BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220509T183000
DTEND;TZID=Europe/Madrid:20220511T210000
DTSTAMP:20260403T224657
CREATED:20220504T115535Z
LAST-MODIFIED:20220504T115535Z
UID:96608-1652121000-1652302800@ibecbarcelona.eu
SUMMARY:Pint of Science 2022
DESCRIPTION:Monica Mir de Nanobioengineering\,  Agustín Gutierrez de Signal and Information Processing for Sensing Systems y  Silvia Pujals de Nanoscopy for nanomedicine participarán en el evento global de divulgación científica Pint of Science. \nEl festival Pint of Science\, que se celebrará del 09 al 11 de mayo\, tiene como objetivo ofrecer charlas interesantes\, divertidas y relevantes sobre las últimas investigaciones científicas de la mano de las personas que las llevan a cabo. \n  \nLunes\, 9 de mayo:  \n\nMonica Mir “¿Como funcionan los test para detección de COVID?”\nAgustín Gutierrez “Una nueva inteligencia para controlar el mundo”\n\nMartes 10 de mayo: \n\nSilvia Pujals “Nanopartículas para la medicina. ¿Promesa o realidad?”\n\n  \n\n\n\n\nSi quieres más información\, visita: Eventos de Barcelona | Pint of Science ES. \nPodéis ver el cartel aquí.
URL:https://ibecbarcelona.eu/event/pint-of-science-2022/
LOCATION:Careers at IBEC
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220512T101500
DTEND;TZID=Europe/Madrid:20220512T140000
DTSTAMP:20260403T224657
CREATED:20220419T073953Z
LAST-MODIFIED:20220419T073953Z
UID:96584-1652350500-1652364000@ibecbarcelona.eu
SUMMARY:Research4Talent 2022
DESCRIPTION:On Thursday 12th May 2022 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2021 IBEC signed more that 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s eighth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research4talent-2022/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220512T101500
DTEND;TZID=Europe/Madrid:20220512T140000
DTSTAMP:20260403T224657
CREATED:20220419T073953Z
LAST-MODIFIED:20220419T073953Z
UID:96585-1652350500-1652364000@ibecbarcelona.eu
SUMMARY:Research4Talent 2022
DESCRIPTION:On Thursday 12th May 2022 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2021 IBEC signed more that 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s eighth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research4talent-2022-2/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220512T101500
DTEND;TZID=Europe/Madrid:20220512T140000
DTSTAMP:20260403T224657
CREATED:20220419T073953Z
LAST-MODIFIED:20220419T073953Z
UID:96588-1652350500-1652364000@ibecbarcelona.eu
SUMMARY:Research4Talent 2022
DESCRIPTION:On Thursday 12th May 2022 we’ll open our doors to UNDERGRADUATE & MASTER’s students interested in a research career\n \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc. \nIn 2021 IBEC signed more that 165 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. If you are interested in IBEC’s eighth edition of reSEARCH4TALENT\, please register now.
URL:https://ibecbarcelona.eu/event/research4talent-2022-3/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220513T100000
DTEND;TZID=Europe/Madrid:20220513T120000
DTSTAMP:20260403T224657
CREATED:20220503T130848Z
LAST-MODIFIED:20220503T130848Z
UID:96597-1652436000-1652443200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Iris Batalha
DESCRIPTION:Nanotherapeutics – ‘How we sometimes underestimate the influence of little things’\nIris L. Batalha\, Institute for Bioengineering of Catalonia (IBEC) \nDeaths caused by infections from antibiotic-resistant bacteria are expected to skyrocket over the next decades\, with a staggering 10 million deaths per year projected for 2050. Treating infections by intracellular pathogens\, such as M. tuberculosis\, is ‘a perfect storm’. The WHO revealed that while some 50 new antibiotics and 10 biologics are under development\, only half of those target WHO-priority pathogens and the majority have very limited benefits when compared to existing antibiotics. Reformulating existent drugs in nanocarriers may help achieving enhanced efficacy and safety while reducing dose frequency\, by providing temporal and localised control of drug exposure. In this talk\, I will present my work on the synthesis of dual-drug tunable nanoparticle-based antibiotics\, which showed increased bacterial killing efficacy in a zebrafish larval model of mycobacterial infection when compared to free drugs at the same concentration. In addition\, nanoparticles were able to efficiently penetrate mycobacterial cords and granulomatous lesions – shielded regions of difficult access by free drugs\, improving the therapeutic effect. \n\nIris Batalha is currently a Junior Leader Research Fellow at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona\, a Panel Tutor in Nanotherapeutics at the University of Cambridge Institute of Continuing Education\, a freelance Senior Innovation Consultant at Inspiralia (Spain and USA)\, a Co-founder\, Director and Editor-in-Chief of the non-profit organisation Women Ahead of Their Time (WATT)\, and a Research Associate at Peterhouse College. From 2017 to 2020\, she was a joint Research Associate at the Department of Engineering Nanoscience Centre and Department of Medicine Molecular Immunity Unit\, University of Cambridge. From 2014 to 2017\, she worked at the Department of Chemical Engineering and Biotechnology\, University of Cambridge\, and the biopharmaceutical company MedImmune/Astrazeneca\, followed by a brief experience as a healthcare/pharmaceutical consultant. Her research interests and expertise lie in medical and pharmaceutical research and development\, particularly in the fields of nanobiotechnology\, bio-inspired materials\, downstream processing\, formulation and drug delivery. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-discussions-iris-batalha-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220513T100000
DTEND;TZID=Europe/Madrid:20220513T120000
DTSTAMP:20260403T224657
CREATED:20220503T130848Z
LAST-MODIFIED:20220503T130848Z
UID:91647-1652436000-1652443200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Iris Batalha
DESCRIPTION:Nanotherapeutics – ‘How we sometimes underestimate the influence of little things’\nIris L. Batalha\, Institute for Bioengineering of Catalonia (IBEC) \nDeaths caused by infections from antibiotic-resistant bacteria are expected to skyrocket over the next decades\, with a staggering 10 million deaths per year projected for 2050. Treating infections by intracellular pathogens\, such as M. tuberculosis\, is ‘a perfect storm’. The WHO revealed that while some 50 new antibiotics and 10 biologics are under development\, only half of those target WHO-priority pathogens and the majority have very limited benefits when compared to existing antibiotics. Reformulating existent drugs in nanocarriers may help achieving enhanced efficacy and safety while reducing dose frequency\, by providing temporal and localised control of drug exposure. In this talk\, I will present my work on the synthesis of dual-drug tunable nanoparticle-based antibiotics\, which showed increased bacterial killing efficacy in a zebrafish larval model of mycobacterial infection when compared to free drugs at the same concentration. In addition\, nanoparticles were able to efficiently penetrate mycobacterial cords and granulomatous lesions – shielded regions of difficult access by free drugs\, improving the therapeutic effect. \n\nIris Batalha is currently a Junior Leader Research Fellow at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona\, a Panel Tutor in Nanotherapeutics at the University of Cambridge Institute of Continuing Education\, a freelance Senior Innovation Consultant at Inspiralia (Spain and USA)\, a Co-founder\, Director and Editor-in-Chief of the non-profit organisation Women Ahead of Their Time (WATT)\, and a Research Associate at Peterhouse College. From 2017 to 2020\, she was a joint Research Associate at the Department of Engineering Nanoscience Centre and Department of Medicine Molecular Immunity Unit\, University of Cambridge. From 2014 to 2017\, she worked at the Department of Chemical Engineering and Biotechnology\, University of Cambridge\, and the biopharmaceutical company MedImmune/Astrazeneca\, followed by a brief experience as a healthcare/pharmaceutical consultant. Her research interests and expertise lie in medical and pharmaceutical research and development\, particularly in the fields of nanobiotechnology\, bio-inspired materials\, downstream processing\, formulation and drug delivery. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-discussions-iris-batalha/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220513T100000
DTEND;TZID=Europe/Madrid:20220513T120000
DTSTAMP:20260403T224657
CREATED:20220503T130848Z
LAST-MODIFIED:20220503T130848Z
UID:91649-1652436000-1652443200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Iris Batalha
