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DTSTART;TZID=Europe/Madrid:20241115T100000
DTEND;TZID=Europe/Madrid:20241115T113000
DTSTAMP:20260418T161138
CREATED:20241002T150616Z
LAST-MODIFIED:20241002T150616Z
UID:120617-1731664800-1731670200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Slav Bagriantsev
DESCRIPTION:3D architecture and mechanism of touch detection in the Pacinian corpuscle \nSlav Bagriantsev\, Associate Professor of Cellular & Molecular Physiology\, Yale School of Medicine\, USA \nPacinian corpuscles are specialized mechanoreceptor end-organs that detect transient touch and high-frequency vibration in the skin and viscera of many vertebrates. Corpuscles have a complex cellular organization\, which includes a mechanoreceptor afferent surrounded by lamellar Schwann cells (LSCs) and several layers of outer core cells. How these components contribute to the sensory tuning of Pacinian corpuscles is unclear. We used Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) to determine the detailed 3D architecture of an entire Pacinian corpuscle\, including all corpuscular components\, and utilized electrophysiology to reveal the contribution of each component to touch detection. In the prevailing model\, the multilayered outer core serves as a mechanical filter that limits static and low-frequency stimuli from reaching the afferent terminal—the presumed sole site of touch detection in corpuscles. We show that the outer core is dispensable for the sensory tuning of Pacinian corpuscles to transient touch and high-frequency vibration; instead\, these properties arise from the inner core. We show that LSCs express mechanically gated ion channels and form a gap junction-coupled syncytium around the afferent terminal. By acting as additional touch sensors\, LSCs potentiate mechanosensitivity of the terminal\, which detects touch via fast inactivating ion channels. We present a new model\, in which the functional tuning of Pacinian corpuscles is enabled by an interplay between mechanosensitive LSCs and the afferent terminal in the inner core.
URL:https://ibecbarcelona.eu/es/event/ibec-seminar-slav-bagriantsev/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20241119T143000
DTEND;TZID=Europe/Madrid:20241119T163000
DTSTAMP:20260418T161138
CREATED:20241030T083108Z
LAST-MODIFIED:20241030T083216Z
UID:121140-1732026600-1732033800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Benoît Ladoux
DESCRIPTION:Mechanical imprints of cell fate and cell competition\nBenoît Ladoux\, Institut Jacques Monot (IJM) Paris \nEpithelia are communities of cells with close intercellular communications and of highly ordered coordination in their motion.\nMechanical properties of epithelial tissues are important for our understanding of many vital biological processes\, including homeostasis\, morphogenesis\, and metastasis and are tightly regulated by cell-cell interactions. I will present examples highlighting the importance of mechanical forces during cell extrusion and cell competition. In the first part\, I will focus on how cell extrusion and the fate of extruding cells from epithelial tissues can be determined by mechanical stresses. In the second part\, I will show how cell competition\, a mechanism by which the expansion of one cell population leads to the elimination of another\, can be governed by the transmission of intercellular forces. Throughout the talk\, I’ll discuss the close links between mechanics and cell biology\, as well as possible analogies between physical and biological systems.
URL:https://ibecbarcelona.eu/es/event/ibec-seminar-benoit-ladoux/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20241128T120000
DTEND;TZID=Europe/Madrid:20241128T133000
DTSTAMP:20260418T161138
CREATED:20241004T071403Z
LAST-MODIFIED:20241119T092340Z
UID:120615-1732795200-1732800600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Raül Andero Galí
DESCRIPTION:Translating fear mechanisms between humans and mice\nRaül Andero Galí\, PhD\, ICREA Research Professor at the Institute of Neurosciences of the Autonomous University of Barcelona \nSex-specific mechanisms in fear memory and extinction may explain certain neuropsychiatric disorders like Post-Traumatic Stress Disorder (PTSD). In male mice\, chemogenetic silencing of centromedial amygdala (CeM)-Tac2 fibers in the lateral posterior part of the Bed Nucleus of the Stria Terminalis (BNSTpl) impaired fear memory\, while optogenetic excitation enhanced inhibitory postsynaptic currents. In vivo calcium imaging in freely moving mice revealed a sex-dimorphic fear memory engram in the BNSTpl. In humans\, the TAC3R single nucleotide polymorphism (SNP) (rs2765) reduced CeM-BNST connectivity and impaired fear memory in men but not women. In a different study\, female mice subjected to acute stress exhibited fear extinction impairments linked to hypothalamic Pacap and Pac1R upregulation. Similar fear extinction deficits were observed in women with PTSD carriers of the PAC1R SNP (rs2267735). Together\, these studies highlight sex-differences in neural circuits regulating fear memory\, which may influence vulnerability to PTSD. \nPlease contact Silvia Pittolo if you would like to meet the speaker: spittolo@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/es/event/ibec-seminar-raul-andero-gali/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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