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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170116T120000
DTEND;TZID=Europe/Madrid:20170116T130000
DTSTAMP:20260405T194932
CREATED:20170111T111500Z
LAST-MODIFIED:20170111T111500Z
UID:95966-1484568000-1484571600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christian A. Nijhuis
DESCRIPTION:Molecular Diodes with Rectification Ratios of Nearly Six Orders of Magnitude\nChristian A. Nijhuis\, Department of Chemistry\, National University of Singapore\nOne of the major goals of molecular electronics is to relate the performance and electronic function of molecular devices to the chemical structure and intermolecular interactions of the organic molecules inside them. Molecular electronic devices are complex physical-organic systems that consist of at least two electrodes\, the organic component\, and two (different) organic/inorganic interfaces. Singling out the contribution of each of these components to the device performance is not straightforward. Besides\, fabrication of molecular junctions is still challenging and defects have to be minimized. \nDuring the talk\, I will discuss our recent progress of molecular diodes based on self-assembled monolayers (SAMs) of ferrocene-alkanethiolates of the form H(CH2)nFc (Fc = ferrocene) sandwiched between two electrodes. I will discuss in detail how we fabricate the junctions (using the well-characterized “EGaIn”-technique) and characterize our junctions and SAMs. We have investigated the various sources of defects in the junctions caused by the impurities in the SAM precursors\,[1] defects in the electrode material\,[2] or subtle changes to the electronic[3] and supramolecular structure of the junctions.[4] We used this accumulated knowledge to develop a well-performing diode that blocks the current in one direction of bias\, but allows it to pass through in the other\, with a difference of a factor of 6.3 x 105.[5\,6] \nWe hope that our findings will help to guide future experiments and to explain why some on paper promising diodes had disappointing performances.[7] \nReferences\n1) Jiang\, L.; Yuan\, L.; Cao\, L.; Nijhuis\, C. A. J. Am. Chem. Soc. 2014\, 136\, 1982.\n2) Yuan\, L.; jiang\, L.; Thompson\, D.; Nijhuis\, C. A. J. Am. Chem. Soc. 2014\, 136\, 6554.\n3) Yuan\, L.; Nerngchamnong\, N.; Cao\, L.; Hamoudi\, H.; Del Barco\, E.; Roemer\, M.; Sriramula\, R.; Thompson\, D.; Nijhuis\, C. A. Nat. Commun. 2015\, 6.\n4) Nerngchanmnong\, N.; Yuan\, L.; Qi\, D. C.; Jiang\, L.; Thompson\, D.; Nijhuis\, C. A. Nat. Nanotechnol. 2013\, 8\, 113.\n5) Yuan\, L.; Breuer\, R.; Jiang\, L.; Schmittel\, M.; Nijhuis\, C. A. Nano Lett. 2015\, 15\, 5506.\n6) Chen\, X.; Roemer\, M.; Yuan\, L.; Wei\, D.; Del Barco\, E.; Thompson\, D.; Nijhuis\, C.A. submitted\n7) Thompson\, D.; Nijhuis\, C. A. Acc. Chem. Res. 2016\, 49\, 2061
URL:https://ibecbarcelona.eu/event/ibec-seminar-christian-a-nijhuis-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161221T110000
DTEND;TZID=Europe/Madrid:20161221T130000
DTSTAMP:20260405T194932
CREATED:20161213T083928Z
LAST-MODIFIED:20161213T083928Z
UID:26434-1482318000-1482325200@ibecbarcelona.eu
SUMMARY:IBEC Thesis defense: Marc Van Der Hofstadt
DESCRIPTION:“Hygroscopic properties of single bacterial cells and endospores studied by Electrostatic Force Microscopy”\nMarc Van Der Hofstadt\, Nanoscale bioelectrical characterization group.\nMarc will be defending his PhD thesis on Wednesday 21st December at 11:00 at the Sala de Graus (Aulari)\, Facultat de Física (UB). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-thesis-defense-marc-van-der-hofstadt/
LOCATION:Sala de Graus Aulari\, Physics Faculty\, UB\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161221T110000
DTEND;TZID=Europe/Madrid:20161221T130000
DTSTAMP:20260405T194932
CREATED:20161213T083928Z
LAST-MODIFIED:20161213T083928Z
UID:95963-1482318000-1482325200@ibecbarcelona.eu
SUMMARY:IBEC Thesis defense: Marc Van Der Hofstadt
DESCRIPTION:“Hygroscopic properties of single bacterial cells and endospores studied by Electrostatic Force Microscopy”\nMarc Van Der Hofstadt\, Nanoscale bioelectrical characterization group.\nMarc will be defending his PhD thesis on Wednesday 21st December at 11:00 at the Sala de Graus (Aulari)\, Facultat de Física (UB). \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/ibec-thesis-defense-marc-van-der-hofstadt-2/
LOCATION:Sala de Graus Aulari\, Physics Faculty\, UB\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161220T190000
DTEND;TZID=Europe/Madrid:20161220T190000
DTSTAMP:20260405T194932
CREATED:20161128T082056Z
LAST-MODIFIED:20161128T082056Z
UID:95960-1482260400-1482260400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2016
DESCRIPTION:We’re delighted to invite you once again to the biggest\, best IBEC Christmas Party Ever!\nTuesday 20th December · Fifteen Restaurant\, PCB\n \nAs last year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWhen you register\, you’ll have a chance to choose one of the following charities to be a beneficiary of this fundraising: \nOption 1: Amics de la Gent Gran\nOption 2: Associació de Familiars i Amics de Nens Oncològics de Catalunya (AFANOC)\nOption 3: SETEM\nOption 4: Soñar Despierto \nChristmas party programme:\n18:30: Activity organised by the PhD Committee: Engineering BioChristmas\n20:00: Dinner and sale of raffle tickets\n22:00: Winning tickets and party\n00:30: End \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season! \nPlease register here (deadline 13th December). We’re counting on you to make the party go with a swing!
