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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20230111T120000
DTEND;TZID=Europe/Madrid:20230111T130000
DTSTAMP:20260407T221004
CREATED:20230109T085957Z
LAST-MODIFIED:20230109T102957Z
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SUMMARY:IBEC Seminar: Manuel Valero
DESCRIPTION:The role of inhibition in hippocampal coding\nManuel Valero\, PhD NYU Neuroscience Institute\, New York University (US) \nThe fundamental computation a single neuron performs is to integrate incoming excitatory and inhibitory inputs to decide whether to fire an action potential and feedback its activity into the network. Investigation of this synaptic computation requires access to the neuron subthreshold dynamics\, whose state-of-art methodologies have remained unaltered for decades and are unrealistic for cell assemblies and behaving animals.\nInstead of intracellular recording\, we propose a method to optogenetically probe the membrane polarization of the cells with short depolarizing pulses using chronically implanted µLED probes (4 shanks with 3 µLED/shank). Light-sensitive neurons responded to one or more µLEDs and the spike numbers were used as a proxy for estimating relative changes in the membrane potential dynamics. Strikingly\, induced spike responses gain sharply increased several-folds inside the preferred position (place fields) of the responsive cells. These results are compatible with a tuning curve model in the CA1 pyramidal cells where excitation and inhibition display a concerted and reciprocal relationship. When optogenetic stimulation was probed on non-place cells\, majority of the putative non-place cells showed place-related activity. Finally\, we optically probed neurons around sharp wave-ripples (SPW-Rs)\, hippocampal events considered a key mechanism for memory consolidation and action planning. In the short time window of SPW-R\, excitatory and inhibitory neurons increased in parallel. As expected\, optogenetic probing of the CA1 networks showed that\, in contrast to the large gain within place fields\, responsivity of pyramidal cells showed a robust decrease during SPW-Rs.\nWe have developed a method for studying the subthreshold dynamics of individual cells in chronic recordings using novel high-resolution optical stimulation as a proxy for membrane polarization. These experiments disclosed a reciprocal interaction between inhibition and excitation along the place fields of CA1 and demonstrated that the same exact perturbation can bring about opposite responses during exploration and transient SPW-Rs. \n\n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-manuel-valero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230112T150000
DTEND;TZID=Europe/Madrid:20230112T170000
DTSTAMP:20260407T221004
CREATED:20230109T120957Z
LAST-MODIFIED:20230109T120957Z
UID:103511-1673535600-1673542800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Granero Moya
DESCRIPTION:STUDY OF THE EFFECTS OF MECHANICAL FORCE ON NUCLEO-CYTOPLASMIC TRANSPORT\n\n\n\n\nAuthor: Ignasi Granero Moya\, Cellular and molecular mechanobiology\n\n\nThis thesis defence will take place at “Facultat de Medicina de la UB (Hospital Clínc)” at 15:00. Room to be determined.\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ignasi-granero-moya/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230118T120000
DTEND;TZID=Europe/Madrid:20230118T140000
DTSTAMP:20260407T221004
CREATED:20230112T111150Z
LAST-MODIFIED:20230112T111309Z
UID:103534-1674043200-1674050400@ibecbarcelona.eu
SUMMARY:IRB Research Node/IBEC Joint Seminar:  Jolanda van Leeuwen
DESCRIPTION:Date: Wednesday 18 January 2023\, 12:00h\nPlace: Audiorium Room\, PCB \nSpeaker: Jolanda van Leeuwen\, University of Lausanne\, Lausanne\, Switzerland \nTitle:  Systematic analysis of genetic suppression interactions \nHost: Patrick Aloy (IRB) & Benedetta Bolognesi (IBEC) \nAbstract: \nRecent genome sequencing efforts have identified people that are healthy despite carrying mutations that have been directly associated with severe early-onset Mendelian diseases. These resilient individuals may carry secondary mutations elsewhere in the genome that can compensate for the deleterious effect of the disease-associated mutation\, a phenomenon referred to as genetic suppression. Identification of the protective mutations could highlight strategies for therapeutic intervention\, but we currently lack the expertise to identify the suppressor mutations among the millions of variants scattered across the genomes of resilient individuals. \nI will discuss how we use systematic genetic suppression interaction screens in the budding yeast and cultured human cells to dissect gene function and pathway connectivity\, and to define conserved properties of genetic suppression that we can use to predict suppression interactions between genomic variants across species.
