{"id":29689,"date":"2016-12-23T10:47:44","date_gmt":"2016-12-23T09:47:44","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/es\/investigacion\/biosensors-for-bioengineering-3\/"},"modified":"2016-12-23T10:47:44","modified_gmt":"2016-12-23T09:47:44","slug":"biosensors-for-bioengineering-3","status":"publish","type":"page","link":"https:\/\/ibecbarcelona.eu\/es\/research-groups\/biosensors-for-bioengineering-3\/","title":{"rendered":"Biosensors for bioengineering"},"content":{"rendered":"<hr \/>\n<p><img decoding=\"async\" class=\"alignleft size-full wp-image-29686 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/jramon_2017.jpg\" alt=\"\" width=\"800\" height=\"351\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/jramon_2017.jpg 800w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/jramon_2017-300x132.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/jramon_2017-768x337.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/jramon_2017-230x101.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/05\/jramon_2017-150x66.jpg 150w\" data-sizes=\"(max-width: 800px) 100vw, 800px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800\/351;\" \/><\/p>\n<div style=\"clear: both;\"><\/div>\n<address>The Biosensors for bioengineering group is a junior group under IBEC&#8217;s Tenure Track scheme.<\/address>\n<script> document.title = document.title + '- Javier  Ram\u00f3n  Azc\u00f3n '; <\/script> <div class=\"member\"><div class=\"member-img\"> <img decoding=\"async\" src=\"\"><\/div><h2 class=\"member-name\">Javier  Ram\u00f3n  Azc\u00f3n <\/h2> <div class=\"member-position\">Group Leader\/ICREA Research Pr<\/div> <div class=\"member-info\"><div class=\"member-phone icon-left\"><span class=\"dashicons dashicons-smartphone\"><\/span>934 02 45 84<\/div> <div class=\"member-email icon-left\"><span class=\"dashicons dashicons-email-alt\"><\/span>jramon<img decoding=\"async\" data-src=\"\/img\/arroba.png\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\">ibecbarcelona.eu<\/div><div class=\"member-email icon-left\"><span class=\"dashicons dashicons-admin-users\"><\/span><a href=\"\/member\/?empID=1030&Javier+Ram%C3%B3n+Azc%C3%B3n\">Researcher profile<\/a><\/div><\/div><\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2513\">And\u00fajar S\u00e1nchez, F\u00e9lix<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3235\">Bader , Jannis Ben<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2892\">Bauzon , Petra<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2746\">Caboche , Timoth\u00e9e<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2681\">Castro , Natalia<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=1531\">Fernandez Costa, Juanma<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=1258\">Fern\u00e1ndez Garibay, Xiomara Gislen<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=1834\">Ferret Mi\u00f1ana, Ainhoa<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3139\">Fornaro , Marta<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3213\">Guillera P\u00e9rez, Elia<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3211\">Junc\u00e0 Morch\u00f3n, Bernat<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3251\">Lannoy , Camille<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3221\">Lenar , Nikola<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3262\">Marco Garrido, Pablo<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3185\">Moncada Madrazo, Sof\u00eda Idalia<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2752\">Mor\u00f3n Ros, Samantha<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3142\">M\u00e0rquez Puchol, Oscar<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2738\">Ninfali , Chiara<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3215\">Qalouma , Mariam<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=1030\">Ram\u00f3n Azc\u00f3n, Javier<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=1769\">Riso Fresno, Luciano<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2779\">Rodr\u00edguez Gallo, Carolina<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2437\">Ruiz Guti\u00e9rrez, Mart\u00edn<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2660\">Sabater Arc\u00eds, Maria<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=3183\">Sarria G\u00f3mez, Gabriel<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2018\">Tejedera Villafranca, Ainoa<\/a> <\/div><div class=\"group-staff-member\"><a href=\"\/member\/?empID=2712\">Torabi Goodarzi, Mehdi<\/a> <\/div>\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">About<\/h2>\n<div class=\"tabcontent\">\n\n<figure id=\"attachment_26912\" aria-describedby=\"caption-attachment-26912\" style=\"width: 340px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-full wp-image-26912 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon1_web.jpg\" width=\"350\" height=\"262\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon1_web.jpg 350w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon1_web-300x225.