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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180328T100000
DTEND;TZID=Europe/Madrid:20180328T110000
DTSTAMP:20260424T180004
CREATED:20180322T115517Z
LAST-MODIFIED:20180322T115517Z
UID:58142-1522231200-1522234800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurélien Bancaud
DESCRIPTION:µLAS technology for DNA processing: setting up elementary functions (concentration\, separation\, purification\, identification) and application in oncology and targeted sequencing\nAurélien Bancaud\, LAAS-CNRS\, Toulouse\, France\nWe recently developed the µLAS technology for nucleic acids processing. Its operating principle relies on the monitoring of DNA transport in a viscoelastic liquid under the combined action of hydrodynamic and electrophoretic forces (1). DNA molecules are dragged toward the walls of microchannels by a transverse force proportional to their contour length. Because the hydrodynamic decreases near the wall\, DNA molecules are sorted according to their molecular weight. Furthermore\, by tailoring the geometry of a channel with a constriction\, we can tune the amplitude of transverse forces and stop molecules to design a concentrator that achieves enrichment rates of 100 to 1000 fold per minute. \nWe will derive a quantitative model of DNA transport in µLAS that relies on 1 fitting parameter and perform rational optimizations of the technology. We will then exploit µLAS for sizing cell-free circulating DNA (cfDNA) in the blood (2)\, and demonstrate that cfDNA profiling is a promissing biomarker for the follow-up of cancer patients. Finally\, we will present the principle of a DNA size-selective valve for the purification and sequencing of target genomic regions by combining µLAS with Cas9 endonuclease. \n(1) Ranchon et al.\, Lab Chip (2016)\n (2) Andriamanampisoa et al.\, Anal Chem (2018)
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurelien-bancaud/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180328T100000
DTEND;TZID=Europe/Madrid:20180328T110000
DTSTAMP:20260424T180004
CREATED:20180322T115517Z
LAST-MODIFIED:20180322T115517Z
UID:96199-1522231200-1522234800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurélien Bancaud
DESCRIPTION:µLAS technology for DNA processing: setting up elementary functions (concentration\, separation\, purification\, identification) and application in oncology and targeted sequencing\nAurélien Bancaud\, LAAS-CNRS\, Toulouse\, France\nWe recently developed the µLAS technology for nucleic acids processing. Its operating principle relies on the monitoring of DNA transport in a viscoelastic liquid under the combined action of hydrodynamic and electrophoretic forces (1). DNA molecules are dragged toward the walls of microchannels by a transverse force proportional to their contour length. Because the hydrodynamic decreases near the wall\, DNA molecules are sorted according to their molecular weight. Furthermore\, by tailoring the geometry of a channel with a constriction\, we can tune the amplitude of transverse forces and stop molecules to design a concentrator that achieves enrichment rates of 100 to 1000 fold per minute. \nWe will derive a quantitative model of DNA transport in µLAS that relies on 1 fitting parameter and perform rational optimizations of the technology. We will then exploit µLAS for sizing cell-free circulating DNA (cfDNA) in the blood (2)\, and demonstrate that cfDNA profiling is a promissing biomarker for the follow-up of cancer patients. Finally\, we will present the principle of a DNA size-selective valve for the purification and sequencing of target genomic regions by combining µLAS with Cas9 endonuclease. \n(1) Ranchon et al.\, Lab Chip (2016)\n (2) Andriamanampisoa et al.\, Anal Chem (2018)
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurelien-bancaud-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180323T100000
DTEND;TZID=Europe/Madrid:20180323T110000
DTSTAMP:20260424T180004
CREATED:20180312T102003Z
LAST-MODIFIED:20180312T102128Z
UID:57989-1521799200-1521802800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Andreu Matamoros and Maider Badiola
DESCRIPTION:Role of the Cellular Prion Protein in hippocampal neurotransmission\, learning and memory\nAndreu Matamoros\, Molecular and cellular neurobiotechnology\nMisfoldedCellular Prion protein (PrPC) was described as the causative agent of the transmissible spongiform encephalopathies (TSEs)\, independently of its origin (sporadic\, iatrogenic or genetic). PrPC is present at the synaptic terminal\, especially in the cerebral cortex including the hippocampus. It is involved in numerous cellular processes: cell proliferation and differentiation\, copper homeostasis and cell signaling\, among others. Recently has been demonstrated that most of these functions are based in misinterpretation of the mice models and need to be reevaluated. On the other hand\, PrPC protein levels are decreased in TSEs. This opened a new insight in the study of TSEs: understanding the pathology not just as a gain of function due to the prion aggregation\, but as a loss of function due to the reduction of PrPC. \nOur goal is to elucidate the role of PrPC in hippocampal circuitry and its derived functions (i.e. learning and memory) using a new PrPC knockout mice (ZH3). Spontaneous