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DTSTART;TZID=Europe/Madrid:20200228T100000
DTEND;TZID=Europe/Madrid:20200228T120000
DTSTAMP:20260403T224657
CREATED:20200221T110843Z
LAST-MODIFIED:20200221T110843Z
UID:96629-1582884000-1582891200@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Xarxa Quiroga and Adrián López
DESCRIPTION:Biochemical responses to cell membrane mechanical remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology\nIn a range of physiological processes\, from extravasation to endocytosis\, cells are constantly submitted to morphological changes\, which eventually entail plasma membrane reshaping and adaptation. This remodelling could be harnessed by cells to detect and respond to shape changes\, enabling mechanosensing mechanisms. However\, how this occurs is still largely unknown.\nTo increase our understanding on how such process can happen\, we have engineered a cell-stretching system that allows us to induce controlled plasma membrane remodelling while monitoring the whole process with the help of a microscope.\nBy using this set up\, we have found that cell de-stretch triggers the formation of transient membrane evaginations whose resorption is actively regulated by BAR protein recruitment and actin polymerisation. The described process may be the first part of a molecular cascade used by cells in response to stretch. \n\nDevelopment of Microphysiological Systems for the Evaluation of Regenerative Therapies\nAdrián López\, Biomaterials for Regenerative Therapies\nThe modelling of human organs has long been a task for scientist in order to lower the costs of therapeutic development and understand the pathological onset of human disease. Animal models remain the gold standard for drug discovery\, despite their widely recognized limitations such as their marked differences with humans in terms of genetics and etiology or their high cost. \nDuring the last decade\, the advancements in tissue engineering and microfabrication gave rise to innovative models known as organs-on-a-chip or microphysiological systems\, which aim to build functional miniaturized tissues in vitro that closely mimic the actual in vivo microenvironment. In this work\, we will present two microphysiological platforms that we are developing with the goal of understanding and evaluating biomaterial-based regenerative therapies. The first model is aimed at replicating the bone healing microenvironment to evaluate the angiogenic potential of calcium-releasing scaffolds. The second model will be focused on the generation of an ischemic injury on a physiologically relevant cardiac tissue to test if lactate-releasing scaffolds are able to stimulate cardiac tissue regeneration.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-xarxa-quiroga-and-adrian-lopez-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200228T100000
DTEND;TZID=Europe/Madrid:20200228T120000
DTSTAMP:20260403T224657
CREATED:20200221T110843Z
LAST-MODIFIED:20200221T110843Z
UID:71615-1582884000-1582891200@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Xarxa Quiroga and Adrián López
DESCRIPTION:Biochemical responses to cell membrane mechanical remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology\nIn a range of physiological processes\, from extravasation to endocytosis\, cells are constantly submitted to morphological changes\, which eventually entail plasma membrane reshaping and adaptation. This remodelling could be harnessed by cells to detect and respond to shape changes\, enabling mechanosensing mechanisms. However\, how this occurs is still largely unknown.\nTo increase our understanding on how such process can happen\, we have engineered a cell-stretching system that allows us to induce controlled plasma membrane remodelling while monitoring the whole process with the help of a microscope.\nBy using this set up\, we have found that cell de-stretch triggers the formation of transient membrane evaginations whose resorption is actively regulated by BAR protein recruitment and actin polymerisation. The described process may be the first part of a molecular cascade used by cells in response to stretch. \n\nDevelopment of Microphysiological Systems for the Evaluation of Regenerative Therapies\nAdrián López\, Biomaterials for Regenerative Therapies\nThe modelling of human organs has long been a task for scientist in order to lower the costs of therapeutic development and understand the pathological onset of human disease. Animal models remain the gold standard for drug discovery\, despite their widely recognized limitations such as their marked differences with humans in terms of genetics and etiology or their high cost. \nDuring the last decade\, the advancements in tissue engineering and microfabrication gave rise to innovative models known as organs-on-a-chip or microphysiological systems\, which aim to build functional miniaturized tissues in vitro that closely mimic the actual in vivo microenvironment. In this work\, we will present two microphysiological platforms that we are developing with the goal of understanding and evaluating biomaterial-based regenerative therapies. The first model is aimed at replicating the bone healing microenvironment to evaluate the angiogenic potential of calcium-releasing scaffolds. The second model will be focused on the generation of an ischemic injury on a physiologically relevant cardiac tissue to test if lactate-releasing scaffolds are able to stimulate cardiac tissue regeneration.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-xarxa-quiroga-and-adrian-lopez/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200228T100000
DTEND;TZID=Europe/Madrid:20200228T120000
DTSTAMP:20260403T224657
CREATED:20200221T110843Z
LAST-MODIFIED:20200221T110843Z
UID:96627-1582884000-1582891200@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Xarxa Quiroga and Adrián López
