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DTSTART;TZID=Europe/Madrid:20200703T100000
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CREATED:20200605T081640Z
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SUMMARY:Online IBEC Seminar: Santiago Marco
DESCRIPTION:Signal and Data Processing Workflows for Untargeted Chemical Analysis: Sensor Array and Mass Spectrometry Analysis of Complex Gas Samples\nSantiago Marco \, IBEC \nIn diverse sectors such as health\, food\, environment\, complex natural gas samples are analysed. Those samples can contain hundreds or thousands of compounds. In many cases\, the question to be answered does not require full separation\, quantification\, and identification of all compounds. Instead detection of abnormal samples (normal/ faulty)\, assignation of classes to samples (e.g.healthy/disease)\, or evaluation of global quantitative indexes (e.g odour intensity) is required. \nThe analysis of gas phase samples can be carried out with high-end lab equipment based on Chromatography-Mass Spectrometry or lower cost systems based on chemical sensors. In all cases\, the resulting raw signals/data need substantial efforts to extract the hidden information. In health applications the problem of biomarker discovery becomes like finding a needle in a haystack. Intimate knowledge of the instrumental problems and the sampling conditions is key for the correct interpretation of the results. \nThese problems are often addressed by building mega-variate predictive models using tools from machine learning. However\, in small sample conditions the possibilities to obtain overoptimistic results abound due to the curse of dimensionality. Careful model validation and statement of model validity domains is needed. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Santiago Marco’s research here \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-santiago-marco/
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20200716T110000
DTEND;TZID=Europe/Madrid:20200716T130000
DTSTAMP:20260501T193318
CREATED:20200706T063623Z
LAST-MODIFIED:20200707T090653Z
UID:75980-1594897200-1594904400@ibecbarcelona.eu
SUMMARY:PhD Thesis defense: Helena Lozano
DESCRIPTION:Electrical and topographical study of bacterial appendages at the nanoscale\nHelena Lozano\, Nanoscale bioelectrical characterization group \nSome bacteria can exchange electrons with non-soluble electron acceptors\, such as minerals. This phenomenon is called Extracellular Electron Transfer (EET) and it can be done through several mechanisms\, especially through conductive bacterial nanowires. \nThe main objective of this thesis is the investigation of the polarization properties of electrochemically active bacteria and their appendages. Specifically\, I have studied two types of bacteria\, Shewanella oneidensis MR-1 and cable bacteria. I have used the Electrostatic Force Microscopy (EFM)\, which measures the electrostatic force using a nanometric probe\, combined with finite element simulations to obtain the polarization properties. The electrostatic force depends mainly on the geometry and dielectric constant of the probe-sample system. \nFirst\, I have developed a way to obtain the dimensions of objects avoiding physical contact with the sample by measuring the electrostatic force. I have tested this technique on silver nanowires and bacterial flagella\, optimizing the EFM technique to nanowire-like biological samples at the nanoscale. Afterward\, I have studied S. oneidensis Outer Membrane Extensions (OMEs)\, responsible for the EET. I have obtained a low value of the dielectric constant (εOME=3.7±0.7). However\, considering that the conduction mechanism of such OMEs is through electron hopping\, where electrons are localized\, these results do not contradict the literature. \nI have also studied the cable bacteria\, especially the fibers that are along this filamentous bacterium. The dielectric constant of the fibers was εr=7±1. This result is not compatible with the conductivity reported in the literature. Therefore\, a core-shell model was proposed with a conductive core of h~10–20nm. \nSubsequently\, I have performed qualitative EFM measurements in liquid over living and rehydrated S. oneidensis bacteria. \nFinally\, I have performed macroscale measurements in living S. oneidensis using a microfluidic device that I designed\, fabricated and characterized at the Denmark Technical University (DTU)\, Copenhagen. It was used to perform two-electrode impedance measurements. \n\nIn order to attend to the defense\, you must send an email to the president of the Doctoral Commission of the Faculty of Physics (Dr. Eugeni Grauges Pous – vd.fisica.recerca@ub.edu) with a minimum notice of 48 hours and will be held via Microsoft Teams.
URL:https://ibecbarcelona.eu/event/75980/
CATEGORIES:PhD Thesis Defence
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