurodegeneration and Alzheimer’s disease\, particularly on early pathological mechanisms\, neuroinflammation\, and translational strategies to identify biomarkers and therapeutic targets.\n\nProgramme \n09:30 – Registration \n09:50 – Welcome from Network Coordinator \n10:00 – IBEC Speaker: Jorge Oliver de la Cruz – Cellular and Molecular Mechanobiologygroup\, IBEC. “Mechanical cues regulate Tau axonal localization through microtubule stabilization” \n10:40 – Invited Speaker: Teresa Botta Orfila – Head of HCB-IDIBAPS Biobank\, Barcelona. “Biobanks as essential hubs for research”. \n11:20 – Coffee Break and Networking \n11:50 – Invited Speaker: Víctor Borrell – Instituto de Neurociencias (CSIC-UMH)\, Alicante. “Evolution of neural stem cells and lineages in the cerebral cortex of amniotes” \n12:30 – Industry Speaker: Rosa Monge – Beonchip\, Zaragoza. \n13:15 – Lunch Break \n14:15 – Invited Speaker: Maria Bernabeu – EMBL Barcelona. “Building and breaking barriers: bioengineered 3D brain microvascular models for malaria research” \n15:00 – Invited Speaker: Sandra Acosta – University of Barcelona\, Hospital Sant Joan de Déu & Pasqual Maragall Foundation\, Barcelona. “Modeling Neurological Disease Progression in vitro: The Promise and Pitfalls of Brain Organoids in Alzheimer’s and COVID-19” \n15:45 – End of the Workshop \nTo register click here.
URL:https://ibecbarcelona.eu/event/thematic-network-net-cns-workshop-4-innovations-in-cns-modelingcutting-edge-in-vitro-systems/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260415T120000
DTEND;TZID=Europe/Madrid:20260415T130000
DTSTAMP:20260404T001138
CREATED:20260320T075958Z
LAST-MODIFIED:20260320T080207Z
UID:132904-1776254400-1776258000@ibecbarcelona.eu
SUMMARY:Ibec Seminar: Dr. Federico Fenaroli
DESCRIPTION:Developing Nanomedicines Using the Zebrafish Embryo\nDr. Federico Fenaroli\,  University of Stavanger\, Norwey \nOur research focuses on the development of nanomedicines to combat bacterial infections and cancer. We investigate the dynamic in vivo interactions between nanoparticles\, immune cells\, and pathogenic bacteria or cancer cells. Thanks to their natural transparency\, zebrafish embryos enable high-resolution imaging and real-time tracking of nanoparticles within a living organism. This model provides valuable insights into therapeutic behavior\, biodistribution\, and host–pathogen interactions\, supporting the rational design of nanomedicines.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-federico-fenaroli/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260417T110000
DTEND;TZID=Europe/Madrid:20260417T110000
DTSTAMP:20260404T001138
CREATED:20250915T091947Z
LAST-MODIFIED:20250915T124500Z
UID:128356-1776423600-1776423600@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Prof. Kara Spiller
DESCRIPTION:Engineering Macrophages with Biomaterials for Regenerative Medicine\nKara L. Spiller\, PhD\, URBN Professor of Biomedical Innovation\, School of Biomedical Engineering\, Science\, and Health Systems\, Drexel University\, Philadelphia\, PA\, USA \nThe inflammatory response\, orchestrated primarily by macrophages\, plays a major role in the body’s response to injury\, disease\, or implantation of a biomaterial. When macrophages function normally\, they are a powerful force that promote tissue repair and regeneration\, but when their behavior goes awry\, healing is impaired. Our goal is to understand the mechanisms by which the inflammatory response orchestrates successful tissue regeneration and to develop novel biomaterial strategies that apply these principles to situations in which tissue regeneration is impaired. In particular\, we study macrophages in inflammation\, phagocytosis\, cellular recruitment\, vascularization\, cell proliferation\, tissue deposition\, or remodeling\, and we design biomaterials that leverage these findings for improved biomaterials design\, enhanced macrophage cell therapy\, and personalized medicine. Current projects in the lab are directed towards treatment of pulmonary fibrosis and chronic wound healing through biomaterial-enabled macrophage cell therapies. \nDr. Kara Spiller is the URBN Endowed