firing and network formation are monitored with Calcium imaging in hippocampus primary cultures. Object Recognition Test and Skinner’s Test are performed to evaluate memory and learning in ZH3 mice. LTP and evocated potentials are also measured in CA3-CA1 connection in vivo. Glutamate neurotransmission is evaluated behaviourally and electrophysiologycally using kainate administration. Finally\, mRNA from ZH3 mice hippocampus has been sequenced to identify differential gene expression compared to Wt mice. \nDissecting the role of PrPC in hippocampus neurotransmission will allow us to better understand alterations in the brain of TSEs patients. \n  \nPaving the way towards an in-vitro 3D mechanosensory-motor circuit on a chip\nMaider Badiola\, Nanobioengineering\nNeuromuscular diseases (NMD) are neurological disorders affecting muscles and their control through nervous system. They often involve afferent and efferent pathways of the Peripheral Nervous System\, and their effects might be reflected in the mechanosensory-motor circuit at different cellular levels (including sensory and motor neurons\, glia and muscle dysfunctions)\, and in the connexion among them. \nThe aim of this research is to create an in-vitro model to mimic the 3D microenvironment of a neural circuit for locomotion to understand and find treatments for NMDs. To that end\, organ-on-a-chip technologies are used for the integration of sensorial and motor neural components together with a functional muscular unit. \nFor that purpose\, we first fabricated a compartmentalised microfluidic device in PDMS using soft lithography techniques. Then the afferent and efferent pathways of the Peripheral Nervous System were mimicked in 2D culturing primary neurons involved in the locomotion circuit (motoneurons and dorsal root ganglia) with Schwann cells in the microdevice. \nBut 2D cultures offer many limitations compared to 3D\, and the assessment of the afferent pathway separately often means a complication. Optogenetics technique can be used in skeletal muscle to induce contraction\, mimicking a natural innervation to some length and facilitating the study of the afferent pathway separately. Therefore\, we propose a study model where primary spinal motor- or dorsal root ganglia sensory- neurons are cultured in 3D in different compartments together with optogenetically sensitive myocytes (a channelrhodopsin-2 positive cell line). This could make possible to evaluate the functionality of efferent and afferent pathways separately. \nThis study provides the basis for future steps towards NMD in-vitro study models.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-andreu-matamoros-and-maider-badiola/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180323T100000
DTEND;TZID=Europe/Madrid:20180323T110000
DTSTAMP:20260424T180004
CREATED:20180312T102003Z
LAST-MODIFIED:20180312T102003Z
UID:96187-1521799200-1521802800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Andreu Matamoros and Maider Badiola
DESCRIPTION:Role of the Cellular Prion Protein in hippocampal neurotransmission\, learning and memory\nAndreu Matamoros\, Molecular and cellular neurobiotechnology\nMisfoldedCellular Prion protein (PrPC) was described as the causative agent of the transmissible spongiform encephalopathies (TSEs)\, independently of its origin (sporadic\, iatrogenic or genetic). PrPC is present at the synaptic terminal\, especially in the cerebral cortex including the hippocampus. It is involved in numerous cellular processes: cell proliferation and differentiation\, copper homeostasis and cell signaling\, among others. Recently has been demonstrated that most of these functions are based in misinterpretation of the mice models and need to be reevaluated. On the other hand\, PrPC protein levels are decreased in TSEs. This opened a new insight in the study of TSEs: understanding the pathology not just as a gain of function due to the prion aggregation\, but as a loss of function due to the reduction of PrPC. \nOur goal is to elucidate the role of PrPC in hippocampal circuitry and its derived functions (i.e. learning and memory) using a new PrPC knockout mice (ZH3). Spontaneous firing and network formation are monitored with Calcium imaging in hippocampus primary cultures. Object Recognition Test and Skinner’s Test are performed to evaluate memory and learning in ZH3 mice. LTP and evocated potentials are also measured in CA3-CA1 connection in vivo. Glutamate neurotransmission is evaluated behaviourally and electrophysiologycally using kainate administration. Finally\, mRNA from ZH3 mice hippocampus has been sequenced to identify differential gene expression compared to Wt mice. \nDissecting the role of PrPC in hippocampus neurotransmission will allow us to better understand alterations in the brain of TSEs patients. \n  \nPaving the way towards an in-vitro 3D mechanosensory-motor circuit on a chip\nMaider Badiola\, Nanobioengineering\nNeuromuscular diseases (NMD) are neurological disorders affecting muscles and their control through nervous system. They often involve afferent and efferent pathways of the Peripheral Nervous System\, and their effects might be reflected in the mechanosensory-motor circuit at different cellular levels (including sensory and motor neurons\, glia and muscle dysfunctions)\, and in the