DESCRIPTION:Biochemical responses to cell membrane mechanical remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology\nIn a range of physiological processes\, from extravasation to endocytosis\, cells are constantly submitted to morphological changes\, which eventually entail plasma membrane reshaping and adaptation. This remodelling could be harnessed by cells to detect and respond to shape changes\, enabling mechanosensing mechanisms. However\, how this occurs is still largely unknown.\nTo increase our understanding on how such process can happen\, we have engineered a cell-stretching system that allows us to induce controlled plasma membrane remodelling while monitoring the whole process with the help of a microscope.\nBy using this set up\, we have found that cell de-stretch triggers the formation of transient membrane evaginations whose resorption is actively regulated by BAR protein recruitment and actin polymerisation. The described process may be the first part of a molecular cascade used by cells in response to stretch. \n\nDevelopment of Microphysiological Systems for the Evaluation of Regenerative Therapies\nAdrián López\, Biomaterials for Regenerative Therapies\nThe modelling of human organs has long been a task for scientist in order to lower the costs of therapeutic development and understand the pathological onset of human disease. Animal models remain the gold standard for drug discovery\, despite their widely recognized limitations such as their marked differences with humans in terms of genetics and etiology or their high cost. \nDuring the last decade\, the advancements in tissue engineering and microfabrication gave rise to innovative models known as organs-on-a-chip or microphysiological systems\, which aim to build functional miniaturized tissues in vitro that closely mimic the actual in vivo microenvironment. In this work\, we will present two microphysiological platforms that we are developing with the goal of understanding and evaluating biomaterial-based regenerative therapies. The first model is aimed at replicating the bone healing microenvironment to evaluate the angiogenic potential of calcium-releasing scaffolds. The second model will be focused on the generation of an ischemic injury on a physiologically relevant cardiac tissue to test if lactate-releasing scaffolds are able to stimulate cardiac tissue regeneration.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-xarxa-quiroga-and-adrian-lopez-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200228T100000
DTEND;TZID=Europe/Madrid:20200228T120000
DTSTAMP:20260403T224657
CREATED:20200221T110843Z
LAST-MODIFIED:20200221T110843Z
UID:96632-1582884000-1582891200@ibecbarcelona.eu
SUMMARY:PhD Discussions Sessions: Xarxa Quiroga and Adrián López
DESCRIPTION:Biochemical responses to cell membrane mechanical remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology\nIn a range of physiological processes\, from extravasation to endocytosis\, cells are constantly submitted to morphological changes\, which eventually entail plasma membrane reshaping and adaptation. This remodelling could be harnessed by cells to detect and respond to shape changes\, enabling mechanosensing mechanisms. However\, how this occurs is still largely unknown.\nTo increase our understanding on how such process can happen\, we have engineered a cell-stretching system that allows us to induce controlled plasma membrane remodelling while monitoring the whole process with the help of a microscope.\nBy using this set up\, we have found that cell de-stretch triggers the formation of transient membrane evaginations whose resorption is actively regulated by BAR protein recruitment and actin polymerisation. The described process may be the first part of a molecular cascade used by cells in response to stretch. \n\nDevelopment of Microphysiological Systems for the Evaluation of Regenerative Therapies\nAdrián López\, Biomaterials for Regenerative Therapies\nThe modelling of human organs has long been a task for scientist in order to lower the costs of therapeutic development and understand the pathological onset of human disease. Animal models remain the gold standard for drug discovery\, despite their widely recognized limitations such as their marked differences with humans in terms of genetics and etiology or their high cost. \nDuring the last decade\, the advancements in tissue engineering and microfabrication gave rise to innovative models known as organs-on-a-chip or microphysiological systems\, which aim to build functional miniaturized tissues in vitro that closely mimic the actual in vivo microenvironment. In this work\, we will present two microphysiological platforms that we are developing with the goal of understanding and evaluating biomaterial-based regenerative therapies. The first model is aimed at replicating the bone healing microenvironment to evaluate the angiogenic potential of calcium-releasing scaffolds. The second model will be focused on the generation of an ischemic injury on a physiologically relevant cardiac tissue to test if lactate-releasing scaffolds are able to stimulate cardiac tissue regeneration.
URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-xarxa-quiroga-and-adrian-lopez-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200227T110000
DTEND;TZID=Europe/Madrid:20200227T130000
DTSTAMP:20260403T224657
CREATED:20200218T121211Z
LAST-MODIFIED:20200220T082610Z
UID:71495-1582801200-1582808400@ibecbarcelona.eu
SUMMARY:NANO Rare Disease Day 2020
DESCRIPTION:Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina para el tratamiento y diagnóstico de dichas enfermedades\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapia\nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \nInscripciones abiertas \n 
URL:https://ibecbarcelona.eu/event/nano-rare-diseade-day-2020/
LOCATION:Auditori J. Plaza\, Hospital Sant Joan de Déu\, Passeig de Sant Joan de Déu\, 2\, Esplugues de Llobregat\, Barcelona\, 08950 \, Spain
CATEGORIES:External symposium / conference / congress
ATTACH;FMTTYPE=image/png:https://ibecbarcelona.eu/wp-content/uploads/2020/02/rarediseasesday_banner-0x0-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200227T110000
DTEND;TZID=Europe/Madrid:20200227T130000
DTSTAMP:20260403T224657
CREATED:20200218T121211Z
LAST-MODIFIED:20200218T121211Z
UID:96624-1582801200-1582808400@ibecbarcelona.eu
SUMMARY:NANO Rare Disease Day 2020
DESCRIPTION:Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina para el tratamiento y diagnóstico de dichas enfermedades\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapias\nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \nInscripciones abiertas \n 
URL:https://ibecbarcelona.eu/event/nano-rare-diseade-day-2020-3/
LOCATION:Auditori J. Plaza\, Hospital Sant Joan de Déu\, Passeig de Sant Joan de Déu\, 2\, Esplugues de Llobregat\, Barcelona\, 08950 \, Spain
CATEGORIES:External symposium / conference / congress
ATTACH;FMTTYPE=image/png:https://ibecbarcelona.eu/wp-content/uploads/2020/02/rarediseasesday_banner-0x0-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200227T110000
DTEND;TZID=Europe/Madrid:20200227T130000
DTSTAMP:20260403T224657
CREATED:20200218T121211Z
LAST-MODIFIED:20200218T121211Z
UID:96622-1582801200-1582808400@ibecbarcelona.eu
SUMMARY:NANO Rare Disease Day 2020
DESCRIPTION:Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina para el tratamiento y diagnóstico de dichas enfermedades\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapias\nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \nInscripciones abiertas \n 
URL:https://ibecbarcelona.eu/event/nano-rare-diseade-day-2020-2/
LOCATION:Auditori J. Plaza\, Hospital Sant Joan de Déu\, Passeig de Sant Joan de Déu\, 2\, Esplugues de Llobregat\, Barcelona\, 08950 \, Spain
