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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20240112T100000
DTEND;TZID=Europe/Madrid:20240112T110000
DTSTAMP:20260430T015613
CREATED:20231221T143650Z
LAST-MODIFIED:20240103T092736Z
UID:113540-1705053600-1705057200@ibecbarcelona.eu
SUMMARY:Transversal skills: Tess Marschner
DESCRIPTION:ANIMAL REMINDER\nPosthuman\, queer and animate perspectives on (Techno)Sciences \nI will introduce my previous artistic work and share the current state of my project at Ibec. It would be magnificent if my presentation leads to further thoughts and collaborations that are of interest to my project. \nI will focus on my installation work ANIMAL REMINDER in terms of intertwining artistic and scientific knowledge production. The philosopher Martha C. Nussbaum describes animal reminders as parts or aspects of the human body that evoke a strong aversion or even disgust: Blood\, saliva\, urine\, sweat\, amniotic fluid\, pus\, breast milk\, faeces\, ejaculate. Body surfaces of living beings are perforated several times\, ANIMAL REMINDER emerge from pores and body orifices\, interfaces of skins and mucous membranes at the boundary to air\, water and earth. ANIMAL REMINDER are reminiscent of the process of decomposition\, of slimy animals\, the uncontrollable loss of bodily fluids. They remind us that we ourselves are mortal and animal beings. \nIn case you are heavily interested in my work but unable to attend\, feel free to write me a pm and we can figure out a personal meeting.
URL:https://ibecbarcelona.eu/event/transversal-skills-tess-marschner/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240115T100000
DTEND;TZID=Europe/Madrid:20240115T133000
DTSTAMP:20260430T015613
CREATED:20240108T153848Z
LAST-MODIFIED:20240108T155248Z
UID:113853-1705312800-1705325400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Alis Olea
DESCRIPTION:Dynamics of nanoparticles in 3D tumor models\n\n\n\n\nAuthor: Alis Olea\, Nanoscopy for nanomedicine group\n\n\nReading date: 15/01/2024\nReading time: 10:00 \n\n\nReading place: Sala Eduard Fontserè \nIf you want to join online\, you can connect via Teams here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-alis-olea/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240119T100000
DTEND;TZID=Europe/Madrid:20240119T110000
DTSTAMP:20260430T015613
CREATED:20240104T082933Z
LAST-MODIFIED:20240104T083058Z
UID:113766-1705658400-1705662000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Al Jord
DESCRIPTION:Mechanisms of Organelle Remodeling for Cellular Function\nAl Jord\, Group leader of Mechanisc of organelle remodeling group\, Centre for Genomic Regulation\, Barcelona \nTo function\, organisms rely on vital organs which\, in turn\, rely on specialized cells. At the subcellular scale\, cell specialization is notably driven by robust mechanisms of organelle remodeling. Thus\, discovering these mechanisms is key for the fundamental understanding of organisms in health and disease\, as well as for improved organ engineering. In this seminar\, I will discuss my research on organelle remodeling in somatic and female germ cells. I will first show how multiciliated cells – critical for nervous\, respiratory and reproductive organs – repurpose conserved mechanisms of cell division to remodel organelles for motile ciliogenesis. I will then talk about how oocytes deploy a biophysical mechanism\, based on cytoplasmic force tuning\, to mechanically remodel nuclear RNA-processing organelles for reproductive success. I will conclude with some future research plans\, blending my past and present interests into an interdisciplinary project that will venture into unexplored grounds of nuclear organelle mechano-regulation in somatic cells to deepen our understanding of organ development and homeostasis. \n\nKey relevant publications : \n  \nAl Jord\, A. et al. Centriole amplification by mother and daughter centrioles differs in multiciliated cells. Nature 516\, 104–107 (2014). \n  \nAl Jord\, A. et al. Calibrated mitotic oscillator drives motile ciliogenesis. Science 358\, 803–806 (2017). \n  \nAl Jord\, A. et al. Cytoplasmic forces functionally reorganize nuclear condensates in oocytes. Nat. Commun. 13:5070\, 1–19 (2022).
URL:https://ibecbarcelona.eu/event/ibec-seminar-al-jord/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240126T100000
DTEND;TZID=Europe/Madrid:20240126T110000
DTSTAMP:20260430T015613
CREATED:20231128T135726Z
LAST-MODIFIED:20240119T112549Z
UID:112917-1706263200-1706266800@ibecbarcelona.eu
SUMMARY:PhD Discussions: Ainhoa Ferret and Marta Badia
DESCRIPTION:3D bioengineered liver for the study of acute and chronic hepatic damage\nAinhoa Ferret\, Biosensors for bioengineering group \nThe liver\, a vital organ\, faces acute and chronic insults that disrupt its normal function. Understanding the mechanisms underlying acute and chronic liver damage is crucial for developing effective treatments. Traditional liver models face several limitations. As a result\, 3D models have emerged as a more physiologically cellular microenvironment for investigating disease progression\, identifying potential therapeutic targets\, and developing new drugs. We developed a 3D liver using human hepatocytes\, HSCs\, and monocytes. The cells were encapsulated in a mixture of GelMA and CMCMA\, and LAP as a photo-initiator. The 3D livers were kept in culture for up to 30 days in serum-free medium. They were challenged with acetaminophen and LPS (APAP-LPS)\, known hepatotoxic compounds\, to recreate the pathophysiological phenotype of liver damage in vitro. Extensive liver damage characterized by hepatic stellate cell (HSC) activation and proliferation was observed upon challenge with APAP-LPS. In vivo\, these cells exhibited the myofibroblast phenotype typical of activated HSCs. Additionally\, impaired gene expression of hepatocyte functionality markers was observed. The transition from monocytes to proinflammatory cytokine-releasing macrophages measured the inflammation level. Notably\, dexamethasone demonstrated potent beneficial effects\, reducing hepatocyte damage\, inhibiting HSC activation\, and decreasing collagen production. These results were observed in both acute (high APAP-LPS concentration/3 days) and chronic (low APAP-LPS concentration/30 days) models. The 3D model presented here demonstrates its value as a versatile platform for drug screening in both acute and chronic liver damage scenarios. Its ability to reproduce critical features of liver pathophysiology\, including hepatocyte functionality impairment\, HSC activation\, and inflammation\, makes it a valuable tool for studying liver diseases and evaluating potential therapeutic interventions. Furthermore\, the adaptability of this model for high-throughput screening provides an opportunity to accelerate the drug discovery process and improve patient outcomes in liver damage-related conditions. \n  \nDisclosures \nConflict of interest: This study is supported by Grifols. \n  \n\nWhat makes a prion behave like a prion? Lessons from deep mutagenesis\nMarta Badia\, Protein phase transitions in health and disease group \nPrions are proteins capable of promoting conformational changes of other protein isoforms. When prion proteins switch from a soluble (non-prion) state to a misfolded (prion) state\, they can bind to each other forming small nuclei that can rapidly incorporate other monomers and form amyloid-like aggregates. Subtle differences in the sequence of prionic proteins are enough to impair the recruitment of monomers into these small nuclei\, creating a barrier for the nucleation of aggregates. Learning how this barrier is established (and overcome) is fundamental to explain prion nucleation and to understand cross-species prion infection. \nYeast prions serve as a good and tractable model to study amyloid formation and protein aggregation. Sup35 is one of the most intensively studied yeast prions and its N-terminal domain is sufficient for prion nucleation and the maintenance of its prionic state. However\, the mechanisms by which Sup35 starts nucleating amyloid aggregates and the features that prevent this nucleation still need to be elucidated. \nUsing deep mutagenesis\, we built a library encompassing all single amino acid changes in the QN-rich region (aa 2-40) of the Sup35 N-terminal domain. We then employed a massively parallel approach that combines high-throughput sequencing with a selection assay that is able to measure Sup35 nucleation in yeast cells. \nBy systematically quantifying the effect of hundreds of mutants in the QN-rich domain of Sup35 we determined the compatibility of each mutation with an effective Sup35 nucleation. Thanks to this dataset\, we identified a nine-residue segment (residues 17-25) crucial for this process. On the other hand\, our comprehensive dataset also uncovers mutants that increase Sup35 nucleation\, gaining mechanistic insights on the nucleation of this model system and how prion species barriers can be overcome.
URL:https://ibecbarcelona.eu/event/phd-discussions-ainoa-ferret-and-marta-badia/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240131T120000
DTEND;TZID=Europe/Madrid:20240131T130000
DTSTAMP:20260430T015613
CREATED:20231220T093851Z
LAST-MODIFIED:20240117T143436Z
UID:113528-1706702400-1706706000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Suarez Calvet
DESCRIPTION:Blood biomarkers for Alzheimer’s disease: advancing diagnosis and patient care\nMarc Suárez-Calvet\, Barcelonabeta Brain Research Center\, Fundació Pasqual Maragall\, Servei de Neurologia\, Hospital del Mar. \n  \nIn recent years\, one of the most significant breakthroughs in Alzheimer’s disease research has been the emergence of blood biomarkers that offer accurate detection of AD. Our research group has successfully demonstrated the utility of these blood biomarkers not only in patients presenting with cognitive impairement but also in individuals at the preclinical stage of Alzheimer’s. Moving forward\, our focus lies in establishing the routine application of these biomarkers in clinical settings\, with a keen eye on assessing their positive impact on patient outcomes. Furthermore\, our ongoing efforts are dedicated to the exploration of novel blood biomarkers that can furnish valuable insights into the prognosis of Alzheimer’s patients.
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-suarez-calvet/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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