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2016-3/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161220T190000
DTEND;TZID=Europe/Madrid:20161220T190000
DTSTAMP:20260405T194932
CREATED:20161128T082056Z
LAST-MODIFIED:20161128T082056Z
UID:95961-1482260400-1482260400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2016
DESCRIPTION:More details coming soon – save the date!
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2016-2-2/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161220T190000
DTEND;TZID=Europe/Madrid:20161220T190000
DTSTAMP:20260405T194932
CREATED:20161128T082056Z
LAST-MODIFIED:20161212T091632Z
UID:26003-1482260400-1482260400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2016
DESCRIPTION:We’re delighted to invite you once again to the biggest\, best IBEC Christmas Party Ever!\nTuesday 20th December · Fifteen Restaurant\, PCB\n \nAs last year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWhen you register\, you’ll have a chance to choose one of the following charities to be a beneficiary of this fundraising: \nOption 1: Amics de la Gent Gran\nOption 2: Associació de Familiars i Amics de Nens Oncològics de Catalunya (AFANOC)\nOption 3: SETEM\nOption 4: Soñar Despierto \nChristmas party programme:\n18:30: Activity organised by the PhD Committee: Engineering BioChristmas\n20:00: Dinner and sale of raffle tickets\n22:00: Winning tickets and party\n00:30: End \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season! \nPlease register here (deadline 13th December). We’re counting on you to make the party go with a swing!
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2016/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161220T190000
DTEND;TZID=Europe/Madrid:20161220T190000
DTSTAMP:20260405T194932
CREATED:20161128T082056Z
LAST-MODIFIED:20161128T082056Z
UID:95959-1482260400-1482260400@ibecbarcelona.eu
SUMMARY:IBEC Christmas Party 2016
DESCRIPTION:We’re delighted to invite you once again to the biggest\, best IBEC Christmas Party Ever!\nTuesday 20th December · Fifteen Restaurant\, PCB\n \nAs last year\, there’ll be a chance to take part in a charity event to raise money for some very good causes. The more 1€ raffle tickets you buy during dinner\, the more likely you are to win one of the fabulous prizes provided by our sponsors. \nWhen you register\, you’ll have a chance to choose one of the following charities to be a beneficiary of this fundraising: \nOption 1: Amics de la Gent Gran\nOption 2: Associació de Familiars i Amics de Nens Oncològics de Catalunya (AFANOC)\nOption 3: SETEM\nOption 4: Soñar Despierto \nChristmas party programme:\n18:30: Activity organised by the PhD Committee: Engineering BioChristmas\n20:00: Dinner and sale of raffle tickets\n22:00: Winning tickets and party\n00:30: End \nWith all this\, plus food\, drink\, music and some fun surprises\, the IBEC Christmas Party promises once again to be a fabulous way to kick-start the festive season! \nPlease register here (deadline 13th December). We’re counting on you to make the party go with a swing!