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon1_web-174x130.jpg 174w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon1_web-150x112.jpg 150w\" data-sizes=\"(max-width: 350px) 100vw, 350px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/262;\" \/><figcaption id=\"caption-attachment-26912\" class=\"wp-caption-text\">Formation of 3D ESC aggregates in GelMA hydrogel using dielectrophoresis (DEP). The stem cells in the GelMA prepolymer were introduced into the 100 \u00b5m height chamber and localized by DEP forces to the low electric field regions within the microelectrodes. The GelMA prepolymer was then exposed to UV light, embedding the cells in a stable microscale organization. Scale bar shows 100 \u00b5m.<\/figcaption><\/figure>\n<p><strong>Drug discovery pathway relies heavily on <em>in vivo<\/em> animal models and <em>in vitro<\/em> cell mediums. In the case of animal models we have not only some ethical problems but also the ability to extrapolate data to human conditions is limited and <em>in vitro<\/em> platforms often do not simulate the complex cell\u2013cell and cell\u2013matrix interactions crucial for regulating cell behaviour. <\/strong><\/p>\n<p>The Biosensors for Bioengineering group is focused in a new line of research that has become of extreme importance in the last years. The idea is to integrate biosensor technology and nanotechnology with stem cell research and with tissue engineering. Engineered tissues are integrated with biosensing technology to obtain microdevices for detecting cellular responses to external stimuli, monitoring the quality of the microenvironment (e.g., metabolites, nutrients), and supporting diverse cellular requirements. This research on 3D-functional engineered tissues is expected to develop knowledge of tissue construction and their functions and relation with some human diseases. Integration of fully functional tissues with microscale biosensor technology allowed us to obtain \u201corgans-on-a-chip\u201d. These chips could be used in pharmaceutical assays and could be a step toward the ultimate goal of producing <em>in vitro<\/em> drug testing systems crucial to the medicine and pharmaceutical industry.<\/p>\n<p><img decoding=\"async\" class=\"size-full wp-image-26906 alignleft lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon2_web.jpg\" alt=\"ramon2_web\" width=\"350\" height=\"234\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon2_web.jpg 350w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon2_web-300x201.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon2_web-194x130.jpg 194w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon2_web-150x100.jpg 150w\" data-sizes=\"(max-width: 350px) 100vw, 350px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/234;\" \/><\/p>\n<h6 class=\"caption\" style=\"float: right; width: 50%; padding: 0px 0px 0px 0px;\">Right: Picture of aligned C2C12 muscle cells within hydrogel as obtained by the dielectrophoresis (DEP) technique using 50 \u00b5m electrode 50 \u00b5m gap device (A). Phase contrast images of the aligned C2C12 muscle cells within hydrogel at different culture times (B and C). Scale bar shows 0.25 cm, 400 \u03bcm, and 50 \u03bcm in A, B, and C, respectively.<\/h6>\n<div style=\"clear: both;\"><\/div>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_26909\" aria-describedby=\"caption-attachment-26909\" style=\"width: 290px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"size-full wp-image-26909 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon3_web.jpg\" alt=\"Myotubes differentiated in a groove-ridge topography GelMA-CNTs composite loaded with 0.3 mg\/mL CNTs. Immunostaining of cell nuclei\/myosin heavy chain showing the highly aligned C2C12 myotubes. Z-lines were also observed for the myotubes indicating high maturation of muscle myofibers. Scale bar show 20 \u00b5m.\" width=\"300\" height=\"295\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon3_web.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon3_web-132x130.jpg 132w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon3_web-150x148.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon3_web-45x45.jpg 45w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/295;\" \/><figcaption id=\"caption-attachment-26909\" class=\"wp-caption-text\">Myotubes differentiated in a groove-ridge topography GelMA-CNTs composite loaded with 0.3 mg\/mL CNTs. Immunostaining of cell nuclei\/myosin heavy chain showing the highly aligned C2C12 myotubes. Z-lines were also observed for the myotubes indicating high maturation of muscle myofibers. Scale bar show 20 \u00b5m.<\/figcaption><\/figure>\n<p><img decoding=\"async\" class=\"alignright size-full wp-image-26915 lazyload\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/294;float: right;\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon4_web.jpg\" alt=\"ramon4_web\" width=\"350\" height=\"294\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon4_web.jpg 350w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon4_web-300x252.