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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230606T093000
DTEND;TZID=Europe/Madrid:20230606T110000
DTSTAMP:20260408T055621
CREATED:20230503T152810Z
LAST-MODIFIED:20230503T152810Z
UID:107647-1686043800-1686049200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Danny Hatters
DESCRIPTION:Protein interactions gone awry in neurodegenerative disease\nDanny Hatters\, Department of Biochemistry and Pharmacology | Faculty of Medicine\, Dentistry and Health Sciences\nThe University of Melbourne\,  Australia\n \nThe Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine principles governing how proteins inappropriately aggregate and new approaches with chemical reagents to monitor cysteine reactivity to probe changes in proteome foldedness and conformation. I will discuss recent findings from our laboratory that provide insight to the consequences of protein aggregation by globular proteins\, and how we can model the types of protein-protein interactions that are involved. I will also discuss how we can monitor changes in protein structure and function in response to stresses and stimuli\, and under conditions of disease in Huntington Disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-danny-hatters/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230606T150000
DTEND;TZID=Europe/Madrid:20230606T180000
DTSTAMP:20260408T055621
CREATED:20230523T080627Z
LAST-MODIFIED:20230523T080627Z
UID:108201-1686063600-1686074400@ibecbarcelona.eu
SUMMARY:Greening the lab: celebrating ibec's sustainable practices
DESCRIPTION:On 6th of June we will celebrate that we are the first research center in Spain to certify its laboratories as sustainable by My Green Labs. \nSince the publication of the IBEC Strategy to promote sustainability in research in 2021\, IBEC has been working to make the work in the labs and in the institute more sustainable. \nAll this work has been recently recognized by becoming the first research center in Spain to certify its laboratories as sustainable by My Green Labs. \nThe next 6th of June at 3pm\, we will celebrate this success and share our experience and best practices.  \nCome and join us at the PCB!
URL:https://ibecbarcelona.eu/event/greening-the-lab-celebrating-ibecs-sustainable-practices/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Other
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230607T090000
DTEND;TZID=Europe/Madrid:20230609T150000
DTSTAMP:20260408T055621
CREATED:20230427T075924Z
LAST-MODIFIED:20230427T075924Z
UID:107560-1686128400-1686322800@ibecbarcelona.eu
SUMMARY:Advanced Functional Polymers for Medicine 2023​ conference
DESCRIPTION:The purpose of the AFPM conference series is to strengthen the interactions within the community of chemists\, material engineers\, physicists\, biologists and clinicians in the development of Advanced Functional Polymers for Medicine. \nThe current status\, challenges and requirements for future developments of polymers for medicine are presented by leading experts. The conference provides an outstanding opportunity to help young scientists in their career development and offers them an interdisciplinary discussion forum within an exclusive circle. \nInformation\, programme\, and registration fee here.
URL:https://ibecbarcelona.eu/event/advanced-functional-polymers-for-medicine-2023-conference/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230609T100000
DTEND;TZID=Europe/Madrid:20230609T110000
DTSTAMP:20260408T055621
CREATED:20230529T161933Z
LAST-MODIFIED:20230529T161933Z
UID:108343-1686304800-1686308400@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills: From Lab to Clinic
DESCRIPTION:From Lab to Clinic: An Overview of IBEC’s Clinical Mentoring Programme\nDo you know what IBEC’s Clinical Mentoring Programme is about? Have you considered participating in it?\nIn this Complementary Skills session\, Anna Gassol and Georgina Sorrosal from Col·legi official de Metges (COMB) together with Cristina Arimany from the Strategic Initiatives department at IBEC will explain the basis of the program. Meritxell Serra Casablancas (Smart Nano-Bio-Devices Group) and Luisa Camerin (Nanoprobes and Nanoswitches Group) will share their experience as the first mentees participating in the programme.\nThis will also be a great opportunity to learn how the programme can help in the clinical translation of the work done at IBEC and answer any questions you may have about it.
