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DTSTART;TZID=Europe/Madrid:20211117T183000
DTEND;TZID=Europe/Madrid:20211117T193000
DTSTAMP:20260501T035311
CREATED:20211007T120350Z
LAST-MODIFIED:20211108T160240Z
UID:87683-1637173800-1637177400@ibecbarcelona.eu
SUMMARY:¡Adéntrate en la nano-escala: descubre y juega con el Microscopio de Fuerza Atómica! - Semana de la ciencia
DESCRIPTION:¡Adéntrate en la nano-escala: descubre y juega con el Microscopio de Fuerza Atómica!\n \nDesde que en la década de los 80 se inventara el microscopio de sonda de barrido\, han sido muchos y muy relevantes los descubrimientos que estas técnicas han proporcionado al conocimiento científico. Aun hoy\, es un instrumento capaz de detectar fenómenos increíbles que se dan en la escala de lo muy pequeño\, fenómenos que nos acercan más y más a la comprensión de este mundo sujeto a fuerzas muy distintas de lo cotidiano. \nEn esta charla con el investigador Rubén Millán del Instituto de Bioingeniería de Cataluña (IBEC)\, podréis descubrir cómo funciona un microscopio de AFM\, tendréis la posibilidad de probar en vivo el juego “Catch me AFM”\, y de conocer a nuestra superheroína científica IBBI. \n¡No os lo podéis perder! Inscripciones aquí. \n\nCharla divulgativa sobre la microscopia AFM en el marco de la “Setmana de la ciència 2021“
URL:https://ibecbarcelona.eu/event/adentrate-en-la-nano-escala-descubre-y-juega-con-el-microscopio-de-fuerza-atomica-semana-de-la-ciencia/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Outreach / Fair / Festival
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211118T180000
DTEND;TZID=Europe/Madrid:20211118T190000
DTSTAMP:20260501T035311
CREATED:20211108T152048Z
LAST-MODIFIED:20211108T152108Z
UID:88405-1637258400-1637262000@ibecbarcelona.eu
SUMMARY:La recerca en Parkinson
DESCRIPTION:Vine a l’IBEC durant la Setmana de la Ciència i podràs conèixer els últims avenços sobre la recerca en Parkinson\, visitar els nostres laboratoris i parlar amb els i les protagonistes d’aquesta recerca.\n\n\n\n\n\nEn el marc de la setmana de la ciència\, us convidem a una jornada de portes obertes on podreu visitar els laboratoris de la Professora Sílvia Muro\, investigadora ICREA a l’IBEC i responsable del projecte de recerca en Parkinson. \nMés informació sobre aquesta investigació aquí
URL:https://ibecbarcelona.eu/event/la-recerca-en-parkinson/
LOCATION:IBEC
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211119T100000
DTEND;TZID=Europe/Madrid:20211119T120000
DTSTAMP:20260501T035311
CREATED:20210901T151522Z
LAST-MODIFIED:20211110T120644Z
UID:86930-1637316000-1637323200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cristina Mayor-Ruiz
DESCRIPTION:Targeted protein degradation: genetic determinants and drug discovery opportunities\nCristina Mayor-Ruiz\, IRBarcelona \nTargeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are “molecular glue degraders”: compounds that can degrade otherwise unligandable proteins by orchestrating direct interactions between target and E3. However\, their discovery has been serendipitous\, thus hampering broad translational efforts. I will present a scalable target-agnostic strategy toward glue degrader discovery. This approach is based on differential chemical screening coupled to a multi-omics target deconvolution campaign. Collectively\, our data outline a versatile and broadly applicable strategy to identify degraders and thus empower future drug discovery efforts. \n\nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Cristina Mayor-Ruiz’s research here \nCristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of Óscar Fernández-Capetillo. There\, she explored mechanisms of resistance to anticancer therapies. In 2018\, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships\, where her interests focused on different aspects of chemical biology and drug screening. Since January 2021\, she leads the “Targeted Protein Degradation & Drug discovery” lab at IRB Barcelona. Her research focuses on: \n(1) Developing screening strategies for early drug discovery. In particular\,  to identify monovalent degraders and other proximity-inducing drugs with therapeutic interest. \n(2) Tackling exciting biological questions that either benefit from the high kinetic resolution provided by targeted protein degradation\, or that involve E3 (dys)regulation dynamics. \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-cristina-mayor-ruiz/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211126T100000
DTEND;TZID=Europe/Madrid:20211126T120000
DTSTAMP:20260501T035311
CREATED:20210909T094150Z
LAST-MODIFIED:20211117T150528Z
UID:87087-1637920800-1637928000@ibecbarcelona.eu
SUMMARY:PhD Discussions: Yolanda Castillo and Marc Molina
