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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20231002T120000
DTEND;TZID=Europe/Madrid:20231002T130000
DTSTAMP:20260408T000341
CREATED:20230912T132001Z
LAST-MODIFIED:20230912T132001Z
UID:110817-1696248000-1696251600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Simone Reber
DESCRIPTION:Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes\nSimone Reber\, Max Planck Institut for Infection Biology\, Berlin (invited by Pere Roca-Cusachs) \nThe packing and confinement of macromolecules in the cytoplasm and nucleoplasm has profound implications for cellular biochemistry. How intracellular density distributions vary and affect cellular physiology remains largely unknown. We show that the nucleus is less dense than the cytoplasm and that living systems establish and maintain a constant density ratio between these compartments. Using label-free biophotonics and theory\, we show that nuclear density is set by a pressure balance across the nuclear envelope in vitro\, in vivo and during early development. Nuclear transport establishes a specific nuclear proteome that exerts a colloid osmotic pressure\, which\, assisted by entropic chromatin pressure\, draws water into the nucleus. Using C. elegans\, we show that while nuclear-to-cytoplasmic (N/C) volume ratios change during early development\, the N/C density ratio is robustly maintained. We propose that the maintenance of a constant N/C density ratio is the biophysical driver of one of the oldest tenets of cell biology: the N/C volume ratio. In summary\, this study reveals a previously unidentified homeostatic coupling of macromolecular densities that drives cellular organization.
URL:https://ibecbarcelona.eu/event/ibec-seminar-simone-reber/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231003T090000
DTEND;TZID=Europe/Madrid:20231003T183000
DTSTAMP:20260408T000341
CREATED:20230619T141528Z
LAST-MODIFIED:20230619T141550Z
UID:108734-1696323600-1696357800@ibecbarcelona.eu
SUMMARY:16th IBEC SYMPOSIUM
DESCRIPTION:BIOENGINEERING FOR FUTURE AND PRECISION MEDICINE\n\n\n\n\nOctober 3rd · Auditori Axa\, Barcelona\nThe 16th IBEC annual Symposium brings together high-profile international experts for an open forum for interdisciplinary discussions and networking. This year the symposium is dedicated to Bioengineering for Future and Precision Medicine\, one of IBEC’s three major application areas. \nScientific community is invited to participate. Attendees from IBEC and abroad are welcome to present their research or projects in poster format. Moreover\, some of these contributions will be selected by the scientific committee for an oral flash presentation. \nRegistration here.
URL:https://ibecbarcelona.eu/event/16th-ibec-symposium/
LOCATION:AXA Auditorium\, L'illa Diagonal\, Av. Diagonal 547 \, Barcelona\, 08029
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231010T143000
DTEND;TZID=Europe/Madrid:20231010T163000
DTSTAMP:20260408T000341
CREATED:20231004T123727Z
LAST-MODIFIED:20231004T124040Z
UID:111456-1696948200-1696955400@ibecbarcelona.eu
SUMMARY:Workshop “Bioaction: The new tissue engineering approaches in bone infections"
DESCRIPTION:Workshop held in the framework of the EIC Pathfinder project BIOACTION “Bacteria biofilm as bio-factory for tissue regeneration” (Project Number 101098972). \nBIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections\, the primary cause of implant infections and failure\, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration\, exploiting gene sequences loaded on engineered liposomes and phages\, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone. \nBIOACTION\, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care\, health outcomes and to achieve huge socio-economic benefits. The project is strongly interdisciplinary in nature involving expertise biomaterials\, synthetic biology\, phage and liposome technology\, medicine. \nAs a results\, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead\, through the planned validation\, as proof-of-concept of new materials and technique with a broader application in regenerative medicine. \nIn this workshop\, participants from all the institutions involved in the project will explain their research and activities. \n  \nChairs: Elisabeth Engel\, Luigi Ambrosio \n14:30 – Claudia Siverini and Marco Chittò (AO Foundation)\, “Bone infections and treatments” \n14:45 – Dorien Van Hede (Université de Liege)\, “Dental infections and treatments” \n15:00 – Diego Cotella (Università degli Studi del Piemonte Orientale)\, “Phages to control biofilms” \n15:15 – Dr. Cecilia Bombelli (Consiglio Nazionale delle Ricerche – Instituto per i Sistemi biologici)\, “Liposomes in gene therapy” \n15:30 – Ramūnas Valiokas (Ferentis)\, “Crosslinked peptide hydrogels for tissue engineering and modeling” \n15:45 – Giovanna Gomez d’Ayala (Consiglio Nazionale delle Ricerche – Instituto per i Polimeri\, Compositi e Biomateriali)\, “Hydrogels for tissue regeneration” \n16:00 – Oscar Castaño (IBEC)\, “Advanced characterization methodology” \n16:15 – Roberta Marzella (Consiglio Nazionale delle Ricerche – IPCB) and Michela Candotti (IN Society) – “Tips on Management and Dissemination of European Projects” \n16:30 Discussion and conclusions
URL:https://ibecbarcelona.eu/event/workshop-bioaction-the-new-tissue-engineering-approaches-in-bone-infections/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231011T110000
DTEND;TZID=Europe/Madrid:20231011T130000
DTSTAMP:20260408T000341
CREATED:20231004T102504Z
LAST-MODIFIED:20231004T102504Z
UID:111446-1697022000-1697029200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jaap den Toonder
