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DTSTART;TZID=Europe/Madrid:20240913T140000
DTEND;TZID=Europe/Madrid:20240913T163000
DTSTAMP:20260425T102721
CREATED:20240909T074915Z
LAST-MODIFIED:20240909T074915Z
UID:120320-1726236000-1726245000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof Marcelle Machluf
DESCRIPTION:Harnessing the power of stem cell therapy in an off-the-shelf nano-delivery platform for treating brain disorders\nProf Marcelle Machluf\, Faculty of Biotechnology and Food Engineering\, Technion\, Haifa\, Israel \nMesenchymal stem cells (MSCs) have gained the most attention in cell therapy\, owing to their ability to traverse physiological barriers\, and target different sites of inflammation including neurological deseases and primary and metastatic tumors\, while exhibiting relative allogeneic safety. However\, once transplanted\, MSCs undergo changes that alter their targeting capabilities and increase their immunogenicity\, only permitting them to exert a short hit-and-run effect. We hypothesised that overcoming these challenges can be realised by combining the safety and inflamatory targeting capabilities of MSCs in an inanimate platform that can withstand limiting host influences. The foundations for this combination are laid by a novel class of nano-vesicles (200 nm)\, termed nano-ghosts (NGs)\, equipped with the membrane proteins of MSCs and can be engineered to express additional exogenous ones. The developed -cGMP compliant- technology for the production of NGs from the whole MSC membranes\, allow us to load them with a diverse payloads and/or engineer them to express ligands that can combat brain tumors and neuroinflamatory deseas such as MS.  Their abundance of natural targeting mechanisms allows the NGs\, injected i.v.\, to bypass the BBB and penetrate the entire tumor bulk or inflamatory site\, and rapidly deploy their payload directly into the targeted cells leading to unprecedented tumor growth inhibition and increased animals’ survival in intracranial glioma model. Surprising data also demonstrate that the NGs by themselves can modulate inflammation via cell-cell interaction and significaly reduce MS symtomes in EAE mice without any payload\, paving the way for their use in other neuroinflamatory deseas such as Alzhimer and Parkinson. Thus\, our results\, so far\, clearly demonstrate the translational potential of NGs\, both as targeted delivery platform as well as a novel immunomodulatory biologic  for brain diseass. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-marcelle-machluf/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240918T120000
DTEND;TZID=Europe/Madrid:20240918T130000
DTSTAMP:20260425T102721
CREATED:20240620T104256Z
LAST-MODIFIED:20240719T064603Z
UID:118726-1726660800-1726664400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria João Amorim
DESCRIPTION:Advances in understanding and manipulating influenza A virus liquid inclusions\nMaria João Amorim\, PhD\, Group Leader\, Cell Biology of Viral Infection Lab\, Católica Biomedical Research Centre\, Universidade Católica Portuguesa\, and Instituto Gulbenkian de Ciência\, Portugal \nMany viruses form biomolecular condensates de novo as part of their replication programmes. Influenza A virus is an important human pathogen that has the genome divided into eight different RNA segments. Interestingly\, each infectious particle contains no more than eight RNA segments and one of each type. Here\, we show that during infection influenza forms liquid condensates named viral inclusions where the eight RNA segments accumulate. Viral inclusions are formed with a single RNA type\, suggesting that these structures are formed before the genomic complex assembles and raises the hypothesis that these are specialized sites for the formation of influenza epidemic and pandemic genomic complexes. We will exchange views on why being liquid could constitute an interesting framework for understanding how influenza genomic complex forms. After\, we will expose advances on how viral inclusions are formed and provide proof of the concept that condensate hardening blocks viral infection in cellula and in vivo. Since native or engineered transitions affect condensate behavior\, phase transitions may offer novel antiviral opportunities for influenza\, as well as for many other viruses that utilize biomolecular condensates during their lifecycle. Finally\, we will show that our efforts to reconstitute in vitro influenza A virus inclusions give rise to a network of interactions built specifically during infection but\, despite being dynamic\, are not liquid but rather a gel-like state. We debate several hypothesis on why we have been unable for far to attain a liquid like character.
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-joao-amorim/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240925T180000
DTEND;TZID=Europe/Madrid:20240925T190000
DTSTAMP:20260425T102721
CREATED:20240910T111359Z
LAST-MODIFIED:20240910T111359Z
UID:120331-1727287200-1727290800@ibecbarcelona.eu
SUMMARY:Animal welfare VS human welfare: To what extent do we want to protect them? (Spanish)
DESCRIPTION:Animal welfare VS human welfare: To what extent do we want to protect them?\nThe use of experimental animals is widely accepted within the scientific community and although there are differences in regulations between countries\, they all follow the guidelines set by the 3Rs: Replace\, Reduce and Refine. This event will be held in Spanish. \n\nEl uso de animales de experimentación está ampliamente aceptado dentro de la comunidad científica y a pesar de que hay diferencias en regulaciones entre países todos siguen las directrices que marcan las 3.os: Reemplazar\, Reducir y Refinar. Por lo tanto\, la primera pregunta que nos tenemos que hacer cuando estamos diseñando un experimento con animales es: \nPodemos usar otro sistema que no involucre el uso de animales de experimentación para responder nuestra pregunta científica? \nAfortunadamente esta pregunta cada vez es más fácil de responder gracias al desarrollo de sistemas biomimètics que imitan ciertos órganos como por ejemplo la piel\, el intestino o el páncreas. \nProponemos la siguiente estructura para la mesa redonda: \nPresentación\nExploración de la situación con los asistentes a través de preguntas:\n• Qué impacto ha tenido durante la historia el uso de animales de experimentación?\n• Qué nos motiva a reducir el uso de los animales de experimentación?\n• Hasta qué punto estamos dispuestos a reducir su uso?\n• Qué alternativas tenemos?\nLluvia de ideas: Buscamos soluciones\nAntes que nada se explicarán las premisas por el buen funcionamiento de la lluvia de ideas. A continuación\, exploraremos las opciones que tenemos para reemplazar el uso de animales de experimentación.\nCon que nos quedamos?\nQué sueño las propuestas que entre todos los asistentes creemos que pueden tener más éxito?\nCierre\nPonentes: Marcel Sorribas Adriana González Anna Martínez y Daunis Xiomara Gislen Fernández Garibay Nuria Camarero (moderadora)\, del IBEC. \nPara registrarse haz click aquí.
URL:https://ibecbarcelona.eu/event/animal-welfare-vs-human-welfare-to-what-extent-do-we-want-to-protect-them-spanish/
LOCATION:Biblioteca Gabriel García Marquez
CATEGORIES:Outreach / Fair / Festival
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DTSTART;TZID=Europe/Madrid:20240926T090000
DTEND;TZID=Europe/Madrid:20240926T170000
DTSTAMP:20260425T102721
CREATED:20240719T062348Z
LAST-MODIFIED:20240925T155056Z
UID:119632-1727341200-1727370000@ibecbarcelona.eu
SUMMARY:Emerging Leaders in Biomedicine Symposium
DESCRIPTION:The second edition of the Emerging Leaders in Biomedicine Symposium will take place on September 26th\, 2024 at the Vall d’Hebron Institute of Oncology. This exceptional event is a collaborative effort between: \n\nVall d’Hebron Institute of Oncology (VHIO)\nJosep Carreras Leukaemia Research Institute\nInstitute for Bioengineering of Catalonia (IBEC)\nInstitute of Molecular Biology of Barcelona (IBMB)\nCentre for Genomic Regulation (CRG)\nUniversity Pompeu Fabra\, Department of Medicine and Life Science\nInstitute for Research in Biomedicine (IRB Barcelona)\nInstitute of Biomedicine of the University of Barcelona (IBUB)\n\nThe primary objective of this symposium is to provide a platform for senior postdocs and junior principal investigators (PIs) to come together and receive valuable scientific and logistical support from the local scientific community. \nDuring the symposium\, we will host several short talk sessions\, round tables\, and networking opportunities\, allowing you to showcase your research\, share the challenges you face\, present your scientific interests\, and explore potential synergies and collaborations. \nRegistration closed. \nFull programme here.   \n 
URL:https://ibecbarcelona.eu/event/emerging-leaders-in-biomedicine-symposium/
LOCATION:Vall d’Hebron\, Barcelona\, Spain
CATEGORIES:External symposium / conference / congress
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240926T100000
DTEND;TZID=Europe/Madrid:20240926T130000
DTSTAMP:20260425T102721
CREATED:20240904T154550Z
LAST-MODIFIED:20240916T103851Z
UID:120263-1727344800-1727355600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Marco Vigo
DESCRIPTION:Investigating therapeutic targeting to intercellular adhesion molecule 1 through epitope\, isoform\, and cross-reactivity selection\n\n\n\n\nAuthor: Marco Vigo\, Targeted Therapeutics and Nanodevices and Nanobioengineering group\n\n\nReading date: 26/09/2024\nReading time: 10:00 \n\n\nReading place: Facultat de Medicina de la Universitat de Barcelona – Aula 4.1 \nIf you want to join online\, you can connect via Teams here. \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-marco-vigo/
LOCATION:Facultat de Medicina de la Universitat de Barcelona – Aula 4.1
CATEGORIES:PhD Thesis Defence
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