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SUMMARY:PhD Discussion: Aina Albajar and Ainhoa Gonzalez
DESCRIPTION:Studying the mechanical regulation of nucleocytoplasmic transport using Single Molecule Tracking\n\nAina Albajar-Sigalé\, Cellular and Molecular Mechanobiology Group \nCellular function relies on the precise regulation of macromolecular transport between the cytoplasm and the nucleus\, a process governed by Nuclear Pore Complexes (NPCs). While traditional understanding held that transport through NPCs was mainly dictated by the physicochemical properties of the transported molecules\, recent research has revealed an additional layer of regulation driven by mechanical forces. Whether applied directly or transmitted through the cytoskeleton\, mechanical signals have the capacity to deform the nucleus and\, consequently\, alter the conformation of NPCs\, increasing their diameter. This changes nucleocytoplasmic transport rates and impacts the localisation of a variety of signalling molecules. However\, the cellular components responsible for force transmission to NPCs as well as the spatial distribution of this effect throughout the nuclear envelope\, remain poorly understood. Here\, we aim to answer these questions by investigating whether isolated nuclei\, a minimal system depleted of all the cell’s cytoplasmic machinery\, still exhibit mechanosensitive nucleocytoplasmic transport. To do so\, we apply mechanical force by confining isolated nuclei to a certain micrometre height and\, simultaneously\, measure nucleocytoplasmic transport rates by tracking individual dextran molecules translocating through NPCs. Our results show that molecules translocate faster in confined nuclei\, suggesting that unspecific force application to a passive nuclear envelope is enough to induce conformational changes in NPCs and alter transport dynamics. \n  \n\nLaser-Induced Vapor Nanobubbles Trigger Immunogenic Cell Death Prophylactic Immunity in Bladder Cancer Models\n\nAinhoa G. Caelles\, Smart Nano-Bio-Devices Group \nBladder cancer (BC) is the 10th most common malignancy worldwide\, and despite treatments such as intravesical chemotherapy and Bacille Calmette-Guérin (BCG) immunotherapy\, high relapse rates persist\, especially in non-muscular invasive BC (NMIBC). Photothermal therapy (PTT) emerges as a promising non-invasive approach inducing tumor ablation while promoting immunogenic cell death (ICD). This project studies iron oxide nanoparticles (IONPs) as photosensitizers for laser-induced vapor nanobubbles (VNBs) in MB49 cells and its potential to induce cell death and prevent tumor relapse in subcutaneous/orthotopic murine models.
URL:https://ibecbarcelona.eu/event/phd-discussion-aina-albajar-and-ainhoa-gonzalez/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260529T080000
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CREATED:20260507T093943Z
LAST-MODIFIED:20260507T093943Z
UID:133565-1780041600-1780048800@ibecbarcelona.eu
SUMMARY:Ibec Seminar: Giorgio Volpe
DESCRIPTION:Steering Self-organization in Active Colloids and Droplets through Confinement\nConfinement\, whether externally imposed or generated by the system itself\, plays a central role in shaping the dynamics and self-organization of active matter. In natural systems\, such as microbial communities and social insects\, self-reinforced confinement is exploited to create functional structures and accomplish complex collective tasks. In contrast\, the potential of such mechanisms in synthetic active systems remains largely unexplored. In this talk\, I will present our recent work demonstrating how confinement can be harnessed as a generic design principle to program collective behaviour in active matter and non-equilibrium systems with applications in micro-robotics\, 4D printing\, and organic electronics.\n\nGiorgio Volpe is Professor of Soft Matter and group leader of the Soft Active Matter laboratory in the Department of Chemistry\, University College London. He obtained his PhD in Photonics at ICFO – The Institute of Photonic Sciences in Barcelona (Spain) in 2012. His current research focuses on studying the emergence of non-equilibrium phenomena in both biological and synthetic soft matter for applications in materials science and healthcare. To date\, he has published more than 50 peer-reviewed research articles and reviews in high-impact journals for the fields of active matter\, soft matter and photonics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-giorgio-volpe/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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