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X-WR-CALNAME:Institute for Bioengineering of Catalonia
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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20230705T100000
DTEND;TZID=Europe/Madrid:20230705T110000
DTSTAMP:20260408T042942
CREATED:20230615T143306Z
LAST-MODIFIED:20230615T143306Z
UID:108630-1688551200-1688554800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Theodore Alexandrov
DESCRIPTION:Spatial single-cell metabolomics reveals metabolic cell states\nEMBL \nRecent discoveries put metabolism into the spotlight. Metabolism not only fuels cells but also plays key roles in health and disease. In parallel\, emerging single-cell technologies opened a new world of cell types and states previously hidden beneath population averages. Yet\, methods for discovering links between metabolism\, cell states\, metabolic plasticity and reprogramming on the single-cell level and in situ are crucially lacking. Our research aims to contribute bridging this gap. First\, we will present how the emerging technology of imaging mass spectrometry can be used for the spatial profiling of metabolites\, lipids\, and drugs in tissues. These efforts are enabled by our big data community cloud platform METASPACE which is increasingly used across the world. Next\, we will present method SpaceM for spatial single-cell metabolomics. SpaceM detects 100+ metabolites or 500+ lipids from thousands of individual cells together with fluorescence and morpho-spatial features. We used SpaceM to characterize how stimulating human hepatocytes with fatty acids led to the emergence of two co-existing subpopulations outlined by distinct cellular metabolic states. Inducing inflammation with the cytokine IL-17A perturbs the balance of these states in a process dependent on NF-κB signalling. We will show how a high-throughput version of the SpaceM method helps discover and characterize metabolic states of activated CD4+ T cells from peripheral human blood. Finally\, we will present how spatial multi-omics can reveal the relationships between cell types and cell states in tissues. Overall\, such methods can open novel avenues for understanding metabolism in tissues and cell cultures on the single-cell level.
URL:https://ibecbarcelona.eu/event/ibec-seminar-theodore-alexandrov/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230712T120000
DTEND;TZID=Europe/Madrid:20230712T130000
DTSTAMP:20260408T042942
CREATED:20230705T112820Z
LAST-MODIFIED:20230705T112820Z
UID:109532-1689163200-1689166800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Loris Rizzello
DESCRIPTION:Towards an evolutionary-driven universal therapy against (intracellular) pathogens\nUniversità degli Studi di Milano \nWe are living a time where we believe antibiotics are the cornerstone of any infectious disease-based therapy. It is definitely out of question that antibiotics saved millions of people worldwide in the last century\, and that they are still doing it very efficiently. Nevertheless\, their extensive abuse\, especially for zoonic applications\, contributed to the rise of antibiotic resistance (AMR). AMR is one of the biggest threats in the current human history because it is estimated that the majority of the antibiotics\, currently used in the clinics\, will be completely ineffective for the eradication of infectious disease. This has been defined as “The New Dark Ages of Antibiotics”\, which is expected to start in the next decades if no actions will be taken now. There are several causes behind AMR\, but one of the most relevant is the exposure of bacteria to sub-lethal doses of the antimicrobials. One of the big aim of our research efforts is to design of a new generation of therapy that counteract this issue. It is inspired on solutions already provided by Nature\, and it is based on the strategy exploited by a specific class of viruses that infect and kill bacteria only\, called as bacteriophages\, which are completely safe and unharmful to humans. The development of a new therapy possessing the requirements to avoid the rise in AMR represents a new legacy for the future generation in terms of anitibacterial therapies\, exaclty in the same way antibiotics changed the human history in the 20th century.
