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DTSTART;TZID=Europe/Madrid:20230905T100000
DTEND;TZID=Europe/Madrid:20230905T120000
DTSTAMP:20260408T013238
CREATED:20230724T080449Z
LAST-MODIFIED:20230724T080449Z
UID:110271-1693908000-1693915200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Virgil Percec
DESCRIPTION:Reprogramming the Factory of Life to Target the Delivery of mRNA via Helical Chirality\nVirgil Percec\, Roy & Diana Vagelos Laboratories\, Department of Chemistry\, University of Pennsylvania\, Philadelphia \nHomochiral helical self-organizations are known at the macroscopic level in nature\, art\, architecture and science for thousands of years [1a\,b]. However\, molecular helicity was discovered in proteins and DNA [2] only in the early 1950th and in molecular\, macromolecular and supramolecular complex nanosystems emerged soon after [1c\,d\,e\,f]. Our ability to program functions at the supramolecular level based on helical chirality is less advanced than the same process at the macroscopic level during Archimedes and Leonardo da Vinci times. The principles “discover-elucidate mechanism-predict programmed primary structure” elaborated in our laboratory and aided by synthetic methodologies developed also in our laboratory for accelerated modular-orthogonal synthesis of programmed structures such us Ni-catalyzed cross-coupling\, mixed-ligand\, thio-bromo click\, SET-organic and polymerizarion reactions\, self-accelerated and self-interrupted synthesis including selected examples of homochiral helical self-organizations and functions together with the molecular factory of life will be briefly explained. The origins of helical homochirality is equivalent to the origins of life although the origins and the rational of biological membranes homochirality continues to be debated [3]. Inspiration from amphiphilic Janus dendrimers [4a] and Janus glycodendrimers [4b] discovered in our laboratory allowed to transit from the commercial viral and four-component lipid nanoparticle synthetic vectors for delivery of mRNA to the one-component ionizable multifunctional sequence-defined amphiphilic Janus dendrimers (IAJDs) delivery vector [5]. The current status of the molecular design principles providing the least expensive and the simplest access to targeted delivery of mRNA with programmed IAJDs will be discussed in great details. Targeted delivery of mRNA to all organs is expected to change the field of nanomedicine at the most fundamental level by providing unprecedented avenues to new vaccines and therapeutics. \nReferences \n\n(a) Percec\, V.; Xiao\, Q. Bull. Chem. Soc. Jpn. 2021\, 94\, 900-928. (b) Percec\, V.; Adamson\, J.; Gianti\, E. Supramolecular Nanotechnology\, Wiley-VCH\, 2023\, Azzaroni\, O.; Conda-Sheridan\, M. Eds. Vol.1\, p. 1-123. (c) Percec\, V. Lab. Science 1997\, 278\, 449-452. (d) Nature 1998\, 391\,161-164. (e) Nature 2002\, 419\, 384-387. (f) Nature 2004\, 430\, 764-768.\n(a) Pauling\, L.; Corey\, J. Am. Chem. Soc. 1950\, 72\, 5349-5349; (b) Watson\, J. D.; Crick\, F.H.C. Nature 1953\, 171\, 737-738; (c) Percec\, V.; Xiao\, Q. CHEM 2021\, 7\, 529-536; (d) Percec\, V. CHEM 2023\, August issue.\nPercec\, V. Lab. J. Am. Chem. Soc. 2023\, 145\, 4311-4323.\n(a) Percec\, V. Lab. Science\, 2010\, 328\, 1009-1014; (b) Percec\, V. Lab. J. Am. Chem. Soc. 2013\, 135\, 9055-9077.\n(a) Percec\, V. and Weissman D. Labs. J. Am. Chem. Soc. 2021\, 143\, 12315-12325; (b) J. Am. Chem. Soc. 2021\, 143\, 18803-12325; (c) J. Am. Chem. Soc. 2022\, 144\, 4746-4753; (d) Pharmaceutics 2023\, 15\, 1572; (e) J. Am. Chem. Soc. Submitted.\n\n\nVirgil Percec was born and educated in Romania (BS in Organic and Macromolecular Chemistry at the Polytechnic University in Iasi\, PhD in 1976 with C. I. Simionescu. In 1981 he defected his native country and after short postdoctoral stays at the University of Freiburg in Germany (July 1981 with H. -J. Cantow) and University of Akron\, US (August 1981 to March 1982 with J. P. Kennedy) he joined the Department of Macromolecular Science of Case Western Reserve University in Cleveland\, US in March 1982 as an Assistant Professor. He was promoted to Associate Professor in 1984 and to Professor in 1986. In 1993 he was awarded the Leonard Case Jr. Chair at Case Western Reserve University and in 1999 he was invited and moved to the University of Pennsylvania in Philadelphia as P. Roy Vagelos Chair and Professor of Chemistry. He has been repeatedly a Visiting Professor at the Universities of Freiburg\, Ulm and at the Max Planck Institute for Polymer Research in Mainz (all in Germany) and at the Royal Institute of Technology in Stockholm. His research interest is at the interface between organic\, supramolecular\, macromolecular chemistries\, liquid crystals\, nanoscience and biology where he contributed over 820 refereed publications\, 80 patents\, edited 20 books and presented over 1300 endowed\, invited and plenary lectures. He educated over 3509 students and postdocs over 70 of them being in university professors all over the world.