DESCRIPTION:Nanotherapeutics – ‘How we sometimes underestimate the influence of little things’\nIris L. Batalha\, Institute for Bioengineering of Catalonia (IBEC) \nDeaths caused by infections from antibiotic-resistant bacteria are expected to skyrocket over the next decades\, with a staggering 10 million deaths per year projected for 2050. Treating infections by intracellular pathogens\, such as M. tuberculosis\, is ‘a perfect storm’. The WHO revealed that while some 50 new antibiotics and 10 biologics are under development\, only half of those target WHO-priority pathogens and the majority have very limited benefits when compared to existing antibiotics. Reformulating existent drugs in nanocarriers may help achieving enhanced efficacy and safety while reducing dose frequency\, by providing temporal and localised control of drug exposure. In this talk\, I will present my work on the synthesis of dual-drug tunable nanoparticle-based antibiotics\, which showed increased bacterial killing efficacy in a zebrafish larval model of mycobacterial infection when compared to free drugs at the same concentration. In addition\, nanoparticles were able to efficiently penetrate mycobacterial cords and granulomatous lesions – shielded regions of difficult access by free drugs\, improving the therapeutic effect. \n\nIris Batalha is currently a Junior Leader Research Fellow at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona\, a Panel Tutor in Nanotherapeutics at the University of Cambridge Institute of Continuing Education\, a freelance Senior Innovation Consultant at Inspiralia (Spain and USA)\, a Co-founder\, Director and Editor-in-Chief of the non-profit organisation Women Ahead of Their Time (WATT)\, and a Research Associate at Peterhouse College. From 2017 to 2020\, she was a joint Research Associate at the Department of Engineering Nanoscience Centre and Department of Medicine Molecular Immunity Unit\, University of Cambridge. From 2014 to 2017\, she worked at the Department of Chemical Engineering and Biotechnology\, University of Cambridge\, and the biopharmaceutical company MedImmune/Astrazeneca\, followed by a brief experience as a healthcare/pharmaceutical consultant. Her research interests and expertise lie in medical and pharmaceutical research and development\, particularly in the fields of nanobiotechnology\, bio-inspired materials\, downstream processing\, formulation and drug delivery. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/phd-discussions-iris-batalha-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220527T100000
DTEND;TZID=Europe/Madrid:20220527T120000
DTSTAMP:20260403T224657
CREATED:20220503T132210Z
LAST-MODIFIED:20220503T132210Z
UID:91658-1653645600-1653652800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Srivatsava Viswanadha Venkata Naga Sai and Madhura Murar
DESCRIPTION:Mechanical characterization of murine pluripotency dissolution\nSrivatsava Viswanadha Venkata Naga Sai\, Cellular and Molecular Mechanobiology Group \nMouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal\, mESCs exit naïve state and become functionally mature\, acquiring differentiation competence. From a mechanical point of view\, the instruction for initiating ground state exit is the integrin mediated mechano-sensing of extra cellular matrix (ECM). Although laminin has been found to be the pivotal ECM ligand for pluripotency dissolution\, the down-stream mechano-responses accompanying its sensing\, their spatio-temporal evolution and\, their regulatory role in mESC maturation remain unclear. In this work\, we combine mechanical measurements\, functional characterization\, and live cell imaging to unravel the role of mESCs-ECM interactions during naïve state exit and pluripotency dissolution. We employ a Rex1::GFPd2 expressing mESC line to monitor naïve state exit in real time\, combined with a laminin-rich ECM environment. During naïve state exit\, we observe a progressive increase in cell-ECM interaction\, marked by an increase in traction forces\, growth of focal adhesions\, and the reorganization of the basal actin from a mesh-like network into an oriented filamentous morphology reminiscent of stress fibres. Furthermore\, inhibition of non-muscle myosin-II using blebbistatin significantly delayed naïve state exit\, suggesting a regulatory role of cell contractility in mESC maturation. We finally investigate the role of these changes in cell-ECM interactions in mediating nuclear mechanoresponses\, and their influence in mESC pluripotency dissolution. \n\n\nDual peptide-mediated design of polymeric nanoparticles: towards precision prostate cancer targeting\nMadhura Murar\, Nanoscopy for Nanomedicine Group \nA key bottleneck of current cancer treatments is the lack of selective targeting of cancer cells to reduce undesirable side-effects. Nanoparticles (NPs) allow for the design of ligand-coated materials that can fulfil this function but have not yet shown consistent clinical results to make the ‘magic bullet’ theory a paradigm. The inconsistencies may be due to a range of biological factors like differences in disease models or expression levels of target receptor(s). NP design parameters could play a key role in alleviating these inconsistencies and significantly influence the therapeutic efficacy. To further improve this efficacy\, multi-ligand targeting strategies have been proposed\, however\, they remain controversial as they involve an intricate interplay between multitude of factors such as choice of ligands\, their receptor binding affinities\, NP surface densities\, stoichiometric ratios etc.\, thereby calling for a thorough understanding of the impact of these properties to improve their targeting potential. \nWithin this context\, we employ two cell targeting peptides (WQP and GE11) having different binding affinities to PSMA and EGFR receptors\, which are known PCa biomarkers. We evaluate the effect of multivalency of low affinity WQP peptide over its monomeric form on PSMA targeting. We find that by increasing the valency of WQP on NP surface\, we observe a higher cellular uptake of WQP-NPs over the monomeric form\, attributing to a stronger avidity. Next\, we assess the effect of two conjugation strategies using the high affinity GE11 peptide and study their impact on EGFR targeting in a systematic manner. We observe that conjugating GE11 peptide to PLGA-PEG polymer prior to NP formulation (pre-conjugation) allows for a higher and more controlled GE11 content on NP surface than conjugating it to formulated PLGA-PEG NPs (post-conjugation)\, consequently leading to a higher cellular uptake. \nBased on these findings\, we report a synthetic strategy for dual peptide-NPs with systematically varied properties\, specifically surface valencies and ratios\, and establish their impact on selective targeting in a prostate cancer (PCa) model. First\, we study the impact of peptide valencies on NP surface of dual NPs in comparison to single peptide-NPs on the selective cellular uptake in different PCa cell lines. Once we establish optimal surface valency\, we check the effect of different surface peptide ratios on cellular uptake and determine the optimal ratio for enhanced targeting of only those cells over-expressing both receptors\, by the virtue of improved selectivity. Somewhat counterintuitively\, we observe an increase in tumor cell uptake of NPs with lower peptide density\, which can be attributed to improved surface distribution of the peptide\, allowing for an enhanced availability to react with target receptor. This increase in uptake is a result of the two peptides acting in co-operation\, as opposed to simply an additive effect. Our findings demonstrate that through refined design and well-characterized NP formulations\, dual-peptide targeted nanosystems hold potential to provide precise cancer treatments. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220527T100000
DTEND;TZID=Europe/Madrid:20220527T120000
DTSTAMP:20260403T224657
CREATED:20220503T132210Z
LAST-MODIFIED:20220503T132210Z
UID:91656-1653645600-1653652800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Srivatsava Viswanadha Venkata Naga Sai and Madhura Murar