URL:https://ibecbarcelona.eu/event/ibec-seminar-loris-rizzello/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230712T150000
DTEND;TZID=Europe/Madrid:20230712T170000
DTSTAMP:20260408T042942
CREATED:20230705T111505Z
LAST-MODIFIED:20230706T123428Z
UID:109529-1689174000-1689181200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Zev Gartner
DESCRIPTION:Building tissues to understand how tissues build themselves\nZev Gartner\, UCSF \nCells assemble into tissues and organs through an active process termed self-organization. Harnessing tissue self-organization will ultimately advance applications as diverse as disease modeling and regenerative medicine\, while revealing new strategies for fighting disease. However\, progress towards these applications is limited by our incomplete understanding of how the properties of tissues emerge from their cellular building blocks.  I will discuss two recent projects that aim to address this knowledge gap.  In a first project\, we use human mammary organoids to make the remarkable observation that tissues can behave as dynamic structural ensembles. We model the ensemble using a maximum entropy framework\, and demonstrate the probability distribution of tissue structures is a function of the entropy associated with cell arrangements\, the energy associated with cell interfaces\, and mechanical fluctuations associated with cell motility.  We map these parameters back to measurable molecular and mechanical properties of cells and their microenvironment\, allowing us to engineer the structural ensemble quantitatively and systematically.  In a second project we use the morphogenesis of mouse intestinal villi to reveal that tuning the geometry and active mechanics of the epithelial/mesenchymal interface is sufficient to sculpt a diversity of tissue forms. In the gut\, MMP and Myosin-II dependent fluidization of a contractile and adhesive sub-epithelial mesenchyme results in a dynamic monolayer of cells with a high surface tension. Minimization of surface energy results in a process we call “mesenchymal de-wetting\,”  which results in the formation of an array of multicellular condensates that act to pattern and fold the overlying epithelium. Manipulating the properties of the cells or the interface results in predictable changes to the pattern and shape of the folds. These studies have some important implications for tissue engineering\, disease progression\, and our understanding of tissue self-organization in other contexts.
URL:https://ibecbarcelona.eu/event/ibec-seminar-zev-gartner/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230712T160000
DTEND;TZID=Europe/Madrid:20230712T170000
DTSTAMP:20260408T042942
CREATED:20230706T124124Z
LAST-MODIFIED:20230706T124124Z
UID:109536-1689177600-1689181200@ibecbarcelona.eu
SUMMARY:IBEC-IFIBYNE Webinar Cycle (online) 12th July 2023 at 16:00 Javier Ramon
DESCRIPTION:Organ on a chip models to emulate multi systemic metabolic diseases\nJavier Ramon\, IBEC \nExisting on-chip tissue models typically represent a single organ\, limiting systemic drug investigations. Microscale tissue analog systems aim to improve drug and toxicity predictions across various organs. However\, multi-organ devices are limited\, and none have explored skeletal muscle and pancreatic islets. We developed a novel multi-organ-on-a-chip platform for real-time\, sensitive monitoring of cross-talk between two organs. Unlike previous electrochemical platforms\, our sensing system offers cost-effectiveness\, label-free detection\, easy integration\, multiplexing\, and real-time monitoring. This platform quantifies secreted proteins with high sensitivity\, crucial for understanding the relationship between skeletal muscle and the pancreas. Our work shows promise for disease modeling\, drug screening\, and personalized medicine. \n\nDoctor Javier Ramon is an ICREA Professor since 2021 and the leader of the Biosensors for Bioengineering group at the Institute of Bioengineering of Catalonia. Javier studied Chemistry at the University of Catalonia and completed his PhD at the CSIC in the Institute of Advanced Chemistry of Catalonia. He conducted his postdoctoral research in Japan at the Advanced Institute of Materials and returned to Spain in 2016 as a Ramon y Cajal researcher. His research is focused on tissue engineering\, biomaterials\, biosensors\, and integrating these technologies into organ-on-chip devices to study diseases and drug screening.