URL:https://ibecbarcelona.eu/event/ibec-seminar-virgil-percec/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20230915T100000
DTEND;TZID=Europe/Madrid:20230915T113000
DTSTAMP:20260408T013238
CREATED:20230710T085202Z
LAST-MODIFIED:20230710T085202Z
UID:109584-1694772000-1694777400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Andy Tay
DESCRIPTION:Biomaterials for cancer study and accelerate wound healing\nDr. Andy Tay \, Assistant Professor\, Presidential Young Professor\, Department of Biomedical Engineering \nMagnetic hydrogels are materials containing magnetic microparticles which help transduce magnetic fields into mechanical forces. In the presence of a static magnet\, the stiffness of magnetic hydrogels can be altered to investigate the reversible effects of matrix softening and stiffening on cellular behaviours. Here\, I will describe how we exploit this unique feature of our material for cancer study. \nThe World Health Organization estimates that 10% of the world’s population suffers from diabetes\, and diabetic patients has a 15-25% lifetime risk of getting diabetic foot ulcers. Every 20s\, there is a lower extremity amputation worldwide. In the second half of my talk\, I will describe the use of magnetic hydrogel for mechanical stimulation of cells to synergistically accelerate diabetic wound healing. \n\nAndy Tay graduated in 2014 from NUS with a First-Class Honours in Biomedical Engineering. He later headed to the University of California\, Los Angeles for his PhD studies and graduated in 2017 as the recipient of the Harry M Showman Commencement Award. Andy next received his postdoctoral training at Stanford University before heading to Imperial College London as an 1851 Royal Commission Brunel Research Fellow. He is currently a Presidential Young Professor in NUS. \nAndy is a recipient of international awards including the Interstellar Initiative Early-Career Faculty Award\, Christopher Hewitt Outstanding Young Investigator Award\, Terasaki Young Innovator Award. He is listed as a 2019 Forbes 30 Under 30 (US/Canada\, Science)\, 2020 World Economic Forum Young Scientist\, 2020 The Straits Times ‘30 and Under’ Young Singaporeans to Watch and 2022 Top 2% Scientist in the World by Stanford University. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-andy-tay/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20230921T080000
DTEND;TZID=Europe/Madrid:20230921T170000
DTSTAMP:20260408T013238
CREATED:20230907T152119Z
LAST-MODIFIED:20230907T152119Z
UID:110774-1695283200-1695315600@ibecbarcelona.eu
SUMMARY:The Future Now: Emerging Leaders in Biomedicine
DESCRIPTION:We are delighted to announce the first edition of the symposium “The Future Now: Emerging Leaders in Biomedicine“. This event is specifically tailored for advanced postdoctoral researchers and junior Group Leaders who are at the forefront of the vibrant biomedical community of the Barcelona area. Join us at the Josep Carreras Leukaemia Research Institute (IJC) on September 21\, 2023. This Symposium is co-organized by the Josep Carreras Leukaemia Research Institute (IJC)\, the Vall d’Hebrón Institute of Oncology (VHIO)\, the Institute for Bioengineering of Catalonia (IBEC)\,the Institute of Molecular Biology of Barcelona (IBMB)\, the Centre for Genomic Regulation (CRG) and the University Pompeu Fabra\, Department of Medicine and Life Science. \n\nThis symposium will be a unique opportunity for emerging leaders in biomedicine of the region to network\, showcase their cutting-edge research\, and foster collaborations. By participating in this event\, early-career researchers will gain visibility\, build valuable connections\, and contribute to strengthening the local scientific ecosystem. \n\nThe program features a rich scientific agenda encompassing diverse disciplines within biomedicine\, with oral presentations from distinguished young researchers covering basic and translational research\, as well as cutting edge technologies. We will hold an engaging round table discussion focused on the relevant challenges faced by researchers at different stages of becoming independent investigators. Please find the program of the Symposium here. \nThe Emerging Leaders Symposium receives the support of Miltenyi Biotec\, Macrogen\, BGI Genomics\, Bonsai Lab & Labclinics. \n\nREGISTRATION:\n\nWe extend a warm invitation to all postdoctoral researchers and junior Group Leaders in the Barcelona area to join us at the “Emerging Leaders in Biomedicine” symposium. \n\n\nAll participants of the event need to register via the following link: https://forms.office.com/e/LfGzP4tMJT\nRegistration is free.\nDeadline for registration is September 8\, 2023.\n\n\nBy coming together\, we can shape the future of biomedicine\, establish enduring connections\, and contribute to the advancement of science in our local community and beyond. \n\nEMERGING LEADERS BOOK\n\nAttendees will have the opportunity to present their research interests through virtual short presentations in the “Emerging Leaders Book”\, fostering in-depth discussions and providing constructive feedback during the networking session and beyond. It’s an excellent opportunity for participants to refine their research ideas and expand their scientific horizons. \n\nAll participants wishing to appear in the “Emerging Leaders Book” must send their information via the following link before September 8\, 2023: https://forms.office.com/e/pWPrj1rhK6
