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DTSTART;TZID=Europe/Madrid:20230413T150000
DTEND;TZID=Europe/Madrid:20230413T170000
DTSTAMP:20260408T091129
CREATED:20230328T155642Z
LAST-MODIFIED:20230328T155642Z
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SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:Engineering the cancer: from biomaterials to on-chip solutions\nDavid Caballero; Research Institute on Biomaterials\, Biodegradables and Biomimetics\, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine\, University of Minho\, Portugal. \nCancer is a complex and multifaceted pathology\, which is influenced by numerous factors\, including the tumor microenvironment (TME). This environment is composed of various of components that interact in a tightly regulated manner\, affecting cancer cell behavior and response to treatment. Building realistic models of the TME is therefore essential for improving our knowledge of cancer pathophysiology and developing more effective therapies. In recent years\, there has been growing interest in using precisely-engineered biomaterials and microphysiological systems to create accurate 3D in vitro models of the TME. These models can provide a more physiologically-relevant habitat for studying fundamental aspects of cancer biology and for performing drug screening. Additionally\, when combined with organ-on-a-chip technology\, these models offer a high degree of biomimicry and control\, allowing for a precise recreation and better understanding of key biological functions of the native TME\, surpassing what traditional platforms can achieve. In this lecture\, I will present our latest works utilizing biomimetic materials and on-chip systems as powerful preclinical tools for engineering realistic in vitro models of the TME to study key aspects of tumorigenesis\, for drug screening/discovery purposes\, and for disease diagnosis applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-caballero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230421T093000
DTEND;TZID=Europe/Madrid:20230421T140000
DTSTAMP:20260408T091129
CREATED:20230309T170353Z
LAST-MODIFIED:20230309T170353Z
UID:105706-1682069400-1682085600@ibecbarcelona.eu
SUMMARY:Course · Inclusive Science; attention to diversity in science education projects
DESCRIPTION:This course aims to promote inclusive education in scientific education activities in non-formal settings\, guaranteeing access to scientific culture for all children and adolescents\, regardless of their learning needs. \nDuring the course\, general guidelines and guidelines will be presented to accompany students with visual disabilities\, as well as practical examples of STEAM activities. Accessibility and digital usability will also be addressed and tools will be offered to contribute to access to information for students with visual disabilities. \nThis course is organized by the Bioengineering Institute of Catalonia (IBEC) in collaboration with ONCE. \n  \nRegistration is required here.
URL:https://ibecbarcelona.eu/event/course-%c2%b7-inclusive-science-attention-to-diversity-in-science-education-projects/
LOCATION:Centro de Recursos Educativos ONCE Barcelona\, Gran Vía de les Corts Catalanes\, 394\, Barcelona.
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230426T110000
DTEND;TZID=Europe/Madrid:20230426T110000
DTSTAMP:20260408T091129
CREATED:20230412T131424Z
LAST-MODIFIED:20230412T131618Z
UID:107088-1682506800-1682506800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Ubaka Ogbogu
DESCRIPTION:Foregrounding justice\, equity and inclusion as determinants of access to precision medicine: an ethical case study of patient-derived tissue organoids.\nDr. Ubaka Ogbogu\, Professor and the Associate Dean Research in the Faculty of Law from the University of Alberta\, Canada.  \nUbaka Ogbogu is a Professor and the Associate Dean Research in the Faculty of Law. He is also the Chair of the University of Alberta Research Ethics Board 2 and the Katz Research Fellow in Health Law and Science Policy. Dr. Ogbogu is a recipient of the Confederation of Alberta Faculty Associations Distinguished Academic Early Career Award. He holds a doctorate in law from the University of Toronto\, a Master of Laws degree from the University of Alberta and undergraduate degrees in law from the University of Benin\, Nigeria and the Nigerian Law School. \nOgbogu’s scholarly work is focused broadly on the ethical\, legal and societal implications of novel and emerging biotechnologies and associated research. His publications have explored a diverse range of issues in this field\, including the ethical and legal issues associated with stem cell research\, gene and engineered cell therapies\, biobanks\, germline gene editing. In his talk\, Prof. Obgobu will reflect about these issues and also discuss how foregrounding justice\, equity and inclusion are elements that impact on access to precise medicine. \nHe has been invited to IBEC by Nuria Montserrat. \n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ubaka-ogbogu/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T100000
DTEND;TZID=Europe/Madrid:20230428T110000
DTSTAMP:20260408T091129
CREATED:20230420T113916Z
LAST-MODIFIED:20250306T162535Z
UID:107325-1682676000-1682679600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Ainoa Tejedera and Zarina Nauryzgaliyeva
DESCRIPTION:Mimicking Sarcolemmal Damage In vitro: A 3D Skeletal Muscle Model for Drug Testing in Duchenne Muscular Dystrophy\nAinoa Tejedera Villafranca\, Biosensors for bioengineering group \nDuchenne muscular dystrophy (DMD) is the most prevalent neuromuscular disease diagnosed in childhood. It is a progressive and wasting disease\, characterized by a degeneration of skeletal and cardiac muscles caused by the lack of dystrophin protein. The absence of this structural protein leads to the fragility of the sarcolemma\, and muscle fibers are damaged during their contraction. To date\, there is no cure available for patients\, even though there are several molecules in drug development. However\, due to the well-known limitations of preclinical research\, the success rate of drugs remains low. In this work\, intending to accelerate drug discovery for DMD\, we developed a patient-derived functional 3D model of DMD. By using a 3D-printed casting mold\, we encapsulated muscle progenitor cells in a fibrin-composite matrix. This platform incorporates two flexible T-shaped pillars that serve as anchoring points and provide continuous tension to the tissue\, thus allowing the orientation of the muscle fibers. The skeletal muscle tissues expressed mature myogenic markers and showed functional phenotypes as they responded