{"id":19421,"date":"2015-09-08T14:10:47","date_gmt":"2015-09-08T12:10:47","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?page_id=19421"},"modified":"2021-12-30T13:05:01","modified_gmt":"2021-12-30T12:05:01","slug":"nanoscopy-for-nanomedicine","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/es\/research-groups\/former-groups\/nanoscopy-for-nanomedicine\/","title":{"rendered":"Nanoscopy for nanomedicine"},"content":{"rendered":"<hr \/>\n<p><img decoding=\"async\" class=\"size-full wp-image-29219 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/07\/lalbertazzi.jpg\" alt=\"\" width=\"800\" height=\"\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1500px; --smush-placeholder-aspect-ratio: 1500\/469;\" \/><\/p>\n<div style=\"clear: both;\"><\/div>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">About<\/h2>\n<div class=\"tabcontent\">\n\n<p><strong>The main goal of our group is to use Super Resolution Microscopy (nanoscopy) to visualize and track in living cells and tissues self-assembled nanomaterials with therapeutic potential (nanomedicine). <\/strong><\/p>\n<figure id=\"attachment_29370\" aria-describedby=\"caption-attachment-29370\" style=\"width: 290px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"wp-image-29370 size-medium lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_1-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_1-300x300.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_1-150x150.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_1-130x130.jpg 130w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_1.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_1-45x45.jpg 45w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/300;\" \/><figcaption id=\"caption-attachment-29370\" class=\"wp-caption-text\">TEM image of novel self-assembled nanofibers synthesized in the group.<\/figcaption><\/figure>\n<p>The understanding of materials-cell interactions is the key towards the development of novel nanotechnology-based therapies for treatment of cancer and infectious diseases.<br \/>\nOur group aims to use a multidisciplinary approach, at the interface of chemistry, physics and biology, to develop novel nanomaterials for the treatment of cancer and infectious diseases.<\/p>\n<p>We aim at the development of novel nanocarriers for drug delivery based on self-assembly, i.e. able to build themselves. Molecular self-organization is ubiquitous in the biological world and represents for us a source of inspiration for the design of nanostructures with biomedical potential. In particular we focus on the development of self-assembled nanoparticles and nanofibers able to selectively target diseased cells and deliver locally therapeutic moieties such as drugs and genetic material (e.g. DNA, siRNA, mRNA).<\/p>\n<p><img decoding=\"async\" class=\"alignright size-full wp-image-29371 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_2.jpg\" alt=\"\" width=\"400\" height=\"198\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_2.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_2-300x149.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_2-230x114.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/albertazzi_2016_2-150x74.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/198;\" \/><\/p>\n<h6 class=\"caption\">Right: Nanoparticles interactions with blood components imaged with conventional optical microscopy (left) and super resolution STORM microscopy (right).<\/h6>\n<p>A key point towards the development of novel nanotechnology-based therapies is the understanding of the behavior of nanomaterials in the complex biological environment. Here we use super resolution microscopy to track nanomaterials during their voyage in the biological environment and to visualize the interactions with blood components, immune system and target cells. We make use of a variety of super resolution techniques based on single molecule detection such a stochastic optical reconstruction microscopy (STORM), photoactivated localization microscopy (PALM), point accumulation for imaging in nanoscale topography (PAINT), and single particle tracking (SPT). These methods allow to achieve a resolution down to few nanometers and are therefore ideal to visualize nanosized synthetic objects in the biological environment. Super resolution microscopy provides a molecular picture of structure-activity relations and represent a guide towards the design of innovative materials for nanomedicine.