{"id":116248,"date":"2024-03-04T16:30:43","date_gmt":"2024-03-04T15:30:43","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/industry-and-hospitals\/capabilities\/the-capabilities-in-designing-therapies-based-on-nanoparticles-vesicles\/"},"modified":"2024-07-10T11:55:58","modified_gmt":"2024-07-10T09:55:58","slug":"designing-nanomaterials","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/es\/industry-and-hospitals\/capabilities\/designing-nanomaterials\/","title":{"rendered":"Nanomaterials"},"content":{"rendered":"\n

IBEC has specialized expertise in designing nanoparticle-based therapies encompassing fabrication, characterization, functionalization, behavior modeling, and in vivo<\/em>\/in vitro<\/em> testing.<\/h4>\n\n\n\n

Focus Areas:<\/strong><\/p>\n\n\n\n

    \n
  • Tissue Regeneration<\/li>\n\n\n\n
  • Immunology<\/li>\n\n\n\n
  • Infections<\/li>\n\n\n\n
  • Neurodegenerative Diseases<\/li>\n\n\n\n
  • Cancer<\/li>\n<\/ul>\n\n\n
    \n

    EXPERTISE DETAILS<\/h2>\n
    \n\n\n\n\n

    <\/p>\n\n\n\n

      \n
    1. Modeling:<\/strong>\n
        \n
      • Modeling nanoparticles’ pharmacokinetics and pharmacodynamics in vitro<\/em> and in silico<\/em> using computational biophysics techniques such as Molecular Dynamics, Coarse-Grain modeling, and Binding Energy calculations.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n
          \n
        1. Design, S<\/strong>ynthesis and Functionalization:<\/strong>\n
            \n
          • Synthesis and functionalization of nanoparticles using biocompatible polymers or co-polymers (e.g., PEG\/PLA), mesoporous silica, liposomes, micelles, and others.<\/li>\n\n\n\n
          • Use of decorating and targeting agents such as antibodies, aptamers, peptides, enzymes, or other proteins.<\/li>\n\n\n\n
          • Bioactive nano\/micro particles promoting recruitment of progenitor cells, angiogenesis, and antimicrobial effects.<\/li>\n\n\n\n
          • Development of surface deposition protocols.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n
              \n
            1. Characterization:<\/strong>\n
                \n
              • Multiparametric nondestructive measurement of mechanical and electrical properties of nanoparticles<\/li>\n\n\n\n
              • Characterization at the liquid-solid interface on a micro scale.<\/li>\n\n\n\n
              • Analysis of high polydispersity samples.<\/li>\n\n\n\n
              • High-throughput physical multiparametric characterization of single nanoparticles.<\/li>\n\n\n\n
              • Motion characterization of nanomotors in simulated matrices.<\/li>\n\n\n\n
              • Use of Galleria mellonella as a model to assess the toxicity of nanomaterials, including nanoparticulated formulations. <\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n
                  \n
                1. Nanoparticle-Based Therapies:<\/strong>\n
                    \n
                  • Design of therapies against:\n
                      \n
                    • Bacterial Infections: Enhancement of existing antibiotics and development of novel approaches based on synthetic cells for anti-biofilm purposes.<\/li>\n\n\n\n
                    • Malaria and Leishmaniasis: Improvement of current antimalarial drugs and targeting specific pathogen phases.<\/li>\n\n\n\n
                    • Bladder cancer, Pseudomyxoma Peritonei and joint diseases: use of a novel drug delivery approach based on biocompatible and biodegradable enzyme-powered nanomotors.<\/li>\n\n\n\n
                    • Skin burns, chronic wounds and bone tissue disorders<\/li>\n<\/ul>\n<\/li>\n\n\n\n
                    • Nano-drug targeting based on cell phenotype. Tested applications: Immune system targeting for Tuberculosis and Bacterial Infections, and Blood-Brain-Barrier targeting for Alzheimer and Multiple Sclerosis.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

                      IBEC has specialized expertise in designing nanoparticle-based therapies encompassing fabrication, characterization, functionalization, behavior modeling, and in vivo\/in vitro testing. Focus Areas:<\/p>\n","protected":false},"author":4,"featured_media":116236,"parent":115866,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-116248","page","type-page","status-publish","has-post-thumbnail"],"yoast_head":"\nNanomaterials - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Experience in designing therapies based on the nanoparticles\/vesicles, that include the fabrication, characterization, functionalization, behavior modelling and in vivo\/vitro testing. 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