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DTSTART;TZID=Europe/Madrid:20240405T100000
DTEND;TZID=Europe/Madrid:20240405T110000
DTSTAMP:20260430T160231
CREATED:20240307T114216Z
LAST-MODIFIED:20240326T130314Z
UID:115873-1712311200-1712314800@ibecbarcelona.eu
SUMMARY:PhD discussions: Gülsun Bagci and Joana Admella
DESCRIPTION:Cell-Derived Extracellular Matrices for 3D in vitro Tumor Models\nGülsun Bagci\, Biomaterials for Regenerative Therapies Group \nDecellularized Extracellular matrices are new scaffolds for bioengineering of 3D tumor-ECM in vitro models. The tunable composition\, properties\, and structure of Cell-derived Matrices (CDMs) make them versatile and easy to use by using desired cell types. Moreover\, deposition of ECM can be achieved by adding specific stimulants such as Macromolecular crowding (MMC) like Ficoll/dextran sulfate or treating with hypoxia/starvation. Our aim is to fabricate CDM by two strategies as 2D culture CDMs from human dermal fibroblasts (hDFs)  or 3D culture CDM from bone marrow human mesenchymal stem cells (BM-hMSCs)/Human Adipose-derived stem cells (hAMSCs) in the presence of MMC/Ascorbic acid/ TGFβ-1  on Poly Lactic acid (PLA) derived microparticles (MPs) to generate 3D and 2D culture CDMs\, which can be used as scaffold for reseeding cancer cells or used as bioinks to generate tumor models for cancer research and for testing anti-cancer drugs. \nIn this study\, we generated 2D culture CDM from hDFs and 3D culture CDMs of BM-hMSCs and hAMSCs. To prepare 2D CDMs\, hDF were treated with Ascorbic acid (AA) or Ficoll\, AA\, TGFβ-1 combination for 2-weeks to increase the deposition of CDM. To fabricate 3D culture CDM\, cells were cultured into PLA MPs. MPs were produced by jet break-up method\, and their size distribution was calculated by ImageJ whereas their porosity was imaged under SEM. Moreover\, MPs were functionalized with fibronectin to enhance the cell adhesion. hMSCs/hAMSCs were seeded on MPs in a spinner flask for 8 hours. Then\, cell-seeded MPs were cultured for 2 weeks to produce CDM. The cellular viability and cell seeding in the MPs were evaluated. The ECM production before and after decellularization was evaluated by BCA\, hydroxyproline\, SEM\, qRT-PCR\, and immunofluorescence. Values were normalized by the total DNA. Microtissues and cells on 2D culture were also decellularized with 50mM NH4OH\, 0.05% TritonX-100 solution and characterized. \nBased on our results\, for hDF cells; Ficoll\, TGFβ-1 and Ascorbic acid combination\, and also ascorbic acid alone treatments increased total protein and total collagen production. For BM-hMSCs\, total collagen and protein after 2-weeks incubation was increased significantly in the presence of Ascorbic acid condition on the fibronectin coated MPs. AA increased total protein and total collagen production for hAMSCs at 3D culture. \nCDMs are promising and tunable biomaterials to establish 3D in vitro tumor models for cancer research. This platform possess a powerful potential for testing anti-cancer drugs  for personalized medicine in the coming years. \n\nExploring the potential of Galleria mellonella for the study of bacterial infections\nJoana Admella\, Bacterial Infections: Antimicrobial Therapies Group \nBacterial infections are becoming more threatening every day. Pathogens such as Pseudomonas aeruginosa\, Staphylococcus aureus\, Mycobacterium abscessus\, or Burkholderia cenocepacia pose significant challenges due to antimicrobial resistance. Our group has extensive experience in studying pathogenic microorganisms\, with a focus on understanding bacterial virulence and biofilm formation. \nThe insect Galleria mellonella is an alternative animal model widely used for studying bacterial infections and evaluating the toxicity of various molecules and materials. It presents a wide range of advantages\, including low cost\, easy maintenance\, and lack of ethical constraints. Furthermore\, very precise doses can be injected\, facilitating the testing of diverse treatments like antibiotics\, nanomedicines\, or even bacteriophages. Notably\, their innate immune system closely resembles that of mammals\, encompassing both cellular and humoral defenses. These features make Galleria mellonella a very valuable model for investigating host-pathogen interactions\, infection dissemination\, and immune response. Here\, we present an overview of this animal model\, showing a variety of methodologies and applications that have enhanced our understanding of bacterial infections and expanded our knowledge of this insect.
URL:https://ibecbarcelona.eu/es/event/phd-discussions-gulsun-bagci-and-joana-admella/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240412T100000
DTEND;TZID=Europe/Madrid:20240412T110000
DTSTAMP:20260430T160231
CREATED:20240229T104756Z
LAST-MODIFIED:20240229T104756Z
UID:115723-1712916000-1712919600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Kevin Braeckmans
DESCRIPTION:Delivering effector molecules in cells in vitro and ex vivo by photoporation.\nKevin Braeckmans\, Biophotonics Research Group\, Lab. General Biochemistry and Physical Pharmacy\, Ghent University\, Belgium \nDelivery of bioactive compounds\, such as proteins and nucleic acids\, into cells in vitro or ex vivo is a generic requirement for many applications in the life sciences\, such as for the engineering of therapeutic cells. Physical delivery methods are attractive in this context as they are well-controlled\, and can accommodate a broad variety of effector molecules and cell types. Photoporation is such a recently developed physical delivery technology which combines laser stimulation with photothermal nanoparticles. Localized thermal effects upon laser irradiation can create pores in the cell membrane\, allowing the influx of external molecules in cells. Importantly\, photoporation is very gentle to cells\, resulting in excellent cell viability and preservation of a cell’s phenotype and functionality. In this presentation I will give an overview of the most notable work that we performed on photoporation as a next-generation transfection technology in the past decade. \n\nKevin Braeckmans first studied physics before doing his doctoral studies in pharmaceutical sciences at Ghent University in Belgium. From early on he was passionate about developing biophotonics technologies for drug delivery and diagnostics. In 2008 he was appointed professor at Ghent University as the group leader of the Bio-Photonics Research Group. In 2015 he received a prestigious ERC Consolidator Grant and became full professor in 2018. His research presently focuses on studying biological barriers to nanomedicines by advanced microscopy techniques\, and combining light with nanoparticles to enable light-triggered drug delivery and related therapeutic applications. He is a co-author of >250 publications\, Clarivate Highly Cited Author in 2022 and 2023\, and co-inventor of 17 patent applications. Presently he is a co-founder and CSO/CTO of the spin-off company Trince.
URL:https://ibecbarcelona.eu/es/event/ibec-seminar-kevin-braeckmans/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240412T150000
DTEND;TZID=Europe/Madrid:20240412T170000
DTSTAMP:20260430T160231
CREATED:20240212T115203Z
LAST-MODIFIED:20240212T115203Z
UID:115460-1712934000-1712941200@ibecbarcelona.eu
SUMMARY:BMBC meeting
DESCRIPTION:Please mark your calendars! The next BMBC meeting will be held on Friday 12th of April 2024\, from 3-6pm at PRBB\, Marie Curie Room. \n  \nFor this edition we will have an external speaker\, Michael Healy from Queensland University\, Australia. Michael is a postdoc in the group of Brett Collins\, and he has recently published the structure of the whole Commander complex\, involved in endosomal recycling to the plasma membrane (Healy et al.\, Cell\, 2023). We’re sure his talk will be highly interesting for the whole community and we strongly count on your participation. \nWe further thank Albert Pol who invited Michael and Oriol Gallego who is hosting him at PRBB for the help in coordinating Michael’s talk with our BMBC event. \n\n \nHere is a preliminary program \n\n15h – 15h45 Michael Healy (Brett Collins group\, Queensland University) \nUnravelling the Molecular Architecture of the Commander Complex.  \n15h45 – 16h15 Jessica Angulo-Capel (Felix Campelo lab\, ICFO) \nSpatiotemporal Dynamics of Protein Export at the Golgi Apparatus Resolved by Single Particle Tracking \n16h15-16h45     —–    Coffee Break    —— \n16h45-17h15 Albert Herms (Albert Pol group\, IDIBAPS-UB) \nEpithelioids: Self-sustaining 3D epithelial cultures to study long-term cellular processes \n17h15-17h45 Laura Ferigle (Raúl Estévez group\, IDIBELL-UB) \nInsights into MLC pathophysiology by biochemical and structural studies \n  \nMore details will follow soon. Feel free to visit our website and advertise it to your colleague\, they can read the program there and subscribe to the googlegroup. \nBMBC | bmbc (felixcampelo.wixsite.com) \n \n \nLooking forward to see many of you there!
URL:https://ibecbarcelona.eu/es/event/bmbc-meeting/
LOCATION:PRBB (Parc de Recerca Biomèdica de Barcelona)\, Marie Curie Room (PRBB inner square)
CATEGORIES:Joint seminar / workshop / symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240415T180000
DTEND;TZID=Europe/Madrid:20240415T190000
DTSTAMP:20260430T160231
CREATED:20240404T084618Z
LAST-MODIFIED:20240408T155030Z
UID:116553-1713204000-1713207600@ibecbarcelona.eu
SUMMARY:La ricerca Italiana a Barcellona
DESCRIPTION:«La ricerca italiana a Barcellona – Nuovi metodi per comprendere le malattie neurodegenerative.» \nThe Consulate General of Italy will present Dr. Benedetta Bolognesi with the «Cavaliere dell’ordine della Stella» medal in recognition of her career. \nIn addition\, Dr Benedetta Bolognesi\, Group Leader of Protein Phase Transitions in Health and Disease\n\, Prof. Josep Samitier\, Director of IBEC and Prof. Giuseppe Battaglia\, group leader of Molecular Bionics group will discuss Italian research: new methods to fight neurodegenerative diseases. \nThis event will be mainly in Italian. \nInformation here.
URL:https://ibecbarcelona.eu/es/event/la-ricerca-italiana-a-barcellona/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Symposium / Conference / Congress
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240419T163000
DTEND;TZID=Europe/Madrid:20240419T183000
DTSTAMP:20260430T160231
CREATED:20240409T161611Z
LAST-MODIFIED:20240409T161611Z
UID:116842-1713544200-1713551400@ibecbarcelona.eu
SUMMARY:HeLa et al.
DESCRIPTION:HeLa et al.\n\n\n\n\nA video essay by TESS MARSCHNER\n\n\n\n\nBarcelona\, 2024\, 12:00 min (ENG) Technical Support: Julio César Palacio\n\n\n\n\nInaugural event: \nFriday\, April 19th at 4:30PM\nParc Científic de Barcelona · Carrer Baldiri Reixac\, 4-8\, Dolors Aleu room \n\n\n\n\n“HeLa et al.” is the result of the creative process carried out by visual artist Tess Marschner during her artistic residency at the Institute of Bioengineering of Catalonia (IBEC). \nIn her predominantly videographic and research-based works\, she delves into the impact of scientific and theoretical knowledge on social dynamics. Her exploration focuses on feminist subjects\, non-human entities and animal actors. \nThe video essay titled “HeLa et al.” serves as a contemplation on female and reproductive (parts of) bodies within techno-sciences: Henrietta Lacks’ immortal cell line\, the cloned sheep Dolly\, wombs\, eggs and mice show up both as technical components of the scientific realm as well as entities that challenge the notion of the human\, raising ethical considerations. \n“HeLa et al.” was developed during her Artistic Residency at IBEC 2023/24. \n\n\n\n\nEVENT AGENDA: 4:30PM-6:30PM\n\n\n\n\nWelcome by Teresa Sanchis · Head of Strategy at IBEC.\nIntroduction by Tess Marschner\, Artist in Residence at IBEC.\nVideo Screening.\nPanel discussion & Q&A.\nVideo Screening.\nToast and final words by Josep Samitier\, Director of IBEC.\n\nRegister here.
URL:https://ibecbarcelona.eu/es/event/hela-et-al/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:Social / Internal / PhD Committee
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240424T090000
DTEND;TZID=Europe/Madrid:20240426T150000
DTSTAMP:20260430T160231
CREATED:20240116T095022Z
LAST-MODIFIED:20240116T095022Z
UID:114152-1713949200-1714143600@ibecbarcelona.eu
SUMMARY:3rd edition EMBL-IBEC Conference ENGINEERING MULTICELLULAR SYSTEMS
DESCRIPTION:3rd edition EMBL – IBEC Conference\n\n\n\n\nENGINEERING MULTICELLULAR SYSTEMS\n\n\n\n\nEMBL and IBEC aim to contribute to the discussion on challenges and opportunities in the expanding field of engineered multicellular systems. \nRecent breakthroughs in stem cell biology\, organ-on-chip assays\, 3-D bioprinting\, and cell mechanobiology have revolutionized our ability to design and assemble multicellular living systems\, from organoids to embryos. \nThis biennial series will focus on how engineering multicellular living systems is boosting our understanding of tissue and organ function\, with applications in disease modelling\, drug screening\, and tissue engineering. \n#EMBL_IBECConf \nEMBL-IBEC Conference – ENGINEERING MULTICELLULAR SYSTEMS (ibecbarcelona.eu)
URL:https://ibecbarcelona.eu/es/event/3rd-edition-embl-ibec-conference-engineering-multicellular-systems/
LOCATION:Barcelona Biomedical Research Park (PRBB)\, Dr. Aiguader 88 \, Barcelona\, 08003
CATEGORIES:IBEC Symposium / Conference / Congress
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