CATEGORIES:External symposium / conference / congress
ATTACH;FMTTYPE=image/png:https://ibecbarcelona.eu/wp-content/uploads/2020/02/rarediseasesday_banner-0x0-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200227T110000
DTEND;TZID=Europe/Madrid:20200227T130000
DTSTAMP:20260403T224657
CREATED:20200218T121211Z
LAST-MODIFIED:20200218T121211Z
UID:96626-1582801200-1582808400@ibecbarcelona.eu
SUMMARY:NANO Rare Disease Day 2020
DESCRIPTION:Nano Rare Diseases Day es un evento organizado en el marco del Día Mundial de las Enfermedades Minoritarias donde se darán a conocer las últimas innovaciones en materia de Nanomedicina para el tratamiento y diagnóstico de dichas enfermedades\, con temas que van desde el diagnóstico precoz\, la liberación controlada de fármacos o el desarrollo de nuevas terapia\nDurante esta jornada\, expertos en Nanomedicina de diferentes campos -investigación\, empresa\, práctica clínica\, autoridades sanitarias\, pacientes\, etc.-\,  expondrán los últimos avances y nos darán la oportunidad de descubrir el generador de progreso que la Nanomedicina significa para la salud como creador de nuevas oportunidades en el diagnóstico y el tratamiento de las enfermedades minoritarias. \nInscripciones abiertas \n 
URL:https://ibecbarcelona.eu/event/nano-rare-diseade-day-2020-4/
LOCATION:Auditori J. Plaza\, Hospital Sant Joan de Déu\, Passeig de Sant Joan de Déu\, 2\, Esplugues de Llobregat\, Barcelona\, 08950 \, Spain
CATEGORIES:External symposium / conference / congress
ATTACH;FMTTYPE=image/png:https://ibecbarcelona.eu/wp-content/uploads/2020/02/rarediseasesday_banner-0x0-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200227T080000
DTEND;TZID=Europe/Madrid:20200227T170000
DTSTAMP:20260403T224657
CREATED:20200227T162601Z
LAST-MODIFIED:20200227T162601Z
UID:71805-1582790400-1582822800@ibecbarcelona.eu
SUMMARY:Taula rodona: el futur dels transplantaments
DESCRIPTION:Javier Ramón participará a la taula rodona: quin és el futur dels transplantaments?\nOrganitzat pel màster de comunicació científica\, mèdica i ambiental de la UPF-BSM.
URL:https://ibecbarcelona.eu/event/taula-rodona-el-futur-dels-transplantaments-2/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200226T183000
DTEND;TZID=Europe/Madrid:20200226T200000
DTSTAMP:20260403T224657
CREATED:20200227T161721Z
LAST-MODIFIED:20200227T161721Z
UID:71804-1582741800-1582747200@ibecbarcelona.eu
SUMMARY:Taula rodona: el futur dels transplantaments
DESCRIPTION:Javier Ramón participará a la taula rodona: quin és el futur dels transplantaments?\nOrganitzat pel màster de comunicació científica\, mèdica i ambiental de la UPF-BSM.
URL:https://ibecbarcelona.eu/event/taula-rodona-el-futur-dels-transplantaments/
LOCATION:UPF-BSM\, Calle Balmes 132 \, Barcelona\, 08008
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200224T113000
DTEND;TZID=Europe/Madrid:20200224T133000
DTSTAMP:20260403T224657
CREATED:20200205T152838Z
LAST-MODIFIED:20200205T152838Z
UID:96617-1582543800-1582551000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martí Checa
DESCRIPTION:A Novel Scanning Probe Microscopy technique to study the nanoscale electrical properties of cells\nMartí Checa\, Nanoscale bioelectrical characterization group \nThe goal of this work of thesis is the study of electrical properties in cells. That is the study of how they can conduct electricity\, accumulate charges\, or polarize. Experimental techniques able to measure electrical properties of complex heterogeneous samples (like cells) with excellent spatial resolution are needed to accomplish such characterization at the single-cell level (microscale) or even at the subcellular level (nanoscale). During this work of thesis\, a new experimental technique named “Scanning Dielectric Force Volume Microscopy (SDFVM)” has been developed together with the theoretical modeling for its understanding when operated in a liquid environment. \nThe technique has been validated with known samples (both in dry and liquid) and applied to many different nanometric systems of interest. The first full map of the local dielectric constant of a prokaryotic cell in dry conditions has been obtained with unparalleled accuracy and spatial resolution\, demonstrating its capability for label-free composition and structural mapping. Moreover\, the method has been applied to liquid environment\, obtaining the first-ever local dielectric contrast in fixed eukaryotic cells. Furthermore\, the first preliminary results in living cells have also been shown. SDFVM is expected to have an important impact not only in Life Sciences but also in Material Science\, where the mapping of the dielectric properties of samples showing complex nanoscale topographies is often needed. \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-marti-checa-2/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200224T113000
DTEND;TZID=Europe/Madrid:20200224T133000
DTSTAMP:20260403T224657
CREATED:20200205T152838Z
LAST-MODIFIED:20200205T152838Z
UID:96620-1582543800-1582551000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martí Checa
DESCRIPTION:A Novel Scanning Probe Microscopy technique to study the nanoscale electrical properties of cells\nMartí Checa\, Nanoscale bioelectrical characterization group \nThe goal of this work of thesis is the study of electrical properties in cells. That is the study of how they can conduct electricity\, accumulate charges\, or polarize. Experimental techniques able to measure electrical properties of complex heterogeneous samples (like cells) with excellent spatial resolution are needed to accomplish such characterization at the single-cell level (microscale) or even at the subcellular level (nanoscale). During this work of thesis\, a new experimental technique named “Scanning Dielectric Force Volume Microscopy (SDFVM)” has been developed together with the theoretical modeling for its understanding when operated in a liquid environment. \nThe technique has been validated with known samples (both in dry and liquid) and applied to many different nanometric systems of interest. The first full map of the local dielectric constant of a prokaryotic cell in dry conditions has been obtained with unparalleled accuracy and spatial resolution\, demonstrating its capability for label-free composition and structural mapping. Moreover\, the method has been applied to liquid environment\, obtaining the first-ever local dielectric contrast in fixed eukaryotic cells. Furthermore\, the first preliminary results in living cells have also been shown. SDFVM is expected to have an important impact not only in Life Sciences but also in Material Science\, where the mapping of the dielectric properties of samples showing complex nanoscale topographies is often needed. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-marti-checa-4/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200224T113000