connexion among them. \nThe aim of this research is to create an in-vitro model to mimic the 3D microenvironment of a neural circuit for locomotion to understand and find treatments for NMDs. To that end\, organ-on-a-chip technologies are used for the integration of sensorial and motor neural components together with a functional muscular unit. \nFor that purpose\, we first fabricated a compartmentalised microfluidic device in PDMS using soft lithography techniques. Then the afferent and efferent pathways of the Peripheral Nervous System were mimicked in 2D culturing primary neurons involved in the locomotion circuit (motoneurons and dorsal root ganglia) with Schwann cells in the microdevice. \nBut 2D cultures offer many limitations compared to 3D\, and the assessment of the afferent pathway separately often means a complication. Optogenetics technique can be used in skeletal muscle to induce contraction\, mimicking a natural innervation to some length and facilitating the study of the afferent pathway separately. Therefore\, we propose a study model where primary spinal motor- or dorsal root ganglia sensory- neurons are cultured in 3D in different compartments together with optogenetically sensitive myocytes (a channelrhodopsin-2 positive cell line). This could make possible to evaluate the functionality of efferent and afferent pathways separately. \nThis study provides the basis for future steps towards NMD in-vitro study models.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-andreu-matamoros-and-maider-badiola-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180323T100000
DTEND;TZID=Europe/Madrid:20180323T110000
DTSTAMP:20260424T180004
CREATED:20180312T102003Z
LAST-MODIFIED:20180312T102003Z
UID:96188-1521799200-1521802800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Andreu Matamoros and Maider Badiola
DESCRIPTION:Role of the Cellular Prion Protein in hippocampal neurotransmission\, learning and memory\nAndreu Matamoros\, Molecular and cellular neurobiotechnology\nMisfoldedCellular Prion protein (PrPC) was described as the causative agent of the transmissible spongiform encephalopathies (TSEs)\, independently of its origin (sporadic\, iatrogenic or genetic). PrPC is present at the synaptic terminal\, especially in the cerebral cortex including the hippocampus. It is involved in numerous cellular processes: cell proliferation and differentiation\, copper homeostasis and cell signaling\, among others. Recently has been demonstrated that most of these functions are based in misinterpretation of the mice models and need to be reevaluated. On the other hand\, PrPC protein levels are decreased in TSEs. This opened a new insight in the study of TSEs: understanding the pathology not just as a gain of function due to the prion aggregation\, but as a loss of function due to the reduction of PrPC. \nOur goal is to elucidate the role of PrPC in hippocampal circuitry and its derived functions (i.e. learning and memory) using a new PrPC knockout mice (ZH3). Spontaneous firing and network formation are monitored with Calcium imaging in hippocampus primary cultures. Object Recognition Test and Skinner’s Test are performed to evaluate memory and learning in ZH3 mice. LTP and evocated potentials are also measured in CA3-CA1 connection in vivo. Glutamate neurotransmission is evaluated behaviourally and electrophysiologycally using kainate administration. Finally\, mRNA from ZH3 mice hippocampus has been sequenced to identify differential gene expression compared to Wt mice. \nDissecting the role of PrPC in hippocampus neurotransmission will allow us to better understand alterations in the brain of TSEs patients. \n  \nPaving the way towards an in-vitro 3D mechanosensory-motor circuit on a chip\nMaider Badiola\, Nanobioengineering\nNeuromuscular diseases (NMD) are neurological disorders affecting muscles and their control through nervous system. They often involve afferent and efferent pathways of the Peripheral Nervous System\, and their effects might be reflected in the mechanosensory-motor circuit at different cellular levels (including sensory and motor neurons\, glia and muscle dysfunctions)\, and in the connexion among them. \nThe aim of this research is to create an in-vitro model to mimic the 3D microenvironment of a neural circuit for locomotion to understand and find treatments for NMDs. To that end\, organ-on-a-chip technologies are used for the integration of sensorial and motor neural components together with a functional muscular unit. \nFor that purpose\, we first fabricated a compartmentalised microfluidic device in PDMS using soft lithography techniques. Then the afferent and efferent pathways of the Peripheral Nervous System were mimicked in 2D culturing primary neurons involved in the locomotion circuit (motoneurons and dorsal root ganglia) with Schwann cells in the microdevice. \nBut 2D cultures offer many limitations compared to 3D\, and the assessment of the afferent pathway separately often means a complication. Optogenetics technique can be used in skeletal muscle to induce contraction\, mimicking a natural innervation to some length and facilitating the study of the afferent pathway separately. Therefore\, we propose a study model where primary spinal motor- or dorsal root ganglia sensory- neurons are cultured in 3D in different compartments together with optogenetically sensitive myocytes (a channelrhodopsin-2 positive cell line). This could make possible to evaluate the functionality of efferent and afferent pathways separately. \nThis study provides the basis for future steps towards NMD in-vitro study models.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-andreu-matamoros-and-maider-badiola-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180323T100000