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon4_web-155x130.jpg 155w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/12\/ramon4_web-150x126.jpg 150w\" data-sizes=\"(max-width: 350px) 100vw, 350px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/p>\n<div style=\"clear: both;\"><\/div>\n\n<\/div><h2 class=\"tabtitle\">News\/Jobs<\/h2>\n<div class=\"tabcontent\">\n\n<h5><a href=\"https:\/\/ibecbarcelona.eu\/ibec-researchers-erc-project-highlighted-in-madrid-exhibition\/\" target=\"_blank\" rel=\"noopener noreferrer\">IBEC researcher\u2019s ERC project highlighted in Madrid exhibition<\/a><\/h5>\n<h6 style=\"color: #aaa;\">28\/03\/17<\/h6>\n<p>This weekend Javier Ramon\u2019s European Research Council-funded project, DAMOC, was one of eight highlighted in a special exhibition in Madrid to mark the ERC\u2019s tenth anniversary.<\/p>\n<hr \/>\n<h5><a href=\"https:\/\/ibecbarcelona.eu\/erc-funding-for-new-diabetes-approach-at-ibec\/\">ERC funding for new diabetes approach at IBEC<\/a><\/h5>\n<h6 style=\"color: #aaa;\">04\/10\/16<\/h6>\n<p>IBEC\u2019s Dr. Javier Ram\u00f3n is one of just six researchers in Catalonia to have been awarded a 2016 Starting Grant by the European Research Council (ERC).<\/p>\n<hr \/>\n\n<\/div><h2 class=\"tabtitle\">Projects<\/h2>\n<div class=\"tabcontent\">\n\n<h5>EU-funded projects<\/h5>\n<table style=\"width: 765px;\">\n<tbody>\n<tr>\n<td><strong>\u2018Diabetes Approach by Multi-Organ-on-a-Chip\u2019 (DAMOC)<\/strong><\/td>\n<td>ERC<\/td>\n<td>Javier Ram\u00f3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\n<\/div><h2 class=\"tabtitle\">Publications<\/h2>\n<div class=\"tabcontent\">\n<br \/>\n<div class=\"loadpubs\"><\/div><script>\n    var url=\"https:\/\/ibecbarcelona.eu\/wp-content\/plugins\/ibec\/pubs\/biosensors-for-bioengineering-3.html\";\n    jQuery(document).ready(function(){\n            jQuery(\".loadpubs\").load(url);\n    });\n    <\/script><br \/>\n(See full publication list in ORCID)<br \/>\n[br]<br \/>\n\n<\/div><h2 class=\"tabtitle\">Equipment<\/h2>\n<div class=\"tabcontent\">\n<br \/>\nMicro and nanofabrication techniques:<\/p>\n<ul>\n<li>3D microstructures on hydrogel materials<\/li>\n<li>Mini-bioreactor for 3D cell culture<\/li>\n<li>Microelectrodes fabrication<\/li>\n<li>Synthesis and chemical modification of polymers and surfaces<\/li>\n<li>Dielectrophoretic cells and micro particles manipulation<\/li>\n<\/ul>\n<p>Characterization techniques:<\/p>\n<ul>\n<li>Optical Microscopes (white light\/epifluorescence)<\/li>\n<li>Electrochemical techniques (Potentiometric\/Amperometric\/Impedance spectroscopy)<\/li>\n<li>Immunosensing techniques (Fluorescence ELISA\/Colorimetric ELISA\/magneto ELISA)<\/li>\n<\/ul>\n<p>Equipment:<\/p>\n<ul>\n<li>Microfluidic systems (High precision syringe pumps\/Peristaltic pumps\/Micro valves)<\/li>\n<li>Biological safety cabinet (class II)<\/li>\n<li>Epifluorescence microscope for live-cell imaging<\/li>\n<\/ul>\n<p>Access to the Nanotechnology Platform (IBEC Core Facilities): equipment for hot embossing lithography, polymer processing and photolithography, chemical wet etching, e-beam evaporation and surface characterization (TOF-SIMS)<br \/>\nAccess to the Scientific and Technological Centers (University of Barcelona): equipment for surface analysis (XPS, AFM, XRD), organic structures characterization (NMR) and microscopy techniques (SEM, TEM, confocal)<\/p>\n\n<\/div><h2 class=\"tabtitle\">Collaborations<\/h2>\n<div class=\"tabcontent\">\n\n<ul>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/nanobioengineering\">Prof. Josep Samitier<\/a><br \/>\n<em>IBEC<\/em><\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/biomsyscelleng\">Dr. Elena Martinez<\/a><br \/>\n<em>IBEC<\/em><\/li>\n<li>Dr. Anna Novials<br \/>\n<em>Institut D\u00b4Investigacions Biomediques August Pi i Sunyer (IDIBAPS)<\/em><\/li>\n<li>Dr. Ramon Gom\u00eds<br \/>\n<em>Institut D\u00b4Investigacions Biomediques August Pi i Sunyer (IDIBAPS)<\/em><\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The Biosensors for bioengineering group is a junior group under IBEC&#8217;s Tenure Track scheme. Drug discovery pathway relies heavily on in vivo animal models and in vitro cell mediums. In &#8230; <a title=\"Biosensors for bioengineering\" class=\"read-more\" href=\"https:\/\/ibecbarcelona.eu\/es\/research-groups\/biosensors-for-bioengineering-3\/\" aria-label=\"More on Biosensors for bioengineering\">Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":12216,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-29689","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biosensors for bioengineering - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/research-groups\/biosensors-for-bioengineering-3\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biosensors for bioengineering - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"The Biosensors for bioengineering group is a junior group under IBEC&#8217;s Tenure Track scheme. 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