DTEND;TZID=Europe/Madrid:20200224T133000
DTSTAMP:20260403T224657
CREATED:20200205T152838Z
LAST-MODIFIED:20200205T154546Z
UID:71058-1582543800-1582551000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martí Checa
DESCRIPTION:A Novel Scanning Probe Microscopy technique to study the nanoscale electrical properties of cells\nMartí Checa\, Nanoscale bioelectrical characterization group \nThe goal of this work of thesis is the study of electrical properties in cells. That is the study of how they can conduct electricity\, accumulate charges\, or polarize. Experimental techniques able to measure electrical properties of complex heterogeneous samples (like cells) with excellent spatial resolution are needed to accomplish such characterization at the single-cell level (microscale) or even at the subcellular level (nanoscale). During this work of thesis\, a new experimental technique named “Scanning Dielectric Force Volume Microscopy (SDFVM)” has been developed together with the theoretical modeling for its understanding when operated in a liquid environment. \nThe technique has been validated with known samples (both in dry and liquid) and applied to many different nanometric systems of interest. The first full map of the local dielectric constant of a prokaryotic cell in dry conditions has been obtained with unparalleled accuracy and spatial resolution\, demonstrating its capability for label-free composition and structural mapping. Moreover\, the method has been applied to liquid environment\, obtaining the first-ever local dielectric contrast in fixed eukaryotic cells. Furthermore\, the first preliminary results in living cells have also been shown. SDFVM is expected to have an important impact not only in Life Sciences but also in Material Science\, where the mapping of the dielectric properties of samples showing complex nanoscale topographies is often needed. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-marti-checa/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200224T113000
DTEND;TZID=Europe/Madrid:20200224T133000
DTSTAMP:20260403T224657
CREATED:20200205T152838Z
LAST-MODIFIED:20200205T152838Z
UID:96619-1582543800-1582551000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martí Checa
DESCRIPTION:A Novel Scanning Probe Microscopy technique to study the nanoscale electrical properties of cells\nMartí Checa\, Nanoscale bioelectrical characterization group \nThe goal of this work of thesis is the study of electrical properties in cells. That is the study of how they can conduct electricity\, accumulate charges\, or polarize. Experimental techniques able to measure electrical properties of complex heterogeneous samples (like cells) with excellent spatial resolution are needed to accomplish such characterization at the single-cell level (microscale) or even at the subcellular level (nanoscale). During this work of thesis\, a new experimental technique named “Scanning Dielectric Force Volume Microscopy (SDFVM)” has been developed together with the theoretical modeling for its understanding when operated in a liquid environment. \nThe technique has been validated with known samples (both in dry and liquid) and applied to many different nanometric systems of interest. The first full map of the local dielectric constant of a prokaryotic cell in dry conditions has been obtained with unparalleled accuracy and spatial resolution\, demonstrating its capability for label-free composition and structural mapping. Moreover\, the method has been applied to liquid environment\, obtaining the first-ever local dielectric contrast in fixed eukaryotic cells. Furthermore\, the first preliminary results in living cells have also been shown. SDFVM is expected to have an important impact not only in Life Sciences but also in Material Science\, where the mapping of the dielectric properties of samples showing complex nanoscale topographies is often needed. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-marti-checa-3/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200214T100000
DTEND;TZID=Europe/Madrid:20200214T170000
DTSTAMP:20260403T224658
CREATED:20200205T084744Z
LAST-MODIFIED:20200205T084744Z
UID:96613-1581674400-1581699600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Vendrell
DESCRIPTION:Translational chemistry\, optical imaging and precision medicine\nMarc Vendrell \, University of Edinburgh \nOptical imaging has revolutionised our understanding of how biological systems behave at the molecular level. In the last years\, my group has developed dynamic activatable fluorophores (DYNAFLUORS) as chemical tools to image the function and activity of immune cells in disease. We have used the probes to interrogate the dynamics of biology in real time and also translated some of them for clinical applications\, including first-in-human studies. My group is currently focused on creating new probes that can help us understand the roles that specific subsets of immune cells play in the tumour microenvironment and improve personalised therapeutic approaches.\nGroup website: www.dynafluors.co.uk \nMarc Vendrell graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in the design of synthetic fluorophores for optical imaging. In 2012 he started his independent career as an MRC Academic Fellow at the University of Edinburgh and is now a Senior Lecturer in Biomedical Imaging. He has over 90 publications\, including 11 patents with multiple fluorescent probes being commercialised by Merck and Biolegend and some currently undergoing clinical studies. His research has been recognised with several international awards and distinctions\, including an ERC Consolidator Grant (2017)\, the Marcial Moreno Lectureship (2018) and the SRUK Emerging Talent Award (2019). \nHe has been invited to Sílvia Pujals and Lorenzo Albertazzi
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-vendrell/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200214T100000
DTEND;TZID=Europe/Madrid:20200214T170000
DTSTAMP:20260403T224658
CREATED:20200205T084744Z
LAST-MODIFIED:20200205T084744Z
UID:96614-1581674400-1581699600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Vendrell