URL:https://ibecbarcelona.eu/event/the-future-now-emerging-leaders-in-biomedicine/
LOCATION:Josep Carreras Leukaemia Research Institute
CATEGORIES:External symposium / conference / congress
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DTSTART;TZID=Europe/Madrid:20230927T120000
DTEND;TZID=Europe/Madrid:20230927T130000
DTSTAMP:20260408T013238
CREATED:20230803T110925Z
LAST-MODIFIED:20230803T110925Z
UID:110580-1695816000-1695819600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mariano Vázquez
DESCRIPTION:Supercomputer-based virtual humans: the future of medicine NOW\nMariano Vázquez\, ELEM Biotech & Barcelona Supercomputing Center \nIn this talk we are going to address the potential of supercomputer-based virtual humans for the biomedical realm. Virtual Humans are computational “avatars” of a patient\, which combines data with a mathematical model which are used to predict (as opposed to measure with experiments) some quantities of interest\, under a context of use and used to support medical decisions. We will show examples of Populations of Virtual Humans used as cohorts for in-silico clinical trials to optimize drug or devise-based therapies. \nOur examples are mostly of the cardiovascular and respiratory domains.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mariano-vazquez/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20230929T100000
DTEND;TZID=Europe/Madrid:20230929T113000
DTSTAMP:20260408T013238
CREATED:20230912T131744Z
LAST-MODIFIED:20230912T131744Z
UID:110815-1695981600-1695987000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: New technologies for accelerating drug discovery and preclinical testing
DESCRIPTION:New technologies for accelerating drug discovery and preclinical testing\nMaria Majellaro\, Chief Scientific Officer of Celtarys. \nAbi J Vazquez. Co-founder and COO of DIVERSA Technologies SL.\nBruno K Rodiño-Janeiro\, Chief Scientific Officer of BFlow. \n  \nCeltarys\, DIVERSA and BFlow belong to the Galician biotechnology ecosystem and are dedicated to provide cutting-edge technologies applied in different and complementary phases of preclinical drug screening\, accelerating the drug development process and reducing the time to market of new therapies. \nThe three companies emerge from technologies developed at public research centers and transferred to the market after participation in validation programs. The speakers will explain their experiences in the process of going from an idea in the laboratory to the final technology transfer as spin-off companies. \nCeltarys is a spin-off of the University of Santiago de Compostela\, focused on the development of innovative fluorescent tools to improve the efficiency of the drug discovery process. In addition to its fluorescent ligand portfolio\, Celtarys specializes in customized fluorescent ligands for target-based drug discovery\, utilizing its proprietary conjugation technology. This unique approach allows to quickly design and develop libraries of different tailor-made fluorescent ligands with their own linkers covering wide chemical architectures for any target of interest. \nDIVERSA is a spin-off from the Santiago de Compostela Health Research Institute (IDIS) and the Galician Health Service (SERGAS)\, devoted to drive the translation of new therapeutic molecules to the clinic through the application of patented safe-by-design lipid nanoemulsions that can efficiently improve the delivery of drugs and biomolecules (RNAs\, proteins and peptides ) to their target\, and thus efficacy. DIVERSA commercialize ready-to-use reagents\, and also provides customized services for the development of tailored and unique formulations that can accomplish all requirements for a specific molecule\, indication\, and route of administration. We also conduct comprehensive R&D activities to advance our own nanomedicines towards the clinic\, answering to current unmet clinical needs. \n  \nBFlow is a spin-off from the University of Santiago de Compostela (USC) and the Health Research Institute of Santiago de Compostela (IDIS)\, which offers advanced Organ-on-a-chip models to improve the physiological relevance of cell cultures. BFlow products are designed to cover the urgent need to improve the data in both research laboratories and the pharmaceutical industry. Regarding the latter\, Organ-on-a-chip models will have a relevant role reducing the cost\, time and use of experimental animal models in the preclinical drug screening process\, accelerating the discovery of new drugs. \n  \nThe seminar will consist of 15 minute talks from each company with 15 minutes of questions and answers.
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-technologies-for-accelerating-drug-discovery-and-preclinical-testing/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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