BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260503T142704
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T155752Z
UID:96586-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Control òptic de receptors endògens i excitabilitat cel·lular amb llum\nAida Garrido\, Nanoprobes and nanoswitches group \nL’estudi electrofisiològic i d’imatge de l’activitat neuronal en temps real requereix una gran resolució espacial i temporal. Ambdós trets es poden aconseguir amb la precisió\, velocitat i control remot que permet la llum. En aquesta tesi es descriu la caracterització de nous fotocommutadors dirigits a fotosensibilitzar receptors endògens de glutamat i estratègies per la millora de les seves característiques òptiques.\nEls primers fotoconmutadors descrits capaços de controlar amb llum l’activitat de canals endògens de glutamat son eficaços en altres aproximacions experimentals com ara en la inducció amb llum de potencials d’acció en neurones en cultiu\, en cultius organotípics d’hipocamp de rata o in vivo en larves de Xenopus electroporades\, a nivell d’un grup neuronal\, d’una única neurona o d’una única espina sinàptica. Modificant la part reactiva del fotocommutador\, som podem controlar espacialment la conjugació mitjançant patrons d’il·luminació.\nCanviant l’estructura química s’aconsegueix un fotocommutador actiu en el rang visible de llum i alhora extremadament ràpid. Fet que el fa ideal pel control de sinapsis ultra ràpides com ara les encarregades de codificar el so en la còclea. El disseny racional d’altres modificacions químiques en fotocommutadors de receptors de glutamat (LiGluRs) obre les portes al disseny de molècules sensibles a l’activació per 2 fotons. L’estimulació de 2 fotons amb làsers polsats de llum infraroja comporta importants avantatges com ara l’augment de la capacitat de penetració en teixit i una disminució de possibles danys degut a una sobreexposició a la llum. Característiques molt útils per estudis in vivo. Modificacions químiques dels fotocommutadors comporten altres modificacions en les seves característiques fotodinàmiques. Per aquest motiu\, hem desenvolupat una estratègia de conjugació de fluoròfors col·lectors de llum que mitjançant RET transfereixen la seva energia al cromòfor (fotocommutador)\, modificant-ne les característiques espectrals.\nEs demostra que cromòfors no conjugables permeten controlar l’activitat neuronal. Amb diversos avantatges respecte l’azobenzè clàssic: els azobenzens cíclics reverteix l’estabilitat i en conseqüència l’activitat de la molècula; i els estilbens permeten l’activació irreversible però no foto-destructiva de la molècula original\, evitant així la creació de foto-productes.\nEn conclusió\, en aquesta tesi es presenten noves molècules i estratègies de disseny per al control de la neurotransmissió sense necessitat de modificacions genètiques.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido-2/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260503T142704
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T155752Z
UID:96587-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido-2/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260503T142704
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T155752Z
UID:96590-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido-3/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260503T142704
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T160144Z
UID:70283-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200116T120000
DTEND;TZID=Europe/Madrid:20200116T140000
DTSTAMP:20260503T142704
CREATED:20200110T113019Z
LAST-MODIFIED:20200110T113032Z
UID:70211-1579176000-1579183200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anotine Huet
DESCRIPTION:Cochlear optical stimulation of the auditory pathway\nAntoine Huet \, Institut für Auditorische Neurowissenschaften\, Universitätsmedizin Göttingen \nOptical stimulation of spiral ganglion neurons (SGNs) in the ear for coding sound information provides an interesting alternative to electrical stimulation that is used in current cochlear implants for hearing restoration. As light can be conveniently confined in space\, optical stimulation promises not only to increase the number of independent stimulation channels\, but also potentially to restore temporal response of SGNs which are phase-locked to the periodicity of the sound. Sensitizing SGNs to light can be achieved either by optogenetic manipulation for expressing a light-sensitive protein\, or by photopharmacological manipulation of receptors native to the cochlea. \nPioneering studies have established proof of principle of optical cochlear stimulation to restore hearing in rodent models of deafness (Hernandez et al\, 2014; Wrobel\, Dieter et al\, 2018). More recent work from the last 2 years have demonstrated i) improvement of frequency selectivity in response to light-over electrical stimuli (Dieter et al\, 2019)\, and ii) activation of the auditory pathway by faster opsins (i.e. shorter