URL:https://ibecbarcelona.eu/event/ibec-christmas-party-2016-2/
LOCATION:Fifteen Restaurant\, PCB
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161130T103000
DTEND;TZID=Europe/Madrid:20161130T140000
DTSTAMP:20260405T194932
CREATED:20161115T115117Z
LAST-MODIFIED:20161115T115117Z
UID:95949-1480501800-1480514400@ibecbarcelona.eu
SUMMARY:Advancing Gender Equality and Diversity in science
DESCRIPTION:IBEC is committed to awareness of diversity and gender equality in science and society. This follows our mission to carry out interdisciplinary research at the highest international quality level which\, by creating knowledge\, helps to improve health and quality of life\, and generate wealth. \nThis event will be a space for reflection and debate\, open to the public\, and involving experts from the field of gender and science. \n10:30am Registration\n11:00am David Badia (Introduction)\, Managing Director\, IBEC\n11:10am Montse Montllau\, Marketing and communications consultant (lecture in Catalan)\n11:40am Mara Dierssen\, Group Leader\, CRG\n12:10pm Jörg Müller\, Researcher\, Internet Interdisciplinary Institute (IN3-UOC). Gender & ICT\n12:30pm Carolina Marí\, Head of HR\, IBEC\n13:00pm Lluís Rovira (Closing remarks)\, Director\, CERCA\n13:20pm Time for questions and discussion\n13:35pm Networking and snacks \nTo register\, visit www.ibecbarcelona.eu/events/genderequality&diversity
URL:https://ibecbarcelona.eu/event/advancing-gender-equality-and-diversity-in-science-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161130T103000
DTEND;TZID=Europe/Madrid:20161130T140000
DTSTAMP:20260405T194932
CREATED:20161115T115117Z
LAST-MODIFIED:20161115T115117Z
UID:95950-1480501800-1480514400@ibecbarcelona.eu
SUMMARY:Advancing Gender Equality and Diversity in science
DESCRIPTION:IBEC is committed to awareness of diversity and gender equality in science and society. This follows our mission to carry out interdisciplinary research at the highest international quality level which\, by creating knowledge\, helps to improve health and quality of life\, and generate wealth. \nThis event will be a space for reflection and debate\, open to the public\, and involving experts from the field of gender and science. \n10:30am Registration\n11:00am David Badia (Introduction)\, Managing Director\, IBEC\n11:10am Montse Montllau\, Marketing and communications consultant (lecture in Catalan)\n11:40am Mara Dierssen\, Group Leader\, CRG\n12:10pm Jörg Müller\, Researcher\, Internet Interdisciplinary Institute (IN3-UOC). Gender & ICT\n12:30pm Carolina Marí\, Head of HR\, IBEC\n13:00pm Lluís Rovira (Closing remarks)\, Director\, CERCA\n13:20pm Time for questions and discussion\n13:35pm Networking and snacks \nTo register\, visit www.ibecbarcelona.eu/events/genderequality&diversity
URL:https://ibecbarcelona.eu/event/advancing-gender-equality-and-diversity-in-science-2-2/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161130T103000
DTEND;TZID=Europe/Madrid:20161130T140000
DTSTAMP:20260405T194933
CREATED:20161115T115117Z
LAST-MODIFIED:20161115T115117Z
UID:95951-1480501800-1480514400@ibecbarcelona.eu
SUMMARY:Advancing Gender Equality and Diversity in science
DESCRIPTION:IBEC is committed to awareness of diversity and gender equality in science and society. This follows our mission to carry out interdisciplinary research at the highest international quality level which\, by creating knowledge\, helps to improve health and quality of life\, and generate wealth. \nThis event will be a space for reflection and debate\, open to the public\, and involving experts from the field of gender and science. \n10:30am Registration\n11:00am David Badia (Introduction)\, Managing Director\, IBEC\n11:10am Montse Montllau\, Marketing and communications consultant (lecture in Catalan)\n11:40am Mara Dierssen\, Group Leader\, CRG\n12:10pm Jörg Müller\, Researcher\, Internet Interdisciplinary Institute (IN3-UOC). Gender & ICT\n12:30pm Carolina Marí\, Head of HR\, IBEC\n13:00pm Lluís Rovira (Closing remarks)\, Director\, CERCA\n13:20pm Time for questions and discussion\n13:35pm Networking and snacks \nTo register\, visit www.ibecbarcelona.eu/events/genderequality&diversity
URL:https://ibecbarcelona.eu/event/advancing-gender-equality-and-diversity-in-science-3/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161130T103000
DTEND;TZID=Europe/Madrid:20161130T140000
DTSTAMP:20260405T194933
CREATED:20161115T115117Z
LAST-MODIFIED:20170801T110535Z
UID:25877-1480501800-1480514400@ibecbarcelona.eu
SUMMARY:Advancing Gender Equality and Diversity in science
DESCRIPTION:IBEC is committed to awareness of diversity and gender equality in science and society. This follows our mission to carry out interdisciplinary research at the highest international quality level which\, by creating knowledge\, helps to improve health and quality of life\, and generate wealth. \nThis event will be a space for reflection and debate\, open to the public\, and involving experts from the field of gender and science. \n10:30am Registration\n11:00am David Badia (Introduction)\, Managing Director\, IBEC\n11:10am Montse Montllau\, Marketing and communications consultant (lecture in Catalan)\n11:40am Mara Dierssen\, Group Leader\, CRG\n12:10pm Jörg Müller\, Researcher\, Internet Interdisciplinary Institute (IN3-UOC). Gender & ICT\n12:30pm Carolina Marí\, Head of HR\, IBEC\n13:00pm Lluís Rovira (Closing remarks)\, Director\, CERCA\n13:20pm Time for questions and discussion\n13:35pm Networking and snacks \nTo register\, visit www.ibecbarcelona.eu/events/genderequality&diversity
URL:https://ibecbarcelona.eu/event/advancing-gender-equality-and-diversity-in-science/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Professional and Personal Development
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161125T100000
DTEND;TZID=Europe/Madrid:20161125T110000
DTSTAMP:20260405T194933
CREATED:20161116T155521Z
LAST-MODIFIED:20161116T155521Z