DESCRIPTION:Microfluidic technology enabling biomedical applications\nJaap den Toonder\, Microsystems Research Section\, Department of Mechanical Engineering\, and Institute for Complex Molecular Systems\, Eindhoven University of Technology.  \nCurrently\, visiting professor at IBEC\, Barcelona \nMicrofluidics is the science and technology of manipulating and analyzing fluid flow at small scales\, typically from millimeters down to micrometers. At these scales\, fluid flow is almost always laminar which enables excellent control over the flow. Microfluidic devices can be made using a range of microfabrication approaches and materials\, and these enable to integrate tailored electronic or mechanical functions. These unique properties of microfluidic technologies\, and the ongoing further development of the technology\, enable a range of new biomedical applications\, including diagnostic and monitoring devices\, medical implants\, and organ-on-chip. \nIn this lecture\, I will present recent developments within three research lines of our lab. (1) Bio-inspired microfluidics: A novel microfluidic flow generation concept inspired by nature\, which is based on magnetic nano- and micro-actuators we call “artificial cilia”; integrated in microfluidic devices\, these can be used to induce flow\, to manipulate particles\, and as actuators in cellular mechano-transduction research. (2) Microfluidic devices for health: Examples of microfluidic devices for health applications\, specifically a sweat sensing device for non-invasive semi-continuous monitoring of hospitalized patients\, and a smart eye implant to control eye pressure in glaucoma patients after surgery. (3) Organ-on-chip: A game-changing technology in which human cells are cultured in microfluidic chips simulating and predicting the response of healthy and diseased human tissues. I will focus on cancer-on-chip approaches to understand initial stages of cancer metastasis\, and on our lumen-based organ-on-chip models that are enabled by a 3D sugar printing technique we developed.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jaap-den-toonder/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231020T100000
DTEND;TZID=Europe/Madrid:20231020T113000
DTSTAMP:20260408T000341
CREATED:20231005T130733Z
LAST-MODIFIED:20231010T145141Z
UID:111469-1697796000-1697801400@ibecbarcelona.eu
SUMMARY:PhD Discussions: Thomas Wilson and Judith Fuentes
DESCRIPTION:Multiscale buckling of epithelial shells\nThomas Wilson\, Integrative Cell and Tissue Dynamics group \nNumerous natural and engineered structures are shaped as thin curved shells. When subjected to excessive compressive loading\, these shells undergo buckling instabilities that result in wrinkling patterns with complex dynamics. Epithelial tissues such as those enclosing embryos or lining glandular organs are a class of thin shells that displays three distinctive mechanical features: they are viscoelastic over the time scales of physiological loading\, they carry an active surface tension\, and their stress-bearing elements are distributed across scales. The conditions under which these material properties enable buckling\, and the subsequent structural changes are not understood. Here we establish the buckling dynamics of epithelial shells of controlled geometry over several orders of magnitude in time and space. We developed an experimental system that allows us to sculpt epithelial shells and subject them to controlled pressure differentials. We show that\, under rapid pressure reductions relative to a characteristic viscoelastic time of the system\, the tissue develops buckling patterns with different degrees of symmetry that depend on its size and shape. By contrast\, slow deflations allow the tissues to accommodate large strain variations without buckling. Strikingly\, we find that epithelial buckling is a multiscale phenomenon involving supracellular folds but also subcellular wrinkles in the actin cortex. Additionally\, we can harness the active viscoelastic behaviour of the cell cortex to pattern epithelial folds by rationally directed buckling. Our study shows that epithelial tissues can be understood as hierarchical materials with mechanical instabilities that can be harnessed to engineer morphogenetic events. \n\nEvaluation of self-healing properties in skeletal muscle-based bioactuators\nJudith Fuentes\, Smart Nano-Bio-Devices group \nThree dimensional bioprinting has opened new possibilities for the bioengineering of skeletal muscle models with organization and functionality similar to native tissues. This is key to understand the physiological conditions of skeletal muscle to integrate some of their unique properties\, such as self-healing\, adaptability\, and response to external stimuli\, in biohybrid systems. However\, the inherent self-healing capability of skeletal muscle has not been fully exploited in these advanced biohybrid platforms. In vivo\, skeletal muscle tissue may be repaired via the regenerative function of satellite cells (SC). However\, in in vitro conditions\, these cells are difficult to expand without altering their self-healing potential. Myogenic reserve cells (RC) offer an alternative potentially useful source to implement advanced regenerative capabilities in biohybrid systems. RC present similar properties to SC and arise during in vitro myoblast differentiation when a subpopulation escape from terminal differentiation. This work presents a 3D-bioprinted skeletal muscle bioactuator which self-healing properties have been evaluated after generating physical damage to the tissue\, either by creating cuts or crush injuries. Further studying over the underlying biological events related to muscle repair will be key to moving forward with the design of muscle-based bioactuators with on-demand assisted self-healing properties.
URL:https://ibecbarcelona.eu/event/phd-discussions-thomas-wilson-and-judith-fuentes/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231027T110000
DTEND;TZID=Europe/Madrid:20231027T170000
DTSTAMP:20260408T000341
CREATED:20231024T143039Z
LAST-MODIFIED:20231024T145618Z
UID:111800-1698404400-1698426000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Karen Wells Cembrano
DESCRIPTION:Development of 3D in vitro platforms for the study of muscle function and axonal growth and regeneration\n\n\n\n\nAuthor: Karen Wells Cembrano\, Molecular and cellular neurobiotechnology group\n\n\nReading date: 27/10/2023\nReading time: 11:00 \n\n\nReading place: Aula de Graus\, Biology Faculty\, UB \n\nTeams Link here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-karen-wells-cembrano/
CATEGORIES:PhD Thesis Defence
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