URL:https://ibecbarcelona.eu/event/ibec-ifibyne-webinar-cycle-online-12th-july-2023-at-1600-javier-ramon/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230714T100000
DTEND;TZID=Europe/Madrid:20230714T150000
DTSTAMP:20260408T042942
CREATED:20230705T105639Z
LAST-MODIFIED:20230705T105639Z
UID:109521-1689328800-1689346800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Manuel López Ortiz
DESCRIPTION:Single molecule electrochemical studies of photosynthetic complexes\n\n\n\n\nAuthor: Manuel López Ortiz\, Nanoprobes and Nanoswitches group\n\n\nReading date: 14/07/2023\nReading time: 10:00 \nReading place: Aula de graus Dufort de la facultat de biologia
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-manuel-lopez-ortiz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230714T120000
DTEND;TZID=Europe/Madrid:20230714T140000
DTSTAMP:20260408T042942
CREATED:20230712T061637Z
LAST-MODIFIED:20230712T061637Z
UID:109735-1689336000-1689343200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Gerardo Ceada
DESCRIPTION:Mechanics of crypt folding\, tissue compartmentalization and collective cell migration in intestinal organoids\n\n\n\n\nAuthor: Gerardo Ceada\, Integrative cell and Tissue Dynamics group\n\n\nReading date: 14/07/2023\nReading time: 12:00 \n\n\nReading place: Aula Magna de la Facultad de Medicina de la Universidad de Barcelona (Campus Clínic) \n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-gerardo-ceada/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230718T100000
DTEND;TZID=Europe/Madrid:20230718T113000
DTSTAMP:20260408T042942
CREATED:20230712T092151Z
LAST-MODIFIED:20230712T092151Z
UID:109754-1689674400-1689679800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dan Vigneron
DESCRIPTION:Translation and Initial Patient and Volunteer Studies with Hyperpolarized Carbon-13 MR Molecular Imaging\nDan Vigneron\, Department of Radiology & Biomedical Imaging\, University of California San Francisco \n“Hyperpolarized (HP) carbon-13 MRI is an emerging molecular imaging method to monitor enzymatic conversions through key\, previously-inaccessible biochemical pathways. Over 1000 human HP carbon-13 MR studies to date have shown outstanding research and potential clinical value. Just as MRI has shown value for medical imaging providing information beyond CT/X-ray\, HP C-13 MRI can provide new isotope imaging biomarker information in addition to what PET & SPECT do. HP C13 MRI is safe\, ~2min\, non-radioactive addition to standard-of-care MRI exams\, at costs less than separate PET exam. At the UCSF Hyperpolarized MRI Technology Resource Center\, we are developing new techniques for rapid dynamic acquisitions to measure HP conversion rates for [1-13C]pyruvate to [1-13C]lactate\, [1-13C]alanine and 13C-bicarbonate in the abdomen\, pelvis\, heart and brain to monitor cellular metabolism in normal tissues and pathologies. We are conducting over 15 clinical trials of HP C-13 MRI and have translated 4 different HP probes into first human studies: [1-13C]pyruvate\, [2-13C]pyruvate\, [1-13C]alpha-ketoglutarate\, and 13C-urea. Initial results demonstrate the ability to detect cancer aggressiveness\, response to therapy\, cardiac disease and brain bioenergetics. \n\nDr. Daniel B. Vigneron Ph.D. is a Professor in the Department of Radiology & Biomedical Imaging and at the University of California\, San Francisco. He also has joint appointments in the Departments of Bioengineering & Therapeutic Sciences and Neurological Surgery at UCSF and is a member of the UCB/UCSF Bioengineering graduate group. He directs the UCSF Human Imaging Core and the Advanced Imaging Technologies Resource Group that facilitates imaging technique development in the Department of Radiology & Biomedical Imaging including: Hyperpolarized Carbon-13\, PET-MR\, and 7T MR. He also is the Director of the NIH NIBIB-funded Hyperpolarized C-13 MRI Technology Resource Center at UCSF that was recently renewed till 2027 with 20 external collaborative and service projects. This UCSF Hyperpolarized MRI Technology Resource Center also sponsors numerous training and education opportunities including symposia/workshops focused on the development and dissemination of new HP-MRI techniques. Dr. Vigneron was elected Fellow of the International Society of Magnetic Resonance in Medicine in 2009 and to the College of Fellows of the American Institute for Medical and Biological Engineering in 2007. He received the Academy of Radiology Research Distinguished Investigator Award in 2013 and with colleagues was awarded the Gold Medal of the World Molecular Imaging Society in 2014. \nDr. Vigneron obtained his BA in Chemistry from Wesleyan University in Middletown\, Connecticut in 1983\, and he completed his PhD research in Pharmaceutical Chemistry from UCSF in 1988 and then conducted post-doctoral research at the Fox Chase Cancer Center in Philadelphia and at UCSF developing new MRI techniques for characterizing disease and therapy response. Prof. Vigneron’s research is focused on the development of metabolic MRI techniques for research and clinical assessments of human diseases. This research has been reported in over 350 total publications resulting in over 39\,000 citations with an h-index of 109 and an i10-index of 339 and has been funded by 25 NIH grant awards including as PI: 3 P41\, 1 P01 2 U01\, 18 R01 and 1 S10 grant awards. Also\, he has served as the Primary Mentor on 6 NIH career mentored awards. Dr. Vigneron leads the technical development aspects of the hyperpolarized carbon-13 MR program at UCSF and is the Principal Investigator of seven current NIH funded projects focused on new HP metabolic MRI techniques applied to clinical research studies of prostate cancer\, metastatic cancers\, brain disorders and CNS tumors.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dan-vigneron/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230718T150000