<\/p>\n\n<\/div><h2 class=\"tabtitle\">Staff<\/h2>\n<div class=\"tabcontent\">\n\n\n<p>&nbsp;<\/p>\n\n<\/div><h2 class=\"tabtitle\">Projects<\/h2>\n<div class=\"tabcontent\">\n\n<h5>International grants<\/h5>\n<table width=\"1020\">\n<tbody>\n<tr>\n<td width=\"700\"><strong>NANOSTORM<\/strong> Design of Nanomaterials for Targeted Therapies Guided by Super Resolution Imaging (2018-2023)<\/td>\n<td width=\"250\">ERC, European Commission<\/td>\n<td width=\"70\">Lorenzo Albertazzi<\/td>\n<\/tr>\n<tr class=\"even\">\n<td width=\"700\">THERACAT BIO-orthogonal catalysis for cancer therapy (2018-2022)<\/td>\n<td width=\"250\">MARIE CURIE, European Commission<\/td>\n<td width=\"70\">Lorenzo Albertazzi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>National grants<\/h5>\n<table width=\"1020\">\n<tbody>\n<tr>\n<td width=\"700\"><strong>STROMATARGET \u00b7<\/strong> Pol\u00edmeros supramoleculares dirigidos al microambiente tumoral: validaci\u00f3n mediante t\u00e9cnicas de microscop\u00eda avanzada (2020-2023)<\/td>\n<td width=\"250\">MINECO: Retos investigaci\u00f3n: Proyectos I+D<\/td>\n<td width=\"70\">Silvia Pujals<\/td>\n<\/tr>\n<tr>\n<td width=\"700\">Collaborative Research Projects AOM-BIST<\/td>\n<td width=\"250\">BIST<\/td>\n<td width=\"70\">Lorenzo Albertazzi<\/td>\n<\/tr>\n<tr>\n<td width=\"700\">Understanding and measuring mechanical tumor properties to improve cancer\u00a0 diagnosis, treatment, and survival: Application to liquid biopsies<br \/>\n(2017-2021)<\/td>\n<td width=\"250\">Obra Social La Caixa<\/td>\n<td width=\"70\">Lorenzo Albertazzi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>Finished projects<\/h5>\n<table style=\"width: 765px;\">\n<tbody>\n<tr>\n<td width=\"700\"><strong>NANOVAX<\/strong> Nanovacunas dise\u00f1adas para inmunoterapia antitumoral (2016-2020)<\/td>\n<td width=\"250\">Acciones de Programaci\u00f3n Conjunta Internacional, MINECO<\/td>\n<td width=\"70\">Lorenzo Albertazzi\/Josep Samitier<\/td>\n<\/tr>\n<tr class=\"even\">\n<td>Novel approaches for Pandemic Virus Targeting Using Adaptive Polymers (2015-2017)<\/td>\n<td>AXA Research Fund<\/td>\n<td>Lorenzo Albertazzi<\/td>\n<\/tr>\n<tr class=\"even\">\n<td><strong>TARGETSTORM <\/strong>Nanomateriales para terapias dirigidas contra el c\u00e1ncer visualizados con microscopia de s\u00faper resoluci\u00f3n STORM (2016-2019)<\/td>\n<td>Retos investigaci\u00f3n: Proyectos I+D, MINECO<\/td>\n<td>Silvia Pujals<\/td>\n<\/tr>\n<tr class=\"even\">\n<td>SGR Grups de recerca consolidats (2017-2019)<\/td>\n<td>SGR, AGAUR<\/td>\n<td>Silvia Pujals<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<\/div><h2 class=\"tabtitle\">Publications<\/h2>\n<div class=\"tabcontent\">\n\n<p>(See full publication list in <a href=\"http:\/\/orcid.org\/0000-0002-6837-0812\">ORCID<\/a>)<\/p>\n<div class=\"loadpubs\"><\/div><script>\n    var url=\"https:\/\/ibecbarcelona.eu\/wp-content\/plugins\/ibec\/pubs\/nanoscopy-for-nanomedicine.html\";\n    jQuery(document).ready(function(){\n            jQuery(\".loadpubs\").load(url);\n    });\n    <\/script>\n\n<\/div><h2 class=\"tabtitle\">Equipment<\/h2>\n<div class=\"tabcontent\">\n\n<ul>\n<li><span data-contrast=\"auto\">Nikon NSTORM for TIRF, Super-Resolution imaging and single-molecule tracking\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Nikon Ti2 Widefield microscopy for fast and high-content imaging<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Collaborations<\/h2>\n<div class=\"tabcontent\">\n\n<ul>\n<li>Roey Amir<br \/>\n<em>Tel Aviv University, Israel<\/em><\/li>\n<li>Mika Linden<br \/>\n<em>Ulm University, Germany<\/em><\/li>\n<li>Ilja Voets<br \/>\n<em>Eindhoven University of Technology, The Netherlands<\/em><\/li>\n<li>Giovanni Pavan<br \/>\n<em>SUPSI, Switzerland<\/em><\/li>\n<li>Bruno De Geest<br \/>\n<em>University of Ghent, Belgium<\/em><\/li>\n<li>Salvador Borros<br \/>\n<em>IQS, Barcelona<\/em><\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">News<\/h2>\n<div class=\"tabcontent\">\n\n<p>[wp_show_posts id=\u00bb75038&#8243;]<\/p>\n<p>&nbsp;<\/p>\n\n<\/div><h2 class=\"tabtitle\">Jobs<\/h2>\n<div class=\"tabcontent\">\n\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The main goal of our group is to use Super Resolution Microscopy (nanoscopy) to visualize and track in living cells and tissues self-assembled nanomaterials with therapeutic potential (nanomedicine). The understanding &#8230; <a title=\"Nanoscopy for nanomedicine\" class=\"read-more\" href=\"https:\/\/ibecbarcelona.eu\/es\/research-groups\/former-groups\/nanoscopy-for-nanomedicine\/\" aria-label=\"More on Nanoscopy for nanomedicine\">Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":94495,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-19421","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanoscopy for nanomedicine - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/research-groups\/nanoscopy-for-nanomedicine\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanoscopy for nanomedicine - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"The main goal of our group is to use Super Resolution Microscopy (nanoscopy) to visualize and track in living cells and tissues self-assembled nanomaterials with therapeutic potential (nanomedicine). 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