DESCRIPTION:Mechanical characterization of murine pluripotency dissolution\nSrivatsava Viswanadha Venkata Naga Sai\, Cellular and Molecular Mechanobiology Group \nMouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal\, mESCs exit naïve state and become functionally mature\, acquiring differentiation competence. From a mechanical point of view\, the instruction for initiating ground state exit is the integrin mediated mechano-sensing of extra cellular matrix (ECM). Although laminin has been found to be the pivotal ECM ligand for pluripotency dissolution\, the down-stream mechano-responses accompanying its sensing\, their spatio-temporal evolution and\, their regulatory role in mESC maturation remain unclear. In this work\, we combine mechanical measurements\, functional characterization\, and live cell imaging to unravel the role of mESCs-ECM interactions during naïve state exit and pluripotency dissolution. We employ a Rex1::GFPd2 expressing mESC line to monitor naïve state exit in real time\, combined with a laminin-rich ECM environment. During naïve state exit\, we observe a progressive increase in cell-ECM interaction\, marked by an increase in traction forces\, growth of focal adhesions\, and the reorganization of the basal actin from a mesh-like network into an oriented filamentous morphology reminiscent of stress fibres. Furthermore\, inhibition of non-muscle myosin-II using blebbistatin significantly delayed naïve state exit\, suggesting a regulatory role of cell contractility in mESC maturation. We finally investigate the role of these changes in cell-ECM interactions in mediating nuclear mechanoresponses\, and their influence in mESC pluripotency dissolution. \n\n\nDual peptide-mediated design of polymeric nanoparticles: towards precision prostate cancer targeting\nMadhura Murar\, Nanoscopy for Nanomedicine Group \nA key bottleneck of current cancer treatments is the lack of selective targeting of cancer cells to reduce undesirable side-effects. Nanoparticles (NPs) allow for the design of ligand-coated materials that can fulfil this function but have not yet shown consistent clinical results to make the ‘magic bullet’ theory a paradigm. The inconsistencies may be due to a range of biological factors like differences in disease models or expression levels of target receptor(s). NP design parameters could play a key role in alleviating these inconsistencies and significantly influence the therapeutic efficacy. To further improve this efficacy\, multi-ligand targeting strategies have been proposed\, however\, they remain controversial as they involve an intricate interplay between multitude of factors such as choice of ligands\, their receptor binding affinities\, NP surface densities\, stoichiometric ratios etc.\, thereby calling for a thorough understanding of the impact of these properties to improve their targeting potential. \nWithin this context\, we employ two cell targeting peptides (WQP and GE11) having different binding affinities to PSMA and EGFR receptors\, which are known PCa biomarkers. We evaluate the effect of multivalency of low affinity WQP peptide over its monomeric form on PSMA targeting. We find that by increasing the valency of WQP on NP surface\, we observe a higher cellular uptake of WQP-NPs over the monomeric form\, attributing to a stronger avidity. Next\, we assess the effect of two conjugation strategies using the high affinity GE11 peptide and study their impact on EGFR targeting in a systematic manner. We observe that conjugating GE11 peptide to PLGA-PEG polymer prior to NP formulation (pre-conjugation) allows for a higher and more controlled GE11 content on NP surface than conjugating it to formulated PLGA-PEG NPs (post-conjugation)\, consequently leading to a higher cellular uptake. \nBased on these findings\, we report a synthetic strategy for dual peptide-NPs with systematically varied properties\, specifically surface valencies and ratios\, and establish their impact on selective targeting in a prostate cancer (PCa) model. First\, we study the impact of peptide valencies on NP surface of dual NPs in comparison to single peptide-NPs on the selective cellular uptake in different PCa cell lines. Once we establish optimal surface valency\, we check the effect of different surface peptide ratios on cellular uptake and determine the optimal ratio for enhanced targeting of only those cells over-expressing both receptors\, by the virtue of improved selectivity. Somewhat counterintuitively\, we observe an increase in tumor cell uptake of NPs with lower peptide density\, which can be attributed to improved surface distribution of the peptide\, allowing for an enhanced availability to react with target receptor. This increase in uptake is a result of the two peptides acting in co-operation\, as opposed to simply an additive effect. Our findings demonstrate that through refined design and well-characterized NP formulations\, dual-peptide targeted nanosystems hold potential to provide precise cancer treatments. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220527T100000
DTEND;TZID=Europe/Madrid:20220527T120000
DTSTAMP:20260403T224657
CREATED:20220503T132210Z
LAST-MODIFIED:20220503T132210Z
UID:96601-1653645600-1653652800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Srivatsava Viswanadha Venkata Naga Sai and Madhura Murar
DESCRIPTION:Mechanical characterization of murine pluripotency dissolution\nSrivatsava Viswanadha Venkata Naga Sai\, Cellular and Molecular Mechanobiology Group \nMouse Embryonic Stem Cells (mESCs) can be maintained in ground/naïve state when grown in a defined N2B27 media with the supplementation of two inhibitors (2i) for MEK/Erk and GSK3β. Upon 2i withdrawal\, mESCs exit naïve state and become functionally mature\, acquiring differentiation competence. From a mechanical point of view\, the instruction for initiating ground state exit is the integrin mediated mechano-sensing of extra cellular matrix (ECM). Although laminin has been found to be the pivotal ECM ligand for pluripotency dissolution\, the down-stream mechano-responses accompanying its sensing\, their spatio-temporal evolution and\, their regulatory role in mESC maturation remain unclear. In this work\, we combine mechanical measurements\, functional characterization\, and live cell imaging to unravel the role of mESCs-ECM interactions during naïve state exit and pluripotency dissolution. We employ a Rex1::GFPd2 expressing mESC line to monitor naïve state exit in real time\, combined with a laminin-rich ECM environment. During naïve state exit\, we observe a progressive increase in cell-ECM interaction\, marked by an increase in traction forces\, growth of focal adhesions\, and the reorganization of the basal actin from a mesh-like network into an oriented filamentous morphology reminiscent of stress fibres. Furthermore\, inhibition of non-muscle myosin-II using blebbistatin significantly delayed naïve state exit\, suggesting a regulatory role of cell contractility in mESC maturation. We finally investigate the role of these changes in cell-ECM interactions in mediating nuclear mechanoresponses\, and their influence in mESC pluripotency dissolution. \n\n\nDual peptide-mediated design of polymeric nanoparticles: towards precision prostate cancer targeting\nMadhura Murar\, Nanoscopy for Nanomedicine Group \nA key bottleneck of current cancer treatments is the lack of selective targeting of cancer cells to reduce undesirable side-effects. Nanoparticles (NPs) allow for the design of ligand-coated materials that can fulfil this function but have not yet shown consistent clinical results to make the ‘magic bullet’ theory a paradigm. The inconsistencies may be due to a range of biological factors like differences in disease models or expression levels of target receptor(s). NP design parameters could play a key role in alleviating these inconsistencies and significantly influence the therapeutic efficacy. To further improve this efficacy\, multi-ligand targeting strategies have been proposed\, however\, they remain controversial as they involve an intricate interplay between multitude of factors such as choice of ligands\, their receptor binding affinities\, NP surface densities\, stoichiometric ratios etc.\, thereby calling for a thorough understanding of the impact of these properties to improve their targeting potential. \nWithin this context\, we employ two cell targeting peptides (WQP and GE11) having different binding affinities to PSMA and EGFR receptors\, which are known PCa biomarkers. We evaluate the effect of multivalency of low affinity WQP peptide over its monomeric form on PSMA targeting. We find that by increasing the valency of WQP on NP surface\, we observe a higher cellular uptake of WQP-NPs over the monomeric form\, attributing to a stronger avidity. Next\, we assess the effect of two conjugation strategies using the high affinity GE11 peptide and study their impact on EGFR targeting in a systematic manner. We observe that conjugating GE11 peptide to PLGA-PEG polymer prior to NP formulation (pre-conjugation) allows for a higher and more controlled GE11 content on NP surface than conjugating it to formulated PLGA-PEG NPs (post-conjugation)\, consequently leading to a higher cellular uptake. \nBased on these findings\, we report a synthetic strategy for dual peptide-NPs with systematically varied properties\, specifically surface valencies and ratios\, and establish their impact on selective targeting in a prostate cancer (PCa) model. First\, we study the impact of peptide valencies on NP surface of dual NPs in comparison to single peptide-NPs on the selective cellular uptake in different PCa cell lines. Once we establish optimal surface valency\, we check the effect of different surface peptide ratios on cellular uptake and determine the optimal ratio for enhanced targeting of only those cells over-expressing both receptors\, by the virtue of improved selectivity. Somewhat counterintuitively\, we observe an increase in tumor cell uptake of NPs with lower peptide density\, which can be attributed to improved surface distribution of the peptide\, allowing for an enhanced availability to react with target receptor. This increase in uptake is a result of the two peptides acting in co-operation\, as opposed to simply an additive effect. Our findings demonstrate that through refined design and well-characterized NP formulations\, dual-peptide targeted nanosystems hold potential to provide precise cancer treatments. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220607T150000