DTEND;TZID=Europe/Madrid:20230718T170000
DTSTAMP:20260408T042942
CREATED:20230711T111654Z
LAST-MODIFIED:20230711T111654Z
UID:109689-1689692400-1689699600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Sefora Conti
DESCRIPTION:Mechanical phenotyping of cancer stemness in colorectal cancer.\n\n\n\n\nAuthor: Sefora Conti\, Integrative cell and Tissue Dynamics group\n\n\nReading date: 18/07/2023\nReading time: 15:00 \n\nAbstract: Colorectal cancer tumors are composed of heterogeneous and plastic cell populations\, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties\, and how these properties might contribute to metastasis is unknown. Using CRC patient derived organoids (PDOs)\, we found that compared to LGR5- cells\, LGR5+ cancer stem cells are stiffer\, adhere better to the extracellular matrix (ECM)\, move slower both as single cells and clusters\, display higher nuclear YAP\, show a higher survival rate in response to mechanical confinement\, and form larger transendothelial gaps. These differences are largely explained by the downregulation of the membrane to cortex attachment proteins Ezrin/Radixin/Moesin (ERMs) in the LGR5+ cells. By analyzing scRNA-seq expression patterns from a patient cohort\, we show that this downregulation is a robust signature of colorectal tumors. Our results show that LGR5- cells display a mechanically dynamic phenotype suitable for dissemination from the primary tumor whereas LGR5+ cells display a mechanically stable and resilient phenotype suitable for extravasation and metastatic growth. \n  \n\nReading place: Aula Marga\, Hospital Clinic \n\nMore information here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-sefora-conti/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230726T120000
DTEND;TZID=Europe/Madrid:20230726T130000
DTSTAMP:20260408T042942
CREATED:20230724T071319Z
LAST-MODIFIED:20230724T071618Z
UID:110268-1690372800-1690376400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: MDr Joanna Sierpowska
DESCRIPTION:Awake brain surgery mapping – a way to mitigate postsurgical impairments and a door to understanding human cognition\nMDr Joanna Sierpowska from the Department of Cognition\, Development and Educational Psychology\, Institute of Neurosciences\, University of Barcelona \nBrain mapping for language and cognition during awake brain surgeries helps neurosurgeons to mitigate postsurgical impairments. At the same time\, it uncovers the truth about brain functional organization. While the cortical procedures are very well studied and widely implemented since the ’50 of the XX century confirming the classical models of language production\, the work on mapping the white matter pathways has developed very recently. The dual pathway model for language introduces the importance of the perisylvian white matter in the processing of speech sounds and word meaning. In the present talk\, I will explain if the model was successfully confirmed by intraoperative language testing. Furthermore\, I will explain how we assess language function associated with the model perioperatively in a large sample of brain tumor patients. 
URL:https://ibecbarcelona.eu/event/ibec-seminar-mdr-joanna-sierpowska/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230726T150000
DTEND;TZID=Europe/Madrid:20230726T170000
DTSTAMP:20260408T042942
CREATED:20230712T082101Z
LAST-MODIFIED:20230712T082101Z
UID:109742-1690383600-1690390800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Matthias Schulze
DESCRIPTION:Highlights of 20 years DNP with Merck as partner\nMatthias Schulze\, Merck \nIntroduction of Merck’s capabilities to supply specifically labeled tracers in different grades.\nDescribing the milestones of DNP towards establishing that method as a powerful tool in cancer diagnostics. Outlining the challenges and the scope on projects utilizing 13 C labeled reagents. \n\nMatthias Schulze studied chemistry at the TU Berlin and gained his PhD in 1991 for research in natural product synthesis. Subsequent stays at various sites abroad (Norman\, Oklahoma and Columbus\, Ohio) extended his expertise in analytical and synthetical techniques. Later\, he worked as a group leader at the University Bonn on mechanistic questions in metal-organic chemistry and new ways to access cyclic natural products. He has 20 years of experience in stable isotopes and its applications in a corporate environment. His current role is that of a technology manager for stable isotopes in EMEA. Ever since he worked with numerous researchers to support them in a broad range of fields\, focusing on biochemical and medicinal topics \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-matthias-schulze/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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