Monika E. Dolega, Institute for Advanced Biosciences IAB, INSERM U1209, CNRS UMR5309, University Grenoble-Alpes, Grenoble, France<\/em><\/p>\n <\/p>\n Epithelial tissues experience constant mechanical stimuli tied to normal physiological functions, but how they maintain homeostasis under such dynamic conditions remains unclear. Our previous RNAseq study on in-plane compressed epithelial monolayers revealed altered transcripts of ribosomal proteins essential for ribosome biogenesis in nucleoli\u2014membrane-less, sub-nuclear biocondensates that challenge classical mechanotransduction concepts. Although few studies confirm nucleolar sensitivity to external cues, detailed mechanisms are lacking. Using advanced microscopy, omics, and biophysical approaches, we uncover a new mechanism of nucleolar mechano-adaptation. Mechanical confinement over minutes reorganizes nucleolar structure and downregulates pre-rRNA transcription. Central to this process is the nucleolar protein Nucleolin, which translocates to perform two roles: it leaves the rDNA promoter region to down-regulate ribosome biogenesis and participates in DNA repair at damage sites caused by compression. This study introduces the nucleolus as a mechano-sensitive organelle, advancing mechanobiology and cancer research by revealing a new potential therapeutic target<\/p>","excerpt":"","slug":"ibec-seminar-monika-e-dolega","image":false,"all_day":false,"start_date":"2026-02-16 11:30:00","start_date_details":{"year":"2026","month":"02","day":"16","hour":"11","minutes":"30","seconds":"00"},"end_date":"2026-02-16 12:30:00","end_date_details":{"year":"2026","month":"02","day":"16","hour":"12","minutes":"30","seconds":"00"},"utc_start_date":"2026-02-16 10:30:00","utc_start_date_details":{"year":"2026","month":"02","day":"16","hour":"10","minutes":"30","seconds":"00"},"utc_end_date":"2026-02-16 11:30:00","utc_end_date_details":{"year":"2026","month":"02","day":"16","hour":"11","minutes":"30","seconds":"00"},"timezone":"Europe\/Madrid","timezone_abbr":"CET","cost":"","cost_details":{"currency_symbol":"\u20ac","currency_code":"USD","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":true,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"IBEC Seminar","slug":"ibec-seminar","term_group":0,"term_taxonomy_id":108,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":338,"filter":"raw","term_order":"0","id":105,"urls":{"self":"https:\/\/ibecbarcelona.eu\/es\/wp-json\/tribe\/events\/v1\/categories\/105","collection":"https:\/\/ibecbarcelona.eu\/es\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":{"id":128348,"author":"54","status":"publish","date":"2025-09-15 11:02:53","date_utc":"2025-09-15 09:02:53","modified":"2025-09-15 11:02:53","modified_utc":"2025-09-15 09:02:53","url":"https:\/\/ibecbarcelona.eu\/recinto\/baobab-room-floor-11-tower-1\/","venue":"Baobab room, Floor 11, Tower 1","slug":"baobab-room-floor-11-tower-1","json_ld":{"@type":"Place","name":"Baobab room, Floor 11, Tower 1","description":"","url":"","address":{"@type":"PostalAddress"},"telephone":"","sameAs":""},"show_map":true,"show_map_link":true,"global_id":"ibecbarcelona.eu\/es\/?id=128348","global_id_lineage":["ibecbarcelona.eu\/es\/?id=128348"]},"organizer":[],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Ibec Seminar. Monika E. Dolega","description":"<p>Nucleolar mechano-adaptation and its role in epithelial homeostasis Monika E. Dolega, Institute for Advanced Biosciences IAB, INSERM U1209, CNRS UMR5309, University Grenoble-Alpes, Grenoble, France Epithelial tissues experience constant mechanical ... <a title="Ibec Seminar. Monika E. Dolega" class="read-more" href="https:\/\/ibecbarcelona.eu\/es\/event\/ibec-seminar-monika-e-dolega\/" aria-label="More on Ibec Seminar. Monika E. Dolega">Read more<\/a><\/p>\\n","url":"https:\/\/ibecbarcelona.eu\/es\/event\/ibec-seminar-monika-e-dolega\/","eventAttendanceMode":"https:\/\/schema.org\/OfflineEventAttendanceMode","eventStatus":"https:\/\/schema.org\/EventScheduled","startDate":"2026-02-16T11:30:00+01:00","endDate":"2026-02-16T12:30:00+01:00","location":{"@type":"Place","name":"Baobab room, Floor 11, Tower 1","description":"","url":"","address":{"@type":"PostalAddress"},"telephone":"","sameAs":""},"performer":"Organization"}}