UID:95954-1480068000-1480071600@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Sessions: Jamish Parmar and Marta Pozuelo
DESCRIPTION:Title to follow\nJamish Parmar\, Smart nano-bio-devices group\nAbstract to follow \n  \nTitle to follow\nMarta Pozuelo\, Nanoprobes and nanoswitches group\nAbstract to follow
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-sessions-jamish-parmar-and-marta-pozuelo-3/
LOCATION:Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161125T100000
DTEND;TZID=Europe/Madrid:20161125T110000
DTSTAMP:20260405T194933
CREATED:20161116T155521Z
LAST-MODIFIED:20161116T155521Z
UID:95952-1480068000-1480071600@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Sessions: Gizem Altay and Marta Pozuelo
DESCRIPTION:Towards bioengineering a platform for the growth and differentiation of intestinal stem cells\nGizem Altay\, Biomimetic systems for cell engineering group\nIntestinal diseases affect major part of the world population; yet\, there is still the need of developing effective treatments. Animal models are widely used to study these diseases; however\, many intestinal processes are difficult to control in vivo. Besides these models are very costly and they raise ethical concerns. In vitro models\, on the other hand\, can enable improved studies in a well-controlled and ethical manner. The most advanced in vitro model reported up to date is the organoid system. Organoids are stem cell derived 3D self-organized tissue models that recapitulate many biological parameters of the native tissue such as the spatial organization\, multicellular hierarchy\, cell-matrix interactions and some physiological functions. Intestinal organoids contain crypt-villi domains with all major intestinal cell types and a central lumen region\, resembling many aspects of the intestine in vivo. However\, it is often difficult to control the stem cell differentiation and cell-matrix interactions within these systems. Besides\, the luminal compartment being inaccessible is a major inconvenience for studies such as drug absorption. These drawbacks raise the need to bioengineer a platform to obtain an intestinal epithelial model from intestinal stem cells.  \nIn the intestinal epithelium the stem cell growth and differentiation are controlled by biochemical gradients of the stemness factors. Moreover\, the 3D architecture and the mechanical properties of the native tissue are influential in the phenotype of these cells. Therefore\, in bioengineering the cellular microenvironment\, it is very important to reproduce the structural and mechanical characteristics of the native intestinal epithelium and to provide cells with the appropriate biochemical cues.\nIn this study we have developed 3D villus anatomical models from extracellular matrix like soft polyethylene glycol based hydrogels. The platform developed has controlled biochemical functionality and supports the intestinal stem cell attachment and growth. It is characterized to be able to create spatio-chemical gradients of the stemness factors to further modulate stem cell growth and differentiation. We have also developed a way to obtain 2D epithelial monolayers from intestinal crypts to further be implemented in the hydrogel based 3D villus models.   \n  \nStudying charge transport in Single-Protein wires\nMarta Pozuelo\, Nanoprobes and nanoswitches group\nElectron Transfer (ET) is undoubtedly one of the most important processes in life. Molecularly well-defined ET pathways in complex protein ensembles play a vital role in biological processes such as cell respiration or photosynthesis. The fundamental understanding of ET processes in biology is important not only to understand such key natural processes but also to advance in the design of biomolecule/electrode interfaces for Bioelectronic applications. The development of new techniques such as scanning probe microscopies (SPM) played a key role. In particular\, the electrochemical scanning tunneling microscopy (ECSTM) has been exploited to in situ monitor the ET rate as a function of the applied potential of individual metalloproteins immobilized on an Au electrode thanks to the single-molecule spatial resolution and the electrochemical gate capabilities. \nAzurin from Pseudomonas aeruginosa is a widely studied redox protein model both in bulk and at the single molecule level. Its globular structure contains a coordinated copper ion\, which makes the protein capable of exchanging electrons by switching its redox state (Cu I/II) and supports its role as a soluble electron carrier in the respiratory chain of bacteria. \nIn this contribution\, we will show our advances on the design and characterization of single-protein devices using a Cu-Azurin metalloprotein model. We have demonstrated transistor like-behaviour in an electrochemically-gated single-protein wire that operates at very low voltages thanks to the Cu-Azurin redox properties. It was demonstrated that the conductance varies depending on the redox state of the Cu centre\, having its maximum value at the redox-midpoint. We have also analysed the spontaneous formation of single-Azurin electrical contacts through the monitored current when the two ECSTM electrodes were placed at a fixed distance. Discrete switching events for the conductance were observed\, whose frequency depends on the applied electrochemical conditions and\, therefore\, they were univocally ascribed to discrete changes in the redox state of the trapped protein. \nIn order to tailor the charge transport behaviour of the single-protein wire\, we have synthesized several mutants of the protein by exploiting point-site bioengineering schemes at different positions of the protein second coordination sphere. Our results show that we can rationally change the transport mechanism of the single-protein device by studying the effect of the specific residue modification on the particular ET pathways in the protein backbone.
