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DTSTART;TZID=Europe/Madrid:20241213T100000
DTEND;TZID=Europe/Madrid:20241213T110000
DTSTAMP:20260430T065008
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UID:121784-1734084000-1734087600@ibecbarcelona.eu
SUMMARY:PhD Discussion: Anna Panteleeva and Miguel Gonzalez Martin
DESCRIPTION:Advancing Neurodegenerative Disease Research with Enhanced Brain-on-a-Chip Technology and Integrated Biosensor Systems \nAnna Panteleeva – Nanobioengineering\nNeurodegenerative disorders (NDDs)\, such as Alzheimer’s disease\, remain a critical global health challenge. A key obstacle in drug development is the blood-brain barrier (BBB)\, which plays a crucial role in regulating the exchange of substances between the bloodstream and the brain. While the BBB protects the brain\, its dysfunction contributes to NDD progression\, and it hinders drug delivery\, leaving most therapeutic candidates unsuccessful in clinical trials.\nTraditional animal models have provided valuable insights into NDDs\, but they fall short in fully replicating the complexity of human neural responses. Brain-on-a-chip (BoC) technology has emerged as a promising tool\, offering controlled environments to study neuronal networks. Integrating a BBB component into BoC systems significantly enhances their physiological relevance\, enabling the study of complex BBB properties.\nOur research advances BoC technology by combining a microfluidic device\, multi-electrode array (MEA) technology and biosensors to create a comprehensive BBB model. By co-culturing endothelial cells\, pericytes\, astrocytes\, and neurons\, we replicate key BBB elements and neural interactions. This setup allows real-time monitoring of BBB permeability and neural activity via MEA electrodes\, and neuronal degradation using biosensors. Preliminary results demonstrate promising outcomes\, though further optimization is required.\nThis innovative approach improves the physiological relevance of BoC systems and accelerates drug development and personalized therapies for NDDs\, providing a pathway toward more effective treatments. \nDesigning synthetic mechanosensitive molecules for the mechanical control of cellular transcription \nMiguel Gonzalez Martin – Cellular and Molecular Mechanobiology\nCells sense mechanical signals in the process of mechanotransduction\, activating pathways that govern cell behavior. However\, it remains a challenge to engineer mechanotransduction pathways in a controllable and predictable manner. Here we aim to engineer a synthetic mechanosensitive transcription factor (msTTA). To this end\, we exploit the force induced changes in nuclear transport\, linking nuclear mechanical perturbations to gene expression. To do so\, we are mechanically tuning the passive and facilitated transport properties of the synthetic msTTA. Through this we aim to recapitulate the localization behavior of endogenous mechanosensitive proteins such as YAP or Twist\, but with a synthetic factor that activates genes of choice in a controlled way. Optimizing our reporter cells\, we have set up a novel screening platform with substrates of different rigidity\, from which we expect to identify highly mechanosensitive TF candidates that function in a tunable manner\, as well as to elucidate which features make a transcription factor mechanosensitive. Overall\, we expect to unlock precise transcriptional control through mechanical forces\, and a state-of-the-art directed evolution platform for msTTAs. With the simplicity of this engineered regulatory module\, we expect to describe the minimal elements of mechano-regulation of gene expression\, as well as enabling the use of mechanotransduction in gene circuits control. This will open the field to use mechanotransduction approaches for complex synthetic biology applications.
URL:https://ibecbarcelona.eu/es/event/phd-discussion-3/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
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DTSTART;TZID=Europe/Madrid:20241213T100000
DTEND;TZID=Europe/Madrid:20241213T140000
DTSTAMP:20260430T065008
CREATED:20241211T123730Z
LAST-MODIFIED:20241211T123730Z
UID:122421-1734084000-1734098400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Betsy Verónica Arévalo Jaimes
DESCRIPTION:Biofilms microbianos: virulencia e interacciones hongo-bacteria\nBetsy Verónica Arévalo Jaimes\, Bacterial infections and Antimicrobial Therapies group \nThis thesis defence will take place at the Aula de Grados de la Facultad de Biología de la Universidad de Barcelona.\nFriday 13th December at 10:00h
URL:https://ibecbarcelona.eu/es/event/phd-thesis-defence-betsy-veronica-arevalo-jaimes/
CATEGORIES:PhD Thesis Defence
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DTSTART;TZID=Europe/Madrid:20241217T150000
DTEND;TZID=Europe/Madrid:20241217T160000
DTSTAMP:20260430T065008
CREATED:20241204T092845Z
LAST-MODIFIED:20241204T092845Z
UID:122171-1734447600-1734451200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Yuval Ebenstein
DESCRIPTION:Beyond NGS: A toolbox for single-molecule epigenetic analysis of DNA\nProf. Yuval Ebenstein\, Department of Physical Chemistry\, Department of Biomedical Engineering\, Founder\, Innovation and Entrepreneurship Center Tel Aviv University\, Israel. \nDNA sequencing (NGS) is revolutionizing all fields of biological research. Still\, it fails to extract the full range of information associated with genetic material and cannot resolve important variations between genomes. The information content of the genome extends beyond the base sequence in the form of chemical modifications such as DNA methylation or chromosomal association with DNA-binding proteins (chromatin). For the last decade\, my lab has been developing tools for genomic analysis at the single-cell and single-molecule levels. I will show how the physical extension of long DNA molecules in nanofluidic channels reveals this information in the form of a linear\, optical\, or electrical “barcode\,” like beads threaded on a string\, where each bead represents a distinct type of observable.  I’ll present a biochemical and physical toolbox for mapping epigenetic modifications in the genome and demonstrate its application in clinical cancer research. Finally\, I will talk about a DNA chip developed in the lab and the adventure of building a startup based on this technology. \n  \nShort Bio:\nProf. Yuval Ebenstein is a scientist and entrepreneur with years of experience in translational research. Yuval is head of the NanoBioPhotonix Lab and the founder of the Tel Aviv University Entrepreneurship Center. In his lab\, Yuval combines Chemistry\, Physics\, Biology\, and bioinformatics in order to study the human genome. His lab explores genomes utilizing tools and reagents from the realm of nano-technology\, zooming in on single cells\, single chromosomes\, and single molecules. Yuval is the winner of two ERC awards for developing genomic technologies and is the founder of JaxBio\, a liquid biopsy methylation-based diagnostics startup. 
URL:https://ibecbarcelona.eu/es/event/ibec-seminar-prof-yuval-ebenstein/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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