closing kinetics) which are more suitable for fast spiking SGNs (Mager\, Lopez de la Morena et al\, 2018\, Keppeler et al\, 2018). Finally\, ongoing work\, in collaboration with the team of Pau Gorostiza\, is showing than a photopharmacological approach targeting AMPA receptors could be used to optically activate the auditory pathway with performance similar to current optogenetic tools. \nDr. Antoine Huet is a postdoctoral fellow in the Institute for Auditory Neuroscience (University Medical Center Göttingen) under the supervision of Prof. Dr. Tobias Moser. Dr Huet received his BS degree in Audiology from the Institut libre Marie-Haps (Brussel\, Belgium) and MS degree in Audiology and auditory neuroscience from the University of Montpellier 1 (Montpellier\, France). He obtained his PhD degree in Chemical and biological science for Health from the University of Montpellier 1 (Montpellier\, France). He worked as a Postdoctoral fellow under the supervision of Pr. J-L. Puel and Jerome Bourien\, PhD in the Institut des neurosciences de Montpellier (INSERM U1051\, France) till May 2018. After\, he joined the laboratory of Pr. Dr. Tobias Moser in the Institute for Auditory Neuroscience from the University Medical Center Göttingen (Germany). His current research interest include the development of viral transfer of suitable ChR variants into spiral ganglion neurons and of multichannel optical stimulation using cochlear implants with arrays of microscale light emitting diodes and waveguides\, characterizing neuronal responses along the auditory pathway using physiological and behavioral methods. Thus\, to finally compare optogenetic to acoustic and electric stimulation. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-anotine-huet/
LOCATION:Torre I Sala 3 Planta -1\, Carrer Baldiri Reixac 4-8\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200116T120000
DTEND;TZID=Europe/Madrid:20200116T140000
DTSTAMP:20260503T142704
CREATED:20200110T113019Z
LAST-MODIFIED:20200110T113019Z
UID:96580-1579176000-1579183200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anotine Huet
DESCRIPTION:Cochlear optical stimulation of the auditory pathway\nAntoine Huet \, Institut für Auditorische Neurowissenschaften\, Universitätsmedizin Göttingen \nOptical stimulation of spiral ganglion neurons (SGNs) in the ear for coding sound information provides an interesting alternative to electrical stimulation that is used in current cochlear implants for hearing restoration. As light can be conveniently confined in space\, optical stimulation promises not only to increase the number of independent stimulation channels\, but also potentially to restore temporal response of SGNs which are phase-locked to the periodicity of the sound. Sensitizing SGNs to light can be achieved either by optogenetic manipulation for expressing a light-sensitive protein\, or by photopharmacological manipulation of receptors native to the cochlea. \nPioneering studies have established proof of principle of optical cochlear stimulation to restore hearing in rodent models of deafness (Hernandez et al\, 2014; Wrobel\, Dieter et al\, 2018). More recent work from the last 2 years have demonstrated i) improvement of frequency selectivity in response to light-over electrical stimuli (Dieter et al\, 2019)\, and ii) activation of the auditory pathway by faster opsins (i.e. shorter closing kinetics) which are more suitable for fast spiking SGNs (Mager\, Lopez de la Morena et al\, 2018\, Keppeler et al\, 2018). Finally\, ongoing work\, in collaboration with the team of Pau Gorostiza\, is showing than a photopharmacological approach targeting AMPA receptors could be used to optically activate the auditory pathway with performance similar to current optogenetic tools. \nDr. Antoine Huet is a postdoctoral fellow in the Institute for Auditory Neuroscience (University Medical Center Göttingen) under the supervision of Prof. Dr. Tobias Moser. Dr Huet received his BS degree in Audiology from the Institut libre Marie-Haps (Brussel\, Belgium) and MS degree in Audiology and auditory neuroscience from the University of Montpellier 1 (Montpellier\, France). He obtained his PhD degree in Chemical and biological science for Health from the University of Montpellier 1 (Montpellier\, France). He worked as a Postdoctoral fellow under the supervision of Pr. J-L. Puel and Jerome Bourien\, PhD in the Institut des neurosciences de Montpellier (INSERM U1051\, France) till May 2018. After\, he joined the laboratory of Pr. Dr. Tobias Moser in the Institute for Auditory Neuroscience from the University Medical Center Göttingen (Germany). His current research interest include the development of viral transfer of suitable ChR variants into spiral ganglion neurons and of multichannel optical stimulation using cochlear implants with arrays of microscale light emitting diodes and waveguides\, characterizing neuronal responses along the auditory pathway using physiological and behavioral methods. Thus\, to finally compare optogenetic to acoustic and electric stimulation. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-anotine-huet-2/