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-sessions-jamish-parmar-and-marta-pozuelo-2/
LOCATION:Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161125T100000
DTEND;TZID=Europe/Madrid:20161125T110000
DTSTAMP:20260405T194933
CREATED:20161116T155521Z
LAST-MODIFIED:20161122T171408Z
UID:25910-1480068000-1480071600@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Sessions: Gizem Altay and Marta Pozuelo
DESCRIPTION:Towards bioengineering a platform for the growth and differentiation of intestinal stem cells\nGizem Altay\, Biomimetic systems for cell engineering group\nIntestinal diseases affect major part of the world population; yet\, there is still the need of developing effective treatments. Animal models are widely used to study these diseases; however\, many intestinal processes are difficult to control in vivo. Besides these models are very costly and they raise ethical concerns. In vitro models\, on the other hand\, can enable improved studies in a well-controlled and ethical manner. The most advanced in vitro model reported up to date is the organoid system. Organoids are stem cell derived 3D self-organized tissue models that recapitulate many biological parameters of the native tissue such as the spatial organization\, multicellular hierarchy\, cell-matrix interactions and some physiological functions. Intestinal organoids contain crypt-villi domains with all major intestinal cell types and a central lumen region\, resembling many aspects of the intestine in vivo. However\, it is often difficult to control the stem cell differentiation and cell-matrix interactions within these systems. Besides\, the luminal compartment being inaccessible is a major inconvenience for studies such as drug absorption. These drawbacks raise the need to bioengineer a platform to obtain an intestinal epithelial model from intestinal stem cells.  \nIn the intestinal epithelium the stem cell growth and differentiation are controlled by biochemical gradients of the stemness factors. Moreover\, the 3D architecture and the mechanical properties of the native tissue are influential in the phenotype of these cells. Therefore\, in bioengineering the cellular microenvironment\, it is very important to reproduce the structural and mechanical characteristics of the native intestinal epithelium and to provide cells with the appropriate biochemical cues.\nIn this study we have developed 3D villus anatomical models from extracellular matrix like soft polyethylene glycol based hydrogels. The platform developed has controlled biochemical functionality and supports the intestinal stem cell attachment and growth. It is characterized to be able to create spatio-chemical gradients of the stemness factors to further modulate stem cell growth and differentiation. We have also developed a way to obtain 2D epithelial monolayers from intestinal crypts to further be implemented in the hydrogel based 3D villus models.   \n  \nStudying charge transport in Single-Protein wires\nMarta Pozuelo\, Nanoprobes and nanoswitches group\nElectron Transfer (ET) is undoubtedly one of the most important processes in life. Molecularly well-defined ET pathways in complex protein ensembles play a vital role in biological processes such as cell respiration or photosynthesis. The fundamental understanding of ET processes in biology is important not only to understand such key natural processes but also to advance in the design of biomolecule/electrode interfaces for Bioelectronic applications. The development of new techniques such as scanning probe microscopies (SPM) played a key role. In particular\, the electrochemical scanning tunneling microscopy (ECSTM) has been exploited to in situ monitor the ET rate as a function of the applied potential of individual metalloproteins immobilized on an Au electrode thanks to the single-molecule spatial resolution and the electrochemical gate capabilities. \nAzurin from Pseudomonas aeruginosa is a widely studied redox protein model both in bulk and at the single molecule level. Its globular structure contains a coordinated copper ion\, which makes the protein capable of exchanging electrons by switching its redox state (Cu I/II) and supports its role as a soluble electron carrier in the respiratory chain of bacteria. \nIn this contribution\, we will show our advances on the design and characterization of single-protein devices using a Cu-Azurin metalloprotein model. We have demonstrated transistor like-behaviour in an electrochemically-gated single-protein wire that operates at very low voltages thanks to the Cu-Azurin redox properties. It was demonstrated that the conductance varies depending on the redox state of the Cu centre\, having its maximum value at the redox-midpoint. We have also analysed the spontaneous formation of single-Azurin electrical contacts through the monitored current when the two ECSTM electrodes were placed at a fixed distance. Discrete switching events for the conductance were observed\, whose frequency depends on the applied electrochemical conditions and\, therefore\, they were univocally ascribed to discrete changes in the redox state of the trapped protein. \nIn order to tailor the charge transport behaviour of the single-protein wire\, we have synthesized several mutants of the protein by exploiting point-site bioengineering schemes at different positions of the protein second coordination sphere. Our results show that we can rationally change the transport mechanism of the single-protein device by studying the effect of the specific residue modification on the particular ET pathways in the protein backbone.
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-sessions-jamish-parmar-and-marta-pozuelo/
LOCATION:Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161125T100000
DTEND;TZID=Europe/Madrid:20161125T110000
DTSTAMP:20260405T194933
CREATED:20161116T155521Z
LAST-MODIFIED:20161116T155521Z
UID:95953-1480068000-1480071600@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Sessions: Jamish Parmar and Marta Pozuelo
DESCRIPTION:Title to follow\nJamish Parmar\, Smart nano-bio-devices group\nAbstract to follow \n  \nTitle to follow\nMarta Pozuelo\, Nanoprobes and nanoswitches group\nAbstract to follow
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-sessions-jamish-parmar-and-marta-pozuelo-2-2/
LOCATION:Spain
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260405T194933
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160120Z
UID:95955-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260405T194933
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160120Z
UID:95956-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine-2-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260405T194933
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160456Z
UID:25914-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine/
LOCATION:Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260405T194933
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160120Z
UID:95957-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine-3/
LOCATION:Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T080000
DTEND;TZID=Europe/Madrid:20161124T170000
DTSTAMP:20260405T194933
CREATED:20161121T094729Z
LAST-MODIFIED:20170801T110512Z
UID:25963-1479801600-1480006800@ibecbarcelona.eu
SUMMARY:NanoBio&Med2016
DESCRIPTION:NanoBio&Med2016 presents the most recent international developments in the field of Nanobiotechnology and Nanomedicine and will provide a platform for multidisciplinary communication\, new cooperations and projects to participants from both science and industry. \nEmerging and future trends of the converging fields of Nanotechnology\, Biotechnology and Medicine will be discussed among industry\, academia\, governmental and non-governmental institutions. NanoBio&Med2016 will be the perfect place to get a complete overview into the state of the art in those fields and also to learn about the research carried out and the latest results. The discussion in recent advances\, difficulties and breakthroughs will be at his higher level. \nAn industrial forum will be organized to promote constructive dialogue between business and public leaders and put specific emphasis on the technologies and applications in the nanoBioMed sector. \nFor more details and to register\, visit http://www.nanobiomedconf.com/NBM16/index.php
URL:https://ibecbarcelona.eu/event/nanobiomed2016/
LOCATION:UB Faculty of Medicine\, c/ Casanova 143\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T080000
DTEND;TZID=Europe/Madrid:20161124T170000
DTSTAMP:20260405T194933
CREATED:20161121T094729Z
LAST-MODIFIED:20161121T094729Z
UID:95958-1479801600-1480006800@ibecbarcelona.eu
SUMMARY:NanoBio&Med2016
DESCRIPTION:NanoBio&Med2016 presents the most recent international developments in the field of Nanobiotechnology and Nanomedicine and will provide a platform for multidisciplinary communication\, new cooperations and projects to participants from both science and industry. \nEmerging and future trends of the converging fields of Nanotechnology\, Biotechnology and Medicine will be discussed among industry\, academia\, governmental and non-governmental institutions. NanoBio&Med2016 will be the perfect place to get a complete overview into the state of the art in those fields and also to learn about the research carried out and the latest results. The discussion in recent advances\, difficulties and breakthroughs will be at his higher level. \nAn industrial forum will be organized to promote constructive dialogue between business and public leaders and put specific emphasis on the technologies and applications in the nanoBioMed sector. \nFor more details and to register\, visit http://www.nanobiomedconf.com/NBM16/index.php
URL:https://ibecbarcelona.eu/event/nanobiomed2016-2/
LOCATION:UB Faculty of Medicine\, c/ Casanova 143\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161118T120000
DTEND;TZID=Europe/Madrid:20161118T130000
DTSTAMP:20260405T194933
CREATED:20161111T084848Z
LAST-MODIFIED:20161111T084848Z
UID:95939-1479470400-1479474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Enabling technologies for biofabrication of functional materials and biomimetic environments
DESCRIPTION:Enabling technologies for biofabrication of functional materials and biomimetic environments\nDr. Alvaro Mata\, Director of the Institute of Bioengineering at Queen Mary University of London\nThe talk will present novel self-assembling and printing technologies enabling the fabrication of 2D and 3D bioactive and/or biomimetic materials for potential application in tissue engineering\, regenerative medicine\, and in vitro models. \nExamples of projects that will be presented include a) a bioactive membrane capable of growing hierarchically-ordered hydroxyapatite structures that resemble those found in human dental enamel; b) a dynamic self-assembling peptide-protein system capable of controllably accessing non-equilibrium to grow tubes and capillaries with potential application in tissue engineering; and c) a simple 3D molecular printing method to create distinct chemical environments ranging from tens of microns to centimeters in size and depth within different types of hydrogels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-enabling-technologies-for-biofabrication-of-functional-materials-and-biomimetic-environments-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161118T120000
DTEND;TZID=Europe/Madrid:20161118T130000
DTSTAMP:20260405T194933
CREATED:20161111T084848Z
LAST-MODIFIED:20161111T084848Z
UID:95940-1479470400-1479474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Enabling technologies for biofabrication of functional materials and biomimetic environments
DESCRIPTION:Enabling technologies for biofabrication of functional materials and biomimetic environments\nDr. Alvaro Mata\, Director of the Institute of Bioengineering at Queen Mary University of London\nThe talk will present novel self-assembling and printing technologies enabling the fabrication of 2D and 3D bioactive and/or biomimetic materials for potential application in tissue engineering\, regenerative medicine\, and in vitro models. \nExamples of projects that will be presented include a) a bioactive membrane capable of growing hierarchically-ordered hydroxyapatite structures that resemble those found in human dental enamel; b) a dynamic self-assembling peptide-protein system capable of controllably accessing non-equilibrium to grow tubes and capillaries with potential application in tissue engineering; and c) a simple 3D molecular printing method to create distinct chemical environments ranging from tens of microns to centimeters in size and depth within different types of hydrogels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-enabling-technologies-for-biofabrication-of-functional-materials-and-biomimetic-environments-2-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161118T120000
DTEND;TZID=Europe/Madrid:20161118T130000
DTSTAMP:20260405T194933
CREATED:20161111T084848Z
LAST-MODIFIED:20161111T084848Z
UID:95941-1479470400-1479474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Enabling technologies for biofabrication of functional materials and biomimetic environments
DESCRIPTION:Enabling technologies for biofabrication of functional materials and biomimetic environments\nDr. Alvaro Mata\, Director of the Institute of Bioengineering at Queen Mary University of London\nThe talk will present novel self-assembling and printing technologies enabling the fabrication of 2D and 3D bioactive and/or biomimetic materials for potential application in tissue engineering\, regenerative medicine\, and in vitro models. \nExamples of projects that will be presented include a) a bioactive membrane capable of growing hierarchically-ordered hydroxyapatite structures that resemble those found in human dental enamel; b) a dynamic self-assembling peptide-protein system capable of controllably accessing non-equilibrium to grow tubes and capillaries with potential application in tissue engineering; and c) a simple 3D molecular printing method to create distinct chemical environments ranging from tens of microns to centimeters in size and depth within different types of hydrogels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-enabling-technologies-for-biofabrication-of-functional-materials-and-biomimetic-environments-3/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161118T120000
DTEND;TZID=Europe/Madrid:20161118T130000
DTSTAMP:20260405T194933
CREATED:20161111T084848Z
LAST-MODIFIED:20161114T164758Z
UID:25831-1479470400-1479474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Enabling technologies for biofabrication of functional materials and biomimetic environments
DESCRIPTION:Enabling technologies for biofabrication of functional materials and biomimetic environments\nDr. Alvaro Mata\, Director of the Institute of Bioengineering at Queen Mary University of London\nThe talk will present novel self-assembling and printing technologies enabling the fabrication of 2D and 3D bioactive and/or biomimetic materials for potential application in tissue engineering\, regenerative medicine\, and in vitro models. \nExamples of projects that will be presented include a) a bioactive membrane capable of growing hierarchically-ordered hydroxyapatite structures that resemble those found in human dental enamel; b) a dynamic self-assembling peptide-protein system capable of controllably accessing non-equilibrium to grow tubes and capillaries with potential application in tissue engineering; and c) a simple 3D molecular printing method to create distinct chemical environments ranging from tens of microns to centimeters in size and depth within different types of hydrogels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-enabling-technologies-for-biofabrication-of-functional-materials-and-biomimetic-environments/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161116T123000
DTEND;TZID=Europe/Madrid:20161116T133000
DTSTAMP:20260405T194933
CREATED:20161111T084218Z
LAST-MODIFIED:20161115T115233Z
UID:25828-1479299400-1479303000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Silvia Muro\, Nanobiotechnology for drug delivery
DESCRIPTION:Nanobio-technology for drug delivery: fundamental aspects and translational applications\nDr. Silvia Muro\, University of Maryland\, College Park\, MD\, USA\nThe design of targeting and carrier strategies to enable delivery of therapeutic or diagnostic agents to areas of the body requiring intervention is an active research field. Therapeutic and diagnostic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the circulation into the subjacent tissue. In addition\, once within the tissue or body compartment of interest\, most targets of intervention relate to sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, further requiring strategies to achieve this goal. \nUsing polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and into cells of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and uptake by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nanobio-technology-for-drug-delivery-fundamental-aspects-and-translational-applications/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161116T123000
