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DTSTART:20170326T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181114T120000
DTEND;TZID=Europe/Madrid:20181114T140000
DTSTAMP:20260403T200516
CREATED:20181029T094546Z
LAST-MODIFIED:20181029T094546Z
UID:96332-1542196800-1542204000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Joan Martí Muñoz
DESCRIPTION:Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration\nJoan Martí Muñoz\, Biomaterials for Regenerative Therapies group\nJoan will be defending his PhD thesis on Wednesday 14th November at 12:00 in the Sala d’Actes of the UPC’s Facultat de Matemàtiques i Estadística\, Campus Diagonal Sud\, Carrer de Pau Gargallo. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-joan-marti-munoz-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181114T120000
DTEND;TZID=Europe/Madrid:20181114T140000
DTSTAMP:20260403T200516
CREATED:20181029T094546Z
LAST-MODIFIED:20181029T094546Z
UID:96335-1542196800-1542204000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Joan Martí Muñoz
DESCRIPTION:Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration\nJoan Martí Muñoz\, Biomaterials for Regenerative Therapies group\nJoan will be defending his PhD thesis on Wednesday 14th November at 12:00 in the Sala d’Actes of the UPC’s Facultat de Matemàtiques i Estadística\, Campus Diagonal Sud\, Carrer de Pau Gargallo. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-joan-marti-munoz-3/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181114T120000
DTEND;TZID=Europe/Madrid:20181114T140000
DTSTAMP:20260403T200516
CREATED:20181029T094546Z
LAST-MODIFIED:20181030T095833Z
UID:62278-1542196800-1542204000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Joan Martí Muñoz
DESCRIPTION:Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration\nJoan Martí Muñoz\, Biomaterials for Regenerative Therapies group\nJoan will be defending his PhD thesis on Wednesday 14th November at 12:00 in the Sala d’Actes of the UPC’s Facultat de Matemàtiques i Estadística\, Campus Diagonal Sud\, Carrer de Pau Gargallo. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-joan-marti-munoz/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181114T120000
DTEND;TZID=Europe/Madrid:20181114T140000
DTSTAMP:20260403T200516
CREATED:20181029T094546Z
LAST-MODIFIED:20181029T094546Z
UID:96336-1542196800-1542204000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Joan Martí Muñoz
DESCRIPTION:Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration\nJoan Martí Muñoz\, Biomaterials for Regenerative Therapies group\nJoan will be defending his PhD thesis on Wednesday 14th November at 12:00 in the Sala d’Actes of the UPC’s Facultat de Matemàtiques i Estadística\, Campus Diagonal Sud\, Carrer de Pau Gargallo. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-joan-marti-munoz-4/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181109T120000
DTEND;TZID=Europe/Madrid:20181109T140000
DTSTAMP:20260403T200516
CREATED:20181105T125017Z
LAST-MODIFIED:20181105T125017Z
UID:96343-1541764800-1541772000@ibecbarcelona.eu
SUMMARY:Workshop organized with Mind the Byte
DESCRIPTION:Computational chemistry in drug discovery: the SME perspective\nBusiness Development Director Mariona Esquerdo and Product Manager Fernando Martín\, Mind the Byte\nMind the Byte is a bioinformatics company specializing in the development of new technologies applied to drug discovery. As a SME (small/medium-sized enterprise) we focus our resources in the research and development of new technologies\, applying cutting-edge methods in artificial intelligence and cloud computing\, providing to our clients with the best resources for the success of their projects. In this workshop we will present the company\, how computational chemistry can help the drug discovery process and how we have made accessible our technology through our platform. \nThey have been invited by Giulia Fornabaio of IBEC’s PhD Committee\, which will provide a pica-pica after the event.
URL:https://ibecbarcelona.eu/event/workshop-organized-with-mind-the-byte-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181109T120000
DTEND;TZID=Europe/Madrid:20181109T140000
DTSTAMP:20260403T200516
CREATED:20181105T125017Z
LAST-MODIFIED:20181105T125017Z
UID:96342-1541764800-1541772000@ibecbarcelona.eu
SUMMARY:Workshop organized with Mind the Byte
DESCRIPTION:Computational chemistry in drug discovery: the SME perspective\nBusiness Development Director Mariona Esquerdo and Product Manager Fernando Martín\, Mind the Byte\nMind the Byte is a bioinformatics company specializing in the development of new technologies applied to drug discovery. As a SME (small/medium-sized enterprise) we focus our resources in the research and development of new technologies\, applying cutting-edge methods in artificial intelligence and cloud computing\, providing to our clients with the best resources for the success of their projects. In this workshop we will present the company\, how computational chemistry can help the drug discovery process and how we have made accessible our technology through our platform. \nThey have been invited by Giulia Fornabaio of IBEC’s PhD Committee\, which will provide a pica-pica after the event.
URL:https://ibecbarcelona.eu/event/workshop-organized-with-mind-the-byte-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181109T120000
DTEND;TZID=Europe/Madrid:20181109T140000
DTSTAMP:20260403T200517
CREATED:20181105T125017Z
LAST-MODIFIED:20181105T125017Z
UID:62407-1541764800-1541772000@ibecbarcelona.eu
SUMMARY:Workshop organized with Mind the Byte
DESCRIPTION:Computational chemistry in drug discovery: the SME perspective\nBusiness Development Director Mariona Esquerdo and Product Manager Fernando Martín\, Mind the Byte\nMind the Byte is a bioinformatics company specializing in the development of new technologies applied to drug discovery. As a SME (small/medium-sized enterprise) we focus our resources in the research and development of new technologies\, applying cutting-edge methods in artificial intelligence and cloud computing\, providing to our clients with the best resources for the success of their projects. In this workshop we will present the company\, how computational chemistry can help the drug discovery process and how we have made accessible our technology through our platform. \nThey have been invited by Giulia Fornabaio of IBEC’s PhD Committee\, which will provide a pica-pica after the event.
URL:https://ibecbarcelona.eu/event/workshop-organized-with-mind-the-byte/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181109T120000
DTEND;TZID=Europe/Madrid:20181109T140000
DTSTAMP:20260403T200517
CREATED:20181105T125017Z
LAST-MODIFIED:20181105T125017Z
UID:96341-1541764800-1541772000@ibecbarcelona.eu
SUMMARY:Workshop organized with Mind the Byte
DESCRIPTION:Computational chemistry in drug discovery: the SME perspective\nBusiness Development Director Mariona Esquerdo and Product Manager Fernando Martín\, Mind the Byte\nMind the Byte is a bioinformatics company specializing in the development of new technologies applied to drug discovery. As a SME (small/medium-sized enterprise) we focus our resources in the research and development of new technologies\, applying cutting-edge methods in artificial intelligence and cloud computing\, providing to our clients with the best resources for the success of their projects. In this workshop we will present the company\, how computational chemistry can help the drug discovery process and how we have made accessible our technology through our platform. \nThey have been invited by Giulia Fornabaio of IBEC’s PhD Committee\, which will provide a pica-pica after the event.
