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DTSTART;TZID=Europe/Madrid:20210407T100000
DTEND;TZID=Europe/Madrid:20210407T120000
DTSTAMP:20260408T141132
CREATED:20210326T095201Z
LAST-MODIFIED:20210326T095226Z
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SUMMARY:PhD Thesis Defence: Patrica Prado Peralta
DESCRIPTION:Developing new strategies to understand human kidney development and target human disease\nPatricia Prado Peralta\, Pluripotency for organ regeneration group \nThe defence will take place online using the BBCollab platform
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-patrica-prado-peralta/
CATEGORIES:PhD Thesis Defence
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210416T100000
DTEND;TZID=Europe/Madrid:20210416T120000
DTSTAMP:20260408T141132
CREATED:20210329T143157Z
LAST-MODIFIED:20210407T090510Z
UID:83098-1618567200-1618574400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Núria Montserrat
DESCRIPTION:Study on the of the interplay between glucose metabolism and SARS-CoV-2 infection exploiting human kidney organoids\n \nNúria Montserrat\, group leader “Pluripotency for organ regeneration” at IBEC \nSevere acute respiratory syndrome 2 (SARS-CoV-2) infection leads to a high risk of hospitalization and mortality in diabetic patients. SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) receptor\, which is expressed in key metabolic organs such as pancreas\, muscle\, heart\, adipose tissue\, the small intestine\, and the kidneys. As a result\, it is likely that SARS-CoV-2 may cause alterations of glucose metabolism that could complicate the pathophysiology of pre-existing diabetes or lead to new mechanisms of disease. \nThanks to an international collaboration we have previously shown that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids. In these last months we have started to collectively addressed how to study on the interplay between glucose metabolism and SARS-CoV-2 infections making use of kidney organoid technology. We have first developed culture regime conditions in human kidney organoids mirroring cellular responses similar to those encountered in the human diabetic kidney. Through an exhaustive characterization including single cell RNA profiling and ulterior validation in organoids and kidney patient cells we are starting to dissect the different transcriptional programs that are differently regulated in these different contexts. To further assess on the key role of ACE2 in these processes we have make use of CRISPR/Cas9 technology to generate human pluripotent stem cells lines knock out (KO) for ACE2. Kidney organoids ACE2KO have been further subjected to SARS-CoV-2 infections in normoglycemic and oscillatory glucose conditions further demonstrating the central role of ACE2 in early steps of infection in these organoid model systems. Thanks to our international collaborators we have also explored on the role of ACE2 in early steps of SARS-CoV-2 infection in other organoid platforms including gastric and vascular organoids. \nTogether\, our results provide evidence that SARS-CoV-2 infection altered glucose metabolism and support the use of kidney organoids as a platform to investigate the cellular susceptibility\, disease mechanisms\, and treatment strategies for SARS-CoV-2 infection in hyperglycaemic condition. \nMore information about Núria Montserrat’s research here \nThis seminar will be held using the GoToMeeting Platform
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-nuria-montserrat/
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210416T100000
DTEND;TZID=Europe/Madrid:20210416T120000
DTSTAMP:20260408T141132
CREATED:20210409T065700Z
LAST-MODIFIED:20210409T065700Z
UID:83305-1618567200-1618574400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Núria Blanco-Cabra
DESCRIPTION:Noves metodologies per al tractament de bacteris creixent en forma de biofilm\nNúria Blanco-Cabra\, Bacterial infections and antimicrobial therapies group at IBEC \nThe defence will take place online\, if you wish to attend to this defence\, write an email to doctoratmedicina@ub.edu at least 48 hours before the defence.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-nuria-blanco-cabra/
CATEGORIES:PhD Thesis Defence
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210426T100000
DTEND;TZID=Europe/Madrid:20210426T120000
DTSTAMP:20260408T141132
CREATED:20210422T071047Z
LAST-MODIFIED:20210422T071132Z
UID:83625-1619431200-1619438400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Laura Moya
DESCRIPTION:Deciphering the utility of Galleria mellonella as an infection and toxicity in vivo model\nLaura Moya\, Bacterial infections: Antimicrobial therapies \nThe defence will take place online\, if you wish to attend to this defence\, you will find the link to access and all the information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-laura-moya/
CATEGORIES:PhD Thesis Defence
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210430T100000
DTEND;TZID=Europe/Madrid:20210430T120000
DTSTAMP:20260408T141132
CREATED:20210419T121756Z
LAST-MODIFIED:20210420T103321Z
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SUMMARY:PhD Discussion Sessions: Teodora Andrian and Xavier Arqué
DESCRIPTION:Correlating super-resolution microscopy and transmission electron microscopy for nanoparticle characterisation\nTeodora Andrian\, Nanoscopy for nanomedicine group \nThe functionalization of nanoparticles with surface functional moieties is a key strategy to achieve bioactivity and cell targeting in nanomedicine. The interplay between size and ligand number and distribution is crucial for the formulation performance and needs to be properly characterized to understand nanoparticle structure-activity relations. However\, the particle-to-particle heterogeneity poses a serious challenge due to the lack of methods able to measure both size and ligand number and distribution at the same time and at the single particle level. Here we address this issue by introducing a correlative method combining super-resolution microscopy (SRM) and transmission electron microscopy (TEM) imaging. Correlative light and electron microscopy (CLEM) techniques proved their potential in structural biology but to the best of our knowledge\, they have not yet been explored for the structural characterization of nanoparticles. Here we apply our super-resCLEM method to characterize the relationship between size and ligand number\, and ligand density in PLGA-PEG nanoparticles at the single particle and single-molecule level.  We highlight how heterogeneity found in nanoparticle size can impact ligand distribution\, and we discuss the implications on formulation performance. We show how a significant part of the nanoparticle population goes completely undetected in the single-technique analysis\, demonstrating that the characterization of nanomaterials using a multiparametric correlative method outplays the information obtained compared to a one-method-at-a-time approach. Using SRM alone\, we demonstrated how PEG architecture can influence ligand conjugation efficiency and accessibility. The applicability of our method spans beyond PLGA-PEG nanoparticles and holds great promise for the multiparametric analysis of several other parameters and nanomaterials. \nUnraveling the fundamental aspects of enzyme-powered micromotors\nXavier Arqué\, Smart Nano-Bio-Devices group \nEnzyme-coated micro- and nanomotors self-propel by the biocatalytic conversion of substrates into products and show great promise as actively navigating agents in the fields of biomedicine and environmental applications. However\, many of the fundamental aspects underlying enzyme-powered self-propulsion have yet to be fully understood and are crucial for their optimal implementation. Under this framework\, this research is focused on elucidating and studying the intrinsic (catalytic turnover or structural flexibility) and extrinsic (bulk and local ionic media) enzymatic properties that lead to an improved active motion powered by bio-catalysis. This is enabled by exploring novel types of both i) enzymes that can act as active motion engines and ii) platforms with appealing properties to be used as chassis of enzymatic micro- and nanomotors. Overall\, this work contributes to a better understanding of the mechanism of motion of enzymatic active motion\, expands the current library of enzymatic engines and chassis materials available\, and provides new insights into the feasibility of implementation of enzyme-powered micro- and nanomotors. \nThe session will be held online using the GoToMeeting Platform
URL:https://ibecbarcelona.eu/event/phd-discussion-sessions-teodora-andrian-and-xavier-arque/
CATEGORIES:PhD Discussions Session
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