LOCATION:Torre I Sala 3 Planta -1\, Carrer Baldiri Reixac 4-8\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200116T120000
DTEND;TZID=Europe/Madrid:20200116T140000
DTSTAMP:20260503T142704
CREATED:20200110T113019Z
LAST-MODIFIED:20200110T113019Z
UID:96581-1579176000-1579183200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anotine Huet
DESCRIPTION:Cochlear optical stimulation of the auditory pathway\nAntoine Huet \, Institut für Auditorische Neurowissenschaften\, Universitätsmedizin Göttingen \nOptical stimulation of spiral ganglion neurons (SGNs) in the ear for coding sound information provides an interesting alternative to electrical stimulation that is used in current cochlear implants for hearing restoration. As light can be conveniently confined in space\, optical stimulation promises not only to increase the number of independent stimulation channels\, but also potentially to restore temporal response of SGNs which are phase-locked to the periodicity of the sound. Sensitizing SGNs to light can be achieved either by optogenetic manipulation for expressing a light-sensitive protein\, or by photopharmacological manipulation of receptors native to the cochlea. \nPioneering studies have established proof of principle of optical cochlear stimulation to restore hearing in rodent models of deafness (Hernandez et al\, 2014; Wrobel\, Dieter et al\, 2018). More recent work from the last 2 years have demonstrated i) improvement of frequency selectivity in response to light-over electrical stimuli (Dieter et al\, 2019)\, and ii) activation of the auditory pathway by faster opsins (i.e. shorter closing kinetics) which are more suitable for fast spiking SGNs (Mager\, Lopez de la Morena et al\, 2018\, Keppeler et al\, 2018). Finally\, ongoing work\, in collaboration with the team of Pau Gorostiza\, is showing than a photopharmacological approach targeting AMPA receptors could be used to optically activate the auditory pathway with performance similar to current optogenetic tools. \nDr. Antoine Huet is a postdoctoral fellow in the Institute for Auditory Neuroscience (University Medical Center Göttingen) under the supervision of Prof. Dr. Tobias Moser. Dr Huet received his BS degree in Audiology from the Institut libre Marie-Haps (Brussel\, Belgium) and MS degree in Audiology and auditory neuroscience from the University of Montpellier 1 (Montpellier\, France). He obtained his PhD degree in Chemical and biological science for Health from the University of Montpellier 1 (Montpellier\, France). He worked as a Postdoctoral fellow under the supervision of Pr. J-L. Puel and Jerome Bourien\, PhD in the Institut des neurosciences de Montpellier (INSERM U1051\, France) till May 2018. After\, he joined the laboratory of Pr. Dr. Tobias Moser in the Institute for Auditory Neuroscience from the University Medical Center Göttingen (Germany). His current research interest include the development of viral transfer of suitable ChR variants into spiral ganglion neurons and of multichannel optical stimulation using cochlear implants with arrays of microscale light emitting diodes and waveguides\, characterizing neuronal responses along the auditory pathway using physiological and behavioral methods. Thus\, to finally compare optogenetic to acoustic and electric stimulation. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-anotine-huet-3/
LOCATION:Torre I Sala 3 Planta -1\, Carrer Baldiri Reixac 4-8\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200116T120000
DTEND;TZID=Europe/Madrid:20200116T140000
DTSTAMP:20260503T142704
CREATED:20200110T113019Z
LAST-MODIFIED:20200110T113019Z
UID:96583-1579176000-1579183200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anotine Huet
DESCRIPTION:Cochlear optical stimulation of the auditory pathway\nAntoine Huet \, Institut für Auditorische Neurowissenschaften\, Universitätsmedizin Göttingen \nOptical stimulation of spiral ganglion neurons (SGNs) in the ear for coding sound information provides an interesting alternative to electrical stimulation that is used in current cochlear implants for hearing restoration. As light can be conveniently confined in space\, optical stimulation promises not only to increase the number of independent stimulation channels\, but also potentially to restore temporal response of SGNs which are phase-locked to the periodicity of the sound. Sensitizing SGNs to light can be achieved either by optogenetic manipulation for expressing a light-sensitive protein\, or by photopharmacological manipulation of receptors native to the cochlea. \nPioneering studies have established proof of principle of optical cochlear stimulation to restore hearing in rodent models of deafness (Hernandez et al\, 2014; Wrobel\, Dieter et al\, 2018). More recent work from the last 2 years have demonstrated i) improvement of frequency selectivity in response to light-over electrical stimuli (Dieter et