DESCRIPTION:Assessment of trunk function in patients with spinal cord injury using electromyography and smartphone accelerometry\nYolanda Castillo\, Biomedical Signal Processing and Interpretation \nSpinal cord injury (SCI) causes motor and sensory impairment below the level of the injury\, but also many other health problems. A common consequence of SCI is the lack of control over trunk muscles\, leading to deficits in postural control and balance while sitting. Since trunk stability is essential to maintain upright posture and support functional movements\, impaired trunk function constitutes a major cause of motor disability in SCI patients\, limiting their independence and quality of life. However\, trunk stability is rarely examined in studies of mobility after SCI\, and one of the reasons is the lack of quantitative measures for assessing trunk function. Here we propose to record and analyze electromyographic (EMG) and smartphone accelerometric data to extract quantitative measures for the evaluation of trunk function. Our aims were: 1) to characterize muscle activity and movement patterns of trunk flexion during a reaching task in healthy subjects and patients with SCI\, 2) to compare the impact of cervical and thoracic injuries in trunk function\, and 3) to investigate the potentially destabilizing effects of a startling acoustic stimulus in this task. For these purposes\, during a reaching movement requiring trunk flexion\, we recorded the EMG activity of 8 trunk\, neck\, and shoulder muscles and smartphone accelerometer data from individuals with cervical SCI\, thoracic SCI\, and healthy control subjects. We analyzed these signals and extracted different features\, including the response time until pressing a target button\, EMG onset latencies and amplitudes\, and trunk tilt\, lateral deviation\, and other movement features from accelerometry. The proposed outcome measures revealed deficits in postural control and compensatory strategies employed by SCI patients\, including delayed responses and higher lateral deviations\, which might have important consequences for rehabilitation. The combination of EMG and smartphone accelerometer data can help to develop more suitable methods for the assessment of trunk function in individuals with SCI\, thus improving the follow-up and management of these patients. \nDevelopment of a model of “macro” substrates for the analysis of 3D chromatin structure and transcriptional profiling\nMarc Molina\, Cellular and Molecular Mechanobiology \nMechanically-induced changes in the genome are increasingly recognized as major drivers of cell and tissue function. However\, current and past studies on this topic in vitro have often been limited by the sample size required for these genomic analyses. Here we describe the development of a polyacrylamide gel (pAAg) substrate with larger area than gels previously generated in labs worldwide. These substrates display the same tunable stiffness as their smaller counterparts and are particularly suitable to accommodate large numbers of cells. We tested the substrates to assess the effect that changes in rigidity have in the cell’s genome\, both at the level of chromatin organization and transcriptional regulation. For this\, two different rigidities were used (soft vs stiff) with three conditions which included: i) a control group\, ii) a transiently expressing mutant of RanQ69L that prevents all nucleocytoplasmic transport and iii) a transiently expressing mutant of NES1-KASH that prevents force transmission to the nucleus. Our preliminary results suggest that cells seeded on pAAg substrates of different rigidities display differences in chromatin structure and gene expression\, but more data will be necessary to further support these results. Ultimately\, the aim of our project is to understand down the road how changes in rigidity affect: i) the 3D structure and interaction map of chromatin and ii) the activated or repressed transcriptional programs in soft and stiff substrates. Overall\, this new model will help us to characterize how the genome is affected by rigidity both at the structural and transcriptional levels. More broadly\, we expect the potential findings of this work to help the community detailing the effect of changes in tissue stiffness in the genome spatial organization. \nThis PhD Discussion will be hybrid. Yolanda Castillo will be doing her presentation online and Marc from the Baobab room\, located in tower I floor 11. To follow the session online\, find here the link\, we will be using the GoToMeeting app. If you wish to attend in person\, the free spots will be assigned on a first come first served basis\, the capacity of the room is for 30 people.
URL:https://ibecbarcelona.eu/event/phd-discussions-yolanda-castillo-and-marc-molina/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211130T160000
DTEND;TZID=Europe/Madrid:20211130T170000
DTSTAMP:20260501T035311
CREATED:20211110T120518Z
LAST-MODIFIED:20211124T114657Z
UID:88450-1638288000-1638291600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rob Jelier
DESCRIPTION:The effect of gene loss on adaptation | 3D cell shape analysis in embryos\nRob Jelier\, CMPG – Predictive Genetics and Multicellular Systems University of Leuven \nIn this talk I will summarize two research projects. First\, I will report on a large-scale experimental evolution study into the effect of gene deletion on adaptation. We found gene deletion can speed up adaptation. Further\, tracking adaptation after the systematic perturbation of genes involved in a complex trait informs on the genetic architecture of the trait. Second\, we have developed a segmentation-pipeline for membrane tagged cells from fluorescent microscopy timelapses. The pipeline uses a biophysical DEM model of cell shape to constrain the possible cell shapes. The retrieved accurate cell shapes are subsequently used for very sensitive characterization of cell shapes\, for example to identify changes after perturbations. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu.
URL:https://ibecbarcelona.eu/event/ibec-seminar-rob-jelier/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
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