Institute for Bioengineering of Catalonia

Visita/Taller ESTALMAT
2019-04-16 10:00 - 13:30 (Europe/Madrid) | PCB
La cèl·lula
Visita-taller per conèixer els conceptes bàsics de la cèl·lula i introducció al concepte d’ADN i de bioenginyeria
En el taller de la cèl·lula farem un repàs als conceptes bàsics de la cèl·lula: què és una cèl·lula, on trobem les cèl·lules, les parts de la cèl·lula i les diferències bàsiques entre cèl·lula animal i cèl·lula vegetal.
En aquesta activitat s’introdueix el concepte d’ADN: què és, on es troba i quina funció fa, així com unes petites pinzellades sobre les bases de la manipulació genètica (bioenginyeria) que es fa a l’IBEC.
Els alumnes podran observar les seves pròpies cèl·lules al microscopi i analitzaran les diferències entre cèl·lula animal i vegetal. Acabarem el taller amb una visita als laboratoris.
ESTALMAT és un projecte de la Reial Acadèmia de Ciències Exactes, Físiques i Naturals
Tracta de detectar, orientar i estimular de manera continuada, al llarg de dos cursos, el talent matemàtic excepcional d’estudiants de 12-13 anys, sense desarrelar-los del seu entorn, mitjançant una orientació setmanal, que s’efectúa cada setmana durant tres hores.

Visita Erasmus-Mundus
2019-04-24 09:35 - 23:30, 2019-04-25 09:35 - 23:30 | IBEC, floor 11, Tower I, Baldiri Reixac 4-8, 08028 Barcelona, Spain
Visita estudiantes del Màster de Nanociències i Nanotecnologia de la UB a través del programa Erasmus Mundus.
9:35 h – Bienvenida y presentació del IBEC
10:00 h – Visita al laboratorio del grupo “Targeted therapeutics and nanodevices” PI: Prof. Silvia Muro
10:30 h – Visita al laboratirio del grupo “Smart nano-bio-devices” PI: Prof. Samuel Sánchez
11:00 h – Visita al laboratirio del grupo “Nanobioengineering” PI: Prof. Josep Samitier

Una nueva ruta de acceso al cerebro
2019-04-25 00:00 - 14:00 | Centre Cívic Josep M. Trias i Peitx., Riera Blanca, 1, Barcelona, Spain
Conferencia a cargo de la Dra. Sílvia Muro, profesora ICREA y líder de grupo en el Instituto de Bioingeniería de Cataluña (IBEC).
La barrera hematoencefálica es un sistema de células que mantiene al cerebro protegido ante las sustancias nocivas. Esta barrera, que actúa como agente protector, también supone un impedimento para que lleguen al cerebro la mayoría de los fármacos, dificultando el tratamiento de las afecciones neurológicas como el párkinson.
Existen fármacos empleados en la enfermedad de Gaucher, la cual tiene algunas características comunes al párkinson, que no pasan al cerebro y que por tanto, no pueden ser probados para tratar esta patología. Por este motivo, es necesario diseñar agentes terapéuticos que sean capaces de atravesar la barrera hematoencefálica.
Durante la conferencia, la Dra. Silvia Muro nos explicará el proyecto que está desarrollando en el IBEC, donde ha identificado un nuevo mecanismo de transporte que consigue atravesar la barrera hematoencefálica permitiendo el paso de fármacos al cerebro, esto abriría una vía para tratar el Parkinson utilizando algunos fármacos ya existentes y que actualmente se aplican a otras patologías.
Plazas limitadas, confirma tu asistencia a info@catparkinson.org o llamando al teléfono 93 245 43 96

PhD Thesis Defence: Andreu Matamoros
2019-04-25 11:00 - 13:00 | Unnamed Venue, Diagonal, 643, Barcelona, Spain
Noves funcions de PrPC en neurotransmissió, neuroprotecció i neurodegeneració
Andreu Matamoros Angles, Molecular and Cellular Neurobiotechnology group
Andreu Matamoros be defending her PhD thesis on Thursday 25th April at 11:00 in the Aula de Graus of the Facultat de Biologia (UB).
Everybody is welcome to attend.
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If you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar, please contact ibeccommunications@ibecbarcelona.eu

PhD Thesis Defence: Andreu Matamoros
2019-04-25 11:00 - 13:00 | Aula de Graus, Faculty of Biology, Diagonal, 643, Barcelona, Spain

PhD Thesis Defence: Andreu Matamoros
2019-04-25 11:00 - 13:00 | Unnamed Venue, Diagonal, 643, Barcelona, Spain
Noves funcions de PrPC en neurotransmissió, neuroprotecció i neurodegeneració
Andreu Matamoros Angles, Molecular and Cellular Neurobiotechnology group
Andreu Matamoros will be defending his PhD thesis on Thursday 25th April at 11:00 in the Aula de Graus of the Facultat de Biologia (UB).
Everybody is welcome to attend.
—
If you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar, please contact ibeccommunications@ibecbarcelona.eu