DTEND;TZID=Europe/Madrid:20180323T110000
DTSTAMP:20260424T180004
CREATED:20180312T102003Z
LAST-MODIFIED:20180312T102003Z
UID:96189-1521799200-1521802800@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Andreu Matamoros and Maider Badiola
DESCRIPTION:Role of the Cellular Prion Protein in hippocampal neurotransmission\, learning and memory\nAndreu Matamoros\, Molecular and cellular neurobiotechnology\nMisfoldedCellular Prion protein (PrPC) was described as the causative agent of the transmissible spongiform encephalopathies (TSEs)\, independently of its origin (sporadic\, iatrogenic or genetic). PrPC is present at the synaptic terminal\, especially in the cerebral cortex including the hippocampus. It is involved in numerous cellular processes: cell proliferation and differentiation\, copper homeostasis and cell signaling\, among others. Recently has been demonstrated that most of these functions are based in misinterpretation of the mice models and need to be reevaluated. On the other hand\, PrPC protein levels are decreased in TSEs. This opened a new insight in the study of TSEs: understanding the pathology not just as a gain of function due to the prion aggregation\, but as a loss of function due to the reduction of PrPC. \nOur goal is to elucidate the role of PrPC in hippocampal circuitry and its derived functions (i.e. learning and memory) using a new PrPC knockout mice (ZH3). Spontaneous firing and network formation are monitored with Calcium imaging in hippocampus primary cultures. Object Recognition Test and Skinner’s Test are performed to evaluate memory and learning in ZH3 mice. LTP and evocated potentials are also measured in CA3-CA1 connection in vivo. Glutamate neurotransmission is evaluated behaviourally and electrophysiologycally using kainate administration. Finally\, mRNA from ZH3 mice hippocampus has been sequenced to identify differential gene expression compared to Wt mice. \nDissecting the role of PrPC in hippocampus neurotransmission will allow us to better understand alterations in the brain of TSEs patients. \n  \nPaving the way towards an in-vitro 3D mechanosensory-motor circuit on a chip\nMaider Badiola\, Nanobioengineering\nNeuromuscular diseases (NMD) are neurological disorders affecting muscles and their control through nervous system. They often involve afferent and efferent pathways of the Peripheral Nervous System\, and their effects might be reflected in the mechanosensory-motor circuit at different cellular levels (including sensory and motor neurons\, glia and muscle dysfunctions)\, and in the connexion among them. \nThe aim of this research is to create an in-vitro model to mimic the 3D microenvironment of a neural circuit for locomotion to understand and find treatments for NMDs. To that end\, organ-on-a-chip technologies are used for the integration of sensorial and motor neural components together with a functional muscular unit. \nFor that purpose\, we first fabricated a compartmentalised microfluidic device in PDMS using soft lithography techniques. Then the afferent and efferent pathways of the Peripheral Nervous System were mimicked in 2D culturing primary neurons involved in the locomotion circuit (motoneurons and dorsal root ganglia) with Schwann cells in the microdevice. \nBut 2D cultures offer many limitations compared to 3D\, and the assessment of the afferent pathway separately often means a complication. Optogenetics technique can be used in skeletal muscle to induce contraction\, mimicking a natural innervation to some length and facilitating the study of the afferent pathway separately. Therefore\, we propose a study model where primary spinal motor- or dorsal root ganglia sensory- neurons are cultured in 3D in different compartments together with optogenetically sensitive myocytes (a channelrhodopsin-2 positive cell line). This could make possible to evaluate the functionality of efferent and afferent pathways separately. \nThis study provides the basis for future steps towards NMD in-vitro study models.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-andreu-matamoros-and-maider-badiola-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260424T180004
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:57987-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260424T180004
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:96186-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260424T180004
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:96190-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260424T180004
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:96191-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180317T110000
DTEND;TZID=Europe/Madrid:20180317T170000
DTSTAMP:20260424T180004
CREATED:20180221T102312Z
LAST-MODIFIED:20180221T102312Z
UID:96175-1521284400-1521306000@ibecbarcelona.eu
SUMMARY:IBEC Students calçotada!