Professor of Biomedical Innovation in Drexel University’s School of Biomedical Engineering\, Science\, and Health Systems. Her research focuses on the role of immune cells in tissue repair and regeneration and the design of immunomodulatory biomaterials. Her research is funded by the NIH\, the NSF\, private foundations\, and industry. Her awards include a Fulbright fellowship\, the NSF CAREER award\, and the United States Dept. of State ASPIRE prize. She has published more than 85 publications in biomaterials and immune engineering\, and has 18 issued or pending patents. She is the founding director of the Immune Modulation & Engineering Symposium series in Philadelphia\, which is the only annually recurring meeting dedicated to convergent research in translational immunology and engineering. She serves on the board of numerous journals and is a frequent NIH study section member.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-kara-spiller/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260430T104500
DTEND;TZID=Europe/Madrid:20260430T130000
DTSTAMP:20260404T001138
CREATED:20260320T095836Z
LAST-MODIFIED:20260320T095836Z
UID:132910-1777545900-1777554000@ibecbarcelona.eu
SUMMARY:Research4talent
DESCRIPTION:The event offers you the opportunity to engage with our researchers and inquire about their day-to-day work in the lab\, career trajectories\, work-life balance\, mobility\, etc. \nIn 2025\, IBEC signed more than 140 internship agreements for undergraduate and master’s students with a wide range of national and international universities. \n\n\nPROGRAMME · 30th April 2026 \n\n\n\n\n\n\n\n10:45\nWelcome\n\n\n11:00\nDeputy talent and training director talk. Elisabeth Engel\, “What is IBEC?”\n\n\n11:20\nPeople Management Speech\n\n\n11:30\nPhD Committee presentation\n\n\n\n-Coffee break-\n\n\n11:45\nCareers Fair*: a chance for participants to mingle and chat with our researchers.\n\n\n13:00\nLabs visits\n\n\n\n\n\nIf you are interested in IBEC’s twelfth edition of reSEARCH4TALENT\, please register.
URL:https://ibecbarcelona.eu/event/research4talent-8/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260513T140000
DTEND;TZID=Europe/Madrid:20260513T150000
DTSTAMP:20260404T001138
CREATED:20260320T101141Z
LAST-MODIFIED:20260320T101141Z
UID:132912-1778680800-1778684400@ibecbarcelona.eu
SUMMARY:Ibec Seminar:  Dr Pascale Quilichini
DESCRIPTION:Neuronal infra-slow rhythm in the thalamic nucleus reuniens orchestrate hippocampo-prefrontal information flow during sleep\nDr Pascale Quilichini\, Institut de Neurosciences des Systèmes\, INSERM\, Aix-Marseille University \nThe consolidation of episodic memory during sleep relies on coordinated interactions between the hippocampus (HPC) and the prefrontal cortex (PFC)\, although these regions lack direct reciprocal connections. The thalamic nucleus reuniens (NR)\, which is bidirectionally connected to both structures\, is therefore a strong candidate for mediating this dialogue. Using simultaneous silicon-probes recordings from the HPC\, NR\, and PFC in freely sleeping rats\, we identified a previously undescribed infra-slow rhythm (ISR) in NR neuronal activity predominantly during non-rapid eye movement (NREM) sleep.\nHPC and PFC neurons were differentially entrained to distinct phases of this rhythm. Consistently\, hippocampal sharp-wave ripples (SWRs) and prefrontal spindles occurred also preferentially during slightly different ISR phases. Coupled SWR–spindle events peaked at the onset of the ON phase.\nFurthermore\, this coupling was stronger during NREM epochs dominated by ISR compared to those without ISR\, and\, most importantly\, was significantly enhanced during ISR-dominated NREM sleep following spatial learning.\nTogether\, these findings reveal a novel infra-slow population dynamic in the NR that may temporally coordinate hippocampo–prefrontal interactions during sleep\, positioning this nucleus as a key hub in this network supporting memory consolidation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-pascale-quilichini/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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