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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20260408T150000
DTEND;TZID=Europe/Madrid:20260408T160000
DTSTAMP:20260513T224743
CREATED:20260331T123720Z
LAST-MODIFIED:20260331T123720Z
UID:133054-1775660400-1775664000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. M. Carolina Florian
DESCRIPTION:Targeting RhoA mechanoactivity rejuvenates aged hematopoietic stem cells  \nM. Carolina Florian\, Stem Cell Aging Group\, Regenerative Medicine Program\, The Bellvitge Institute for Biomedical Research (IDIBELL)\, L’Hospitalet de Llobregat\, Barcelona\, Spain. \nProgram for advancing the Clinical Translation of Regenerative Medicine of Catalonia\, P-CMR[C]\, Barcelona\, Spain\nThe Catalan Institution for Research and Advanced Studies (ICREA)\, Barcelona\, Spain\nMechanical alterations contribute to the decreased regenerative capacity of hematopoietic stem cells (HSCs) upon aging. RhoA is a key regulator of mechanosignaling\, but its role in mechanotransduction in stem cell aging remains unclear. Recently we have demonstrated that RhoA is activated by increasing nuclear envelope (NE) tension by cell confinement and by osmotic shock. Interestingly\, our data show that aged HSCs experience physiologically higher intrinsic NE tension and RhoA activation. We show that pharmacological inhibition of RhoA activity lowers NE tension in aged HSCs. Feature image analysis of HSC nuclei reveals that an aged dependent chromatin remodeling is responsible of higher NE tension levels upon aging. Moreover\, our data show that RhoA inhibition restores youthful levels of the heterochromatin marker H3K9me2 in aged HSCs and decreases chromatin accessibility and transcription at retrotransposons. Finally\, we demonstrated that RhoA inhibition in aged HSCs upregulates Klf4 expression and transcriptional activity\, improving aged HSC regenerative capacity and lympho-myeloid skewing in vivo. Together\, our data outline an intrinsic RhoA-dependent mechanosignaling axis in HSCs\, which can be pharmacologically targeted to restore aged stem cell function.
URL:https://ibecbarcelona.eu/event/ibec-seminar-m-carolina-florian/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260410T090000
DTEND;TZID=Europe/Madrid:20260410T160000
DTSTAMP:20260513T224743
CREATED:20260128T092058Z
LAST-MODIFIED:20260318T115649Z
UID:131745-1775811600-1775836800@ibecbarcelona.eu
SUMMARY:Thematic Network. NET-CNS Workshop 4: Innovations in CNS Modeling:Cutting-edge In Vitro Systems​
DESCRIPTION:Join us for the fourth NET-CNS Workshop on April 10th! \nThis fourth NET-CNS workshop will focus on innovative experimental platforms and technologies to model central nervous system (CNS) processes and diseases. Particular emphasis will be placed on advanced in vitro systems\, translational research tools\, and emerging technologies that enable more physiologically relevant models for studying CNS biology and developing therapeutic strategies. \nThe event will bring together experts from academia\, clinical research institutions\, and industry to discuss new approaches for understanding CNS function and pathology and for advancing biomedical innovation in neuroscience. \nSpeakers \n\nTeresa Botta Orfila – Head of the HCB-IDIBAPS Biobank (Barcelona). She leads initiatives in human biobanking\, biological sample management\, and translational infrastructures supporting biomedical research\, precision medicine\, and clinical studies.\nVíctor Borrell – Research Professor at the Instituto de Neurociencias (CSIC-UMH)\, Alicante. His research focuses on brain development and evolution\, particularly the cellular and molecular mechanisms that control neuronal migration\, cortical expansion\, and the formation of neural circuits.\nRosa Monge – Scientist at Beonchip (Zaragoza)\, a biotechnology company developing organ-on-chip technologies. Her work focuses on microphysiological systems and organ-on-chip platforms that enable the creation of advanced in vitro models for drug discovery and biomedical research.\nMaria Bernabeu – Group Leader at EMBL Barcelona. Her research integrates computational and experimental approaches to study tissue architecture and cellular organization\, using quantitative biology and advanced imaging to understand multicellular systems in health and disease.\nSandra Acosta – Professor at the University of Barcelona (UB) and researcher at Hospital Sant Joan de Déu and the Pasqual Maragall Foundation. Her research focuses on neurodegeneration and Alzheimer’s disease\, particularly on early pathological mechanisms\, neuroinflammation\, and translational strategies to identify biomarkers and therapeutic targets.\n\nProgramme \n09:30 – Registration \n09:50 – Welcome from Network Coordinator \n10:00 – IBEC Speaker: Jorge Oliver de la Cruz – Cellular and Molecular Mechanobiologygroup\, IBEC. “Mechanical cues regulate Tau axonal localization through microtubule stabilization” \n10:40 – Invited Speaker: Teresa Botta Orfila – Head of HCB-IDIBAPS Biobank\, Barcelona. “Biobanks as essential hubs for research”. \n11:20 – Coffee Break and Networking \n11:50 – Invited Speaker: Víctor Borrell – Instituto de Neurociencias (CSIC-UMH)\, Alicante. “Evolution of neural stem cells and lineages in the cerebral cortex of amniotes” \n12:30 – Industry Speaker: Rosa Monge – Beonchip\, Zaragoza. \n13:15 – Lunch Break \n14:15 – Invited Speaker: Maria Bernabeu – EMBL Barcelona. “Building and breaking barriers: bioengineered 3D brain microvascular models for malaria research” \n15:00 – Invited Speaker: Sandra Acosta – University of Barcelona\, Hospital Sant Joan de Déu & Pasqual Maragall Foundation\, Barcelona. “Modeling Neurological Disease Progression in vitro: The Promise and Pitfalls of Brain Organoids in Alzheimer’s and COVID-19” \n15:45 – End of the Workshop \nTo register click here.
URL:https://ibecbarcelona.eu/event/thematic-network-net-cns-workshop-4-innovations-in-cns-modelingcutting-edge-in-vitro-systems/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260415T120000
DTEND;TZID=Europe/Madrid:20260415T130000
DTSTAMP:20260513T224743
CREATED:20260320T075958Z
LAST-MODIFIED:20260320T080207Z
UID:132904-1776254400-1776258000@ibecbarcelona.eu
SUMMARY:Ibec Seminar: Dr. Federico Fenaroli
DESCRIPTION:Developing Nanomedicines Using the Zebrafish Embryo\nDr. Federico Fenaroli\,  University of Stavanger\, Norwey \nOur research focuses on the development of nanomedicines to combat bacterial infections and cancer. We investigate the dynamic in vivo interactions between nanoparticles\, immune cells\, and pathogenic bacteria or cancer cells. Thanks to their natural transparency\, zebrafish embryos enable high-resolution imaging and real-time tracking of nanoparticles within a living organism. This model provides valuable insights into therapeutic behavior\, biodistribution\, and host–pathogen interactions\, supporting the rational design of nanomedicines.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-federico-fenaroli/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260417T110000
DTEND;TZID=Europe/Madrid:20260417T110000
DTSTAMP:20260513T224743
CREATED:20250915T091947Z
LAST-MODIFIED:20250915T124500Z
UID:128356-1776423600-1776423600@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Prof. Kara Spiller
DESCRIPTION:Engineering Macrophages with Biomaterials for Regenerative Medicine\nKara L. Spiller\, PhD\, URBN Professor of Biomedical Innovation\, School of Biomedical Engineering\, Science\, and Health Systems\, Drexel University\, Philadelphia\, PA\, USA \nThe inflammatory response\, orchestrated primarily by macrophages\, plays a major role in the body’s response to injury\, disease\, or implantation of a biomaterial. When macrophages function normally\, they are a powerful force that promote tissue repair and regeneration\, but when their behavior goes awry\, healing is impaired. Our goal is to understand the mechanisms by which the inflammatory response orchestrates successful tissue regeneration and to develop novel biomaterial strategies that apply these principles to situations in which tissue regeneration is impaired. In particular\, we study macrophages in inflammation\, phagocytosis\, cellular recruitment\, vascularization\, cell proliferation\, tissue deposition\, or remodeling\, and we design biomaterials that leverage these findings for improved biomaterials design\, enhanced macrophage cell therapy\, and personalized medicine. Current projects in the lab are directed towards treatment of pulmonary fibrosis and chronic wound healing through biomaterial-enabled macrophage cell therapies. \nDr. Kara Spiller is the URBN Endowed Professor of Biomedical Innovation in Drexel University’s School of Biomedical Engineering\, Science\, and Health Systems. Her research focuses on the role of immune cells in tissue repair and regeneration and the design of immunomodulatory biomaterials. Her research is funded by the NIH\, the NSF\, private foundations\, and industry. Her awards include a Fulbright fellowship\, the NSF CAREER award\, and the United States Dept. of State ASPIRE prize. She has published more than 85 publications in biomaterials and immune engineering\, and has 18 issued or pending patents. She is the founding director of the Immune Modulation & Engineering Symposium series in Philadelphia\, which is the only annually recurring meeting dedicated to convergent research in translational immunology and engineering. She serves on the board of numerous journals and is a frequent NIH study section member.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-kara-spiller/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260420T160000
DTEND;TZID=Europe/Madrid:20260420T170000
DTSTAMP:20260513T224743
CREATED:20260417T070744Z
LAST-MODIFIED:20260417T070744Z
UID:133239-1776700800-1776704400@ibecbarcelona.eu
SUMMARY:Ibec Seminar: Hans Clevers
DESCRIPTION:Human organoids model disease in 3D and in 2D\nHans Clevers\, MD\, PhD \, Professor of Molecular Genetics\, Utrecht University  \nThe intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene\, transcribed in colon cancer cells. Two knock-in alleles revealed exclusive expression of Lgr5 in cycling\, columnar cells at the crypt base. Using lineage tracing experiments in adult mice\, we found that these Lgr5+ve crypt base columnar cells (CBC) generated all epithelial lineages throughout life\, implying that they represent the stem cell of the small intestine and colon. Lgr5 was subsequently found to represent an exquisitely specific\, yet ‘generic’ marker for active epithelial stem cells\, including in hair follicles\, kidney\, liver\, mammary gland\, inner ear tongue and stomach epithelium.  \nSingle sorted Lgr5+ve stem cells can initiate ever-expanding crypt-villus organoids\, or so called ‘mini-guts’ in 3D culture. The technology is based on the observation that Lgr5 is the receptor for a potent stem cell growth factor\, R-spondin. Similar 3D cultures systems have been developed for the Lgr5+ve stem cells of human stomach\, liver\, pancreas\, prostate and kidney. Using CRISPR/Cas9 technology\, genes can be efficiently modified in organoids of various origins. Organoid technology opens a range of avenues for the study of development\, physiology and disease\, for drug development and for personalized medicine. In the long run\, cultured mini-organs may replace transplant organs from donors and hold promise in gene therapy. \n\nAbout Hans Clevers: \nHans Clevers characterized the molecular effectors of the Wnt pathway: the TCF transcription factors. His group described the role of Wnt in (intestinal) stem cell biology and cancer\, eventually leading to the discovery of LGR5 as a novel stem cell marker. This eventually led him to pioneer tissue stem cell based organoids\, 3-dimensional in vitro structures that behave anatomically and molecularly like the organ from which they are derived. Organoid biology has revolutionized the way we approach human biology. \nHans Clevers obtained his MD and PhD degrees from the University of Utrecht\, the Netherlands. He holds a professorship in Molecular Genetics from the University of Utrecht. He previously held directorship/president positions at the Hubrecht Institute\, the Royal Netherlands Academy of Arts and Sciences and the Princess Maxima Center for pediatric oncology. He has served in the Supervisory Board (2019-2022) and as head of Roche’s Pharma Research & Early Development (pRED; 2022-2025). During this time\, he oversaw the establishment of Roche’s Institute of Human Biology (IHB) in Basel. He currently supervises his research groups at the Hubrecht Institute and the Princess Máxima Center. \nHe is the recipient of multiple international scientific awards\, including the Breakthrough Prize in Life Science. Hans Clevers is a member of the Royal Netherlands Academy of Arts and Sciences (NL)\, the National Academy of Sciences (USA)\, the Royal Society (UK) and the Academie des Sciences (France). He is also Chevalier de la Légion d’Honneur and Knight in the Order of the Netherlands Lion\, among many other international accolades.
URL:https://ibecbarcelona.eu/event/ibec-seminar-hans-clevers/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260424T093000
DTEND;TZID=Europe/Madrid:20260424T133000
DTSTAMP:20260513T224743
CREATED:20260410T062529Z
LAST-MODIFIED:20260410T062900Z
UID:133165-1777023000-1777037400@ibecbarcelona.eu
SUMMARY:Thematic Network. NET-AI Workshop 4: ML for data augmentation and compression and model explicability
DESCRIPTION:This 4th workshop of the NET-AI will cover key practical aspects of machine learning as it applies to the biomedical field\, such as data availability\, data management and interpretation of model outcomes. Through three talks by experts in the field\, novel methodologies for generating synthetic while realistic tabular data to complete incomplete datasets\, data augmentation strategies\, explainability techniques\, and image compression models will be presented.  \n  \nAGENDA  \n9:40 – 10:00 Welcome\n10:00 – 11:00 Cecilio Angulo\n11:00 – 11:30 Coffee break\n11:30 – 12:30 Kevin Barrera\n12:30 – 13:30 Alessia Amelio\n13:30 – 13:40 Closure  \nYou can register here. \n 
URL:https://ibecbarcelona.eu/event/thematic-network-net-ai-workshop-4-ml-for-data-augmentation-and-compression-and-model-explicabilit/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260430T104500
DTEND;TZID=Europe/Madrid:20260430T130000
DTSTAMP:20260513T224743
CREATED:20260320T095836Z
LAST-MODIFIED:20260320T095836Z
UID:132910-1777545900-1777554000@ibecbarcelona.eu
SUMMARY:Research4talent
DESCRIPTION:The event offers you the opportunity to engage with our researchers and inquire about their day-to-day work in the lab\, career trajectories\, work-life balance\, mobility\, etc. \nIn 2025\, IBEC signed more than 140 internship agreements for undergraduate and master’s students with a wide range of national and international universities. \n\n\nPROGRAMME · 30th April 2026 \n\n\n\n\n\n\n\n10:45\nWelcome\n\n\n11:00\nDeputy talent and training director talk. Elisabeth Engel\, “What is IBEC?”\n\n\n11:20\nPeople Management Speech\n\n\n11:30\nPhD Committee presentation\n\n\n\n-Coffee break-\n\n\n11:45\nCareers Fair*: a chance for participants to mingle and chat with our researchers.\n\n\n13:00\nLabs visits\n\n\n\n\n\nIf you are interested in IBEC’s twelfth edition of reSEARCH4TALENT\, please register.
URL:https://ibecbarcelona.eu/event/research4talent-8/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
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