URL:https://ibecbarcelona.eu/event/irb-research-node-ibec-joint-seminar-systematic-analysis-of-genetic-suppression-interactions/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:Joint seminar / workshop / symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230119T093000
DTEND;TZID=Europe/Madrid:20230119T113000
DTSTAMP:20260407T221004
CREATED:20230112T111707Z
LAST-MODIFIED:20230112T111707Z
UID:103539-1674120600-1674127800@ibecbarcelona.eu
SUMMARY:IRB Research Node/IBEC Joint Seminar: Nunilo Cremades
DESCRIPTION:Date: Thursday 19 January 2023\, 9:30h\nPlace: Felix Serratosa Hall\, PCB \nSpeaker: Nunilo Cremades\, PhD – Associate Professor at Dept. Biochemistry and Molecular and Cellular Biology and Group Leader at Institute for Biocomputation and Physics of Complex Systems (BIFI)\, University of Zaragoza\, Spain \nTitle:  Liquid-liquid phase separation and co-aggregation of neurodegenerative disease-related alpha-synuclein and Tau proteins \nHost: Xavier Salvatella (IRB) & Benedetta Bolognesi (IBEC) \nAbstract: \nSpatial segregation in the cell can be achieved through the formation of protein-rich liquid-like dense bodies\, termed biomolecular condensates or liquid droplets\, through a process known as liquid-liquid phase separation (LLPS). Emerging evidence supports the hypothesis that aberrant protein-driven LLPS and the transition of the liquid droplets to solid-like structures might be a relevant cellular pathway leading to the formation of amyloid\, toxic aggregates that are often a hallmark of relevant neurodegenerative diseases. A number of experimental studies have highlighted the flexible\, typically disordered and ‘multivalent’ nature of the constituent proteins in these liquid-like condensates\, although less is known about the particular molecular determinants governing the growth and maturation of these condensates into more solid-like states. While the LLPS process of Tau\, the protein that is generally associated with Alzheimer´s disease\, has been recently clarified\, that of alpha-synuclein (αS)\, the protein linked to Parkinson´s disease\, remains obscure. In this talk\, I will show our recent findings that demonstrate that αS actively phase-separates into liquid condensates by electrostatic complex coacervation with positively charged polypeptides such as Tau. By combining a set of advanced biophysical techniques\, we have been able to characterize αS/Tau LLPS and identified key factors leading to the co-aggregation of both proteins inside the coacervates. The mechanism of co-aggregation between αS and Tau that we have identified could be the basis for the in vivo formation of αS/Tau hetero-aggregates observed in the brains of patients suffering from synucleinopathies.
URL:https://ibecbarcelona.eu/event/irb-research-node-ibec-joint-seminar-nunilo-cremades/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Joint seminar / workshop / symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230120T100000
DTEND;TZID=Europe/Madrid:20230120T120000
DTSTAMP:20260407T221004
CREATED:20230109T095712Z
LAST-MODIFIED:20230109T095712Z
UID:103484-1674208800-1674216000@ibecbarcelona.eu
SUMMARY:IBEC Seminar (online): Sam Hall
DESCRIPTION:Presentation of Open Research Europe publishing plataform\nSam Hall\, from Open Research Euorpe \nOpen Research Europe is the European Commission’s open access publishing platform for research stemming from Horizon 2020 and Horizon Europe funding. In this webinar Senior Content Acquisition Editor Sam Hall will show how the platform enables the rapid dissemination of results and facilitates open and constructive research discussion\, and maximizes the discoverability and credit for researchers and their work. Sam will also explain the funder-pays model which means that all publication fees are met by the European Commission at no cost to the researcher or the project. \n\nSam Hall is a Senior Content Acquisition Editor for F1000\, commissioning articles and Collections for Open Research Europe. Launched in March 2021\, Open Research Europe is an open access publishing Platform for research stemming from Horizon 2020\, Horizon Europe and/or Euratom funding across all subject areas. Within this broad remit\, Sam focusses on the research area of Engineering and Technology\, and most recently the Data Note article type. Sam has almost 10 years of experience working in publishing\, and in this time has worked in contrasting companies and settings. This has included society publishers\, start-ups\, and international governmental organizations. \nLink Teams here
URL:https://ibecbarcelona.eu/event/ibec-seminar-online-sam-hall/
LOCATION:Online
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20230124T110000
DTEND;TZID=Europe/Madrid:20230124T130000
DTSTAMP:20260407T221004
CREATED:20230102T141828Z
LAST-MODIFIED:20230102T141828Z
UID:103359-1674558000-1674565200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xavier Arqué
DESCRIPTION:Unraveling the Fundamental Aspects of Enzyme-powered Micromotors\n\n\n\n\nAuthor: Xavier Arqué\, Smart Nano-Bio-Devices Lab\n\nThis thesis defence will take place at “Aula Magna” Building A\, Faculty of Pharmacy\,\nUniversity of Barcelona (Campus Diagonal\, Av. de Joan XXIII\, 27-31\, 08028 Barcelona) at 11:00\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xavier-arque/
LOCATION:Aula Magna\, Faculty of Pharmacy\, Av. Joan XXIII s/n\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
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