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-from-lab-to-clinic/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230612T120000
DTEND;TZID=Europe/Madrid:20230612T130000
DTSTAMP:20260408T055622
CREATED:20230607T125347Z
LAST-MODIFIED:20230607T125558Z
UID:108508-1686571200-1686574800@ibecbarcelona.eu
SUMMARY:BIST Open Seminar: Roberta Croce
DESCRIPTION:Natural Strategies for Solar Light Harvesting\nProfessor of Biophysics\, Photosynthesis and Energy at Department of Physics of the Vrije Universiteit in Amsterdam. \nIn this presentation I will introduce the fundamental processes of light harvesting in photosynthetic organisms and discuss their remarkable abilities to adapt and acclimate to diverse light conditions. Photosynthetic organisms have evolved sophisticated strategies to capture and utilize solar energy efficiently\, allowing them to thrive in various environments. This presentation will delve into the mechanisms by which these organisms optimize their light-harvesting capabilities\, including pigment choice\, photoprotection\, and dynamic responses to changes in light quality and quantity.\nThe presentation will discuss key aspects of light harvesting\, such as the spectral tuning of pigments to match available light wavelengths and the regulation of energy flow to prevent damage caused by excess light. Additionally\, the remarkable acclimation abilities of photosynthetic organisms to gradual changes in light intensity will be explored\, highlighting their capacity to fine-tune their photosynthetic machinery for optimal performance under varying light conditions.\nBy examining the natural strategies employed by photosynthetic organisms\, this presentation aims to provide insights into the principles of solar light harvesting. Understanding these natural strategies offers valuable lessons for optimizing light-harvesting systems and harnessing solar energy in a sustainable and efficient manner. \n\nRoberta Croce studied chemistry at the University of Padova and completed her Ph.D. in Plant Biology/Biophysics at the University of Milano in 1998. After two postdoc periods in Germany (MPI Mulheim a.d. Rurh) and Italy (University of Verona)\, she got a permanent position at the Institute of Biophysics of the CNR. In 2006 she moved to the University of Groningen where she became associate professor in 2008. Since 2011 she is Professor of Biophysics\, Photosynthesis and Energy at Department of Physics of the Vrije Universiteit in Amsterdam. Her research focuses on the molecular mechanisms of photosynthesis\, using an integrated approach including molecular biology\, biochemistry and ultrafast spectroscopy. She published more than 180 scientific articles on the topic of photosynthesis. She is an elected member of the Royal Netherlands Academy of Arts and Sciences (KNAW) and the Royal Holland Society of Science and Humanity (KHMW). She is also a member of the Board of Reviewing Editors of Science and the Plant Cell\, and the recipient of several personal research grants. In 2022 she was elected president of the International Society of Photosynthesis.