DTEND;TZID=Europe/Madrid:20220607T170000
DTSTAMP:20260403T224657
CREATED:20220513T065850Z
LAST-MODIFIED:20220513T065850Z
UID:91743-1654614000-1654621200@ibecbarcelona.eu
SUMMARY:Meet the editors: Christine Horejs and Kristy Hooper
DESCRIPTION:Come and meet the editors of Nature Reviews Bioengineering and The Company of Biologists: Christine Horejs and Kirsty Hooper. In this seminar we will hear about the latest updates in their journals and we will discuss the future of scholarly publishing and the open access models. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/meet-the-editors-christine-horejs-and-kristy-hooper/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220607T150000
DTEND;TZID=Europe/Madrid:20220607T170000
DTSTAMP:20260403T224657
CREATED:20220513T065850Z
LAST-MODIFIED:20220513T065850Z
UID:96621-1654614000-1654621200@ibecbarcelona.eu
SUMMARY:Meet the editors: Christine Horejs and Kristy Hooper
DESCRIPTION:Come and meet the editors of Nature Reviews Bioengineering and The Company of Biologists: Christine Horejs and Kirsty Hooper. In this seminar we will hear about the latest updates in their journals and we will discuss the future of scholarly publishing and the open access models. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/meet-the-editors-christine-horejs-and-kristy-hooper-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220607T150000
DTEND;TZID=Europe/Madrid:20220607T170000
DTSTAMP:20260403T224657
CREATED:20220513T065850Z
LAST-MODIFIED:20220513T065850Z
UID:96623-1654614000-1654621200@ibecbarcelona.eu
SUMMARY:Meet the editors: Christine Horejs and Kristy Hooper
DESCRIPTION:Come and meet the editors of Nature Reviews Bioengineering and The Company of Biologists: Christine Horejs and Kirsty Hooper. In this seminar we will hear about the latest updates in their journals and we will discuss the future of scholarly publishing and the open access models. \n  \nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/meet-the-editors-christine-horejs-and-kristy-hooper-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T110000
DTEND;TZID=Europe/Madrid:20220610T130000
DTSTAMP:20260403T224658
CREATED:20220517T135357Z
LAST-MODIFIED:20220517T135357Z
UID:96630-1654858800-1654866000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gerard Rubí Sans
DESCRIPTION:Development of an in vitro three-dimensional colorectal cancer model using cell-derived extracellular matrices\nAuthor: Gerard Rubí Sans\nDirectors: Dra. Elisabet Engel López and Dr. Miguel Ángel Mateos Timoneda \nThis thesis defence will take place at “Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)” at 11AM. \nIf you wish to follow this defence online\, you can do it through Google Meet here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gerard-rubi-sans-3/
LOCATION:Careers at IBEC
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T110000
DTEND;TZID=Europe/Madrid:20220610T130000
DTSTAMP:20260403T224658
CREATED:20220517T135357Z
LAST-MODIFIED:20220517T135357Z
UID:96628-1654858800-1654866000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gerard Rubí Sans
DESCRIPTION:Development of an in vitro three-dimensional colorectal cancer model using cell-derived extracellular matrices\nAuthor: Gerard Rubí Sans\nDirectors: Dra. Elisabet Engel López and Dr. Miguel Ángel Mateos Timoneda \nThis thesis defence will take place at “Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)” at 11AM. \nIf you wish to follow this defence online\, you can do it through Google Meet here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gerard-rubi-sans-2/
LOCATION:Careers at IBEC
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220610T110000
DTEND;TZID=Europe/Madrid:20220610T130000
DTSTAMP:20260403T224658
CREATED:20220517T135357Z
LAST-MODIFIED:20220517T135357Z
UID:96625-1654858800-1654866000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gerard Rubí Sans
DESCRIPTION:Development of an in vitro three-dimensional colorectal cancer model using cell-derived extracellular matrices\nAuthor: Gerard Rubí Sans\nDirectors: Dra. Elisabet Engel López and Dr. Miguel Ángel Mateos Timoneda \nThis thesis defence will take place at “Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)” at 11AM. \nIf you wish to follow this defence online\, you can do it through Google Meet here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gerard-rubi-sans/
LOCATION:Careers at IBEC
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220617T083000
DTEND;TZID=Europe/Madrid:20220619T140000
DTSTAMP:20260403T224658
CREATED:20211025T144511Z
LAST-MODIFIED:20220614T182638Z
UID:88045-1655454600-1655647200@ibecbarcelona.eu
SUMMARY:EMBL-IBEC Winter Conference Engineering Multicellular Systems
DESCRIPTION:EMBL and IBEC aim to contribute to the discussion on challenges and opportunities in the expanding field of engineered multicellular systems\n \nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos. \nThis biennial series of will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \nThe 2nd edition conference will take place in PRBB Auditorium (Barcelona Biomedical Research Park)\, in Barcelona from 9-11th February 2022. We expect to bring together 150 researchers including stem cell biologists\, systems biologists\, physicists and engineers. \nIMPORTANT DEADLINES\n\nAbstract submission deadline: 15/11/2021\nNotification of acceptance: 30/11/2021\nEarly registration: 30/12/2021\nLate registration: 30/01/2022 \nAbstract submission here \nRegistration here \n#EIWC22
URL:https://ibecbarcelona.eu/event/embl-ibec-winter-conference-engineering-multicellular-systems/
LOCATION:Barcelona Biomedical Research Park (PRBB)\, Dr. Aiguader 88 \, Barcelona\, 08003
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T100000
DTEND;TZID=Europe/Madrid:20220627T140000
DTSTAMP:20260403T224658
CREATED:20220623T110756Z
LAST-MODIFIED:20220623T110756Z
UID:96631-1656324000-1656338400@ibecbarcelona.eu
SUMMARY:Biomedical signal interpretation and smartphone sensors for the assessment of trunk function and sleep disorders in patients with spinal cord injury
DESCRIPTION:Author: Yolanda Castillo\nGroup: Biomedical Signal Processing and Interpretation\nDirectors: Raimon Jané \n  \nAbstract:\nSpinal cord injury (SCI) is one of the leading causes of disability worldwide. SCI causes motor and sensory impairment below the level of the injury\, but it is also associated with many other health complications. Two of these problems are trunk muscle impairment and sleep disorders. Impaired trunk function affects postural control and sitting balance\, which are critical for activities of daily living. Disturbed sleep causes fatigue and sleepiness and can lead to serious comorbidities\, impacting patient recovery and outcomes. However\, due to the multiple health problems secondary to SCI and the limitations in current diagnostic tools\, trunk function and sleep are rarely examined after SCI. The non-invasive acquisition and analysis of biomedical signals can help to overcome this issue\, providing quantitative measures to assess patient condition. Smartphones can facilitate this task\, thanks to their ubiquitous presence and powerful sensors.\n\n\nThe aim of this PhD thesis is to propose new smartphone-based tools and biomedical signal analysis techniques for the quantitative assessment of trunk function and sleep-disordered breathing (SDB) in patients with SCI.  This thesis is divided into two parts\, including four publications in high-impact journals. The first part addresses the characterization of trunk function in healthy subjects and patients with cervical (cSCI) and thoracic SCI (tSCI). The second part focuses on the development of a mobile health (mHealth) system based on smartphone audio signals for obstructive sleep apnea (OSA) diagnosis\, and the detection and monitoring of SDB in SCI patients.\n\nThe first part of the thesis introduces a novel methodology to quantitatively evaluate trunk function by combining electromyography (EMG) and smartphone accelerometry. In the first study\, we characterized the muscle activity and movement patterns of trunk flexion during reaching in healthy humans and investigated if trunk stability was affected by a startling acoustic stimulus (SAS). We found that SAS markedly reduced the response time (RespT) and EMG onset latencies of all muscles (the so-called StartReact effect)\, either prime movers or stabilizers. In the second study\, we evaluated trunk function and the effects of a SAS in patients with cSCI and tSCI. The results revealed deficits in postural control and compensatory strategies employed by SCI patients\, such as delayed responses and high lateral deviations\, with potential consequences for rehabilitation. This was the first study investigating the StartReact responses in trunk muscles in SCI. The SAS significantly shortened the RespT in tSCI\, but not in cSCI\, which suggests an increased cortical control in cSCI.\n\nIn the second part of the thesis\, we present mHealth tools for monitoring sleep disorders and investigate the sleep patterns of SCI patients. In the first article of this part\, we designed a smartphone system and novel algorithms based on acoustic analysis for OSA screening. This approach demonstrated good agreement with a commercial system for home OSA diagnosis\, correctly detecting and stratifying all the OSA patients. In the last article\, sleep studies were performed in SCI patients using the smartphone\, showing a very high prevalence of moderate-to-severe SDB in SCI patients. This study highlighted the problem of SDB in SCI and provided simple cost-effective tools to improve the detection and management of SDB in SCI patients.\n\nOverall\, this thesis supports the use of smartphones and biomedical signal analysis for the assessment of trunk function and SDB in SCI patients. These novel approaches provide quantitative and objective measures for the evaluation and follow-up of patients in a simple and non-invasive way. We also give insights into the underlying mechanisms of postural control\, respiratory function during sleep\, and the changes occurring after SCI. Consequently\, our results open the way for improving the management of health complications associated with SCI or other disabling conditions.\n\n\n\n\n\nThis thesis defence will take place at: Sala d’Actes de l’Escola d’Enginyeria Barcelona Est (EEBE)\, Edifici A\, planta 0\, Campus Diagonal-Besòs de la UPC\, Av. d’Eduard Maristany\, 16\, 08019 Barcelona. \nIf you wish to follow this defence online\, you can do it through this link: meet.google.com/roe-omfr-sse
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-yolanda-castillo
LOCATION:Sala d’Actes EEBE\, Edifici A\,\, Av. Eduard Maristany 16\, 08019 Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T100000
DTEND;TZID=Europe/Madrid:20220627T140000
DTSTAMP:20260403T224658
CREATED:20220623T110756Z
LAST-MODIFIED:20220623T110756Z
UID:96636-1656324000-1656338400@ibecbarcelona.eu
SUMMARY:Biomedical signal interpretation and smartphone sensors for the assessment of trunk function and sleep disorders in patients with spinal cord injury
DESCRIPTION:Author: Yolanda del Castillo\nGroup: Biomedical Signal Processing and Interpretation\nDirectors: Raimon Jané \n  \nAbstract:\nSpinal cord injury (SCI) is one of the leading causes of disability worldwide. SCI causes motor and sensory impairment below the level of the injury\, but it is also associated with many other health complications. Two of these problems are trunk muscle impairment and sleep disorders. Impaired trunk function affects postural control and sitting balance\, which are critical for activities of daily living. Disturbed sleep causes fatigue and sleepiness and can lead to serious comorbidities\, impacting patient recovery and outcomes. However\, due to the multiple health problems secondary to SCI and the limitations in current diagnostic tools\, trunk function and sleep are rarely examined after SCI. The non-invasive acquisition and analysis of biomedical signals can help to overcome this issue\, providing quantitative measures to assess patient condition. Smartphones can facilitate this task\, thanks to their ubiquitous presence and powerful sensors.\n\n\nThe aim of this PhD thesis is to propose new smartphone-based tools and biomedical signal analysis techniques for the quantitative assessment of trunk function and sleep-disordered breathing (SDB) in patients with SCI.  This thesis is divided into two parts\, including four publications in high-impact journals. The first part addresses the characterization of trunk function in healthy subjects and patients with cervical (cSCI) and thoracic SCI (tSCI). The second part focuses on the development of a mobile health (mHealth) system based on smartphone audio signals for obstructive sleep apnea (OSA) diagnosis\, and the detection and monitoring of SDB in SCI patients.\n\nThe first part of the thesis introduces a novel methodology to quantitatively evaluate trunk function by combining electromyography (EMG) and smartphone accelerometry. In the first study\, we characterized the muscle activity and movement patterns of trunk flexion during reaching in healthy humans and investigated if trunk stability was affected by a startling acoustic stimulus (SAS). We found that SAS markedly reduced the response time (RespT) and EMG onset latencies of all muscles (the so-called StartReact effect)\, either prime movers or stabilizers. In the second study\, we evaluated trunk function and the effects of a SAS in patients with cSCI and tSCI. The results revealed deficits in postural control and compensatory strategies employed by SCI patients\, such as delayed responses and high lateral deviations\, with potential consequences for rehabilitation. This was the first study investigating the StartReact responses in trunk muscles in SCI. The SAS significantly shortened the RespT in tSCI\, but not in cSCI\, which suggests an increased cortical control in cSCI.\n\nIn the second part of the thesis\, we present mHealth tools for monitoring sleep disorders and investigate the sleep patterns of SCI patients. In the first article of this part\, we designed a smartphone system and novel algorithms based on acoustic analysis for OSA screening. This approach demonstrated good agreement with a commercial system for home OSA diagnosis\, correctly detecting and stratifying all the OSA patients. In the last article\, sleep studies were performed in SCI patients using the smartphone\, showing a very high prevalence of moderate-to-severe SDB in SCI patients. This study highlighted the problem of SDB in SCI and provided simple cost-effective tools to improve the detection and management of SDB in SCI patients.\nOverall\, this thesis supports the use of smartphones and biomedical signal analysis for the assessment of trunk function and SDB in SCI patients. These novel approaches provide quantitative and objective measures for the evaluation and follow-up of patients in a simple and non-invasive way. We also give insights into the underlying mechanisms of postural control\, respiratory function during sleep\, and the changes occurring after SCI. Consequently\, our results open the way for improving the management of health complications associated with SCI or other disabling conditions. \n\n\n\n\n\nThis thesis defence will take place at: Sala d’Actes de l’Escola d’Enginyeria Barcelona Est (EEBE)\, Edifici A\, planta 0\, Campus Diagonal-Besòs de la UPC\, Av. d’Eduard Maristany\, 16\, 08019 Barcelona. \nIf you wish to follow this defence online\, you can do it through this link: meet.google.com/roe-omfr-sse
URL:https://ibecbarcelona.eu/event/biomedical-signal-interpretation-and-smartphone-sensors-for-the-assessment-of-trunk-function-and-sleep-disorders-in-patients-with-spinal-cord-injury/
LOCATION:Sala d’Actes EEBE\, Edifici A\,\, Av. Eduard Maristany 16\, 08019 Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220627T123000
DTEND;TZID=Europe/Madrid:20220627T133000
DTSTAMP:20260403T224658
CREATED:20220627T070730Z
LAST-MODIFIED:20220627T070730Z
UID:96639-1656333000-1656336600@ibecbarcelona.eu
SUMMARY:Last minute Seminar: Laura Suter-Dick
DESCRIPTION:Liver and Kidney: 3D-in vitro systems for disease modelling and biomarker discovery\nProf. Laura Suter-Dick\nFHNW University of Applied Sciences and Arts Northwestern Switzerland School of Life Sciences\, Institute for Chemistry and Bioanalytics a Basel.