al\, 2019)\, and ii) activation of the auditory pathway by faster opsins (i.e. shorter closing kinetics) which are more suitable for fast spiking SGNs (Mager\, Lopez de la Morena et al\, 2018\, Keppeler et al\, 2018). Finally\, ongoing work\, in collaboration with the team of Pau Gorostiza\, is showing than a photopharmacological approach targeting AMPA receptors could be used to optically activate the auditory pathway with performance similar to current optogenetic tools. \nDr. Antoine Huet is a postdoctoral fellow in the Institute for Auditory Neuroscience (University Medical Center Göttingen) under the supervision of Prof. Dr. Tobias Moser. Dr Huet received his BS degree in Audiology from the Institut libre Marie-Haps (Brussel\, Belgium) and MS degree in Audiology and auditory neuroscience from the University of Montpellier 1 (Montpellier\, France). He obtained his PhD degree in Chemical and biological science for Health from the University of Montpellier 1 (Montpellier\, France). He worked as a Postdoctoral fellow under the supervision of Pr. J-L. Puel and Jerome Bourien\, PhD in the Institut des neurosciences de Montpellier (INSERM U1051\, France) till May 2018. After\, he joined the laboratory of Pr. Dr. Tobias Moser in the Institute for Auditory Neuroscience from the University Medical Center Göttingen (Germany). His current research interest include the development of viral transfer of suitable ChR variants into spiral ganglion neurons and of multichannel optical stimulation using cochlear implants with arrays of microscale light emitting diodes and waveguides\, characterizing neuronal responses along the auditory pathway using physiological and behavioral methods. Thus\, to finally compare optogenetic to acoustic and electric stimulation. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-anotine-huet-3/
LOCATION:Torre I Sala 3 Planta -1\, Carrer Baldiri Reixac 4-8\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200131T100000
DTEND;TZID=Europe/Madrid:20200131T120000
DTSTAMP:20260503T142704
CREATED:20200127T075750Z
LAST-MODIFIED:20200127T075750Z
UID:96596-1580464800-1580472000@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Complementary Skills Session: Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance
DESCRIPTION:Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance\nEduard Aibar – Professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC) \nThis seminar will present some basic points of the recent view of science produced by fields like the philosophy of science\, the sociology of science and the history of science. We will highlight the strong contrast between this view and the traditional view of science – still dominant in many areas of society – particularly around matters like the scientific method\, the evolution of science and the role of controversies. We will also discuss a few important phenomena of contemporary science: the productivist view of research evaluation\, the privatization of scientific knowledge and\, finally\, agnotology – the systematic production of ignorance. \nEduard Aibar is professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC). He has been the director of the Internet Interdisciplinary Institute and former vice-president for research at UOC. He is currently leading a research group on Open Science and Innovation. His research has focused on the interaction between scientific and technological development and organizational and social change in areas such as eGovernment\, town planning and the Internet. He has recently led two research projects on Wikipedia and the public communication of science. \nFor more info see: https://www.uoc.edu/webs/eaibar
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-complementary-skills-session-some-philosophical-sociological-issues-about-present-science-from-the-privatization-of-science-to-the-production-of-ignorance-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200131T100000
DTEND;TZID=Europe/Madrid:20200131T120000
DTSTAMP:20260503T142704
CREATED:20200127T075750Z
LAST-MODIFIED:20200127T075750Z
UID:96598-1580464800-1580472000@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Complementary Skills Session: Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance
DESCRIPTION:Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance\nEduard Aibar – Professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC) \nThis seminar will present some basic points of the recent view of science produced by fields like the philosophy of science\, the sociology of science and the history of science. We will highlight the strong contrast between this view and the traditional view of science – still dominant in many areas of society – particularly around matters like the scientific method\, the evolution of science and the role of controversies. We will also discuss a few important phenomena of contemporary science: the productivist view of research evaluation\, the privatization of scientific knowledge and\, finally\, agnotology – the systematic production of ignorance. \nEduard Aibar is professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC). He has been the director of the Internet Interdisciplinary Institute and former vice-president for research at UOC. He is currently leading a research group on Open Science and Innovation. His research has focused on the interaction between scientific and technological development and organizational and social change in areas such as eGovernment\, town planning and the Internet. He has recently led two research projects on Wikipedia and the public communication of science. \nFor more info see: https://www.uoc.edu/webs/eaibar