URL:https://ibecbarcelona.eu/event/bist-open-seminar-roberta-croce/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:External symposium / conference / congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230619T123000
DTEND;TZID=Europe/Madrid:20230619T133000
DTSTAMP:20260408T055622
CREATED:20230502T111657Z
LAST-MODIFIED:20230607T134735Z
UID:107616-1687177800-1687181400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Amnon Buxboim
DESCRIPTION:How does ageing-related stiffening of brain tissue microenvironments affect the regenerative capacity of cns progenitor cells\nProfessor of biology and bioengineering\, the Hebrew University of Jerusalem\, Israel. \nAgeing-related stiffening of neuronal microenvironments in the brain generates potent signals that attenuate the regenerative capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate. We find that ageing drives substantial remolding of the nuclear lamina in OPCs\, in which A-type lamin levels increase and B-type lamin expression decreases. Owing to the ubiquitous role of lamins in anchoring mostly heterochromatic sections at the nuclear envelope known as lamina associated domains (LAD’s)\, we hypothesized that ageing effects are mediated via altered genomic organization and regulation. In this study\, we isolate OPCs from neonate and aged rats and study the effects of ageing-related tissue stiffening by designing and optimizing hydrogel-based matrices that mimic the extracellular elasticity and adhesion signals of neonate and aged microenvironments. Indeed\, the differences in cellular morphologies and lamina compositions between neonate and aged cells are recapitulated by matrix elasticity. To characterize differences in the structural organization of the nuclear lamina\, we combine high-resolution optical and electron microscopies and perform micropipette aspiration based rheology to define the viscoelastic properties of OPC nuclei within intact cells. LAD mapping is performed using optimized CUT&RUN assays that target endogenous lamin-B1\, thus avoiding the effects of ectopic expression of nuclear envelope proteins\, which is a prerequisite by standard methodologies. Downstream effects on transcriptional regulation are studied via single-cell RNA sequencing (scRNA-seq)\, thus providing insight into cell-to-cell variations. In summary\, our work-in-progress highlights the mechanobiological component of ageing on progenitor cells of the CNS that can stimulate potential therapeutic strategies. \n\nDr. Amnon Buxboim is a professor of biology and bioengineering\, the Hebrew University of Jerusalem\, Israel. Trained as a biophysicist\, he opened the Buxboim Lab for Mechanobiology in 2013. Dr. Buxboim research aims at understanding how physical and mechanical inputs combine with parallel signaling pathways to direct cell-fate decision-making processes. The Buxboim Lab studies oocyte maturation\, preimplantation embryo development\, stromal bone marrow immunomodulation\, and CNS stem/progenitor cell ageing. Dr. Buxboim also studies mechanisms of nuclear mechanotransduction\, as mediated via nuclear lamins and associated nuclear envelope proteins. The Buxboim Lab combines established assays\, advanced computational tools\, newly designed device-based technologies\, and integrates single-cell level genomics with micro-rheological measurements. Based on his research findings\, Dr. Buxboim develops assisted reproductive technologies to advance and improve medical care.
URL:https://ibecbarcelona.eu/event/ibec-seminar-amnon-buxboim/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230620T113000
DTEND;TZID=Europe/Madrid:20230620T133000
DTSTAMP:20260408T055622
CREATED:20230502T111443Z
LAST-MODIFIED:20230607T134316Z
UID:107614-1687260600-1687267800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Magali Suzanne
DESCRIPTION:Mechanical impact of cell delamination on tissue dynamics\, in developmental and tumoral contexts\nCentre de Biologie Intégrative\, CNRS/UMR 5088\, Université Toulouse III\, Toulouse\, France \nHow mechanical forces drive morphogenesis is a fundamental question in the field of biomechanics. Combining imaging\, genetics\, biophysical and modeling approaches\, we found that apoptotic cells\, far from being eliminated passively\, exert a force before dying and thus actively participate in tissue remodeling. This transient force\, generated in the depth of the epithelium\, constitute a mechanical signal involved in tissue folding. Comparing apoptotic cell dynamics to cells undergoing EMT\, we found that a very similar apico-basal force is generated at the onset of EMT.