DESCRIPTION:Translational chemistry\, optical imaging and precision medicine\nMarc Vendrell \, University of Edinburgh \nOptical imaging has revolutionised our understanding of how biological systems behave at the molecular level. In the last years\, my group has developed dynamic activatable fluorophores (DYNAFLUORS) as chemical tools to image the function and activity of immune cells in disease. We have used the probes to interrogate the dynamics of biology in real time and also translated some of them for clinical applications\, including first-in-human studies. My group is currently focused on creating new probes that can help us understand the roles that specific subsets of immune cells play in the tumour microenvironment and improve personalised therapeutic approaches.\nGroup website: www.dynafluors.co.uk \nMarc Vendrell graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in the design of synthetic fluorophores for optical imaging. In 2012 he started his independent career as an MRC Academic Fellow at the University of Edinburgh and is now a Senior Lecturer in Biomedical Imaging. He has over 90 publications\, including 11 patents with multiple fluorescent probes being commercialised by Merck and Biolegend and some currently undergoing clinical studies. His research has been recognised with several international awards and distinctions\, including an ERC Consolidator Grant (2017)\, the Marcial Moreno Lectureship (2018) and the SRUK Emerging Talent Award (2019). \nHe has been invited to Sílvia Pujals and Lorenzo Albertazzi
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-vendrell/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200214T100000
DTEND;TZID=Europe/Madrid:20200214T120000
DTSTAMP:20260403T224658
CREATED:20200130T145950Z
LAST-MODIFIED:20200203T160844Z
UID:70818-1581674400-1581681600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Vendrell
DESCRIPTION:Translational chemistry\, optical imaging and precision medicine\nMarc Vendrell \, University of Edinburgh \nOptical imaging has revolutionised our understanding of how biological systems behave at the molecular level. In the last years\, my group has developed dynamic activatable fluorophores (DYNAFLUORS) as chemical tools to image the function and activity of immune cells in disease. We have used the probes to interrogate the dynamics of biology in real time and also translated some of them for clinical applications\, including first-in-human studies. My group is currently focused on creating new probes that can help us understand the roles that specific subsets of immune cells play in the tumour microenvironment and improve personalised therapeutic approaches.\nGroup website: www.dynafluors.co.uk \nMarc Vendrell graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in the design of synthetic fluorophores for optical imaging. In 2012 he started his independent career as an MRC Academic Fellow at the University of Edinburgh and is now a Senior Lecturer in Biomedical Imaging. He has over 90 publications\, including 11 patents with multiple fluorescent probes being commercialised by Merck and Biolegend and some currently undergoing clinical studies. His research has been recognised with several international awards and distinctions\, including an ERC Consolidator Grant (2017)\, the Marcial Moreno Lectureship (2018) and the SRUK Emerging Talent Award (2019). \nHe has been invited to Sílvia Pujals and Lorenzo Albertazzi
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200214T100000
DTEND;TZID=Europe/Madrid:20200214T120000
DTSTAMP:20260403T224658
CREATED:20200130T145950Z
LAST-MODIFIED:20200130T145950Z
UID:96600-1581674400-1581681600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Vendrell
DESCRIPTION:Translational chemistry\, optical imaging and precision medicine\nMarc Vendrell \, University of Edinburgh \nOptical imaging has revolutionised our understanding of how biological systems behave at the molecular level. In the last years\, my group has developed dynamic activatable fluorophores (DYNAFLUORS) as chemical tools to image the function and activity of immune cells in disease. We have used the probes to interrogate the dynamics of biology in real time and also translated some of them for clinical applications\, including first-in-human studies. My group is currently focused on creating new probes that can help us understand the roles that specific subsets of immune cells play in the tumour microenvironment and improve personalised therapeutic approaches.\nGroup website: www.dynafluors.co.uk \nMarc Vendrell graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in the design of synthetic fluorophores for optical imaging. In 2012 he started his independent career as an MRC Academic Fellow at the University of Edinburgh and is now a Senior Lecturer in Biomedical Imaging. He has over 90 publications\, including 11 patents with multiple fluorescent probes being commercialised by Merck and Biolegend and some currently undergoing clinical studies. His research has been recognised with several international awards and distinctions\, including an ERC Consolidator Grant (2017)\, the Marcial Moreno Lectureship (2018) and the SRUK Emerging Talent Award (2019). \nHe has been invited to Sílvia Pujals and Lorenzo Albertazzi
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200211T080000
DTEND;TZID=Europe/Madrid:20200211T170000
DTSTAMP:20260403T224658
CREATED:20200227T160505Z
LAST-MODIFIED:20200227T160505Z
UID:96635-1581408000-1581440400@ibecbarcelona.eu
SUMMARY:100tífiques
DESCRIPTION:Amb motiu del Dia Internacional de la Dona i la Nena en Ciència\, investigadores de l’IBEC van anar a diferents escoles catalanes per fer una presentació sobre dones i ciència per animar als alumnes a estudiar carreres STEAM. \nA més\, com l’IBEC té una col·laboració amb l’ “Escola Gayarre” en el marc del Projecte Magnet\, alguns dels nostres investigadors van visitar les seves aules per parlar també sobre dones i ciència.
URL:https://ibecbarcelona.eu/event/100tifiques-3/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200211T080000
DTEND;TZID=Europe/Madrid:20200211T170000
DTSTAMP:20260403T224658
CREATED:20200227T160505Z
LAST-MODIFIED:20200227T160505Z
UID:71793-1581408000-1581440400@ibecbarcelona.eu
SUMMARY:100tífiques
DESCRIPTION:On the occasion of the International Day of Woman and Girls in Science researchers from IBEC went to different catalan schools to give a presentation of women in science to encourage all kids to study STEAM digrees. \nFurthermore\, as IBEC has a partnership with the elementary school “Escola Gayarre” within the frame of the “Magnet Projects” some of our researchers visited their classrooms and also gave an oran exposition of women in science.
URL:https://ibecbarcelona.eu/event/100tifiques/
LOCATION:IBEC\, Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200211T080000
DTEND;TZID=Europe/Madrid:20200211T170000
DTSTAMP:20260403T224658
CREATED:20200227T160505Z
LAST-MODIFIED:20200227T160505Z
UID:96634-1581408000-1581440400@ibecbarcelona.eu
SUMMARY:100tífiques
DESCRIPTION:On the occasion of the International Day of Woman and Girls in Science researchers from IBEC went to different catalan schools to give a presentation of women in science to encourage all kids to study STEAM digrees. \nFurthermore\, as IBEC has a partnership with the elementary school “Escola Gayarre” within the frame of the “Magnet Projects” some of our researchers visited their classrooms and also gave an oran exposition of women in science.
URL:https://ibecbarcelona.eu/event/100tifiques-2/
LOCATION:IBEC\, Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200210T083000
DTEND;TZID=Europe/Madrid:20200212T133000
DTSTAMP:20260403T224658
CREATED:20191009T144633Z
LAST-MODIFIED:20191009T144633Z
UID:96515-1581323400-1581514200@ibecbarcelona.eu
SUMMARY:EMBL·IBEC Winter Conference #EIWC20
DESCRIPTION:ENGINEERING MULTICELLULAR SYSTEMS\nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos\n \nThis conference will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \nThe conference will take place in La Pedrera Auditorium\, one of Gaudí’s architectural masterpieces in Barcelona from 10-12th February 2020. We expect to bring together 150 researchers including stem cell biologists\, systems biologists\, physicists and engineers.
URL:https://ibecbarcelona.eu/event/embl-ibec-winter-conference-on-engineering-multicellular-systems-4/
LOCATION:La Pedrera
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200210T083000
DTEND;TZID=Europe/Madrid:20200212T133000
DTSTAMP:20260403T224658
CREATED:20191009T144633Z
LAST-MODIFIED:20191009T144633Z
UID:96513-1581323400-1581514200@ibecbarcelona.eu
SUMMARY:EMBL·IBEC Winter Conference #EIWC20
DESCRIPTION:ENGINEERING MULTICELLULAR SYSTEMS\nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos\n \nThis conference will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \nThe conference will take place in La Pedrera Auditorium\, one of Gaudí’s architectural masterpieces in Barcelona from 10-12th February 2020. We expect to bring together 150 researchers including stem cell biologists\, systems biologists\, physicists and engineers.
URL:https://ibecbarcelona.eu/event/embl-ibec-winter-conference-on-engineering-multicellular-systems-2/
LOCATION:La Pedrera
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200210T083000
DTEND;TZID=Europe/Madrid:20200212T133000
DTSTAMP:20260403T224658
CREATED:20191009T144633Z
LAST-MODIFIED:20200207T084041Z
UID:68612-1581323400-1581514200@ibecbarcelona.eu
SUMMARY:EMBL·IBEC Winter Conference #EIWC20
DESCRIPTION:ENGINEERING MULTICELLULAR SYSTEMS\nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos\n \nThis conference will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \nThe conference will take place in La Pedrera Auditorium\, one of Gaudí’s architectural masterpieces in Barcelona from 10-12th February 2020. We expect to bring together 150 researchers including stem cell biologists\, systems biologists\, physicists and engineers.
URL:https://ibecbarcelona.eu/event/embl-ibec-winter-conference-on-engineering-multicellular-systems/
LOCATION:La Pedrera
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200210T083000
DTEND;TZID=Europe/Madrid:20200212T133000
DTSTAMP:20260403T224658
CREATED:20191009T144633Z
LAST-MODIFIED:20191009T144633Z
UID:96514-1581323400-1581514200@ibecbarcelona.eu
SUMMARY:EMBL·IBEC Winter Conference #EIWC20
DESCRIPTION:ENGINEERING MULTICELLULAR SYSTEMS\nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos\n \nThis conference will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \nThe conference will take place in La Pedrera Auditorium\, one of Gaudí’s architectural masterpieces in Barcelona from 10-12th February 2020. We expect to bring together 150 researchers including stem cell biologists\, systems biologists\, physicists and engineers.
URL:https://ibecbarcelona.eu/event/embl-ibec-winter-conference-on-engineering-multicellular-systems-3/
LOCATION:La Pedrera
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200207T100000
DTEND;TZID=Europe/Madrid:20200207T120000
DTSTAMP:20260403T224658
CREATED:20200203T154847Z
LAST-MODIFIED:20200203T154847Z
UID:96605-1581069600-1581076800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gema Esquiva
DESCRIPTION:Alteraciones en el sistema melanopsínico en la retinosis pigmentaria y durante el proceso de envejecimiento\nGema Esquiva \, Universitat d’Alacant \nLa retinosis pigmentaria es la degeneración hereditaria de la retina más frecuente\, siendo la cuarta causa de ceguera en el mundo. Además\, en esta enfermedad\, se producen alteraciones en los ritmos circadianos\, esenciales para llevar una vida saludable\, ya que estas alteraciones se relacionan con aumento en el estrés\, insomnio\, depresión y muchas otras patologías. La regulación de los ritmos circadianos se lleva a cabo a través de un tipo de células ganglionares de la retina\, las células melanopsínicas. \nEn este trabajo se describen los diferentes tipos de células ganglionares melanopsínicas en la retina humana\, en la retina de rata y en un modelo animal de retinosis pigmentaria. Además\, evaluamos los cambios morfológicos y de densidad producidos en estas células\, y estudiamos los efectos producidos en los patrones circadianos durante la progresiva degeneración retiniana que ocurre en esta enfermedad. También evaluamos el efecto neuroprotector de la administración de melatonina exógena. \nEl estudio morfológico de la retina en estos animales puso de manifiesto la existencia de 3 tipos de células melanopsínicas en rata de las cuales únicamente dos habían sido descritas hasta el momento. Por otro lado\, observamos una disminución y degeneración de estas células\, asociada a la retinosis pigmentaria y al envejecimiento. \nLos resultados obtenidos mediante técnicas electrorretinográficas y mediante los registros de temperatura corporal y de actividad locomotora desvelaron que los animales modelo de retinosis pigmentaria tenían menor respuesta visual y una alteración de los ritmos circadianos. Los animales modelo de retinosis pigmentaria tratados con melatonina mostraron mayor respuesta visual y mejor regulación de los ritmos circadianos que los animales modelo sin tratar. \nEstos resultados indican que en modelos de retinosis pigmentaria la degeneración de los fotorreceptores clásicos se acompaña de un proceso de remodelación de la retina interna que afecta al sistema melanopsínico. Deducimos que la alteración en los ritmos circadianos se manifiesta a partir de las alteraciones observadas en la densidad y en los procesos dendríticos de las células ganglionares melanopsínicas. En este sentido\, la melatonina ejerce un efecto neuroprotector sobre los fotorreceptores en degeneración\, conos\, bastones y células melanopsínicas de la retina. Por otro lado\, tras el estudio de las retinas humanas concluimos que el envejecimiento se asocia con una pérdida de densidad y arborización dendrítica de las células melanopsínicas lo que posiblemente explica la aparición más frecuente de trastornos del ritmo circadiano en personas de edad avanzada. \nHa sido invitada al IBEC por Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-gema-esquiva-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200207T100000