URL:https://ibecbarcelona.eu/event/last-minute-seminar-laura-suter-dick/
LOCATION:Sala Baobab\, Tower I - 11th floor
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220701T090000
DTEND;TZID=Europe/Madrid:20220701T174500
DTSTAMP:20260403T224658
CREATED:20220623T112616Z
LAST-MODIFIED:20220623T112616Z
UID:96633-1656666000-1656697500@ibecbarcelona.eu
SUMMARY:THERACAT Conference
DESCRIPTION:Bio-orthogonal catalysis for cancer therapy (THERACAT)\n\n\nTHERACAT is a Marie Skłodowska-Curie European Training Network (MSCA-ITN-ETN) aiming to train a new generation of researchers on the innovative topic of bio-orthogonal catalysis for cancer therapy \nThe development of novel cancer therapies is a major challenge for academic research and pharmaceutical industries. Although the recent progress in traditional treatments such as surgery and chemotherapy improved the clinical outcome of cancer patients\, there is a strong need for new and effective approaches as well as for a new generation of young scientists trained to tackle these challenges from a multidisciplinary perspective. THERACAT establishes an international training programme focused on the development of catalysis-based approaches towards the cure of cancer. In this strategy nano- and micro-particles bearing a catalytic unit are delivered to the tumour site and subsequently non-active prodrugs are administered to the patient. The prodrugs are non-toxic and therefore generate limited side effects. Only at the tumour site the catalytic particles convert the prodrugs into active anticancer compounds that generate a local and strong effect\, as single catalytic species can uncage a large number of drugs. This approach presents several advantages on the classical drug delivery paradigm including limited side effects and prolonged efficacy. \nThe final aim of the THERACAT network is to consolidate Europe as the world leader in novel catalysis-based approach for cancer therapy. \n 
URL:https://ibecbarcelona.eu/event/theracat-conference/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220715T100000
DTEND;TZID=Europe/Madrid:20220715T120000
DTSTAMP:20260403T224658
CREATED:20220503T132602Z
LAST-MODIFIED:20220503T132602Z
UID:96603-1657879200-1657886400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Marc Azagra and Inês Sousa
DESCRIPTION:Novel Nuclear Magnetic Resonance (NMR) applications in the clinical field\nMarc Azagra\, Molecular Imaging for Precision Medicine Group \nWhen nuclear magnetic resonance (NMR) was described more than half a century ago it appeared to be a curiosity of the quantum world. Since then NMR spectroscopy has become an essential tool not only for chemists\, but also for biochemists\, molecular biologists and even clinicians. Today we are going to explain what is Hyperpolarization NMR\, main differences with thermal NMR acquisitions and two of the projects I am involved with: a new NMR application in clinical diagnosis stage for Liver disease and the first experiment ever performed with High-throughput Hyperpolarized Magnetic Resonance Imaging experiment with a multiwell microfluidic chips using Chemical Shift Imaging (CSI) pulse sequence. \n\n\nVersatile gelatine-based biomaterials compatible with neuronal differentiation: Applications in different systems for brain modelling\nInês Sousa Pereira\, Nanobioengineering Group \nTissue engineering has been focused on recreating the tissue environment of many organs\, such as the brain\, for modelling and for therapeutic approaches during the last years. Recently\, 3D brain in vitro models have been explored as they resemble more accurately physiological conditions of this organ. However\, neuronal cultures are challenging due to the high sensitivity of these cells to changes in their surroundings. \nWe present a hydrogel composed of methacrylated gelatine (GeIMA)\, alginate (AlgMA) and hyaluronic acid (HA) for neural progenitor cell culture in this work. Our goal was to assess the compatibility of GelMA and AlgMA composites with neuronal culture as these two materials are common in tissue engineering applications. HA was added to better mimic the stiffness of the brain tissue. Neuroprogenitor mouse cell line C17.2 was embedded in the gelatine-based formulations and cultured as 3D scaffold in a drop shape or inserted in a microfluidic device. They were also used as bioinks for extrusion bioprinting. We performed the physical characterization of both formulations\, viability studies\, immunostainings to assess the differentiation process and calcium imaging to validate the activity of the cells. \nResults show that hydrogels with and without hyaluronic acid have good porosity\, allowing nutrient and oxygen diffusion. They also present low Young Modulus\, especially for hyaluronic acid formulation\, rendering values similar to the brain tissue.\, the viability of the cells as well as the cell differentiation and connectivity were high after 28 days in culture In the assays with the formulations as scaffolds. The activity of the cells was assessed at day 8 and increased by day 15 for both formulations\, showing that cells were differentiating\, and the neuronal network was maturating. In the bioprinting assays\, the formulations presented high cell viability up to 15 days after printing and day 15 immunostaining showed the expression of neuroprogenitor marker nestin and early neuron marker β-III tubulin. On 3D-brain on the chip assays\, the both formulations had high cell viability up until day 15 of culture\, increasing expression of β-III tubulin as well as cell activity. \nIn conclusion\, our formulations allow long-term cell culture\, including high expression of neuronal markers\, cell connectivity and activity and the presence of HA gave the hydrogel physical characteristics closer to brain tissue while permitting a high cell viability and allowing the differentiation of C17.2 cells. These biomaterials are also suitable as bioinks for extrusion in a bioprinter as proven by the good viability of the cells and the compatibility with the differentiation process. The formulations were also tested in a microfluidic system\, maintaining the viability\, differentiation\, and activity capacities of the cells. Overall\, these results make these hydrogels a promising scaffold for brain modelling\, applicable to 3D long-term culture and differentiation of cells\, such as iPSC-derived neurons. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220715T100000
DTEND;TZID=Europe/Madrid:20220715T120000
DTSTAMP:20260403T224658
CREATED:20220503T132602Z
LAST-MODIFIED:20220503T132602Z
UID:91660-1657879200-1657886400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Marc Azagra and Inês Sousa
DESCRIPTION:Novel Nuclear Magnetic Resonance (NMR) applications in the clinical field\nMarc Azagra\, Molecular Imaging for Precision Medicine Group \nWhen nuclear magnetic resonance (NMR) was described more than half a century ago it appeared to be a curiosity of the quantum world. Since then NMR spectroscopy has become an essential tool not only for chemists\, but also for biochemists\, molecular biologists and even clinicians. Today we are going to explain what is Hyperpolarization NMR\, main differences with thermal NMR acquisitions and two of the projects I am involved with: a new NMR application in clinical diagnosis stage for Liver disease and the first experiment ever performed with High-throughput Hyperpolarized Magnetic Resonance Imaging experiment with a multiwell microfluidic chips using Chemical Shift Imaging (CSI) pulse sequence. \n\n\nVersatile gelatine-based biomaterials compatible with neuronal differentiation: Applications in different systems for brain modelling\nInês Sousa Pereira\, Nanobioengineering Group \nTissue engineering has been focused on recreating the tissue environment of many organs\, such as the brain\, for modelling and for therapeutic approaches during the last