DESCRIPTION:Calçotada 2018 (PDF)
URL:https://ibecbarcelona.eu/event/ibec-students-calcotada-2/
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180317T110000
DTEND;TZID=Europe/Madrid:20180317T170000
DTSTAMP:20260424T180004
CREATED:20180221T102312Z
LAST-MODIFIED:20180221T102312Z
UID:96176-1521284400-1521306000@ibecbarcelona.eu
SUMMARY:IBEC Students calçotada!
DESCRIPTION:Calçotada 2018 (PDF)
URL:https://ibecbarcelona.eu/event/ibec-students-calcotada-3/
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180317T110000
DTEND;TZID=Europe/Madrid:20180317T170000
DTSTAMP:20260424T180004
CREATED:20180221T102312Z
LAST-MODIFIED:20180221T102312Z
UID:57819-1521284400-1521306000@ibecbarcelona.eu
SUMMARY:IBEC Students calçotada!
DESCRIPTION:Calçotada 2018 (PDF)
URL:https://ibecbarcelona.eu/event/ibec-students-calcotada/
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180317T110000
DTEND;TZID=Europe/Madrid:20180317T170000
DTSTAMP:20260424T180004
CREATED:20180221T102312Z
LAST-MODIFIED:20180221T102312Z
UID:96177-1521284400-1521306000@ibecbarcelona.eu
SUMMARY:IBEC Students calçotada!
DESCRIPTION:Calçotada 2018 (PDF)
URL:https://ibecbarcelona.eu/event/ibec-students-calcotada-4/
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180316T110000
DTEND;TZID=Europe/Madrid:20180316T130000
DTSTAMP:20260424T180004
CREATED:20180315T101159Z
LAST-MODIFIED:20180315T101159Z
UID:58081-1521198000-1521205200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Laura Urrea
DESCRIPTION:Funciones de la proteína priónica celular\, a-sinucleína y Reelina en enfermedades neurodegenerativas\nLaura Urrea\, Molecular and cellular neurobiotechnology  group\nLaura will be defending her PhD thesis this Friday 16th March at 11h in the Aula de Graus\, Faculty of Biology\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-laura-urrea/
LOCATION:Aula de Graus\, Faculty of Biology\, Diagonal\, 643\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180316T110000
DTEND;TZID=Europe/Madrid:20180316T130000
DTSTAMP:20260424T180004
CREATED:20180315T101159Z
LAST-MODIFIED:20180315T101159Z
UID:96192-1521198000-1521205200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Laura Urrea
DESCRIPTION:Funciones de la proteína priónica celular\, a-sinucleína y Reelina en enfermedades neurodegenerativas\nLaura Urrea\, Molecular and cellular neurobiotechnology  group\nLaura will be defending her PhD thesis this Friday 16th March at 11h in the Aula de Graus\, Faculty of Biology\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-laura-urrea-2/
LOCATION:Aula de Graus\, Faculty of Biology\, Diagonal\, 643\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180316T110000
DTEND;TZID=Europe/Madrid:20180316T130000
DTSTAMP:20260424T180004
CREATED:20180315T101159Z
LAST-MODIFIED:20180315T101159Z
UID:96197-1521198000-1521205200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Laura Urrea
DESCRIPTION:Funciones de la proteína priónica celular\, a-sinucleína y Reelina en enfermedades neurodegenerativas\nLaura Urrea\, Molecular and cellular neurobiotechnology  group\nLaura will be defending her PhD thesis this Friday 16th March at 11h in the Aula de Graus\, Faculty of Biology\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-laura-urrea-3/
LOCATION:Aula de Graus\, Faculty of Biology\, Diagonal\, 643\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180316T110000
DTEND;TZID=Europe/Madrid:20180316T130000
DTSTAMP:20260424T180004
CREATED:20180315T101159Z