DTEND;TZID=Europe/Madrid:20200207T120000
DTSTAMP:20260403T224658
CREATED:20200203T154847Z
LAST-MODIFIED:20200203T154847Z
UID:96607-1581069600-1581076800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gema Esquiva
DESCRIPTION:Alteraciones en el sistema melanopsínico en la retinosis pigmentaria y durante el proceso de envejecimiento\nGema Esquiva \, Universitat d’Alacant \nLa retinosis pigmentaria es la degeneración hereditaria de la retina más frecuente\, siendo la cuarta causa de ceguera en el mundo. Además\, en esta enfermedad\, se producen alteraciones en los ritmos circadianos\, esenciales para llevar una vida saludable\, ya que estas alteraciones se relacionan con aumento en el estrés\, insomnio\, depresión y muchas otras patologías. La regulación de los ritmos circadianos se lleva a cabo a través de un tipo de células ganglionares de la retina\, las células melanopsínicas. \nEn este trabajo se describen los diferentes tipos de células ganglionares melanopsínicas en la retina humana\, en la retina de rata y en un modelo animal de retinosis pigmentaria. Además\, evaluamos los cambios morfológicos y de densidad producidos en estas células\, y estudiamos los efectos producidos en los patrones circadianos durante la progresiva degeneración retiniana que ocurre en esta enfermedad. También evaluamos el efecto neuroprotector de la administración de melatonina exógena. \nEl estudio morfológico de la retina en estos animales puso de manifiesto la existencia de 3 tipos de células melanopsínicas en rata de las cuales únicamente dos habían sido descritas hasta el momento. Por otro lado\, observamos una disminución y degeneración de estas células\, asociada a la retinosis pigmentaria y al envejecimiento. \nLos resultados obtenidos mediante técnicas electrorretinográficas y mediante los registros de temperatura corporal y de actividad locomotora desvelaron que los animales modelo de retinosis pigmentaria tenían menor respuesta visual y una alteración de los ritmos circadianos. Los animales modelo de retinosis pigmentaria tratados con melatonina mostraron mayor respuesta visual y mejor regulación de los ritmos circadianos que los animales modelo sin tratar. \nEstos resultados indican que en modelos de retinosis pigmentaria la degeneración de los fotorreceptores clásicos se acompaña de un proceso de remodelación de la retina interna que afecta al sistema melanopsínico. Deducimos que la alteración en los ritmos circadianos se manifiesta a partir de las alteraciones observadas en la densidad y en los procesos dendríticos de las células ganglionares melanopsínicas. En este sentido\, la melatonina ejerce un efecto neuroprotector sobre los fotorreceptores en degeneración\, conos\, bastones y células melanopsínicas de la retina. Por otro lado\, tras el estudio de las retinas humanas concluimos que el envejecimiento se asocia con una pérdida de densidad y arborización dendrítica de las células melanopsínicas lo que posiblemente explica la aparición más frecuente de trastornos del ritmo circadiano en personas de edad avanzada. \nHa sido invitada al IBEC por Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-gema-esquiva-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200207T100000
DTEND;TZID=Europe/Madrid:20200207T120000
DTSTAMP:20260403T224658
CREATED:20200203T154847Z
LAST-MODIFIED:20200203T154847Z
UID:70948-1581069600-1581076800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gema Esquiva
DESCRIPTION:Alteraciones en el sistema melanopsínico en la retinosis pigmentaria y durante el proceso de envejecimiento\nGema Esquiva \, Universitat d’Alacant \nLa retinosis pigmentaria es la degeneración hereditaria de la retina más frecuente\, siendo la cuarta causa de ceguera en el mundo. Además\, en esta enfermedad\, se producen alteraciones en los ritmos circadianos\, esenciales para llevar una vida saludable\, ya que estas alteraciones se relacionan con aumento en el estrés\, insomnio\, depresión y muchas otras patologías. La regulación de los ritmos circadianos se lleva a cabo a través de un tipo de células ganglionares de la retina\, las células melanopsínicas. \nEn este trabajo se describen los diferentes tipos de células ganglionares melanopsínicas en la retina humana\, en la retina de rata y en un modelo animal de retinosis pigmentaria. Además\, evaluamos los cambios morfológicos y de densidad producidos en estas células\, y estudiamos los efectos producidos en los patrones circadianos durante la progresiva degeneración retiniana que ocurre en esta enfermedad. También evaluamos el efecto neuroprotector de la administración de melatonina exógena. \nEl estudio morfológico de la retina en estos animales puso de manifiesto la existencia de 3 tipos de células melanopsínicas en rata de las cuales únicamente dos habían sido descritas hasta el momento. Por otro lado\, observamos una disminución y degeneración de estas células\, asociada a la retinosis pigmentaria y al envejecimiento. \nLos resultados obtenidos mediante técnicas electrorretinográficas y mediante los registros de temperatura corporal y de actividad locomotora desvelaron que los animales modelo de retinosis pigmentaria tenían menor respuesta visual y una alteración de los ritmos circadianos. Los animales modelo de retinosis pigmentaria tratados con melatonina mostraron mayor respuesta visual y mejor regulación de los ritmos circadianos que los animales modelo sin tratar. \nEstos resultados indican que en modelos de retinosis pigmentaria la degeneración de los fotorreceptores clásicos se acompaña de un proceso de remodelación de la retina interna que afecta al sistema melanopsínico. Deducimos que la alteración en los ritmos circadianos se manifiesta a partir de las alteraciones observadas en la densidad y en los procesos dendríticos de las células ganglionares melanopsínicas. En este sentido\, la melatonina ejerce un efecto neuroprotector sobre los fotorreceptores en degeneración\, conos\, bastones y células melanopsínicas de la retina. Por otro lado\, tras el estudio de las retinas humanas concluimos que el envejecimiento se asocia con una pérdida de densidad y arborización dendrítica de las células melanopsínicas lo que posiblemente explica la aparición más frecuente de trastornos del ritmo circadiano en personas de edad avanzada. \nHa sido invitada al IBEC por Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-gema-esquiva/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200207T100000