years. Recently\, 3D brain in vitro models have been explored as they resemble more accurately physiological conditions of this organ. However\, neuronal cultures are challenging due to the high sensitivity of these cells to changes in their surroundings. \nWe present a hydrogel composed of methacrylated gelatine (GeIMA)\, alginate (AlgMA) and hyaluronic acid (HA) for neural progenitor cell culture in this work. Our goal was to assess the compatibility of GelMA and AlgMA composites with neuronal culture as these two materials are common in tissue engineering applications. HA was added to better mimic the stiffness of the brain tissue. Neuroprogenitor mouse cell line C17.2 was embedded in the gelatine-based formulations and cultured as 3D scaffold in a drop shape or inserted in a microfluidic device. They were also used as bioinks for extrusion bioprinting. We performed the physical characterization of both formulations\, viability studies\, immunostainings to assess the differentiation process and calcium imaging to validate the activity of the cells. \nResults show that hydrogels with and without hyaluronic acid have good porosity\, allowing nutrient and oxygen diffusion. They also present low Young Modulus\, especially for hyaluronic acid formulation\, rendering values similar to the brain tissue.\, the viability of the cells as well as the cell differentiation and connectivity were high after 28 days in culture In the assays with the formulations as scaffolds. The activity of the cells was assessed at day 8 and increased by day 15 for both formulations\, showing that cells were differentiating\, and the neuronal network was maturating. In the bioprinting assays\, the formulations presented high cell viability up to 15 days after printing and day 15 immunostaining showed the expression of neuroprogenitor marker nestin and early neuron marker β-III tubulin. On 3D-brain on the chip assays\, the both formulations had high cell viability up until day 15 of culture\, increasing expression of β-III tubulin as well as cell activity. \nIn conclusion\, our formulations allow long-term cell culture\, including high expression of neuronal markers\, cell connectivity and activity and the presence of HA gave the hydrogel physical characteristics closer to brain tissue while permitting a high cell viability and allowing the differentiation of C17.2 cells. These biomaterials are also suitable as bioinks for extrusion in a bioprinter as proven by the good viability of the cells and the compatibility with the differentiation process. The formulations were also tested in a microfluidic system\, maintaining the viability\, differentiation\, and activity capacities of the cells. Overall\, these results make these hydrogels a promising scaffold for brain modelling\, applicable to 3D long-term culture and differentiation of cells\, such as iPSC-derived neurons. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220722T080000
DTEND;TZID=Europe/Madrid:20220722T170000
DTSTAMP:20260403T224658
CREATED:20220722T093907Z
LAST-MODIFIED:20220722T094126Z
UID:97829-1658476800-1658509200@ibecbarcelona.eu
SUMMARY:2022 BIST Conference on Precision Medicine
DESCRIPTION:Precision Medicine: Putting discoveries to work\n\n\n\n\n\n\n\nThe Barcelona Institute of Science and Technology (BIST) is pleased to announce its 2022 BIST Conference to discuss the latest developments in an area of priority for BIST research\, this year focusing on Precision Medicine.The Conference will take place on November 10\, in the city of Barcelona. It will include keynote talks\, round-tables\, and selected flash-talks and posters on the topic of Precision Medicine. As in the past year\, the Conference will include satellite events.\n\n\n\nCall for abstractsThe main Conference session on November 10 will include selected 5-minute-long flash talks and a poster session on topics related to Precision Medicine. We invite you to submit your abstract though the form by September 10\, 2022.Instructions for abstract submission: \n\n\n\nPrepare your abstract in a word document to submit. The abstract should include: title\, authors with affiliations\, and a summary of maximum 250 words.During the abstract submission\, you will be asked to choose one of the following topics:DevicesGenetics and genomicsHigh-throughput technologiesModeling (e.g.: stem cells\, organoids\, systems biology)Non-invasive monitoring and imagingPrecision therapies (e.g.: CAR-T)Testing and biomarkers\n\n\n\nA public book of abstracts will be prepared for the Conference. \n\n\n\nYou can submit your abstract here. \n\n\n\nThere is no registration fee for this Conference. \n\n\n\nThe abstracts will be evaluated by the Conference Scientific Committee\, composed by Jorge Ferrer from CRG; Núria Montserrat and Irene Marco Rius from IBEC; Turgut Dururan from ICFO; José A. Garrido and Víctor Puntes from ICN2; and Patrick Aloy and Cayetano Gonzalez from IRB Barcelona.The 2022 BIST Conference\, and especially the Satellite Sessions\, are being prepared by the Organizing Committee\, formed by Gloria Lligadas from CRG; Anke Kleff from IBEC; Lydia Sanmartí from ICFO; Mónica H. Pérez-Temprano from ICIQ; Àlex Argemí from ICN2; and Zoila Babot\, Marta Llorens and Gabby Silberman from BIST.
URL:https://ibecbarcelona.eu/event/2022-bist-conference/
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220908T100000
DTEND;TZID=Europe/Madrid:20220908T130000
DTSTAMP:20260403T224658
CREATED:20220727T094315Z
LAST-MODIFIED:20220901T082701Z
UID:98246-1662631200-1662642000@ibecbarcelona.eu
SUMMARY:IBEC-IFIBYNE joint seminar
DESCRIPTION:10:00Institutional WelcomeJosep SamitierIBEC10:10Presentation by IFIBYNE directorAdali PecciIFIBYNE10:30Training-on-a-Chip: a multi-organ device to study the effect of muscle exercise on insulin secretion in vitroJavier RamónIBEC10:50Coffee Break11:20Genomic regulation in pancreatic beta cell development and regenerationSantiago RodríguezIFIBYNE11:40TBDRomén RodríguezIBEC12:00Closing\n\n\n\nThe seminar will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/ibec-ifibyne-joint-seminar/
LOCATION:Sala Baobab\, C/Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220909T100000
DTEND;TZID=Europe/Madrid:20220909T120000
DTSTAMP:20260403T224658
CREATED:20220829T080856Z
LAST-MODIFIED:20220829T081341Z
UID:98514-1662717600-1662724800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Myriam M. Chaumeil
DESCRIPTION:Imaging metabolism in neurological disorders\n\n\n\nAssociate Professor in Residence\, Departments of Physical Therapy and Rehabilitation Science & Radiology and Biomedical Imaging\, UCSFInvestigator\, Quantitative Bioscience Institutes (QBI)Lab website : Chaumeil Lab\, UCSF \n\n\n\nOur lab works on developing and biologically validating magnetic resonance (MR)-based metabolic imaging approaches using animal models of neurological diseases (such as genetically-engineered or toxin-induced). In this talk\, I will present how optimized acquisitions strategies\, based mostly on the hyperpolarized DNP-MR technology\, can be used for improved diagnosis and treatment monitoring of neurological diseases\, including multiple sclerosis\, chronic traumatic encephalopathy and Alzheimer’s disease. I will also show how we use metabolomics approaches to identify potential pathways modified in disease\, and normalized with treatment\, with an example focusing on interneuron transplantation as a treatment for epilepsy. \n\n\n\n\n\n\n\nDr. Chaumeil is an Associate Professor in Residence in the department of Physical Therapy & Rehabilitation Science and Radiology & Biomedical Imaging at UCSF\, a faculty member of three graduate programs (UCSF/UC Berkeley BioEngineering; UCSF Biomedical Science and UCSF Rehabilitation Science)\, and an investigator in the Quantitative Biosciences Institute. Her research focuses on developing new neuroimaging methods to improve the diagnosis and monitoring of neurological disorders\, such as Alzheimer’s disease\, Multiple Sclerosis or vascular dementia. She is a Junior Fellow of the International Society of Magnetic Resonance in Medicine\, and has been recently elected on the board of the ISMRM Hyperpolarized Study group. Dr. Chaumeil grew up in the south of France\, and received her engineer degree and her PhD degree in Paris\, before moving across the world to California to join UCSF. \n\n\n\n \n\n\n\nSala Baobab\, Tower I\, 11 Floor\, IBEC