LAST-MODIFIED:20180315T101159Z
UID:96198-1521198000-1521205200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Laura Urrea
DESCRIPTION:Funciones de la proteína priónica celular\, a-sinucleína y Reelina en enfermedades neurodegenerativas\nLaura Urrea\, Molecular and cellular neurobiotechnology  group\nLaura will be defending her PhD thesis this Friday 16th March at 11h in the Aula de Graus\, Faculty of Biology\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-laura-urrea-4/
LOCATION:Aula de Graus\, Faculty of Biology\, Diagonal\, 643\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180307T110000
DTEND;TZID=Europe/Madrid:20180307T130000
DTSTAMP:20260424T180004
CREATED:20180214T085043Z
LAST-MODIFIED:20180214T085043Z
UID:96170-1520420400-1520427600@ibecbarcelona.eu
SUMMARY:Mitigating bias: promoting diversity and sustainable excellence in research
DESCRIPTION:Joint seminar organized by the IRB Barcelona and IBEC Equality and Diversity Committee\nClaartje Vinkenburg\, VU University Amsterdam\nClaartje Vinkenburg\, PhD\, is associate professor of organizational behaviour  and independent expert consultant. Dr Vinkenburg’s research activities\, partly funded by the European Research Council\, deal with gender and ethnic diversity in professional and academic careers as well as with sustainability in combining career and care.  \nThis 2-hour seminar aims to explore and explain the concept\, causes and consequences of implicit or unconscious bias and how it affects careers\, workplace culture\, and work-family reconciliation in research organizations. In addition\, ways to effectively promote diversity and inclusion in research by learning how to mitigate bias in the scientific career progression will be addressed. \nOpen to all IBEC members and IRB Barcelona. \nIf you’d like to attend\, please send an email to hr@ibecbarcelona.eu before 15:00h on February 23th (Remember to put your supervisor in CC).
URL:https://ibecbarcelona.eu/event/mitigating-bias-promoting-diversity-and-sustainable-excellence-in-research-3/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180307T110000
DTEND;TZID=Europe/Madrid:20180307T130000
DTSTAMP:20260424T180004
CREATED:20180214T085043Z
LAST-MODIFIED:20180214T085043Z
UID:57731-1520420400-1520427600@ibecbarcelona.eu
SUMMARY:Mitigating bias: promoting diversity and sustainable excellence in research
DESCRIPTION:Joint seminar organized by the IRB Barcelona and IBEC Equality and Diversity Committee\nClaartje Vinkenburg\, VU University Amsterdam\nClaartje Vinkenburg\, PhD\, is associate professor of organizational behaviour  and independent expert consultant. Dr Vinkenburg’s research activities\, partly funded by the European Research Council\, deal with gender and ethnic diversity in professional and academic careers as well as with sustainability in combining career and care.  \nThis 2-hour seminar aims to explore and explain the concept\, causes and consequences of implicit or unconscious bias and how it affects careers\, workplace culture\, and work-family reconciliation in research organizations. In addition\, ways to effectively promote diversity and inclusion in research by learning how to mitigate bias in the scientific career progression will be addressed. \nOpen to all IBEC members and IRB Barcelona. \nIf you’d like to attend\, please send an email to hr@ibecbarcelona.eu before 15:00h on February 23th (Remember to put your supervisor in CC).