DTEND;TZID=Europe/Madrid:20200207T120000
DTSTAMP:20260403T224658
CREATED:20200203T154847Z
LAST-MODIFIED:20200203T154847Z
UID:96609-1581069600-1581076800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gema Esquiva
DESCRIPTION:Alteraciones en el sistema melanopsínico en la retinosis pigmentaria y durante el proceso de envejecimiento\nGema Esquiva \, Universitat d’Alacant \nLa retinosis pigmentaria es la degeneración hereditaria de la retina más frecuente\, siendo la cuarta causa de ceguera en el mundo. Además\, en esta enfermedad\, se producen alteraciones en los ritmos circadianos\, esenciales para llevar una vida saludable\, ya que estas alteraciones se relacionan con aumento en el estrés\, insomnio\, depresión y muchas otras patologías. La regulación de los ritmos circadianos se lleva a cabo a través de un tipo de células ganglionares de la retina\, las células melanopsínicas. \nEn este trabajo se describen los diferentes tipos de células ganglionares melanopsínicas en la retina humana\, en la retina de rata y en un modelo animal de retinosis pigmentaria. Además\, evaluamos los cambios morfológicos y de densidad producidos en estas células\, y estudiamos los efectos producidos en los patrones circadianos durante la progresiva degeneración retiniana que ocurre en esta enfermedad. También evaluamos el efecto neuroprotector de la administración de melatonina exógena. \nEl estudio morfológico de la retina en estos animales puso de manifiesto la existencia de 3 tipos de células melanopsínicas en rata de las cuales únicamente dos habían sido descritas hasta el momento. Por otro lado\, observamos una disminución y degeneración de estas células\, asociada a la retinosis pigmentaria y al envejecimiento. \nLos resultados obtenidos mediante técnicas electrorretinográficas y mediante los registros de temperatura corporal y de actividad locomotora desvelaron que los animales modelo de retinosis pigmentaria tenían menor respuesta visual y una alteración de los ritmos circadianos. Los animales modelo de retinosis pigmentaria tratados con melatonina mostraron mayor respuesta visual y mejor regulación de los ritmos circadianos que los animales modelo sin tratar. \nEstos resultados indican que en modelos de retinosis pigmentaria la degeneración de los fotorreceptores clásicos se acompaña de un proceso de remodelación de la retina interna que afecta al sistema melanopsínico. Deducimos que la alteración en los ritmos circadianos se manifiesta a partir de las alteraciones observadas en la densidad y en los procesos dendríticos de las células ganglionares melanopsínicas. En este sentido\, la melatonina ejerce un efecto neuroprotector sobre los fotorreceptores en degeneración\, conos\, bastones y células melanopsínicas de la retina. Por otro lado\, tras el estudio de las retinas humanas concluimos que el envejecimiento se asocia con una pérdida de densidad y arborización dendrítica de las células melanopsínicas lo que posiblemente explica la aparición más frecuente de trastornos del ritmo circadiano en personas de edad avanzada. \nHa sido invitada al IBEC por Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-gema-esquiva-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200206T110000
DTEND;TZID=Europe/Madrid:20200206T130000
DTSTAMP:20260403T224658
CREATED:20200205T084613Z
LAST-MODIFIED:20200205T084613Z
UID:71046-1580986800-1580994000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Andela Saric
DESCRIPTION:How to build a biological nanomachine\nAndela Saric \, University College London \nThe molecular machinery of life is largely created via self-organisation of individual molecules into functional larger-scaled structures. Such processes are multi-scale in nature and constantly driven far from thermodynamic equilibrium. Our group develops minimal coarse-grained computer models to help understand how the assembly of a large number of macromolecules results in a functional nanomachine\, as well as how such processes can go wrong\, leading to diseases. \nHere I will discuss the physical mechanisms behind two key biological nanomachines that operate via protein assembly – active elastic ESCRT-III filaments that remodel and cut cell membranes and split cells in two\, and bacterial mechanosensitive protein channels that convert mechanical signals into chemical. I will discuss the model development\, simulation results\, and the mapping of the simulation data to in vivo experiments. Beyond their biological context\, our findings can guide the design of artificial structures that are able to manipulate cell membranes and perform work at the nanoscale. \nAndela is an Associate Professor in the Department of Physics and Astronomy and Laboratory for Molecular Cell Biology at University College London. She obtained her PhD from Columbia University in 2013\, followed by postdoctoral research at the University of Cambridge. Andela works in the area of computational biological physics\, developing minimal models to study biological assembly and cell remodelling. She is a recipient of the ERC Starting Grant\, Royal Society University Research Fellowship\, and HFSP Cross-disciplinary Fellowship. \nShe has been invited to IBEC by Josep Samitier
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric-2/
LOCATION:Felix Serratosa\, Baldiri Reixac\, 10-12\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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