to electrical pulse stimulation (EPS) by contracting. We observed that DMD muscle tissues\, after continuous contractile regimes\, reproduced the loss of myotube integrity that is observed in dystrophinopathies due to the sarcolemmal instability. DMD but not healthy tissues showed functional phenotypes caused by the induced sarcolemmal damage\, such as tetanic fatigue. Finally\, the applicability of this DMD model in evaluating therapeutic compounds was explored. Specifically\, we investigate the effect of utrophin up-regulators on functional outcomes of the model\, thus identifying potential candidates for the treatment of DMD. Taking all these considerations together\, our results show that bioengineered 3D skeletal muscle technology has great potential to be especially valuable in the context of current and future discovery and development of drugs to treat DMD and other neuromuscular disorders. \n\nDissecting early nephron patterning and segmentation in kidney organoids derived from hPSCs\nZarina Nauryzgaliyeva \, Pluripotency for organ regeneration Group \nThe formation and maturation of organs during development is a complex\, yet beautifully orchestrated process. Embryonic cells have a unique capacity to self-organize within the forming tissue\, where morphogenetic movements have been shown to facilitate tissue organization and subsequent organ formation. In kidney organogenesis\, the mature organ arises from crucial reciprocal interactions between the ureteric bud (UB) and metanephric mesenchyme (MM)\, which give rise to the collecting duct and nephron\, respectively. The development of mature nephrons during kidney organogenesis is a dynamic process so far studied taking advantage of in vivo models. Accumalative findings in mice have shown that the MM undergoes mesenchymal to epithelial transition (MET)\, giving rise to epithelial renal vesicles (RVs) that further undergo structural changes and shift towards comma shaped and s-shaped bodies (CSBs/SSBs)\, which eventually develop into nephron like structures. Those studies have helped identify Wnt/b-catenin and Notch signalling pathways as key players in nephron patterning and segmentation (proximal\, medial\, distal segments).\nAt the same time\, tissue morphogenesis is largely a biomechanical process\, resulting from constant movements of cells\, changes in forms of developing segments and forces generated therein. The biomechanical dynamics occurring during RV emergence and further nephron patterning are yet to be explored in the human context in real time. If these biomechanical processes are interconnected with mechanical signals remains an open question in the field. The answer to these questions may have an important impact for understanding nephron formation\, and conversely\, disease-related phenotypes due to mutations in genes orchestrating RV patterning and segmentation as occurs in congenital defects of the kidney and the urinary tract (CAKUT disease).\nHere\, we aim to use human pluripotent stem cell (hPSCs) derived kidney organoids to gain fundamental understanding of early nephron patterning and segmentation by mapping force transmission between cells and their extracellular matrix (ECM) and evaluating their co-evolution during renal fate specification and differentiation.\nhPSCs are guided towards the renal fate on compliant PDMS hydrogels with controlled rigidities (mimicking embryonic microenvironment) in a 2D culture system. PDMS hydrogels between 3 kPa (soft) and 18 kPa (rigid) are generated by adapting the compositional ratio of PDMS components and are further functionalized and decorated with fibronectin. Using this system\, we have started to spatiotemporally characterise early steps of nephrogenesis by immunofluorescence and confocal analysis\, time-lapse imaging\, and traction force microscopy (TFM). These analyses are nowadays conducted during RV emergence prior proximal-distal RV polarization and formation of the nephron-like segments.\nThe current techniques will permit quantitative and qualitative observations of multicellular behaviours at key stages of 2D renal differentiation. Furthermore\, this system will allow us to spatiotemporally map cell-cell and cell-ECM forces and evaluate their evolution throughout renal fate specification with the final aim to decouple mechano-related processes sustaining nephron formation from classical biochemical signalling. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am. \n  \nWith the support of Joan Oró grant to hire research staff in training (FI 2025)\, 2023 FI-2 00386\, funded by Generalitat de Catalunya and by the European Social Fund Plus. \n \n 
URL:https://ibecbarcelona.eu/event/phd-discussions-ainoa-tejedera-and-zarina-nauryzgaliyeva/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T120000
DTEND;TZID=Europe/Madrid:20230428T133000
DTSTAMP:20260408T091129
CREATED:20230309T155632Z
LAST-MODIFIED:20230426T104601Z
UID:105698-1682683200-1682688600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Charles Baroud
DESCRIPTION:Modeling immune-cancer interactions using a microfluidic 3D culture approach\nCharles Baroud\, Professor at Ecole Polytechnique\, France\nLab head at Institut Pasteur\, Paris\, France \nCancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach\, which has shown some remarkable successes\, leverages the patient’s own immune cells to locate and attack the tumor cells. However the method suffers from large heterogeneities in outcomes between different patients\, in part due to the the number\, phenotype\, and distribution of cytotoxic T cells (CTLs) around the tumor cells. For this reason decoding the collective behavior of CTLs\, as they recognize and attack cancer cells\, is a major challenge that requires advanced in vitro models. This seminar will present a microfluidic platform that enables quantitative measurements of the spatiotemporal dynamics of individual CTLs as they migrate in three-dimensional (3D) environments and attack cancer spheroids. The method provides access to the trajectories of thousands of cells around hundreds of spheroids\, which in turn enables probabilistic modeling of the trajectories. Analysis of the migration and killing events allows us to dissect the different phases of interactions and to identify limiting steps for different conditions. The talk will present the microfluidics and then shift focus to different biological models\, with implications for both fundamental biology and for personalized medicine. \n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-charles-baroud/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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