URL:https://ibecbarcelona.eu/event/mitigating-bias-promoting-diversity-and-sustainable-excellence-in-research/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180307T110000
DTEND;TZID=Europe/Madrid:20180307T130000
DTSTAMP:20260424T180004
CREATED:20180214T085043Z
LAST-MODIFIED:20180214T085043Z
UID:96171-1520420400-1520427600@ibecbarcelona.eu
SUMMARY:Mitigating bias: promoting diversity and sustainable excellence in research
DESCRIPTION:Joint seminar organized by the IRB Barcelona and IBEC Equality and Diversity Committee\nClaartje Vinkenburg\, VU University Amsterdam\nClaartje Vinkenburg\, PhD\, is associate professor of organizational behaviour  and independent expert consultant. Dr Vinkenburg’s research activities\, partly funded by the European Research Council\, deal with gender and ethnic diversity in professional and academic careers as well as with sustainability in combining career and care.  \nThis 2-hour seminar aims to explore and explain the concept\, causes and consequences of implicit or unconscious bias and how it affects careers\, workplace culture\, and work-family reconciliation in research organizations. In addition\, ways to effectively promote diversity and inclusion in research by learning how to mitigate bias in the scientific career progression will be addressed. \nOpen to all IBEC members and IRB Barcelona. \nIf you’d like to attend\, please send an email to hr@ibecbarcelona.eu before 15:00h on February 23th (Remember to put your supervisor in CC).
URL:https://ibecbarcelona.eu/event/mitigating-bias-promoting-diversity-and-sustainable-excellence-in-research-4/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180307T110000
DTEND;TZID=Europe/Madrid:20180307T130000
DTSTAMP:20260424T180004
CREATED:20180214T085043Z
LAST-MODIFIED:20180214T085043Z
UID:96169-1520420400-1520427600@ibecbarcelona.eu
SUMMARY:Mitigating bias: promoting diversity and sustainable excellence in research
DESCRIPTION:Joint seminar organized by the IRB Barcelona and IBEC Equality and Diversity Committee\nClaartje Vinkenburg\, VU University Amsterdam\nClaartje Vinkenburg\, PhD\, is associate professor of organizational behaviour  and independent expert consultant. Dr Vinkenburg’s research activities\, partly funded by the European Research Council\, deal with gender and ethnic diversity in professional and academic careers as well as with sustainability in combining career and care.  \nThis 2-hour seminar aims to explore and explain the concept\, causes and consequences of implicit or unconscious bias and how it affects careers\, workplace culture\, and work-family reconciliation in research organizations. In addition\, ways to effectively promote diversity and inclusion in research by learning how to mitigate bias in the scientific career progression will be addressed. \nOpen to all IBEC members and IRB Barcelona. \nIf you’d like to attend\, please send an email to hr@ibecbarcelona.eu before 15:00h on February 23th (Remember to put your supervisor in CC).
URL:https://ibecbarcelona.eu/event/mitigating-bias-promoting-diversity-and-sustainable-excellence-in-research-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180306T110000
DTEND;TZID=Europe/Madrid:20180306T130000
DTSTAMP:20260424T180004
CREATED:20180305T090004Z
LAST-MODIFIED:20180305T090004Z
UID:96195-1520334000-1520341200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Sergio Oller
DESCRIPTION:“Data processing for Life Sciences Measurements with Gas Chromatography – Ion Mobility Spectrometry”\nSergio Oller\, Signal and Information Processing for Sensing Systems group\nSergi will be defending his PhD thesis this Tuesday 6th March at 11h in the Sala Eduard Fontserè\, Faculty of Physics\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-sergio-oller-3/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180306T110000
DTEND;TZID=Europe/Madrid:20180306T130000
DTSTAMP:20260424T180004
CREATED:20180305T090004Z
LAST-MODIFIED:20180305T090004Z
UID:96182-1520334000-1520341200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Sergio Oller
DESCRIPTION:“Data processing for Life Sciences Measurements with Gas Chromatography – Ion Mobility Spectrometry”\nSergio Oller\, Signal and Information Processing for Sensing Systems group\nSergi will be defending his PhD thesis this Tuesday 6th March at 11h in the Sala Eduard Fontserè\, Faculty of Physics\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-sergio-oller-2/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180306T110000
DTEND;TZID=Europe/Madrid:20180306T130000
DTSTAMP:20260424T180004
CREATED:20180305T090004Z
LAST-MODIFIED:20180305T090004Z
UID:96196-1520334000-1520341200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Sergio Oller
DESCRIPTION:“Data processing for Life Sciences Measurements with Gas Chromatography – Ion Mobility Spectrometry”\nSergio Oller\, Signal and Information Processing for Sensing Systems group\nSergi will be defending his PhD thesis this Tuesday 6th March at 11h in the Sala Eduard Fontserè\, Faculty of Physics\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-sergio-oller-4/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180306T110000
DTEND;TZID=Europe/Madrid:20180306T130000
DTSTAMP:20260424T180004
CREATED:20180305T090004Z
LAST-MODIFIED:20180305T093914Z
UID:57880-1520334000-1520341200@ibecbarcelona.eu
SUMMARY:IBEC PhD thesis defence: Sergio Oller