\nWe further deciphered how these forces are transmitted at the tissue scale through the characterization of a specific mechanical state favoring directional force transmission and developed a new method that offers the opportunity to extract automatically\, in strongly deformed epithelia\, a precise characterization of the spatial organization of a given cytoskeletal network combined to morphological quantifications in highly remodeled 3D epithelial tissues.\nIn parallel\, we turned to cancer mechanics\, focusing particularly in tumor progression. Cancer is a largely widespread pathology that corresponds to an overproliferation of cells that could finally invade others tissues. Tumors develop through three increasingly aggressive steps: (1) hyperplasia\, which corresponds to cells overproliferation; (2) dysplasia\, during which cells can acquire a more mesenchymal phenotype\, and finally (3) metastasis. Tumor development can be influenced by mutations but also by external factors\, such as extracellular matrix rigidity. However\, a comprehensive understanding of the intrinsic factors driving tumor evolution is still lacking. Our recent unpublished work identifies unexpected factors that could influence tumor development\, and more specifically the hyperplasia/dysplasia transition\, a critical step in tumor aggressiveness. This work highlights puzzling differences between developmental and tumoral mechanics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-magali-suzanne/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230620T150000
DTEND;TZID=Europe/Madrid:20230620T170000
DTSTAMP:20260408T055622
CREATED:20230619T071822Z
LAST-MODIFIED:20230619T071946Z
UID:108633-1687273200-1687280400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Nimesh Ramesh Chahare
DESCRIPTION:Mechanics of Epithelial tissue subjected to controlled pressure\n\n\n\n\nAuthor: Nimesh Ramesh Chahare\, Integrative Cell and Tissue Dynamics group\n\n\n\nBiography: \nNimesh Ramesh Chahare earned his bachelor’s degree in Mechanical Engineering from the National Institute of Technology\, Nagpur in 2014. He further pursued a master’s degree at the Indian Institute of Science\, Bengaluru\, completing it in 2016. In 2017\, he began his doctoral work in Barcelona\, under the guidance of Prof. Marino Arroyo at Universitat Politècnica de Catalunya\, and Prof. Xavier Trepat at the Institute of Bioengineering of Catalonia. Currently\, he is a PhD candidate in applied mathematics\, specializing in the study of the mechanics of epithelial tissue under controlled pressure. \nAbstract: \nEpithelial sheets form specialized 3D structures suited to their physiological roles\, such as branched alveoli in the lungs\, tubes in the kidney\, and villi in the intestine. To generate and maintain these structures\, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses\, viscoelasticity\, and luminal pressure remains poorly understood. To address this question\, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup\, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure\, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach\, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However\, under sudden pressure reductions\, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events. \n  \n\n\nReading date: 20/06/2023\nReading time: 15:00 \nReading place: Facultat de Matemàtiques i Estadística-Sala d’Actes FME\, Edifici U\, Campus Sud\nThesis director: ARROYO BALAGUER\, MARINO and TREPAT GUIXER\, XAVIER\nCommittee:\nPRESIDENT: TRIVEDI\, VIKAS\nSECRETARI: MUÑOZ ROMERO\, JOSE JAVIER\nVOCAL: SUZANNE\, MAGALI \n\n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-nimesh-ramesh-chahare/
LOCATION:acultat de Matemàtiques i Estadística-Sala d’Actes FME\, Edifici U\, Campus Sud
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230628T120000
DTEND;TZID=Europe/Madrid:20230628T130000
DTSTAMP:20260408T055622
CREATED:20230626T100738Z
LAST-MODIFIED:20230626T103836Z
UID:109214-1687953600-1687957200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Benjami Oller-Salvia
DESCRIPTION:Development of chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases\nDr. Benjami Oller-Salvia\, IQS \nIn our group we develop chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases. In the first part of the talk\, I will report our efforts toward developing strategies to construct conditionally-active biotherapeutics that target antigens considered undruggable. In the second part of the talk\, I will present our work on peptides for drug delivery across the blood brain barrier. There\, I will highlight the recent development of a new family of bicyclic brain shuttles and provide a hint toward new ways of exploring brain transport. .