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-complementary-skills-session-some-philosophical-sociological-issues-about-present-science-from-the-privatization-of-science-to-the-production-of-ignorance-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200131T100000
DTEND;TZID=Europe/Madrid:20200131T120000
DTSTAMP:20260503T142704
CREATED:20200127T075750Z
LAST-MODIFIED:20200127T075750Z
UID:96599-1580464800-1580472000@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Complementary Skills Session: Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance
DESCRIPTION:Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance\nEduard Aibar – Professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC) \nThis seminar will present some basic points of the recent view of science produced by fields like the philosophy of science\, the sociology of science and the history of science. We will highlight the strong contrast between this view and the traditional view of science – still dominant in many areas of society – particularly around matters like the scientific method\, the evolution of science and the role of controversies. We will also discuss a few important phenomena of contemporary science: the productivist view of research evaluation\, the privatization of scientific knowledge and\, finally\, agnotology – the systematic production of ignorance. \nEduard Aibar is professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC). He has been the director of the Internet Interdisciplinary Institute and former vice-president for research at UOC. He is currently leading a research group on Open Science and Innovation. His research has focused on the interaction between scientific and technological development and organizational and social change in areas such as eGovernment\, town planning and the Internet. He has recently led two research projects on Wikipedia and the public communication of science. \nFor more info see: https://www.uoc.edu/webs/eaibar
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-complementary-skills-session-some-philosophical-sociological-issues-about-present-science-from-the-privatization-of-science-to-the-production-of-ignorance-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200131T100000
DTEND;TZID=Europe/Madrid:20200131T120000
DTSTAMP:20260503T142704
CREATED:20200127T075750Z
LAST-MODIFIED:20200127T075810Z
UID:70739-1580464800-1580472000@ibecbarcelona.eu
SUMMARY:IBEC PhD Discussions Complementary Skills Session: Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance
DESCRIPTION:Some philosophical & sociological issues about present science: from the privatization of science to the production of ignorance\nEduard Aibar – Professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC) \nThis seminar will present some basic points of the recent view of science produced by fields like the philosophy of science\, the sociology of science and the history of science. We will highlight the strong contrast between this view and the traditional view of science – still dominant in many areas of society – particularly around matters like the scientific method\, the evolution of science and the role of controversies. We will also discuss a few important phenomena of contemporary science: the productivist view of research evaluation\, the privatization of scientific knowledge and\, finally\, agnotology – the systematic production of ignorance. \nEduard Aibar is professor of Science and Technology Studies at the Arts & Humanities Department\, Universitat Oberta de Catalunya (UOC). He has been the director of the Internet Interdisciplinary Institute and former vice-president for research at UOC. He is currently leading a research group on Open Science and Innovation. His research has focused on the interaction between scientific and technological development and organizational and social change in areas such as eGovernment\, town planning and the Internet. He has recently led two research projects on Wikipedia and the public communication of science. \nFor more info see: https://www.uoc.edu/webs/eaibar
URL:https://ibecbarcelona.eu/event/ibec-phd-discussions-complementary-skills-session-some-philosophical-sociological-issues-about-present-science-from-the-privatization-of-science-to-the-production-of-ignorance/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
END:VCALENDAR