URL:https://ibecbarcelona.eu/event/workshop-organized-with-mind-the-byte-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181109T100000
DTEND;TZID=Europe/Madrid:20181109T110000
DTSTAMP:20260403T200517
CREATED:20181004T075934Z
LAST-MODIFIED:20181004T075934Z
UID:96321-1541757600-1541761200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: new junior group leader Benedetta Bolognesi
DESCRIPTION:Title TBC\nBenedetta Bolognesi\, IBEC\nComing soon \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-junior-group-leader-benedetta-bolognesi-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181109T100000
DTEND;TZID=Europe/Madrid:20181109T110000
DTSTAMP:20260403T200517
CREATED:20181004T075934Z
LAST-MODIFIED:20181004T075934Z
UID:96322-1541757600-1541761200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: new junior group leader Benedetta Bolognesi
DESCRIPTION:Title TBC\nBenedetta Bolognesi\, IBEC\nComing soon \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-junior-group-leader-benedetta-bolognesi-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181108T170000
DTEND;TZID=Europe/Madrid:20181108T190000
DTSTAMP:20260403T200517
CREATED:20181105T085615Z
LAST-MODIFIED:20181105T085615Z
UID:96338-1541696400-1541703600@ibecbarcelona.eu
SUMMARY:I'll Push You
DESCRIPTION:Take a break to enjoy a movie and help accelerate research into muscular dystrophy!\nIBEC\, in collaboration with the PCB\, is organizing a special screening of \n“I’ll Push You”\nThis inspiring feature-length documentary follows Justin Skeesuck and Patrick Gray\, the first people to complete the Camino de Santiago in a wheelchair. \nEntrance is free\, although donations to the Faster Future campaign will be gladly accepted! Feel free to invite your friends and family. \nThursday 8th November\, 5:00 pm · Auditorium Antoni Caparrós\, PCB\nIn English with Spanish subtitles\nRegister here: https://i-ll-push-you.eventbrite.com
URL:https://ibecbarcelona.eu/event/ill-push-you-2-2/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181108T170000
DTEND;TZID=Europe/Madrid:20181108T190000
DTSTAMP:20260403T200517
CREATED:20181105T085615Z
LAST-MODIFIED:20181105T085615Z
UID:96339-1541696400-1541703600@ibecbarcelona.eu
SUMMARY:I'll Push You
DESCRIPTION:Take a break to enjoy a movie and help accelerate research into muscular dystrophy!\nIBEC\, in collaboration with the PCB\, is organizing a special screening of \n“I’ll Push You”\nThis inspiring feature-length documentary follows Justin Skeesuck and Patrick Gray\, the first people to complete the Camino de Santiago in a wheelchair. \nEntrance is free\, although donations to the Faster Future campaign will be gladly accepted! Feel free to invite your friends and family. \nThursday 8th November\, 5:00 pm · Auditorium Antoni Caparrós\, PCB\nIn English with Spanish subtitles\nRegister here: https://i-ll-push-you.eventbrite.com
URL:https://ibecbarcelona.eu/event/ill-push-you-2-3/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181108T170000
DTEND;TZID=Europe/Madrid:20181108T190000
DTSTAMP:20260403T200517
CREATED:20181105T085615Z
LAST-MODIFIED:20181105T085615Z
UID:96340-1541696400-1541703600@ibecbarcelona.eu
SUMMARY:I'll Push You
DESCRIPTION:Take a break to enjoy a movie and help accelerate research into muscular dystrophy!\nIBEC\, in collaboration with the PCB\, is organizing a special screening of \n“I’ll Push You”\nThis inspiring feature-length documentary follows Justin Skeesuck and Patrick Gray\, the first people to complete the Camino de Santiago in a wheelchair. \nEntrance is free\, although donations to the Faster Future campaign will be gladly accepted! Feel free to invite your friends and family. \nThursday 8th November\, 5:00 pm · Auditorium Antoni Caparrós\, PCB\nIn English with Spanish subtitles\nRegister here: https://i-ll-push-you.eventbrite.com
URL:https://ibecbarcelona.eu/event/ill-push-you-2-4/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181108T170000
DTEND;TZID=Europe/Madrid:20181108T190000
DTSTAMP:20260403T200517
CREATED:20181105T085615Z
LAST-MODIFIED:20181105T085956Z
UID:62365-1541696400-1541703600@ibecbarcelona.eu
SUMMARY:I'll Push You
DESCRIPTION:Take a break to enjoy a movie and help accelerate research into muscular dystrophy!\nIBEC\, in collaboration with the PCB\, is organizing a special screening of \n“I’ll Push You”\nThis inspiring feature-length documentary follows Justin Skeesuck and Patrick Gray\, the first people to complete the Camino de Santiago in a wheelchair. \nEntrance is free\, although donations to the Faster Future campaign will be gladly accepted! Feel free to invite your friends and family. \nThursday 8th November\, 5:00 pm · Auditorium Antoni Caparrós\, PCB\nIn English with Spanish subtitles\nRegister here: https://i-ll-push-you.eventbrite.com
URL:https://ibecbarcelona.eu/event/ill-push-you-2/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181101T080000
DTEND;TZID=Europe/Madrid:20181102T170000
DTSTAMP:20260403T200517
CREATED:20180412T102052Z
LAST-MODIFIED:20180412T102052Z
UID:96235-1541059200-1541178000@ibecbarcelona.eu
SUMMARY:II International Symposium on Photopharmacology (ISPP2018)
DESCRIPTION:Innovative therapeutics using light\nPhotopharmacology is an emerging branch of science based in the administration of a photosensitive compound in combination with illumination to provide a high degree of local and temporal control of compound activity\, which makes it useful both for therapeutic applications and as a research tool. \nIn the last 10 years photopharmacology\, a polyhedric science involving biology\, pharmacology\, chemistry\, physics\, engineering and medicine\, has flourished and achieved a critical mass of researchers and resourceful methods in chemistry and optics\, raising hopes for clinical trials of the most advanced compounds. \nThe First International Symposium on Photopharmacology took place at the University Medical Center Groningen on February 16th\, 2017. Topics covered in this First Symposium ranged from photochemistry and organic synthesis to vision restoration and brain research. \nInformation: http://events.ibecbarcelona.eu/ispp2018/
URL:https://ibecbarcelona.eu/event/ii-international-symposium-on-photopharmacology-ispp2018-4/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181101T080000
DTEND;TZID=Europe/Madrid:20181102T170000
DTSTAMP:20260403T200517
CREATED:20180412T102052Z
LAST-MODIFIED:20180412T102052Z
UID:96234-1541059200-1541178000@ibecbarcelona.eu
SUMMARY:II International Symposium on Photopharmacology (ISPP2018)
DESCRIPTION:Innovative therapeutics using light\nPhotopharmacology is an emerging branch of science based in the administration of a photosensitive compound in combination with illumination to provide a high degree of local and temporal control of compound activity\, which makes it useful both for therapeutic applications and as a research tool. \nIn the last 10 years photopharmacology\, a polyhedric science involving biology\, pharmacology\, chemistry\, physics\, engineering and medicine\, has flourished and achieved a critical mass of researchers and resourceful methods in chemistry and optics\, raising hopes for clinical trials of the most advanced compounds. \nThe First International Symposium on Photopharmacology took place at the University Medical Center Groningen on February 16th\, 2017. Topics covered in this First Symposium ranged from photochemistry and organic synthesis to vision restoration and brain research. \nInformation: http://events.ibecbarcelona.eu/ispp2018/
URL:https://ibecbarcelona.eu/event/ii-international-symposium-on-photopharmacology-ispp2018-3/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181101T080000
DTEND;TZID=Europe/Madrid:20181102T170000
DTSTAMP:20260403T200517
CREATED:20180412T102052Z
LAST-MODIFIED:20181025T121727Z
UID:58375-1541059200-1541178000@ibecbarcelona.eu
SUMMARY:II International Symposium on Photopharmacology (ISPP2018)
DESCRIPTION:II International Symposium on Photopharmacology (ISPP2018) – Innovative therapeutics using light\nThe world’s leading researchers and experts in the field will meet at the second international photopharmacology symposium in Vic on 1 and 2 November. \nThe convention is being organised jointly by the University of Vic – Central University of Catalonia (UVic-UCC)\, the Bioengineering Institute of Catalonia (IBEC) and the Institute for Advanced Chemistry of Catalonia – Spanish National Research Council (IQAC-CSIC). More than 120 people\, the vast majority of whom come from countries other than Spain\, will be attending the event\, which will take place in the Torre dels Frares building at the UVic. \nThe symposium will include around twenty lectures\, three blocks of short presentations and two poster sessions. The speakers include Ben Feringa\, of the University of Groningen (Netherlands)\, who was awarded the Nobel Prize in Chemistry in 2016 for the design and synthesis of molecular machines – an award he shared with Jean-Pierre Sauvage and Fraser Stoddart. Among others\, the scheduled lectures include those by Edith C. Glazer of the University of Kentucky\, who is working on the development of complex metals such as possible photoactive drugs\, and by Austria’s Dirk Trauner of the University of New York\, focusing on the application of photopharmacology in neurobiology. One of the main achievements of his team\, working with Richard Kramer and Ehud Isacoff\, has been to restore sight in blind animals\, using drugs that respond to visible light as molecular prostheses. \nInformation: http://events.ibecbarcelona.eu/ispp2018/ \n  \nWhat is photopharmacology? \nPhotopharmacology is based on administering photosensitive compounds as drugs\, which are only activated and take effect in combination with light. This specific characteristic provides a high level of control over the administration of medications and therapies\, since it means that the specific point of the body where it is applied and the duration of the application can be decided. This precision and location means that as a technique\, photopharmacological treatments are not invasive\, and can achieve optimum results with minimal secondary effects. \nAlthough its history dates back to the 1960s\, photopharmacology has primarily developed over the last ten years. During this period\, a significant critical mass of researchers has been created in research centres and universities around the world that focus on the field from various perspectives. It is a multifaceted science\, which includes biology\, pharmacology\, physics\, chemistry\, engineering and medicine. Its applications are also extremely wide-ranging: it may be therapeutically useful in a wide variety of medical fields\, within which neurosciences and cardiology are particularly important. Some applications that are being studied could also provide substantial improvements in pathologies such as diabetes and chronic pain. Photopharmacology can also be used as a research tool\, and can be combined with other technologies\, such as materials nanotechnology. \n 
URL:https://ibecbarcelona.eu/event/ii-international-symposium-on-photopharmacology-ispp2018/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181101T080000
DTEND;TZID=Europe/Madrid:20181102T170000
DTSTAMP:20260403T200517
CREATED:20180412T102052Z
LAST-MODIFIED:20180412T102052Z
UID:96225-1541059200-1541178000@ibecbarcelona.eu
SUMMARY:II International Symposium on Photopharmacology (ISPP2018)
DESCRIPTION:II International Symposium on Photopharmacology (ISPP2018) – Innovative therapeutics using light\nThe world’s leading researchers and experts in the field will meet at the second international photopharmacology symposium in Vic on 1 and 2 November. \nThe convention is being organised jointly by the University of Vic – Central University of Catalonia (UVic-UCC)\, the Bioengineering Institute of Catalonia (IBEC) and the Institute for Advanced Chemistry of Catalonia – Spanish National Research Council (IQAC-CSIC). More than 120 people\, the vast majority of whom come from countries other than Spain\, will be attending the event\, which will take place in the Torre dels Frares building at the UVic. \nThe symposium will include around twenty lectures\, three blocks of short presentations and two poster sessions. The speakers include Ben Feringa\, of the University of Groningen (Netherlands)\, who was awarded the Nobel Prize in Chemistry in 2016 for the design and synthesis of molecular machines – an award he shared with Jean-Pierre Sauvage and Fraser Stoddart. Among others\, the scheduled lectures include those by Edith C. Glazer of the University of Kentucky\, who is working on the development of complex metals such as possible photoactive drugs\, and by Austria’s Dirk Trauner of the University of New York\, focusing on the application of photopharmacology in neurobiology. One of the main achievements of his team\, working with Richard Kramer and Ehud Isacoff\, has been to restore sight in blind animals\, using drugs that respond to visible light as molecular prostheses. \nInformation: http://events.ibecbarcelona.eu/ispp2018/ \n  \nWhat is photopharmacology? \nPhotopharmacology is based on administering photosensitive compounds as drugs\, which are only activated and take effect in combination with light. This specific characteristic provides a high level of control over the administration of medications and therapies\, since it means that the specific point of the body where it is applied and the duration of the application can be decided. This precision and location means that as a technique\, photopharmacological treatments are not invasive\, and can achieve optimum results with minimal secondary effects. \nAlthough its history dates back to the 1960s\, photopharmacology has primarily developed over the last ten years. During this period\, a significant critical mass of researchers has been created in research centres and universities around the world that focus on the field from various perspectives. It is a multifaceted science\, which includes biology\, pharmacology\, physics\, chemistry\, engineering and medicine. Its applications are also extremely wide-ranging: it may be therapeutically useful in a wide variety of medical fields\, within which neurosciences and cardiology are particularly important. Some applications that are being studied could also provide substantial improvements in pathologies such as diabetes and chronic pain. Photopharmacology can also be used as a research tool\, and can be combined with other technologies\, such as materials nanotechnology. \n 
URL:https://ibecbarcelona.eu/event/ii-international-symposium-on-photopharmacology-ispp2018-2/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181030T093000
DTEND;TZID=Europe/Madrid:20181030T103000
DTSTAMP:20260403T200517
CREATED:20181024T081903Z
LAST-MODIFIED:20181024T081903Z
UID:62210-1540891800-1540895400@ibecbarcelona.eu
SUMMARY:IBEC-IRB Barcelona joint seminar: Guillaume Salbreux\, Francis Crick Institute
DESCRIPTION:Physics of epithelial flows and folds\nGuillaume Salbreux\, Theoretical Physics of Biology Laboratory\, The Francis Crick Institute\, London\nThe shape of a biological tissue is determined by mechanical stresses acting within the tissue cells. During embryonic morphogenesis\, forces generated in the actomyosin cytoskeleton in the cell of epithelia result in cell deformation\, cell rearrangements\, and 3D bending of the epithelium. To understand tissue morphogenesis\, force generation at the cellular scale must be related to flows and deformation occurring at the tissue scale. Here I will discuss how this relation can be captured by a 3D vertex model or by a continuum theory of active surfaces to understand epithelial fold formation during embryonic development. Using this framework\, one finds that two different mechanisms\, basal relaxation and lateral constriction\, can account for fold formation in the Drosophila wing disc. I will also discuss how planar tissue flows are related to cell shape changes and cell division\, and show how the growth of the Drosophila histoblast nests can be decomposed into basic cellular events.
URL:https://ibecbarcelona.eu/event/ibec-irb-barcelona-joint-seminar-guillaume-salbreux-francis-crick-institute/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181030T093000
DTEND;TZID=Europe/Madrid:20181030T103000
DTSTAMP:20260403T200517
CREATED:20181024T081903Z
LAST-MODIFIED:20181024T081903Z
UID:96327-1540891800-1540895400@ibecbarcelona.eu
SUMMARY:IBEC-IRB Barcelona joint seminar: Guillaume Salbreux\, Francis Crick Institute
DESCRIPTION:Physics of epithelial flows and folds\nGuillaume Salbreux\, Theoretical Physics of Biology Laboratory\, The Francis Crick Institute\, London\nThe shape of a biological tissue is determined by mechanical stresses acting within the tissue cells. During embryonic morphogenesis\, forces generated in the actomyosin cytoskeleton in the cell of epithelia result in cell deformation\, cell rearrangements\, and 3D bending of the epithelium. To understand tissue morphogenesis\, force generation at the cellular scale must be related to flows and deformation occurring at the tissue scale. Here I will discuss how this relation can be captured by a 3D vertex model or by a continuum theory of active surfaces to understand epithelial fold formation during embryonic development. Using this framework\, one finds that two different mechanisms\, basal relaxation and lateral constriction\, can account for fold formation in the Drosophila wing disc. I will also discuss how planar tissue flows are related to cell shape changes and cell division\, and show how the growth of the Drosophila histoblast nests can be decomposed into basic cellular events.
URL:https://ibecbarcelona.eu/event/ibec-irb-barcelona-joint-seminar-guillaume-salbreux-francis-crick-institute-4/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181030T093000
DTEND;TZID=Europe/Madrid:20181030T103000
DTSTAMP:20260403T200517
CREATED:20181024T081903Z
LAST-MODIFIED:20181024T081903Z
UID:96325-1540891800-1540895400@ibecbarcelona.eu
SUMMARY:IBEC-IRB Barcelona joint seminar: Guillaume Salbreux\, Francis Crick Institute
DESCRIPTION:Physics of epithelial flows and folds\nGuillaume Salbreux\, Theoretical Physics of Biology Laboratory\, The Francis Crick Institute\, London\nThe shape of a biological tissue is determined by mechanical stresses acting within the tissue cells. During embryonic morphogenesis\, forces generated in the actomyosin cytoskeleton in the cell of epithelia result in cell deformation\, cell rearrangements\, and 3D bending of the epithelium. To understand tissue morphogenesis\, force generation at the cellular scale must be related to flows and deformation occurring at the tissue scale. Here I will discuss how this relation can be captured by a 3D vertex model or by a continuum theory of active surfaces to understand epithelial fold formation during embryonic development. Using this framework\, one finds that two different mechanisms\, basal relaxation and lateral constriction\, can account for fold formation in the Drosophila wing disc. I will also discuss how planar tissue flows are related to cell shape changes and cell division\, and show how the growth of the Drosophila histoblast nests can be decomposed into basic cellular events.
URL:https://ibecbarcelona.eu/event/ibec-irb-barcelona-joint-seminar-guillaume-salbreux-francis-crick-institute-2/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181030T093000
DTEND;TZID=Europe/Madrid:20181030T103000
DTSTAMP:20260403T200517
CREATED:20181024T081903Z
LAST-MODIFIED:20181024T081903Z
UID:96326-1540891800-1540895400@ibecbarcelona.eu
SUMMARY:IBEC-IRB Barcelona joint seminar: Guillaume Salbreux\, Francis Crick Institute
DESCRIPTION:Physics of epithelial flows and folds\nGuillaume Salbreux\, Theoretical Physics of Biology Laboratory\, The Francis Crick Institute\, London\nThe shape of a biological tissue is determined by mechanical stresses acting within the tissue cells. During embryonic morphogenesis\, forces generated in the actomyosin cytoskeleton in the cell of epithelia result in cell deformation\, cell rearrangements\, and 3D bending of the epithelium. To understand tissue morphogenesis\, force generation at the cellular scale must be related to flows and deformation occurring at the tissue scale. Here I will discuss how this relation can be captured by a 3D vertex model or by a continuum theory of active surfaces to understand epithelial fold formation during embryonic development. Using this framework\, one finds that two different mechanisms\, basal relaxation and lateral constriction\, can account for fold formation in the Drosophila wing disc. I will also discuss how planar tissue flows are related to cell shape changes and cell division\, and show how the growth of the Drosophila histoblast nests can be decomposed into basic cellular events.
URL:https://ibecbarcelona.eu/event/ibec-irb-barcelona-joint-seminar-guillaume-salbreux-francis-crick-institute-3/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181026T100000
DTEND;TZID=Europe/Madrid:20181026T110000
DTSTAMP:20260403T200517
CREATED:20181019T082001Z
LAST-MODIFIED:20181019T082223Z
UID:62113-1540548000-1540551600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Anna Vila and Alexandre Gomila
DESCRIPTION:Engineering of 3D Small Intestinal Mucosa Models\nAnna Vila\, Biomimetic Systems for Cell Engineering\nHydrogels have been used as a scaffold for engineering tissue-like structures due to their biocompatibility and properties similar to the extracellular matrix. There are two main types of hydrogels (i) natural hydrogels\, such as gelatin\, which are biodegradable and present cell adhesion motifs and (ii) synthetic hydrogels\, such as poly(ethylene glycol) diacrylate (PEGDA)\, which are non-biodegradable and can withstand long-term cell cultures but do not have bioadhesion sequences [El-Sherbiny M.I. et al.\, 2013]. Both types of hydrogels present complementary benefits. \nFor this reason\, we fabricated a hydrogel co-polymer composed of gelatin methacrylate (GelMA) co-polymerized with PEGDA [Hutson. B.C. et al.\, 2011]. We employed a single-step\, moldless\, UV-photolithography-based fabrication technique [Castaño A. et al.\, submitted] to fabricate scaffolds mimicking the 3D architecture of the small intestinal mucosa. Using this approach\, we obtained hydrogel co-polymers with finger-like microstructures\, with the roundness and dimensions found in the villi of the native tissue. Mechanical and physicochemical properties such as an approach of the Young’s modulus\, degradation rate and swelling ratio of the hydrogels have been characterized. Adding PEGDA to the GelMA hydrogels have provided hydrogels with lower degradation and higher Young’s modulus\, which ca be easily tuned by changing the composition of GelMA and PEGDA polymers. Furthermore\, we have demonstrated that our scaffolds support the growth and differentiation of intestinal epithelial Caco-2 cells up to 21 days\, obtaining a matured epithelial monolayer with effective tissue barrier properties. \nAdditionally\, we increased the complexity of our model of the small intestinal mucosa by incorporating an additional cell compartment to mimic the stroma of the in vivo tissue. To do that\, we embedded 3T3-NIH fibroblasts in our scaffolds during the photopolymerization procedure. Then\, we cultured Caco-2 cells on top of the 3T3-NIH fibroblast-laden hydrogels up to 21 days. Our preliminary results showed that the co-culture of Caco-2 cells with 3T3-NIH fibroblasts favours the epithelial cell growth and improves their barrier function. Taking all together\, we have generated an intestinal mucosa model that allows for the co-culture of different intestinal cell types distributed in compartments\, mimicking the spatial-physiological features of the small intestinal mucosa. We believe our model better recapitulates cell-cell crosstalk and cell-matrix interactions found in vivo\, being an improved alternative for the cell-base in vitro assays. \n  \nIn vivo photomodulation of GABA and Glycine receptor channels\nAlexandre Gomila\, Nanoprobes and Nanoswitches\nNeuronal networks are highly complex interactions\, which determine even the finest behaviour. The major inhibitory pathways in the central nervous system (CNS) act through chloride ion flux\, which are mostly driven by fast-acting ionotropic GABAA and Glycine receptors (GlyR). All of them share structural similarities and belong to pentameric ligand-gated ion channels of the Cys-loop family. Photoswitchable molecules have become a powerful tool in any applied field of bioscience\, and are broadly used in biomedical research due to their capacity for enlightening biological aspects from their very basics\, such as molecular level\, up to entire neuronal networks.\nPhotopharmacology has proven to be advantageous for spatial and temporal control of biological processes without interfering the system natural dynamics and outcomes. Physiology can be tuned with photomimetic ligands and naturally occurring complex network responses can be segmented into light dependent activities discerning relevant data from a vast matrix of results. As these new tools are broadly used for biomedical purposes and most of them focused towards medical applications\, an interpretative analytical platform is needed to screen and identify potential photoswitchable molecules. \nZebrafish (Danio rerio) larvae constitute an excellent animal model for studying and screening photoswitchable molecules in vivo. Zebrafish present a transparent body during larval stages\, and therefore are capable of receiving specific and determined light applications. From the 19th hour post fertilisation they acquire behavioural traits\, from spontaneous twisting movements to full swimming capacities\, which are easily traceable and measurable. The use of up to 96 animals simultaneously allows a parallel high throughput data recovery system to analyse high complexity movements and behaviours\, all of it with the use of photopharmacology. Here\, we aimed at introducing an effective and reliable methodology for high throughput screening of photoswitchable compounds\, including photopharmacological derivatives or peptidoswitches\, for any in vivo possible target\, from specific neuronal correlated diseases up to possible toxicological outcomes. We focused on the study of the main inhibitory neuronal pathways and their locomotion outcomes on a reliable and comparable animal model. \nHence\, several photoswitchable compounds with a common benzodiazepine core and an azobenzene photoswitchable moiety were tested. A first light dependent activity ratio was applied in order to discern the most promising candidates. We identified the UR-DW290 molecule as a light dependent trigger of activity in larvae zebrafish. Larvae zebrafish treated with UR-DW290 maintained higher activity in terms of swimming distance (mm) during the relaxation period and UV-Blue light cycles in comparison to controls. Whole-cell recordings of GABAA and glycine mediated currents by URDW290 showed a potentiating of inhibition when irradiated with ultraviolet light in comparison to visible light illumination. \nWe propose the combination of high through-put screening and optopharmacology tools for the study and characterisation of zebrafish larvae behaviour focusing on their swimming activity. We identified a first photoswitchable molecule for glycine receptor modulation in vitro and in vivo\, UR-DW290\, which increases basal activity in zebrafish larvae. This increase is tuneable with UV and Blue light illumniation.
URL:https://ibecbarcelona.eu/Anna+Vila+and+Alexandre+Gomila
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181026T100000
DTEND;TZID=Europe/Madrid:20181026T110000
DTSTAMP:20260403T200517
CREATED:20181019T082001Z
LAST-MODIFIED:20181019T082001Z
UID:96329-1540548000-1540551600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Anna Vila and Alexandre Gomila
DESCRIPTION:Engineering of 3D Small Intestinal Mucosa Models\nAnna Vila\, Biomimetic Systems for Cell Engineering\nHydrogels have been used as a scaffold for engineering tissue-like structures due to their biocompatibility and properties similar to the extracellular matrix. There are two main types of hydrogels (i) natural hydrogels\, such as gelatin\, which are biodegradable and present cell adhesion motifs and (ii) synthetic hydrogels\, such as poly(ethylene glycol) diacrylate (PEGDA)\, which are non-biodegradable and can withstand long-term cell cultures but do not have bioadhesion sequences [El-Sherbiny M.I. et al.\, 2013]. Both types of hydrogels present complementary benefits. \nFor this reason\, we fabricated a hydrogel co-polymer composed of gelatin methacrylate (GelMA) co-polymerized with PEGDA [Hutson. B.C. et al.\, 2011]. We employed a single-step\, moldless\, UV-photolithography-based fabrication technique [Castaño A. et al.\, submitted] to fabricate scaffolds mimicking the 3D architecture of the small intestinal mucosa. Using this approach\, we obtained hydrogel co-polymers with finger-like microstructures\, with the roundness and dimensions found in the villi of the native tissue. Mechanical and physicochemical properties such as an approach of the Young’s modulus\, degradation rate and swelling ratio of the hydrogels have been characterized. Adding PEGDA to the GelMA hydrogels have provided hydrogels with lower degradation and higher Young’s modulus\, which ca be easily tuned by changing the composition of GelMA and PEGDA polymers. Furthermore\, we have demonstrated that our scaffolds support the growth and differentiation of intestinal epithelial Caco-2 cells up to 21 days\, obtaining a matured epithelial monolayer with effective tissue barrier properties. \nAdditionally\, we increased the complexity of our model of the small intestinal mucosa by incorporating an additional cell compartment to mimic the stroma of the in vivo tissue. To do that\, we embedded 3T3-NIH fibroblasts in our scaffolds during the photopolymerization procedure. Then\, we cultured Caco-2 cells on top of the 3T3-NIH fibroblast-laden hydrogels up to 21 days. Our preliminary results showed that the co-culture of Caco-2 cells with 3T3-NIH fibroblasts favours the epithelial cell growth and improves their barrier function. Taking all together\, we have generated an intestinal mucosa model that allows for the co-culture of different intestinal cell types distributed in compartments\, mimicking the spatial-physiological features of the small intestinal mucosa. We believe our model better recapitulates cell-cell crosstalk and cell-matrix interactions found in vivo\, being an improved alternative for the cell-base in vitro assays. \n  \nIn vivo photomodulation of GABA and Glycine receptor channels\nAlexandre Gomila\, Nanoprobes and Nanoswitches\nNeuronal networks are highly complex interactions\, which determine even the finest behaviour. The major inhibitory pathways in the central nervous system (CNS) act through chloride ion flux\, which are mostly driven by fast-acting ionotropic GABAA and Glycine receptors (GlyR). All of them share structural similarities and belong to pentameric ligand-gated ion channels of the Cys-loop family. Photoswitchable molecules have become a powerful tool in any applied field of bioscience\, and are broadly used in biomedical research due to their capacity for enlightening biological aspects from their very basics\, such as molecular level\, up to entire neuronal networks.\nPhotopharmacology has proven to be advantageous for spatial and temporal control of biological processes without interfering the system natural dynamics and outcomes. Physiology can be tuned with photomimetic ligands and naturally occurring complex network responses can be segmented into light dependent activities discerning relevant data from a vast matrix of results. As these new tools are broadly used for biomedical purposes and most of them focused towards medical applications\, an interpretative analytical platform is needed to screen and identify potential photoswitchable molecules. \nZebrafish (Danio rerio) larvae constitute an excellent animal model for studying and screening photoswitchable molecules in vivo. Zebrafish present a transparent body during larval stages\, and therefore are capable of receiving specific and determined light applications. From the 19th hour post fertilisation they acquire behavioural traits\, from spontaneous twisting movements to full swimming capacities\, which are easily traceable and measurable. The use of up to 96 animals simultaneously allows a parallel high throughput data recovery system to analyse high complexity movements and behaviours\, all of it with the use of photopharmacology. Here\, we aimed at introducing an effective and reliable methodology for high throughput screening of photoswitchable compounds\, including photopharmacological derivatives or peptidoswitches\, for any in vivo possible target\, from specific neuronal correlated diseases up to possible toxicological outcomes. We focused on the study of the main inhibitory neuronal pathways and their locomotion outcomes on a reliable and comparable animal model. \nHence\, several photoswitchable compounds with a common benzodiazepine core and an azobenzene photoswitchable moiety were tested. A first light dependent activity ratio was applied in order to discern the most promising candidates. We identified the UR-DW290 molecule as a light dependent trigger of activity in larvae zebrafish. Larvae zebrafish treated with UR-DW290 maintained higher activity in terms of swimming distance (mm) during the relaxation period and UV-Blue light cycles in comparison to controls. Whole-cell recordings of GABAA and glycine mediated currents by URDW290 showed a potentiating of inhibition when irradiated with ultraviolet light in comparison to visible light illumination. \nWe propose the combination of high through-put screening and optopharmacology tools for the study and characterisation of zebrafish larvae behaviour focusing on their swimming activity. We identified a first photoswitchable molecule for glycine receptor modulation in vitro and in vivo\, UR-DW290\, which increases basal activity in zebrafish larvae. This increase is tuneable with UV and Blue light illumniation.
URL:https://ibecbarcelona.eu/Anna+Vila+and+Alexandre+Gomila
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181026T100000
DTEND;TZID=Europe/Madrid:20181026T110000
DTSTAMP:20260403T200517
CREATED:20181019T082001Z
LAST-MODIFIED:20181019T082001Z
UID:96323-1540548000-1540551600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Anna Vila and Alexandre Gomila
DESCRIPTION:Engineering of 3D Small Intestinal Mucosa Models\nAnna Vila\, Biomimetic Systems for Cell Engineering\nHydrogels have been used as a scaffold for engineering tissue-like structures due to their biocompatibility and properties similar to the extracellular matrix. There are two main types of hydrogels (i) natural hydrogels\, such as gelatin\, which are biodegradable and present cell adhesion motifs and (ii) synthetic hydrogels\, such as poly(ethylene glycol) diacrylate (PEGDA)\, which are non-biodegradable and can withstand long-term cell cultures but do not have bioadhesion sequences [El-Sherbiny M.I. et al.\, 2013]. Both types of hydrogels present complementary benefits. \nFor this reason\, we fabricated a hydrogel co-polymer composed of gelatin methacrylate (GelMA) co-polymerized with PEGDA [Hutson. B.C. et al.\, 2011]. We employed a single-step\, moldless\, UV-photolithography-based fabrication technique [Castaño A. et al.\, submitted] to fabricate scaffolds mimicking the 3D architecture of the small intestinal mucosa. Using this approach\, we obtained hydrogel co-polymers with finger-like microstructures\, with the roundness and dimensions found in the villi of the native tissue. Mechanical and physicochemical properties such as an approach of the Young’s modulus\, degradation rate and swelling ratio of the hydrogels have been characterized. Adding PEGDA to the GelMA hydrogels have provided hydrogels with lower degradation and higher Young’s modulus\, which ca be easily tuned by changing the composition of GelMA and PEGDA polymers. Furthermore\, we have demonstrated that our scaffolds support the growth and differentiation of intestinal epithelial Caco-2 cells up to 21 days\, obtaining a matured epithelial monolayer with effective tissue barrier properties. \nAdditionally\, we increased the complexity of our model of the small intestinal mucosa by incorporating an additional cell compartment to mimic the stroma of the in vivo tissue. To do that\, we embedded 3T3-NIH fibroblasts in our scaffolds during the photopolymerization procedure. Then\, we cultured Caco-2 cells on top of the 3T3-NIH fibroblast-laden hydrogels up to 21 days. Our preliminary results showed that the co-culture of Caco-2 cells with 3T3-NIH fibroblasts favours the epithelial cell growth and improves their barrier function. Taking all together\, we have generated an intestinal mucosa model that allows for the co-culture of different intestinal cell types distributed in compartments\, mimicking the spatial-physiological features of the small intestinal mucosa. We believe our model better recapitulates cell-cell crosstalk and cell-matrix interactions found in vivo\, being an improved alternative for the cell-base in vitro assays. \n  \nIn vivo photomodulation of GABA and Glycine receptor channels\nAlexandre Gomila\, Nanoprobes and Nanoswitches\nNeuronal networks are highly complex interactions\, which determine even the finest behaviour. The major inhibitory pathways in the central nervous system (CNS) act through chloride ion flux\, which are mostly driven by fast-acting ionotropic GABAA and Glycine receptors (GlyR). All of them share structural similarities and belong to pentameric ligand-gated ion channels of the Cys-loop family. Photoswitchable molecules have become a powerful tool in any applied field of bioscience\, and are broadly used in biomedical research due to their capacity for enlightening biological aspects from their very basics\, such as molecular level\, up to entire neuronal networks.\nPhotopharmacology has proven to be advantageous for spatial and temporal control of biological processes without interfering the system natural dynamics and outcomes. Physiology can be tuned with photomimetic ligands and naturally occurring complex network responses can be segmented into light dependent activities discerning relevant data from a vast matrix of results. As these new tools are broadly used for biomedical purposes and most of them focused towards medical applications\, an interpretative analytical platform is needed to screen and identify potential photoswitchable molecules. \nZebrafish (Danio rerio) larvae constitute an excellent animal model for studying and screening photoswitchable molecules in vivo. Zebrafish present a transparent body during larval stages\, and therefore are capable of receiving specific and determined light applications. From the 19th hour post fertilisation they acquire behavioural traits\, from spontaneous twisting movements to full swimming capacities\, which are easily traceable and measurable. The use of up to 96 animals simultaneously allows a parallel high throughput data recovery system to analyse high complexity movements and behaviours\, all of it with the use of photopharmacology. Here\, we aimed at introducing an effective and reliable methodology for high throughput screening of photoswitchable compounds\, including photopharmacological derivatives or peptidoswitches\, for any in vivo possible target\, from specific neuronal correlated diseases up to possible toxicological outcomes. We focused on the study of the main inhibitory neuronal pathways and their locomotion outcomes on a reliable and comparable animal model. \nHence\, several photoswitchable compounds with a common benzodiazepine core and an azobenzene photoswitchable moiety were tested. A first light dependent activity ratio was applied in order to discern the most promising candidates. We identified the UR-DW290 molecule as a light dependent trigger of activity in larvae zebrafish. Larvae zebrafish treated with UR-DW290 maintained higher activity in terms of swimming distance (mm) during the relaxation period and UV-Blue light cycles in comparison to controls. Whole-cell recordings of GABAA and glycine mediated currents by URDW290 showed a potentiating of inhibition when irradiated with ultraviolet light in comparison to visible light illumination. \nWe propose the combination of high through-put screening and optopharmacology tools for the study and characterisation of zebrafish larvae behaviour focusing on their swimming activity. We identified a first photoswitchable molecule for glycine receptor modulation in vitro and in vivo\, UR-DW290\, which increases basal activity in zebrafish larvae. This increase is tuneable with UV and Blue light illumniation.
URL:https://ibecbarcelona.eu/Anna+Vila+and+Alexandre+Gomila
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181026T100000
DTEND;TZID=Europe/Madrid:20181026T110000
DTSTAMP:20260403T200517
CREATED:20181019T082001Z
LAST-MODIFIED:20181019T082001Z
UID:96328-1540548000-1540551600@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Anna Vila and Alexandre Gomila
DESCRIPTION:Engineering of 3D Small Intestinal Mucosa Models\nAnna Vila\, Biomimetic Systems for Cell Engineering\nHydrogels have been used as a scaffold for engineering tissue-like structures due to their biocompatibility and properties similar to the extracellular matrix. There are two main types of hydrogels (i) natural hydrogels\, such as gelatin\, which are biodegradable and present cell adhesion motifs and (ii) synthetic hydrogels\, such as poly(ethylene glycol) diacrylate (PEGDA)\, which are non-biodegradable and can withstand long-term cell cultures but do not have bioadhesion sequences [El-Sherbiny M.I. et al.\, 2013]. Both types of hydrogels present complementary benefits. \nFor this reason\, we fabricated a hydrogel co-polymer composed of gelatin methacrylate (GelMA) co-polymerized with PEGDA [Hutson. B.C. et al.\, 2011]. We employed a single-step\, moldless\, UV-photolithography-based fabrication technique [Castaño A. et al.