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-benjami-oller-salvia/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230630T100000
DTEND;TZID=Europe/Madrid:20230630T110000
DTSTAMP:20260408T055622
CREATED:20230621T150854Z
LAST-MODIFIED:20230623T093647Z
UID:108921-1688119200-1688122800@ibecbarcelona.eu
SUMMARY:PhD Discussion: Isabela Fortunato y Marina Martinez
DESCRIPTION:Cell migration up and down fibronectin gradients\nIsabela Fortunato\, Integrative cell and tissue dynamics group \nThe ability of cells to perform directed migration is essential for biological processes\, such as tissue morphogenesis\, immune function\, and cancer invasion. Directed cell migration is often triggered by spatial gradients in the cellular environment (e.g.\, chemical gradients\, called chemotaxis\, substrate stiffness gradients\, called durotaxis\, or substrate-bound ligand gradients\, called haptotaxis). Haptotaxis has been described in vivo as an important phenomenon during physiological and pathological conditions. However\, the molecular and mechanical processes that drive this form of directed cell migration remain elusive. Moreover\, generating accurate and reliable gradients of immobilized protein in vitro has been challenging and makes it harder to study haptotaxis. Here\, we explore how cells sense and respond to gradients of immobilized proteins. We used a photopatterning technique to create well-controlled fibronectin gradients and we studied the migration of single mammary epithelial cells (MCF-10A). This approach allowed us to map cell migration velocity\, traction forces\, and actin cytoskeleton dynamics as a function of fibronectin density. We observed that cells respond to fibronectin gradients by an initial polarization towards higher protein density in the first hours of migration. Surprisingly\, after the initial polarization\, cells maintained their directionality even if they were submitted to a negative protein gradient. This suggests that cells adapt their polarity features to maintain the preexisting structures and organelles geometry towards low fibronectin regions until a limitation on creating new adhesions. In this work we find that one key adaptation mechanism is driven by the actin flows\, specifically the increase in actin polymerization velocity at the leading edge. Besides haptotaxis\, we foresee that these results will shed light on other forms of directed cell migration in which cells integrate several internal and external cues to orient themselves in physiological and pathological processes. \n\nLiving myocardial slices as a representative in vitro platform for translational cardiovascular disease\nMarina Martínez\, Biomaterials for Regenerative Therapies group \nCardiovascular diseases are the leading cause of global mortality\, accounting for nearly 45% of all deaths in Europe. Myocardial infarction (MI) is a prevalent condition\, where a region of the cardiac muscle undergoes ischemia and up to one billion cardiomyocytes die in just a few hours. The heart has a limited regenerative ability; consequently\, cardiomyocytes lost due to MI cannot be replaced. In this scenario\, researchers have investigated and developed alternative therapies to promote cardiac repair and regeneration. \nLactate\, an important metabolite during cardiogenesis and cardiac development\, has been recently described as a potential modulator of the phenotype of cardiac cells in vitro. These findings support a novel use of lactate for endogenous heart regeneration strategies. Nevertheless\, effectiveness of ongoing therapeutic approaches is dependent on the level of maturation of cardiac tissue. Hitherto\, the regenerative capabilities of lactate in mature cardiac tissue have not been described. In this work\, we used living myocardial slices (LMS) as a model of mature cardiac tissue. LMS are 300 μm-thick slices of living myocardium with conserved physiological structure and function. Human and rat adult LMS were treated with lactate to evaluate early cellular\, molecular\, and functionality changes related to myocardial reprogramming\, cardiac structural rearrangements\, and fibrosis. Moreover\, the effect of lactate was characterized in both healthy and injured adult myocardium. \nFunctionally\, (8 mM) lactate-treated healthy and pathological human LMS displayed an increase in contractility. Expression of fibrotic\, pluripotency transcription factors\, and cardiomyocyte markers were detected. Exposure of healthy rat LMS to higher concentrations of lactate (20 mM) did not affect LMS viability nor altered LMS contractile force\, while promoted LMS stiffening. In cryoinjured rat LMS\, lactate drastically increased contractility and altered tissue remodeling in the region bordering the injury. \nLMS provide a representative in vitro platform for translational cardiovascular research. By using LMS\, characterization of the effect of lactate in mature cardiac tissue has been achieved. Exogenous lactate enhanced cardiac function in both human and injured rat LMS. Upregulation of transcription factors and cardiomyocyte markers may suggest an effect on partial cardiomyocyte reprogramming that would counteract the effects of tissue stiffening. Altogether\, this study further supports the prospective use of lactate as a bioactive signal in new endogenous cardiac regeneration strategies. \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion-isabela-fortunato/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
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