DESCRIPTION:“Data processing for Life Sciences Measurements with Gas Chromatography – Ion Mobility Spectrometry”\nSergio Oller\, Signal and Information Processing for Sensing Systems group\nSergi will be defending his PhD thesis this Tuesday 6th March at 11h in the Sala Eduard Fontserè\, Faculty of Physics\, UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-phd-thesis-defence-sergio-oller/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180228T100000
DTEND;TZID=Europe/Madrid:20180228T110000
DTSTAMP:20260424T180004
CREATED:20180201T164138Z
LAST-MODIFIED:20180201T164138Z
UID:96164-1519812000-1519815600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Johanna Ivaska
DESCRIPTION:Mechanosensitive regulation of cancer and pluripotency\nJohanna Ivaska\, Turku Centre for Biotechnology\, University of Turku\, Finland\nTissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions\, in conjunction with the actin cytoskeleton\, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer\, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However\, the mechanisms how stromal ECM regulates cancer progression is not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. Reprogramming and survival of human pluripotent stem cells is heavily influenced by their adhesion to the underlying ECM. We have recently investigated the link between ECM-adhesion\, the actin cytoskeleton and cell contractility in maintenance of pluripotency. I will describe our recent efforts to define the stem-cell adhesion structure in nanoscale and how it contributes to maintenance of pluripotency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-johanna-ivaska-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180228T100000
DTEND;TZID=Europe/Madrid:20180228T110000
DTSTAMP:20260424T180004
CREATED:20180201T164138Z
LAST-MODIFIED:20180201T164138Z
UID:96165-1519812000-1519815600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Johanna Ivaska
DESCRIPTION:Mechanosensitive regulation of cancer and pluripotency\nJohanna Ivaska\, Turku Centre for Biotechnology\, University of Turku\, Finland\nTissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions\, in conjunction with the actin cytoskeleton\, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer\, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However\, the mechanisms how stromal ECM regulates cancer progression is not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. Reprogramming and survival of human pluripotent stem cells is heavily influenced by their adhesion to the underlying ECM. We have recently investigated the link between ECM-adhesion\, the actin cytoskeleton and cell contractility in maintenance of pluripotency. I will describe our recent efforts to define the stem-cell adhesion structure in nanoscale and how it contributes to maintenance of pluripotency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-johanna-ivaska-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180228T100000
DTEND;TZID=Europe/Madrid:20180228T110000
DTSTAMP:20260424T180004
CREATED:20180201T164138Z
LAST-MODIFIED:20180201T164148Z
UID:57497-1519812000-1519815600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Johanna Ivaska
DESCRIPTION:Mechanosensitive regulation of cancer and pluripotency\nJohanna Ivaska\, Turku Centre for Biotechnology\, University of Turku\, Finland\nTissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions\, in conjunction with the actin cytoskeleton\, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer\, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However\, the mechanisms how stromal ECM regulates cancer progression is not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. Reprogramming and survival of human pluripotent stem cells is heavily influenced by their adhesion to the underlying ECM. We have recently investigated the link between ECM-adhesion\, the actin cytoskeleton and cell contractility in maintenance of pluripotency. I will describe our recent efforts to define the stem-cell adhesion structure in nanoscale and how it contributes to maintenance of pluripotency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-johanna-ivaska/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180228T100000
DTEND;TZID=Europe/Madrid:20180228T110000
DTSTAMP:20260424T180004
CREATED:20180201T164138Z
LAST-MODIFIED:20180201T164138Z
UID:96163-1519812000-1519815600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Johanna Ivaska
DESCRIPTION:Mechanosensitive regulation of cancer and pluripotency\nJohanna Ivaska\, Turku Centre for Biotechnology\, University of Turku\, Finland\nTissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions\, in conjunction with the actin cytoskeleton\, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer\, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However\, the mechanisms how stromal ECM regulates cancer progression is not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. Reprogramming and survival of human pluripotent stem cells is heavily influenced by their adhesion to the underlying ECM. We have recently investigated the link between ECM-adhesion\, the actin cytoskeleton and cell contractility in maintenance of pluripotency. I will describe our recent efforts to define the stem-cell adhesion structure in nanoscale and how it contributes to maintenance of pluripotency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-johanna-ivaska-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR