BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.3.5//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Institute for Bioengineering of Catalonia X-ORIGINAL-URL:https://ibecbarcelona.eu X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Madrid BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20221102T153000 DTEND;TZID=Europe/Madrid:20221102T173000 DTSTAMP:20240328T161355 CREATED:20221025T111442Z LAST-MODIFIED:20221031T092456Z UID:100038-1667403000-1667410200@ibecbarcelona.eu SUMMARY:IBEC Seminar: Felipe Galvez-Cancino (canceled) DESCRIPTION: URL:https://ibecbarcelona.eu/event/ibec-seminar-felipe-galvez-cancino/ LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain CATEGORIES:IBEC Seminar ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20221109T160000 DTEND;TZID=Europe/Madrid:20221109T180000 DTSTAMP:20240328T161355 CREATED:20221028T104835Z LAST-MODIFIED:20221028T104906Z UID:100158-1668009600-1668016800@ibecbarcelona.eu SUMMARY:IBEC Seminar: Takashi Hiiragi DESCRIPTION:Multicellular coordination in context\nTakashi Hiiragi\, Hubrecht Institute\, The Netherlands \nA defining feature of living systems is the capacity to break symmetry and generate well-defined forms and patterns through self-organisation. Our group aims to understand the design principle of multicellular living systems using early mouse embryos as a model system. We developed an experimental framework that integrates biology\, physics and mathematics\, to understand how molecular\, cellular and physical signals are dynamically coupled across the scales for self-organisation. I will discuss our ongoing work investigating the coordination of developmental programmes in space and time. \n\nTakashi Hiiragi is group leader at the Hubrecht Institute.  The Hiiragi group aims to understand what defines multi-cellular living systems. In particular\, the group studies the design principle of tissue self-organization\, using early mammalian embryos as a model system. To this end\, they developed an experimental framework that integrates biology\, physics and mathematics. Their recent studies led to a model in which feedback between cell fate\, polarity\, and cell and tissue mechanics underlies multi-cellular self-organization. The group adopts a wide variety of experimental strategies including embryology\, genetics\, advanced microscopy\, biophysics\, engineering and theoretical modelling\, in order to address fundamental questions in cell and developmental biology. URL:https://ibecbarcelona.eu/event/ibec-seminar-takashi-hiiragi/ LOCATION:Sala Baobab\, Tower I - 11th floor CATEGORIES:IBEC Seminar ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20221111T100000 DTEND;TZID=Europe/Madrid:20221111T120000 DTSTAMP:20240328T161355 CREATED:20221104T105722Z LAST-MODIFIED:20221104T105722Z UID:100305-1668160800-1668168000@ibecbarcelona.eu SUMMARY:IBEC Seminar: Astrid Viciano DESCRIPTION:Is the price of pharmaceutical drugs justified?\nAstrid Viciano\, IBEC \n10 euros\, 1000 euros\, or rather 1 million? Many new medicines that have recently reached the market are prohibitively expensive. But are these prices justified? Science reporter Astrid Viciano has investigated the high prices of innovative therapies. For these investigations\, she received a number of European journalism stipends. \nViciano will explain how the pharmaceutical industry calculates prices for new drugs\, and who currently determines the costs for new medications in different healthcare systems. Looking into different\, concrete examples such as the drug Zolgensma for the treatment of spinal muscular atrophy\, she will point out how drugs are currently developed and approved\, and how medications for orphan diseases are developed. Moreover\, looking into historic examples such as insulin\, she will look into why access to potentially life-saving drugs is still not guaranteed in all regions of the world\, an urgent problem the Covid-19 pandemic has highlighted in the past two years. \n\nDr. Astrid Viciano has been working as a science journalist for German national media such as Süddeutsche Zeitung\, Die Zeit\, Spiegel\, and GEO for more than 20 years. \nShe has worked in a variety of European cross-border teams\, focusing on in-depth investigative science reporting.  From 2012 to 2016\, she worked as a freelance reporter from Paris\, and from 2009 and 2011 in Los Angeles. She has published articles in German\, English\, Dutch and Spanish. Viciano has won several national and international journalism awards\, grants\, and fellowships. \nAstrid Viciano is a medical doctor with a doctorate in immunology and virology and also has an M.A. in Specialized Journalism (USC Annenberg ’11). Currently she is „journalist-in-residence“ at IBEC. She holds the Spanish and German nationalities. URL:https://ibecbarcelona.eu/event/ibec-seminar-astrid-viciano/ LOCATION:Sala Baobab\, Tower I\, Floor 11\, Baldiri i Reixac\, Barcelona CATEGORIES:IBEC Seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20221118T090000 DTEND;TZID=Europe/Madrid:20221118T163000 DTSTAMP:20240328T161355 CREATED:20221028T104336Z LAST-MODIFIED:20221028T104336Z UID:99987-1668762000-1668789000@ibecbarcelona.eu SUMMARY:Phys2BioMed Symposium DESCRIPTION:Phys2BioMed Symposium\nPresent and future of mechanics of cells and tissues in health and disease\nThe mechanical properties of biological samples may provide insights into many physiological and pathological processes. Examples are the mechanical properties of cancer cells or changes of mechanical properties during cell invasion. Defining standardized procedures for nanomechanical measurements and providing\, in the longer-term\, a data bank of mechanical fingerprints of diseases\, can lead to the development of effective early-diagnostic tools. \nPhys2BioMed is an ITN (Innovative Training Network) that has the purpose of providing scientific and technological outcomes on biomechanics and mechanical determinants of diseases. The key advantage is merging diverse competences at the European level\, from different fields like nanoscience and nanotechnology\, physics\, biology\, and medicine. Thanks to the participation of hospitals and companies\, ESRs (Early Stage Researchers) are exposed also to the non-academic sector. \nThe scientific community is invited to participate in person or online in this symposium. \nCheck for the programme and register here. URL:https://ibecbarcelona.eu/event/phys2biomed-symposium/ LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain CATEGORIES:External symposium / conference / congress END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20221121T183000 DTEND;TZID=Europe/Madrid:20221121T193000 DTSTAMP:20240328T161355 CREATED:20221117T152328Z LAST-MODIFIED:20221117T152546Z UID:101231-1669055400-1669059000@ibecbarcelona.eu SUMMARY:L’estat de la Ciència a Catalunya DESCRIPTION:La investigació científica i tecnològica ha estat una de les claus del progrés de la societat de forma exponencial en els darrers anys. Aquesta investigació\, però\, només es pot portar a terme quan es té un ecosistema ric que permet als investigadors començar la seva tasca i desenvolupar-se. Quina és la situació actual a Catalunya? Quin és el marc català i quina és la perspectiva de futur? En parlem en aquesta sessió.\nA càrrec de Josep Samitier Martí\, director de l’Institut de Bioenginyeria de Catalunya (IBEC) i president de l’Associació Catalana d’Entitats de Recerca (ACER)\nPresenta l’acte: Aleix Ràmia\, ponent de la Secció. \n  URL:https://ibecbarcelona.eu/event/101231/ LOCATION:Ateneu Barcelonès\, Canuda 6\, Barcelona\, 08002 CATEGORIES:External seminar END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20221125T100000 DTEND;TZID=Europe/Madrid:20221125T120000 DTSTAMP:20240328T161355 CREATED:20221116T090407Z LAST-MODIFIED:20221116T090407Z UID:101122-1669370400-1669377600@ibecbarcelona.eu SUMMARY:PhD Discussions: Maria Gallo and Nimesh Chahare DESCRIPTION:Generation Of Reporter Human Pluripotent Stem Cell Lines To Study Cardiac Development And Disease\nMaria Gallo\, Pluripotency for organ regeneration Group \nThe development and the use of human pluripotent stem cells (hPSCs) represent an effective tool to recapitulate characteristics related to tissue differentiation\, morphogenesis and conversely\, human diseases. Through their inherent capacity to differentiate towards the three germ layers and their easy manipulation\, it has been possible to generate three dimensional (3D) self-organized organ-like structures\, the so-called organoids. In this context\, the advent of CRISPR-Cas9 technology has now allow to incorporate permanent or transient changes in the genome of living organisms and cells. Our laboratory has developed a cellular platform\, named iCRISPR2 (iC2)\, that allows to perform highly efficient genome editing in hPSCs through the insertion of an inducible Cas9 under the endogenous TET/ON promoter. This platform allowed us the generation of reporter\, knock-out and knock-in hPSCs lines. By exploiting the generation of cardiac reporter cell lines it has been possible to define new approaches for the generation of self-assembled cardiac-like organoids. Cardioids have been characterized at conventional molecular biology techniques\, confocal microscopy and functional analysis. Moreover\, taking advantages of specific cell culture conditions emulating early stages of diabetic cardiomyopathy it has been possible to establish a platform for the interrogation of transcriptional and functional changes during diabetic disease. \n\nMechanics of epithelial layers subjected to controlled pressure\nNimesh Chahare\, Integrative cell and tissue dynamics Group \nEpithelial sheets form specialized 3D structures suited to their physiological roles\, such as branched alveoli in the lungs\, tubes in the kidney\, and villi in the intestine. To generate and maintain these structures\, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses\, viscoelasticity\, and luminal pressure remains poorly understood. To address this question\, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup\, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure\, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach\, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However\, under sudden pressure reductions\, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am. URL:https://ibecbarcelona.eu/event/phd-discussions-maria-gallo-and-nimesh-chahare/ LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain CATEGORIES:PhD Discussions Complementary Skills Session END:VEVENT END:VCALENDAR