DTEND;TZID=Europe/Madrid:20161116T133000
DTSTAMP:20260405T194933
CREATED:20161111T084218Z
LAST-MODIFIED:20161111T084218Z
UID:95938-1479299400-1479303000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Silvia Muro\, Nanobiotechnology for drug delivery
DESCRIPTION:Nanobio-technology for drug delivery: fundamental aspects and translational applications\nDr. Silvia Muro\, University of Maryland\, College Park\, MD\, USA\nThe design of targeting and carrier strategies to enable delivery of therapeutic or diagnostic agents to areas of the body requiring intervention is an active research field. Therapeutic and diagnostic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the circulation into the subjacent tissue. In addition\, once within the tissue or body compartment of interest\, most targets of intervention relate to sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, further requiring strategies to achieve this goal. \nUsing polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and into cells of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and uptake by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nanobio-technology-for-drug-delivery-fundamental-aspects-and-translational-applications-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161116T123000
DTEND;TZID=Europe/Madrid:20161116T133000
DTSTAMP:20260405T194933
CREATED:20161111T084218Z
LAST-MODIFIED:20161111T084218Z
UID:95942-1479299400-1479303000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nanobio-technology for drug delivery: fundamental aspects and translational applications
DESCRIPTION:Nanobio-technology for drug delivery: fundamental aspects and translational applications\nDr. Silvia Muro\, University of Maryland\, College Park\, MD\, USA\nThe design of targeting and carrier strategies to enable delivery of therapeutic or diagnostic agents to areas of the body requiring intervention is an active research field. Therapeutic and diagnostic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the circulation into the subjacent tissue. In addition\, once within the tissue or body compartment of interest\, most targets of intervention relate to sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, further requiring strategies to achieve this goal. \nUsing polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and into cells of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and uptake by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nanobio-technology-for-drug-delivery-fundamental-aspects-and-translational-applications-2-2/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161116T123000
DTEND;TZID=Europe/Madrid:20161116T133000
DTSTAMP:20260405T194933
CREATED:20161111T084218Z
LAST-MODIFIED:20161111T084218Z
UID:95943-1479299400-1479303000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nanobio-technology for drug delivery: fundamental aspects and translational applications
DESCRIPTION:Nanobio-technology for drug delivery: fundamental aspects and translational applications\nDr. Silvia Muro\, University of Maryland\, College Park\, MD\, USA\nThe design of targeting and carrier strategies to enable delivery of therapeutic or diagnostic agents to areas of the body requiring intervention is an active research field. Therapeutic and diagnostic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the circulation into the subjacent tissue. In addition\, once within the tissue or body compartment of interest\, most targets of intervention relate to sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, further requiring strategies to achieve this goal. \nUsing polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and into cells of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and uptake by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nanobio-technology-for-drug-delivery-fundamental-aspects-and-translational-applications-3/
LOCATION:Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161115T180000
DTEND;TZID=Europe/Madrid:20161115T203000
DTSTAMP:20260405T194933
CREATED:20161014T011207Z
LAST-MODIFIED:20170801T110546Z
UID:24961-1479232800-1479241800@ibecbarcelona.eu
SUMMARY:Setmana de la Ciència 2016: nanoROBOTS
DESCRIPTION:  \nImagina un submarí tan petit que pogués navegar dins del nostre torrent sanguini per portar fàrmacs allà on fos necessari. Sembla increïble oi?\nSamuel Sánchez\, expert en nanorobots\, ens explicarà els reptes als quals s’enfronten per fer-ho possible. \n\nEl proper dimarts 15 de novembre\, l’IBEC organitza una jornada de portes obertes on els visitants podran descobrir l’entorn on treballen els nostres investigadors i apropar-se al món dels nanoROBOTS. \n18:00 Visita als laboratoris (grup reduït)\n19:00 Xerrada divulgativa \nActivitat gratuïta\n Per majors de 16 anys\n Places limitades\nPer inscripcions enviar un mail a: ibecevents@ibecbarcelona.eu \nhttp://www.fundaciorecerca.cat/setmanaciencia
URL:https://ibecbarcelona.eu/event/open-day-as-part-of-setmana-de-la-ciencia/
LOCATION:Sala Dolors Aleu\, Cluster II\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Outreach / Fair / Festival
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
END:VCALENDAR