URL:https://ibecbarcelona.eu/event/ibec-seminar-myriam-m-chaumeil/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220914T150000
DTEND;TZID=Europe/Madrid:20220914T170000
DTSTAMP:20260403T224658
CREATED:20220907T104718Z
LAST-MODIFIED:20220907T104744Z
UID:98985-1663167600-1663174800@ibecbarcelona.eu
SUMMARY:IBEC-IRB joint seminar
DESCRIPTION:Aberrant phase separation is a widespread killing mechanism of bioactive peptides in health and diseas\n\n\n\nSteven Boeynaems\, Assistant Professor at Baylor College of Medicine and Investigator at the Texas Children’s Hospital \n\n\n\nCationic repeat peptides are increasingly implicated in the pathophysiology of age-related neurodegenerative disease. These peptides are highly toxic in all tested disease models\, and seem to perturb an ever-expanding list of cellular pathways. This observation begs the question whether this target promiscuity is (1) relevant to disease and (2) how it is encoded in such simple sequences. A first clue came from the observation that these cationic repeat peptides have the tendency to drive protein condensation. Given their charge\, these peptides are exquisitely sensitive to the presence of nucleic acids. By studying their target space as a function of RNA concentration using mass spec\, we uncover a hidden hierarchy in their target preference that relates to subcellular differences in RNA abundance.  \n\n\n\nTo test whether these insights from disease translate to biology\, we used this framework to develop a machine learning algorithm that allowed us to predict protein behavior form sequence. Compellingly\, we uncover that bioactive peptides such as antimicrobial peptides produced by our own cells\, but also venom peptides derived from spiders\, scorpions and rattle snakes\, phenocopy the molecular behavior of these disease-related cationic peptides. In all\, we find that such peptides exert toxicity by upsetting the electrostatic balance of a cell\, hitting myriad pathways at once. We name this process polycation poisoning and find that it has independently evolved again and again across the entire tree of life as a killing strategy of bioactive peptides. Based on these findings we are now exploring toxin-antitoxin systems as innovative therapeutic strategies to protect neurons against cationic repeat peptide toxicity. \n\n\n\nHosts: Benedetta Bolognesi and Xavier Salvatella \n\n\n\nPlace: Felix Serratosa Hall\, PCB
URL:https://ibecbarcelona.eu/event/ibec-irb-joint-seminar/
LOCATION:Aula Félix Sarratosa\, PCB
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220916T120000
DTEND;TZID=Europe/Madrid:20220916T140000
DTSTAMP:20260403T224658
CREATED:20220909T111057Z
LAST-MODIFIED:20220914T075527Z
UID:99029-1663329600-1663336800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maximilian Loeck
DESCRIPTION:Comparative study of nanocarries targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes\n\n\n\nAuthor: Maximilian Loeck\, Targeted therapeutics and nanodevices \n\n\n\nThis thesis defence will take place at “Aula 14 (Dolors Aleu i Riera)\, Campus Clínic” at 12:30h. \nAddress: Facultad de Medicina\, Carrer de Casanova\, 143\, 08036 Barcelona
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maximilian-loeck/
LOCATION:Carrer de Casanova\, 143\, Campus Clínic\, Barcelona\, 08036
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220927
DTEND;VALUE=DATE:20220928
DTSTAMP:20260403T224658
CREATED:20220331T080224Z
LAST-MODIFIED:20220927T125023Z
UID:96579-1664236800-1664323199@ibecbarcelona.eu
SUMMARY:Mechanobiology of cancer summer school 2022
DESCRIPTION:The MECHANO·CONTROL consortium\, led by several research institutions across Europe\, is launching the second edition of the “Mechanobiology of Cancer” summer school\, which will take place between  September 27th –  October 1st at the Eco Resort in La Cerdanya. \n\n\n\n\n\n\n\n\n\n\n\n\nThe summer school aims to provide training on mechanobiology\, and specifically its application to cancer.This school will include lectures as well as practical workshops in different techniques and disciplines\, ranging from modeling to biomechanics to cancer biology. \nThere will be scientific sessions in the morning\, mixing 6 keynote speakers with short talks selected from abstract submissions by junior scientists attending the school and a poster session. In the afternoon\, there will be 2-3-hour practical workshops\, given by scientists from the MECHANO·CONTROL consortium. The course will also include leisure activities. \nThe 6 confirmed speakers who will attend the summer school are: \n\nDagmar Iber (ETH Zurich)\nHans Van Oosterwyck (KU Leuven)\nClaudia Fischbach (Director of Cornell’s Physical Sciences Oncology)\nGiorgio Scita (IFOM – The Firc Institute Of Molecular Oncology)\nMadeleine J. Oudin (Tufts University)\nMaria Celeste Aragona (University of Copenhagen)\n\nAttendance to the Summer School is open to all students\, post-docs\, and professionals interested\, although priority will be given to junior scientists (up to the post-doctoral stage). \n\nApplication deadline:9th May 2022 \nAcceptance and registration:17th June 2022
URL:https://ibecbarcelona.eu/event/mechanobiology-of-cancer-summer-school-2022/
CATEGORIES:External symposium / conference / congress,Other
ATTACH;FMTTYPE=image/png:https://ibecbarcelona.eu/wp-content/uploads/2022/03/595ec8f2-8b49-4c97-9cc7-17e8b603cb60.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220927T170000
DTEND;TZID=Europe/Madrid:20221001T093000
DTSTAMP:20260403T224658
CREATED:20220331T080224Z
LAST-MODIFIED:20220331T080224Z
UID:96577-1664298000-1664616600@ibecbarcelona.eu
SUMMARY:Mechanobiology of cancer summer school 2022
DESCRIPTION:The MECHANO·CONTROL consortium\, led by several research institutions across Europe\, is launching the second edition of the “Mechanobiology of Cancer” summer school\, which will take place between  September 27th –  October 1st at the Eco Resort in La Cerdanya. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nThe summer school aims to provide training on mechanobiology\, and specifically its application to cancer.\nThis school will include lectures as well as practical workshops in different techniques and disciplines\, ranging from modeling to biomechanics to cancer biology. \nThere will be scientific sessions in the morning\, mixing 6 keynote speakers with short talks selected from abstract submissions by junior scientists attending the school and a poster session. In the afternoon\, there will be 2-3-hour practical workshops\, given by scientists from the MECHANO·CONTROL consortium. The course will also include leisure activities. \nThe 6 confirmed speakers who will attend the summer school are: \n\nDagmar Iber (ETH Zurich)\nHans Van Oosterwyck (KU Leuven)\nClaudia Fischbach (Director of Cornell’s Physical Sciences Oncology)\nGiorgio Scita (IFOM – The Firc Institute Of Molecular Oncology)\nMadeleine J. Oudin (Tufts University)\nMaria Celeste Aragona (University of Copenhagen)\n\nAttendance to the Summer School is open to all students\, post-docs\, and professionals interested\, although priority will be given to junior scientists (up to the post-doctoral stage). \n\nApplication deadline:\n9th May 2022 \nAcceptance and registration:\n17th June 2022
URL:https://ibecbarcelona.eu/event/mechanobiology-of-cancer-summer-school-2022/
LOCATION:La Cerdanya Eco-Resort
CATEGORIES:External symposium / conference / congress
END:VEVENT
END:VCALENDAR