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DTSTART;TZID=Europe/Madrid:20220908T100000
DTEND;TZID=Europe/Madrid:20220908T130000
DTSTAMP:20260425T132552
CREATED:20220727T094315Z
LAST-MODIFIED:20220901T082933Z
UID:98652-1662631200-1662642000@ibecbarcelona.eu
SUMMARY:IBEC-IFIBYNE joint seminar
DESCRIPTION:10:00Institutional WelcomeJosep SamitierIBEC10:10Presentation by IFIBYNE directorAdali PecciIFIBYNE10:30Training-on-a-Chip: a multi-organ device to study the effect of muscle exercise on insulin secretion in vitroJavier RamónIBEC10:50Coffee Break11:20Genomic regulation in pancreatic beta cell development and regenerationSantiago RodríguezIFIBYNE11:40TBDRomén RodríguezIBEC12:00Closing\n\n\n\nThe seminar will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/es/event/ibec-ifibyne-joint-seminar/
LOCATION:Sala Baobab\, C/Baldiri Reixac 10-12\, Barcelona\, 08028\, Spain
CATEGORIES:Joint seminar / workshop / symposium
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DTSTART;TZID=Europe/Madrid:20220914T150000
DTEND;TZID=Europe/Madrid:20220914T170000
DTSTAMP:20260425T132552
CREATED:20220907T104718Z
LAST-MODIFIED:20220907T104718Z
UID:98989-1663167600-1663174800@ibecbarcelona.eu
SUMMARY:IBEC-IRB joint seminar
DESCRIPTION:Aberrant phase separation is a widespread killing mechanism of bioactive peptides in health and diseas\n\n\n\nSteven Boeynaems\, Assistant Professor at Baylor College of Medicine and Investigator at the Texas Children’s Hospital \n\n\n\nCationic repeat peptides are increasingly implicated in the pathophysiology of age-related neurodegenerative disease. These peptides are highly toxic in all tested disease models\, and seem to perturb an ever-expanding list of cellular pathways. This observation begs the question whether this target promiscuity is (1) relevant to disease and (2) how it is encoded in such simple sequences. A first clue came from the observation that these cationic repeat peptides have the tendency to drive protein condensation. Given their charge\, these peptides are exquisitely sensitive to the presence of nucleic acids. By studying their target space as a function of RNA concentration using mass spec\, we uncover a hidden hierarchy in their target preference that relates to subcellular differences in RNA abundance.  \n\n\n\nTo test whether these insights from disease translate to biology\, we used this framework to develop a machine learning algorithm that allowed us to predict protein behavior form sequence. Compellingly\, we uncover that bioactive peptides such as antimicrobial peptides produced by our own cells\, but also venom peptides derived from spiders\, scorpions and rattle snakes\, phenocopy the molecular behavior of these disease-related cationic peptides. In all\, we find that such peptides exert toxicity by upsetting the electrostatic balance of a cell\, hitting myriad pathways at once. We name this process polycation poisoning and find that it has independently evolved again and again across the entire tree of life as a killing strategy of bioactive peptides. Based on these findings we are now exploring toxin-antitoxin systems as innovative therapeutic strategies to protect neurons against cationic repeat peptide toxicity. \n\n\n\nHosts: Benedetta Bolognesi and Xavier Salvatella \n\n\n\nPlace: Felix Serratosa Hall\, PCB
URL:https://ibecbarcelona.eu/es/event/ibec-irb-joint-seminar/
LOCATION:Aula Félix Sarratosa\, PCB
CATEGORIES:Joint seminar / workshop / symposium
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