PhD Discussions Sessions: Andrés Marco and Davia Prischich
2019-04-26 10:00 - 12:00 | IBEC, floor 11, Tower I, Baldiri Reixac 4-8, 08028 Barcelona, Spain
An iCRISPR Platform for Human Functional Genetics in Human Pluripotent Stem Cells (hPSCs)
Andrés Marco, Pluripotency for organ regeneration
Self-renewal and pluripotency are the two major functional properties defining human pluripotent stem cells (hPSCs), allowing them to be cultured indefinitely in a dish and maintaining their capacity to differentiate to virtually any human cell lineage, tissue or organ. Hence, they represent an ideal model for studying cellular and multicellular behaviors in both physiological and pathological conditions.
Up until recently, the genome of hPSCs was difficult to manipulate, limiting considerably their use for functional genetics. To solve this problem, here we present the results of our ongoing effort to engineer an iCRISPR platform for highly efficient genome engineering in hPSCs. We have targeted the safe harbor AAVS1 locus using an inducible Cas9 editing vector (iC2), an inducible dCas9 activator (iCa) or an inducible dCas9 repressor (iCr). iCRISPR allows inducible gene knockout, gene upregulation and gene repression.
All together, these lines will greatly expand the repertoire of applications that can be addressed with hPSCs. Our final goal is to use the iCRISPR platform to dissect kidney development and disease in hPSC-derived kidney organoids.
Traffic Lights peptides to photocontrol clathrin-mediated endocytosis in yeasts
Davia Prischich, Nanoprobes and nanoswitches
Clathrin-mediated endocytosis (CME) is crucial to all eukaryotic cells. It is implicated in a variety of cellular processes that range from nutrient uptake, signal transduction and regulation of the membrane components including surface proteins. The functioning of this transient machinery requires a complex network of proteins that cannot be untangled only by means of genetic modification and immunological depletion. In this sense, photopharmacology provides a powerful aid by complementing the selectivity of drugs with the remote and reversible control offered by light.
Traffic Lights (TLs) peptides are cell-permeable, photoswitchable inhibitors specifically developed to target the main adaptor complex of the CME machinery. These peptides, named TL1 and TL2, have already proved capable of inhibiting CME in a light-regulated manner when tested in mammalian cells. Here we show that TL peptides retain their activity in yeast. After having confirmed photoregulation of CME events in this extremely versatile eukaryotic model system, we now aim to achieve in situ activation of the peptide so to directly address the role of endocytosis in cellular processes such as cytokinesis or cell migration.

Visita STEAM a les aules
2019-04-29 15:00 - 18:00 | IBEC, floor 11, Tower I, Baldiri Reixac 4-8, 08028 Barcelona, Spain
L’objectiu del programa és el foment dels coneixements, les competències i les
vocacions científiques entre els i les estudiants de 1r i 2n d’ESO d’una manera
experimental i aplicant una metodologia científica.
El programa STEAM a les aules vol fer les disciplines STEAM (Science, Technology,
Art, Engineering and Mathematics) accessibles a tothom, nois i noies, ampliant la
perspectiva de gènere i desmitificant la figura de la persona científica, lligada a un
perfil i estatus socioeconòmic. Per aconseguir aquest objectiu s’utilitza la figura del
doctorand/a com a eix vertebrador.

Visita STEM a les aules
2019-05-02 09:00 - 12:00 | IBEC, floor 11, Tower I, Baldiri Reixac 4-8, 08028 Barcelona, Spain

Tailored Nanopatterning Scaffolds for Musculoskeletal Tissue Regeneration (1st Annual Meeting)
2019-05-10 09:30 - 15:00 | IBEC, floor 11, Tower I, Baldiri Reixac 4-8, 08028 Barcelona, Spain
Tailored Nanopatterning Scaffolds for Musculoskeletal Tissue Regeneration (1st Annual Meeting)
Organized by: Josep Samitier and Anna Lagunas
Musculoskeletal conditions are the second largest contributor to disability worldwide with an estimated US$30 billion spent annually on their management in the USA alone. The limited regenerative capacity of many of the tissues from the musculoskeletal system fostered the research on alternatives to the common surgical procedures, including stem cell therapies. For that, the development of preconditioning methods is mandatory to ensure an efficient implantation and overall success. Since nanometric environmental inputs are a paramount factor influencing cell behavior, including stem cell migration and differentiation, stem cell-based tissue engineering strategies are increasingly including nanoscale considerations when designing cell environments to better mimic native homeostatic conditions and drive cells towards development of the desired tissue. Within the framework of the Intramural collaboration of CIBER BBN “Tailored Nanopatterning Scaffolds for Musculoskeletal Tissue Regeneration”, the members of the consortium meet in Barcelona at IBEC presenting their contributions to the topic.

09:30-10:00
Welcome. Josep Samitier, Institut de Bioenginyeria de Catalunya (IBEC)-Networking Biomedical Research Center (CIBER).

10:00-10:30
Nanopatterning defines tissue organization and intercellular communication network architecture in mesenchymal condensation. Anna Lagunas, Networking Biomedical Research Center (CIBER)-Institut de Bioenginyeria de Catalunya (IBEC).

10:30-11:00
New dendrimeric materials for biological applications. Yolanda Vida, Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga – IBIMA.

11:00-11:30
Molecular characterization of genes involved in cell-to-cell communication during the chondrogenic differentiation of human mesenchymal stromal cell. Cristina Rodríguez. Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC).

11:30-12:00
Coffee Break

12:00-12:30
Mechanical characterization of elastomers. José Luis Gómez Ribelles. Biomaterials Center of the Universidad Politécnica de Valencia (CBM-UPV)-Networking Biomedical Research Center (CIBER).

12:30-13:00
In vitro tenogenic differentiation of MSCs and in vivo models of tendon repair. Leonor Santos. Networking Biomedical Research Center (CIBER)-Tissue Regeneration and Bioengineering Laboratory, University of Málaga (LABRET-UMA).

13:00-14:00
Lunch

14:00-15:30
Discussion
