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DTSTART;TZID=Europe/Madrid:20220427T000000
DTEND;TZID=Europe/Madrid:20220427T130000
DTSTAMP:20260403T192601
CREATED:20220314T110017Z
LAST-MODIFIED:20220314T110017Z
UID:96556-1651017600-1651064400@ibecbarcelona.eu
SUMMARY:Open BIST Seminar: Dr. Wiktor Szymanski
DESCRIPTION:Molecular basis for the use of light in medicine\nWiktor Szymanski\, Medical Imaging Center\, University Medical Center Groningen \nLight is a unique control element in chemistry and biology\, because it can be safely delivered with very high precision to modulate processes in space and time. In this educational lecture\, aimed at Master students but hopefully of interest to all academics\, I will discuss the main processes that a molecule can undergo once it has been promoted to the excited state under light irradiation. Using the Jablonski diagram as the starting point\, I will outline how these processes are or could be used in the clinic for diagnostics (optical and optoacoustic imaging) and therapy (photodynamic therapy and photopharmacology). \n\nWiktor Szymanski received his PhD degree from The Warsaw University of Technology\, Poland\, in 2008\, working under the supervision of Prof. Ryszard Ostaszewski. He spent two years working on the use of biotransformations in organic chemistry with Prof. Ben L. Feringa and Prof. Dick B. Janssen at the University of Groningen. Since 2010 he has been working on the construction of photoactive protein- peptide- and DNA-bioconjugates and photopharmacology in the Feringa Labs. In 2014\, he joined the Medical Imaging Center\, University Medical Center Groningen\, where he was appointed in 2015 as tenure track assistant professor and in 2019 as associate professor (adjunct hoogleraar).
URL:https://ibecbarcelona.eu/event/open-bist-seminar-dr-wiktor-szymanski-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220427T000000
DTEND;TZID=Europe/Madrid:20220427T130000
DTSTAMP:20260403T192601
CREATED:20220314T110017Z
LAST-MODIFIED:20220314T110017Z
UID:96560-1651017600-1651064400@ibecbarcelona.eu
SUMMARY:Open BIST Seminar: Dr. Wiktor Szymanski
DESCRIPTION:Molecular basis for the use of light in medicine\nWiktor Szymanski\, Medical Imaging Center\, University Medical Center Groningen \nLight is a unique control element in chemistry and biology\, because it can be safely delivered with very high precision to modulate processes in space and time. In this educational lecture\, aimed at Master students but hopefully of interest to all academics\, I will discuss the main processes that a molecule can undergo once it has been promoted to the excited state under light irradiation. Using the Jablonski diagram as the starting point\, I will outline how these processes are or could be used in the clinic for diagnostics (optical and optoacoustic imaging) and therapy (photodynamic therapy and photopharmacology). \n\nWiktor Szymanski received his PhD degree from The Warsaw University of Technology\, Poland\, in 2008\, working under the supervision of Prof. Ryszard Ostaszewski. He spent two years working on the use of biotransformations in organic chemistry with Prof. Ben L. Feringa and Prof. Dick B. Janssen at the University of Groningen. Since 2010 he has been working on the construction of photoactive protein- peptide- and DNA-bioconjugates and photopharmacology in the Feringa Labs. In 2014\, he joined the Medical Imaging Center\, University Medical Center Groningen\, where he was appointed in 2015 as tenure track assistant professor and in 2019 as associate professor (adjunct hoogleraar).
URL:https://ibecbarcelona.eu/event/open-bist-seminar-dr-wiktor-szymanski-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220427T000000
DTEND;TZID=Europe/Madrid:20220427T130000
DTSTAMP:20260403T192601
CREATED:20220314T110017Z
LAST-MODIFIED:20220314T110017Z
UID:90931-1651017600-1651064400@ibecbarcelona.eu
SUMMARY:Open BIST Seminar: Dr. Wiktor Szymanski
DESCRIPTION:Molecular basis for the use of light in medicine\nWiktor Szymanski\, Medical Imaging Center\, University Medical Center Groningen \nLight is a unique control element in chemistry and biology\, because it can be safely delivered with very high precision to modulate processes in space and time. In this educational lecture\, aimed at Master students but hopefully of interest to all academics\, I will discuss the main processes that a molecule can undergo once it has been promoted to the excited state under light irradiation. Using the Jablonski diagram as the starting point\, I will outline how these processes are or could be used in the clinic for diagnostics (optical and optoacoustic imaging) and therapy (photodynamic therapy and photopharmacology). \n\nWiktor Szymanski received his PhD degree from The Warsaw University of Technology\, Poland\, in 2008\, working under the supervision of Prof. Ryszard Ostaszewski. He spent two years working on the use of biotransformations in organic chemistry with Prof. Ben L. Feringa and Prof. Dick B. Janssen at the University of Groningen. Since 2010 he has been working on the construction of photoactive protein- peptide- and DNA-bioconjugates and photopharmacology in the Feringa Labs. In 2014\, he joined the Medical Imaging Center\, University Medical Center Groningen\, where he was appointed in 2015 as tenure track assistant professor and in 2019 as associate professor (adjunct hoogleraar).
URL:https://ibecbarcelona.eu/event/open-bist-seminar-dr-wiktor-szymanski-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220427T100000
DTEND;TZID=Europe/Madrid:20220430T150000
DTSTAMP:20260403T192601
CREATED:20220503T144700Z
LAST-MODIFIED:20220503T144701Z
UID:94016-1651053600-1651330800@ibecbarcelona.eu
SUMMARY:Fira Recerca en Directe 2022
DESCRIPTION:Fira Recerca en Directe\n\n\n\n\n\n\n\nLa Fira Recerca en Directe es planteja com a un tastet de projectes de recerca que estan en curs sobre diferents disciplines amb un format de proximitat\, on es presenta l’oportunitat de parlar cara a cara amb els mateixos investigadors\, així com de realitzar petits experiments amb la instrumentació científica i part del laboratori que desplacen fins a la Fira. \n\n\n\nVa néixer el 2003 per establir un canal de comunicació on es pogués transmetre a la població el mètode científic i la recerca que es porta a terme als laboratoris de tot Catalunya. \n\n\n\nParticipa el grup de “Nanobioenginyeria” amb un stand on parlaràn sobre les nanopartícules i com viatgen pel nostre cos.
URL:https://ibecbarcelona.eu/event/fira-recerca-en-directe-2022/
LOCATION:CosmoCaixa
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220427T120000
DTEND;TZID=Europe/Madrid:20220427T130000
DTSTAMP:20260403T192601
CREATED:20220503T143816Z
LAST-MODIFIED:20220503T143818Z
UID:94013-1651060800-1651064400@ibecbarcelona.eu
SUMMARY:Open BIST Seminar: Dr. Wiktor Szymanski
DESCRIPTION:Molecular basis for the use of light in medicine\n\n\n\nWiktor Szymanski\, Medical Imaging Center\, University Medical Center Groningen \n\n\n\nLight is a unique control element in chemistry and biology\, because it can be safely delivered with very high precision to modulate processes in space and time. In this educational lecture\, aimed at Master students but hopefully of interest to all academics\, I will discuss the main processes that a molecule can undergo once it has been promoted to the excited state under light irradiation. Using the Jablonski diagram as the starting point\, I will outline how these processes are or could be used in the clinic for diagnostics (optical and optoacoustic imaging) and therapy (photodynamic therapy and photopharmacology). \n\n\n\n\n\n\n\nWiktor Szymanski received his PhD degree from The Warsaw University of Technology\, Poland\, in 2008\, working under the supervision of Prof. Ryszard Ostaszewski. He spent two years working on the use of biotransformations in organic chemistry with Prof. Ben L. Feringa and Prof. Dick B. Janssen at the University of Groningen. Since 2010 he has been working on the construction of photoactive protein- peptide- and DNA-bioconjugates and photopharmacology in the Feringa Labs. In 2014\, he joined the Medical Imaging Center\, University Medical Center Groningen\, where he was appointed in 2015 as tenure track assistant professor and in 2019 as associate professor (adjunct hoogleraar).
URL:https://ibecbarcelona.eu/event/open-bist-seminar-dr-wiktor-szymanski/
LOCATION:IBEC\, floor 11\, tower i
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220429T100000
DTEND;TZID=Europe/Madrid:20220429T120000
DTSTAMP:20260403T192601
CREATED:20220422T065109Z
LAST-MODIFIED:20220422T065109Z
UID:96589-1651226400-1651233600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Sefora Conti
DESCRIPTION:Mechanical phenotyping of colorectal cancer patient derived organoids based on LGR5 expression\nSefora Conti\, Integrative cell and tissue dynamics group \nColorectal cancer (CRC) tumors are composed by heterogeneous cell populations comprising differentiated cells and a small pool of cancer stem cells (CSCs). The link between cancer cell differentiation states and their metastatic potential has been the focus of extensive investigation\, with some studies pointing to microenvironmentally defined plasticity as a mechanism indispensable for metastasis formation. Another aspect that might be determinant in tumor cells ability to successfully disseminate\, intravasate\, survive in the blood stream\, extravasate\, colonize distant organs and form secondary tumors is their mechanical phenotype. \nAdopting a bottom-up approach\, we performed a broad biophysical characterization of CRC patient derived organoids (PDOs)\, engineered to fluorescently label cells expressing LGR5\, a well-established marker for CSCs. We show that CRC cells differentiation states are associated with distinct biomechanical phenotypes\, with potential repercussions on their metastatic ability. \nAt the single cell level\, LGR5+ cells display a more elongated and polarized shape while the LGR5- cells exhibit higher roundness and a smaller asymmetry in the stress field. LGR5+ are stiffer compared to their differentiated counterparts and more prone to adopt a fast amoeboid-like migration under confinement.  At the molecular level\, cancer stemness is related to differential expression of the ERM protein family\, responsible of tethering the cell membrane to the underlying actin cortex. \nThese distinct mechanical phenotypes translate to different migratory and morphological phenotypes at a cluster level. Clusters expressing high levels of LGR5 showed a more spread and flattened shape compared to more differentiated clusters. Moreover\, LGR5 expression in clusters is negatively correlated with their migration speed and their polarization state. Hence\, clusters containing more differentiated cells migrate faster\, display higher roundness and higher polarization state. \nAt higher complexity levels\, such as interactions with endothelial cells\, LGR5 expression in CRC clusters affects their ability to adhere to an endothelial monolayer and form a gap through which they attach to the underlying collagen coating. Notably\, we found that clusters expressing more LGR5 have an advantage while attaching to the endothelium as indicated by higher attachment rate and shorter time to form a gap. \nBased on these findings relating distinct mechanical phenotypes to LGR5 expression\, we speculate that mechanical adaptability coupled with cancer plasticity may be an indispensable mechanism for cancer progression.
URL:https://ibecbarcelona.eu/event/phd-discussions-sefora-conti-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220429T100000
DTEND;TZID=Europe/Madrid:20220429T120000
DTSTAMP:20260403T192601
CREATED:20220422T065109Z
LAST-MODIFIED:20220422T065109Z
UID:96592-1651226400-1651233600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Sefora Conti
DESCRIPTION:Mechanical phenotyping of colorectal cancer patient derived organoids based on LGR5 expression\nSefora Conti\, Integrative cell and tissue dynamics group \nColorectal cancer (CRC) tumors are composed by heterogeneous cell populations comprising differentiated cells and a small pool of cancer stem cells (CSCs). The link between cancer cell differentiation states and their metastatic potential has been the focus of extensive investigation\, with some studies pointing to microenvironmentally defined plasticity as a mechanism indispensable for metastasis formation. Another aspect that might be determinant in tumor cells ability to successfully disseminate\, intravasate\, survive in the blood stream\, extravasate\, colonize distant organs and form secondary tumors is their mechanical phenotype. \nAdopting a bottom-up approach\, we performed a broad biophysical characterization of CRC patient derived organoids (PDOs)\, engineered to fluorescently label cells expressing LGR5\, a well-established marker for CSCs. We show that CRC cells differentiation states are associated with distinct biomechanical phenotypes\, with potential repercussions on their metastatic ability. \nAt the single cell level\, LGR5+ cells display a more elongated and polarized shape while the LGR5- cells exhibit higher roundness and a smaller asymmetry in the stress field. LGR5+ are stiffer compared to their differentiated counterparts and more prone to adopt a fast amoeboid-like migration under confinement.  At the molecular level\, cancer stemness is related to differential expression of the ERM protein family\, responsible of tethering the cell membrane to the underlying actin cortex. \nThese distinct mechanical phenotypes translate to different migratory and morphological phenotypes at a cluster level. Clusters expressing high levels of LGR5 showed a more spread and flattened shape compared to more differentiated clusters. Moreover\, LGR5 expression in clusters is negatively correlated with their migration speed and their polarization state. Hence\, clusters containing more differentiated cells migrate faster\, display higher roundness and higher polarization state. \nAt higher complexity levels\, such as interactions with endothelial cells\, LGR5 expression in CRC clusters affects their ability to adhere to an endothelial monolayer and form a gap through which they attach to the underlying collagen coating. Notably\, we found that clusters expressing more LGR5 have an advantage while attaching to the endothelium as indicated by higher attachment rate and shorter time to form a gap. \nBased on these findings relating distinct mechanical phenotypes to LGR5 expression\, we speculate that mechanical adaptability coupled with cancer plasticity may be an indispensable mechanism for cancer progression.
URL:https://ibecbarcelona.eu/event/phd-discussions-sefora-conti-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220429T100000
DTEND;TZID=Europe/Madrid:20220429T120000
DTSTAMP:20260403T192601
CREATED:20220422T065109Z
LAST-MODIFIED:20220422T065109Z
UID:96593-1651226400-1651233600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Sefora Conti
DESCRIPTION:Mechanical phenotyping of colorectal cancer patient derived organoids based on LGR5 expression\nSefora Conti\, Integrative cell and tissue dynamics group \nColorectal cancer (CRC) tumors are composed by heterogeneous cell populations comprising differentiated cells and a small pool of cancer stem cells (CSCs). The link between cancer cell differentiation states and their metastatic potential has been the focus of extensive investigation\, with some studies pointing to microenvironmentally defined plasticity as a mechanism indispensable for metastasis formation. Another aspect that might be determinant in tumor cells ability to successfully disseminate\, intravasate\, survive in the blood stream\, extravasate\, colonize distant organs and form secondary tumors is their mechanical phenotype. \nAdopting a bottom-up approach\, we performed a broad biophysical characterization of CRC patient derived organoids (PDOs)\, engineered to fluorescently label cells expressing LGR5\, a well-established marker for CSCs. We show that CRC cells differentiation states are associated with distinct biomechanical phenotypes\, with potential repercussions on their metastatic ability. \nAt the single cell level\, LGR5+ cells display a more elongated and polarized shape while the LGR5- cells exhibit higher roundness and a smaller asymmetry in the stress field. LGR5+ are stiffer compared to their differentiated counterparts and more prone to adopt a fast amoeboid-like migration under confinement.  At the molecular level\, cancer stemness is related to differential expression of the ERM protein family\, responsible of tethering the cell membrane to the underlying actin cortex. \nThese distinct mechanical phenotypes translate to different migratory and morphological phenotypes at a cluster level. Clusters expressing high levels of LGR5 showed a more spread and flattened shape compared to more differentiated clusters. Moreover\, LGR5 expression in clusters is negatively correlated with their migration speed and their polarization state. Hence\, clusters containing more differentiated cells migrate faster\, display higher roundness and higher polarization state. \nAt higher complexity levels\, such as interactions with endothelial cells\, LGR5 expression in CRC clusters affects their ability to adhere to an endothelial monolayer and form a gap through which they attach to the underlying collagen coating. Notably\, we found that clusters expressing more LGR5 have an advantage while attaching to the endothelium as indicated by higher attachment rate and shorter time to form a gap. \nBased on these findings relating distinct mechanical phenotypes to LGR5 expression\, we speculate that mechanical adaptability coupled with cancer plasticity may be an indispensable mechanism for cancer progression.
URL:https://ibecbarcelona.eu/event/phd-discussions-sefora-conti-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220509T183000
DTEND;TZID=Europe/Madrid:20220511T210000
DTSTAMP:20260403T192601
CREATED:20220504T115535Z
LAST-MODIFIED:20220504T115535Z
UID:96611-1652121000-1652302800@ibecbarcelona.eu
SUMMARY:Pint of Science 2022
DESCRIPTION:Monica Mir de Nanobioengineering\,  Agustín Gutierrez de Signal and Information Processing for Sensing Systems y  Silvia Pujals de Nanoscopy for nanomedicine participarán en el evento global de divulgación científica Pint of Science. \nEl festival Pint of Science\, que se celebrará del 09 al 11 de mayo\, tiene como objetivo ofrecer charlas interesantes\, divertidas y relevantes sobre las últimas investigaciones científicas de la mano de las personas que las llevan a cabo. \n  \nLunes\, 9 de mayo:  \n\nMonica Mir “¿Como funcionan los test para detección de COVID?”\nAgustín Gutierrez “Una nueva inteligencia para controlar el mundo”\n\nMartes 10 de mayo: \n\nSilvia Pujals “Nanopartículas para la medicina. ¿Promesa o realidad?”\n\n  \n\n\n\n\nSi quieres más información\, visita: Eventos de Barcelona | Pint of Science ES. \nPodéis ver el cartel aquí.
URL:https://ibecbarcelona.eu/event/pint-of-science-2022/
LOCATION:Careers at IBEC
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220509T183000
DTEND;TZID=Europe/Madrid:20220511T210000
DTSTAMP:20260403T192601
CREATED:20220504T115535Z
LAST-MODIFIED:20220504T115535Z
UID:96612-1652121000-1652302800@ibecbarcelona.eu
SUMMARY:Pint of Science 2022
DESCRIPTION:Monica Mir de Nanobioengineering\,  Agustín Gutierrez de Signal and Information Processing for Sensing Systems y  Silvia Pujals de Nanoscopy for nanomedicine participarán en el evento global de divulgación científica Pint of Science. \nEl festival Pint of Science\, que se celebrará del 09 al 11 de mayo\, tiene como objetivo ofrecer charlas interesantes\, divertidas y relevantes sobre las últimas investigaciones científicas de la mano de las personas que las llevan a cabo. \n  \nLunes\, 9 de mayo:  \n\nMonica Mir “¿Como funcionan los test para detección de COVID?”\nAgustín Gutierrez “Una nueva inteligencia para controlar el mundo”\n\nMartes 10 de mayo: \n\nSilvia Pujals “Nanopartículas para la medicina. ¿Promesa o realidad?”\n\n  \n\n\n\n\nSi quieres más información\, visita: Eventos de Barcelona | Pint of Science ES. \nPodéis ver el cartel aquí.
URL:https://ibecbarcelona.eu/event/pint-of-science-2022/
LOCATION:Careers at IBEC
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220509T183000
DTEND;TZID=Europe/Madrid:20220511T210000
DTSTAMP:20260403T192601
CREATED:20220504T115535Z
LAST-MODIFIED:20220504T115535Z
UID:96608-1652121000-1652302800@ibecbarcelona.eu
SUMMARY:Pint of Science 2022
DESCRIPTION:Monica Mir de Nanobioengineering\,  Agustín Gutierrez de Signal and Information Processing for Sensing Systems y  Silvia Pujals de Nanoscopy for nanomedicine participarán en el evento global de divulgación científica Pint of Science. \nEl festival Pint of Science\, que se celebrará del 09 al 11 de mayo\, tiene como objetivo ofrecer charlas interesantes\, divertidas y relevantes sobre las últimas investigaciones científicas de la mano de las personas que las llevan a cabo. \n  \nLunes\, 9 de mayo:  \n\nMonica Mir “¿Como funcionan los test para detección de COVID?”\nAgustín Gutierrez “Una nueva inteligencia para controlar el mundo”\n\nMartes 10 de mayo: \n\nSilvia Pujals “Nanopartículas para la medicina. ¿Promesa o realidad?”\n\n  \n\n\n\n\nSi quieres más información\, visita: Eventos de Barcelona | Pint of Science ES. \nPodéis ver el cartel aquí.
URL:https://ibecbarcelona.eu/event/pint-of-science-2022/
LOCATION:Careers at IBEC
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220512T101500
DTEND;TZID=Europe/Madrid:20220512T140000
DTSTAMP:20260403T192601
CREATED:20220419T073953Z
LAST-MODIFIED:20220419T073953Z
UID:96584-1652350500-1652364000@ibecbarcelona.eu
SUMMARY:Research4Talent 2022
DESCRIPTION:On Thursday 12th May 2022 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2021 IBEC signed more that 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s eighth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research4talent-2022/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220512T101500
DTEND;TZID=Europe/Madrid:20220512T140000
DTSTAMP:20260403T192601
CREATED:20220419T073953Z
LAST-MODIFIED:20220419T073953Z
UID:96585-1652350500-1652364000@ibecbarcelona.eu
SUMMARY:Research4Talent 2022
DESCRIPTION:On Thursday 12th May 2022 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2021 IBEC signed more that 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s eighth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research4talent-2022-2/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220512T101500
DTEND;TZID=Europe/Madrid:20220512T140000
DTSTAMP:20260403T192601
CREATED:20220419T073953Z
LAST-MODIFIED:20220419T073953Z
UID:96588-1652350500-1652364000@ibecbarcelona.eu
SUMMARY:Research4Talent 2022
DESCRIPTION:On Thursday 12th May 2022 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2021 IBEC signed more that 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s eighth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research4talent-2022-3/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220513T100000
DTEND;TZID=Europe/Madrid:20220513T120000
DTSTAMP:20260403T192601
CREATED:20220503T130848Z
LAST-MODIFIED:20220503T130848Z
UID:91647-1652436000-1652443200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Iris Batalha
DESCRIPTION:Nanotherapeutics – ‘How we sometimes underestimate the influence of little things’\nIris L. Batalha\, Institute for Bioengineering of Catalonia (IBEC) \nDeaths caused by infections from antibiotic-resistant bacteria are expected to skyrocket over the next decades\, with a staggering 10 million deaths per year projected for 2050. Treating infections by intracellular pathogens\, such as M. tuberculosis\, is ‘a perfect storm’. The WHO revealed that while some 50 new antibiotics and 10 biologics are under development\, only half of those target WHO-priority pathogens and the majority have very limited benefits when compared to existing antibiotics. Reformulating existent drugs in nanocarriers may help achieving enhanced efficacy and safety while reducing dose frequency\, by providing temporal and localised control of drug exposure. In this talk\, I will present my work on the synthesis of dual-drug tunable nanoparticle-based antibiotics\, which showed increased bacterial killing efficacy in a zebrafish larval model of mycobacterial infection when compared to free drugs at the same concentration. In addition\, nanoparticles were able to efficiently penetrate mycobacterial cords and granulomatous lesions – shielded regions of difficult access by free drugs\, improving the therapeutic effect. \n\nIris Batalha is currently a Junior Leader Research Fellow at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona\, a Panel Tutor in Nanotherapeutics at the University of Cambridge Institute of Continuing Education\, a freelance Senior Innovation Consultant at Inspiralia (Spain and USA)\, a Co-founder\, Director and Editor-in-Chief of the non-profit organisation Women Ahead of Their Time (WATT)\, and a Research Associate at Peterhouse College. From 2017 to 2020\, she was a joint Research Associate at the Department of Engineering Nanoscience Centre and Department of Medicine Molecular Immunity Unit\, University of Cambridge. From 2014 to 2017\, she worked at the Department of Chemical Engineering and Biotechnology\, University of Cambridge\, and the biopharmaceutical company MedImmune/Astrazeneca\, followed by a brief experience as a healthcare/pharmaceutical consultant. Her research interests and expertise lie in medical and pharmaceutical research and development\, particularly in the fields of nanobiotechnology\, bio-inspired materials\, downstream processing\, formulation and drug delivery. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-discussions-iris-batalha/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220513T100000
DTEND;TZID=Europe/Madrid:20220513T120000
DTSTAMP:20260403T192601
CREATED:20220503T130848Z
LAST-MODIFIED:20220503T130848Z
UID:91649-1652436000-1652443200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Iris Batalha
DESCRIPTION:Nanotherapeutics – ‘How we sometimes underestimate the influence of little things’\nIris L. Batalha\, Institute for Bioengineering of Catalonia (IBEC) \nDeaths caused by infections from antibiotic-resistant bacteria are expected to skyrocket over the next decades\, with a staggering 10 million deaths per year projected for 2050. Treating infections by intracellular pathogens\, such as M. tuberculosis\, is ‘a perfect storm’. The WHO revealed that while some 50 new antibiotics and 10 biologics are under development\, only half of those target WHO-priority pathogens and the majority have very limited benefits when compared to existing antibiotics. Reformulating existent drugs in nanocarriers may help achieving enhanced efficacy and safety while reducing dose frequency\, by providing temporal and localised control of drug exposure. In this talk\, I will present my work on the synthesis of dual-drug tunable nanoparticle-based antibiotics\, which showed increased bacterial killing efficacy in a zebrafish larval model of mycobacterial infection when compared to free drugs at the same concentration. In addition\, nanoparticles were able to efficiently penetrate mycobacterial cords and granulomatous lesions – shielded regions of difficult access by free drugs\, improving the therapeutic effect. \n\nIris Batalha is currently a Junior Leader Research Fellow at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona\, a Panel Tutor in Nanotherapeutics at the University of Cambridge Institute of Continuing Education\, a freelance Senior Innovation Consultant at Inspiralia (Spain and USA)\, a Co-founder\, Director and Editor-in-Chief of the non-profit organisation Women Ahead of Their Time (WATT)\, and a Research Associate at Peterhouse College. From 2017 to 2020\, she was a joint Research Associate at the Department of Engineering Nanoscience Centre and Department of Medicine Molecular Immunity Unit\, University of Cambridge. From 2014 to 2017\, she worked at the Department of Chemical Engineering and Biotechnology\, University of Cambridge\, and the biopharmaceutical company MedImmune/Astrazeneca\, followed by a brief experience as a healthcare/pharmaceutical consultant. Her research interests and expertise lie in medical and pharmaceutical research and development\, particularly in the fields of nanobiotechnology\, bio-inspired materials\, downstream processing\, formulation and drug delivery. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-discussions-iris-batalha-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220513T100000
DTEND;TZID=Europe/Madrid:20220513T120000
DTSTAMP:20260403T192601
CREATED:20220503T130848Z
LAST-MODIFIED:20220503T130848Z
UID:96597-1652436000-1652443200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Iris Batalha
DESCRIPTION:Nanotherapeutics – ‘How we sometimes underestimate the influence of little things’\nIris L. Batalha\, Institute for Bioengineering of Catalonia (IBEC) \nDeaths caused by infections from antibiotic-resistant bacteria are expected to skyrocket over the next decades\, with a staggering 10 million deaths per year projected for 2050. Treating infections by intracellular pathogens\, such as M. tuberculosis\, is ‘a perfect storm’. The WHO revealed that while some 50 new antibiotics and 10 biologics are under development\, only half of those target WHO-priority pathogens and the majority have very limited benefits when compared to existing antibiotics. Reformulating existent drugs in nanocarriers may help achieving enhanced efficacy and safety while reducing dose frequency\, by providing temporal and localised control of drug exposure. In this talk\, I will present my work on the synthesis of dual-drug tunable nanoparticle-based antibiotics\, which showed increased bacterial killing efficacy in a zebrafish larval model of mycobacterial infection when compared to free drugs at the same concentration. In addition\, nanoparticles were able to efficiently penetrate mycobacterial cords and granulomatous lesions – shielded regions of difficult access by free drugs\, improving the therapeutic effect. \n\nIris Batalha is currently a Junior Leader Research Fellow at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona\, a Panel Tutor in Nanotherapeutics at the University of Cambridge Institute of Continuing Education\, a freelance Senior Innovation Consultant at Inspiralia (Spain and USA)\, a Co-founder\, Director and Editor-in-Chief of the non-profit organisation Women Ahead of Their Time (WATT)\, and a Research Associate at Peterhouse College. From 2017 to 2020\, she was a joint Research Associate at the Department of Engineering Nanoscience Centre and Department of Medicine Molecular Immunity Unit\, University of Cambridge. From 2014 to 2017\, she worked at the Department of Chemical Engineering and Biotechnology\, University of Cambridge\, and the biopharmaceutical company MedImmune/Astrazeneca\, followed by a brief experience as a healthcare/pharmaceutical consultant. Her research interests and expertise lie in medical and pharmaceutical research and development\, particularly in the fields of nanobiotechnology\, bio-inspired materials\, downstream processing\, formulation and drug delivery. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-discussions-iris-batalha-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220527T100000
DTEND;TZID=Europe/Madrid:20220527T120000
DTSTAMP:20260403T192601
CREATED:20220503T132210Z
LAST-MODIFIED:20220503T132210Z
UID:91658-1653645600-1653652800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Srivatsava Viswanadha Venkata Naga Sai and Madhura Murar
DESCRIPTION:Mechanical characterization of murine pluripotency dissolution\nSrivatsava Viswanadha Venkata Naga Sai\, Cellular and Molecular Mechanobiology Group \nMouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal\, mESCs exit naïve state and become functionally mature\, acquiring differentiation competence. From a mechanical point of view\, the instruction for initiating ground state exit is the integrin mediated mechano-sensing of extra cellular matrix (ECM). Although laminin has been found to be the pivotal ECM ligand for pluripotency dissolution\, the down-stream mechano-responses accompanying its sensing\, their spatio-temporal evolution and\, their regulatory role in mESC maturation remain unclear. In this work\, we combine mechanical measurements\, functional characterization\, and live cell imaging to unravel the role of mESCs-ECM interactions during naïve state exit and pluripotency dissolution. We employ a Rex1::GFPd2 expressing mESC line to monitor naïve state exit in real time\, combined with a laminin-rich ECM environment. During naïve state exit\, we observe a progressive increase in cell-ECM interaction\, marked by an increase in traction forces\, growth of focal adhesions\, and the reorganization of the basal actin from a mesh-like network into an oriented filamentous morphology reminiscent of stress fibres. Furthermore\, inhibition of non-muscle myosin-II using blebbistatin significantly delayed naïve state exit\, suggesting a regulatory role of cell contractility in mESC maturation. We finally investigate the role of these changes in cell-ECM interactions in mediating nuclear mechanoresponses\, and their influence in mESC pluripotency dissolution. \n\n\nDual peptide-mediated design of polymeric nanoparticles: towards precision prostate cancer targeting\nMadhura Murar\, Nanoscopy for Nanomedicine Group \nA key bottleneck of current cancer treatments is the lack of selective targeting of cancer cells to reduce undesirable side-effects. Nanoparticles (NPs) allow for the design of ligand-coated materials that can fulfil this function but have not yet shown consistent clinical results to make the ‘magic bullet’ theory a paradigm. The inconsistencies may be due to a range of biological factors like differences in disease models or expression levels of target receptor(s). NP design parameters could play a key role in alleviating these inconsistencies and significantly influence the therapeutic efficacy. To further improve this efficacy\, multi-ligand targeting strategies have been proposed\, however\, they remain controversial as they involve an intricate interplay between multitude of factors such as choice of ligands\, their receptor binding affinities\, NP surface densities\, stoichiometric ratios etc.\, thereby calling for a thorough understanding of the impact of these properties to improve their targeting potential. \nWithin this context\, we employ two cell targeting peptides (WQP and GE11) having different binding affinities to PSMA and EGFR receptors\, which are known PCa biomarkers. We evaluate the effect of multivalency of low affinity WQP peptide over its monomeric form on PSMA targeting. We find that by increasing the valency of WQP on NP surface\, we observe a higher cellular uptake of WQP-NPs over the monomeric form\, attributing to a stronger avidity. Next\, we assess the effect of two conjugation strategies using the high affinity GE11 peptide and study their impact on EGFR targeting in a systematic manner. We observe that conjugating GE11 peptide to PLGA-PEG polymer prior to NP formulation (pre-conjugation) allows for a higher and more controlled GE11 content on NP surface than conjugating it to formulated PLGA-PEG NPs (post-conjugation)\, consequently leading to a higher cellular uptake. \nBased on these findings\, we report a synthetic strategy for dual peptide-NPs with systematically varied properties\, specifically surface valencies and ratios\, and establish their impact on selective targeting in a prostate cancer (PCa) model. First\, we study the impact of peptide valencies on NP surface of dual NPs in comparison to single peptide-NPs on the selective cellular uptake in different PCa cell lines. Once we establish optimal surface valency\, we check the effect of different surface peptide ratios on cellular uptake and determine the optimal ratio for enhanced targeting of only those cells over-expressing both receptors\, by the virtue of improved selectivity. Somewhat counterintuitively\, we observe an increase in tumor cell uptake of NPs with lower peptide density\, which can be attributed to improved surface distribution of the peptide\, allowing for an enhanced availability to react with target receptor. This increase in uptake is a result of the two peptides acting in co-operation\, as opposed to simply an additive effect. Our findings demonstrate that through refined design and well-characterized NP formulations\, dual-peptide targeted nanosystems hold potential to provide precise cancer treatments. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220527T100000
DTEND;TZID=Europe/Madrid:20220527T120000
DTSTAMP:20260403T192601
CREATED:20220503T132210Z
LAST-MODIFIED:20220503T132210Z
UID:91656-1653645600-1653652800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Srivatsava Viswanadha Venkata Naga Sai and Madhura Murar
DESCRIPTION:Mechanical characterization of murine pluripotency dissolution\nSrivatsava Viswanadha Venkata Naga Sai\, Cellular and Molecular Mechanobiology Group \nMouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal\, mESCs exit naïve state and become functionally mature\, acquiring differentiation competence. From a mechanical point of view\, the instruction for initiating ground state exit is the integrin mediated mechano-sensing of extra cellular matrix (ECM). Although laminin has been found to be the pivotal ECM ligand for pluripotency dissolution\, the down-stream mechano-responses accompanying its sensing\, their spatio-temporal evolution and\, their regulatory role in mESC maturation remain unclear. In this work\, we combine mechanical measurements\, functional characterization\, and live cell imaging to unravel the role of mESCs-ECM interactions during naïve state exit and pluripotency dissolution. We employ a Rex1::GFPd2 expressing mESC line to monitor naïve state exit in real time\, combined with a laminin-rich ECM environment. During naïve state exit\, we observe a progressive increase in cell-ECM interaction\, marked by an increase in traction forces\, growth of focal adhesions\, and the reorganization of the basal actin from a mesh-like network into an oriented filamentous morphology reminiscent of stress fibres. Furthermore\, inhibition of non-muscle myosin-II using blebbistatin significantly delayed naïve state exit\, suggesting a regulatory role of cell contractility in mESC maturation. We finally investigate the role of these changes in cell-ECM interactions in mediating nuclear mechanoresponses\, and their influence in mESC pluripotency dissolution. \n\n\nDual peptide-mediated design of polymeric nanoparticles: towards precision prostate cancer targeting\nMadhura Murar\, Nanoscopy for Nanomedicine Group \nA key bottleneck of current cancer treatments is the lack of selective targeting of cancer cells to reduce undesirable side-effects. Nanoparticles (NPs) allow for the design of ligand-coated materials that can fulfil this function but have not yet shown consistent clinical results to make the ‘magic bullet’ theory a paradigm. The inconsistencies may be due to a range of biological factors like differences in disease models or expression levels of target receptor(s). NP design parameters could play a key role in alleviating these inconsistencies and significantly influence the therapeutic efficacy. To further improve this efficacy\, multi-ligand targeting strategies have been proposed\, however\, they remain controversial as they involve an intricate interplay between multitude of factors such as choice of ligands\, their receptor binding affinities\, NP surface densities\, stoichiometric ratios etc.\, thereby calling for a thorough understanding of the impact of these properties to improve their targeting potential. \nWithin this context\, we employ two cell targeting peptides (WQP and GE11) having different binding affinities to PSMA and EGFR receptors\, which are known PCa biomarkers. We evaluate the effect of multivalency of low affinity WQP peptide over its monomeric form on PSMA targeting. We find that by increasing the valency of WQP on NP surface\, we observe a higher cellular uptake of WQP-NPs over the monomeric form\, attributing to a stronger avidity. Next\, we assess the effect of two conjugation strategies using the high affinity GE11 peptide and study their impact on EGFR targeting in a systematic manner. We observe that conjugating GE11 peptide to PLGA-PEG polymer prior to NP formulation (pre-conjugation) allows for a higher and more controlled GE11 content on NP surface than conjugating it to formulated PLGA-PEG NPs (post-conjugation)\, consequently leading to a higher cellular uptake. \nBased on these findings\, we report a synthetic strategy for dual peptide-NPs with systematically varied properties\, specifically surface valencies and ratios\, and establish their impact on selective targeting in a prostate cancer (PCa) model. First\, we study the impact of peptide valencies on NP surface of dual NPs in comparison to single peptide-NPs on the selective cellular uptake in different PCa cell lines. Once we establish optimal surface valency\, we check the effect of different surface peptide ratios on cellular uptake and determine the optimal ratio for enhanced targeting of only those cells over-expressing both receptors\, by the virtue of improved selectivity. Somewhat counterintuitively\, we observe an increase in tumor cell uptake of NPs with lower peptide density\, which can be attributed to improved surface distribution of the peptide\, allowing for an enhanced availability to react with target receptor. This increase in uptake is a result of the two peptides acting in co-operation\, as opposed to simply an additive effect. Our findings demonstrate that through refined design and well-characterized NP formulations\, dual-peptide targeted nanosystems hold potential to provide precise cancer treatments. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220527T100000
DTEND;TZID=Europe/Madrid:20220527T120000
DTSTAMP:20260403T192601
CREATED:20220503T132210Z
LAST-MODIFIED:20220503T132210Z
UID:96601-1653645600-1653652800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Srivatsava Viswanadha Venkata Naga Sai and Madhura Murar
DESCRIPTION:Mechanical characterization of murine pluripotency dissolution\nSrivatsava Viswanadha Venkata Naga Sai\, Cellular and Molecular Mechanobiology Group \nMouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal\, mESCs exit naïve state and become functionally mature\, acquiring differentiation competence. From a mechanical point of view\, the instruction for initiating ground state exit is the integrin mediated mechano-sensing of extra cellular matrix (ECM). Although laminin has been found to be the pivotal ECM ligand for pluripotency dissolution\, the down-stream mechano-responses accompanying its sensing\, their spatio-temporal evolution and\, their regulatory role in mESC maturation remain unclear. In this work\, we combine mechanical measurements\, functional characterization\, and live cell imaging to unravel the role of mESCs-ECM interactions during naïve state exit and pluripotency dissolution. We employ a Rex1::GFPd2 expressing mESC line to monitor naïve state exit in real time\, combined with a laminin-rich ECM environment. During naïve state exit\, we observe a progressive increase in cell-ECM interaction\, marked by an increase in traction forces\, growth of focal adhesions\, and the reorganization of the basal actin from a mesh-like network into an oriented filamentous morphology reminiscent of stress fibres. Furthermore\, inhibition of non-muscle myosin-II using blebbistatin significantly delayed naïve state exit\, suggesting a regulatory role of cell contractility in mESC maturation. We finally investigate the role of these changes in cell-ECM interactions in mediating nuclear mechanoresponses\, and their influence in mESC pluripotency dissolution. \n\n\nDual peptide-mediated design of polymeric nanoparticles: towards precision prostate cancer targeting\nMadhura Murar\, Nanoscopy for Nanomedicine Group \nA key bottleneck of current cancer treatments is the lack of selective targeting of cancer cells to reduce undesirable side-effects. Nanoparticles (NPs) allow for the design of ligand-coated materials that can fulfil this function but have not yet shown consistent clinical results to make the ‘magic bullet’ theory a paradigm. The inconsistencies may be due to a range of biological factors like differences in disease models or expression levels of target receptor(s). NP design parameters could play a key role in alleviating these inconsistencies and significantly influence the therapeutic efficacy. To further improve this efficacy\, multi-ligand targeting strategies have been proposed\, however\, they remain controversial as they involve an intricate interplay between multitude of factors such as choice of ligands\, their receptor binding affinities\, NP surface densities\, stoichiometric ratios etc.\, thereby calling for a thorough understanding of the impact of these properties to improve their targeting potential. \nWithin this context\, we employ two cell targeting peptides (WQP and GE11) having different binding affinities to PSMA and EGFR receptors\, which are known PCa biomarkers. We evaluate the effect of multivalency of low affinity WQP peptide over its monomeric form on PSMA targeting. We find that by increasing the valency of WQP on NP surface\, we observe a higher cellular uptake of WQP-NPs over the monomeric form\, attributing to a stronger avidity. Next\, we assess the effect of two conjugation strategies using the high affinity GE11 peptide and study their impact on EGFR targeting in a systematic manner. We observe that conjugating GE11 peptide to PLGA-PEG polymer prior to NP formulation (pre-conjugation) allows for a higher and more controlled GE11 content on NP surface than conjugating it to formulated PLGA-PEG NPs (post-conjugation)\, consequently leading to a higher cellular uptake. \nBased on these findings\, we report a synthetic strategy for dual peptide-NPs with systematically varied properties\, specifically surface valencies and ratios\, and establish their impact on selective targeting in a prostate cancer (PCa) model. First\, we study the impact of peptide valencies on NP surface of dual NPs in comparison to single peptide-NPs on the selective cellular uptake in different PCa cell lines. Once we establish optimal surface valency\, we check the effect of different surface peptide ratios on cellular uptake and determine the optimal ratio for enhanced targeting of only those cells over-expressing both receptors\, by the virtue of improved selectivity. Somewhat counterintuitively\, we observe an increase in tumor cell uptake of NPs with lower peptide density\, which can be attributed to improved surface distribution of the peptide\, allowing for an enhanced availability to react with target receptor. This increase in uptake is a result of the two peptides acting in co-operation\, as opposed to simply an additive effect. Our findings demonstrate that through refined design and well-characterized NP formulations\, dual-peptide targeted nanosystems hold potential to provide precise cancer treatments. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220607T150000
DTEND;TZID=Europe/Madrid:20220607T170000
DTSTAMP:20260403T192601
CREATED:20220513T065850Z
LAST-MODIFIED:20220513T065850Z
UID:96623-1654614000-1654621200@ibecbarcelona.eu
SUMMARY:Meet the editors: Christine Horejs and Kristy Hooper
DESCRIPTION:Come and meet the editors of Nature Reviews Bioengineering and The Company of Biologists: Christine Horejs and Kirsty Hooper. In this seminar we will hear about the latest updates in their journals and we will discuss the future of scholarly publishing and the open access models. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/meet-the-editors-christine-horejs-and-kristy-hooper-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220607T150000
DTEND;TZID=Europe/Madrid:20220607T170000
DTSTAMP:20260403T192601
CREATED:20220513T065850Z
LAST-MODIFIED:20220513T065850Z
UID:91743-1654614000-1654621200@ibecbarcelona.eu
SUMMARY:Meet the editors: Christine Horejs and Kristy Hooper
DESCRIPTION:Come and meet the editors of Nature Reviews Bioengineering and The Company of Biologists: Christine Horejs and Kirsty Hooper. In this seminar we will hear about the latest updates in their journals and we will discuss the future of scholarly publishing and the open access models. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/meet-the-editors-christine-horejs-and-kristy-hooper/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220607T150000
DTEND;TZID=Europe/Madrid:20220607T170000
DTSTAMP:20260403T192601
CREATED:20220513T065850Z
LAST-MODIFIED:20220513T065850Z
UID:96621-1654614000-1654621200@ibecbarcelona.eu
SUMMARY:Meet the editors: Christine Horejs and Kristy Hooper
DESCRIPTION:Come and meet the editors of Nature Reviews Bioengineering and The Company of Biologists: Christine Horejs and Kirsty Hooper. In this seminar we will hear about the latest updates in their journals and we will discuss the future of scholarly publishing and the open access models. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/meet-the-editors-christine-horejs-and-kristy-hooper-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T110000
DTEND;TZID=Europe/Madrid:20220610T130000
DTSTAMP:20260403T192601
CREATED:20220517T135357Z
LAST-MODIFIED:20220517T135357Z
UID:96625-1654858800-1654866000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gerard Rubí Sans
DESCRIPTION:Development of an in vitro three-dimensional colorectal cancer model using cell-derived extracellular matrices\nAuthor: Gerard Rubí Sans\nDirectors: Dra. Elisabet Engel López and Dr. Miguel Ángel Mateos Timoneda \nThis thesis defence will take place at “Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)” at 11AM. \nIf you wish to follow this defence online\, you can do it through Google Meet here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gerard-rubi-sans/
LOCATION:Careers at IBEC
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T110000
DTEND;TZID=Europe/Madrid:20220610T130000
DTSTAMP:20260403T192601
CREATED:20220517T135357Z
LAST-MODIFIED:20220517T135357Z
UID:96630-1654858800-1654866000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gerard Rubí Sans
DESCRIPTION:Development of an in vitro three-dimensional colorectal cancer model using cell-derived extracellular matrices\nAuthor: Gerard Rubí Sans\nDirectors: Dra. Elisabet Engel López and Dr. Miguel Ángel Mateos Timoneda \nThis thesis defence will take place at “Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)” at 11AM. \nIf you wish to follow this defence online\, you can do it through Google Meet here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gerard-rubi-sans-3/
LOCATION:Careers at IBEC
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T110000
DTEND;TZID=Europe/Madrid:20220610T130000
DTSTAMP:20260403T192601
CREATED:20220517T135357Z
LAST-MODIFIED:20220517T135357Z
UID:96628-1654858800-1654866000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gerard Rubí Sans
DESCRIPTION:Development of an in vitro three-dimensional colorectal cancer model using cell-derived extracellular matrices\nAuthor: Gerard Rubí Sans\nDirectors: Dra. Elisabet Engel López and Dr. Miguel Ángel Mateos Timoneda \nThis thesis defence will take place at “Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)” at 11AM. \nIf you wish to follow this defence online\, you can do it through Google Meet here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gerard-rubi-sans-2/
LOCATION:Careers at IBEC
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220617T083000
DTEND;TZID=Europe/Madrid:20220619T140000
DTSTAMP:20260403T192601
CREATED:20211025T144511Z
LAST-MODIFIED:20220614T182638Z
UID:88045-1655454600-1655647200@ibecbarcelona.eu
SUMMARY:EMBL-IBEC Winter Conference Engineering Multicellular Systems
DESCRIPTION:EMBL and IBEC aim to contribute to the discussion on challenges and opportunities in the expanding field of engineered multicellular systems\n \nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos. \nThis biennial series of will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \nThe 2nd edition conference will take place in PRBB Auditorium (Barcelona Biomedical Research Park)\, in Barcelona from 9-11th February 2022. We expect to bring together 150 researchers including stem cell biologists\, systems biologists\, physicists and engineers. \nIMPORTANT DEADLINES\n\nAbstract submission deadline: 15/11/2021\nNotification of acceptance: 30/11/2021\nEarly registration: 30/12/2021\nLate registration: 30/01/2022 \nAbstract submission here \nRegistration here \n#EIWC22
URL:https://ibecbarcelona.eu/event/embl-ibec-winter-conference-engineering-multicellular-systems/
LOCATION:Barcelona Biomedical Research Park (PRBB)\, Dr. Aiguader 88 \, Barcelona\, 08003
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T100000
DTEND;TZID=Europe/Madrid:20220627T140000
DTSTAMP:20260403T192601
CREATED:20220623T110756Z
LAST-MODIFIED:20220623T110756Z
UID:96636-1656324000-1656338400@ibecbarcelona.eu
SUMMARY:Biomedical signal interpretation and smartphone sensors for the assessment of trunk function and sleep disorders in patients with spinal cord injury
DESCRIPTION:Author: Yolanda del Castillo\nGroup: Biomedical Signal Processing and Interpretation\nDirectors: Raimon Jané \n  \nAbstract:\nSpinal cord injury (SCI) is one of the leading causes of disability worldwide. SCI causes motor and sensory impairment below the level of the injury\, but it is also associated with many other health complications. Two of these problems are trunk muscle impairment and sleep disorders. Impaired trunk function affects postural control and sitting balance\, which are critical for activities of daily living. Disturbed sleep causes fatigue and sleepiness and can lead to serious comorbidities\, impacting patient recovery and outcomes. However\, due to the multiple health problems secondary to SCI and the limitations in current diagnostic tools\, trunk function and sleep are rarely examined after SCI. The non-invasive acquisition and analysis of biomedical signals can help to overcome this issue\, providing quantitative measures to assess patient condition. Smartphones can facilitate this task\, thanks to their ubiquitous presence and powerful sensors.\n\n\nThe aim of this PhD thesis is to propose new smartphone-based tools and biomedical signal analysis techniques for the quantitative assessment of trunk function and sleep-disordered breathing (SDB) in patients with SCI.  This thesis is divided into two parts\, including four publications in high-impact journals. The first part addresses the characterization of trunk function in healthy subjects and patients with cervical (cSCI) and thoracic SCI (tSCI). The second part focuses on the development of a mobile health (mHealth) system based on smartphone audio signals for obstructive sleep apnea (OSA) diagnosis\, and the detection and monitoring of SDB in SCI patients.\n\nThe first part of the thesis introduces a novel methodology to quantitatively evaluate trunk function by combining electromyography (EMG) and smartphone accelerometry. In the first study\, we characterized the muscle activity and movement patterns of trunk flexion during reaching in healthy humans and investigated if trunk stability was affected by a startling acoustic stimulus (SAS). We found that SAS markedly reduced the response time (RespT) and EMG onset latencies of all muscles (the so-called StartReact effect)\, either prime movers or stabilizers. In the second study\, we evaluated trunk function and the effects of a SAS in patients with cSCI and tSCI. The results revealed deficits in postural control and compensatory strategies employed by SCI patients\, such as delayed responses and high lateral deviations\, with potential consequences for rehabilitation. This was the first study investigating the StartReact responses in trunk muscles in SCI. The SAS significantly shortened the RespT in tSCI\, but not in cSCI\, which suggests an increased cortical control in cSCI.\n\nIn the second part of the thesis\, we present mHealth tools for monitoring sleep disorders and investigate the sleep patterns of SCI patients. In the first article of this part\, we designed a smartphone system and novel algorithms based on acoustic analysis for OSA screening. This approach demonstrated good agreement with a commercial system for home OSA diagnosis\, correctly detecting and stratifying all the OSA patients. In the last article\, sleep studies were performed in SCI patients using the smartphone\, showing a very high prevalence of moderate-to-severe SDB in SCI patients. This study highlighted the problem of SDB in SCI and provided simple cost-effective tools to improve the detection and management of SDB in SCI patients.\nOverall\, this thesis supports the use of smartphones and biomedical signal analysis for the assessment of trunk function and SDB in SCI patients. These novel approaches provide quantitative and objective measures for the evaluation and follow-up of patients in a simple and non-invasive way. We also give insights into the underlying mechanisms of postural control\, respiratory function during sleep\, and the changes occurring after SCI. Consequently\, our results open the way for improving the management of health complications associated with SCI or other disabling conditions. \n\n\n\n\n\nThis thesis defence will take place at: Sala d’Actes de l’Escola d’Enginyeria Barcelona Est (EEBE)\, Edifici A\, planta 0\, Campus Diagonal-Besòs de la UPC\, Av. d’Eduard Maristany\, 16\, 08019 Barcelona. \nIf you wish to follow this defence online\, you can do it through this link: meet.google.com/roe-omfr-sse
URL:https://ibecbarcelona.eu/event/biomedical-signal-interpretation-and-smartphone-sensors-for-the-assessment-of-trunk-function-and-sleep-disorders-in-patients-with-spinal-cord-injury/
LOCATION:Sala d’Actes EEBE\, Edifici A\,\, Av. Eduard Maristany 16\, 08019 Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T100000
DTEND;TZID=Europe/Madrid:20220627T140000
DTSTAMP:20260403T192601
CREATED:20220623T110756Z
LAST-MODIFIED:20220623T110756Z
UID:96631-1656324000-1656338400@ibecbarcelona.eu
SUMMARY:Biomedical signal interpretation and smartphone sensors for the assessment of trunk function and sleep disorders in patients with spinal cord injury
DESCRIPTION:Author: Yolanda Castillo\nGroup: Biomedical Signal Processing and Interpretation\nDirectors: Raimon Jané \n  \nAbstract:\nSpinal cord injury (SCI) is one of the leading causes of disability worldwide. SCI causes motor and sensory impairment below the level of the injury\, but it is also associated with many other health complications. Two of these problems are trunk muscle impairment and sleep disorders. Impaired trunk function affects postural control and sitting balance\, which are critical for activities of daily living. Disturbed sleep causes fatigue and sleepiness and can lead to serious comorbidities\, impacting patient recovery and outcomes. However\, due to the multiple health problems secondary to SCI and the limitations in current diagnostic tools\, trunk function and sleep are rarely examined after SCI. The non-invasive acquisition and analysis of biomedical signals can help to overcome this issue\, providing quantitative measures to assess patient condition. Smartphones can facilitate this task\, thanks to their ubiquitous presence and powerful sensors.\n\n\nThe aim of this PhD thesis is to propose new smartphone-based tools and biomedical signal analysis techniques for the quantitative assessment of trunk function and sleep-disordered breathing (SDB) in patients with SCI.  This thesis is divided into two parts\, including four publications in high-impact journals. The first part addresses the characterization of trunk function in healthy subjects and patients with cervical (cSCI) and thoracic SCI (tSCI). The second part focuses on the development of a mobile health (mHealth) system based on smartphone audio signals for obstructive sleep apnea (OSA) diagnosis\, and the detection and monitoring of SDB in SCI patients.\n\nThe first part of the thesis introduces a novel methodology to quantitatively evaluate trunk function by combining electromyography (EMG) and smartphone accelerometry. In the first study\, we characterized the muscle activity and movement patterns of trunk flexion during reaching in healthy humans and investigated if trunk stability was affected by a startling acoustic stimulus (SAS). We found that SAS markedly reduced the response time (RespT) and EMG onset latencies of all muscles (the so-called StartReact effect)\, either prime movers or stabilizers. In the second study\, we evaluated trunk function and the effects of a SAS in patients with cSCI and tSCI. The results revealed deficits in postural control and compensatory strategies employed by SCI patients\, such as delayed responses and high lateral deviations\, with potential consequences for rehabilitation. This was the first study investigating the StartReact responses in trunk muscles in SCI. The SAS significantly shortened the RespT in tSCI\, but not in cSCI\, which suggests an increased cortical control in cSCI.\n\nIn the second part of the thesis\, we present mHealth tools for monitoring sleep disorders and investigate the sleep patterns of SCI patients. In the first article of this part\, we designed a smartphone system and novel algorithms based on acoustic analysis for OSA screening. This approach demonstrated good agreement with a commercial system for home OSA diagnosis\, correctly detecting and stratifying all the OSA patients. In the last article\, sleep studies were performed in SCI patients using the smartphone\, showing a very high prevalence of moderate-to-severe SDB in SCI patients. This study highlighted the problem of SDB in SCI and provided simple cost-effective tools to improve the detection and management of SDB in SCI patients.\n\nOverall\, this thesis supports the use of smartphones and biomedical signal analysis for the assessment of trunk function and SDB in SCI patients. These novel approaches provide quantitative and objective measures for the evaluation and follow-up of patients in a simple and non-invasive way. We also give insights into the underlying mechanisms of postural control\, respiratory function during sleep\, and the changes occurring after SCI. Consequently\, our results open the way for improving the management of health complications associated with SCI or other disabling conditions.\n\n\n\n\n\nThis thesis defence will take place at: Sala d’Actes de l’Escola d’Enginyeria Barcelona Est (EEBE)\, Edifici A\, planta 0\, Campus Diagonal-Besòs de la UPC\, Av. d’Eduard Maristany\, 16\, 08019 Barcelona. \nIf you wish to follow this defence online\, you can do it through this link: meet.google.com/roe-omfr-sse
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-yolanda-castillo
LOCATION:Sala d’Actes EEBE\, Edifici A\,\, Av. Eduard Maristany 16\, 08019 Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T123000
DTEND;TZID=Europe/Madrid:20220627T133000
DTSTAMP:20260403T192601
CREATED:20220627T070730Z
LAST-MODIFIED:20220627T070730Z
UID:96639-1656333000-1656336600@ibecbarcelona.eu
SUMMARY:Last minute Seminar: Laura Suter-Dick
DESCRIPTION:Liver and Kidney: 3D-in vitro systems for disease modelling and biomarker discovery\nProf. Laura Suter-Dick\nFHNW University of Applied Sciences and Arts Northwestern Switzerland School of Life Sciences\, Institute for Chemistry and Bioanalytics a Basel.
URL:https://ibecbarcelona.eu/event/last-minute-seminar-laura-suter-dick/
LOCATION:Sala Baobab\, Tower I - 11th floor
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR