{"id":116265,"date":"2024-03-04T16:34:31","date_gmt":"2024-03-04T15:34:31","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/industry-and-hospitals\/capabilities\/drug-discovery-and-development\/"},"modified":"2024-07-10T11:52:25","modified_gmt":"2024-07-10T09:52:25","slug":"drug-discovery-and-development","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/es\/industry-and-hospitals\/capabilities\/drug-discovery-and-development\/","title":{"rendered":"Drug discovery and development"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Extensive experience in designing photopharmacological small molecules and supramolecular drugs, <em>in silico<\/em> and <em>in vitro<\/em> compound screening, and target validation projects related to cancer, infectious diseases, CNS related diseases and photopharmacology. Several disease models are available for testing new treatments and new disease modelling is possible.<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Custom photopharmacological concept drug design, synthesis and full light-response study.<\/li>\n\n\n\n<li><em>In silico<\/em> compounds screening against a protein target and binding parameters calculation.<\/li>\n\n\n\n<li>PoC demonstration on wound models of infection and standard animal models (Galleria mellonella, Drosophila, etc).<\/li>\n\n\n\n<li>Multidisciplinary platform for drug screening and toxicological studies.<\/li>\n<\/ul>\n\n\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">EXPERTISE IN SPECIFIC AREAS<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Central nervous system:<\/strong>\n<ul class=\"wp-block-list\">\n<li>D<span style=\"font-size: inherit; background-color: var(--base-3); color: var(--contrast); font-family: -apple-system, system-ui, BlinkMacSystemFont, &quot;Segoe UI&quot;, Helvetica, Arial, sans-serif, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Symbol&quot;;\">eep mutational screening of proteins\/peptides: a high-throughput method for studying mechanisms of pathogenesis of all amyloid associated disease.<\/span><\/li>\n\n\n\n<li><span style=\"font-size: inherit; background-color: var(--base-3); color: var(--contrast); font-family: -apple-system, system-ui, BlinkMacSystemFont, &quot;Segoe UI&quot;, Helvetica, Arial, sans-serif, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Symbol&quot;;\">Screening for modifiers of protein aggregation, that can be small molecules, peptides or compounds, potentially applicable for CNS related diseases like Alzheimer\u2019s disease, Parkinson\u2019s disease, Amyotrophic lateral sclerosis, Type-II Diabetes or Fronto-temporal Dementia. Available for small scale (10 sequences) or big scale (100,000 sequences) libraries.<\/span><\/li>\n\n\n\n<li><span style=\"font-size: inherit; background-color: var(--base-3); color: var(--contrast); font-family: -apple-system, system-ui, BlinkMacSystemFont, &quot;Segoe UI&quot;, Helvetica, Arial, sans-serif, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Symbol&quot;;\">In vivo correlation of protein mutation with aggregate nucleation and in vivo assessment of toxicity and stability of expressed proteins and peptides.\u00a0<\/span><\/li>\n\n\n\n<li>Efficacy assays in small and large animals for vision or navigational sense testing.\u00a0<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Infectious diseases:<\/strong>\n<ul class=\"wp-block-list\">\n<li>D<span style=\"font-size: inherit; background-color: var(--base-3); color: var(--contrast); font-family: -apple-system, system-ui, BlinkMacSystemFont, &quot;Segoe UI&quot;, Helvetica, Arial, sans-serif, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Symbol&quot;;\">rug screening for antimicrobial resistance bacteria using a microfluidic platform for patience-based biofilm growth and monitorization, mimicking real\/life clinical environment.<\/span><\/li>\n\n\n\n<li><span style=\"font-size: inherit; background-color: var(--base-3); color: var(--contrast); font-family: -apple-system, system-ui, BlinkMacSystemFont, &quot;Segoe UI&quot;, Helvetica, Arial, sans-serif, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Symbol&quot;;\">Determination of the antimicrobial and antibiofilm formation activity on relevant supports (tubes, catheters, etc), under static or flow conditions, isolated or forming biofilms that can be mono or polymicrobial. Experience with Bacteria and Yeast: S. aureus, S. aureus methicillin-resistant, S. epidermis, Strep. mutans, E. faecalis, E. coli, P. aeruginosa, Mycobacterium, Klepsiella, Acinetobacter, Candida, etc.<\/span><\/li>\n\n\n\n<li><span style=\"font-size: inherit; background-color: var(--base-3); color: var(--contrast); font-family: -apple-system, system-ui, BlinkMacSystemFont, &quot;Segoe UI&quot;, Helvetica, Arial, sans-serif, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Symbol&quot;;\">Experience with anti-Biofilm phage therapy.<\/span><\/li>\n\n\n\n<li>Target validation projects of antimalaria\/leishmania compounds and treatments, assessing also the prophylactic activity, the anticoagulant or hemolytic activity and the efficacy in small animal models of infection.\u00a0<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Extensive experience in designing photopharmacological small molecules and supramolecular drugs, in silico and in vitro compound screening, and target validation projects related to cancer, infectious diseases, CNS related diseases and &#8230; <a title=\"Drug discovery and development\" class=\"read-more\" href=\"https:\/\/ibecbarcelona.eu\/es\/industry-and-hospitals\/capabilities\/drug-discovery-and-development\/\" aria-label=\"More on Drug discovery and development\">Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":116230,"parent":115866,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-116265","page","type-page","status-publish","has-post-thumbnail"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Drug discovery and development - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Extensive experience in designing photopharmacological small 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