\, submitted] to fabricate scaffolds mimicking the 3D architecture of the small intestinal mucosa. Using this approach\, we obtained hydrogel co-polymers with finger-like microstructures\, with the roundness and dimensions found in the villi of the native tissue. Mechanical and physicochemical properties such as an approach of the Young’s modulus\, degradation rate and swelling ratio of the hydrogels have been characterized. Adding PEGDA to the GelMA hydrogels have provided hydrogels with lower degradation and higher Young’s modulus\, which ca be easily tuned by changing the composition of GelMA and PEGDA polymers. Furthermore\, we have demonstrated that our scaffolds support the growth and differentiation of intestinal epithelial Caco-2 cells up to 21 days\, obtaining a matured epithelial monolayer with effective tissue barrier properties. \nAdditionally\, we increased the complexity of our model of the small intestinal mucosa by incorporating an additional cell compartment to mimic the stroma of the in vivo tissue. To do that\, we embedded 3T3-NIH fibroblasts in our scaffolds during the photopolymerization procedure. Then\, we cultured Caco-2 cells on top of the 3T3-NIH fibroblast-laden hydrogels up to 21 days. Our preliminary results showed that the co-culture of Caco-2 cells with 3T3-NIH fibroblasts favours the epithelial cell growth and improves their barrier function. Taking all together\, we have generated an intestinal mucosa model that allows for the co-culture of different intestinal cell types distributed in compartments\, mimicking the spatial-physiological features of the small intestinal mucosa. We believe our model better recapitulates cell-cell crosstalk and cell-matrix interactions found in vivo\, being an improved alternative for the cell-base in vitro assays. \n  \nIn vivo photomodulation of GABA and Glycine receptor channels\nAlexandre Gomila\, Nanoprobes and Nanoswitches\nNeuronal networks are highly complex interactions\, which determine even the finest behaviour. The major inhibitory pathways in the central nervous system (CNS) act through chloride ion flux\, which are mostly driven by fast-acting ionotropic GABAA and Glycine receptors (GlyR). All of them share structural similarities and belong to pentameric ligand-gated ion channels of the Cys-loop family. Photoswitchable molecules have become a powerful tool in any applied field of bioscience\, and are broadly used in biomedical research due to their capacity for enlightening biological aspects from their very basics\, such as molecular level\, up to entire neuronal networks.\nPhotopharmacology has proven to be advantageous for spatial and temporal control of biological processes without interfering the system natural dynamics and outcomes. Physiology can be tuned with photomimetic ligands and naturally occurring complex network responses can be segmented into light dependent activities discerning relevant data from a vast matrix of results. As these new tools are broadly used for biomedical purposes and most of them focused towards medical applications\, an interpretative analytical platform is needed to screen and identify potential photoswitchable molecules. \nZebrafish (Danio rerio) larvae constitute an excellent animal model for studying and screening photoswitchable molecules in vivo. Zebrafish present a transparent body during larval stages\, and therefore are capable of receiving specific and determined light applications. From the 19th hour post fertilisation they acquire behavioural traits\, from spontaneous twisting movements to full swimming capacities\, which are easily traceable and measurable. The use of up to 96 animals simultaneously allows a parallel high throughput data recovery system to analyse high complexity movements and behaviours\, all of it with the use of photopharmacology. Here\, we aimed at introducing an effective and reliable methodology for high throughput screening of photoswitchable compounds\, including photopharmacological derivatives or peptidoswitches\, for any in vivo possible target\, from specific neuronal correlated diseases up to possible toxicological outcomes. We focused on the study of the main inhibitory neuronal pathways and their locomotion outcomes on a reliable and comparable animal model. \nHence\, several photoswitchable compounds with a common benzodiazepine core and an azobenzene photoswitchable moiety were tested. A first light dependent activity ratio was applied in order to discern the most promising candidates. We identified the UR-DW290 molecule as a light dependent trigger of activity in larvae zebrafish. Larvae zebrafish treated with UR-DW290 maintained higher activity in terms of swimming distance (mm) during the relaxation period and UV-Blue light cycles in comparison to controls. Whole-cell recordings of GABAA and glycine mediated currents by URDW290 showed a potentiating of inhibition when irradiated with ultraviolet light in comparison to visible light illumination. \nWe propose the combination of high through-put screening and optopharmacology tools for the study and characterisation of zebrafish larvae behaviour focusing on their swimming activity. We identified a first photoswitchable molecule for glycine receptor modulation in vitro and in vivo\, UR-DW290\, which increases basal activity in zebrafish larvae. This increase is tuneable with UV and Blue light illumniation.
URL:https://ibecbarcelona.eu/Anna+Vila+and+Alexandre+Gomila
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181025T160000
DTEND;TZID=Europe/Madrid:20181025T170000
DTSTAMP:20260403T200517
CREATED:20181022T110725Z
LAST-MODIFIED:20181022T110725Z
UID:96330-1540483200-1540486800@ibecbarcelona.eu
SUMMARY:IN2UB International Research Seminars: Pere Roca-Cusachs
DESCRIPTION:IBEC group leader Pere Roca-Cusachs is the speaker at the inaugural seminar of the new IN2UB International Research Seminar series. \nSensing the matrix: transducing mechanical signals from integrins to the nucleus\nPere Roca-Cusachs\, IBEC\nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\,are strongly determined by the properties of the extra cellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to the activation of the transcriptional regulator YAP. \n 
URL:https://ibecbarcelona.eu/event/in2ub-international-research-seminars-pere-roca-cusachs-3/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181025T160000
DTEND;TZID=Europe/Madrid:20181025T170000
DTSTAMP:20260403T200517
CREATED:20181022T110725Z
LAST-MODIFIED:20181022T110725Z
UID:96331-1540483200-1540486800@ibecbarcelona.eu
SUMMARY:IN2UB International Research Seminars: Pere Roca-Cusachs
DESCRIPTION:IBEC group leader Pere Roca-Cusachs is the speaker at the inaugural seminar of the new IN2UB International Research Seminar series. \nSensing the matrix: transducing mechanical signals from integrins to the nucleus\nPere Roca-Cusachs\, IBEC\nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\,are strongly determined by the properties of the extra cellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to the activation of the transcriptional regulator YAP. \n 
URL:https://ibecbarcelona.eu/event/in2ub-international-research-seminars-pere-roca-cusachs-4/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181025T160000
DTEND;TZID=Europe/Madrid:20181025T170000
DTSTAMP:20260403T200517
CREATED:20181022T110725Z
LAST-MODIFIED:20181022T111002Z
UID:62160-1540483200-1540486800@ibecbarcelona.eu
SUMMARY:IN2UB International Research Seminars: Pere Roca-Cusachs
DESCRIPTION:IBEC group leader Pere Roca-Cusachs is the speaker at the inaugural seminar of the new IN2UB International Research Seminar series. \nSensing the matrix: transducing mechanical signals from integrins to the nucleus\nPere Roca-Cusachs\, IBEC\nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\,are strongly determined by the properties of the extra cellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to the activation of the transcriptional regulator YAP. \n 
URL:https://ibecbarcelona.eu/event/in2ub-international-research-seminars-pere-roca-cusachs/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:External seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181025T160000
DTEND;TZID=Europe/Madrid:20181025T170000
DTSTAMP:20260403T200517
CREATED:20181022T110725Z
LAST-MODIFIED:20181022T110725Z
UID:96324-1540483200-1540486800@ibecbarcelona.eu
SUMMARY:IN2UB International Research Seminars: Pere Roca-Cusachs
DESCRIPTION:IBEC group leader Pere Roca-Cusachs is the speaker at the inaugural seminar of the new IN2UB International Research Seminar series. \nSensing the matrix: transducing mechanical signals from integrins to the nucleus\nPere Roca-Cusachs\, IBEC\nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\,are strongly determined by the properties of the extra cellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to the activation of the transcriptional regulator YAP. \n 
URL:https://ibecbarcelona.eu/event/in2ub-international-research-seminars-pere-roca-cusachs-2/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:External seminar
END:VEVENT
END:VCALENDAR